GRA 2012 Annual meeting

• Meeting opening

• President’s address

Inclusive Innovation and Healthcare

Third Asia Think Tank Summit

Inclusive Knowledge Partnerships for Development

Gerald Hane

Sushil Borde

Raghunath Mashelkar

GRA Colleagues

May 22, 2015

Disclaimer: The views expressed in this paper/presentation are the views of the author and do

not necessarily reflect the views or policies of the Asian Development Bank (ADB), or its Board

of Governors, or the governments they represent. ADB does not guarantee the accuracy of the

data included in this paper and accepts no responsibility for any consequence of their use.

Terminology used may not necessarily be consistent with ADB official terms.

The Global Research Alliance (GRA) is:

• a collaboration of eight of the world’s leading applied-research agencies

• using the best science and technology

• working to solve some of the biggest challenges in the developing world

Who we are

GRA Member Organizations

Battelle (USA)

Fraunhofer-Gesellschaft (Germany)

SIRIM Berhad (Malaysia)

Netherlands Organisation for Applied Scientific Research (Netherlands)

VTT Technical Research Centre (Finland)

Commonwealth Scientific and Industrial Research Organisation (Australia)

Danish Technological Institute (Denmark)

Council of Scientific and Industrial Research (India)

What we do

The GRA’s vision is for a world where the

application of innovative science and technology,

through collaboration and co-creation, delivers

access equality, improves lives and solves global

development challenges.

ICT

Energy

Water

Health Food

Our focus – global research for global good

Inclusive Innovation – GRA approach

“Inclusive Innovation is any innovation that leads to

affordable access of quality goods and services

creating livelihood opportunities for the excluded

population, primarily at the base of the pyramid,

and on a long term sustainable basis with a

significant outreach”.

Dr Ramesh Mashelkar

GRA President

Getting more, from less, for more

Inclusive Innovation – access equality despite income inequality

Income Inequality 10,000:1

Access Equality 1:1

Inclusive Innovation – our philosophy

We undertake:

research for development

Because:

We believe in

‘Inclusive Innovation’

We aspire to build:

• Self-reliance

• Economic benefits

• Social inclusion

by ….. Making a

difference Mobilising

the best

team

Defining the

need and

relevance

Partnering

for impact

Outline for Today

Growing Capabilites in Advances in Science, Technology and

Innovation Enable a Growing Basket of Inclusive Options

Innovative Technology

• Higher performance materials – lighter weight, durable,

environmentally sound, low cost

• Advanced sensors and diagnostics

• Innovative devices

• IT to enable broad impact – the “Internet of things”

Innovative Business Models and Market Approaches

• Lost cost manufacturing with efficient service workflow

• Cost efficient certification for broader markets

• Open discovery

Growing Global Interest

• World Bank – Inclusive Innovation

• Organization for Economic Cooperation and

Development (OECD) – Innovation for Inclusive

Growth

• European Union – Horizon 2020 Programme

• APEC

• Growing number of national aid organizations

THREE PRIORITY THEMES

Traditional Herbal Medicine

Information/Communication Technology

Agriculture/Aquaculture

CHUNG TAY SÁNG TẠO PHÁT TRIỂN CỘNG ĐỒNG

VIETNAM INCLUSIVE INNOVATION PROJECT ( VIIP)

Examples of Inclusive Innovation

Jaipur Foot, Jaipur Knee

$28 Foot And

$20 Knee

Non-Invasive Blood Test for Anemia TouchHb

• Optical sensor

provides a reading in

60 seconds and

eliminates the need for

needles, lancets,

micro-cuvettes, blotting

paper, etc.

• Based on

photoplethysmography,

spectrophotometry,

and photon scattering

software

BLISS4Midwives Improving maternal health in rural Africa TNO, Netherlands • Enable integrated diagnostics for

community health nurses and midwives

• Improve therapy tailored to skills, availability and mandate

• Improve referral pathways connecting CHN, midwives, laboratory and hospital

• Decentralized point of care

diagnostics of most important

parameters

• Robust & ease of use

• Concerning 42% of maternal death

causes

4 May 2015

BLISS4Midwives

Decision support app

Non-invasive Hb

Urine strips - Glucose - Protein

Blood pressure

Anemia

Pre-eclampsia

Gestational Diabetes

User instructions

Commcare cloud

Awareness

Nutrition

Referrals

Therapy

Paper-based Diagnostics and Lab-on-a-Chip

• Paper-based diagnostics based

on micro-fluidics

• Directs fluids such as blood,

saliva, urine though assay

channels that change colors

• Assessment of liver health in 15

minutes

DNA Based Diagnostic Chip for

Eye infection

Recognized as the product of the year-2008

and received Asia-Pacific Biotechnology

award (As a product of unmet need)

CSIR - 800 : Affordable Health Care

Micro PCR

Advanced and Affordable Diagnostics

• Rapid detection of Hepatitis-B Virus

• Targeted for deployment at Rural health

care centres and designed for use by

minimally skilled personnel

• Patents : US and PCT

• Detection of 14 Pathogen causing

ophthalmic infections

• Rapid Diagnosis of Pathogens

simultaneously

• Early treatment of infection to avoid

loss of vision – diagnosis within 6 hrs

as against 72 hrs leads to right

prescription

Micro PCR would create Global

technological niche

Affordable Infant Warmer Embrace

• Entrepreneurial Design for Extreme Affordability – Stanford University

• Nearly 3 million babies die every year in the first 28 days within birth. Up to 50% deaths occur during their very first 24 hours of life while 75% occur in the first week. The 48 hours immediately following birth are the most crucial for newborn survival .

• Less than 1 percent the cost of a conventional infant incubator.

Safe Surgery Sterilizer Solarclave

• This low-cost, solar-powered

autoclave offers rural health

facilities the ability to sterilize

instruments on-site.

• A reflector that concentrates the

sun’s rays and a pressure

vessel that holds the surgical

instruments and receives the

focused solar energy.

• The total cost of materials is

estimated to be US$ 150 with

95% materials sourced locally

(deployment in Nicaragua).

• A diagnostic tool that operates remotely to capture patient data and transmit it over a very low bandwidth (upward of 32Kb/sec).

• The devices consume very little battery power – only 2 watts – through a USB port to capture and transmit each patient’s vitals such as blood pressure, heart sounds, electrocardiograph, oxygen saturation, and body temperature.

• Deployed in health kiosks in India.

Medical Data Acquisition Unit ReMeDi®

Innovative Business Model:

Aravind Eye Care

• 3.3 million eye tests and 300,000 cataract surgeries

per year

• Low cost ($5) lens manufacturing joint venture

• Extreme efficiency through workflow innovation

• Research and training institutes

• Civil society groups that organize patient screening

events in rural villages

• US$40 cost of treatment

• 66 percent of patients treated for free

Harnessing Traditional Medicine –

Reverse Pharmacology

• Argemone Mexicana is a plant that contains many alkaloids.

• Use clinical experiences and qualitative experiences to develop treatment candidates

• No affect on animals, therefore animal testing would have been inconclusive.

• Subjects treated and tested for malaria-causing parasites in their blood

• Substantial decrease seen over 7 days

Open Source Drug Discovery (OSDD) Model “CSIR led Team India Consortium with International Participation”

Council of Scientific and

Industrial Research (CSIR), India

Current Partners

Mycobacterium tuberculosis

Wiki Portal

Exchange of Ideas/Results

Community Participation

Lead

Molecules Drug

Contract

Research

Organisations

Academia

& Hospitals

Open Synthesis and

Exchange

of Knowledge

PRECLINICAL &

CLINICAL TRIAL

Candidate

Targets

in silico SCREENING

in vivo VALIDATION

Lead Organization

How labs can help

• Technology transfer

• Capacity building

• Country specific analyses

• Program design and management

GRA 2012 Annual meeting

• Meeting opening

• President’s address

Thank you

Gerald Hane

Battelle Memorial Institute

haneg@battelle.org