ingredient profile review - allysian sciences · ingredient profile review: an abbreviated look at...

Ingredient Profile Review: An abbreviated look at the science supporting the Allysian Mastermind nootropic – a natural health supplement. !!!!

www.allysian.com

!Change a brain, change a life.

www.allysian.com, 1!

!Introducing!Mastermind!!Engineered,by,a,team,of,scientific,and,medical,professionals,,Mastermind,is,Allysian’s,flagship,product,with,19,all>natural,ingredients.,It,is,an,organic,,GMO>free,nootropic,that,helps,increase,memory,,focus,,and,intelligence.,The,ingredient,profile,has,been,validated,by,over,400,clinical,trials,and,136,grade>A,human,studies,to,support,its,claims,(see,complied,references).,,Allysian,has,also,commissioned,a,third>party,organization,to,conduct,independent,third>party,clinical,trials,on,the,Mastermind,formulation.,These,trials,follow,a,strict,‘gold,standard’,protocol,of,a,double>blind,and,placebo,controlled,process,for,accuracy.,Allysian,Mastermind,has,launched,with,a,validated,independent,clinical,trial,prior,to,distribution.,,,The,ingredient,profile,contains,neuro>protective,features,and,is,clinically,proven,to,help,with:,,,

• Attention,and,focus!• Mood!• Mental,fatigue,!• Mental,agility!• Anxiety,and,stress!• Alertness,and,reaction,time!• Learning,and,comprehension!• Social,functioning,!• Working,memory!• Depression!• Fluid,intelligence!

,,,,Brain!Nutrition,The,brain,makes,up,only,two,percent,of,a,person’s,body,weight,,yet,it,consumes,roughly,20,percent,of,the,body’s,energy,when,at,rest1.,Allysian’s,Mastermind,provides,the,most,advanced,nutrition,for,the,human,brain,,keeping,one,of,the,most,valuable,organs,of,the,body,at,optimal,levels.,,

Natural!Aging!!According,to,the,US,Department,of,Health,and,Human,Services,,changes,in,brain,occur,with,natural,aging.,Certain,parts,of,the,brain,shrink,,especially,the,prefrontal,cortex,(an,area,at,the,front,of,the,frontal,lobe),and,the,hippocampus.,Both,areas,are,important,to,learning,,memory,,planning,,and,other,complex,mental,activities.,Protecting,the,brain,is,just,as,important,for,young,adults,as,it,is,for,the,elderly2.,Common,neurodegenerative,diseases,such,as,Alzheimer’s,and,other,forms,of,dementia,have,been,seen,to,develop,decades,before,symptoms,are,visible.,Specific,ingredients,selected,for,the,Mastermind,Matrix,(a,precise,ratio,of,adaptogenic,botanicals),have,been,clinically,proven,to,counter,several,effects,of,natural,cognitive,decline.,,!Mastermind!Matrix!The,Mastermind,Matrix,is,a,proprietary,blend,of,four,(4),Earth>grown,ingredients,that,Allysian’s,formulation,team,has,carefully,selected,to,be,a,key,component,in,Allysian’s,core,products.,,,

1) CANPHY®!Gingko,Biloba,2) CANPHY®!Rhodiola,Rosea,3) CANPHY®!Panax,Ginseng,4) KSM>66®,Ashwagandha,

,CANPHY!CANPHY®!ingredients,are,specially,produced,by,the,Canadian,Phytopharmaceuticals,Corporation,(CPC).,These,ingredients,are,CPC’s,premium,quality,botanical,extracts,that,are,scientifically,tested,for,efficacy,and,benefits.,,!



KSM=66!KSM>66®,is,an,ashwagandha,extract,made,by,Ixoreal,Biomed,,created,through,a,process,that,took,14,years,of,R&D,to,develop,and,refine.,KSM>66®,is,the,highest>concentration,extract,on,the,world,market,today,that,is,drawn,using,only,the,roots,of,the,ashwagandha,plant.,It,is,produced,using,the,first>of>its>kind,extraction,process3.,,,KSM>66,was,chosen,as,the,recipient,of,Frost,&,Sullivan,2014,"Product,Innovation,in,Botanicals",award,“Best,Botanical,Ingredient”,award,for,2013,at,Natural,Products,Expo,West,and,“Innovative,Ingredient,of,the,Year”,award,for,2012,at,Panacea.,,Gingko!Biloba,,Gingko,Biloba,is,an,ingredient,found,in,the,Mastermind,Matrix,,and,in,a,twenty>four,(24),week,long,Grade>A,,randomized,,double>blind,,and,placebo,controlled,study,,a,group,of,elderly,subjects,with,memory,and/or,concentration,complaints,observed.,They,were,provided,a,high>dose,(HL),,low>dose,(DL),,and,placebo,(PL),amount,of,Gingko,biloba.,The,endpoints,measured,were,the,Expanded,Mental,Control,Test,(EMCT),measuring,attention,and,concentration,,Benton,Test,of,Visual,Retention>Revised,(measures,short,term,visual,memory),,the,Rey,Test,Part,1,(measures,short,term,memory,and,learning,curve),,Beck,Depressive,Inventory,(BDI),and,the,Rey,Test,Part,2,(measures,long,term,memory,and,recognition).,The,results,of,the,study,concluded,that,In,the,Benton,test,,increases,of,18%,,26%,and,11%,(expressed,as,percentage,of,baseline,scores),were,observed,in,the,HD,,LD,and,PL,respectively4.,,,Rhodiola!Rosea!A,Grade>A,,randomized,,placebo>controlled,study,showed,positive,results,with,the,use,of,Rhodiola,rosea,extracts.,The,endpoints,measured,were,exhaustion,,decreased,motivation,,daytime,sleepiness,,decreased,libido,,sleep,disturbances,,and,cognitive,complaints,(eg.,concentration,deficiencies,,

forgetfulness,,decreased,memory,,susceptibility,to,stress,,irritability).,The,study,results,showed,a,statistically,highly,significant,improvement,in,physical,and,cognitive,deficiencies,was,observed,in,the,overall,active,group.,,In,addition,,the,time,needed,to,complete,a,digit,connection,test,decreased,significantly,in,all,active,groups.,Global,assessment,of,efficacy,revealed,that,treatment,was,"very,good",or,"good",for,81%,of,patients,,as,reported,by,physicians,,and,for,80%,,as,reported,by,patients.,Ninety>nine,percent,of,patients,and,physicians,rated,safety,as,"good",or,"very,good.",5,,Panax!Ginseng!This,is,another,ingredient,found,the,in,Mastermind,Matrix,,and,in,a,9>month,long,Grade>A,,randomized,,double>blind,and,placebo,controlled,trial,,patients,with,age>associated,memory,impairment,(AAMI),were,studied.,The,subjects,were,given,standardized,Panax,ginseng,vitamin,complexes.,The,endpoints,being,studied,were,affective,status,and,memory,functions,,Symptom,Rating,Test,[SRT],(depression,,anxiety,,�omatization,,inadequacy),and,the,Randt,Memory,Test,[RMT],(memory,index,[MI]).,The,results,showed,that,AAMI,subjects,taking,the,Panax,ginseng,differ,from,controls,in,part,by,improved,scores,on,objective,cognitive,tests,,but,even,more,so,by,modifications,of,the,correlations,among,indexes,of,psychological,well>being,and,quality,of,life6.,,Ashwagandha!KSM>66,Ashwagandha,has,been,clinically,proven,to:,,

• Reduce,stress,and,anxiety,,• Enhance,memory,and,cognition,• Increase,endurance,and,strength,,• Improve,sexual,function,and,

testosterone,levels,in,men,,KSM>66,is,the,highest,concentration,full>spectrum,extract,on,the,market,today,,retaining,all,the,natural,constituents,of,the,herb,in,the,



original,balance.,It,is,also,the,ashwagandha,extract,with,the,most,extensive,set,of,research,studies,and,clinical,trials.,This,specific,brand,of,ashwagandha,is,also,the,only,major,ashwagandha,extract,in,the,world,that,is,100%,certified,organic.,KSM>66,is,GRAS,affirmed,,Kosher,,Halal,,non>GMO,certified,,vegetarian,and,gluten,free,and,safe,and,shelf>stable.3,

,,Memory!In!General!,Memory,is,an,important,core,cognitive,process,,which,involves,acquiring,,storing,and,remembering,of,environmental,information.,Memory,can,be,classified,as,short>term,memory,or,long>term,memory,,two,different,ways,we,store,information.,Short>term,memory,holds,a,small,amount,of,information,that,we,need,temporarily,,like,a,shopping,list,,whereas,the,long>term,memory,stores,memories,for,a,long,time,,like,where,we,attended,high,school.,Improving,memory,can,prevent,us,from,the,annoyance,of,forgetting,things,,such,as,where,we,left,our,car,keys,,or,where,we,put,our,reading,glasses.,The,ingredients,in,this,product,at,the,current,dose,level,have,been,shown,in,five,(5),Grade>A,studies,of,Bacopa,,four,(4),Grade>A,studies,of,Ginkgo,biloba,,one,(1),Grade>A,study,of,Rhodiola,rosea,,one,(1),Grade>A,study,of,Panax,ginseng,,one,(1),Grade>A,study,of,Astaxanthin,,and,one,(1),Grade>A,study,of,Guarana,to,be,effective,in,improving,memory,in,general,including,acquisition,and,retention,of,memory,,short>term,and,long>term,memory,,logical,memory,and,delayed,word,recall,memory.,!,In,a,2012,Grade>A,,randomized,,double>blind,,and,placebo,controlled,study,of,healthy,elderly,subjects,,standardized,Bacopa,extracts,used,by,subjects,over,the,course,of,3,months,showed,improvements,in,working,memory,,and,exhibited,suppressed,plasma,acetylcholine,activity.,,Hence,,Bacopa,may,improve,attention,,cognitive,processing,,and,working,memory,though,cholinergic,system7.,,

Working!Memory!Working,memory,entails,a,short>term,use,of,memory,and,attention.,It,is,a,set,of,skills,that,help,us,keep,information,in,mind,while,using,that,information,to,perform,a,task.,One,example,is,doing,math,calculations,where,you,have,to,hold,onto,the,numbers,in,your,head,while,working,with,them.,The,ingredients,in,this,product,at,the,current,dose,level,have,been,shown,in,two,(2),Grade>,A,studies,of,Ginkgo,biloba,,two,(2),Grade>A,studies,of,Bacopa,,one,(1),Grade>A,study,of,Panax,ginseng,,one,(1),Grade>A,study,of,Ashwagandha,to,be,effective,in,improving,working,memory.,,

The,following,are,results,from,the,interim,clinical,trials,on,the,Mastermind,product:,,



For,more,details,on,the,independent,clinical,trial,please,refer,to,www.allysian.com.,,Reaction!Time!Reaction,time,is,the,time,interval,from,the,application,of,a,stimulus,to,the,appearance,of,an,appropriate,voluntary,response,by,the,subject.,It,entails,processing,of,a,stimulus,,decision>making,,and,response,programming,(which,is,the,initiation,of,the,reaction).,It,is,of,great,practical,importance,for,day>to>day,life,for,activities,such,as,driving,(e.g.,,a,slow,reaction,time,while,driving,may,result,in,a,crash).,The,ingredients,in,this,product,at,the,current,dose,level,have,been,shown,in,two,(2),Grade>A,studies,of,ginkgo,biloba,,two,(2),Grade>A,studies,of,ashwagandha,,one,(1),Grade>A,study,of,Rhodiola,rosea,,one,(1),Grade>A,study,of,Panax,ginseng,,one,(1),Grade>A,study,of,Phosphatidylserine,,one,(1),Grade>A,study,of,Alpha,GPC,,one,(1),Grade>A,study,of,L>theanine,,and,one,(1),Grade>A,study,of,Guarana,to,be,effective,in,improving,reaction,time,including,speed,of,attention,,speed,of,memory,and,speed,of,response.,,

In,a,2013,Grade>A,study,of,recreationally,trained,individuals,,a,multi>ingredient,supplement,containing,Phosphatidylserine,(PS),,reaction,time,was,measured,following,acute,exercise,stress,was,measured.,A,significant,increase,in,performance,of,the,serial,subtraction,test,was,seen.,A,significant,increase,in,the,number,of,correct,answers,and,a,significant,decrease,in,time,to,answer,were,seen,from,pre>,to,post,workout,at,T1,and,T28.,,,Attention!and!Focus!Attention,is,the,process,of,selectively,concentrating,on,crucial,information,while,ignoring,irrelevant,information.,Within,a,typical,moment,,we,are,bombarded,with,an,overwhelming,amount,of,information,(colors,,sounds,,sensations),that,cannot,be,processed,all,at,once.,To,keep,from,being,overloaded,,we,must,selectively,choose,information,that,is,meaningful,and,discard,distractions—a,process,

that,is,called,attention.,Our,attention,skills,can,be,classified,into,three,aspects.,(1),Sustained,attention,is,our,ability,to,stay,focused,and,on>task,for,a,given,period,of,time.,(2),Selective,attention,on,the,other,hand,is,our,ability,to,quickly,sort,through,incoming,information,and,stay,focused,despite,distractions.,(3),Lastly,,our,ability,to,multi>task,is,called,divided,attention.,The,ingredients,in,this,product,at,the,current,dose,level,have,been,shown,in,four,(4),Grade>A,studies,of,L>theanine,,three,(3),Grade>A,studies,of,Bacopa,,two,(2),Grade>A,studies,of,Panax,ginseng,,one,(1),Grade>A,study,of,Phosphatidylserine,,one,(1),Grade>A,study,of,Alpha,GPC,,one,(1),Grade>A,study,of,Rhodiola,rosea,,and,one,(1),Grade>A,study,of,Guarana,to,be,effective,in,improving,attention,and,subjective,feelings,of,focus,as,well,as,improving,concentration,and,reducing,susceptibility,to,distracting,information.,,

!,Allysian’s,partnership,with,CogniFit,will,allow,Mastermind,users,to,participate,in,a,brain,fitness,program,where,users,are,able,to,not,only,nourish,their,brain,,but,also,train,it,to,increase,focus,and,divided,attention,amongst,other,cognitive,skills.,,,,,!



Alertness!Alertness,is,the,state,of,active,attention,,which,allows,feelings,of,being,awake,,vigilant,and,aware.,It,involves,a,rapid,response,to,an,expected,stimulus,,making,us,quick,to,perceive,and,act.,When,we,feel,sleepy,,there,is,a,decline,in,alertness,,which,may,lead,to,car,accidents.,The,ingredients,in,this,product,at,the,current,dose,level,have,been,shown,in,one,(1),Grade>A,study,of,Phosphatidylserine,,one,(1),Grade>A,study,of,Alpha,GPC,,one,(1),Grade>A,study,of,L>theanine,,and,one,(1),Grade>A,study,of,Guarana,to,be,effective,in,improving,subjective,feelings,of,alertness.,

Learning!and!Comprehension!Learning,is,the,acquisition,of,knowledge,or,skills,through,experience,or,study.,Enhanced,learning,is,highly,beneficial,to,students,and,to,those,trying,to,develop,new,skills,in,everyday,life.,The,ingredients,in,this,product,at,the,current,dose,level,have,been,shown,in,four,(4),Grade>A,studies,of,Bacopa,to,be,effective,in,improving,learning,and,comprehension.,,

Mental!Fatigue!Mental,fatigue,results,in,a,temporary,inability,to,perform,at,optimal,cognitive,performance,as,a,result,of,mental,over>activity.,This,often,happens,when,we,continually,exert,mental,effort,and,attention,on,a,particular,task.,After,a,long,morning,at,work,,for,example,,we,often,experience,mental,fatigue,which,makes,easy,tasks,in,the,afternoon,seem,more,complicated,,and,often,results,in,mistakes.,Mental,fatigue,can,also,be,experienced,when,we,are,physically,exhausted,,such,as,at,times,when,we,must,study,and,work,late,at,night,,which,makes,processing,of,information,difficult.,The,ingredients,in,this,product,at,the,current,dose,level,have,been,shown,in,two,(2),Grade>A,studies,of,Panax,ginseng,and,one,(1),Grade>A,study,of,Rhodiola,rosea,to,be,effective,in,decreasing,subjective,feelings,of,mental,fatigue.,!

In,a,randomized,,double>blind,,placebo,controlled,study,of,students,during,a,stressful,

examination,period,the,most,significant,improvement,in,the,use,of,the,Rhodiola,SHR>5,group,was,seen,in,physical,fitness,,mental,fatigue,and,neuro>motoric,tests9.,,,Mood!Moods,are,feelings,that,tend,to,be,less,intense,than,emotions,,cognitive,in,nature,,and,involve,two,main,characteristics,of,how,we,experience,emotions:,positive,affect,and,negative,affect.,Positive,affect,entail,positive,emotions,of,excitement,,self>assurance,,and,cheerfulness,while,the,negative,affect,dimension,consist,of,nervousness,,stress,,and,anxiety.,Our,mood,greatly,affects,the,way,our,body,feels,and,function,as,well,as,how,we,interact,socially,and,overcome,problems.,The,ingredients,in,this,product,at,the,current,dose,level,have,been,shown,in,one,(1),Grade>A,study,of,Panax,ginseng,,one,(1),Grade>A,study,of,Vinpocetine,,one,(1),Grade>A,study,of,Sage,,and,one,(1),Grade>A,study,of,Guarana,to,be,effective,in,improving,mood.,!

Anxiety!!Anxiety,is,the,apprehension,of,danger,or,something,unpleasant,that,makes,us,feel,fear,,uneasiness,and,worry.,Anxiety,continually,gives,us,a,feeling,of,stress,,even,when,the,stressor,is,gone.,Anxiety,causes,symptoms,of,rapid,heartbeat,and,breathing,,sweating,,nausea,,upset,stomach,,tight,and,painful,chest,,feeling,dizzy,,and,numbness,,all,of,which,can,contribute,to,further,feelings,of,anxiety.,The,ingredients,in,this,product,at,the,current,dose,level,have,been,shown,in,two,(2),Grade>A,studies,of,L>theanine,,two,(2),Grade>A,studies,of,Bacopa,,one,(1),Grade>A,study,of,Rhodiola,rosea,,one,(1),Grade>A,study,of,Ashwagandha,,one,(1),Grade>A,study,of,Sage,to,be,effective,in,improving,anxiety,as,well,as,tension.,!

Depression!Depression,is,a,common,mental,disorder,associated,with,depressed,mood,,loss,of,interest,or,pleasure,,reduced,vigor,and,energy,,decreased,self>confidence,,increased,



fatigability,,and,appetite,or,sleep,disturbances.,Depression,can,impact,our,ability,to,perform,our,daily,responsibilities,and,enjoy,life.,People,suffering,from,mild,depression,will,not,completely,cease,function,,but,it,can,impose,severe,difficulty,completing,regular,activities.,Severe,depression,is,likely,to,halt,all,social,,domestic,and,work>related,activities,,and,at,its,very,worst,,can,lead,to,suicide.,The,ingredients,in,this,product,at,the,current,dose,level,have,been,shown,in,one,(1),Grade>A,study,of,Rhodiola,rosea,and,one,(1),Grade>A,study,of,Bacopa,to,be,effective,in,alleviating,depression.,!

Quality!of!Life!Health>related,quality,of,life,includes,all,factors,related,to,physical,,mental,,emotional,and,social,functioning.,It,assesses,the,effect,of,our,health,status,on,quality,of,life.,It,is,also,related,to,well>,being,,which,determines,the,positive,aspects,of,our,lives,,such,as,positive,emotions,and,life,satisfaction.,The,ingredients,in,this,product,at,the,current,dose,level,have,been,shown,in,one,(1),Grade>A,study,of,,Ashwagandha,,one,(1),Grade>A,study,of,Bacopa,,and,one,(1),Grade>A,study,of,Vinpocetine,to,be,effective,in,improving,subjective,measures,quality,of,life,and,life,satisfaction.,,

Social!Functioning!!Social,functioning,is,our,interaction,with,the,environment,and,our,ability,to,fulfill,our,roles,within,social,environments,such,as,work,,social,gatherings,,and,relationships,with,partners,and,family.,It,is,also,our,ability,to,create,relationships,between,others,and,ourselves,and,

to,use,these,relationships,to,guide,us,in,our,social,behaviors.,The,ingredients,in,this,product,at,the,current,dose,level,have,been,shown,in,one,(1),Grade>A,study,of,Ginkgo,biloba,and,one,(1),Grade>A,study,of,Ashwagandha,to,be,effective,in,improving,social,functioning.,!

Mastermind!is!Easy!to!Use!As,a,dietary,supplement,,take,two,tablets,in,the,AM,and,two,tablets,in,the,PM.,Consumers,will,enjoy,the,practical,benefits,of,Mastermind:,!

• Organic.,The,ingredients,used,for,the,Allysian,Mastermind,are,organic,and,bioavailable.,

• Non=GMO.,Mastermind,is,comprised,of,botanicals,that,are,not,genetically,modified.,,

• All=Natural.,Mastermind,is,an,all>natural,supplement,containing,plant>based,ingredients.,,

• CGMP.,The,product,is,manufactured,in,a,Current,Good,Manufacturing,Practice,regulated,facility,recognized,by,the,Food,and,Drug,Administration,(FDA).,,

• Tested.,Mastermind,has,been,independently,tested,for,efficacy.,,

• Canada.,Mastermind,is,made,in,Canada,where,the,highest,manufacturing,standards,are,required,for,natural,health,products.,

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In=Text!References:!1,,Drubach,,Daniel.,The,Brain,Explained.,New,Jersey:,Prentice>Hall,,2000.,,2,,The,Changing,Brain,in,Healthy,Aging.,(2008,,September,1).,Retrieved,April,22,,2015,,from,http://www.nia.nih.gov/alzheimers/publication/part>1>basics>healthy>brain/changing>brain>healthy>aging,,3,,KSM>66,Ashwagandha,>,World's,best,Ashwagandha.,(n.d.).,Retrieved,April,22,,2015,,from,http://www.ksm66ashwagandhaa.com/,,4,,Rai,GS,,Shovlin,C,,Wesnes,KA:,A,double>blind,,placebo,controlled,study,of,Ginkgo,biloba,extract,('tanakan'),in,elderly,outpatients,with,mild,to,moderate,memory,impairment.,Curr,Med,Res,Opin,1991,,12:350>355.,,5,,Fintelmann,V,,Gruenwald,J:,Efficacy,and,tolerability,of,a,Rhodiola,rosea,extract,in,adults,with,physical,and,cognitive,deficiencies.,Adv,Ther,2007,,24:929>939.,,6,,Neri,M,,Andermarcher,E,,Pradelli,JM,,Salvioli,G:,Influence,of,a,double,blind,pharmacological,trial,on,two,domains,of,well>being,in,subjects,with,age,associated,memory,impairment.,Arch,Gerontol,Geriatr,1995,,21:241>252.,,7,,Peth>Nui,T,,Wattanathorn,J,,Muchimapura,S,,Tong>Un,T,,Piyavhatkul,N,,Rangseekajee,P,,Ingkaninan,K,,Vittaya>areekul,S:,Effects,of,12>Week,Bacopa,monnieri,Consumption,on,Attention,,Cognitive,Processing,,Working,Memory,,and,Functions,of,Both,Cholinergic,and,Monoaminergic,Systems,in,Healthy,Elderly,Volunteers.,Evidence>Based,Complementary,and,Alternative,Medicine,2012,,2012:10.,,8,,Wells,AJ,,Hoffman,JR,,Gonzalez,AM,,Stout,JR,,Fragala,MS,,Mangine,GT,,McCormack,WP,,Jajtner,AR,,Townsend,JR,,Robinson,EHt:,Phosphatidylserine,and,caffeine,attenuate,postexercise,mood,disturbance,and,perception,of,fatigue,in,humans.,Nutr,Res,2013,,33:464>472.,,9,,Spasov,AA,,Wikman,GK,,Mandrikov,VB,,Mironova,IA,,Neumoin,VV:,A,double>blind,,placebo>controlled,pilot,study,of,the,stimulating,and,adaptogenic,effect,of,Rhodiola,rosea,SHR>5,extract,on,the,fatigue,of,students,caused,by,stress,during,an,examination,period,with,a,repeated,low>dose,regimen.,Phytomedicine,2000,,7:85>89.,!

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Complied!References!

This,list,of,sources,references,clinical,studies,on,specific,ingredients,found,in,the,Allysian,Mastermind.,These,are,select,studies,of,the,400+,clinical,studies,on,the,Mastermind,ingredient,profile.,They,have,been,complied,from,various,databases.,These,studies,include,Beetroot,Extract,,Citrulline,,Agmatine,Sulfate,,Gingko,biloba,,Phosphatidylserine,,Alpha,GPC,,Coleus,forskohlii,,Artichoke,Extract,,L>theanine,,Rhodiola,,Panax,ginseng,,Ashwaganda,root,,Astaxanthin,,Bacopa,,Vinpocetine,,Fisetin,Flavanoid,,Sage,oil,extract,,and,Guarana,extract.,,,Any,claims,made,from,these,sources,,and,from,any,Allysian,Sciences,material(s),have,not,been,reviewed,by,the,Food,and,Drug,Administration,are,for,informational,purposes,only.,This!specific!compilation!is!proprietary!information!belonging!to!Allysian!Sciences!and!not!for!public!use.,Legal,counsel,is,strongly,advised,prior,to,any,reference,to,this,document,for,marketing,materials,or,product,labels.,,,References:!,Presley,TD,,Morgan,AR,,Bechtold,E,,Clodfelter,W,,Dove,RW,,Jennings,JM,,Kraft,RA,,King,SB,,Laurienti,PJ,,Rejeski,WJ,,et,al:,Acute,effect,of,a,high,nitrate,diet,on,brain,perfusion,in,older,adults.,Nitric,Oxide,2011,,24:34>42.,,Kelly,J,,Fulford,J,,Vanhatalo,A,,Blackwell,JR,,French,O,,Bailey,SJ,,Gilchrist,M,,Winyard,PG,,Jones,AM:,Effects,of,short>term,dietary,nitrate,supplementation,on,blood,pressure,,O2,uptake,kinetics,,and,muscle,and,cognitive,function,in,older,adults.,Am,J,Physiol,Regul,Integr,Comp,,,Physiol,2013,,304:R73>83.,Gilchrist,M,,Winyard,PG,,Fulford,J,,Anning,C,,Shore,AC,,Benjamin,N:,Dietary,nitrate,supplementation,improves,reaction,time,in,type,2,diabetes:,5development,and,application,of,a,novel,nitrate>depleted,beetroot,juice,placebo.,Nitric,Oxide,2014,,40:67>74.,,Thompson,KG,,Turner,L,,Prichard,J,,Dodd,F,,Kennedy,DO,,Haskell,C,,Blackwell,JR,,Jones,AM:,,Influence,of,dietary,nitrate,supplementation,on,physiological,and,cognitive,responses,to,incremental,cycle,exercise.,Respir,Physiol,Neurobiol,2014,,193:11>20.,,Oknin,V,,Fedotova,AV,,Vein,AM:,[Use,of,citrulline,malate,(stimol),in,patients,with,autonomic,dystonia,associated,with,arterial,hypotension].,Zh,Nevrol,Psikhiatr,Im,S,S,Korsakova,1999,,99:30>33.,,Fedorova,VI:,[Autonomic,disorders,in,persons,with,asthenic,syndrome,and,their,correction,with,citrulline,malate].,Zh,Nevrol,Psikhiatr,Im,S,S,Korsakova,2000,,100:32>36.,,Perez>Guisado,J,,Jakeman,PM:,Citrulline,malate,enhances,athletic,anaerobic,performance,and,relieves,muscle,soreness.,J,Strength,Cond,Res,2010,,24:1215>1222.,,Hickner,RC,,Tanner,CJ,,Evans,CA,,Clark,PD,,Haddock,A,,Fortune,C,,Geddis,H,,Waugh,W,,McCammon,M:,L>citrulline,reduces,time,to,exhaustion,and,insulin,response,to,a,graded,exercise,test.,Med,Sci,Sports,Exerc,2006,,38:660>666.,,Bendahan,D,,Mattei,JP,,Ghattas,B,,Confort>Gouny,S,,Le,Guern,ME,,Cozzone,PJ:,Citrulline/malate,promotes,aerobic,energy,production,in,human,exercising,muscle.,Br,J,Sports,Med,2002,,36:282>289.,,Wax,B,,Kavazis,AN,,Weldon,K,,Sperlak,J:,Effects,of,Supplemental,Citrulline,Malate,Ingestion,During,Repeated,Bouts,of,Lower>body,Exercise,in,Advanced,Weight,Lifters.,J,Strength,Cond,Res,2014.,,Keynan,O,,Mirovsky,Y,,Dekel,S,,Gilad,VH,,Gilad,GM:,Safety,and,Efficacy,of,Dietary,Agmatine,Sulfate,in,Lumbar,Disc>associated,Radiculopathy.,An,Open>label,,Dose>escalating,Study,Followed,by,a,Randomized,,Double>blind,,Placebo>controlled,Trial.,Pain,Med,2010,,11:356>368.,,Kaschel,R:,Specific,memory,effects,of,Ginkgo,biloba,extract,EGb,761,in,middle>aged,healthy,volunteers.,Phytomedicine,2011,,18:1202>1207.,Wesnes,KA,,Ward,T,,McGinty,A,,Petrini,O:,The,memory,enhancing,effects,of,a,Ginkgo,biloba/Panax,ginseng,combination,in,healthy,middle>aged,volunteers.,Psychopharmacology,(Berl),2000,,152:353>361.,,Mix,JA,,Crews,WD,,Jr.:,A,double>blind,,placebo>controlled,,randomized,trial,of,Ginkgo,biloba,extract,EGb,761,in,a,sample,of,cognitively,intact,older,adults:,neuropsychological,findings.,Hum,Psychopharmacol,2002,,17:267>277.,,Stough,C,,Clarke,J,,Lloyd,J,,Nathan,PJ:,Neuropsychological,changes,after,30>day,Ginkgo,biloba,administration,in,healthy,participants.,Int,J,Neuropsychopharmacol,2001,,4:131>134.,



,Polich,J,,Gloria,R:,Cognitive,effects,of,a,Ginkgo,biloba/vinpocetine,compound,in,normal,adults:,systematic,assessment,of,perception,,attention,and,memory.,Hum,Psychopharmacol,2001,,16:409>416.,,Kennedy,DO,,Scholey,AB,,Wesnes,KA:,The,dose>dependent,cognitive,effects,of,acute,administration,of,Ginkgo,biloba,to,healthy,young,volunteers.,Psychopharmacology,(Berl),2000,,151:416>423.,,Subhan,Z,,Hindmarch,I:,The,psychopharmacological,effects,of,Ginkgo,biloba,extract,in,normal,healthy,volunteers.,Int,J,Clin,Pharmacol,Res,1984,,4:89>93.,,Rigney,U,,Kimber,S,,Hindmarch,I:,The,effects,of,acute,doses,of,standardized,Ginkgo,biloba,extract,on,memory,and,psychomotor,performance,in,volunteers.,Phytother,Res,1999,,13:408>415.,,Scholey,AB,,Kennedy,DO:,Acute,,dose>dependent,cognitive,effects,of,Ginkgo,biloba,,Panax,ginseng,and,their,combination,in,healthy,young,volunteers:,differential,interactions,with,cognitive,demand.,Hum,Psychopharmacol,2002,,17:35>44.,,Singh,B,,Song,H,,Liu,XD,,Hardy,M,,Liu,GZ,,Vinjamury,SP,,Martirosian,CD:,Dangshen,(Codonopsis,pilosula),and,Bai,guo,(Gingko,biloba),enhance,learning,and,memory.,Altern,Ther,Health,Med,2004,,10:52>56.,,Scripnikov,A,,Khomenko,A,,Napryeyenko,O:,Effects,of,Ginkgo,biloba,extract,EGb,761,on,neuropsychiatric,symptoms,of,dementia:,findings,from,a,randomised,controlled,trial.,Wien,Med,Wochenschr,2007,,157:295>300.,,Wesnes,KA,,Faleni,RA,,Hefting,NR,,Hoogsteen,G,,Houben,JJ,,Jenkins,E,,Jonkman,JH,,Leonard,J,,Petrini,O,,van,Lier,JJ:,The,cognitive,,subjective,,and,physical,effects,of,a,ginkgo,biloba/panax,ginseng,combination,in,healthy,volunteers,with,neurasthenic,complaints.,Psychopharmacol,Bull,1997,,33:677>683.,,Hartley,DE,,Elsabagh,S,,File,SE:,Gincosan,(a,combination,of,Ginkgo,biloba,and,Panax,ginseng):,the,effects,on,mood,and,cognition,of,6,and,12,weeks',treatment,in,post>menopausal,women.,Nutr,Neurosci,2004,,7:325>333.,,Kennedy,DO,,Scholey,AB,,Wesnes,KA:,Differential,,dose,dependent,changes,in,cognitive,performance,following,acute,administration,of,a,Ginkgo,biloba/Panax,ginseng,combination,to,healthy,young,volunteers.,Nutr,Neurosci,2001,,4:399>412.,,Nathan,PJ,,Clarke,J,,Lloyd,J,,Hutchison,CW,,Downey,L,,Stough,C:,The,acute,effects,of,an,extract,of,Bacopa,monniera,(Brahmi),on,cognitive,function,in,healthy,normal,subjects.,Human,Psychopharmacology:,Clinical,and,Experimental,2001,,16:345>351.,,Le,Bars,PL,,Katz,MM,,Berman,N,,Itil,TM,,Freedman,AM,,Schatzberg,AF:,A,placebo>controlled,,double>blind,,randomized,trial,of,an,extract,of,Ginkgo,biloba,for,dementia.,North,American,EGb,Study,Group.,JAMA,1997,,278:1327>1332.,,Rai,GS,,Shovlin,C,,Wesnes,KA:,A,double>blind,,placebo,controlled,study,of,Ginkgo,biloba,extract,('tanakan'),in,elderly,outpatients,with,mild,to,moderate,memory,impairment.,Curr,Med,Res,Opin,1991,,12:350>355.,,Brautigam,MR,,Blommaert,FA,,Verleye,G,,Castermans,J,,Jansen,Steur,EN,,Kleijnen,J:,Treatment,of,age>related,memory,complaints,with,Ginkgo,biloba,extract:,a,randomized,double,blind,placebo>controlled,study.,Phytomedicine,1998,,5:425>434.,,Delwaide,PJ,,Gyselynck>Mambourg,AM,,Hurlet,A,,Ylieff,M:,Double>blind,randomized,controlled,study,of,phosphatidylserine,in,senile,demented,patients.,Acta,Neurol,Scand,1986,,73:136>140.,,Crook,TH,,Tinklenberg,J,,Yesavage,J,,Petrie,W,,Nunzi,MG,,Massari,DC:,Effects,of,phosphatidylserine,in,age>associated,memory,impairment.,Neurology,1991,,41:644>649.,,Cenacchi,T,,Bertoldin,T,,Farina,C,,Fiori,MG,,Crepaldi,G:,Cognitive,decline,in,the,elderly:,a,double>blind,,placebo>controlled,multicenter,study,on,efficacy,of,phosphatidylserine,administration.,Aging,(Milano),1993,,5:123>133.,,Heiss,WD,,Kessler,J,,Mielke,R,,Szelies,B,,Herholz,K:,Long>term,effects,of,phosphatidylserine,,pyritinol,,and,cognitive,training,in,Alzheimer's,disease.,A,neuropsychological,,EEG,,and,PET,investigation.,Dementia,1994,,5:88>98.,,Wells,AJ,,Hoffman,JR,,Gonzalez,AM,,Stout,JR,,Fragala,MS,,Mangine,GT,,McCormack,WP,,Jajtner,AR,,Townsend,JR,,Robinson,EHt:,Phosphatidylserine,and,caffeine,attenuate,postexercise,mood,disturbance,and,perception,of,fatigue,in,humans.,Nutr,Res,2013,,33:464>472.,,Vakhapova,V,,Cohen,T,,Richter,Y,,Herzog,Y,,Korczyn,AD:,Phosphatidylserine,containing,omega>3,fatty,acids,may,improve,memory,abilities,in,non>demented,elderly,with,memory,complaints:,a,double>blind,placebo>controlled,trial.,Dement,Geriatr,Cogn,Disord,2010,,29:467>474.,,Baumeister,J,,Barthel,T,,Geiss,KR,,Weiss,M:,Influence,of,phosphatidylserine,on,cognitive,performance,and,cortical,activity,after,induced,stress.,Nutr,Neurosci,2008,,11:103>110.,,



Schreiber,S,,Kampf>Sherf,O,,Gorfine,M,,Kelly,D,,Oppenheim,Y,,Lerer,B:,An,open,trial,of,plant>source,derived,phosphatydilserine,for,treatment,of,age>related,cognitive,decline.,Isr,J,Psychiatry,Relat,Sci,2000,,37:302>307.,Maggioni,M,,Picotti,GB,,Bondiolotti,GP,,Panerai,A,,Cenacchi,T,,Nobile,P,,Brambilla,F:,Effects,of,phosphatidylserine,therapy,in,geriatric,patients,with,depressive,disorders.,Acta,Psychiatr,Scand,1990,,81:265>270.,,Benton,D,,Donohoe,RT,,Sillance,B,,Nabb,S:,The,influence,of,phosphatidylserine,supplementation,on,mood,and,heart,rate,when,faced,with,an,acute,stressor.,Nutr,Neurosci,2001,,4:169>178.,,Canal,N,,Franceschi,M,,Alberoni,M,,Castiglioni,C,,De,Moliner,P,,Longoni,A:,Effect,of,L>alpha>glyceryl>phosphorylcholine,on,amnesia,caused,by,scopolamine.,Int,J,Clin,Pharmacol,Ther,Toxicol,1991,,29:103>107.,,De,Jesus,Moreno,Moreno,M:,Cognitive,improvement,in,mild,to,moderate,Alzheimer's,dementia,after,treatment,with,the,acetylcholine,precursor,choline,alfoscerate:,a,multicenter,,double>blind,,randomized,,placebo>controlled,trial.,Clin,Ther,2003,,25:178>193.,,Di,Perri,R,,Coppola,G,,Ambrosio,LA,,Grasso,A,,Puca,FM,,Rizzo,M:,A,multicentre,trial,to,evaluate,the,efficacy,and,tolerability,of,alpha>glycerylphosphorylcholine,versus,cytosine,diphosphocholine,in,patients,with,vascular,dementia.,J,Int,Med,Res,1991,,19:330>341.,,Hoffman,JR,,Ratamess,NA,,Gonzalez,A,,Beller,NA,,Hoffman,MW,,Olson,M,,Purpura,M,,Jager,R:,The,effects,of,acute,and,prolonged,CRAM,supplementation,on,reaction,time,and,subjective,measures,of,focus,and,alertness,in,healthy,college,students.,J,Int,Soc,Sports,Nutr,2010,,7:39.,,Barbagallo,Sangiorgi,G,,Barbagallo,M,,Giordano,M,,Meli,M,,Panzarasa,R:,alpha>Glycerophosphocholine,in,the,mental,recovery,of,cerebral,ischemic,attacks.,An,Italian,multicenter,clinical,trial.,Ann,N,Y,Acad,Sci,1994,,717:253>269.,,Baumann,G,,Felix,S,,Sattelberger,U,,Klein,G:,Cardiovascular,effects,of,forskolin,(HL,362),in,patients,with,idiopathic,congestive,cardiomyopathy>>a,comparative,study,with,dobutamine,and,sodium,nitroprusside.,J,Cardiovasc,Pharmacol,1990,,16:93>100.,,Kramer,W,,Thormann,J,,Kindler,M,,Schlepper,M:,Effects,of,forskolin,on,left,ventricular,function,in,dilated,cardiomyopathy.,Arzneimittelforschung,1987,,37:364>367.,,Henderson,S,,Magu,B,,Rasmussen,C,,Lancaster,S,,Kerksick,C,,Smith,P,,Melton,C,,Cowan,P,,Greenwood,M,,Earnest,C,,et,al:,Effects,of,coleus,forskohlii,supplementation,on,body,composition,and,hematological,profiles,in,mildly,overweight,women.,J,Int,Soc,Sports,Nutr,2005,,2:54>62.,,Bauer,K,,Dietersdorfer,F,,Sertl,K,,Kaik,B,,Kaik,G:,Pharmacodynamic,effects,of,inhaled,dry,powder,formulations,of,fenoterol,and,colforsin,in,asthma.,Clin,Pharmacol,Ther,1993,,53:76>83.,,Seamon,KB,,Padgett,W,,Daly,JW:,Forskolin:,unique,diterpene,activator,of,adenylate,cyclase,in,membranes,and,in,intact,cells.,Proc,Natl,Acad,Sci,U,S,A,1981,,78:3363>3367.,,Englisch,W,,Beckers,C,,Unkauf,M,,Ruepp,M,,Zinserling,V:,Efficacy,of,Artichoke,dry,extract,in,patients,with,hyperlipoproteinemia.,Arzneimittelforschung,2000,,50:260>265.,,Bundy,R,,Walker,AF,,Middleton,RW,,Marakis,G,,Booth,JC:,Artichoke,leaf,extract,reduces,symptoms,of,irritable,bowel,syndrome,and,improves,quality,of,life,in,otherwise,healthy,volunteers,suffering,from,concomitant,dyspepsia:,a,subset,analysis.,J,Altern,Complement,Med,2004,,10:667>669.,,Haskell,CF,,Kennedy,DO,,Milne,AL,,Wesnes,KA,,Scholey,AB:,The,effects,of,L>theanine,,caffeine,and,their,combination,on,cognition,and,mood.,Biol,Psychol,2008,,77:113>122.,,Kelly,SP,,Gomez>Ramirez,M,,Montesi,JL,,Foxe,JJ:,L>theanine,and,caffeine,in,combination,affect,human,cognition,as,evidenced,by,oscillatory,alpha>band,activity,and,attention,task,performance.,J,Nutr,2008,,138:1572S>1577S.,,Kimura,K,,Ozeki,M,,Juneja,LR,,Ohira,H:,L>Theanine,reduces,psychological,and,physiological,stress,responses.,Biol,Psychol,2007,,74:39>45.,,Giesbrecht,T,,Rycroft,JA,,Rowson,MJ,,De,Bruin,EA:,The,combination,of,L>theanine,and,caffeine,improves,cognitive,performance,and,increases,subjective,alertness.,Nutr,Neurosci,2010,,13:283>290.,,Owen,GN,,Parnell,H,,De,Bruin,EA,,Rycroft,JA:,The,combined,effects,of,L>theanine,and,caffeine,on,cognitive,performance,and,mood.,Nutr,Neurosci,2008,,11:193>198.,,Ritsner,MS,,Miodownik,C,,Ratner,Y,,Shleifer,T,,Mar,M,,Pintov,L,,Lerner,V:,L>theanine,relieves,positive,,activation,,and,anxiety,symptoms,in,patients,with,schizophrenia,and,schizoaffective,disorder:,an,8>week,,randomized,,double>blind,,placebo>controlled,,2>center,study.,J,Clin,Psychiatry,2011,,72:34>42.,,Park,SK,,Jung,IC,,Lee,WK,,Lee,YS,,Park,HK,,Go,HJ,,Kim,K,,Lim,NK,,Hong,JT,,Ly,SY,,Rho,SS:,A,combination,of,green,tea,extract,and,l>theanine,improves,memory,and,attention,in,subjects,with,mild,cognitive,impairment:,a,double>blind,placebo>controlled,study.,J,Med,Food,2011,,14:334>343.,



,Einother,SJ,,Martens,VE,,Rycroft,JA,,De,Bruin,EA:,L>theanine,and,caffeine,improve,task,switching,but,not,intersensory,attention,or,subjective,alertness.,Appetite,2010,,54:406>409.,,Gomez>Ramirez,M,,Kelly,SP,,Montesi,JL,,Foxe,JJ:,The,effects,of,L>theanine,on,alpha>band,oscillatory,brain,activity,during,a,visuo>spatial,attention,task.,Brain,Topogr,2009,,22:44>51.,,Foxe,JJ,,Morie,KP,,Laud,PJ,,Rowson,MJ,,de,Bruin,EA,,Kelly,SP:,Assessing,the,effects,of,caffeine,and,theanine,on,the,maintenance,of,vigilance,during,a,sustained,attention,task.,Neuropharmacology,2012,,62:2320>2327.,,Lu,K,,Gray,MA,,Oliver,C,,Liley,DT,,Harrison,BJ,,Bartholomeusz,CF,,Phan,KL,,Nathan,PJ:,The,acute,effects,of,L>theanine,in,comparison,with,alprazolam,on,anticipatory,anxiety,in,humans.,Hum,Psychopharmacol,2004,,19:457>465.,,Yoto,A,,Motoki,M,,Murao,S,,Yokogoshi,H:,Effects,of,L>theanine,or,caffeine,intake,on,changes,in,blood,pressure,under,physical,and,psychological,stresses.,J,Physiol,Anthropol,2012,,31:28.,,Aslanyan,G,,Amroyan,E,,Gabrielyan,E,,Nylander,M,,Wikman,G,,Panossian,A:,Double>blind,,placebo>controlled,,randomised,study,of,single,dose,effects,of,ADAPT>232,on,cognitive,functions.,Phytomedicine,2010,,17:494>499.,,Bystritsky,A,,Kerwin,L,,Feusner,JD:,A,pilot,study,of,Rhodiola,rosea,(Rhodax),for,generalized,anxiety,disorder,(GAD).,J,Altern,Complement,Med,2008,,14:175>180.,,Darbinyan,V,,Aslanyan,G,,Amroyan,E,,Gabrielyan,E,,Malmstrom,C,,Panossian,A:,Clinical,trial,of,Rhodiola,rosea,L.,extract,SHR>5,in,the,treatment,of,mild,to,moderate,depression.,Nord,J,Psychiatry,2007,,61:343>348.,,Spasov,AA,,Wikman,GK,,Mandrikov,VB,,Mironova,IA,,Neumoin,VV:,A,double>blind,,placebo>controlled,pilot,study,of,the,stimulating,and,adaptogenic,effect,of,Rhodiola,rosea,SHR>5,extract,on,the,fatigue,of,students,caused,by,stress,during,an,examination,period,with,a,repeated,low>dose,regimen.,Phytomedicine,2000,,7:85>89.,,Fintelmann,V,,Gruenwald,J:,Efficacy,and,tolerability,of,a,Rhodiola,rosea,extract,in,adults,with,physical,and,cognitive,deficiencies.,Adv,Ther,2007,,24:929>939.,,Darbinyan,V,,Kteyan,A,,Panossian,A,,Gabrielian,E,,Wikman,G,,Wagner,H:,Rhodiola,rosea,in,stress,induced,fatigue>>a,double,blind,cross>over,study,of,a,standardized,extract,SHR>5,with,a,repeated,low>dose,regimen,on,the,mental,performance,of,healthy,physicians,during,night,duty.,,Phytomedicine,2000,,7:365>371.,,Noreen,EE,,Buckley,JG,,Lewis,SL,,Brandauer,J,,Stuempfle,KJ:,The,effects,of,an,acute,dose,of,Rhodiola,rosea,on,endurance,exercise,performance.,J,Strength,Cond,Res,2013,,27:839>847.,,Wesnes,KA,,Faleni,RA,,Hefting,NR,,Hoogsteen,G,,Houben,JJ,,Jenkins,E,,Jonkman,JH,,Leonard,J,,Petrini,O,,van,Lier,JJ:,The,cognitive,,subjective,,and,physical,effects,of,a,ginkgo,biloba/panax,ginseng,combination,in,healthy,volunteers,with,neurasthenic,complaints.,Psychopharmacol,Bull,1997,,33:677>683.,,Kennedy,DO,,Haskell,CF,,Wesnes,KA,,Scholey,AB:,Improved,cognitive,performance,in,human,volunteers,following,administration,of,guarana,(Paullinia,cupana),extract:,comparison,and,interaction,with,Panax,ginseng.,Pharmacol,Biochem,Behav,2004,,79:401>411.,,Hartley,DE,,Elsabagh,S,,File,SE:,Gincosan,(a,combination,of,Ginkgo,biloba,and,Panax,ginseng):,the,effects,on,mood,and,cognition,of,6,and,12,weeks',treatment,in,post>menopausal,women.,Nutr,Neurosci,2004,,7:325>333.,,Kennedy,DO,,Scholey,AB,,Wesnes,KA:,Differential,,dose,dependent,changes,in,cognitive,performance,following,acute,administration,of,a,Ginkgo,biloba/Panax,ginseng,combination,to,healthy,young,volunteers.,Nutr,Neurosci,2001,,4:399>412.,,Lee,ST,,Chu,K,,Sim,JY,,Heo,JH,,Kim,M:,Panax,ginseng,enhances,cognitive,performance,in,Alzheimer,disease.,Alzheimer,Dis,Assoc,Disord,2008,,22:222>226.,,Scholey,AB,,Kennedy,DO:,Acute,,dose>dependent,cognitive,effects,of,Ginkgo,biloba,,Panax,ginseng,and,their,combination,in,healthy,young,volunteers:,differential,interactions,with,cognitive,demand.,Hum,Psychopharmacol,2002,,17:35>44.,,Wesnes,KA,,Ward,T,,McGinty,A,,Petrini,O:,The,memory,enhancing,effects,of,a,Ginkgo,biloba/Panax,ginseng,combination,in,healthy,middle>aged,volunteers.,Psychopharmacology,(Berl),2000,,152:353>361.,,Reay,JL,,Scholey,AB,,Kennedy,DO:,Panax,ginseng,(G115),improves,aspects,of,working,memory,performance,and,subjective,ratings,of,calmness,in,healthy,young,adults.,Hum,Psychopharmacol,2010,,25:462>471.,,Neri,M,,Andermarcher,E,,Pradelli,JM,,Salvioli,G:,Influence,of,a,double,blind,pharmacological,trial,on,two,domains,of,well>being,in,subjects,with,age,associated,memory,impairment.,Arch,Gerontol,Geriatr,1995,,21:241>252.,



Reay,JL,,Kennedy,DO,,Scholey,AB:,Single,doses,of,Panax,ginseng,(G115),reduce,blood,glucose,levels,and,improve,cognitive,performance,during,sustained,mental,activity.,J,Psychopharmacol,2005,,19:357>365.,,Reay,JL,,Kennedy,DO,,Scholey,AB:,Effects,of,Panax,ginseng,,consumed,with,and,without,glucose,,on,blood,glucose,levels,and,cognitive,performance,during,sustained,'mentally,demanding',tasks.,J,Psychopharmacol,2006,,20:771>781.,,Heo,JH,,Lee,ST,,Chu,K,,Oh,MJ,,Park,HJ,,Shim,JY,,Kim,M:,An,open>label,trial,of,Korean,red,ginseng,as,an,adjuvant,treatment,for,cognitive,impairment,in,patients,with,Alzheimer's,disease.,Eur,J,Neurol,2008,,15:865>868.,,Sørensen,H,,Sonneb,,J.:,A,double>masked,study,of,the,effects,of,ginseng,on,cognitive,functions.,Current,Therapeutic,Research,1996,,57:959>968.,,Katz,M,,Levine,AA,,Kol>Degani,H,,Kav>Venaki,L:,A,compound,herbal,preparation,(CHP),in,the,treatment,of,children,with,ADHD:,a,randomized,controlled,trial.,J,Atten,Disord,2010,,14:281>291.,,Cooley,K,,Szczurko,O,,Perri,D,,Mills,EJ,,Bernhardt,B,,Zhou,Q,,Seely,D:,Naturopathic,care,for,anxiety:,a,randomized,controlled,trial,ISRCTN78958974.,PLoS,One,2009,,4:e6628.,,Chengappa,KN,,Bowie,CR,,Schlicht,PJ,,Fleet,D,,Brar,JS,,Jindal,R:,Randomized,placebo>controlled,adjunctive,study,of,an,extract,of,withania,somnifera,for,cognitive,dysfunction,in,bipolar,disorder.,J,Clin,Psychiatry,2013,,74:1076>1083.,,Pingali,U,,Pilli,R,,Fatima,N:,Effect,of,standardized,aqueous,extract,of,Withania,somnifera,on,tests,of,cognitive,and,psychomotor,performance,in,healthy,human,participants.,Pharmacognosy,Res,2014,,6:12>18.,,Chandrasekhar,K,,Kapoor,J,,Anishetty,S:,A,prospective,,randomized,double>blind,,placebo>controlled,study,of,safety,and,efficacy,of,a,high>concentration,full>spectrum,extract,of,ashwagandha,root,in,reducing,stress,and,anxiety,in,adults.,Indian,J,Psychol,Med,2012,,34:255>262.,,Raut,AA,,Rege,NN,,Tadvi,FM,,Solanki,PV,,Kene,KR,,Shirolkar,SG,,Pandey,SN,,Vaidya,RA,,Vaidya,AB:,Exploratory,study,to,evaluate,tolerability,,safety,,and,activity,of,Ashwagandha,(Withania,somnifera),in,healthy,volunteers.,J,Ayurveda,Integr,Med,2012,,3:111>114.,,Shreevathsa,M,,Ravishankar,B,,Dwivedi,R:,Anti,depressant,activity,of,Mamsyadi,Kwatha:,An,Ayurvedic,compound,formulation.,Ayu,2013,,34:113>117.,,Bhattarai,JP,,Park,SJ,,Han,SK:,Potentiation,of,NMDA,receptors,by,Withania,somnifera,on,hippocampal,CA1,pyramidal,neurons.,Am,J,Chin,Med,2013,,41:503>513.,,Maity,T,,Adhikari,A,,Bhattacharya,K,,Biswas,S,,Debnath,PK,,Maharana,CS:,A,study,on,evalution,of,antidepressant,effect,of,imipramine,adjunct,with,Aswagandha,and,Bramhi.,Nepal,Med,Coll,J,2011,,13:250>253.,,Katagiri,M,,Satoh,A,,Tsuji,S,,Shirasawa,T:,Effects,of,astaxanthin>rich,Haematococcus,pluvialis,extract,on,cognitive,function:,a,randomised,,double>blind,,placebo>controlled,study.,J,Clin,Biochem,Nutr,2012,,51:102>107.,,Zanotta,D,,Puricelli,S,,Bonoldi,G:,Cognitive,effects,of,a,dietary,supplement,made,from,extract,of,Bacopa,monnieri,,astaxanthin,,phosphatidylserine,,and,vitamin,E,in,subjects,with,mild,cognitive,impairment:,a,noncomparative,,exploratory,clinical,study.,Neuropsychiatr,Dis,Treat,2014,,10:225>230.,,Kidd,P:,Astaxanthin,,cell,membrane,nutrient,with,diverse,clinical,benefits,and,anti>aging,potential.,Altern,Med,Rev,2011,,16:355>364.,,Satoh,A,,Tsuji,S,,Okada,Y,,Murakami,N,,Urami,M,,Nakagawa,K,,Ishikura,M,,Katagiri,M,,Koga,Y,,Shirasawa,T:,Preliminary,Clinical,Evaluation,of,Toxicity,and,Efficacy,of,A,New,Astaxanthin>rich,Haematococcus,pluvialis,Extract.,J,Clin,Biochem,Nutr,2009,,44:280>284.,,Hussein,G,,Sankawa,U,,Goto,H,,Matsumoto,K,,Watanabe,H:,Astaxanthin,,a,Carotenoid,with,Potential,in,Human,Health,and,Nutrition�.,Journal,of,Natural,Products,2005,,69:443>449.,,Yuan,J>P,,Peng,J,,Yin,K,,Wang,J>H:,Potential,health>promoting,effects,of,astaxanthin:,A,high>value,carotenoid,mostly,from,microalgae.,Molecular,Nutrition,&,Food,Research,2011,,55:150>165.,,Nishioka,Y,,Oyagi,A,,Tsuruma,K,,Shimazawa,M,,Ishibashi,T,,Hara,H:,The,antianxiety>like,effect,of,astaxanthin,extracted,from,Paracoccus,carotinifaciens.,BioFactors,2011,,37:25>30.,,Chan,K>c,,Mong,M>c,,Yin,M>c:,Antioxidative,and,Anti>Inflammatory,Neuroprotective,Effects,of,Astaxanthin,and,Canthaxanthin,in,Nerve,Growth,Factor,Differentiated,PC12,Cells.,Journal,of,Food,Science,2009,,74:H225>H231.,,Wu,W,,Wang,X,,Xiang,Q,,Meng,X,,Peng,Y,,Du,N,,Liu,Z,,Sun,Q,,Wang,C,,Liu,X:,Astaxanthin,alleviates,brain,aging,in,rats,by,attenuating,oxidative,stress,and,increasing,BDNF,levels.,Food,&,Function,2014,,5:158>166.,,



Stough,C,,Lloyd,J,,Clarke,J,,Downey,LA,,Hutchison,CW,,Rodgers,T,,Nathan,PJ:,The,chronic,effects,of,an,extract,of,Bacopa,monniera,(Brahmi),on,cognitive,function,in,healthy,human,subjects.,Psychopharmacology,(Berl),2001,,156:481>484.,,Morgan,A,,Stevens,J:,Does,Bacopa,monnieri,improve,memory,performance,in,older,persons?,Results,of,a,randomized,,placebo>controlled,,double>blind,trial.,J,Altern,Complement,Med,2010,,16:753>759.,,Calabrese,C,,Gregory,WL,,Leo,M,,Kraemer,D,,Bone,K,,Oken,B:,Effects,of,a,Standardized,Bacopa,monnieri,Extract,on,Cognitive,Performance,,Anxiety,,and,Depression,in,the,Elderly:,A,Randomized,,Double>Blind,,Placebo>Controlled,Trial.,The,Journal,of,Alternative,and,Complementary,Medicine,2008,,14:707>713.,,Stough,C,,Downey,LA,,Lloyd,J,,Silber,B,,Redman,S,,Hutchison,C,,Wesnes,K,,Nathan,PJ:,Examining,the,nootropic,effects,of,a,special,extract,of,Bacopa,monniera,on,human,cognitive,functioning:,90,day,double>blind,placebo>controlled,randomized,trial.,Phytotherapy,Research,2008,,22:1629>1634.,,Nathan,PJ,,Clarke,J,,Lloyd,J,,Hutchison,CW,,Downey,L,,Stough,C:,The,acute,effects,of,an,extract,of,Bacopa,monniera,(Brahmi),on,cognitive,function,in,healthy,normal,subjects.,Human,Psychopharmacology:,Clinical,and,Experimental,2001,,16:345>351.,,Raghav,S,,Singh,H,,Dalal,PK,,Srivastava,JS,,Asthana,OP:,Randomized,controlled,trial,of,standardized,Bacopa,monniera,extract,in,age>associated,memory,impairment.,Indian,J,Psychiatry,2006,,48:238>242.,,Nathan,PJ,,Tanner,S,,Lloyd,J,,Harrison,B,,Curran,L,,Oliver,C,,Stough,C:,Effects,of,a,combined,extract,of,Ginkgo,biloba,and,Bacopa,monniera,on,cognitive,function,in,healthy,humans.,Human,Psychopharmacology:,Clinical,and,Experimental,2004,,19:91>96.,,Roodenrys,S,,Booth,D,,Bulzomi,S,,Phipps,A,,Micallef,C,,Smoker,J:,Chronic,Effects,of,Brahmi,(Bacopa,monnieri),on,Human,Memory.,Neuropsychopharmacology,2002,,27:279>281.,,Peth>Nui,T,,Wattanathorn,J,,Muchimapura,S,,Tong>Un,T,,Piyavhatkul,N,,Rangseekajee,P,,Ingkaninan,K,,Vittaya>areekul,S:,Effects,of,12>Week,Bacopa,monnieri,Consumption,on,Attention,,Cognitive,Processing,,Working,Memory,,and,Functions,of,Both,Cholinergic,and,Monoaminergic,Systems,in,Healthy,Elderly,Volunteers.,Evidence>Based,Complementary,and,Alternative,Medicine,2012,,2012:10.,,Downey,LA,,Kean,J,,Nemeh,F,,Lau,A,,Poll,A,,Gregory,R,,Murray,M,,Rourke,J,,Patak,B,,Pase,MP,,et,al:,An,Acute,,Double>Blind,,Placebo>Controlled,Crossover,Study,of,320 ,mg,and,640 mg,doses,of,a,Special,Extract,of,Bacopa,monnieri,(CDRI,08),on,Sustained,Cognitive,Performance.,Phytotherapy,Research,2013,,27:1407>1413.,,Benson,S,,Downey,LA,,Stough,C,,Wetherell,M,,Zangara,A,,Scholey,A:,An,acute,,double>blind,,placebo>controlled,cross>over,study,of,320,mg,and,640,mg,doses,of,Bacopa,monnieri,(CDRI,08),on,multitasking,stress,reactivity,and,mood.,Phytother,Res,2014,,28:551>559.,,Goswami,S,,Saoji,A,,Kumar,N,,Thawani,V,,M.,T,,Thawani,M:,Effect,of,Bacopa,monnieri,on,Cognitive,Function,in,Alzheimer's,disease,patients.,International,journal,of,Collaborative,Research,on,Internal,Medicine,and,Public,Health,2011,,3:285>293.,,Kongkeaw,C,,Dilokthornsakul,P,,Thanarangsarit,P,,Limpeanchob,N,,Norman,Scholfield,C:,Meta>analysis,of,randomized,controlled,trials,on,cognitive,effects,of,Bacopa,monnieri,extract.,J,Ethnopharmacol,2014,,151:528>535.,,Stough,C,,Scholey,A,,Cropley,V,,Wesnes,K,,Zangara,A,,Pase,M,,Savage,K,,Nolidin,K,,Lomas,J,,Downey,L:,Examining,the,cognitive,effects,of,a,special,extract,of,Bacopa,monniera,(CDRI08:,Keenmnd):,a,review,of,ten,years,of,research,at,Swinburne,University.,J,Pharm,Pharm,Sci,2013,,16:254>258.,,Pase,MP,,Kean,J,,Sarris,J,,Neale,C,,Scholey,AB,,Stough,C:,The,Cognitive>Enhancing,Effects,of,Bacopa,monnieri:,A,Systematic,Review,of,Randomized,,Controlled,Human,Clinical,Trials.,The,Journal,of,Alternative,and,Complementary,Medicine,2012,,18:647>652.,,Ernst,E:,Herbal,remedies,for,anxiety,–,a,systematic,review,of,controlled,clinical,trials.,Phytomedicine,2006,,13:205>208.,,Sathyanarayanan,V,,Thomas,T,,Einöther,SL,,Dobriyal,R,,Joshi,MK,,Krishnamachari,S:,Brahmi,for,the,better?,New,findings,challenging,cognition,and,anti>anxiety,effects,of,Brahmi,(Bacopa,monniera),in,healthy,adults.,Psychopharmacology,2013,,227:299>306.,,Dave,UP,,Dingankar,SR,,Saxena,VS,,Joseph,JA,,Bethapudi,B,,Agarwal,A,,Kudiganti,V:,An,open>label,study,to,elucidate,the,effects,of,standardized,Bacopa,monnieri,extract,in,the,management,of,symptoms,of,attention>deficit,hyperactivity,disorder,in,children.,Adv,Mind,Body,Med,2014,,28:10>15.,,Mehta,P,,Purohit,S,,Chauhan,K:,A,Study,on,Nutrition,and,Health,Profile,of,Depressed,Adult,and,Elderly,Men,of,Baroda,City:,Impact,of,Herbal,Intervention,with,Brahmi,(Bacopa,monniera).,Indian,Journal,of,Gerontology,2010,,24:49>58.,,Sairam,K,,Dorababu,M,,Goel,RK,,Bhattacharya,SK:,Antidepressant,activity,of,standardized,extract,of,Bacopa,monniera,in,experimental,models,of,depression,in,rats.,Phytomedicine,2002,,9:207>211.,,



Vollala,VR,,Upadhya,S,,Nayak,S:,Effect,of,Bacopa,monniera,Linn.,(brahmi),extract,on,learning,and,memory,in,rats:,A,behavioral,study.,Journal,of,Veterinary,Behavior:,Clinical,Applications,and,Research,2010,,5:69>74.,,Bhattacharya,SK,,Ghosal,S:,Anxiolytic,activity,of,a,standardized,extract,of,Bacopa,monniera:,an,experimental,study.,Phytomedicine,1998,,5:77>82.,,Shen,Y>H,,Zhou,Y,,Zhang,C,,Liu,R>H,,Su,J,,Liu,X>H,,Zhang,W>D:,Antidepressant,effects,of,methanol,extract,and,fractions,of,Bacopa,monnieri.,Pharmaceutical,Biology,2009,,47:340>343.,,Uabundit,N,,Wattanathorn,J,,Mucimapura,S,,Ingkaninan,K:,Cognitive,enhancement,and,neuroprotective,effects,of,Bacopa,monnieri,in,Alzheimer's,disease,model.,Journal,of,Ethnopharmacology,2010,,127:26>31.,,Thal,LJ,,Salmon,DP,,Lasker,B,,Bower,D,,Klauber,MR:,The,safety,and,lack,of,efficacy,of,vinpocetine,in,Alzheimer's,disease.,J,Am,Geriatr,Soc,1989,,37:515>520.,,Hindmarch,I,,Fuchs,HH,,Erzigkeit,H:,Efficacy,and,tolerance,of,vinpocetine,in,ambulant,patients,suffering,from,mild,to,moderate,organic,psychosyndromes.,Int,Clin,Psychopharmacol,1991,,6:31>43.,,Balestreri,R,,Fontana,L,,Astengo,F:,A,double>blind,placebo,controlled,evaluation,of,the,safety,and,efficacy,of,vinpocetine,in,the,treatment,of,patients,with,chronic,vascular,senile,cerebral,dysfunction.,J,Am,Geriatr,Soc,1987,,35:425>430.,,Subhan,Z,,Hindmarch,I:,Psychopharmacological,effects,of,vinpocetine,in,normal,healthy,volunteers.,Eur,J,Clin,Pharmacol,1985,,28:567>571.,,Kemény,V,,Molnár,S,,Andrejkovics,M,,Makai,A,,Csiba,L:,Acute,and,Chronic,Effects,of,Vinpocetine,on,Cerebral,Hemodynamics,and,Neuropsychological,Performance,in,Multi>infarct,Patients.,The,Journal,of,Clinical,Pharmacology,2005,,45:1048>1054.,,Valikovics,A:,[Investigation,of,the,effect,of,vinpocetine,on,cerebral,blood,flow,and,cognitive,functions].,Ideggyogy,Sz,2007,,60:301>310.,,Blaha,L,,Erzigkeit,H,,Adamczyk,A,,Freytag,S,,Schaltenbrand,R:,Clinical,evidence,of,the,effectiveness,of,vinpocetine,in,the,treatment,of,organic,psychosyndrome.,Human,Psychopharmacology:,Clinical,and,Experimental,1989,,4:103>111.,,Szatmari,SZ,,Whitehouse,PJ:,Vinpocetine,for,cognitive,impairment,and,dementia.,Cochrane,Database,Syst,Rev,2003:CD003119.,Pereira,C,,Agostinho,P,,Oliveira,CR:,Vinpocetine,attenuates,the,metabolic,dysfunction,induced,by,amyloid,beta>peptides,in,PC12,cells.,Free,Radic,Res,2000,,33:497>506.,,Maher,PA:,Methods,of,using,flavonoids,to,enhance,memory.,Google,Patents;,2011.,,Currais,A,,Prior,M,,Dargusch,R,,Armando,A,,Ehren,J,,Schubert,D,,Quehenberger,O,,Maher,P:,Modulation,of,p25,and,inflammatory,pathways,by,fisetin,maintains,cognitive,function,in,Alzheimer's,disease,transgenic,mice.,Aging,Cell,2014,,13:379>390.,,Maher,P,,Akaishi,T,,Abe,K:,Flavonoid,fisetin,promotes,ERK>dependent,long>term,potentiation,and,enhances,memory.,Proceedings,of,the,National,Academy,of,Sciences,2006,,103:16568>16573.,,Maher,P,,Dargusch,R,,Bodai,L,,Gerard,P,,Purcell,J,,Marsh,JL:,ERK,Activation,by,the,Polyphenols,Fisetin,and,Resveratrol,Provides,Neuroprotection,in,Multiple,Models,of,Huntington's,Disease.,Human,Molecular,Genetics,2010.,,Maher,P:,Modulation,of,multiple,pathways,involved,in,the,maintenance,of,neuronal,function,during,aging,by,fisetin.,Genes,&,Nutrition,2009,,4:297>307.,,Zhen,L,,Zhu,J,,Zhao,X,,Huang,W,,An,Y,,Li,S,,Du,X,,Lin,M,,Wang,Q,,Xu,Y,,Pan,J:,The,antidepressant>like,effect,of,fisetin,involves,the,serotonergic,and,noradrenergic,system.,Behavioural,Brain,Research,2012,,228:359>366.,,Prakash,D,,Gopinath,K,,Sudhandiran,G:,Fisetin,Enhances,Behavioral,Performances,and,Attenuates,Reactive,Gliosis,and,Inflammation,During,Aluminum,Chloride>Induced,Neurotoxicity.,NeuroMolecular,Medicine,2013,,15:192>208.,,Zheng,LT,,Ock,J,,Kwon,B>M,,Suk,K:,Suppressive,effects,of,flavonoid,fisetin,on,lipopolysaccharide>induced,microglial,activation,and,neurotoxicity.,International,Immunopharmacology,2008,,8:484>494.,,Maher,P:,The,flavonoid,fisetin,promotes,nerve,cell,survival,from,trophic,factor,withdrawal,by,enhancement,of,proteasome,activity.,Archives,of,Biochemistry,and,Biophysics,2008,,476:139>144.,,Cho,N,,Lee,KY,,Huh,J,,Choi,JH,,Yang,H,,Jeong,EJ,,Kim,HP,,Sung,SH:,Cognitive>enhancing,effects,of,Rhus,verniciflua,bark,extract,and,its,active,flavonoids,with,neuroprotective,and,anti>inflammatory,activities.,Food,Chem,Toxicol,2013,,58:355>361.,,Kennedy,DO,,Dodd,FL,,Robertson,BC,,Okello,EJ,,Reay,JL,,Scholey,AB,,Haskell,CF:,Monoterpenoid,extract,of,sage,(Salvia,lavandulaefolia),with,cholinesterase,inhibiting,properties,improves,cognitive,performance,and,mood,in,healthy,adults.,J,Psychopharmacol,2011,,25:1088>1100.,



Scholey,AB,,Tildesley,NT,,Ballard,CG,,Wesnes,KA,,Tasker,A,,Perry,EK,,Kennedy,DO:,An,extract,of,Salvia,(sage),with,anticholinesterase,properties,improves,memory,and,attention,in,healthy,older,volunteers.,Psychopharmacology,(Berl),2008,,198:127>139.,,Kennedy,DO,,Pace,S,,Haskell,C,,Okello,EJ,,Milne,A,,Scholey,AB:,Effects,of,cholinesterase,inhibiting,sage,(Salvia,officinalis),on,mood,,anxiety,and,performance,on,a,psychological,stressor,battery.,Neuropsychopharmacology,2006,,31:845>852.,,Tildesley,NT,,Kennedy,DO,,Perry,EK,,Ballard,CG,,Savelev,S,,Wesnes,KA,,Scholey,AB:,Salvia,lavandulaefolia,(Spanish,sage),enhances,memory,in,healthy,young,volunteers.,Pharmacol,Biochem,Behav,2003,,75:669>674.,,Akhondzadeh,S,,Noroozian,M,,Mohammadi,M,,Ohadinia,S,,Jamshidi,AH,,Khani,M:,Salvia,officinalis,extract,in,the,treatment,of,patients,with,mild,to,moderate,Alzheimer's,disease:,a,double,blind,,randomized,and,placebo>controlled,trial.,Journal,of,Clinical,Pharmacy,and,Therapeutics,2003,,28:53>59.,,Tildesley,NTJ,,Kennedy,DO,,Perry,EK,,Ballard,CG,,Wesnes,KA,,Scholey,AB:,Positive,modulation,of,mood,and,cognitive,performance,following,administration,of,acute,doses,of,Salvia,lavandulaefolia,essential,oil,to,healthy,young,volunteers.,Physiology,&,Behavior,2005,,83:699>709.,,Miroddi,M,,Navarra,M,,Quattropani,MC,,Calapai,F,,Gangemi,S,,Calapai,G:,Systematic,review,of,clinical,trials,assessing,pharmacological,properties,of,Salvia,species,on,memory,,cognitive,impairment,and,Alzheimer's,disease.,CNS,Neurosci,Ther,2014,,20:485>495.,,Perry,NSL,,Bollen,C,,Perry,EK,,Ballard,C:,Salvia,for,dementia,therapy:,review,of,pharmacological,activity,and,pilot,tolerability,clinical,trial.,Pharmacology,Biochemistry,and,Behavior,2003,,75:651>659.,,Herrera>Ruiz,M,,García>Beltrán,Y,,Mora,S,,Díaz>Véliz,G,,Viana,GSB,,Tortoriello,J,,Ramírez,G:,Antidepressant,and,anxiolytic,effects,of,hydroalcoholic,extract,from,Salvia,elegans.,Journal,of,Ethnopharmacology,2006,,107:53>58.,,Haskell,CF,,Kennedy,DO,,Wesnes,KA,,Milne,AL,,Scholey,AB:,A,double>blind,,placebo>controlled,,multi>dose,evaluation,of,the,acute,behavioural,effects,of,guarana,in,humans.,J,Psychopharmacol,2007,,21:65>70.,,Kennedy,DO,,Haskell,CF,,Wesnes,KA,,Scholey,AB:,Improved,cognitive,performance,in,human,volunteers,following,administration,of,guarana,(Paullinia,cupana),extract:,comparison,and,interaction,with,Panax,ginseng.,Pharmacol,Biochem,Behav,2004,,79:401>411.,,Scholey,A,,Bauer,I,,Neale,C,,Savage,K,,Camfield,D,,White,D,,Maggini,S,,Pipingas,A,,Stough,C,,Hughes,M:,Acute,effects,of,different,multivitamin,mineral,preparations,with,and,without,Guarana,on,mood,,cognitive,performance,and,functional,brain,activation.,Nutrients,2013,,5:3589>3604.,da,Costa,Miranda,V,,Trufelli,DC,,Santos,J,,Campos,MP,,Nobuo,M,,da,Costa,Miranda,M,,Schlinder,F,,Riechelmann,R,,del,Giglio,A:,Effectiveness,of,guarana,(Paullinia,cupana),for,postradiation,fatigue,and,depression:,results,of,a,pilot,double>blind,randomized,study.,J,Altern,Complement,Med,2009,,15:431>433.,,Kennedy,DO,,Haskell,CF,,Robertson,B,,Reay,J,,Brewster>Maund,C,,Luedemann,J,,Maggini,S,,Ruf,M,,Zangara,A,,Scholey,AB:,Improved,cognitive,performance,and,mental,fatigue,following,a,multi>vitamin,and,mineral,supplement,with,added,guaraná,(Paullinia,cupana).,Appetite,2008,,50:506>513.,,Silvestrini,GI,,Marino,F,,Cosentino,M:,Effects,of,a,commercial,product,containing,guarana,on,psychological,well>being,,anxiety,and,mood:,a,single>blind,,placebo>controlled,study,in,healthy,subjects.,J,Negat,Results,Biomed,2013,,12:9.,,Bittencourt,Lda,S,,Zeidan>Chulia,F,,Yatsu,FK,,Schnorr,CE,,Moresco,KS,,Kolling,EA,,Gelain,DP,,Bassani,VL,,Moreira,JC:,Guarana,(Paullinia,cupana,Mart.),Prevents,beta>Amyloid,Aggregation,,Generation,of,Advanced,Glycation>end,Products,(AGEs),,and,Acrolein>Induced,Cytotoxicity,on,Human,Neuronal>Like,Cells.,Phytother,Res,2014,,28:1615>1624.,,,

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