Increased Toll-Like Receptor Activity in Patients With Metabolic Syndrome

Featured Article:

Ishwarlal Jialal, M.D., Ph.D., Beverley A. Huet, Ph.D., Harmeet Kaur, Ph.D., Alexander Chien, B.S., Sridevi Devaraj, Ph.D.

Diabetes Care Volume 35: 900-904

April, 2012

Study Objective

• Metabolic syndrome (MetS) is a proinflammatory state, but there is a paucity of data on cellular inflammation in MetS

 • Toll-like receptors (TLRs) are classical pattern recognition

receptors of the innate immune response • Aim of study was to compare monocyte TLR2 and TLR4

between MetS patients and control subjects

Jialal I et al. Diabetes Care 2012;35:900-904

Study Design

• Fasting blood obtained for TLR expression and activity • Participants with MetS but no CVD or diabetes compared to

control participants

Jialal I et al. Diabetes Care 2012;35:900-904

Jialal I et al. Diabetes Care 2012;35:900-904

Jialal I et al. Diabetes Care 2012;35:900-904

Jialal I et al. Diabetes Care 2012;35:900-904

Conclusions

• Both TLR2 and TLR4 expression and activity are increased in the monocytes of patients with MetS

 • This could contribute to increased risk for diabetes and CVD

with MetS

Jialal I et al. Diabetes Care 2012;35:900-904