indigenous software for quantification of autonomic tone
DESCRIPTION
Indigenous software for quantification of autonomic tone. Prof. K K Deepak MD, PhD, MNAMS Professor of Physiology [email protected]. All India Institute of Medical Sciences New Delhi 110029 India. ECG. HRV pattern. Autonomic Control of Function of Heart. PNS. High freq. Aff. Nvs. - PowerPoint PPT PresentationTRANSCRIPT
Indigenous software for quantification of autonomic
tone
Prof. K K Deepak MD, PhD, MNAMS Professor of Physiology [email protected]
All India Institute of Medical SciencesNew Delhi 110029 India
Aut
onom
ic c
ontr
olle
r
PNS
SNS
High freq.
Low freq.
Aff. Nvs.
ECG
Autonomic Control of Function of Heart
HRV pattern
Respiration
Blood Pressure
Cardiac Output
Renin-Angioten.
Thermoregul.
Others inputs Aut
onom
ic c
ontr
olle
r
PNS
SNS
High freq.
Low freq.
Aff. Nvs.
ECG
Autonomic Control of Function of Heart
HRV pattern
• Cardiovascular pathophysiology
• Myocardial Infarction
• Diabetic neuropathy
• Estimation of vagal tone
• Neurological disorders
•Migraine
Applied aspect of Cardiac tone (HRV)Applied aspect of Cardiac tone (HRV)
•MSA
• Assessment of neonatal ANS
• Hypertension
• Cardiac Transplant Rejection
• End organ failure
• Hypertension
• Hypertensive Pregnancy Disorders
Applied aspect of vascular tone (BPV)Applied aspect of vascular tone (BPV)
• Risk factor for stroke / SCD / SIDS
• Prognosis in CHF
Autonomic Tone (HRV) in health and disease
Healthy Healthy
Heart Attack Heart transplant
Indigenously Developed HRV Software for the Quantification of Autonomic
ToneObjectives
Software development for measurement of Heart Rate Variability (HRV_Soft) and Blood Pressure Variability (BPV_Soft)
Offline Data Analysis
Online Data Acquisition
Done
Done
Done
Development & Acquisition Tools Used
1. National Instruments USB-6008 DAQ
2. National Instruments (NI) Labview FDS 8.0
3. NI Measurement and Automation Libraries
1) Colin BP-508 BP Monitor 2) Finapres Ohmeda 2300 BP Monitor3) DAS port (Nevrokard)4) Analog ECG from any source
Patient
DAQ Module
(USB Based)
Analysis & Storage
Signal Source Flow Diagram
Blood Pressure
ECG
HRV_Soft
BPV_Soft
Main Panel of Indigenously Developed Software (HRV_Soft)
Heart Rate Variability
Validation of our HRV_Soft & studies carried out
• We acquired the ECG and BP Signal from the Nevrokard DAS port and FINAPRES simultaneously on our Software and Nevrokard Software.
• We compared the Time Domain, Frequency Domain & Non Linear Parameters
• The results were found to be Statistically comparable
Testing Model 1
AnalysisAnalysis
Analog Signal Acquisition
Nevrokard
Digitization Digitization
Analog Signal Acquisition
Single patient source (ECG)
HRV_Soft
Time Domain Parameters
Mean
894.17 894.32
0.00
200.00
400.00
600.00
800.00
1000.00
Nevrokard Our Software
Varaince
2196.30 2178.49
0.00
1000.00
2000.00
3000.00
Nevrokard Our Software
NN50 Count
25.39
30.82
0.00
10.00
20.00
30.00
40.00
Our SoftwareNevrokard
SDNN
42.19 42.15
0.00
10.00
20.00
30.00
40.00
50.00
Our SoftwareNevrokard
RMSDD
36.85 36.58
0.00
10.00
20.00
30.00
40.00
50.00
Our SoftwareNevrokard
N=22
SDANN
36.86 36.63
0.00
10.00
20.00
30.00
40.00
50.00
Our SoftwareNevrokard
FREQUENCY DOMAIN PARAMETERS
LF/HF
2.00 1.98
0.00
0.50
1.00
1.50
2.00
2.50
Our SoftwareNevrokard
% VLF
37.10 38.77
0.00
10.00
20.00
30.00
40.00
Our SoftwareNevrokard
% LF
32.76 34.46
0.00
10.00
20.00
30.00
40.00
Our SoftwareNevrokard
%HF
30.13 29.40
0.00
10.00
20.00
30.00
40.00
Our SoftwareNevrokard
N=22
AnalysisAnalysis
Nevrokard
Digitization & Peak detection by our software
BPV_SoftHRV_Soft
Testing Model 2
Analog Signal Acquisition ( our software)
Patient ECG
Pearson Correlation Test of HRV parameters obtained from 45 subjects as measured from HRV soft and Neurokard
Varaince
2196.30 2178.49
0.00
1000.00
2000.00
3000.00
Nevrokard Our Software
NN50 Count
25.39
30.82
0.00
10.00
20.00
30.00
40.00
Our SoftwareNevrokard
SDNN
42.19 42.15
0.00
10.00
20.00
30.00
40.00
50.00
Our SoftwareNevrokard
RMSDD
36.85 36.58
0.00
10.00
20.00
30.00
40.00
50.00
Our SoftwareNevrokard
LF/HF
2.00 1.98
0.00
0.50
1.00
1.50
2.00
2.50
Our SoftwareNevrokard
% VLF
37.10 38.77
0.00
10.00
20.00
30.00
40.00
Our SoftwareNevrokard
% LF
32.76 34.46
0.00
10.00
20.00
30.00
40.00
Our SoftwareNevrokard
%HF
30.13 29.40
0.00
10.00
20.00
30.00
40.00
Our SoftwareNevrokard
Statistical Parameters r2 rp Value(p<0.05)
Range 0.9995 1.000 0.000
Mean 0.9999 1.000 0.000
Median 0.8862 0.944 0.000
Variance 1.0000 1.000 0.000
VLF% 0.8597 0.928 0.000
LF% 0.9445 0.975 0.000
HF% 0.8855 0.941 0.000
LF(nu) 0.8455 0.920 0.000
HF(nu) 0.8997 0.949 0.000
SD1 1.0000 1.000 0.000
SD2 0.8649 0.959 0.000
SD1/SD2 0.8394 0.957 0.000
One more feature has been developed which can trace the path of Non Linear behavior. This actually analyses the phases of development of Poincare plot.
What is being delivered ?
Unique features of our software
1.Complete report generation in printable format as shown in fig below. Also all the parameter of time frequency & non-linear analysis are transferred to Excel sheet for maintaining Database
2. Additional Parameters than commercially available software. 3.Poincare tracking feature in poincare plot (Non-linear analysis) allows
user to observe point-by-point movement of the plot 4.Provision for deleting artifacts present in the ECG waveform before
performing Peak detection.
5.Robust fully automatic peak detection algorithm.
6.USB/Serial port connectivity & Easy to use Graphical User Interface.
7.Flexible & Cost Effective.
HRV-SoftBPV-Soft
Analog to Digital
Converter
Any device thatcan pick
ECG signals
Any Biological signal:
EEG/ EMG/ENG/
Resp/ EGG/ ICG
Any device thatcan record
Continuous BP
Compatibility with existing systems
General compatibility
2007
1996 2004
2002