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Print ISSN: 0022-1767 Online ISSN: 1550-6606. All rights reserved.1451 Rockville Pike, Suite 650, Rockville, MD 20852The American Association of Immunologists, Inc.,

is published twice each month byThe Journal of Immunology

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VOL. 189 | NO. 3 | August 1, 2012 | Pages 1097–1530

IN THIS ISSUE1097

LETTERS TO THE EDITOR1099 Comment on “Translational Applications of Flow Cytometry in Clinical Practice”

Guillaume Monneret and Fabienne Venet

1099 Comment on “Identification of a New Pathway for Th1 Cell Development Induced by CooperativeStimulation with IL-4 and TGF-b”Nasr Y. A. Hemdan and Gunnar Wichmann

PILLARS OF IMMUNOLOGY1101 Costs and Benefits of Immunity to Worm Infection

Judith A. Appleton

1104 Pillars Article: Downregulation of Th1 Cytokine Production Accompanies Induction of Th2 Responsesby a Parasitic Helminth, Schistosoma mansoni. J. Exp. Med. 1991. 173: 159–166Edward J. Pearce, Patricia Caspar, Jean-Marie Grzych, Fred A. Lewis, and Alan Sher

CUTTING EDGE1113 Cutting Edge: In the Absence of TGF-b Signaling in T Cells, Fewer CD103+ Regulatory T Cells

Develop, but Exuberant IFN-g Production Renders Mice More Susceptible to Helminth InfectionLisa A. Reynolds and Rick M. Maizels

1118 Cutting Edge: Cell-Extrinsic Immune Regulation by CTLA-4 Expressed on Conventional T CellsChun Jing Wang, Rupert Kenefeck, Lukasz Wardzinski, Kesley Attridge, Claire Manzotti, Emily M. Schmidt,

Omar S. Qureshi, David M. Sansom, and Lucy S. K. Walker

1123 Cutting Edge: CTLA-4 on Effector T Cells Inhibits In TransEmily Corse and James P. Allison

On the cover: Th17 cells generated by activation of naive CD4 cells with the target Ag presented by APC induce severeinflammation in a recipient mouse eye expressing the Ag. Shi, G., J. D. Lovaas, C. Tan, B. P. Vistica, E. F. Wawrousek,

M. H. Aziz, R. C. Rigden, R. R. Caspi, and I. Gery. 2012. Cell–cell interaction with APC, not IL-23, is required for naiveCD4 cells to acquire pathogenicity during Th17 lineage commitment. J. Immunol. 189: 1220–1227.

The Journal of Immunology (ISSN 0022-1767) is published twice each month by The American Association of Immunologists,Inc., 9650 Rockville Pike, Bethesda, MD 20814-3994, Phone: 301-634-7197, Fax: 301-634-7829. Subscription terms: Newsubscriptions and renewals begin January 1 and expire one year later (see http://www.jimmunol.org/subscriptions for prices and

details). A special rate is available to members of The American Association of Immunologists, Inc. (see http://www.aai.org/membership). The American Association of Immunologists, Inc., is not responsible for undeliverable issues. Replacement issuescan be obtained, if available, at the regular price of single issues (see http://www.jimmunol.org/pdf/single_issue_purchase.pdf).

Reprints of individual articles are available only from authors. Periodicals postage paid at Bethesda, MD 20814-3994, and atadditional mailing offices. Country of origin U.S.A. Printed on acid-free recyclable paper. Postmaster: Send address changes60 days in advance to The Journal of Immunology, Subscription Department, 9650 Rockville Pike, Bethesda, MD 20814-3994.Copyright � 2012 by The American Association of Immunologists, Inc.

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1128 Cutting Edge: Clec9A+ Dendritic Cells Mediate the Development of Experimental Cerebral MalariaLucia Piva, Piotr Tetlak, Carla Claser, Klaus Karjalainen, Laurent Renia, and Christiane Ruedl

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION1133 Cathepsin B Controls the Persistence of Memory CD8+ T Lymphocytes

Susan M. Byrne, Anne Aucher, Syarifah Alyahya, Matthew Elder, Steven T. Olson, Daniel M. Davis,

and Philip G. Ashton-Rickardt

1144 Human Bocavirus NP1 Inhibits IFN-b Production by Blocking Association of IFN Regulatory Factor 3with IFNB PromoterZhenfeng Zhang, Zhenhua Zheng, Huanle Luo, Jin Meng, Hongxia Li, Qian Li, Xiaowei Zhang, Xianliang Ke, Bingke Bai,

Panyong Mao, Qinxue Hu, and Hanzhong Wang

1154 Interchangeability of Themis1 and Themis2 in Thymocyte Development Reveals Two Related Proteins withConserved Molecular FunctionRenaud Lesourne, Ekaterina Zvezdova, Ki-Duk Song, Dalal El-Khoury, Shoji Uehara, Valarie A. Barr,

Lawrence E. Samelson, and Paul E. Love

1162 Targeting Stat3 Induces Senescence in Tumor Cells and Elicits Prophylactic and Therapeutic ImmuneResponses against Breast Cancer Growth Mediated by NK Cells and CD4+ T CellsMercedes Tkach, Lorena Coria, Cinthia Rosemblit, Martin A. Rivas, Cecilia J. Proietti, Maria Celeste Diaz Flaqu�e,Wendy Beguelin, Isabel Frahm, Eduardo H. Charreau, Juliana Cassataro, Patricia V. Elizalde, and Roxana Schillaci

1173 The IL-2 Diphtheria Toxin Fusion Protein Denileukin Diftitox Modulates the Onset of Diabetes in FemaleNonobese Diabetic Animals in a Time-Dependent Manner and Breaks Tolerance in Male NonobeseDiabetic AnimalsElisabeth Zinser, Susanne Rossner, Leonie Littmann, Nadine Pangratz, Gerold Schuler, and Alexander Steinkasserer

1182 Mesenchymal Stem/Stromal Cells Induce the Generation of Novel IL-10–Dependent Regulatory DendriticCells by SOCS3 ActivationXingxia Liu, Xuebin Qu, Yuan Chen, Lianming Liao, Kai Cheng, Changshun Shao, Martin Zenke, Armand Keating,

and Robert C. H. Zhao

1193 Transgenic Overexpression of G5PR That Is Normally Augmented in Centrocytes Impairs the Enrichmentof High-Affinity Antigen-Specific B Cells, Increases Peritoneal B-1a Cells, and Induces Autoimmunity inAged Female MiceMasahiro Kitabatake, Teppei Toda, Kazuhiko Kuwahara, Hideya Igarashi, Mareki Ohtsuji, Hiromichi Tsurui,

Sachiko Hirose, and Nobuo Sakaguchi

1202 B7–CD28 Costimulatory Signals Control the Survival and Proliferation of Murine and Human gd T Cellsvia IL-2 ProductionJulie C. Ribot, Ana deBarros, Liliana Mancio-Silva, Ana Pamplona, and Bruno Silva-Santos

1209 Chronic Activation of the Kinase IKKb Impairs T Cell Function and SurvivalSruti Krishna, Danli Xie, Balachandra Gorentla, Jinwook Shin, Jimin Gao, and Xiao-Ping Zhong

1220 Cell–Cell Interaction with APC, not IL-23, Is Required for Naive CD4 Cells To Acquire Pathogenicityduring Th17 Lineage CommitmentGuangpu Shi, Jenna D. Lovaas, Cuiyan Tan, Barbara P. Vistica, Eric F. Wawrousek, Mehak K. Aziz, Rachael C. Rigden,

Rachel R. Caspi, and Igal Gery

1228 Programming of Regulatory T Cells from Pluripotent Stem Cells and Prevention of AutoimmunityRizwanul Haque, Fengyang Lei, Xiaofang Xiong, Yanqing Bian, Baohua Zhao, Yuzhang Wu, and Jianxun Song

1237 Retinal Laser Burn-Induced Neuropathy Leads to Substance P-Dependent Loss of Ocular Immune PrivilegeKenyatta Lucas, Dimitris Karamichos, Rose Mathew, James D. Zieske, and Joan Stein-Streilein

1243 A Protective Role for Human IL-10–Expressing CD4+ T Cells in ColitisDilini C. Ranatunga, Amritha Ramakrishnan, Priyanka Uprety, Fengying Wang, Hao Zhang, Joseph B. Margolick,

Cory Brayton, and Jay H. Bream

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1253 Transcription Factor Zinc Finger and BTB Domain 1 Is Essential for Lymphocyte DevelopmentDivya Punwani, Karen Simon, Youngnim Choi, Amalia Dutra, Diana Gonzalez-Espinosa, Evgenia Pak,

Martin Naradikian, Chang-Hwa Song, Jenny Zhang, David M. Bodine, and Jennifer M. Puck

1265 The Adjuvant LT-K63 Can Restore Delayed Maturation of Follicular Dendritic Cells and PoorPersistence of Both Protein- and Polysaccharide-Specific Antibody-Secreting Cells in Neonatal MiceStefania P. Bjarnarson, Brenda C. Adarna, Hreinn Benonisson, Giuseppe Del Giudice, and Ingileif Jonsdottir

1274 Noncanonical Notch Signaling Modulates Cytokine Responses of Dendritic Cells to Inflammatory StimuliMadeleine E. Gentle, Anna Rose, Laurence Bugeon, and Margaret J. Dallman

1285 Multieffector-Functional Immune Responses of HMBPP-Specific Vg2Vd2 T Cells in NonhumanPrimates Inoculated with Listeria monocytogenes DactA prfA*Bridgett Ryan-Payseur, James Frencher, Ling Shen, Crystal Y. Chen, Dan Huang, and Zheng W. Chen

1294 A Regulatory Role for IL-10 Receptor Signaling in Development and B Cell Help of T FollicularHelper Cells in MiceGang Cai, Xiaomeng Nie, Weiwei Zhang, Beiying Wu, Jiafei Lin, Huaizhou Wang, Cen Jiang, and Qian Shen

1303 Extracellular ATP Exerts Opposite Effects on Activated and Regulatory CD4+ T Cells via Purinergic P2Receptor ActivationSara Trabanelli, Darina O�cadlikov�a, Sara Gulinelli, Antonio Curti, Valentina Salvestrini, Rodolfo de Paula Vieira,

Marco Idzko, Francesco Di Virgilio, Davide Ferrari, and Roberto M. Lemoli

1311 Diet-Induced Obesity Alters Dendritic Cell Function in the Presence and Absence of Tumor GrowthBritnie R. James, Ann Tomanek-Chalkley, Eric J. Askeland, Tamara Kucaba, Thomas S. Griffith, and Lyse A. Norian

1322 m-Chain–Deficient Mice Possess B-1 Cells and Produce IgG and IgE, but Not IgA, following SystemicSensitization and Inhalational Challenge in a Fungal Asthma ModelSumit Ghosh, Scott A. Hoselton, and Jane M. Schuh

1330 Substrate Rigidity Regulates Human T Cell Activation and ProliferationRoddy S. O’Connor, Xueli Hao, Keyue Shen, Keenan Bashour, Tatiana Akimova, Wayne W. Hancock, Lance C. Kam,

and Michael C. Milone

1340 Chronic Alcohol Consumption Impairs Distribution and Compromises Circulation of B Cells in B16BL6Melanoma-Bearing MiceHui Zhang, Zhaohui Zhu, and Gary G. Meadows

1349 Vaccines Expressing the Innate Immune Modulator EAT-2 Elicit Potent Effector Memory T LymphocyteResponses despite Pre-Existing Vaccine ImmunityYasser Ali Aldhamen, Sergey S. Seregin, Nathaniel J. Schuldt, David P. W. Rastall, Chyong-jy J. Liu, Sarah Godbehere,

and Andrea Amalfitano

1360 Comprehensive Analysis of NKG2D Ligand Expression and Release in Leukemia: Implications forNKG2D-Mediated NK Cell ResponsesJulia Hilpert, Ludger Grosse-Hovest, Frank Grunebach, Corina Buechele, Tina Nuebling, Tobias Raum, Alexander Steinle,

and Helmut Rainer Salih

MOLECULAR AND STRUCTURAL IMMUNOLOGY1372 Redundant and Nonredundant Functions of ATM and H2AX in ab T-Lineage Lymphocytes

Bu Yin, Baeck-Seung Lee, Katherine S. Yang-Iott, Barry P. Sleckman, and Craig H. Bassing

1380 Epigenetic Silencing of Cd8 Genes by ThPOK-Mediated Deacetylation during CD4 T Cell DifferentiationJinxiu Rui, Haifeng Liu, Xiaoyan Zhu, Yu Cui, and Xiaolong Liu

1391 The Peptide-Receptive Transition State of MHC Class I Molecules: Insight from Structure and MolecularDynamicsMichael G. Mage, Michael A. Dolan, Rui Wang, Lisa F. Boyd, Maria Jamela Revilleza, Howard Robinson,

Kannan Natarajan, Nancy B. Myers, Ted H. Hansen, and David H. Margulies

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1400 Transcriptional Regulator Id2 Is Required for the CD4 T Cell Immune Response in the Development ofExperimental Autoimmune EncephalomyelitisYen-Yu Lin, Mary E. Jones-Mason, Makoto Inoue, Anna Lasorella, Antonio Iavarone, Qi-Jing Li, Mari L. Shinohara,

and Yuan Zhuang

IMMUNOGENETICS1406 Subcongenic Analyses Reveal Complex Interactions between Distal Chromosome 4 Genes Controlling

Diabetogenic B Cells and CD4 T Cells in Nonobese Diabetic MiceJessica Stolp, Yi-Guang Chen, Selwyn L. Cox, Vivien Henck, Wenyu Zhang, Shirng-Wern Tsaih, Harold Chapman,

Timothy Stearns, David V. Serreze, and Pablo A. Silveira

1418 Mutation at Positively Selected Positions in the Binding Site for HLA-C Shows That KIR2DL1 Is a MoreRefined but Less Adaptable NK Cell Receptor Than KIR2DL3Hugo G. Hilton, Luca Vago, Anastazia M. Older Aguilar, Achim K. Moesta, Thorsten Graef, Laurent Abi-Rached,

Paul J. Norman, Lisbeth A. Guethlein, Katharina Fleischhauer, and Peter Parham

HOST DEFENSE1431 Species Selectivity in Poxviral Complement Regulators Is Dictated by the Charge Reversal in the Central

Complement Control Protein ModulesViveka Nand Yadav, Kalyani Pyaram, Muzammil Ahmad, and Arvind Sahu

1440 Antigen-Driven Induction of Polyreactive IgM during Intracellular Bacterial InfectionDerek D. Jones, Gregory A. DeIulio, and Gary M. Winslow

1448 Extracellularly Delivered Single-Stranded Viral RNA Causes Neurodegeneration Dependent on TLR7Sabrina M. Lehmann, Karen Rosenberger, Christina Kruger, Piet Habbel, Katja Derkow, David Kaul, Agnieszka Rybak,

Christine Brandt, Eckart Schott, F. Gregory Wulczyn, and Seija Lehnardt

1459 Helminth Infection Impairs Autophagy-Mediated Killing of Bacterial Enteropathogens by MacrophagesChien-wen Su, Yue Cao, Mei Zhang, Jess Kaplan, Libo Su, Ying Fu, W. Allan Walker, Ramnik Xavier, Bobby J. Cherayil,

and Hai Ning Shi

1467 Vaccination with Cancer- and HIV Infection-Associated Endogenous Retrotransposable Elements Is Safeand ImmunogenicJonah B. Sacha, In-Jeong Kim, Lianchun Chen, Jakir H. Ullah, David A. Goodwin, Heather A. Simmons,

Daniel I. Schenkman, Frederike von Pelchrzim, Robert J. Gifford, Francesca A. Nimityongskul, Laura P. Newman,

Samantha Wildeboer, Patrick B. Lappin, Daisy Hammond, Philip Castrovinci, Shari M. Piaskowski, Jason S. Reed,

Kerry A. Beheler, Tharsika Tharmanathan, Ningli Zhang, Sophie Muscat-King, Melanie Rieger, Carla Fernandes,

Klaus Rumpel, Joseph P. Gardner, II, Douglas H. Gebhard, Juliann Janies, Ahmed Shoieb, Brian G. Pierce, Dusko Trajkovic,

Eva Rakasz, Sing Rong, Michael McCluskie, Clare Christy, James R. Merson, R. Brad Jones, Douglas F. Nixon,

Mario A. Ostrowski, Peter T. Loudon, Ingrid M. Pruimboom-Brees, and Neil C. Sheppard

INFLAMMATION1480 Critical Role for CCAAT/Enhancer-Binding Protein b in Immune Complex-Induced Acute Lung Injury

Chunguang Yan, Min Wu, Jay Cao, Huifang Tang, Mei Zhu, Peter F. Johnson, and Hongwei Gao

1491 Virologically Suppressed HIV Patients Show Activation of NK Cells and Persistent Innate ImmuneActivationGregor F. Lichtfuss, Wan-Jung Cheng, Yagmur Farsakoglu, Geza Paukovics, Reena Rajasuriar, Pushparaj Velayudham,

Marit Kramski, Anna C. Hearps, Paul U. Cameron, Sharon R. Lewin, Suzanne M. Crowe, and Anthony Jaworowski

1500 IFN-b Expression Is Directly Activated in Human Neutrophils Transfected with Plasmid DNA and IsFurther Increased via TLR-4–Mediated SignalingNicola Tamassia, Flavia Bazzoni, Vincent Le Moigne, Federica Calzetti, Caterina Masala, Giulia Grisendi, Uta Bussmeyer,

Sara Scutera, Marzia De Gironcoli, Claudio Costantini, Tiziana Musso, and Marco A. Cassatella

1510 Endoplasmic Reticulum Stress Response Promotes Cytotoxic Phenotype of CD8ab+ IntraepithelialLymphocytes in a Mouse Model for Crohn’s Disease-like IleitisJung-Su Chang, Soeren Ocvirk, Emanuel Berger, Sigrid Kisling, Uli Binder, Arne Skerra, Amy S. Lee, and Dirk Haller

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CLINICAL IMMUNOLOGY1521 Chronic Mucocutaneous Candidiasis Caused by a Gain-of-Function Mutation in the STAT1 DNA-Binding

DomainShunichiro Takezaki, Masafumi Yamada, Masahiko Kato, Myoung-ja Park, Kenichi Maruyama, Yasuhiro Yamazaki,

Natsuko Chida, Osamu Ohara, Ichiro Kobayashi, and Tadashi Ariga

CORRECTIONS1527 Correction: June 15, 2012, In This Issue

1528 AUTHOR INDEX

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