ingredient breakdown-updated.pdf

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Joylent is a ready to drink milkshake mix in powdered form to be mixed with water, with sweetener and added vitamins and minerals. Instructions for use: Mix 173g (3.5 scoops) of Joylent with 500ml water. Every bag contains 3 servings. Ingredients: oatmeal (gluten), Joylent Vitamix [Maltodextrin, Trisodium citrate * 2H2O, Sodium chloride, L- Choline bitartrate, Calcium carbonate (precipitated), Magnesium oxide (heavy),Vitamin C (ascorbic acid), Vitamin E 50% (dl-alpha-tocopheryl acetate, 500 IU), Niacin (niacinamide), Vitamin A (retinol acetate) 325000 IU, Pantothenic acid (calcium-D- pantothenate), Vitamin D3, Copper sulphate, Vitamin K1 5%,Vitamin B1 (thiamine mononitrate), Vitamin B6 (pyridoxine hydrochloride), Vitamin B2 (riboflavin), Potassium iodate, Chromium chloride, Folic acid, Biotin, Vitamin B12 (cyanocobalamin)], soy flour, whey protein concentrate (cow's milk, lactose, soy lecithin, sucralose, flavor aroma, natural dye, thickener: guar gum), ground flaxseed, flavour enhancer [flash-dried fruit powder (strawberry/banana [5%])/vanilla powder/ raw cacao]. Allergens: may contain traces of nuts (peanuts). Sources: Oatmeal - plant - Avena sativa Whey Protein concentrate - cow milk- animal - cow Soy flour - plant - Glycine max NON GMO ground flaxseed - plant - Linum usitatissimum flash- dried fruit powder (strawberry/banana [5%] - Fragaria × ananassa/Musa acuminata Vanilla powder - plant - V. planifolia Cacao powder - plant - Theobroma cacao

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  • Joylent is a ready to drink milkshake mix in powdered form to be mixed with water, with sweetener and added vitamins and minerals.Instructions for use: Mix 173g (3.5 scoops) of Joylent with 500ml water. Every bag contains 3 servings.Ingredients: oatmeal (gluten), Joylent Vitamix [Maltodextrin, Trisodium citrate * 2H2O, Sodium chloride, L-Choline bitartrate, Calcium carbonate (precipitated), Magnesium oxide (heavy),Vitamin C (ascorbic acid), Vitamin E 50% (dl-alpha-tocopheryl acetate, 500 IU), Niacin (niacinamide), Vitamin A (retinol acetate) 325000 IU, Pantothenic acid (calcium-D- pantothenate), Vitamin D3, Copper sulphate, Vitamin K1 5%,Vitamin B1 (thiamine mononitrate), Vitamin B6 (pyridoxine hydrochloride), Vitamin B2 (riboflavin), Potassium iodate, Chromium chloride, Folic acid, Biotin, Vitamin B12 (cyanocobalamin)], soy flour, whey protein concentrate (cow's milk, lactose, soy lecithin, sucralose, flavor aroma, natural dye, thickener: guar gum), ground flaxseed, flavour enhancer [flash-dried fruit powder (strawberry/banana [5%])/vanilla powder/raw cacao].Allergens: may contain traces of nuts (peanuts).

    Sources:

    Oatmeal - plant - Avena sativa

    Whey Protein concentrate - cow milk- animal - cow

    Soy flour - plant - Glycine max NON GMO

    ground flaxseed - plant - Linum usitatissimum

    flash- dried fruit powder (strawberry/banana [5%] - Fragaria ananassa/Musa acuminata Vanilla powder - plant - V. planifolia

    Cacao powder - plant - Theobroma cacao

  • Vitamin Mix

    Maltodextrin maize or wheat/ maize

    Sodium chloride synthetic flow chartCalcium carbonate (precipitated) synthetic, mineral flow chart

    L-Choline bitartrate synthetic flow chartMagnesium chloride * 6H2O synthetic origin, composition

    Potassium citrateplant (Maize, Sugar Beet), mineral flow chart

    Magnesium oxide (heavy) synthetic flow chart

    Vitamin C (ascorbic acid)vegtable (corn) => fermentation

    Vitamin E 50% (dl-alpha-tocopheryl acetate, 500 IU) vegtable (maize), synthetic

    Potassium iodate synthetic n.a.

    Niacin (niacinamide) synthetic flow chartVitamin A (retinol acetate) 325000 IU

    vegetable( beet sugar, maize, acacia), synthetic) flow chart

    Vitamin D3

    synthetic, vegetable(maize, sugar cane, coconut), animal wool grease (fat) flow chart

    Pantothenic acid (calcium-D-pantothenate) synthetic flow chart

    Folic acid petrochemical flow chart

    Chromium chloride synthetic n.a.

    Biotin synthetic flow chartVitamin B12 (cyanocobalamin) fermentation flow chart

    Vitamin K1 5%synthetic, vegetable(maize, acacia) flow chart

    Vitamin B2 (riboflavin) vegetable (maize starch)

    Copper sulphate synthetic flow chartVitamin B6 (pyridoxine hydrochloride) synthetic

  • Basic flow-chart: SodiumPlant: dsalz GmbH, Bad

    chloride Ph.Eur./UPFried richshal llGermany ffi4ffi W&dgffifu.w

    Rock salt feed

    Dissolving

    Sedimentation

    Evaporation I Crystallisation

    lnsolubles(Clay, anhydrite,magnesium hy-droxide)

    Fines, graineswith oversize

    Rock salt means sodiumchloride with the main naturalimpurities clay and anhydrite

    Dosage of sodium hydroxide(pH regulation) and flocculant

    Dosage of antifoam additive(silicone product)

    Slurry (Sodium chloride / Brine)

    Debrin ing (centrifuges)

    Drying (hot air)

    Cooling (cold air)

    Packaging25 I 50 ks PE baqs,

    Sodium chloride extra pure,without anticaking agent

    {-- Final inspection and test

    Version: 19 May 201O/Dr. Gtzfriedleg

  • Vitamin D3 100 SD

    Emulsification (High-pressure)

    Holding

    Spray Drying

    Sifting

    Packaging

    Preparation of Matrix (water soluble

    components in water)

    Preparation of Oil Phase

    Temperature control

    Screen size

    Production route: Vitamin D3 100 SD

    Nut

    race

    utic

    als

    Pressure control

  • Herstellungsmethode (Calciumcarbonat, schwer, Magnesia 449):

    Calcit

    Zerkleinern

    Trocknen

    Siebung

    Mahlen

    Analysieren, CaCO3

    Verpacken

    Comments on the production process: Only natural Calcium carbonate (CaCO3) from 5 m to 4 6 mm is micronized. Raw material in stones of 10 cm arrives in the main plant from the quarry, 8 km far, and here it starts to be micronized. Micronization takes place in two different lines: technical line and pure line. In the technical line all products for technical market are obtained, while in the pure line only products for both food and pharmaceutical market are manufactured. Both lines are completely closed and separated and no contaminations are possible. Thanks to the dry and friable raw material, during the process no liquids or chemicals are used and only compressed air is used for cleaning machinery. In the process there are three metal detectors. They are able to detect only ferrous materials, whereas for the pure line a glass procedure is in place. The plant works for 24 hours per day, 7 days per week. Maintenance is done during summer time and winter holidays when machinery is off. Controls of critical steps: Raw material: chemical analysis In-process-controls: periodically throughout the manufacturing process; physical analysis and insoluble matter in acetic acid Finished product: chemical and physical analysis

    71805

  • Seed culture in mother bottle culture

    Primary seed culture

    Second seed culture

    Fermentation

    Continuous lysis

    Membrane filtration

    Adsorption in column

    Eluate vacuum concentration

    Transformation Concentration eluate collection

    Fermentation broth Primary acidification

    Zhejiang Medicine Co., Ltd.

    1/1

    Flow Chart of Biotin Pure

    Debenzylation Adjust pH inaqueous layerCheckingmaterials

    Recoveringhydrobromic acid

    Storage inwarehouse

    Storage inPlant

    Receiving byPlant

    Checkingequipments

    Dropping liquidcaustic/Keeping PH Filtration

    Extracting/Demixing

    Crystallization/Centrifugalization

    Refluxing/Filtration MillingDrying Sampling

    Storage inPlant

    Transport tocustomerPackaging

    Storage inwarehouse

    Dibenzyl biotin/Hydrobromic acid

    HB/Methylbenzenesolution

    Water/ Activatedcarbon/EDTA

    Raw material/Packaging material

    Biotin crude

    Test by QC Release byQA

    Extraction

    Water/Methylbenzene Liquid caustic

    Thermalinsulation

    CCP2CCP1

  • Version 05.11, supersedes 04.07 -1/1- TPC_G10_EN

    Production Flow Chart Tripotassium Citrate

    citric acid, potassium source, water

    neutralization crystallization centrifugation

    sieving packaging drying

    Detailed Flow Chart

    A. A1 station:

    NO2

    COCl

    p-nitrobenzoyl chloride

    Alkali liquor Water Monosodium glutamate

    The layer of Toluene

    Hydrochloric acid (Ind. Grade)

    Iron powder

    Ammonium chloride

    Toluene

    Hydrochloric acid (Ind. Grade)

    Condensation

    Reduction

    Recollect

    Distillation

    Stand to delamination

    Adjusting

    Temperature Preservation

    Salt formation

    Filter

    Decolorization

    Filter

  • For information only not for regulatory purposes no update service - August 2005

    Human Nutrition Flow Chart: Dry Vitamin A-Acetate 325 GFP/E Manufacturing site: BASF Health & Nutrition, Denmark

    Atomization

    Emulsion of Vitamin A-Acetate

    Powdering agent Air

    AirDrying

    Mixing of dried batches to standard

    Dry Vitamin A-Acetate 325 GFP/E

    February 2012

    CONFIDENTIAL

    Choline Bitartrate Processing Flow

    Manufacturing site: Balchem Italia srl

    Via del Porto snc 28040 Marano Ticino (NO) Italy

  • JIANGXI TIANXIN PHARMACEUTICAL CO.,LTD

    Add.: Leanjiang Industrial Zone, Leping, Jiangxi, China P.C.: 333300 Tel: +86-798-6702928 Fax: +86-798-6702928 E-mail: [email protected] Website: http://www.txpharm.com

    Page 1 of 2

    Process Chart of Pyridoxine Hydrochloride

    Remark: CCP is the Milling process. Inside the milling machine there is a screen. The integrity of the screen and the remains of material on the screen are inspected and recorded for each batch production.

    Starting materials: 4-methyl-5-ethoxyoxazole, n-propyl dioxepin Flow chart:

    4-Methyl-5-ethoxyoxazole

    n-Propyl dioxepin

    Addition reaction Aromatization

    Hydrolysis Purification Drying

    Milling/Sieving

    Finished product

    Ethanol

    Human Nutrition Flow Chart: Calcium D-Pantothenate Manufacturing site: Ludwigshafen, Germany

    For information only not for regulatory purposes no update service - January 2005

    Crystallisation

    Water

    Methanol

    Calcium D-pantothenate

    Spray drying

    Calcium -alaninate D-pantolactone

  • Manufacturing Flow Chart

    Dry Vitamin K1 5% GFP PRD no. 30041002

    Manufacturing site: BASF A/S, Denmark

    This document, or any answers or information provided herein by BASF, does not constitute a legally binding obligation of BASF.

    While the descriptions, designs, data and information contained herein are presented in good faith and believed to be accurate, it is provided for your information only and not to be used for purposes of pharmaceutical registrations.

    There is no automatic update service for this information.

    SELLER MAKES NO WARRANTY OF ANY KIND; EITHER EXPRESS OR IMPLIED, BY FACT OR LAW, INCLUDING WARRANTIES OF MERCHANTABILITY OR FITNESS FOR PARTICULAR PURPOSE.

    Emulsion of Vitamin K1

    Atomization

    Drying

    Sieving

    Dry Vitamin K1 5% GFP

    Powdering agent Air

    Air

    Version 1, 03.2011

    Flow chart of Niacinamide manufacture process

  • Version 12.07.2012 Kn/VS FS-C46-Et-2.doc

    1 / 1

    METHOD OF MANUFACTURE

    Magnesium Oxide, heavy

    Magnesium Oxide

    Demin. Water

    Suspension

    Purification

    Drying

    Packing

    The raw materials are ordered by the Dr. Paul Lohmann GmbH KG according to internal specifications or pharmacopoeia, controlled by Quality Control and released for production thereafter. Only Demineralised Water is used as a cleansing agent and solvent. The final product is analysed by QC according to methods of specification or pharmacopoeia. If all tests comply with the limits, the material is released for shipment.