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Page 1: · PDF fileHEALTHFOODINGREDIENTS Indenaleveragesitssolidpharmaceucalbackground forthehealthfoodfield,developingbiologicallyacve ingredientsforsupplements,funconal

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Page 4: · PDF fileHEALTHFOODINGREDIENTS Indenaleveragesitssolidpharmaceucalbackground forthehealthfoodfield,developingbiologicallyacve ingredientsforsupplements,funconal

800  employees  5  interna<onal  branches  5  produc<on  sites  worldwide  sales  in  more  than  70  countries  more  than  120  primary  patents  

FACTS  &    

FIGURES  

Page 5: · PDF fileHEALTHFOODINGREDIENTS Indenaleveragesitssolidpharmaceucalbackground forthehealthfoodfield,developingbiologicallyacve ingredientsforsupplements,funconal

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Page 6: · PDF fileHEALTHFOODINGREDIENTS Indenaleveragesitssolidpharmaceucalbackground forthehealthfoodfield,developingbiologicallyacve ingredientsforsupplements,funconal

Dedicated areas

Purification

Plantations

GACP

Micropropagation

Pre-clinical

Screening ICH

HACCP

FDA cGMP

OECD

AIFA

Processes

Extraction

Clinical

Products

Biodiversity

Isolation

ANSM

QUALITY,SAFETY

& EFFICACY

RESEARCH

BOTANICALEXPERTISE SCALE UP

& INDUSTRIALPRODUCTION

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Page 16: · PDF fileHEALTHFOODINGREDIENTS Indenaleveragesitssolidpharmaceucalbackground forthehealthfoodfield,developingbiologicallyacve ingredientsforsupplements,funconal

ACTIVE  PHARMACEUTICAL    INGREDIENTS  Isolated  or  semisynthe<c  pure  products  and  extracts    are  produced  in  compliance  with  cGMPs  and  supported  by  CTD-­‐DMFs.    Among  our  main  products:  

PACLITAXEL    Taxus  media  Rehder  -­‐  Root,  Leaf  and  Twig  -­‐  ≥97.0%  ≤102.0%  by  HPLC  -­‐  An<cancer.    10-­‐DAB  III    Taxus  baccata  L.  -­‐  Twig  and  leaf  -­‐  ≥96.0%  by  HPLC  -­‐  Chemical  intermediate.    THIOCOLCHICOSIDE  Gloriosa  superba    L.  -­‐  Seed  -­‐  ≥98.0%  ≤102.0%  by  poten<ometry  -­‐  Muscle  relaxant.    COLCHICINE  Gloriosa  superba    L.  -­‐  Seed  -­‐  ≥97.0%  ≤102.0%  by  poten<ometry  -­‐  An<gout.    DOCETAXEL    Taxus  baccata    L.  -­‐  Twig  and  leaf  -­‐    ≥97.0%  ≤102.0%  by  HPLC  -­‐  An<cancer.    MYRTOCYAN®    Vaccinium  myr6llus    L.  -­‐  Fresh  frozen  fruit  -­‐  ≥32.4%  ≤39.6%  by  HPLC  -­‐  Capillarotropic.    ESCIN    Aesculus  hippocastanum    L.  -­‐  Seed  -­‐  ≥97.0%  ≤103.0%  by  poten<ometry  -­‐  An<oedema.    GINKGO  BILOBA  Ginkgo  biloba    L.  -­‐  Leaf  -­‐  ≥22.0%  ≤27.0%  of  flavonoids  by  HPLC,  ≥2.6%  ≤3.2%  of  bilobalide    by  HPLC,  ≥2.8%  ≤3.4%  of  ginkgolides  A,B,C  by  HPLC,  ≤5  ppm  of  ginkgolic  acids  by  HPLC  -­‐  Blood  circula<on  improver.  

Page 17: · PDF fileHEALTHFOODINGREDIENTS Indenaleveragesitssolidpharmaceucalbackground forthehealthfoodfield,developingbiologicallyacve ingredientsforsupplements,funconal

HEALTH-­‐FOOD  INGREDIENTS  Indena  leverages  its  solid  pharmaceu<cal  background    for  the  health-­‐food  field,  developing  biologically  ac<ve    ingredients  for  supplements,  func<onal,  medical  and  baby  food  products  for  more  than  40  years.  These  include:  

MIRTOSELECT®    Vaccinium  myr6llus    L.  -­‐  Fresh  frozen  fruit  -­‐  ≥36.0%  of  anthocyanins  by  HPLC  -­‐  ≥25.0%  anthocyanins  as  anthocyanidins  by  spectrophotometry  -­‐  Eye  health,  Circulatory  health,  An<oxidant  ac<vity.    LEUCOSELECT®    Vi6s  vinifera    L.  -­‐  Seed  -­‐    ≥95.0%  ≤105.0%  of  proanthocyanidins  by  GPC,  ≥13.0%  ≤19.0%  of  catechin  and  epicatechin  by  HPLC  -­‐  An<oxidant  ac<vity,  Circulatory  health.    GREENSELECT®    Camellia  sinensis    (L.)  O.  Kuntze  -­‐  Young  leaf  -­‐  ≥60.0%  of  total  polyphenols,  ≥40.0%  of  (-­‐)-­‐epigallocatechin-­‐3-­‐O-­‐gallate,  ≤0.1%  of  caffeine  by  HPLC  -­‐  An<oxidant  ac<vity.    OPEXTAN®  Olea  europaea  L.  -­‐  Fruit  -­‐  ≥10.0%  of  total  polyphenols  by  spectrophotometry,  ≥2.0%  ≤3.5%  of  verbascoside  by  HPLC,  ≥4.5%  of  hydroxytyrosol  and  its  deriva<ves  by  HPLC  -­‐  An<oxidant  ac<vity,  Healthy  skin,  Healthy  cardiovascular  func<on.    BEANBLOCK®  Phaseolus  vulgaris    L.  -­‐  Common  bean  -­‐  ≥6.0%  as  alpha  amylase  inhibitor  by  HPLC  1,100  U/mg  of  alpha  amylase  inhibi<ng  ac<vity,  30,000  HAU/g  of  hemagglu<na<ng  ac<vity  by  spectroph./enzym.  -­‐  Appe<te  regulator,  Healthy  blood  sugar  metabolism.  

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PERSONAL  CARE  INGREDIENTS  Indena  develops  func<onal  ingredients  with  a  wide  range  of  applica<ons  for  “high”  skin  &  hair  care  products,  including:  

ESCIN  Aesculus  hippocastanum    L.  -­‐  Seed  -­‐-­‐  ≥97.0%  ≤103.0%    by  poten<ometry  -­‐  Capillarotropic.    CENTELLA  ASIATICA  TRITERPENES  Centella  asia6ca    (L.)  Urban  -­‐  Leaf  -­‐  ≥36.0%  ≤44.0%  of  asia<coside,  ≥56.0%  ≤64.0%  of  genins  as  sum  of  asia<c  acid  and  madecassic  acid  by  HPLC  -­‐  An<-­‐wrinkles,  Stretchmarks  improver.    RUSCOGENINS    Ruscus  aculeatus    L.  -­‐  Rhizome  and  root  -­‐  ≥92.0%  ≤103.0%  of  ruscogenins,  ≥60.0%  ≤80%  of    neoruscogenin,  ≥20.0%                ≤40.0%  of  ruscogenin  by  HPLC    An<cellulite,  Vasoprotectant.    

CURBILENE®    Cucurbita  pepo    L.  -­‐  Naked  seed  -­‐  ≥85.0%  of  faPy  acids  by  GC  -­‐  Skin  maqng  agent.    ZANTHALENE®    Zanthoxylum  bungeanum    Maxim.  -­‐  Pericarp    -­‐    ≥4.4%  ≤6.4%  of  alkylamides  by  HPLC  -­‐  An<-­‐itching,  Skin  sensi<vity  modulator.    

XILOGEL®    Tamarindus  indica    L.  -­‐  Seed  -­‐  ≥85.0%  by  HPLC  -­‐  Moisturizer,  Skin  restructurant,  An<-­‐wrinkles.    CENTEVITA®    Centella  asia<ca    (L.)  Urban  -­‐  Leaf  -­‐  ≥45.0%  of  the  sum  of  asia<coside,  madecassoside,  asia<c  and  madecassic  acids  by  HPLC  -­‐  Collagen  restructurant  and  an<-­‐glyca<on  agent.    

BOSEXIL®    Boswellia  serrata    Roxb.  ex  Colebr.  -­‐  Resin  -­‐  ≥25.0%  boswellic  acids  by  HPLC  -­‐  Soothing,  An<-­‐photo  ageing.  

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PHYTOSOME®  MORE  BIOAVAILABLE  Indena  has  developed  a  proprietary    technology  to  op<mise  the  bioavailability  of  selected  phytochemicals.      Products  include:  

CASPEROME®  Boswellia  serrata  Roxb.  ex  Colebr.  -­‐  Resin  -­‐  ≥25.0%  boswellic  acids  by  HPLC  -­‐  For  healthy  inflammatory  response.    MERIVA®    Curcuma  longa  L.  -­‐  Rhizome  -­‐  ≥18.0%  ≤22.0%  of  curcuminoids  by  HPLC  -­‐  Joint  health,  For  healthy  inflammatory  response.    SILIPHOS®  Silybum  marianum  L.  Gaertn.  -­‐  Fruit  -­‐  ≥29.7%  ≤36.3%  of  silybin  by  HPLC  -­‐  Healthy  liver.    GREENSELECT®  Camellia  sinensis    (L.)  O.  Kuntze  -­‐  Young  leaf  -­‐  ≥19.0%  ≤25.0%  of  polyphenols  expressed  as  (-­‐)-­‐epigallocatechin-­‐3-­‐O-­‐gallate,  ≥13.0%  of  (-­‐)-­‐epigallocatechin-­‐3-­‐O-­‐gallate,  ≤0.1%  of  caffeine  by  HPLC  -­‐  An<oxidant,  Weight  loss  agent.    LEUCOSELECT®  Vi6s  vinifera    L.  -­‐  Seed  -­‐  ≥25.0%  ≤30.0%  of  proanthocyanidins  by  GPC  -­‐  Cardiovascular  protectant,  UV  protectant,  An<oxidant.    GINKGOSELECT®  Ginkgo  biloba    L.  -­‐  Leaf  -­‐  ≥7.0%  of  ginkgoflavonglucosides,  ≥2.0%  of  ginkgoterpenes,  ≥0.8%  of  bilobalide,  ≥0.8%  of  ginkgolides  by  HPLC  ≤5  ppm  of  total  ginkgolic  acids  by  HPLC  -­‐  Cogni<on  and  circula<on  improver,  An<oxidant,  Vasokine<c.  

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