Innovation and Growth in Advanced DiagnosticsCarrie Eglinton MannerSVP, Advanced Diagnostics

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SAFE HARBOR DISCLOSURE

The statements in the following presentations that are not historical facts may be forward-lookingstatements. Readers are cautioned not to place undue reliance on forward-looking statements,which speak only as of the date that they are made and which reflect management’s currentestimates, projections, expectations or beliefs and which involve risks and uncertainties that couldcause actual results and outcomes to be materially different. Risks and uncertainties that mayaffect the future results of the Company include, but are not limited to, adverse results frompending or future government investigations, lawsuits or private actions, the competitiveenvironment, changes in government regulations, changing relationships with customers, payers,suppliers or strategic partners and other factors discussed in the Company's most recently filedAnnual Report on Form 10-K and in any of the Company's subsequently filed Quarterly Reports onForm 10-Q and Current Reports on Form 8-K, including those discussed in the “Business,” “RiskFactors,” “Cautionary Factors that May Affect Future Results” and “Management’s Discussion andAnalysis of Financial Condition and Results of Operations” sections of those reports.

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20 years ago

FDA approves Herceptin for breast cancer targeted at the tumor’s genetics

This week

FDA approves Vitrakvi for a specific genetic mutation, not cancer type

How far we’ve come

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Source: US National Cancer Institute

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Leading position in significant growth market$1B+ in Advanced Diagnostics

Strong health system-hospital relationshipsProfitable growth

Better Access = Stronger Growth

NeurologyOncology Women’s Health CardioMetabolicInfectious Disease

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Differentiated strengths to generate growth

Size and scale for broad innovation

access

Medical expertise to translate science into reimbursable

services

Science and Innovation

~500 patents

~150 studies published a year

High-end technology automation

End-to-end solutions for

convenience and support

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Memphis

Cleveland

Orange County –San Juan Capistrano (SJC)

Valencia

Dallas - Lewisville

DC Metro – Chantilly, VA

Boston – Marlborough

Broad network of advanced laboratories

Esoteric Laboratory

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Strong reputation for global opportunities: Global Diagnostics Network

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Four pillars to deliver value and growth through innovation

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Partnerships & Acquisitions

Science & Innovation

Actionable | Accessible | Reimbursable

ExpertiseService

Experience

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Closing crucial gaps in product innovation

Internal R&D

Carrier Screening

Exome Sequencing-Newborn

Alzheimer’s Disease

Since late 2016 …

Partners

Liquid Biopsy

Artificial Intelligence

Digital Pathology

Consumer Genetics

Companion Diagnostics

Acquisitions

Community Cancer

Fertility

Cardio-metabolic

Tuberculosis

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Q: Am I covered?

Developing enhanced services to meet amplified expectations

A: Pre-authorization

Q: How much will it cost?

A: Out of pocket price estimation

Q: What do my results mean?

A: Genetic counseling services

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Partnering to seize market opportunities

Market development• Community Oncology

• Tuberculosis screening

• Women’s Health

Research• PROMISE – Multiple myeloma

• BFOR – Breast Cancer / BRCA

• Dementia Discovery Fund

• One Brave Idea – Heart Disease

Early stage and pharma• ~50 companion diagnostics • Q2 joint venture

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The full complement for multiple myelomaWe are delivering leading solutions across the patient journey

Diagnostic Pathways

Prescription Drug Monitoring

Full clinical menu

Digital PathologyEarly Genetic Risk Assessment Screening Trial

MyPRS Genomic Profiling

Daratumumab-specific

Immunofixation

MRD Flow Cytometry

Screening Diagnosis Prognosis Treatment Monitoring

PCP Hematologist

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Accompanying women on their healthcare journey

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Well WomanAdolescence to post-menopause

Health & Wellness – STDs Inherited Genetics (BRCA) – Consumer / At Home

Pre-conception

Carrier screening

FertilityReproSource

Post-natal / newborn

Exome sequencing

Pregnancy

Noninvasive prenatal screening

Out-of-pocket estimates

Patient-facing genetic counseling

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Health SystemsServices provide clinical value that payers reimburse

ConsumerInherited

Genetics and the basis of

Precision Health

Advanced Diagnostics delivers value across our core strategies

M&AInnovation

hospital labs can’t provide

Data / Population Health

Bioinformatics

AI-infused data

Genetics

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Key takeaways

Precision medicine and Advanced Diagnostics represent strong growth potential

We lead today, we’re profitable, and our strengths position us to win more

Expanded health plan access will build momentum to accelerate profitable growth