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is published twice each month byThe Journal of Immunology

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VOL. 184 | NO. 7 | April 1, 2010 | Pages 3301–4048

IN THIS ISSUE3301

PILLARS OF IMMUNOLOGY3303 An Alternative Path for Antigen Presentation: Group 1 CD1 Proteins

Jack L. Strominger

3306 Pillars Article: Recognition of Cluster of Differentiation 1 Antigens by Human CD4−CD8− CytolyticT Lymphocyte. Nature. 1989. 341: 447–450Steven Porcelli, Michael B. Brenner, Julia L. Greenstein, Cox Terhorst, Steven P. Balk, and Paul A. Bleicher

BRIEF REVIEWS3311 Translation Control: A Multifaceted Regulator of Inflammatory Response

Barsanjit Mazumder, Xiaoxia Li, and Sailen Barik

CUTTING EDGE3321 Cutting Edge: Novel Function of B Cell-Activating Factor in the Induction of IL-10–Producing

Regulatory B CellsMin Yang, Lingyun Sun, Shengjun Wang, King-Hung Ko, Huaxi Xu, Bo-Jian Zheng, Xuetao Cao, and Liwei Lu

3326 Cutting Edge: Caspase-1 Independent IL-1b Production Is Critical for Host Resistance to Mycobacteriumtuberculosis and Does Not Require TLR Signaling In VivoKatrin D. Mayer-Barber, Daniel L. Barber, Kevin Shenderov, Sandra D. White, Mark S. Wilson, Allen Cheever,

David Kugler, Sara Hieny, Patricia Caspar, Gabriel N�u~nez, Dirk Schlueter, Richard A. Flavell, Fayyaz S. Sutterwala,

and Alan Sher

3331 Cutting Edge: A Critical Role for the G Protein-Coupled Receptor mFPR2 in Airway Inflammation andImmune ResponsesKeqiang Chen, Yingying Le, Ying Liu, Wanghua Gong, Guoguang Ying, Jian Huang, Teizo Yoshimura, Lino Tessarollo,

and Ji Ming Wang

On the cover: The illustration shows a mouse colon rolled up, sectioned, and stained with anti-IgM (red) and anti-IgA (green)Abs. Isolated lymphoid follicles and colonic patches appear as red areas, and IgA-producing plasma cells in the lamina propriaare stained green. Bergqvist, P., A. Stensson, N. Y. Lycke, and M. Bemark. 2010. T cell-independent IgA class switchrecombination is restricted to the GALT and occurs prior to manifest germinal center formation. J. Immunol. 184:3545–3553.

The Journal of Immunology (ISSN 0022-1767) is published twice each month by The American Association of Immunologists,

Inc., 9650 Rockville Pike, Bethesda, MD 20814-3994, Phone: 301-634-7197, Fax: 301-634-7829. Subscription terms: Newsubscriptions and renewals begin January 1 and expire one year later (see http://www.jimmunol.org/subscriptions for prices anddetails). A special rate is available to members of The American Association of Immunologists, Inc. (see http://www.aai.org/

membership). The American Association of Immunologists, Inc., is not responsible for undeliverable issues. Replacement issuescan be obtained, if available, at the regular price of single issues (see http://www.jimmunol.org/pdf/single_issue_purchase.pdf).Reprints of individual articles are available only from authors. Periodicals postage paid at Bethesda, MD 20814-3994, and atadditional mailing offices. Country of origin U.S.A. Printed on acid-free recyclable paper. Postmaster: Send address changes

60 days in advance to The Journal of Immunology, Subscription Department, 9650 Rockville Pike, Bethesda, MD 20814-3994.Copyright � 2010 by The American Association of Immunologists, Inc.

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3336 Cutting Edge: Mast Cells Express IL-17A in Rheumatoid Arthritis SynoviumAxel J. Hueber, Darren L. Asquith, Ashley M. Miller, Jim Reilly, Shauna Kerr, Jan Leipe, Alirio J. Melendez,

and Iain B. McInnes

3341 Cutting Edge: Critical Role of IkB Kinase a in TLR7/9-Induced Type I IFN Production by ConventionalDendritic CellsKatsuaki Hoshino, Izumi Sasaki, Takahiro Sugiyama, Takahiro Yano, Chihiro Yamazaki, Teruhito Yasui,

Hitoshi Kikutani, and Tsuneyasu Kaisho

3346 Cutting Edge: The Membrane Type Matrix Metalloproteinase MMP14 Mediates Constitutive Shedding ofMHC Class I Chain-Related Molecule A Independent of A Disintegrin and MetalloproteinasesGang Liu, Catherine L. Atteridge, Xuanjun Wang, Ashley D. Lundgren, and Jennifer D. Wu

3351 Cutting Edge: H-2Ld Class I Molecule Protects an HIV N-Extended Epitope from In Vitro Trimming byEndoplasmic Reticulum Aminopeptidase Associated with Antigen ProcessingSusana Infantes, Yolanda Samino, Elena Lorente, Mercedes Jim�enez, Ruth Garcia, Margarita Del Val, and Daniel L�opez

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION3357 MHC Class I Molecules with Superenhanced CD8 Binding Properties Bypass the Requirement for Cognate

TCR Recognition and Nonspecifically Activate CTLsLinda Wooldridge, Mathew Clement, Anna Lissina, Emily S. J. Edwards, Kristin Ladell, Julia Ekeruche, Rachel E. Hewitt,

Bruno Laugel, Emma Gostick, David K. Cole, Reno Debets, Cor Berrevoets, John J. Miles, Scott R. Burrows, David A. Price,

and Andrew K. Sewell

3367 CpG-B Oligodeoxynucleotides Inhibit TLR-Dependent and -Independent Induction of Type I IFN inDendritic CellsYi C. Liu, Reginald C. Gray, Gareth A. D. Hardy, John Kuchtey, Derek W. Abbott, Steven N. Emancipator,

and Clifford V. Harding

3377 FoxP3+RORgt+ T Helper Intermediates Display Suppressive Function against Autoimmune DiabetesDanielle M. Tartar, Amie M. VanMorlan, Xiaoxiao Wan, F. Betul Guloglu, Renu Jain, Cara L. Haymaker, Jason S. Ellis,

Christine M. Hoeman, Jason A. Cascio, Mermagya Dhakal, Mohamed Oukka, and Habib Zaghouani

3386 Secreted IgM Enhances B Cell Receptor Signaling and Promotes Splenic but Impairs Peritoneal B CellSurvivalClare A. Notley, Nicole Baker, and Michael R. Ehrenstein

3394 Activation of Tolerogenic Dendritic Cells in the Tumor Draining Lymph Nodes by CD8+ T CellsEngineered to Express CD40 LigandEileen M. Higham, K. Dane Wittrup, and Jianzhu Chen

3401 CD47 Is Required for Suppression of Allograft Rejection by Donor-Specific TransfusionHui Wang, Xiaojian Wu, Yuantao Wang, Per-Arne Oldenborg, and Yong-Guang Yang

3408 ATP Activates Regulatory T Cells In Vivo during Contact Hypersensitivity ReactionsSabine Ring, Alexander H. Enk, and Karsten Mahnke

3417 Cytomegalovirus Infection Reduces Telomere Length of the Circulating T Cell PoolPablo J. E. J. van de Berg, Stephen J. Griffiths, Si-La Yong, Richard Macaulay, Frederike J. Bemelman, Sarah Jackson,

Sian M. Henson, Ineke J. M. ten Berge, Arne N. Akbar, and Ren�e A. W. van Lier

3424 Effects of MHC Class I Alleles on Licensing of Ly49A+ NK CellsA. Helena Jonsson, Liping Yang, Sungjin Kim, Samantha M. Taffner, and Wayne M. Yokoyama

3433 Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived fromPeripherally Induced Foxp3+ T Regulatory CellsAngela M. Thornton, Patricia E. Korty, Dat Q. Tran, Elizabeth A. Wohlfert, Patrick E. Murray, Yasmine Belkaid,

and Ethan M. Shevach

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3442 Blockade of Programmed Death Ligand 1 Enhances the Therapeutic Efficacy of CombinationImmunotherapy against MelanomaShari Pilon-Thomas, Amy Mackay, Nasreen Vohra, and James J. Mul�e

3450 CXC Chemokine Ligand (CXCL) 9 and CXCL10 Are Antagonistic Costimulation Molecules during thePriming of Alloreactive T Cell EffectorsJoshua M. Rosenblum, Naohiko Shimoda, Austin D. Schenk, Howard Zhang, Danielle D. Kish, Karen Keslar,

Joshua M. Farber, and Robert L. Fairchild

3461 IL-7 Is Essential for Homeostatic Control of T Cell Metabolism In VivoSarah R. Jacobs, Ryan D. Michalek, and Jeffrey C. Rathmell

3470 Increased Foxp3+ Regulatory T Cells in Poly(ADP-Ribose) Polymerase-1 DeficiencyFrancesca Nasta, Federica Laudisi, Manolo Sambucci, Maria M. Rosado, and Claudio Pioli

3478 IFN-b Inhibits Dendritic Cell Migration through STAT-1–Mediated Transcriptional Suppression ofCCR7 and Matrix Metalloproteinase 9Jui-Hung Yen, Weimin Kong, and Doina Ganea

3487 Melatonin Protects CD4+ T Cells from Activation-Induced Cell Death by Blocking NFAT-MediatedCD95 Ligand UpregulationAlziana Moreno da Cunha Pedrosa, Ricardo Weinlich, Giuliana Patricia Mognol, Bruno Kaufmann Robbs,

Joao Paulo de Biaso Viola, Ana Campa, and Gustavo Pessini Amarante-Mendes

3495 PE_PGRS Antigens of Mycobacterium tuberculosis Induce Maturation and Activation of Human DendriticCellsKushagra Bansal, Sri Ramulu Elluru, Yeddula Narayana, Rashmi Chaturvedi, Shripad A. Patil, Srini V. Kaveri,

Jagadeesh Bayry, and Kithiganahalli N. Balaji

3505 Bacterial Teichoic Acids Reverse Predominant IL-12 Production Induced by Certain Lactobacillus Strainsinto Predominant IL-10 Production via TLR2-Dependent ERK Activation in MacrophagesRumi Kaji, Junko Kiyoshima-Shibata, Masato Nagaoka, Masanobu Nanno, and Kan Shida

3514 BTN1A1, the Mammary Gland Butyrophilin, and BTN2A2 Are Both Inhibitors of T Cell ActivationIsobel A. Smith, Brittany R. Knezevic, Johannes U. Ammann, David A. Rhodes, Danielle Aw, Donald B. Palmer,

Ian H. Mather, and John Trowsdale

3526 Antimicrobial Peptides Human b-Defensins and Cathelicidin LL-37 Induce the Secretion of a PruritogenicCytokine IL-31 by Human Mast CellsFrancois Niyonsaba, Hiroko Ushio, Mutsuko Hara, Hidenori Yokoi, Mitsutoshi Tominaga, Kenji Takamori,

Naoki Kajiwara, Hirohisa Saito, Isao Nagaoka, Hideoki Ogawa, and Ko Okumura

3535 TLR4 Signaling in Stromal Cells Is Critical for the Initiation of Allergic Th2 Responses to Inhaled AntigenAnna M. Tan, Hui-Chen Chen, Pierre Pochard, Stephanie C. Eisenbarth, Christina A. Herrick, and H. Kim Bottomly

3545 T Cell-Independent IgA Class Switch Recombination Is Restricted to the GALT and Occurs Prior toManifest Germinal Center FormationPeter Bergqvist, Anneli Stensson, Nils Y. Lycke, and Mats Bemark

3554 Depleting Syndecan-4+ T Lymphocytes Using Toxin-Bearing Dendritic Cell-Associated Heparan SulfateProteoglycan-Dependent Integrin Ligand: A New Opportunity for Treating Activated T Cell-DrivenDiseaseHideo Akiyoshi, Jin-Sung Chung, Mizuki Tomihari, Ponciano D. Cruz, Jr., and Kiyoshi Ariizumi

3562 The IL-7 Signaling Pathway Regulates Lymph Node Development Independent of Peripheral LymphocytesSt�ephane Chappaz and Daniela Finke

3570 TNF Activates a NF-kB–Regulated Cellular Program in Human CD45RA– Regulatory T Cells thatModulates Their Suppressive FunctionMeital Nagar, Jasmine Jacob-Hirsch, Helly Vernitsky, Yackov Berkun, Shomron Ben-Horin, Ninette Amariglio, Ilan Bank,

Yoel Kloog, Gideon Rechavi, and Itamar Goldstein

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3582 SHIP1 Inhibition Increases Immunoregulatory Capacity and Triggers Apoptosis of Hematopoietic CancerCellsRobert Brooks, Gwenny M. Fuhler, Sonia Iyer, Michelle J. Smith, Mi-Young Park, Kim H. T. Paraiso, Robert W. Engelman,

and William G. Kerr

3590 Hemokinin-1 Activates the MAPK Pathway and Enhances B Cell Proliferation and Antibody ProductionWei Wang, Qian Li, Jun Zhang, Hounan Wu, Yanhui Yin, Qing Ge, and Yu Zhang

3598 Anergic CD4+ T Cells Form Mature Immunological Synapses with Enhanced Accumulation of c-Cbl andCbl-bMelissa Doherty, Douglas G. Osborne, Diana L. Browning, David C. Parker, and Scott A. Wetzel

3609 A Protease-Dependent Mechanism for Initiating T-Dependent B Cell Responses to Large ParticulateAntigensDrew M. Catron, Kathryn A. Pape, Brian T. Fife, Nico van Rooijen, and Marc K. Jenkins

3618 CD22 3 Siglec-G Double-Deficient Mice Have Massively Increased B1 Cell Numbers and DevelopSystemic AutoimmunityJulia Jellusova, Ute Wellmann, Kerstin Amann, Thomas H. Winkler, and Lars Nitschke

3628 The Actin-Bundling Protein L-Plastin Dissociates CCR7 Proximal Signaling from CCR7-Induced MotilitySharon Celeste Morley, Chen Wang, Wan-Lin Lo, Chan-Wang J. Lio, Bernd H. Zinselmeyer, Mark J. Miller, Eric J. Brown,

and Paul M. Allen

3639 Expression of the Autoimmune Susceptibility Gene FcRL3 on Human Regulatory T Cells Is Associated withDysfunction and High Levels of Programmed Cell Death-1Louise A. Swainson, Jeff E. Mold, Urmila D. Bajpai, and Joseph M. McCune

3648 GP41-Specific Antibody Blocks Cell-Free HIV Type 1 Transcytosis through Human Rectal Mucosa andModel Colonic EpitheliumRuizhong Shen, Ernesto R. Drelichman, Diane Bimczok, Christina Ochsenbauer, John C. Kappes, Jamie A. Cannon,

Daniela Tudor, Morgane Bomsel, Lesley E. Smythies, and Phillip D. Smith

MOLECULAR AND STRUCTURAL IMMUNOLOGY3656 Impaired Lymphoid Organ Development in Mice Lacking the Heparan Sulfate Modifying Enzyme

Glucuronyl C5-EpimeraseRogier M. Reijmers, Mark F. R. Vondenhoff, Ramon Roozendaal, Annemieke Kuil, Jin-Ping Li, Marcel Spaargaren,

Steven T. Pals, and Reina E. Mebius

3665 Swiprosin-1/EFhd2 Controls B Cell Receptor Signaling through the Assembly of the B Cell Receptor, Syk,and Phospholipase C g2 in Membrane RaftsCarmen Kroczek, Christiane Lang, Sebastian Brachs, Marcus Grohmann, Sebastian D€utting, Astrid Schweizer,

Lars Nitschke, Stephan M. Feller, Hans-Martin J€ack, and Dirk Mielenz

3677 Activation of Mast Cells by Trimeric G Protein Gi3; Coupling to the A3 Adenosine Receptor Directly andupon T Cell ContactDana Baram, Ornit Dekel, Yoseph A. Mekori, and Ronit Sagi-Eisenberg

3689 A New Type of Membrane Raft-Like Microdomains and Their Possible Involvement in TCR SignalingPavel Ot�ahal, Pavla Angelisov�a, Matou�s Hrdinka, Tom�a�s Brdi�cka, Petr Nov�ak, Karel Drbal, and V�aclav Ho�rej�si

3697 Integrin aMb2 Clustering Triggers Phosphorylation and Activation of Protein Kinase Cd that RegulatesTranscription Factor Foxp1 Expression in MonocytesZhi-Hong Xue, Chang-Qing Zhao, Geok-Lin Chua, Sze-Wah Tan, Xiao-Yan Tang, Siew-Cheng Wong, and Suet-Mien Tan

3710 In Vivo Redundant Function of the 3´ IgH Regulatory Element HS3b in the MouseAnne-Ga€elle B�ebin, Claire Carrion, Marie Marquet, Nadine Cogn�e, Sandrine Lecardeur, Michel Cogn�e, and Eric Pinaud

3718 The Septic Shock-Associated IL-1021082 A > G Polymorphism Mediates Allele-Specific Transcription viaPoly(ADP-Ribose) Polymerase 1 in Macrophages Engulfing Apoptotic CellsXiaoyan Kang, Ha-Jeong Kim, Michelle Ramirez, Sarah Salameh, and Xiaojing Ma

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3725 Antibody-Dependent Cell-Mediated Cytotoxicity- and Complement-Dependent Cytotoxicity-IndependentBactericidal Activity of an IgG against Pseudomonas aeruginosa O6adXuemei Xie, Michael D. McLean, and J. Christopher Hall

IMMUNOGENETICS3734 Antibody Repertoire Development in Fetal and Neonatal Piglets. XI. The Relationship of Variable Heavy

Chain Gene Usage and the Genomic Organization of the Variable Heavy Chain LocusTomoko Eguchi-Ogawa, Nancy Wertz, Xiu-Zhu Sun, Francois Puimi, Hirohide Uenishi, Kevin Wells, Patrick Chardon,

Gregory J. Tobin, and John E. Butler

3743 Loss of T Cell and B Cell Quiescence Precedes the Onset of Microbial Flora-DependentWasting Disease andIntestinal Inflammation in Gimap5-Deficient MiceMichael J. Barnes, Halil Aksoylar, Philippe Krebs, Tristan Bourdeau, Carrie N. Arnold, Yu Xia, Kevin Khovananth,

Isaac Engel, Sosathya Sovath, Kristin Lampe, Eleana Laws, Amy Saunders, Geoffrey W. Butcher, Mitchell Kronenberg,

Kris Steinbrecher, David Hildeman, H. Leighton Grimes, Bruce Beutler, and Kasper Hoebe

HOST DEFENSE3755 Type I IFN Signaling Constrains IL-17A/F Secretion by gd T Cells during Bacterial Infections

Thomas Henry, Girish S. Kirimanjeswara, Thomas Ruby, Jonathan W. Jones, Kaitian Peng, Magali Perret, Lena Ho,

John-Demian Sauer, Yoichiro Iwakura, Dennis W. Metzger, and Denise M. Monack

3768 IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in SepsisJacqueline Unsinger, Margaret McGlynn, Kevin R. Kasten, Andrew S. Hoekzema, Eizo Watanabe, Jared T. Muenzer,

Jacquelyn S. McDonough, Johannes Tschoep, Thomas A. Ferguson, Jonathan E. McDunn, Michel Morre,

David A. Hildeman, Charles C. Caldwell, and Richard S. Hotchkiss

3780 Th1 Cytokine Responses Fail to Effectively Control Chlamydia Lung Infection in ICOS Ligand KnockoutMiceKamran Kadkhoda, Shuhe Wang, Antony George Joyee, Yijun Fan, Jie Yang, and Xi Yang

3789 Carbohydrate Oxidation Acidifies Endosomes, Regulating Antigen Processing and TLR9 SignalingColleen J. Lewis and Brian A. Cobb

3801 Febrile-Range Hyperthermia Augments Lipopolysaccharide-Induced Lung Injury by a Mechanism ofEnhanced Alveolar Epithelial ApoptosisAnne B. Lipke, Gustavo Matute-Bello, Raquel Herrero, Kiyoyasu Kurahashi, Venus A. Wong, Stephen M. Mongovin,

and Thomas R. Martin

3814 Natural Exposure to Cutaneous Anthrax Gives Long-Lasting T Cell Immunity EncompassingInfection-Specific EpitopesRebecca J. Ingram, G€okhan Metan, Bernard Maillere, Mehmet Doganay, Yusuf Ozkul, Louise U. Kim, Les Baillie,

Hugh Dyson, E. Diane Williamson, Karen K. Chu, Stephanie Ascough, Steven Moore, Theresa B. Huwar, John H. Robinson,

Shiranee Sriskandan, and Daniel M. Altmann

3822 Antigenic Variation in Treponema pallidum: TprK Sequence Diversity Accumulates in Response toImmune Pressure during Experimental SyphilisLorenzo Giacani, Barbara J. Molini, Eric Y. Kim, B. Charmie Godornes, B. Troy Leader, Lauren C. Tantalo,

Arturo Centurion-Lara, and Sheila A. Lukehart

3830 IL-32 Is a Host Protective Cytokine against Mycobacterium tuberculosis in Differentiated THP-1 HumanMacrophagesXiyuan Bai, Soo-Hyun Kim, Tania Azam, Mischa T. McGibney, Hua Huang, Charles A. Dinarello, and Edward D. Chan

3841 Identification of a Unique Population of Tissue-Memory CD4+ T Cells in the Airways after InfluenzaInfection That Is Dependent on the Integrin VLA-1Timothy J. Chapman and David J. Topham

3850 Persistent g-Herpesvirus Infection Induces a CD4 T Cell Response Containing Functionally DistinctEffector PopulationsKathleen A. Stuller, Stephanie S. Cush, and Emilio Fla~no

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INFLAMMATION3857 Markers of Monocyte Activation Revealed by Lipidomic Profiling of Arachidonic Acid-Containing

PhospholipidsDavid Balgoma, Alma M. Astudillo, Gema P�erez-Chac�on, Olimpio Montero, Maria A. Balboa, and Jes�us Balsinde

3866 Triptolide Inhibits IL-12/IL-23 Expression in APCs via CCAAT/Enhancer-Binding Protein aYan Zhang and Xiaojing Ma

3878 Hypoxia-Mediated Expression of 5-Lipoxygenase–Activating Protein Involves HIF-1a and NF-kB andMicroRNAs 135a and 199a-5pCaryn S. Gonsalves and Vijay K. Kalra

3889 Neutrophil Transmigration Mediated by the Neutrophil-Specific Antigen CD177 Is Influenced by theEndothelial S536N Dimorphism of Platelet Endothelial Cell Adhesion Molecule-1Behnaz Bayat, Silke Werth, Ulrich J. H. Sachs, Debra K. Newman, Peter J. Newman, and Sentot Santoso

3897 Constitutive Association of TGF-b–Activated Kinase 1 with the IkB Kinase Complex in the Nucleus andCytoplasm of Human Neutrophils and Its Impact on Downstream ProcessesThornin Ear, Carl F. Fortin, Francois A. Simard, and Patrick P. McDonald

3907 Induction of IDO-1 by Immunostimulatory DNA Limits Severity of Experimental ColitisMatthew A. Ciorba, Ellen E. Bettonville, Keely G. McDonald, Richard Metz, George C. Prendergast, Rodney D. Newberry,

and William F. Stenson

3917 An LFA-1 (aLb2) Small-Molecule Antagonist Reduces Inflammation and Joint Destruction in MurineModels of ArthritisSuzanne J. Suchard, Dawn K. Stetsko, Patricia M. Davis, Stacey Skala, Dominique Potin,

Michele Launay, T. G. Murali Dhar, Joel C. Barrish, Vojkan Susulic, David J. Shuster, Kim W. McIntyre,

Murray McKinnon, and Luisa Salter-Cid

3927 Fatty Acids from Very Low-Density Lipoprotein Lipolysis Products Induce Lipid Droplet Accumulation inHuman MonocytesLaura J. den Hartigh, Jaime E. Connolly-Rohrbach, Samantha Fore, Thomas R. Huser, and John C. Rutledge

3937 Identification of New Pathogenic Players in Lupus: Autoantibody-Secreting Cells Are Present in NephriticKidneys of (NZBxNZW)F1 MiceSt�ephanie Lacotte, H�el�ene Dumortier, Marion D�ecossas, Jean-Paul Briand, and Sylviane Muller

3946 Proinflammatory Cytokine IL-1b Stimulates IL-8 Synthesis in Mast Cells via a Leukotriene B4 Receptor2-Linked Pathway, Contributing to AngiogenesisGeun-Young Kim, Jin-Wook Lee, Ho-Cheol Ryu, Jun-Dong Wei, Chu-Myong Seong, and Jae-Hong Kim

3955 Matrix Metalloproteinase 12-Deficiency Augments Extracellular Matrix Degrading Metalloproteinases andAttenuates IL-13–Dependent FibrosisSatish K. Madala, John T. Pesce, Thirumalai R. Ramalingam, Mark S. Wilson, Samantha Minnicozzi, Allen W. Cheever,

Robert W. Thompson, Margaret M. Mentink-Kane, and Thomas A. Wynn

3964 Differential Roles of Macrophages in Diverse Phases of Skin RepairTina Lucas, Ari Waisman, Rajeev Ranjan, J€urgen Roes, Thomas Krieg, Werner M€uller, Axel Roers, and Sabine A. Eming

3978 5-Lipoxygenase Activating Protein Signals Adipose Tissue Inflammation and Lipid Dysfunction inExperimental ObesityRaquel Horrillo, Ana Gonz�alez-P�eriz, Marcos Martinez-Clemente, Marta L�opez-Parra, Nat�alia Ferr�e, Esther Titos,

Eva Mor�an-Salvador, Ramon Deulofeu, Vicente Arroyo, and Joan Cl�aria

CLINICAL IMMUNOLOGY3988 Clcn5 Knockout Mice Exhibit Novel Immunomodulatory Effects and Are More Susceptible to Dextran

Sulfate Sodium-Induced ColitisPhilip Alex, Mei Ye, Nicholas C. Zachos, Jennifer Sipes, Thuan Nguyen, Maxim Suhodrev, Liberty Gonzales, Zubin Arora,

Ting Zhang, Michael Centola, Sandra E. Guggino, and Xuhang Li

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3997 IL-1 Receptor Antagonist Protects against Placental and Neurodevelopmental Defects Induced by MaternalInflammationSylvie Girard, Luc Tremblay, Martin Lepage, and Guillaume S�ebire

4006 B Cells Are Required for Optimal CD4+ and CD8+ T Cell Tumor Immunity: Therapeutic B CellDepletion Enhances B16 Melanoma Growth in MiceDavid J. DiLillo, Koichi Yanaba, and Thomas F. Tedder

4017 SP1-Dependent Induction of CD39 Facilitates Hepatic Ischemic PreconditioningMelanie L. Hart, Iris C. Gorzolla, Jens Schittenhelm, Simon C. Robson, and Holger K. Eltzschig

4025 Cleavage of Transaldolase by Granzyme B Causes the Loss of Enzymatic Activity with Retention ofAntigenicity for Multiple Sclerosis PatientsBrian Niland, Gabriella Miklossy, Katalin Banki, William E. Biddison, Livia Casciola-Rosen, Antony Rosen,

Denis Martinvalet, Judy Lieberman, and Andras Perl

4033 Coordinate Interaction between IL-13 and Epithelial Differentiation Cluster Genes in EosinophilicEsophagitisCarine Blanchard, Emily M. Stucke, Karen Burwinkel, Julie M. Caldwell, Margaret H. Collins, Annette Ahrens,

Bridget K. Buckmeier, Sean C. Jameson, Allison Greenberg, Ajay Kaul, James P. Franciosi, Jonathan P. Kushner,

Lisa J. Martin, Philip E. Putnam, J. Pablo Abonia, Suzanne I. Wells, and Marc E. Rothenberg

LETTERS OF RETRACTION4042 Retraction: Activation of Human Oral Epithelial Cells by Neutrophil Proteinase 3 Through

Protease-Activated Receptor-2Shunji Sugawara and Koji Muramoto

4043 Retraction: Neutrophil Serine Proteinases Activate Human Nonepithelial Cells to Produce InflammatoryCytokines Through Protease-Activated Receptor 2Koji Muramoto and Shunji Sugawara

4044 Retraction: Proinflammatory Cytokines Induce Proteinase 3 as Membrane-Bound and Secretory Forms inHuman Oral Epithelial Cells and Antibodies to Proteinase 3 Activate the Cells through Protease-ActivatedReceptor-2Yumiko Sugawara, Takashi Sasano, and Shunji Sugawara

AUTHOR INDEX4045

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