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Kinase Phosphatase Ligand Transcription Factor Other Receptor Phospho Activation
Membrane Cell Function Binding/Association
Activation Inhibition Indirect Effect Dissociation
P
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p-CREB-1 GSK3 alpha p-JNK123 (Thr183 + 185) p-c-Fos p-STAT3 tyr705
IF | Rat brain IHC-P | Rat brain WB | Mouse brain IHC-P | Mouse osteosarcoma FCM | Human melanoma
P P P P P P P PP
TRAF6
RAC
MKP
HSP27
MKP
Stress Response
P
Growth, development, proliferation Inflammation, apoptosis, differentiation, proliferation
JNK 1/2/3
Cell Membrane
Growth Factors
RTK
Shc Grb2 SOS RasSRC
αγ
β
Raf B-RafA-Raf
MEK1/2
ERK1/2
DAPK
RSK
GSK3
IKBα
p38
Bim
MEK4/7
MAP3K4/12
ASK1 TAK1
IRAK1
IRAK4
MK2
β-arrestin
MEK3/6
c-FOS STAT ELK c-JUN c-JUN CREB ATF2 SP-1 c-MYC
P
P
P
P
P P P
P
P
P
P
P
P
P
P
Activated GPCR
Stress (UV irradiation)Inflammatory cytokines
P
B I O S S P AT H W AY S
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