inflammation and immune response jerry axsom
TRANSCRIPT
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Inflammation and Inflammation and Immune responseImmune response
Jerry AxsomJerry Axsom
HM2/ NREMT-PHM2/ NREMT-P
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Purpose of Inflammation and Purpose of Inflammation and immunutyimmunuty
to protect the body from micro-to protect the body from micro-organismsorganisms
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Invading cells and micro organisms Invading cells and micro organisms are foreign proteins called Antigensare foreign proteins called Antigens
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The bone marrow is the source of all The bone marrow is the source of all blood cellsblood cells
Including the cells of the immune Including the cells of the immune systemsystem
They are formed there and released They are formed there and released into the blood streaminto the blood stream
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Bone marrow cells start out as stem Bone marrow cells start out as stem cells, then mature into specific cellscells, then mature into specific cells
The immune system cells start are The immune system cells start are white blood cells or leukocyteswhite blood cells or leukocytes
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The immune process requires 3 The immune process requires 3 responsesresponses
1.) inflammation1.) inflammation 2.) antibody-mediated 2.) antibody-mediated
immunity( humoral immunity)immunity( humoral immunity) 3.) cell- mediated immunity3.) cell- mediated immunity
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InflammationInflammation
It is immediateIt is immediate It offers short-term protectionIt offers short-term protection It is a non-specific defenceIt is a non-specific defence
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Inflammation differs from antibody- Inflammation differs from antibody- mediated immunity and cell- mediated immunity and cell- mediated immunity in several waysmediated immunity in several ways
Inflammation can occur without Inflammation can occur without infectioninfection
Infection is usually accompanied by Infection is usually accompanied by inflammationinflammation
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Cells involved in inflammationCells involved in inflammation
Leukocutes involved in inflammationLeukocutes involved in inflammation NeutrophilsNeutrophils MacrophagesMacrophages EosinophilsEosinophils BasophilsBasophils
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NeutrophilsNeutrophils
ACCOUNT FOR 67% Of WBCACCOUNT FOR 67% Of WBC Function: phagocytosis of foreign Function: phagocytosis of foreign
protiensprotiens Mature neutrophils are called segs, Mature neutrophils are called segs,
polyspolys Immature neuts are called bands, Immature neuts are called bands,
stabsstabs
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NeutrophilsNeutrophils
Neuts are the first line of defenceNeuts are the first line of defence Neuts take about 12-14 days to Neuts take about 12-14 days to
maturemature Only live about 12-18 hrsOnly live about 12-18 hrs Only take part in one episode of Only take part in one episode of
phagocytosisphagocytosis
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NeutrophilsNeutrophils
A left shift in the WBC refers to an A left shift in the WBC refers to an increase in immature neutsincrease in immature neuts
It also refers to a bacterial infectionIt also refers to a bacterial infection
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MonocytesMonocytes
3% of WBC3% of WBC When matured they are called When matured they are called
MacrophagesMacrophages Can live for months to yearsCan live for months to years Can be involved in multiple episodes Can be involved in multiple episodes
of phagocytosisof phagocytosis
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EosinophilsEosinophils
1.5% of WBC1.5% of WBC Main function: to release chemicals Main function: to release chemicals
which control inflammationwhich control inflammation Elevated in allergic reactions/ Elevated in allergic reactions/
parasitic infectionsparasitic infections
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BasophilsBasophils
.5% of WBC.5% of WBC Responsible for s/s of inflammationResponsible for s/s of inflammation
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PhagocytosisPhagocytosis
1.) exposure1.) exposure 2.) attraction2.) attraction 3.) adherence3.) adherence 4.) recognition4.) recognition 5.) cellular ingestion5.) cellular ingestion 6.) phagosome formation6.) phagosome formation 7.) degration7.) degration
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Stages of inflammationStages of inflammation
Manifestations of inflammationManifestations of inflammation WarmthWarmth RednessRedness SwellingSwelling PainPain Decreased functionDecreased function
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Stage 1Stage 1
Phase 1- rapid short term blood Phase 1- rapid short term blood vessel constrictionvessel constriction
Phase 2- vascular (blood vessels)Phase 2- vascular (blood vessels) Increased blood flow to areaIncreased blood flow to area Increased capillary permeabilityIncreased capillary permeability s/s warmth, redness, swelling, pains/s warmth, redness, swelling, pain
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Stage 2Stage 2
Cellular exudate stageCellular exudate stage Formation of exudate (pus)Formation of exudate (pus) Most active WBC in this stage are the Most active WBC in this stage are the
NEUTSNEUTS NEUTS attack and destroy foreign NEUTS attack and destroy foreign
substancessubstances
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Stage 3Stage 3
Tissue repair and replacement stageTissue repair and replacement stage
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Antibody- mediated immunityAntibody- mediated immunity(humoral immunity)(humoral immunity)
Involves antigen- antibody Involves antigen- antibody interaction to destroy foreign interaction to destroy foreign protiensprotiens
The leukocyte with the most active The leukocyte with the most active role in humoral immunity is the B- role in humoral immunity is the B- lymphocytelymphocyte
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B- lymphocyteB- lymphocyte
Fromed from stem cells in the bone Fromed from stem cells in the bone marrowmarrow
Released into the bloodReleased into the blood Mature in the spleen, lymph nodes, Mature in the spleen, lymph nodes,
tonsils, and intestinal tracttonsils, and intestinal tract
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Acquiring immunityAcquiring immunity
Immunity can be natural or acquiredImmunity can be natural or acquired
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Adaptive (acquired ) immunityAdaptive (acquired ) immunity
Can be active or passiveCan be active or passive Can be natural or artificialCan be natural or artificial
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ActiveActive
From our own antibodiesFrom our own antibodies Can be natural or artificalCan be natural or artifical Long term immunityLong term immunity
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ActiveActive
Natural/ active: active- antigen/ Natural/ active: active- antigen/ antibody responseantibody response
Ex: person has measlesEx: person has measles
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ActiveActive
Artificial/ activeArtificial/ active active- antigen/antibody responseactive- antigen/antibody response Ex: vaccine for measlesEx: vaccine for measles
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PassivePassive
Natural/ passive: mother to fetusNatural/ passive: mother to fetus Artifical/ passive: antibodies are Artifical/ passive: antibodies are
injectedinjected Ex: tetnus shotEx: tetnus shot
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Cell mediated immunityCell mediated immunity
Lymphocytes 28% of WBCLymphocytes 28% of WBC shift to right = viral infectionshift to right = viral infection main lymp T-lympmain lymp T-lymp Cell mediated immunity involves the Cell mediated immunity involves the
ability to differentiate self from non ability to differentiate self from non selfself
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Cell mediated immunityCell mediated immunity
Natural killer cells destroy cells from Natural killer cells destroy cells from other people or animals. This results other people or animals. This results in rejection of transplanted organs/ in rejection of transplanted organs/ tissuestissues
These people need to take These people need to take immunosuppressants or anti immunosuppressants or anti rejection medsrejection meds
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Connective tissuesConnective tissues
Connective tissue disorders are auto Connective tissue disorders are auto immune disorders that cause chronic immune disorders that cause chronic pain, loss of function, and are pain, loss of function, and are cripplingcrippling
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OsteoarthritisOsteoarthritis
NoninflammatoryNoninflammatory Non systemicNon systemic Not auto immuneNot auto immune Joints lose cartilage and rub on each Joints lose cartilage and rub on each
other, may have bone sours, or other, may have bone sours, or subluxation (dislocation)subluxation (dislocation)
Also have crepitusAlso have crepitus Or ballottment “ floating patella”Or ballottment “ floating patella”
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OAOA
Total hipTotal hip most common joint replacedmost common joint replaced can last about 20 yearscan last about 20 years
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Rheumatoid ArthritisRheumatoid Arthritis
Most common connective tissue Most common connective tissue disease and is most destructive to disease and is most destructive to jointsjoints
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RARA
Chronic, progressive, systematic, Chronic, progressive, systematic, inflammatory auto immune diseaseinflammatory auto immune disease
Antibodies (RF’s) are formed and Antibodies (RF’s) are formed and attack healthy tissueattack healthy tissue
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RARA
RA is caused by a combination of RA is caused by a combination of genetic and environmental factors genetic and environmental factors not clearly understoodnot clearly understood
With RA you usually feel better with With RA you usually feel better with activitry unlike OAactivitry unlike OA
Pattern of joint involvement is Pattern of joint involvement is typically bilateral and symmetrictypically bilateral and symmetric
Pain, decreased ROM, joints feel like Pain, decreased ROM, joints feel like jellyjelly
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Lupus erythematosusLupus erythematosus
Discoid lupus erythematosus(DLE)= Discoid lupus erythematosus(DLE)= butterfly rash on facebutterfly rash on face
SLE- chronic, progressive, SLE- chronic, progressive, inflammatory connective tissue inflammatory connective tissue disorder that attacks major body disorder that attacks major body tissuestissues
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GoutGout
Systemic disease which urate Systemic disease which urate crystals deposit in the joints causing crystals deposit in the joints causing inflammationinflammation
Primary gout: most common, an end Primary gout: most common, an end product of this metabolism is uric product of this metabolism is uric acid, which is usually excreted by the acid, which is usually excreted by the kidneyskidneys
The acid is deposited in the The acid is deposited in the synoviumsynovium
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FibromyalgiaFibromyalgia
Chronic pain syndrome, not Chronic pain syndrome, not inflammatory diseaseinflammatory disease
Unknown what causes disease, Unknown what causes disease, though to be a dysfunction in the though to be a dysfunction in the brain r/t pain centerbrain r/t pain center