Inference of Genealogies for Recombinant SNP Sequences in Populations

Yufeng Wu

Computer Science and Engineering Department

University of Connecticut

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Prefix

Suffix

11000 0000001111

Breakpoint

Recombination: One of the principle genetic forces shaping sequence variations within species

Genealogical History with Recombination

10 01 00

S1 = 00S2 = 01S3 = 10S4 = 10

Mutations

S1 = 00S2 = 01S3 = 10S4 = 11

10 01 0011

Recombination

Assumption:

At most one mutation per site

1 0 0 1

1 1

00

10

3

At which Marginal Tree Did Disease Mutations Occur?

Use of inferred genealogical history in mapping complex traits

Case Control

Possible Disease mutation

Research Topics related to Recombination

• Estimate the level of recombination in genomic regions.

• Infer the genealogical history with recombination.• Mapping causative loci for complex traits using

inferred genealogical history• Computation of likelihood and estimation of

population genetic parameters.

Research supported by NSF and UConn Research Foundation.

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