innovation, creativity, and...

Innovation | Creativity | Convergence

Innovation, Creativity, and Convergence are Pride of Department of Biomedical Sciences at the Graduate School of KU College of Medicine

We nurture core biomedical scientists who contribute to treatment of human diseases and improvement of health at the center of the world’s biomedical education.

Department of Biomedical Sciences at KU (affiliated with College of Medicine) has walked steadfast

along the path of biomedical science in respect for life and love for humanity. As a cradle cultivating

sophisticated biomedical scientists, and as one of the world’s best biomedical research institute that

trains leading global biomedical scientists, we are heading at the heart of the world’s biomedical science.

CONTENTS

04 Featured Research

06 Faculty & Research Units Basic Researchers

Clinical Researchers

Core Facilities

10 Curriculum

12 Scholarships

13 Admission Guide

14 Contact Information

15 Campus Map

Appendix I

17 Faculty & Laboratories

Appendix II

64 Curriculum (Full List)

Prologue 02 03

Discovery of a Novel Sensory Receptor

Neuronal sensory receptors are key contact

points to the environment, initiating

decisions for avoidance or preference.

Electrophysiology shows:

· TMC-1 is a novel ion channel.

· TMC-1 mediates high level sodium-

induced excitation.

· TMC-1 recording techniques may provide

a drug-screening platform.

Behavioral neuroscience shows:

· Nociceptor neurons express TMC-1.

· TMC-1 is necessary for nociceptive

behaviors against harmful levels of

sodium.

Chatzigeorgiou et al., 2013, Nature 494:95

Circadian Basis of Mood Regulation

Circadian molecular clockworks in

midbrain dopamine (DA) neurons:

Key regulators of mood

Impaired REV-ERBα actions

in DA neurons:

· Mania-like behaviors in mice

· HyperDAergic state:

Increased DA synthesis & release

Cooperation of REV-ERBα & NURR1:

· Circadian expression of tyrosine

hydroxylase (TH), a rate-limiting

factor of DA biosynthesis

· Competitive and rhythmic binding

onto TH promoter

Chung et al., 2014, Cell 157:858

Hematogenous Metastasis of Ovarian Cancer

ErbB3-neuregulin 1 (NRG1) axis is a

dominant pathway responsible for

hematogenous omental metastasis.

Elevated levels of ErbB3 in ovarian

cancer cells and NRG1 in the

omentum allowed for tumor cell

localization and growth in the

omentum. Depletion of ErbB3 in

ovarian cancer impaired omental

metastasis.

→ Ovarian cancer metastasis whereby

ErbB3 plays a critical role in

hematogenous dissemination of

ovarian cancer to the omentum.

Pradeep et al., 2014, Cancer Cell, 26(1):77

Featured Research01

Evolutionary Mechanism for Neuropeptide and GPCR Gene Families The vertebrate gene family

expands their members

through an evolutionary

mechanism including:

· local gene duplications

· 2 rounds (2R) of whole

genome duplication

Neuropeptides and their

G-protein-coupled receptors

coevolve through mutual

interactions

Understanding this mechanism

allows

· Identifi cation of novel

neuropeptide members

· Prediction of new peptide-

orphan receptor pairs

Hwang et al., 2013, Mol Biol Evol 30:1119

Cross-talk between Brain and Adipose Tissue Vasculature Apoptosis of endothelium in

white adipose tissue (WAT)

decreases body weight and food

intake independent of

hypothalamic leptin signaling.

Inhibition of WAT angiogenesis

rapidly improves glucose tolerance

independent of weight loss or

reduction in food intake.

Metabolomic and transcriptomic

studies suggest

· a novel role of the WAT

vasculature in glucose regulation

and lipid metabolism

· the existence of a previously

unknown player for the Brain-

WAT vasculature axis

Kim et al., 2012, Diabetes 61: 2299

Reliability and Performance of Different Stent Designs

A comparative reliability and performance study

of different stent designs: → To improve the mechanical performance of

stents

Conducting reliability performance testing

· Foreshortening, recoil, radial force and fl exibility

Finite element method(FEM) simulation

· Material properties for elasto-plastic analysis

· Coeffi cients of elasticity’s ratio was set to 13.22

Gpa

· Coeffi cients of poisson’s ratio was set to 0.30

We found that our design which was created

by a collaborative team from seven universities,

performed better than the commercial stents

across all parameter of foreshortening, recoil,

radial force, and fl exibility.

Choi et al., 2013, Arti� cial Organs 37:4

Featured Researches 04 05

Basic ResearchersProfessor Laboratory E-mail / Website

CHOI, Hyuk Lab of Biomedical Engineering [email protected] / ibr.korea.ac.kr

GEUM, Dongho Lab of Stem Cell Biology [email protected]

HAN, Hee Chul Neuroscience Research Institute [email protected]

HWANG, Jong-Ik Lab of GPCR and Signal Transduction [email protected] / gpcr.or.kr

HWANG, Sun Wook Lab of Sensory Neuroscience [email protected]

KEE, Sun-Ho Lab of Cell Biology [email protected]

KIM, Dong-Hoon Lab of Metabolic Disease [email protected]

KIM, Hyeon Soo Lab of AMPK Signal Transduction [email protected]

KIM, Hyun Lab of Molecular & Behavioral Neurobiology [email protected] / braingene.com

KIM, Tae Woo Lab of Tumor-Immune Dynamics [email protected]

KIM, Won-Ki Lab of Neuroscience [email protected]

KIM, Yang In Lab of Circadian Rhythm and Hypertension [email protected]

LEE, Eun Il Lab of Environment & Healthy Longevity [email protected]

LEE, Kyung-Mi Lab of Global Immunology Research [email protected]

MIN, Bon Hong Lab of Molecular Pharmacology [email protected]

NA, Heung Sik Lab of Sensory Abnormalities; Pain and Itch [email protected]

OH, Jun Seo Lab of Matrix Biology [email protected]

PARK, Hae Chul Lab of Neurodevelopmental Genetics [email protected]

PARK, Yongdoo Lab of Cell and Tissue Engineering [email protected] / cte.korea.ac.kr

RHYU, Im Joo Lab of Brain Structure and Neural Network [email protected]

SEONG, Jae Young Lab of GPCR and Signal Transduction [email protected] / gpcr.or.kr

SHIN, Ok Sarah Lab of Infection and Immunity [email protected]

SON, Gi Hoon Lab of Molecular Networks and Neurobiology [email protected]

SONG, Hoseok Lab of Cancer Biology [email protected]

SONG, Jin Won Lab of Molecular Virology [email protected]

SUL, Dong Geun Lab of Biomedical Proteomics [email protected]

SUN, Woong Lab of Neural Development and Stem Cell Research [email protected]

YOON, Young Wook Department of Physiology [email protected]

Faculty & Research Units02

Clinical ResearchersProfessor Laboratory E-mail / Website

CHO, Jae-Gu Department of Otorhinolaryngology-Head and Neck Surgery [email protected]

CHOE, Jae Gol Department of Nuclear Medicine [email protected]

HAM, Byung-Joo Interdisciplinary Affective Neuroscience Lab [email protected]

HONG, Soon Cheol Lab of Placenta Stem Cells [email protected]

KIM, Aeree Department of Pathology [email protected]

KIM, Byung Soo Department of Medical Oncology and Hematology [email protected]

KIM, Dong-Sik Lab of HBP Surgery & Liver Transplantation [email protected]

KIM, Hyun Koo Lab of Image-guided Cancer Surgery [email protected]

KIM, Min Ja Lab of Infection and Immunity [email protected]

KIM, Woo Joo Department of Infectious Diseases [email protected]

KIM, Yeul Hong Cancer Research Institute [email protected]

LEE, Chang Kyu Department of Lab Medicine [email protected]

LEE, Heon-Jeong Lab of the Circadian Rhythm & Mood Disorders [email protected] / kuhjnv.wix.com/circadianrhythmmood

LEE, Heung Man The Upper Airway Research Institute (TUARI) [email protected] / tuari.korea.ac.kr

LEE, Suk Lab of Medical Physics [email protected]

LIM, Chae Seung Lab of Biomedical Engineering [email protected]

LIM, Do-Sun Lab of Cardiac Regeneration [email protected]

OH, Sang Cheul Lab of Gastrointestinal Cancer Biology [email protected]

PARK, Jong Woong Hand Surgery & Reconstructive Microsurgery [email protected]

PARK, Kyong Hwa Department of Medical Oncology and Hematology [email protected]

RHA, Seung-Woon Cardiovascular Intervention and Research Institute [email protected] / www.ciri.or.kr

SEO, Jae Hong Lab of Breast Cancer Targeting Drug [email protected]

SHIN, Chol Korean Genome and Epidemiology Study (KoGES) [email protected]

SHIN, Sang-Wan Lab of Dental Research [email protected] / www.icdr.kr

SON, Sang Wook Lab of Cell Signaling and Nanomedicine [email protected]

SONG, Hae Ryong Lab of Bone Defect/Disease Fusion-Therapy Center [email protected] / www.kumcbone.or.kr

SUH, Seung-Wo Department of Orthopedic Surgery [email protected]

YOO, Hye Jin Lab of Diabetes & Atherosclerosis [email protected]

YOON, Soo-Young Lab of Diagnostic Technology Development [email protected]

※ Please see Appendix I for more detailed information on faculty members and their laboratories.

Faculty & Research U

nits 06 07

Medical Science Research Center

Main Research Facility in the KU College of Medicine The KU Medical Science Research Center (MSRC) was established to provide the up-to-date research and

educational facilities to the biomedical researchers in the KU College of Medicine for securing the research

competitiveness through this basic sciences infra.

KU-MSRC has successfully achieved its goals through the procurement of research equipment and effi cient

operation of education and training programs.→ More information is also available at our website: http://msrc.korea.ac.kr/

Key Research Facilities of the KU-MSRC Microscopy Lab: Electron Microscope (EM), Confocal Microscope, Total internal refl ection fl uorescence

microscopy (TIRF), etc

Core Facility Lab: Providing key equipments required for advanced biomedical research

Lab for radioactive isotopic materials

Core Facilities

Laboratory Animal Research Center

Our Mission The primary task of the KUMC Laboratory Animal Research Center (KLARC) is to house and breed various

animal species and strains according to the needs of the scientists working at the KU College of Medicine.

KLARC also aims to provide an effi cient research environment, where researchers can carry out both in-vivo

and ex-vivo experiments at one-stop under clean condition.→ More information is available at our website: http://klarc.korea.ac.kr

TIRF Microscope (TIRF 3) Confocal Microscope (LSM 700) MicroCT (SKYSCAN)TEM (H-7500)

Integrated & Translational Research Program

Our Mission In cooperation with KLARC, KU Integrated & Translational Research Program (KU-ITRP) aims to promote

and support productive collaborations among basic and clinical scientists in the Korea University College of

Medicine.

Supporting: This program helps clinical scientists in KU to effi ciently achieve excellence in their research by

providing molecular and cellular biological technologies.

Mentoring: The program promotes more active collaborations between basic and clinical scientists linking

their idea and expertise to expand world-class leading biomedical sciences in KU.→ More information is available at the KLARC website: http://klarc.korea.ac.kr

KU Practical Anatomy Center

The Leading Anatomy Center & Research Institute in Korea The KU Practical Anatomy Center & Research Institute (KU-PARI) has been founded in 2012 to support

anatomical/surgical education as well as related researches.

KU-PARI offers distinctive hands-on programs to students, researchers and surgeons.→ More information is also available at our website: http://pari.korea.ac.kr

Key Labs in the KU-PARI Anatomy Lab for basic anatomy education and surgical training

Cadaver OP Lab for cadaver workshops and related research

Virtual Anatomy and Surgical Simulation Lab

Microsurgery Lab equipped by Zeiss surgical microscopes

“Toward Global Frontier of Creative Medical Research”

Faculty & Research U

nits 08 09

Curriculum03

Biomedical Science aims to protect humans

from diseases and supports well-being

of human life. To accomplish this goal,

biomedical science broadly covers basic

and applied research to understand

mechanisms of pathogenesis and to fi nd

novel methods for preventive, diagnostic,

and therapeutic treatment. Biomedical

science, in particular, is a typical fusion-

science, composed of many disciplines from

biology, pharmacology, physics, chemistry,

engineering, bioinformatics, nanosciences,

and social sciences. The importance of

biomedical science is increasing with social

demands. Accordingly need for experts is

expanding and specialized training systems

are becoming necessary to train leading

experts in the biomedical sciences.

The mission of the Department of

Biomedical Sciences in the Korea University

Graduate Program is to nurture future

leading biomedical researchers through

the provision of relevant, up-to-date

biomedical knowledge, the support of

student’s independent research activities,

and the facilitation of student-professor and

student-student collaboration.

Academic Goals

Code Course Syllabus

BMS

501

Human

Physiology

The objective of this course is to provide information on the mechanisms and physiological functions

of the human body.

BMS

503

Molecular and

Cell Biology

The objective of this course is to provide information on the mechanisms and physiological functions

of the human body.

BMS

504

Introduction to

Clinical Medicine

The objective of this course is to provide understanding of introductory level cell biology, molecular

biology, and biochemistry. This course will cover signal transduction and control mechanisms which are

involved in complex and combined cell states such as structure and function of cellular and biological

molecules, energy production, enzyme epidemiology, mechanism and control, structure and function

of cellular membranes, and structure, function and differentiation of cells. Also, this course will deal

with cellular compartmentalization, movement of macro-molecules, biogenesis of organelles, cell

differentiation, cell movement, and cell conjunction.

BMS

505 -508

Biomedical

Seminars

The aim of this course is to provide an introduction to clinical symptoms, diagnoses and therapies

for various diseases. Also, an objective of this course is to structurally understand diseases by

understanding their etiology.

BMS

509

Foundation of

Biomedical Research

This course introduces guidelines for safe laboratory procedures and ethics for research and laboratory

animals, which are the basis of good biomedical research work.

BMS

510

Advanced Molecular

and Cell Biology

The objective of this course is to study current important topics of molecular and cell biology.

BMS

511

Introduction to

Biomedical Engineering

The aim of this lecture is to learn about various technologies based on engineering for biomedical

research. In this lecture, major topics of biomedical engineering such as medical devices, artifi cial

organs, signal processing and tissue regeneration will be reviewed. Current research status and issues

will be discussed.

BMS

527

Human

Anatomy

The objective of this course is to provide understanding of structure-function relationships of cells,

tissues, and organs and to apply interpreted signs and symptoms in human diseases and injuries.

BMS

528

Omics Convergence

Biomedical Technology

The objective of this class is to understand the state-of-the-art technologies in the fi eld of biomedical

research with special emphasis on the Omics techniques.

BMS

529

Biomedical

Industry

The objective of this class is to provide basic knowledge on biomedical R&D and how to transfer

research fi ndings into industry application.

BMS

530

Introduction to

the Translational Medicine

The aim of this lecture is to learn about basic concepts comprising translational approaches from

views of medicine and basic sciences, and to introduce practical links between the two to accelerate

development of therapeutics.

BMS

531

Introduction to Molecular

and Cell Biology

The objective of this class is to understand the biological bases of cellular functions at a molecular level.

BMS

532

Introduction to human

structure and function

The objective of the class is to introduce the structure and function of the human body, including basic

concepts in human anatomy and physiology.

BMS

639

Medical

Physics

The objective of this course is to provide understanding of models of human body phenomena based

on physical knowledge. Studying physics provides understanding of the mechanisms of action of

medicine and related phenomena.

※ All courses and syllabuses are listed in Appendix II Core Courses

Curriculum 10 11

Tuition fee (waived)The Department of Biomedical Sciences in association with Korea University

Medical Center (KUMC) will provide a grant that equals the tuition fee.

Stipend (complemented)The policy of the department is to guarantee a minimum stipend as follows:

Integrated master and doctoral course: 800,000 KRW (800 USD) per month

for the fi rst 2 years and 1,000,000 KRW per month for the next 4 years

Doctoral course: 1,000,000 KRW per month for 4 years

※ Students have to contact their tentative supervisor before application to

confi rm his/her fi nancial support.

Scholarships04

Eligibility A: An applicant holding foreign citizenship whose parents are

foreign citizens (not Korean citizens).

B: An applicant who completed the entire 16-year education

from elementary school to university in foreign countries (not

Korea).

※ An applicant who would like to apply for the admission

application for foreign students must satisfy one of the

requirements above. An applicant who satisfies all of them is

considered to have the eligibility A. Different requirements will

demand different documents to verify eligibility. Please refer to

the following webpages for more details.

Application Deadline The end of September (Beginning in the following March)

The end of March (Beginning in September)

Requirements Please contact tentative supervisors before your application for

the specific requirements and information.

General information on the graduate programs in Korea

University (KU) is available from the following webpages:

In addition to general documentation, our department requires

following documents:

· A research proposal approved by the tentative supervisor in

the KU Department of Biomedical Sciences

· Two references from his/her current college supervisors

Admission Guide05

Graduate Schoolhttp://graduate2.korea.ac.kr/programs/programs01.jsp

Admissionshttp://graduate2.korea.ac.kr/admission/admission01.jsp

Scholarships / Adm

ission Guide 12 13

Contact Information06Department Offi ceName: KIM, Dong Soon / PARK, Gye Hwa

E-mail: [email protected] / [email protected]

TEL: +82-2-2286-1135, +82-2-2286-1087 FAX: +82-2-2286-1088

Webpage: http://kumcbk21.korea.ac.kr/

Korea University Admission Offi ceName: KIM, Jihyun

E-mail: [email protected]

TEL: +82-2-3290-1358 (English), +82-2-3290-1357 (Chinese)

Webpage: http://graduate2.korea.ac.kr/programs/programs01.jsp

Foreign Students’ Community (Dept of Biomedical Sciences)Name: Mohammed R. Shaker

Webpage: https://www.facebook.com/bk21Foreignstudents

Location

By Subway Line 6 Anam Station Exit 1By Bus 101, 101, 111, 144, 163, 1017, 7211, Seongbuk 04, 1222, 273, 1111

By Car 150m on Inchon-ro(street) and 20m to the rightKorea University College of Medicine Inchon-ro, Seongbuk-gu,Seoul 136-705,Korea

Tel 82-2-2286-1139 Fax 02-924-4958

A. Main Hall, College of Medicine 1st fl oor Laboratory Animal Research Center 2nd fl oor Yookwangsa Hall, Dean’s offi ce, Center for Teaching and Learning, Department of Academic Affairs for College of Medicine, Medical Academic & Student Affairs Team , Research Administrative Team, cafeteria 1, cafeteria 2 3rd fl oor Lecture room, Dean’s offi ce for graduate school of clinical dentistry, Gwanbo Lounge, Headquarter of Medical Center (President’s offi ce’, Hospital director’s offi ce, Head conference room) 4th fl oor Lecture room, Academic affairs department for graduate school of clinical dentistry, Academic affairs department for graduate school of public health, Dean’s offi ce for graduate school of public health, Lounge, Outdoor garden 5th fl oor Ca-daver OP Room, Anatomy Lab, Virtual Anatomy & Surgical Simulation Lab, Microsurgery Lab, Practical Anatomy Research Institute 6th fl oor Medical science research center (Anam), Faculty lab, Common equipment room, DNA bank (Depression center), Cancer Research Lab, Pharmacogenomic Research Center for Psychotropic Drug 7th fl oor Medical science research center, Anam research center, General Research Equipment Laboratory, Stem Cell Lab, BSL 3 Lab

B. Moonsook medical Science Hall 1st fl oor Lecture room, Club room, Conference room, Alumni offi ce, Donation offi ce 2nd fl oor Department of Pre-ventive Medicine 3rd fl oor Department of Biochemistry & Molecular Biology 4th fl oor Department of Pharmacology 5th fl oor Department of Anatomy 6th fl oor Department of Microbiology 7th fl oor Department of Physiology

C. Medical Hall 1 1st fl oor Administrative offi ce for Anam hospital, Cochrane offi ce 2nd fl oor KU-KIST graduate school, Fitness room, Club room 3rd fl oor Department of Biostatistics, Common research support offi ce, Microscope Room, Administrative offi ce for Medical Center 4th fl oor Department of Medical Humanities, Department of Parasitology, Lab, Lecture room 5th fl oor Department of Neural Sciences, Information data processing Lab, Department of Forensic Medicine, Department of Pathology, NFS local offi ce, Lecture room

D. Medical Library 1st fl oor Serials Room 2nd fl oor Seminar room, Electronic Information Room 3rd fl oor Monographs Room(Circulation/Cataloging), Reading room 1,2,3,4,5

Korea University Anam Hospital

KU

Seoul

AMain Hall,

College of Medicine

DMedical Library

BMoonsook

Medical Science Hall

CMedical Hall 1

Parking Lot

Entrance Anam Station

Campus Map 07Contact Inform

ation / Campus M

ap 14 15

Basic Research Units

Faculty & Laboratories01Appendix

Professor Laboratory

CHOI, Hyuk Lab of Biomedical Engineering

GEUM, Dongho Lab of Stem Cell Biology

HAN, Hee Chul Neuroscience Research Institute

HWANG, Jong-Ik Lab of GPCR and Signal Transduction

HWANG, Sun Wook Lab of Sensory Neuroscience

KEE, Sun-Ho Lab of Cell Biology

KIM, Dong-Hoon Lab of Metabolic Disease

KIM, Hyeon Soo Lab of AMPK Signal Transduction

KIM, Hyun Lab of Molecular & Behavioral Neurobiology

KIM, Tae Woo Lab of Tumor-Immune Dynamics

KIM, Won-Ki Lab of Neuroscience

KIM, Yang In Lab of Circadian Rhythm and Hypertension

LEE, Eun Il Lab of Environment & Healthy Longevity

LEE, Kyung-Mi Lab of Global Immunology Research

MIN, Bon Hong Lab of Molecular Pharmacology

NA, Heung Sik Lab of Sensory Abnormalities; Pain and Itch

OH, Jun Seo Lab of Matrix Biology

PARK, Hae Chul Lab of Neurodevelopmental Genetics

PARK, Yongdoo Lab of Cell and Tissue Engineering

RHYU, Im Joo Lab of Brain Structure and Neural Network

SEONG, Jae Young Lab of GPCR and Signal Transduction

SHIN, Ok Sarah Lab of Infection and Immunity

SON, Gi Hoon Lab of Molecular Networks and Neurobiology

SONG, Hoseok Lab of Cancer Biology

SONG, Jin Won Lab of Molecular Virology

SUL, Dong Geun Lab of Biomedical Proteomics

SUN, Woong Lab of Neural Development and Stem Cell Research

YOON, Young Wook Department of Physiology

Appendix 01 Faculty &

Laboratories 16 17

Lab of Biomedical Engineering

PI: Hyuk CHOI, Ph.D. Department of Biomedical Sciences

Contact Information E-mail: [email protected] Tel: +82 2 2626 3302 (Offi ce) / +82 2 2626 2420 (Lab) Website: http://ibr.korea.ac.kr

Professor Choi is interested in and recognized the needs of convergence of medicine, engineering, and life science. Var-ious convergence studies are lively being researched. Most of all, organ chip development using MEMS technology and application of this research to observe traction force between intervertebral disc cells is being studied. Also, micro fl uidics based cell mechanism through CFD simulation, rehabilitation robot development of senior patients, and reliability and performance evaluation of medical devices are actively being studied.

Convergence Medical Device and Robot DevelopmentGOAL

1 H.Choi et al (2014) Integration of microfl uidic chip with biomimetic hydrogel for 3D controlling and monitoring of cell alignment and migration. J Biomed Mater Res A 102(4):1164-72.

2 H.Choi et al (2013) New computerized indices for quantitative evaluation of depression and asymmetry in patients with chest wall deformities. Artif Organs 37(8):712-8.

3 H.Choi et al (2013) Effect of biphasic electrical current stimulation on IL-1β-stimulated annulus fi brosus cells using in vitro microcurrent generating chamber system. Spine (Phila Pa 1976) 38(22):E1368-76.

4 H.Choi et al (2013) A comparative reliability and performance study of different stent designs in terms of mechanical properties: foreshortening, recoil, radial force, and fl exibility. Artif Organs 37(4):368-79.

5 H.Choi et al (2013) Reference values for nerve ultrasonography in the upper extremity. Muscle Nerve. 47(6):864-71.

Organ Chip Study Based on Micro Fluidics Traction Force Research Computational Fluidic Dynamics Cell kinetics analysis & molecular works

Development of Rehabilitation Robot & Devices Finite Element Analysis Hardware & Firmware development Software development

Research Interest

Reliability Evaluation of Medical Devices Life Data Analysis such as MTTF, RCA, and Hazard, etc. High Risk Devices SOP development

Featured Publications

Lab of Stem Cell Biology

PI: Dongho GEUM, Ph.D. Department of Biological Sciences

Contact Information E-mail: [email protected] Tel: +82 2 2286 1091 (Offi ce) / +82 2 2286 1325 (Lab)

Professor Geum is interested in the function of adult neurogenesis on mood disorder. He uses genetically modifi ed mice to ablate neural stem cells in the adult brain, and examines the relationship between mood disorder and the fates of neu-ral stem cells, progenitors and mature neurons in the hippocampus. His research interest extends to bipolar disorder. He made iPS cells from bipolar disorder patients, and is now analyzing monoamine neurons differentiated from iPS cells and screening new drugs for bipolar disorder patients.

Molecular Mechanism of Depression and Bipolar DisorderGOAL

1 H. Lee et al (2013) Circadian rhythm hypothesis of mixed features, antidepressant treatment resistance and manic switching in bipolar disorder. Psychiatry Investig. 10(3):225-32.

2 Y. Park et al (2013) NonO binds to the CpG island of oct4 promoter and function as a transcriptional activator of oct4 gene expression. Mol Cells 35(1):61-9.

3 Y. Park et al (2011) Human feeder cells can support the undifferentiated growth of human and mouse embryonic stem cells using their own basic fi broblast growth facors. Stem Cells Dev. 20(11): 1901-10.

4 M. Hwang et al (2008) The neuronal differentiation potential of Ldb1-null mutant embryonic stem cells is dependent on extrinsic infl uences. Stem Cells 26(6):1490-5.

5 G. Son et al (2006) Maternal stress produces learning defi cits with impairment of NMDA receptor mediated synaptic plas-ticity. J. Neurosci. 26(12):3309-18.

Adult neurogenesis and mood disorder

Research Interest

Generarion of Bipolar disorder patients’ iPS cells and analyzing dopaminergic neurons differentiatiod for m iPS cells



Laboratories 18 19

Lab of GPCR and Signal Transduction

PI: Jong-Ik HWANG, Ph.D. DVM Department of Biomedical Sciences

Contact Information E-mail: [email protected] Tel: +82 2 2286 1093 (Offi ce) / +82 2 2286 1092 (Lab) Homepage: http://gpcr.or.kr

JIH is interested in mechanisms underlying infl ammatory processes which are deeply related to various patho-physiolog-ical conditions, such as cancer, fi brotic organ failure, and transplantation. Particularly, G-protein coupled receptors (GP-CRs)-related signal transduction and NF-kB activation machineries are his main research topics. Using molecular and bio-chemical tools he is investigating molecular interaction of signaling proteins and the functional meaning of the interaction in terms of cellular responses. He is also interested in development of animal models of cancer progression and fi brosis.

Validation of therapeutic targets in infl ammation and cancersGOAL

1 You et al. (2014) A Splicing Variant of NME1 Negatively Regulates NF-kB Signaling and Inhibits Cancer Metastasis by Interacting with IKKb. J. Biol. Chem. 289: 17709.

2 Park et al. (2014) Apoptotic Death of Prostate Cancer Cells by a Gonadotropin-Releasing Hormone-II Antagonist. Plos ONE 9:e99723.

3 Hwang et al. (2013) Expansion of secretin-like G protein-coupled receptors and their peptide ligands via local duplica-tions before and after two rounds of whole genome duplication. Mol Biol Evol 30:1119.

4 Hurh et al. (2013) Expression Analysis of Combinatorial Genes Using a Bi-Cistronic T2A Expression System in Porcine Fibroblasts. Plos ONE 8:e70486

5 Kim et al. (2011) Suppression of NF-κB signaling by KEAP1 regulation of IKKβ activity through autophagic degradation and inhibition of phosphorylation. Cell. Signal. 22:1645

Research Interest


Lab of Sensory Neuroscience

PI: Sun Wook HWANG, Ph.D. Depts of Biomedical Sciences & Physiology


Senses including touch and pain are the ways we feel the internal and external environment. SWH is studying the sensory mechanisms in the context of neurobiology. Particularly, he is focusing on the identities and functions of interface molecules located in the nerves and skin, transducing environmental changes into neural signals that eventually arrive at the brain. He is also trying to fi nd chemical modulators for these sensory molecules that may modify our sensation or alleviate pain.

Exploring sensory mechanisms and developing their chemical modulatorsGOAL

1 Chiu et al. (2013) Bacteria activate sensory neurons that modulate pain and infl ammation. Nature 501:52

2 Chatzigeorgiou et al. (2013) tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans. Nature 494:95

3 Bang et al. (2012) Nociceptive and pro‐infl ammatory effects of dimethylallyl pyrophosphate via TRPV4 activation. Br J Phar-macol 166:1433

4 Chatzigeorgiou et al. (2010) Specifi c roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors. Nat neurosci 13:861

5 Bang et al. (2010) Farnesyl pyrophosphate is a novel pain-producing molecule via specifi c activation of TRPV3. J Biol Chem 285:19362

Research Interest



Laboratories 20 21

Lab of Metabolic Disease

PI: Dong-Hoon KIM, M.D., Ph.D. Department of Pharmacology and Biomedical Sciences


DHK is interested in the interaction between CNS and periphery in the control of food intake and glucose related to adi-pose tissue vasculature. He is studying “previously unknown” crosstalk between the status of adipose tissue vasculature and CNS. He is also focusing on identifying the role of new players in the regulation of energy andglucose homeostasis.

Identifi cation of Novel Players for Metabolic DiseaseGOAL

1 Kim et al. (2013) Central administration of metformin into the third ventricle of C57BL/6 mice decreases meal size and number and activates hypothalamic S6 kinase. Am J Physiol Regul Integr Comp Physiol 305(5):R499.

2 Kim et al. (2013) Metformin decreases meal size and number and increases c-Fos expression in the nucleus tractus sol-itarius of obese mice. Physiol Behav 17;110-111:213.

3 Kim et al. (2013) Increased adipose tissue hypoxia and capacity for angiogenesis and infl ammation in young diet-sensi-tive C57 mice compared with diet-resistant FVB mice. Int J Obes 37(6):853.

4 Kim et al. (2012) Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium. Diabetes 61(9):2299.

5 Kim et al. (2010) Peptide designed to elicit apoptosis in adipose tissue endothelium reduces food intake and body weight. Diabetes 59(4):907.

Research Interest


Discovery of Novel Adipokines

Discovery of Predictors for Obesity and Diabetes

Mechanisms underlying the Benefi cial Effects of Bariatric Surgery

Role of Novel Player in Energy and Glucose Homeostasis

Brain-WAT Vasculature Axis

Kim et al., Diabetes 2010; Kim et al., Diabetes 2012

Molecular & Metabolic Phenotyping Approaches

Lab of AMPK Signal Transduction

PI: Hyeon Soo KIM, M.D & Ph.D. Department of Anatomy

Contact Information E-mail: [email protected] Tel: +82 2 2286 1151 (Offi ce) / Fax: +82 2929 5696

His research topic is AMPK, particularly in diabetes and cancer. His research aim is searching for new AMPK activator, inter-acting protein and substrate. His aim is to understand diabetes and cancer in the molecular level. Now, he identifi ed several novel AMPK activators, binding proteins, and substrates and characterizing its signal network analysis in vitro. His conclusive goal is to provide molecular candidate for the development of treatment dug for diabetes and cancer.

Molecular understanding of diabetes and cancerGOAL

1 Kim et al. (2014) AMPKα2 translocates into the nucleus and interacts with hnRNP H: Implications in metformin-medi-ated glucose uptake. Cell Signal 26:1800-6.

2 Lee et al. (2013) E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal mus-cle C2C12 cells. J Biol Chem 288: 4673-80.

3 Lee et al. (2012) Metformin regulates glucose transporter 4 (GLUT4) translocation through AMP-activated protein ki-nase (AMPK)-mediated Cbl/CAP signaling in 3T3-L1 preadipocyte cells. J Biol Chem 287: 44121-9.

4 Kim et al. (2011) The glutamate agonist homocysteine sulfi nic acid stimulates glucose uptake through the calcium-de-pendent AMPK-p38 MAPK-protein kinase C zeta pathway in skeletal muscle cells. J Bio Chem 286:7567-76.

5 Lee et al. (2008) Retinoic acid leads to cytoskeletal rearrangement through AMPK-Rac1 and stimulates glucose uptake through AMPK-p38 MAPK in skeletal muscle cells. J Bio Chem 283:33969-74.

Research Interest


Role of AMPK regulator Novel AMPK activator In vitro glucose uptake Insulin s ensitizing effect

Novel nuclear role of AMPK Nuclear translocation Target gene Mutagenesis

novel substrate of AMPK 2-D + phospho staining MALDI-TOF/Blast search AMPK consensus motif


Laboratories 22 23

Lab of Molecular & Behavioral Neurobiology

PI: Hyun KIM, M.D., Ph.D. Department of Anatomy & Neuroscience

Contact Information E-mail: [email protected] Tel: +82 2 2286 1153 (Offi ce) / +82 2 2286 1384 (Lab) Homepage: http://braingene.com

HK’s main research interests are in molecular and neural mechanisms underlying synaptic plasticity and psychiatric disor-ders. More specifi cally, he has focused on the neural activity-dependent protein in synapse and its physiological function. He is also trying to reveal depression-related genes in habenula and to implicate them to treatment of depressive disorder.

Understanding the Molecular and Neural Basis of Brain Function and DiseaseGOAL

1 Han et al. (2014) Impaired extinction of learned contextual fear memory in early growth response 1 knockout mice. Mol Cells. 37(1):24-30.

2 Lee et al. (2013) MDGAs selectively interact with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development. PNAS. 110(1): 336-341.

3 Mo et al. (2012) Preso regulation of dendritic outgrowth through PI(4,5)P2–dependent PDZ interaction betaPix. Eur. J. Neurosci. 36: 1960–1970.

4 Lee et al. (2012) Inositol 1,4,5 trisphosphate 3-kinase A is a novel microtubule-associated protein: PKA-dependent phos-phoregulation of microtubule binding affi nity. J Biol Chem. 287(19):15981-15995.

5 Kim et al. (2009) Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling. J Neurosci. 29(44):14039-14049.

Research Interest


Lab of Tumor-Immune Dynamics

PI: Tae Woo KIM, Ph.D. Depts. of Biomedical Sciences & Biochemistry

Contact Information E-mail: [email protected] Tel: +82 2 2286 1305 (Offi ce) / +82 2 2286 1301 (Lab.)

We are trying to understand tumor-immune dynamics to overcome immune resistance of tumors. Recent research clearly demonstrate that the immune system plays a fundamental role in combating tumors. However, fundamental questions how tumors acquire intrinsic and acquired resistance to immune-cell killing remain. Therefore, we aim to elucidate the multidimensional, nonlinear nature of the interaction between immune and tumor to realize the ideal goal of cancer immunotherapy.

Understanding of Tumor-Immune Dynamics for Better Cancer ImmunotherapyGOAL

1 Kim et al. (2003) Enhancing DNA Vaccine Potency by Co-Administration of DNA Encoding Anti-Apoptotic Proteins, J. Clin. Invest., 112(1):109.

2 Kang et al. (2010) Ectopic Expression of X-linked Lymphocyte-Regulated Protein pM1 (XLR) Renders Tumor Cells Resis-tant to Anti-Tumor Immunity, Cancer Res. 70(8):3062.

3 Noh et al. (2012) Cancer vaccination drives Nanog-dependent evolution of tumor cells towards an immune-resistant and stem-like phenotype, Cancer Res. 72(7):1717.

4 Noh et al. (2012) Nanog signaling in cancer promotes stem-like phenotype and immune evasion, J Clin Invest. 122(11):4077.

5 Noh et al. (2014) API5 confers tumor immune resistance through an FGF2/FGFR1/PKCδ-dependent cell survival pathway, (In press, Cancer Research).

Research Interest



Laboratories 24 25

Lab of Neuroscience

PI: Won-Ki KIM, Ph.D. Department of Neuroscience Director, Research Institute for Infl ammation Control

Contact Information E-mail: [email protected] Tel: +82 2 920 6094 (Offi ce) / +82 2 2286 1095,6 (Lab)

The study goal of our laboratory is to elucidate the cell death cascades in cerebral ischemia and to discover and develop novel neuroprotectants. We study the effi cacy and mechanism of action of the protectants in in vivo and in vitro exper-imental models. Additionally, we actively collaborate with pharmaceutical companies to evaluate the pharmacokinetic properties and toxicological activities of the drug candidates.

Drug Development for Ischemic Stroke TherapyGOAL

1 Kim C, Yun N, Lee YM, Jeong JY, Baek JY, Song HY, Ju C, Youdim MB, Jin BK, Oh YJ, Kim WK, Gel-based protease proteom-ics for identifying the novel calpain substrates in dopaminergic neuronal cell. J. Biol. Chem. 2013 Dec 20;288(51):36717-32

2 Choi et al (2013) Activation of cannabinoid CB2 receptor-mediated AMPK/CREB pathway reduces cerebral ischemic injury. Am. J. Pathol. 182(3):928-39

3 Cho et al. (2013) N-Methyl-D-aspartate receptor antagonists memantine and MK-801 attenuate the cerebral infarct ac-celerated by intracorpus callosum injection of lipopolysaccharides. Neurosci. lett. 538:9-14

4 Ju et al (2013) Up-regulation of astroglial heme oxygenase-1 by a synthetic (S)-verbenone derivative LMT-335 ameliorates oxygen-glucose deprivation-evoked injury in cortical neurons. Biochem. Biophy. Res. Comm. 431(3):484-9

5 Choi et al (2011) A3 adenosine receptor agonist reduces brain ischemic injury and inhibits infl ammatory cell migration in rats. Am. J. Pathol. 179(4):2042-52

Research Interest


Animal Ischemic Stroke Model Life Data Analysis such as MTTF, RCA, and Hazard, etc. High Risk Devices SOP development

Cell Culture System Neuron, glia primary culture. Treatment: Oxygen glucose deprivation/Reperfusion, NMDA, Cytokine, LPS etc.

Assay: Cell viability, Ca2+ infl ux, Cell migration, Cytokine, ROS, NO, etc.

Lab of Environment & Healthy Longevity

PI: Eunil LEE, M.D., Ph.D. Department of Biomedical Sciences


Professor Lee is interested in novel environmental effects to human health. Main research topics are to evaluate the healthy longevity mechanisms under pressure environment and short & long term effects by light at night (LAN) environ-ment, and to estimate chronic diseases effects by weather conditions including climate change.

Promotion of Human Health by Environmental Modifi cationGOAL

1 S.Lee et al (2014) Short-term effect of temperature on daily emergency visits for acute myocardial infarction with thresh-old temperatures. PLoS ONE 9(4):e94070

2 E.Hong et al (2012) Tissue-specifi c and age-depedent expresssion of protein arginine methyltransferases (PRMTs) in male rat tissue. Biogerontology 13(3) 329

3 S.Oh et al (2010) Elevated pressure, an novel cancer therapeutic tool for sensitizing cislatin-mediated apotptosis in A549. BBRC 399: 91

4 S.Oh et al (2010) Role of elevated pressure in TRAIL-induced apoptosis in human lung carcinoma cells. Apoptosis 15(12):1517

5 Y.Lim et al (2010) Proteomic identifi cation and comparative analysis of asymmetrically arginine-methylated proteins in immortalized, young and senescent cells. Electrophoresis 31: 3823

Research Interest


Research of the regulatory mechanisms by pressure Healthy longevity Cellular i ntegrity Epigenetic c hange

Development of Health Risk Assess-ment Technology and System of Light Pollution Human health risk assessment for Light pollution Light pollution related biomarkers discover-ing and development

Health Effects by Climate Change Time series analysis to evaluate(estimate) health effects Use of the various climate indices with GIS mapping


Laboratories 26 27

Lab of Global Immunology Research

PI: Kyung-Mi LEE, Ph.D. Department of Biochemistry

Contact Information E-mail: [email protected] Tel: +82 920 6253 (Offi ce) / +82 920 6251 (Lab)

Tumor Immunotherapy employing NK and T cells Converging Biomedical Engineering with Cell Therapy Stem Cell Therapy for Knee regeneration Development of Cell-based combination therapies for resistant tumors Understanding Allergies/Infection/Autoimmune Diseases utilizing gene-defi cient mouse models, 2B4, CD160, BTLA, Light, HVEM..

To develop novel therapies of cancer and immune-related diseases by investigating the basis of immune dysregulation

GOAL

1 Seon Ah Lim, Tae-Jin Kim, Jung Eun Lee, et al.(2013) Ex vivo expansion of highly cytotoxic human NK cells by cocultivation with irradiated tumor cells for adoptive immunotherapy. Cancer Res. (IF 8.65)

2 Kim et al. (2014) Innate Lympoid cells control NK cell development through lymphotoxin mediated control of the stromal microenvironment. J Exp Med. (IF 13.214)

3 Kyung Hee Noh, Seok-Ho Kim, Jin Hee Kim, et al.(2014) API5 Confers Tumoral Immune Escape through FGF2-Dependent Cell Survival Pathway. Cancer Res. (IF 8.65)

4 Hwang et al. (2014) Dissolution Chemistry and Biocompatibility of Single-Crystalline Silicon Nanomembranes and Associ-ated Materials for Transient Electronics. ACS Nano. (IF 12.062)

5 Hwang et al. (2014) Materials for high performance biodegradable semiconductor devices. Advanced materials. (IF 14.829)

Research Interest


Applying Biomedical Engineering tools into Cancer Immunotherapy

Cell-Based Combination Therapies for Resistant Tumors

NK cells and T cells for Cancer Immunotherapy

Lab of Molecular Pharmacology

PI: Bon Hong MIN, Ph.D. Department of Pharmacology

Contact Information E-mail: [email protected] Tel: +82 2 2286 1128 (Offi ce) / +82 2 2286 1401(Lab)

BHM’s research interest is to understand molecular mechanisms underlying cancer cell metastasis and chemo-resistance of clusterin that has been shown to be a stress-activated, antioxidant, and cytoprotective chaperone protein. We also investi-gate the role of clusterin as a modulator of microenvironment in cancer metastasis, infl ammation, and tissue regeneration processes. Presently, we reported that clusterin induces chemotatic migration of macrophages and regulates MMP-9 and TNF-a secretion via GPCR/TLR4 signal for ECM modulation and infl ammatory processes in microenvironment of tumor tissues using cell culture system and purifi ed clusterin protein. To further confi rm the roles of clusterin in vivo, we are now generating clusterin knock-in transgenic mice for tissue specifi c expression using Cre-lox system in ROSA-26 locus.

1 1. Kang et al. (2014) Clusterin stimulates the chemotactic migration of macrophages through a pertussis toxin sensitive G-protein-coupled receptor and Gβγ-dependent pathways. BBRC 445(3):645.

2 Kwon et al. (2014) Defi ciency of clusterin exacerbates high-fat diet-induced insulin resistance in male mice. Endocrinology 155(6):2089.

3 Shim et al. (2012) Clusterin induces the secretion of TNF-α and the chemotactic migration of macrophages. BBRC 422(1):200

4 Lee et al. (2012) Over-expression of human clusterin increases stress resistance and extends lifespan in Drosophila melanogaster. BBRC 420(4):851.

5 Shim et al. (2011) Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-κB pathways in monocytes/macrophages. J. Leukoc. Biol. 90(4):761.

Research Interest



Laboratories 28 29

Lab of Sensory Abnormalities; Pain and Itch

PI: Heung Sik NA, M.D., Ph.D. Department of Physiology


Pain and itch are unpleasant sensations, accompanied with the withdrawal and scratching refl exes, respectively, which help us avoid harmful stimuli. However, these warning bells might comprise remarkably the quality of your life when they become chronic condition. We are interested in chronic pain and itch, particularly nerve injury-induced pain, called neuro-pathic pain and incessant itch in atopic dermatitis, and looking for the cellular or molecular basis for these chronic neural diseases using our own animal models.

1 Jeong et al. (2014) Juvenile obesity aggravates disease severity in a rat model of atopic dermatitis. AAIR (in press).

2 Back et al. (2012) Chronically relapsing pruritic dermatitis in the rats treated as neonate with capsaicin; a potential rat model of human atopic dermatitis. J Dermatol Sci 67:111.

3 Kim et al. (2012) TRPV1 in GABAergic interneurons mediates neuropathic mechanical allodynia and disinhibition of the nociceptive circuitry in the spinal cord. Neuron 74:640.

4 Back et al. (2006) Loss of spinal μ-opioid receptor is associated with mechanical allodynia in a rat model of peripheral neuropathy. Pain 123:117.

5 Na et al. (1994) A behavioral model for peripheral neuropathy produced in rat’s tail by inferior caudal trunk injury. Neu-rosci Lett 177:50.

Research Interest


Neuropathic pain Behavioral studies with several animal models Molecular and cellular mechanisms of central sensitization Pharmacological intervention

Chronic itch in atopic dermatitis Cross-talking mechanisms among keratino-cytes, immune cells and nerves in the skin

Development of novel analgesics and antipruritics Digging out the target molecules and development of new drug candidates Collaboration with domestic drug manufac-turers Omega conotoxins, Patent No: US08673856 (2014.03.18) Benzoxazole derivatives for pruritus amelio-ration, Application No: 10-2014-0011372 (2014.01.29)

Lab of Matrix Biology

PI: Junseo OH, Ph.D. Department of Biomedical Sciences


Our laboratory has focused on two research area; fi brosis and cancer biology. Over the last three decades, much efforts have been paid to elucidate the molecular mechanism for the development of tissue fi brosis and develop the effective an-ti-fi brotic drug. Unfortunately, there is no appropriate therapy available at present. Cancer is likewise one of the obstinate diseases. We have previously demonstrated a novel role of albumin in hepatic stellate cells and proposed a recombinant fusion protein of albumin-RBP as a potential anti-fi brotic drug.

Development of anti-fi brotic therapyGOAL

1 Park S et al (2012) Retinol binding protein-albumin domain III fusion protein deactivates hepatic stellate cells. Mol Cells. 34(6), 517-22.2.

2 Choi S et al (2012) Recombinant fusion protein of albumin-retinol binding protein inactivates stellate cells. Biochem. Biophys. Res. Commun. 418(1), 191-7.

3 Erkan M et al (2012) StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut. 61(2), 172-8.

4 Kim N et al (2010) Albumin mediates PPAR-g and C/EBP-a -induced phenotypic changes in pancreatic stellate cells. Bio-chem. Biophys. Res. Commun. 391(1), 640-644.

5 Kim N et al (2009) Formation of vitamin A lipid droplets in pancreatic stellate cells requires albumin. Gut 58(10), 1382-90.

Research Interest


Albumin inactivated stellate cells Construction of retinol-binding protein (RBP)-albumin fusion protein

RBP-albumin fusion protein reduces liver fi brosis


Laboratories 30 31

Lab of Neurodevelopmental Genetics

PI: Hae Chul PARK, Ph.D. Department of Biomedical Sciences


Professor HCP is interested in neural development and related diseases in the central nervous system. His research is focused on oligodendrocyte developemt and multiple sclerosis, motor neuron development and amyotrophic lateral scle-rosis, and novel neuropeptide screening and functional analysis. Zebrafi sh is one of the most famous vertebrate anmimal model and Prof. Park’s lab established techniques for the generation of KO zebrafi sh and transgenic zebrafi sh to study CNS development and diseases.

Understanding CNS diseases and underling mechanismsGOAL

1 Chung et al. (2013) Generation of demyelination models by targeted ablation of oligodendrocytes in the zebrafi sh CNS. Molecules and Cells 36, 82-87.

2 Chung et al. (2013) Indian hedgehog B function is required for the specifi cation of oligodendrocyte progenitor cells in the zebrafi sh CNS. Journal of Neuroscience 33(4), 1728-1733.

3 Kim S et al. (2012) Antagonistic regulation of PAF1C and pTEF-b is required for oligodendrocyte Differentiation. Journal of Neuroscience 32, 8201-8207.

4 Kim S et al. (2010) Visualization of myelination in GFP-transgenic zebrafi sh. Developmental Dynamics 239, 592-597.

5 Chung et al. (2010) Neuron-specifi c expression of atp6v0c2 in zebrafi sh CNS. Developmental Dynamics 239, 2501-2508.

Research Interest


Lab of Cell and Tissue Engineering

PI: Yongdoo PARK Department of Biomedical Sciences

Contact Information E-mail: [email protected] Tel: 82 2 2286 1458 Homepage: http://cte.korea.ac.kr

The aim of my research is to investigate the morphogenic tissue regeneration, which is closely linked to cellular behavior in 3D. Engineering cellular environments such as chemical or physical factors determines the major factors for tissue mor-phogenesis in regeneration and development

From cells to Tissues for morphogenic regenerationGOAL

1 M. Song et al. (2014) Regeneration of chronic myocardial infarction by injectable hydrogels containing stem cell homing factor SDF-1 and angiogenic peptide Ac-SDKP. Biomaterials 35(8): 2436-2445

2 Hong et al. (2013) Cellular behavior in micropatterned hydrogels by bioprinting system depended on the cell types and cellular interaction. Journal of Bioscience and Bioengineering 116(2): 224-230

3 Kim et al. (2011) The enhancement of mature vessel formation and cardiac function in infarcted hearts using dual growth factor delivery with self-assembling peptides. Biomaterials 32(26): 6080-6088

4 Park, et al. (2007) Carbone nanotube monolayer patterns for directed growth of mesenchymal stem cells. Advanced Ma-terials 19(18): 2530–2534

5 Kim et al. (2007) Bone regeneration using hyaluroic acid based hydrogel with bone morphogenic protein-2 and human mesenchymal stem cells. Biomaterials 28(10): 1830-1837

Research Interest


Cell Engineering Tissue Engineering Collective cell migration


Laboratories 32 33

Lab of Brain Structure and Neural Network

PI: Im Joo RHYU, M.D., Ph.D. Department of Anatomy & Neuroscience


Professor Rhyu is a Neuroanatomist with a background in medicine. He is interested in macroscopic and microscopic plastic response of the nervous system in response to various situations, especially motor activities. He demonstrated mac-roscopic plastic change of athletes’ brains with MRI. He investigates the ultrastructure of synapse with various electron microscopic techniques to understand the synaptic machinery and its roles in physiological and pathological conditions of the living.

To understand brain function based on morphological evidencesGOAL

1 Lee et al. (2014) Synapses need coordination to learn motor skills. Rev Neurosci. 25(2):223-30.

2 Lee et al. (2013) Motor skill training induces coordinated strengthening and weakening between neighboring synapses. J Neurosci. 33(23):9794-9.

3 Park et al. (2013) Regional cerebellar volume refl ects static balance in elite female short-track speed skaters. Int J Sports Med. 34(5):465-70.

4 Kim et al. (2013) Three-dimensional imaging of cerebellar mossy fi ber rosettes by ion-abrasion scanning electron micros-copy. Microsc Microanal. 5:172-7.

5 Kim et al. (2012) Growth patterns for acervuli in human pineal gland. Sci Rep. 2:984.

Research Interest


Neuropathic pain Synaptic plasticity in learning & memory Synaptic vesicle release mechanism

Motor Coordination Acrobat training model Cerebellum development & related disease Human MRI volumetric study

Electron Microscopic Analysis Electron tomography Serial sectioning Electron Microscopy High voltage electron microscopy

Lab of GPCR and Signal Transduction

PI: Jae Young SEONG, Ph.D. Department of Biomedical Sciences

Contact Information E-mail: [email protected] Tel: +82 2 2286 1090 (Offi ce) / +82 2 2286 1092 (Lab) Homepage: http://gpcr.or.kr

JYS is interested in G-protein coupled receptors (GPCRs), particularly, neuropeptide GPCRs and orphan GPCRs. He is searching for ligands for orphan GPCRs, and investigating molecular interaction between ligands and receptors to devel-op novel agonists and antagonists. He is also studying evolution of neuropeptides and GPCRs using comparative genom-ics and bioinformatics. Bioinformatic tools allow identifi cation of novel uncharacterized neuropeptides.

Development of Drug Candidates for the Treatment of Neuro/Endocrine DiseasesGOAL

1 Kim et al. (2014) Coevolution of the spexin/galanin/kisspeptin family: spexin activates galanin receptor type II and III. Endocrinology 155:1864.

2 Hwang et al. (2013) Expansion of secretin-like G protein-coupled receptors and their peptide ligands via local duplica-tions before and after two rounds of whole genome duplication. Mol Biol Evol 30:1119.

3 Moon et al. (2012) Evolutionarily conserved residues at glucagon-like peptide-1 (GLP-1) receptor core confer ligand-in-duced receptor activation. J Biol Chem 287:3873

4 Lee et al. (2009) Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebrates. Endocrinol-ogy 150:2837.

5 Kim et al. (2009) A gonadotropin-releasing hormone-II antagonist induces autophagy of prostate cancer cells. Cancer Res 69:923.

Research Interest



Laboratories 34 35

Lab of Infection and Immunity

PI: Ok Sarah SHIN, Ph.D. Department of Biomedical Sciences

Contact Information E-mail: [email protected] Tel: +82 2 2626 3280

Our lab focuses on understanding the mechanisms of the innate immune defense against bacterial/viral pathogens, such as Staphlycoccus aureus, infl uenza virus, varicella zoster virus (VZV) and hantavirus. Our ultimate goal is to utilize the knowledge we gain through these areas of research in the rational design of effective vaccines/adjuvants or immunother-apeutics for the prevention of transmission bacterial/viral pathogens.

Understanding of Host-Pathogen Interaction and ImmunosenescenceGOAL

1 Shin et al (2014) Hantaviruses induce antiviral and pro-infl ammatory innate immune responses in astrocytic cells and the brain. Viral Immunology. 2014 Aug;27(6):256-66.

2 Shin et al (2013) Hantaviruses induce cell type- and viral species-specifi c host microRNA expression signatures. Virology. 2013 Nov;446(1-2):217-24

3 Karlsson et al (2013) Natural selection in a bangladeshi population from the cholera-endemic ganges river delta. Science Translational Medicine. 2013 Jul 3;5(192):192ra86

4 Shin et al (2012) Distinct innate immune responses in human macrophages and endothelial cells infected with shrew-borne hantaviruses. Virology. 2012 Dec 5;434(1):43-9.

5 Shin et al (2011) LPLUNC1 modulates innate immune responses to Vibrio cholerae. Journal of Infectious Diseases. 2011 Nov;204(9):1349-57.

Research Interest


Application of Systems Biology to study host immune responses

Investigation of detailed roles and mechanisms of Immunosenescence

Identifi cation of Anti-bacterial/viral molecules and vaccine/adjuvant candidates

Lab of Molecular Networks and Neurobiology

PI: Gi Hoon SON, Ph.D. Department of Biomedical Sciences/Legal Medicine


GHS is mainly interested in circadian rhythm and its implications in psychiatric and metabolic disorders. He is focusing on the issues how molecular circadian clockworks are integrated into the key biological pathways underlying circadian rhythm-related human diseases. In this regard, he is also trying to develop novel small molecules to modulate molecular biological rhythms crucial for human health and diseases.

Developing novel diagnostic and therapeutic targets/strategiesGOAL

1 Chung et al. (2014) Impact of circadian nuclear receptor REV-ERBα on midbrain dopamine production and mood regula-tion. Cell 157:858.

2 Son et al. (2011) The adrenal peripheral clock: impacts on circadian rhythm of glucocorticoid and circadian timing system. Front Neuroendocrinol 32:451.

3 Lee et al. (2011) Impairment of fear memory consolidation in maternally stressed male mice offspring: Evidence for nonge-nomic glucocorticoid action on the amygdala. J Neurosci 31:7131

4 Jo et al. (2010) Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95. Nat Neurosci 13:1216.

5 Son et al. (2008) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhyth-mic steroid production. Proc Natl Acad Sci USA 105:20970.

Research Interest



Laboratories 36 37

Lab of Cancer Biology

PI: Hoseok SONG, Ph.D. Department of Biomedical Sciences


Professor Song is interested in deciphering the roles of microRNAs in governing differentiation and tumorigenesis. He has been using a genetically modifi ed human embryonic stem cell (hESC) line as a model system to exploit its potential to differentiate into various types of cells. Combined with CrossLinking ImmunoPrecipitation (CLIP) and high throughput sequencing, the hESC-based system allows for unbiased, genome-wide analysis of microRNA-mRNA network, which will provide novel insights in the roles of miRNAs in various aspects of biological processes.

Systematic analysis of miRNA-mRNA networkGOAL

1 Seong et al. (2014) Global identifi cation of target recognition and cleavage by the Microprocessor in human ES cell, Nu-cleic Acids Res., in press

2 Jung et al. (2014) Cell cycle-dependent regulation of Aurora kinase B mRNA by the Microprocessor complex, Biochem Biophys Res Commun. 446(1):241

3 Song et al. (2010) Modeling Disease in Human ESCs Using an Effi cient BAC-Based Homologous Recombination System, Cell Stem Cell 6(1):80

4 Song and Xu (2007) Gain of Function of p53 Cancer Mutants in Disrupting Critical DNA Damage Response Pathways, Cell Cycle 6(13):1570

5 Song et al. (2007) p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM, Nat Cell Biol. 9(5):573

Research Interest


Modifi cation of hESC by gene targeting

A hESC-based model system to analyze miRNA-mRNA network

CrossLinking ImmunoPrecipiation (CLIP) method to identify protein-bound RNAs

A target mRNA identifi ed by CLIP

Lab of Molecular Virology

PI: Jin-Won SONG, M.D., Ph.D. Department of Biomedical Sciences

Contact Information E-mail: [email protected] Tel: +82 2 2286 6408 (Offi ce) / +82 2920 6353 (Lab)

Professor Song is interested in global emerging viruses including hantaviruses and polar viruses. For discovery of a new virus, he is conducting serological and molecular studies. Also the novel virus is isolated and mapped by full genome se-quencing. Finally, he analyzes phylogenetic tree of the viruses and establishes their genetic information database. These studies can contribute to develop diagnosis, vaccine and therapy of emerging viral diseases and reduce them.

Virus HunterGOAL

1 Shin OS et al. (2014) Hantaviruses induce antiviral and pro-infl ammatory innate immune response in astrocytic cells and the brain. Viral Immunology.27(6):256-66.

2 Arai.S et al. (2012) Divergent ancestral lineages of newfound hantaviruses harbored by phylogenetically related crocidurine shrew species in Korea. Virology.424(2):99-105.

3 Park YM et al. (2012) Full genome analysis of a novel adenovirus from the South Polar skua (Catharacta maccormicki) in Antarc-tica. Virology.422(1):144-50.

4 Song JW et al. (2009) Characterization of Imjin virus, a newly isolated hantavirus from the Ussuri white-toothed shrew (Crocid-ura lasiura). Journal of Virology.83(12):6184-91.

5 Song JW et al. (1994) Isolation of pathogenic hantavirus from white-footed mouse (Peromyscus leucopus). Lancet.344(8937):1637

1998 Hantaan Prize, The Hantaan Life Science Foundation, Seoul, Korea2011 56th the National Academy of Sciences Award, Korea National Academy of Sciences, Seoul, Korea

Research Interest


Honors and Awards


Laboratories 38 39

Lab of Biomedical Proteomics

PI: Donggeun SUL, Ph.D. Department of Biomedical Sciences


Professor Sul is interest in development of biomarkers related in biomedicine and toxicology using proteomic analysis. Human plasma proteins and cell secreted proteins are major target for proteomic study. Protein based Lab-on-a-chip has been developed to evaluate the exposure rate of environmental toxicants. Recently, IdMOC system has been focused on development of proteomic biomarkers of various drugs.

Development of Proteomic BiomarkersGOAL

1 Choi et al. (2014) Plasma proteomic analysis of patients infected with H1N1 infl uenza virus. Proteomics. In Press.

2 Park et al. (2012) Toxicological biomarkers of 2,3,4,7,8-pentachlorodibenzofuran in proteins secreted by HepG2 cells. Biochim Biophys Acta. 1824(4):656-66.

3 Choi et al. (2010) Identifi cation of toxicological biomarkers of di(2-ethylhexyl) phthalate in proteins secreted by HepG2 cells using proteomic analysis. Proteomics. 10(9):1831-46.

4 Jung et al. (2009) Analysis of low molecular weight plasma proteins using ultrafi ltration and large gel two-dimensional electrophoresis. Proteomics. 9(7):1827-40.

5 Im et al. (2006) Evaluation of toxicological monitoring markers using proteomic analysis in rats exposed to formalde-hyde. J Proteome Res. 2006 Jun;5(6):1354-66.

Research Interest


Development of Lab-on-a-chip of PAH Toxicological biomarkers of drugs using IdMOC system

Lab of Neural Development and Stem Cell Research

PI: Woong SUN Departments of Anatomy and Neuroscience

Contact Information E-mail: [email protected] Tel: +82 2 2286 6404 (Offi ce)

WS has been exploring the molecular and cellular mechanisms of the programmed cell death of neurons in the embry-onic and adult nervous systems under the physiological or pathological settings, with special emphasis on the mitochon-dria-driven death signals. He is also interested in the multidisciplinary fusion researches for in vitro production of neural chips and 3D neuronal tissues from stem cells.

Knowledge-based R&D for brain diseasesGOAL

1 Kim et al. (2014) Surface-printed microdot array chips for the quantifi cation of axonal collateral branching of a single neuron in vitro. Lab Chip, Feb 21; 14(4):799-805.

2 Kim et al. (2013) (ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neu-ronal degeneration in a mouse model of Parkinson’s disease. Cell Death & Dis, 4:e919.

3 Moon et al. (2013) Function of Ezrin-Radixin-Moesin Proteins in Migration of Subventricular Zone-Derived Neuroblasts Following Traumatic Brain Injury. Stem Cells. 31:1696-705.

4 Choi et al. (2013) Drp1-mediated mitochondrial dynamics and survival of developing chick motoneurons during the period of neuronal programmed cell death. FASEB J 27:51-62.

5 Wenlin et al. (2011) Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. PNAS, 108(20):8299-304.

Research Interest


Neuronal Cell Death and neurodegeneration Mechanism of developmental PCD MN death in ALS and PD

Stem Cell Biology of adult neurogenesis Neural stem cell for brain repair Engineering endogenous NSCs

Fusion Research for Neuron chip/3D culture Micro-contact surface pattering Neuronal spheroid culture


Laboratories 40 41

Clinical Research Units

Professor Laboratory

CHO, Jae-Gu Department of Otorhinolaryngology-Head and Neck Surgery

CHOE, Jae Gol Department of Nuclear Medicine

HAM, Byung-Joo Interdisciplinary Affective Neuroscience Lab

HONG, Soon Cheol Lab of Placenta Stem Cells

KIM, Aeree Department of Pathology

KIM, Byung Soo Department of Medical Oncology and Hematology

KIM, Dong-Sik Lab of HBP Surgery & Liver Transplantation

KIM, Hyun Koo Lab of Image-guided Cancer Surgery

KIM, Min Ja Lab of Infection and Immunity

KIM, Woo Joo Department of Infectious Diseases

KIM, Yeul Hong Cancer Research Institute

LEE, Chang Kyu Department of Lab Medicine

LEE, Heon-Jeong Lab of the Circadian Rhythm & Mood Disorders

LEE, Heung Man The Upper Airway Research Institute (TUARI)

LEE, Suk Lab of Medical Physics

LIM, Chae Seung Lab of Biomedical Engineering

LIM, Do-Sun Lab of Cardiac Regeneration

OH, Sang Cheul Lab of Gastrointestinal Cancer Biology

PARK, Jong Woong Hand Surgery & Reconstructive Microsurgery

PARK, Kyong Hwa Department of Medical Oncology and Hematology

RHA, Seung-Woon Cardiovascular Intervention and Research Institute

SEO, Jae Hong Lab of Breast Cancer Targeting Drug

SHIN, Chol Korean Genome and Epidemiology Study (KoGES)

SHIN, Sang-Wan Lab of Dental Research

SON, Sang Wook Lab of Cell Signaling and Nanomedicine

SONG, Hae Ryong Lab of Bone Defect/Disease Fusion-Therapy Center

SUH, Seung-Wo Department of Orthopedic Surgery

YOO, Hye Jin Lab of Diabetes & Atherosclerosis

YOON, Soo-Young Lab of Diagnostic Technology Development


Laboratories 42 43

Lab of Interdisciplinary Affective Neuroscience

PI: Byung-Joo HAM, M.D., Ph.D. Department of Biomedical Sciences


Professor Ham’s research interest is combining interdisciplinary approaches for better understanding of both normal and abnormal affective processes. Various methods complementary to each other including structural/functional neuroimag-ing and epigenetics are adopted to more comprehensive understanding of human affection.

Understanding normal / abnormal mechanisms of human affectionGOAL

1 Han et al. (2014) Cortical thickness, cortical and subcortical volume, and white matter integrity in patients with their fi rst episode of major depression. Journal of Affective Disorders, 155:42-48.

2 Lee & Ham (2008) Serotonergic genes and amydala activity in response to negative affective facial stimuli in Korean women. Genes, Brain and Behavior, 7(8):899-905.

3 Lee et al. (2008) Neural correlates of affective processing in response to sad and angry facial stimuli in patients with major depressive disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32(3):778-785

4 Seok et al. (2013) Effect of the COMT val158met polymorphism on white matter connectivity in patients with major depressive disorder. Neuroscience letters. 545(17):35-39.

5 Lee et al. (2011). DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli. Behavioural Brain Research. 223(1):36-41.

Research Interest


Multimodal Imaging Voxel Volumetry Surface Thickness Analysis Diffuser Tensor Imaging Resting-state fMRI

Genetics & Epigenetics Gene variation & methylation analysis related to individual differences

Major Depressive Disorder & Bipolar Disorders Brain abnormalities related to affective disorders

Lab of Placenta Stem Cells

PI: Soon-Cheol HONG M.D. Ph.D Department of Obstetrics and Gynecology


Prof. Hong is interested in the effect of folic acid for pregnancy women and cell therapy which is derived from human placenta. Especially, he is focused on new drug candidates, and has been continuing to study this experiment. Also, He has been studying developmental toxicity including Folic acid’s functions and cell availability for cell therapy.

To use the placenta stem cells as cell therapy and as the new test for reproductive toxicology

GOAL

1 Kim MW, Ahn KH, Ryu KJ, Hong SC et al. (2014)Preventive effects of folic acid supplementation on adverse maternal and fetal outcomes, PLOS One 2014; 9(5):

2 Cho GJ et al.(2013)Trends in the rates of peripartum hysterectomy and uterine artery embolization ,PLoS One. 2013;8(4):e60512.

3 Postpartum uterine involution: sonographic changes in the endometrium between 2 and 6 weeks postpartum related to mode and gestational age at delivery. Ultrasound Obstet Gynecol 2012 Jun;39(6):727-8

4 Kim MW (2012) Homocysteine, folate and pregnancy outcomes.J Obstet Gynaecol. 2012 Aug;32(6):520-4

5 Hong SC (2010) Stemness Evaluation of Mesenchymal Stem Cells from Placentas According to Developmental Stage: Comparison to Those from Adult Bone Marrow. Journal of Korean Medical Science. 2010, JulyOct;25(10):1418-26

Research Interest



Laboratories 44 45

Lab of HBP Surgery & Liver Transplantation

PI: Dong-Sik KIM, M.D., Ph.D. Division of HBP Surgery & Liver Transplantation, Department of Surgery Department of Biomedical Sciences


DSK is interested in translational research in the fi eld of hepatobiliary disease and liver transplantation. Recent research topics include primary hepatocyte culture using 3-D fl atform, effects of various drugs including immunosuppressives on hepatic steatosis and fi brosis, elucidation of mechanism and therapeutics development for liver regeneration and small-for-size syndrome, ischemia-reperfusion injury in animal models or human transplantation.

1 S. A. Lee, D. Y. No, E, Kang, J. Ju, D. S. Kim and S. H. Lee Spheroid-based three-dimensional liver-on-chip to investigate hepatocyte-hepatic stellate cell interaction and fl ow effects. Lab on a chip 2013; 13(18):3529-3537

2 J.H. Kwo, N. Lee, J. Y. Park, Y. S. Yu, J. P, Kim, J. H. Shin, D. S. Kim, J. W. Joh, D. S. Kim, K. Y. Choi, K. J. Kang, G. Kim, Y. H. Moon and H. J. Wang Actionable gene expression-based patient stratifi cation for molecular targeted therapy in hepatocellular carcinoma. PLoS One 2013;8(6):e64260

3 S. M. Kwon, D. S. Kim, N. H. Won, S. J. Park, Y. J. Chwae, H. C. Kang, S. H. Lee, S. Thorgeirsson, H. G. Woo Genomic copy number alter-ations with transcriptional deregulation at 6p identify an aggressive HCC phenotype. Carcinogenesis 2013;34(7):1543-50

4 D. Y. No, S. A. Lee, Y. Y. Choi, D. Park, J. Y. Jang, D. S. Kim, amd S. H. Lee Functional 3D human primary hepatocyte spheroids made by co-culturing hepatocyte from partial hepatectomy specimen and human adipose-derived stem cells. PLoS One 2012;7(12):e50723

5 Y. D. Yu, D. S. Kim, G. Y. Byun and S. O. Seo Can propranolol be a viable option for the treatment of small-foe-size syndrome? Liver Transpl 2012;18(6):747-8

Research Interest


3D Primary hepatocyte culture Found a relationship between portal fl ow and hepatocyte Designing of 3D culture fl ow chip Improvement of hepatocyte function

Nonalcoholic-Steatohepatitis Development of NASH animal model In vivo, In vitro effi cacy of Immunosuppressives

Small-for-size syndrome Development of liver failure model Choosing the drug candidate In vivo effi cacy of drug candidates

Lab of Image-guided Cancer Surgery

PI: Hyun Koo KIM, MD, Ph.D Department of Thoracic and Cardiovascular Surgery


Prof. Kim’s research interests cover three areas : 1) Intralymphatics delivery system of nanoparticle based chemothera-peutics for cancer treatment, 2) Image-guided cancer surgery using NIR fl uorescent imaging system and 3) Development of smart surgical goggle for image guided cancer surgery. For various research, his lab have collaborated with Dept. of Biomedical Engineering of Korea University, Bio and Brain Engineering of KAIST and Nuclear Medicine of Seoul National University.

1 (2014) Thoracoscopic color and fl uorescence imaging system for sentinel lymph node mapping in porcine lung using indocyanine green-neomannosyl human serum albumin:intraoperative image-guided sentinel nodes navigation. Ann. Surg. Oncol. 6;21(4):1182-8.

2 (2014) Gallium-68 Neomannosylated Human Serum Albumin-Based PET/CT Lymphoscintigraphy for Sentinel Lymph Node Mapping in Non-Small Cell Lung Cancer. Ann Surg Oncol. In press

3 (2014) Needlescopic Resection of Small and Superfi cial Pulmonary Nodule After Computed Tomographic Fluoroscopy-Guided Dual Localization with Radiotracer and Hookwire. Ann Surg Oncol. In press

4 (2013) Intraoperative combined color and fl uorescent images-based sentinel node mapping in the porcine lung: Comparison of indo-cyanine green with or without albumin premixing. J Thorac Cardiovasc Surg 146(6):1509-15

5 (2012) Comparison between Preoperative Versus Intraoperative Injection of Technetium-99 m Neomannosyl Human Serum Albumin for Sentinel Lymph Node Identifi cation in Early Stage Lung Cancer. Ann Surg Oncol. 19:1343-1349

6 (2011) Sentinel node identifi cation using technetium-99m neomannosyl human serum albumin in esophageal cancer. Ann Thorac Surg. 91(5):1517-22.

Research Interest


Intralymphatics chemotherapy NIR Fluorescent imaging system Smart Surgical Goggle System

Minimal Incision and Resection of Tumor using Image-guidance Surgery and Local Chemotherapy

GOAL


Laboratories 46 47

Lab of Infection and Immunity

PI: Min Ja KIM, M.D., Ph.D. Dept. of Internal Medicine, Div. of infectious Diseases


The major topics include elucidation of early host innate immune responses during severe bacterial infection and the related diagnostic, prognostic and therapeutic molecular biomarkers for control of severe bacterial infection. Using the differently susceptible mouse model of Legionnaires’ disease, role and dynamics of immune cells, together with various infl ammatory chemokines and cytokines profi les are being investigated. Especially, genetic difference in activation of infl ammasomes is under exploration as a cytoplasmic sensor for intracellular pathogen. Other topics are development of diagnostic bio-markers based on CGH data for Legionnairs’ disease and characterization of changing patterns of pneumococcal serotypes following pneumococcal vaccination in older people.

1 Yoon YK, Kim MJ et al. (2014) Multicenter prospective observational study of the comparative effi cacy and safety of vancomycin versus teicoplanin in patients with health care-associated methicillin-resistant Staphylococcus aureus bacteremia. Antimicrob Agents Chemother. 58(1):317-324.

2 Yoon YK, Kim MJ et al. (2012) Clinical prediction rule for identifying patients with vancomycin-resistant enterococci (VRE) at the time of admission to the intensive care unit in a low VRE prevalence setting. J Antimicrob Chemother. 2012 Dec;67(12):2963-9.

3 Park DW, Kim MJ et al. (2012) Red blood cell transfusions are associated with lower mortality in patients with severe sepsis and septic shock: a propensity-matched analysis*. Crit Care Med. 40(12):3140-3145.

4 Yoon YK, Kim MJ et al. (2011) Risk factors for prolonged carriage of vancomycin-resistant Enterococcus faecium among patients in intensive care units: a case-control study. J Antimicrob Chemother. 66(8):1831-1838.

5 Shim HK, Kim MJ et al. (2009) Legionella lipoprotein activates toll-like receptor 2 and induces cytokine production and expression of costimulatory molecules in peritoneal macrophages. Exp Mol Med. 41(10):687-694.

NOD-like receptors and Innate immune responses Analysis of innate immune cell activation in mouse model of Legionnaires’ disease pneumonia

Insights into activation of infl ammasomes

Discovery of Diagnostic biomarkers for detection of Legionnaires’ disease CGH-based screening for specifi c candidate genes Development of multiplex real-time PCR assay for rapid detection and differentiation of Legionella species

Research Interest

Serotyping and Diagnostics of Streptococcus pneumoniae Diagnostic approaches to differentiate between invasive and noninvasive pneumococcal diseases and pneumonia and colonization

Multiplex pneumococcal serotyping assay using luminex


Cancer Research Institute

PI: Yeul Hong KIM, MD, Ph.D, Department of Biomedical Sciences

Contact Information E-mail: [email protected] Tel: +829205569(Offi ce)/+82222861258(Lab)

Professor Kim (Director, Korea University Cancer Research Institute) is interested in translational research in lung and GI cancer. Since 2001, many study results was reported through cancer genome research. Recently, using next-generation sequencing (NGS) in lung adenocarcinoma with wild-type EGFR was discovered genomic alterations. Currently, NGS-based cancer panel using tissue and cell free DNA are developing, and carry out gastric cancer stem cell research for the elimina-tion of gastric cancer cells.

1 Jo et al. (2014) EGFR endocytosis is a novel therapeutic target in lung cancer with wild-type EGFR. Oncotarget. 5:1265-78.

2 Kim et al. (2013) Predictive effi cacy of low burden EGFR mutation detected by next-generation sequencing on response to EGFR tyrosine kinase inhibitors in non-small-cell lung carcinoma. PLoS One. 8:e81975.

3 Whang et al. (2013) Wnt5a is associated with cigarette smoke-related lung carcinogenesis via protein kinase C. PLoS One. 8(1):e53012.

4 Ohtsu et al. (2013) Everolimus for previously treated advanced gastric cancer: results of the randomized, double-blind, phase III GRANITE-1 study. J Clin Oncol. 31(31):3935-43.

5 Lan et al. (2012) Genome-wide association analysis identifi es new lung cancer susceptibility loci in never-smoking wom-en in Asia. Nat Genet. 44(12):1330-5.

Research Interest



Laboratories 48 49

Lab of the Circadian Rhythm & Mood Disorders

PI: Heon-Jeong LEE, M.D., Ph.D. Department of Psychiatry Department of Biomedical Sciences

Contact Information E-mail: [email protected] Tel: +82 2 920 6721 (offi ce) Homepage: http://kuhjnv.wix.com/circadianrhythmmood

Circadian rhythms are cyclic and persistent patterns of behavior, physiological changes, and mental characteristics exhibited by most living organisms on the Earth, from bacteria to humans. They occur with a 24-h period and are thus roughly refl ective of the time it takes for the Earth to complete a rotation. Prof. Lee has been interested in correlations of circadian rhythm with mood disorders. He recognized that patients suffering from mood disorders (e.g. bipolar disorder) are in disrupted circadian rhythm. Furthermore, his research team has found out that particular stress such as irregular sleep cycle and light pollution destroys healthy circadian rhythms in a group of people. The molecular mechanisms connecting circadian rhythm with stress and mood disorder are lively being investigated.

Development of new strategies for treating and preventing mood disorders by circadian rhythm consolidation.

GOAL

1 Jung et al. (2014) Association between restless legs syndrome and CLOCK and NPAS2 gene polymorphisms in schizo-phrenia. Chronobiol Int. epub.

2 Lee et al. (2013) Circadian rhythm hypotheses of mixed features, antidepressant treatment resistance, and manic switch-ing in bipolar disorder. Psychiatry Investig. 10:225-32.

3 Lee et al.(2013). A genome-wide association study of seasonal pattern mania identifi es NF1A as a possible susceptibility gene for bipolar disorder. J Affect Disord. 145(2): 200-7.

4 Lee et al. (2011). Delayed sleep phase syndrome is related to seasonal affective disorder. J Affect Disord. 133:573-9.

5 Lee et al. (2011). PER2 Variation is Associated with Diurnal Preference in a Korean Young Population. Behav Genet. 41:273-7.

Circadian Rhythm and Bipolar DisordersCircadian rhythm instability, imposed on the dysregulation of HPA axis and monoamine system, may in turn increase indi-vidual susceptibility for Bipolar disorders.

Polysomnography and Actigraphy Sleep study with full polysomnography and actigraphy are used for the circadian rhythm disturbances.

Circadian Rhythm Management for Mood disorders Invention of gene chip for circadian rhythm Invention of circadian manager using wearable devices

Research Interest


The Upper Airway Research Institute (TUARI)

PI: Heung-Man LEE, M.D., Ph.D. Department of Otorhinolaryngology-Head and Neck surgery, Department of Biomedical Sciences

Contact Information E-mail: [email protected] Tel: +82 2 2626 3185 (Offi ce) / +82 2 2626 1986 (Lab) Homepage: http://tuari.korea.ac.kr/

Professor Lee is interested in therapeutic application and molecular mechanism of airway infl ammatory disease: epigen-etic regulation, natural product test, epithelial to mesenchymal transition, role of infl ammatory cytokine and chemokine, and preclinical study. He is demonstrating and developing newly-characterized nasal stem cells, which have therapeutic effects for airway disease. He is also investigating for airway defense mechanisms induced by environmental particle pol-lution (Particulate matter and Asian sand dust)

Development of therapeutic agent for airway infl ammatory diseaseGOAL

1 Cho JS et al. (2014). Steroids inhibit vascular endothelial growth factor expression via TLR4/Akt/NF-κB pathway in chronic rhinosinusitis with nasal polyp. Exp Biol Med.

2 Cho JS et al. (2013). Activation of TLR4 induces VEGF expression via Akt pathway in nasal polyps. Clin Exp Allergy. 43(9):1038-47.

3 Han DY et al. (2013). Effect of prostaglandin E2 on vascular endothelial growth factor production in nasal polyp fi bro-blasts. Allergy Asthma Immunol Res. 5(4):224-31.

4 Cho JS et al. (2012). Inhibitory effect of ginsenoside Rg1 on extracellular matrix production via extracellular signal-regu-lated protein kinase/activator protein 1 pathway in nasal polyp-derived fi broblasts. Exp Biol Med. 237(6):663-9.

5 Cho JS et al. (2012), Epigenetic regulation of myofi broblast differentiation and extracellular matrix production in nasal polyp-derived fi broblasts. Clin Exp Allergy. 42(6):872-82.

Chronic Rhinosinusitis Therapy Myofi broblast differentiation Extracellular matrix accumulation Epithelial to Mesenchymal transition Infl ammatory cytokine and chemokine

Allergic Disease Therapy Natural products Biochemical Nasal-derived mesenchymal stem cell

Environmental Particle Pollution Particulate matter Asian sand dust ER stress Reactive oxygen species Autophagy

Research Interest



Laboratories 50 51

Lab of Biomedical Engineering

PI: Chae Seung LIM, M.D., Ph.D. Department of Laboratory Medicine


CSL’s main research interests are in development of diagnostic kits. More specifi cally, he has focused on tropical disease like malaria and infl uenza. He is also trying to develop new device to detect drug resistance of malaria.

Development of rapid and effi cient diagnostic system for infectious diseasesGOAL

1 Lee et al. (2014) False positive results for malaria rapid diagnostic tests in patients with rheumatoid factor. Journal of clinical microbiology. 07/2014.

2 Lee et al. (2014) Rapid Detection of Mycobacterium Tuberculosis Using a Novel Ultra-Fast Chip-Type Real-Time PCR System. Chest. 06/2014.

3 Min et al. (2014) Isolation of DNA using magnetic nanoparticles coated with dimercaptosuccinic acid. Analytical Bio-chemistry 447 (2014) 114–118

4 Cho et al. (2014) Measurement of RBC agglutination with microscopic cell image analysis in a microchannel chip . Clin-ical Hemorheology and Microcirculation 56 (2014) 67–74.

5 Cho et al. (2014) Evaluation and Verifi cation of the Nanosphere Verigene RVþ Assay for Detection of Infl uenza A/B and H1/H3 Subtyping. Journal of Medical Virology 05/2014

Development of molecular POCT for malaria

Development of RBC agglutination analyzer

Development of Infl uenza subtyping kits

Research Interest


Lab of Cardiac Regeneration

PI: Do-Sun LIM, MD, Ph.D. Department of Cardiology


Professor Lim is interested in development of a clinically applicable stem cell therapy for treatment of cardiovascular dis-eases. To do this, he is investigating highly effi cient stem cell sources, differentiation methods into functional heart cells, and effi cacy and safety stem cell therapy in animal models with heart diseases. His research has also focused on eluci-dating new biomarkers and developing detection systems for early diagnosis, prognosis and regimen of cardiovascular disease.

Development of Clinically Applicable Cell Therapy & Biomarker Detection SystemGOAL

1 Joo et al. (2014) Smooth muscle progenitor cells from peripheral blood promote the neovascularization of endothelial colony-forming cells. Biochem Biophys Res Commun 449(4):405-11.

2 Choi et al (2012) Nanog regulates molecules involved in stemness and cell cycle-signaling pathway for maintenance of pluripotency of P19 embryonal carcinoma stem cells. J Cell Physiol 227(11):3678-92.

3 Jeong et al (2012) Correlation between circulating angiogenic cell mobilizations and recovery of coronary fl ow reserve in patients with acute myocardial infarction. Circ J 76(5):1213-21.

4 Hong et al (2011) Telmisartan reduces neointima volume and pulse wave velocity 8 months after zotarolimus-eluting stent implantation in hypertensive type 2 diabetic patients. Heart 97(17):1425-32.

5 Hong et al (2010) Comparison of three-year clinical outcomes between sirolimus-versus paclitaxel-eluting stents in diabetic patients: prospective randomized multicenter trial. Catheter Cardiovasc Interv 76(7):924-33.

Stem cell therapy for cardiovascular diseases Elucidation of effi cient stem cell sources Development of cell differentiation methods & elucidation of mechanisms Effi cacy and safety of stem cells in animal models with heart diseases

Novel biomarkers and detection systems for early diagnosis of cardiovascular disease Elucidation of new blood biomarkers (miRNAs, chemokines, stem cells) in cardiac patients Development of biomarker detection system with high sensitivity Validation of biomarkers in cardiac patients

Research Interest



Laboratories 52 53

Lab of Gastrointestinal Cancer Biology

PI: Sang Cheul OH, M.D., Ph.D. Department of Biomedical Sciences, Division of oncology


SCO’s research focused on cancer biology. Specifi cally: 1)Cell motility, adhesion, metastasis 2)Cell cycle & Apoptosis 3)Cancer stem cell 4)Drug resistant 5)Clinicaltrials. Recently he is trying to fi nd some new bio-markers in gastric and colon cancer. We collaborate with department of surgery. So, we can use patient’s specimens included intestine and stomach. He is examining many clinical trials for target therapy. Our goal is to identify signaling pathway that can be used as targets in cancer therapy.

Suggest specifi c target chemo therapy to patient case by caseGOAL

1 Hematogenous metastasis of ovarian cancer: rethinking mode of spread. Cancer Cell. 2014 Jul 14;26(1):77-91

2 Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial. Lancet Oncol. 2013 May;14(6):490-9.

3 Prognostic gene expression signature associated with two molecularly distinct subtypes of colorectal cancer. Gut. 2012 Sep;61(9):1291-8.

4 Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 path-way in gastric cancer. Cancer Res. 2011 Nov 15;71(22):7061-70

5 Metastatic function of BMP-2 in gastric cancer cells: the role of PI3K/AKT, MAPK, the NF-κB pathway, and MMP-9 expression. Exp Cell Res. 2011 Jul 15;317(12):1746-62

Metastasis gene validation and Signaling pathway functional study Clinical data analysis

Research Interest


Hand Surgery & Reconstructive Microsurgery

PI: Jong Woong PARK, M.D., Ph.D. Department of Orthopaedic Surgery, Hand Surgery & Reconstructive Microsurgery


Prof. JW Park’s main research interests are in innovation of hand surgery, mechanism of neural regeneration, and hu-man-machine interface in the fi eld of bionics. More specifi cally, he has focused on the treatment strategy to enhance peripheral nerve regeneration through autogenous and synthetic nerve conduits and the cutting edge technology of hu-man-machine interface using various kinds of cutting edge technologies. He is also trying to develop new medical devices and to teach hand surgery and reconstructive microsurgery to young enthusiastic surgeons.

Enhancing Neural Regeneration & Innovation in Human-Machine InterfaceGOAL

1 JW P ark et al. (2014) The effect of platelet-rich plasma on peripheral nerve regeneration in a rat model. NRR.

1 JW Park (2014) Surgical Techniques for Repairing Foveal Tear of the Triangular Fibrocartilage Complex: Arthroscopic Transosseous Repair. JKSSH. 19(2): 95-102.

1 JI Lee, JW Park et al. (2013) Remote Postconditioning attenuate Ischemic-Reperfusion Injury in Rat Skeletal Muscle and Remote Postconditioning by ATP sensitive K Channel Dependent Mechanism. JRM. 9(29): 571-578.

1 AJ Lee, JW Park et al. (2013) Detection of Active Matrix Metalloroteinase-3 in Serum and Fibroblast-like Synoviocytes of Collagen-Induced Arthritis Mice. Bioconjugate Chemistry. 24(6): 1068-1074.

1 JH Ryu, JW Park et al. (2012) Measurement of MMP activity in synovial fl uid in cases of osteoarthritis and acute in-fl ammatory conditions of the knee joints using a fl uorogenic peptide probe-immobilized diagnostic kit. Theranostics. 2(2):198-206.

Strategy for enhancing nerve regeneration

Innovative technologies for human-machine interface in bionics

Development of medical devices & education of young surgeons

Research Interest



Laboratories 54 55

Cardiovascular Intervention and Research Institute

PI: Seung-Woon RHA, MD., PhD., FACC, FAHA, FESC Department of Internal Medicine, Korea University Cardiovascular Center, Korea University Guro Hospital

Contact Information E-mail: [email protected] Phone: +82 2 2626 3020 (Offi ce) / +82 10 8721 0459 (Mobile) Homepage: http://www.ciri.or.kr

1 Park JY, Rha SW, Poddar KL, et al. Impact of low-dose aspirin on coronary artery spasm as assessed by intracoronary acetylcholine provocation test in Korean patients. Journal of Cardiology 2012;60:187-91.

2 Chen KY, Rha SW, Wang L, et al. Unrestricted use of 2 new-generation drug-eluting stents in patients with acute myo-cardial infarction: a propensity score-matched analysis. JACC Cardiovascular Interventions 2012;5:936-45.

3 Choi CU, Rha SW, Jin Z, et al. The optimal timing for non-cardiac surgery after percutaneous coronary intervention with drug-eluting stents. International Journal of Cardiology 2010;139:313-6.

4 Chen KY, Rha SW, Li YJ, et al. Impact of hypertension on coronary artery spasm as assessed with intracoronary acetyl-choline provocation test. Journal of Human Hypertension 2010;24:77-85.

5 Chen KY, Rha SW, Li YJ, et al. Triple versus dual antiplatelet therapy in patients with acute ST-segment elevation myo-cardial infarction undergoing primary percutaneous coronary intervention. Circulation 2009;119:3207-14.

Research Interest


Cardiovascular Intervention and Research Institute (CIRI) aims to improve the quality of life for patients with car-diovascular disease. Since its foudation in 2012, we have focused on fi nding the most practical way to bring the lab closer to the patient’s care in the ongoing clinical re-searches based on global understanding. By independent analysis of numerous data and database management, we make the swift and decisive progress of developing the insights into risks and outcomes for patients after in-terventional procedures that makes ultimately important contribution to the area of interventional cardiovascular medicine. Followings are our main research fi elds.

1. Complex coronary intervention2. Complex peripheral intervention3. Coronary artery endothelial dysfunction and spasm4. Vascular disease combined with metabolic and endocrine disorder

Lab of Breast Cancer Targeting Drug

PI: Jae Hong SEO, M.D., Ph.D. Department of Medical Oncology


Professor Seo mainly interested in breast cancer targeted therapy and breast cancer stem cell research. Therefore, his lab-oratory has been performed research about development of new breast cancer targeting drugs and mechanism studies of breast cancer stem cell theory.

1 Association of a vascular endothelial growth factor (VEGF) gene 936 C/T polymorphism with breast cancer risk: a me-ta-analysis. Dae Sik Yang, Ok Hee Woo, Kyong Hwa Park, Sang Uk Woo, Ae-Ree Kim, Eun Sook Lee, Jae-Bok Lee, Yeul Hong Kim, Jun Suk Kim, Jae Hong Seo, Breast Cancer Res Treat, 125(3):849-853, 2011

2 Association of a TGF-β1 509 C/T polymorphism with breast cancer risk: a meta-analysis, Sang Uk Woo, Ok Hee Woo, Kyong Hwa Park, Dae Sik Yang, Ae-Ree Kim, Eun Sook Lee, Jae-Bok Lee, Yeul Hong Kim, Jun Suk Kim, Jae Hong Seo, Breast Cancer Res Treat, 124(2):481-5, 2010

3 Sustained co-cultivation with human placenta-derived MSCs enhance ALK5/Smad3 signaling in human breast epithelial cells, leading to EMT and differentiation, Young A Yoo, Myung Hee Kang, Byung Soo Kim, Jun Suk Kim, Jae Hong Seo, Differentiation 77(5):450-461, 2009

4 Docetaxel and epirubicin salvage regimen in anthracycline sensitive metastatic breast cancer patients relapsed after anthracycline-containing adjuvant therapy, Jae Hong Seo, Hwa Jung Sung, In Keun Choi, Sang Cheul Oh, Yeul Hong Kim, Jun Suk Kim, Ae-Ree Kim, Jae-Bok Lee, Bum Hwan Koo Investigational New Drugs Vol 27(1):67-73, 2009

5 Functional implication of Akt Activity and TGF-β signaling in Tamoxifen-resistanct Breast Cancer, Young A Yoo, Yeul Hong Kim, Jun Suk Kim, Jae Hong Seo BBA-Mol Cell Res Vol 1783(3):438-447, 2008

Aptamer based targeted therapy Aptamer based targeted therapy Disulfi ram/Cu: cancer stem cell

Research Interest

Featured Publications Appendix 01 Faculty &

Laboratories 56 57

Lab of Dental Research

PI: Sang Wan SHIN, DDS, PhD Department of Biomedical Sciences

Contact Information E-mail: [email protected] Tel: +82 2 2626 1922 (Offi ce) / +82 2 2626 2489 (Lab) Homepage: http://www.icdr.kr/

SWS is interested in promotion of dental science and patients’ quality of life through basic and clinical researches, and various biomedical, engineering, and clinical evaluations are being researched to prove the safety and effectiveness of dental devices and materials. This lab for clinical application fi nally is focusing a central role of collaboration researches between researcher, industry, and hospital.

Development of dental devices and materialsGOAL

1 Shin SW et al (2014) Ridge preservation using demineralized bone matrix gel with recombinant human bone morphoge-netic protein-2 after tooth extraction: a randomized controlled clinical trial. J Oral Maxillofac Surg 2014 Jul;72(7):1281-90.

2 Shin SW et al (2014) Infl uence of Implant transmucosal design on early peri-implant tissue responses in beagle dogs. Clin Oral Implants Res 2014 Aug;25(8):962-8.

3 Shin SW et al (2013) Altered sensation caused by peri-implantitis: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol 2013 Jul;116(1):e9-13.

4 Shin SW et al (2013) Effect of span length on the fi t of zirconia framework fabricated using CAD/CAM system. J Adv Prosthodont 2013 May;5(2):118-25.

5 Shin SW et al (2013) Physical stability of arginine-glycine-aspartic acid peptide coated on anodized implants after instal-lation. J Adv Prosthodont 2013 May;5(2):84-91.

Randomized Clinical Trial of Implant Overdentures Retrospective Clinical Studies on the Longevity of Implant Guided Bone Regeneration (GBR)

in vitro study of Osteoblastic activity; Cell adhesion, Cell proliferation in vivo study of Bone Regenerative Capacity

Research on Digital Dentistry (Dental device and CAD/CAM) Engineering test on dental implants and various dental materials; metal, ceramics, polymer, etc.

Research Interest


Clinical Research Cell Biology & Animal Experiments Engineering Test of Dental Devices and Materials

Lab of Cell Signaling and Nanomedicine

PI: Sang Wook SON, M.D., Ph.D. Department of Dermatology


Professor Son is interested in the pathogenesis of infl ammatory skin diseases, particularly, psoriasis and atopic dermatitis, and infl uences of environmental factors (UV, cigarette and nanometerials) in the skin. He is studying for regulatory mole-cules of skin barrier, nanomedicine and signaling pathways.

Development of drug for the treatment of skin diseaseGOAL

1 Jung et al. (2014) Silver Nanoparticle-Induced hMSC Proliferation is Associated with HIF-1α-Mediated Upregulation of IL-8 Expression. J Invest Dermatol.

2 Jang et al. (2013) UVB induces HIF-1α-dependent TSLP expression via the JNK and ERK pathways. J Invest Dermatol. 133:2601.

3 Jeong et al. (2013) ZnO nanoparticles induce TNF-α expression via ROS-ERK-Egr-1 pathway in human keratinocytes. J Dermatol Sci. 72:263.

4 Kim et al. (2011) Cigarette smoke-induced early growth response-1 regulates the expression of the cysteine-rich 61 in human skin dermal fi broblasts. Exp Dermatol 20:992.

5 Kim et al. (2009) Up-regulation of TNF-alpha secretion by cigarette smoke is mediated by Egr-1 in HaCaT human kerati-nocytes. Exp Dermatol 19:e206.

Research Interest


Pathogenesis of infl ammatory skin disease Atopic dermatitis Psoriasis

Infl uence of environmental factor in skin UV VOCs Cigarette Nanomaterials

Evaluation of drug candiate for the treatemnt of skin disease


Laboratories 58 59

Lab of Bone Defect/Disease Fusion-Therapy Center

PI: Hae-Ryong SONG, M.D., Ph.D. Department of Orthopedics Department of Biomedical Sciences

Contact Information E-mail: [email protected] Tel: +82 2 2626 2483 (Offi ce) / +82 2 2626 1927 (Lab) Homepage: http://www.kumcbone.or.kr

The Bone Defect/Disease Fusion-Therapy Center, it will develop new-generation bone defect/disease medicine and build a pipeline for products with high possibility for commercialization. As well as it will progress innovative products’ technol-ogy transfer and commercialization.

Development of Bone Defect/Disease TreatmentGOAL

1 Song et al. (2014) Bone Formation in a Rat Tibial Defect Model Using Carboxymethyl Cellulose/BioC/Bone Morphogenic Protein-2 Hybrid Materials. BiodMed Research Internationl.

2 Yun et al. (2014) The effect of alendronate-loaded polycarprolactone nanofi brous scaffolds on osteogenic differentiation of adipose-derived stem cells in bone tissue regeneration. J biomed Nanotechnol; 10(6):1080-90.

3 Kim et al. (2014) In vitro and in vivo evaluation of bone formation using solid freefrom fabrication-based bon morphogenic protein-2 releasing PCL/PLGA scaffold. Biomed Mast; 9(2): 025008.

4 Lee et al. (2013) The effect of titanium with heparin/BMP-2 complex for improving osteoblast activity. Carbohydrate Poly-mer 98: 546-554

5 Kim et al. (2013) Bone formation of middle ear cavity using biphasic calcium phosphate lyophilized with Esherichia coli-de-rived recombinant human bone morphogenetic protein 2 usig animal model. International Journal of Pediatric Otorhino-laryngology 77: 1430-1433

Development of patient specifi c 3D artifi cial scaffold depending on the form of fracture and osteomyelitis

Gentamicin sulfate and BMP-2 loaded implant development

BMP-2 coated 3-dimentional artifi cial scaffolds animal testing

Research Interest


Lab of Diabetes & Atherosclerosis

PI: Hye Jin YOO, M.D., Ph.D. Department of Endocrinology and Metabolism

Contact Information E-mail: [email protected] Tel: +82 2 2626 3045 (Offi ce)

HJY’s main research interests are in clarifying the underlying molecular mechanisms interconnecting diabetes and ath-erosclerosis. In detail, she has focused on the function of adipose tissue derived various adipokines on the development of atherosclerosis, mainly in the environment of endothelial cells. Her main targeting pathway are infl ammatory and ER stress pathways via AMPK, NF-κb, JNK signaling and so on. She also manages human clinical cohort with type 2 diabetes for “the bench to the clinic”.

Understanding the Molecular Mechanism mediating between diabetes and atherosclerosis

GOAL

1 Hwang et al. (2014) Dipeptidyl petidase-IV inhibitor (gemigliptin) inhibits tunicamycin-induced endoplasmic reticulum stress, apoptosis and infl ammation in H9c2 cardiomyocytes. Mol Cell Endocrinol. 392(1-2):1-7

2 Yoo et al. (2014) Association of metabolically abnormal but normal weight (MANW) and metabolically healthy but obese (MHO) individuals with arterial stiffness and carotid atherosclerosis. Atherosclerosis. 234(1):218-23.

3 Hwang et al. (2013) Progranulin protects vascular endothelium against atherosclerotic infl ammatory reaction via Akt/eNOS and nuclear factor-κB pathways. PLoS One 8(9):e76679.

4 Yoo et al. (2013) Association of glypican-4 with body fat distribution, insulin resistance, and nonalcoholic Fatty liver disease J Clin Endocrinol Metab. 98(7):2897-901.

5 Yoo et al. (2013) Implication of progranulin and C1q/TNF-related protein-3 (CTRP3) on infl ammation and atherosclerosis in subjects with or without metabolic syndrome. PLoS One. 8(2):e55744

Research Interest



Laboratories 60 61

Lab of Diagnostic Technology Development

PI : Soo-Young YOON, M.D., Ph.D. Department of Laboratory Medicine


Professor Yoon is interested in diagnostic biomarker, diagnostic technology and diagnostic device. She is searching for novel biomarker of hematologic malignancy in order to overcome current diagnostic limitation. She is striving to intro-duce and apply the latest diagnostic technology, verifying diagnostic accuracy and effi cacy before clinical laboratory implementation for patients with cancer, cardiovascular disease, and chronic infl ammatory disease. She is also evaluating performance of diagnostic device recently developed for diagnosis of cardiovascular disease and diabetes.

Development of high sensitive diagnostic sensing systemGOAL

1 Chon et al. (2014) SERS-based competitive immunoassay of troponin I and CK-MB markers for early diagnosis of acute myocardial infarction. Chem Commun. 50(9):1058-60.

2 Lee et al. (2014) Prediction of Antiarthritic Drug Effi cacies by Monitoring Active Matrix Metalloproteinase-3 (MMP-3) Levels in Collagen-Induced Arthritic. Mol Pharm. 11(5):1450-8.

3 Ko et al. (2013) SERS-based immunoassay of tumor marker VEGF using DNA aptamers and silica-encapsulated hollow gold nanospheres. Phys Chem Chem Phys. 15(15):5379-85.

4 Park et al. (2012) Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy. Adv Mater. 24(42):5755-61.

5 Chon et al. (2011) Simultaneous immunoassay for the detection of two lung cancer markers using functionalized SERS nanoprobes. Chem Commun. 47(46):12515-7.

Novel biomarker searching study Profi ling specifi c biomarker to hematologic malignancy Bioinformatics to defi ne disease specifi c biomarker

Introduction of the latest diagnostic technology Applying Integrated Human Sensing System to laboratory diagnostic tests Verifi cation of diagnostic accuracy and effi cacy

Evaluation of diagnostic device Developing diagnostic device Clinical trials evaluating Troponin I, CK-MB, Myoglobin, HbA1c detection kit

Research Interest



Laboratories 62 63

Department of Biomedical Sciences

Curriculum02Appendix

Academic GoalsBiomedical Science aims to protect humans from diseases and supports well-being of human life. To accomplish this goal, biomedical

science broadly covers basic and applied research to understand mechanisms of pathogenesis and to fi nd novel methods for preventive,

diagnostic, and therapeutic treatment. Biomedical science, in particular, is a typical fusion-science, composed of many disciplines from

biology, pharmacology, physics, chemistry, engineering, bioinformatics, nanosciences, and social sciences. The importance of biomedi-

cal science is increasing with social demands. Accordingly need for experts is expanding and specialized training systems are becoming

necessary to train leading experts in the biomedical sciences.

The mission of the Department of Biomedical Sciences in the Korea University Graduate Program is to nurture future leading biomedical

researchers through the provision of relevant, up-to-date biomedical knowledge, the support of student’s independent research activi-

ties, and the facilitation of student-professor and student-student collaboration.

Fields of StudyCourse of Biomedical Science is comprised of two majors as follows:

Biomedical Science


Degree Requirements1 Students who are enrolled in master’s degree programs must receive a total of 24 “”course work”” credits or more, including 6 credits

for core subjects, more than 6 credits for major subjects, more than 6 credits for elective subjects, and 6 credits for BM biomedical

seminars.

2 Students who are enrolled in doctoral degree programs must receive a total of 36 “”course work”” credits or more, including 9 credits

for core subjects, at least 9 credits for major subjects, at least 9 credits for elective subjects, 3 credits for BM foundation of biomedical

research, and 6 credits for biomedical seminars. The subjects completed during master’s degree program should be excluded. There

is no discrimination between master’s degree and doctoral degree programs in terms of subjects.

3 Students who are enrolled in integrated master’s and doctoral degree program must receive a total of 54 “”course work”” credits or

more, including 12 credits for core subjects, at least 15 credits for major subjects, at least 15 credits for elective subjects, 3 credits for

BM foundation of biomedical research, and 9 credits for biomedical seminars.”

Comprehensive Examinations1 Master degree program in the Department of Biomedical Sciences: Students are examined on 1 core and 1 major subject.

2 Doctoral degree program in the Department of Biomedical Sciences: Students are examined on 1 major and 1 elective subject.

3 Integrated master and doctoral degree program in the Department of Biomedical Sciences: Students are examined on 1 major and 1

elective subject.

Appendix 02 Curriculum

64 65

Code Course Syllabus Credits

BMS 501

의과학 인체생리학

BM Human PhysiologyThe objective of this course is to provide information on the mechanisms and physiological functions of the human body.

[3]

BMS 503

의과학 분자세포생물학

Molecular and Cell BiologyThe objective of this course is to provide understanding of introductory level cell biology, molecular biology, and biochemistry. This course will cover signal transduction and control mechanisms which are involved in complex and combined cell states such as structure and function of cellular and biological molecules, energy production, enzyme epidemiology, mechanism and control, structure and function of cellular membranes, and structure, func-tion and differentiation of cells. Also, this course will deal with cellular compartmental-ization, movement of macro-molecules, biogenesis of organelles, cell differentiation, cell movement, and cell conjunction.

[3]

BMS 504

의과학 임상의학 개론

BM Introduction to Clinical MedicineThe aim of this course is to provide an introduction to clinical symptoms, diagnoses and therapies for various diseases. Also, an objective of this course is to structurally understand diseases by understanding their etiology.

[3]

BMS 505

의과학 최신의학세미나 I

BM Biomedical Seminars IThis course will provide knowledge from a wide variety of major subjects by providing sem-inars of up-to-date research trends which are lectured by experts.

[3]

BMS 506

의과학 최신의학세미나 II

BM Biomedical Seminars IIThis course will provide knowledge from a wide variety of major subjects by providing sem-inars of up-to-date research trends which are lectured by experts.

[3]

BMS 507

의과학 최신의학세미나 III

BM Biomedical Seminars IIIThis course will provide knowledge from a wide variety of major subjects by providing sem-inars of up-to-date research trends which are lectured by experts.

[3]

BMS 508

의과학 최신의학세미나IV

BM Biomedical Seminars IVThis course will provide knowledge from a wide variety of major subjects by providing sem-inars of up-to-date research trends which are lectured by experts.

[3]

BMS 509

의과학 연구의 기초

BM Foundation of Biomedical ResearchThis course introduces guidelines for safe laboratory procedures and ethics for research and laboratory animals, which are the basis of good biomedical research work.

[3]

BMS 510

의과학 고급분자세포생물학

BM Advanced Molecular and Cell BiologyThe objective of this course is to study current important topics of molecular and cell biology. [3]

BMS 511

의과학 의용생체공학개론

BM Introduction to Biomedical EngineeringThe aim of this lecture is to learn about various technologies based on engineering for biomedical research. In this lecture, major topics of biomedical engineering such as medical devices, artificial organs, signal processing and tissue regeneration will be reviewed. Current research status and issues will be discussed.

[3]

BMS 527

의과학 인체해부학

BM Human AnatomyThe objective of this course is to provide understanding of structure-function relationships of cells, tissues, and organs and to apply interpreted signs and symptoms in human diseases and injuries.

[3]

BMS 528

오믹스융합의과학

BM Omics Convergence Biomedical TechnologyThe objective of this class is to understand the state-of-the-art technologies in the field of biomedical research with special emphasis on the Omics techniques.

[3]

BMS 529

의과학산업학

BM Biomedical industryThe objective of this class is to provide basic knowledge on biomedical R&D and how to transfer research findings into industry application.

[3]

BMS 530

중개연구총론

BM Introduction to Translational MedicineThe aim of this lecture is to learn about basic concepts comprising translational approaches from views of medicine and basic sciences, and to introduce practical links between the two to accelerate development of therapeutics.

[3]

BMS 531

의과학 최신의생명과학

BM Introduction to Molecular and Cell BiologyThe objective of this class is to understand the biological bases of cellular functions at a molecular level.

[3]

BMS 532

의과학 인체해부생리학

BM Introduction to human structure and functionThe objective of the class is to introduce the structure and function of the human body, including basic concepts in human anatomy and physiology.

[3]

BMS 639

의과학 의학물리

BM Medical PhysicsThe objective of this course is to provide understanding of models of human body phenom-ena based on physical knowledge. Studying physics provides understanding of the mecha-nisms of action of medicine and related phenomena.

[3]

Core Courses


BMS 512

의과학 연구실험기법

BM Laboratory MethodsThe objective of this course is to study diagnostic procedures from clinical diagnoses to labo-ratory experiments.

[3]

BMS 605

의과학 신경내분비학

BM NeuroendocrinologyThe objective of this course is to study the function of the hypothalamus as an endocrine-reg-ulatory center focused on anatomy, biochemistry, and physiology.

[3]

BMS 606

의과학 신경계질환

BM Diseases in the nervous systemThe objective of this course is to understand the mechanism of molecular cell interaction and search for new therapy-techniques.

[3]

BMS 615

의과학 고급 신경생물학 I

BM Advanced Neurobiology IThe objective of this course is to provide understanding of the complex structures and various functions of the nervous system by using morphological and molecular biological methods.

[3]

BMS 616

의과학 고급 신경생물학 II

BM Advanced Neurobiology IIThe objective of this subject is to understand research trends through study and discussion about complex structures and various functions.

[3]

BMS 619

의과학 세포막 수용체와 신호전달

BM Membrane receptors and signal transductionThis course discusses membrane receptors, in particular, G protein coupled receptors, with regard to their structure, ligand binding, and signaling mechanisms.

[3]

BMS 621

의과학 줄기세포론

BM Stem Cell BiologyThis course is designed to provide understanding of the current trends of embryonic stem cells, adult stem cells and iPS cells, and give insights into the clinical use of stem cells.

[3]

BMS 646

의과학 고급분자미생물학

BM Advanced Molecular MicrobiologyDevelopment of molecular biological methods leads to changes in our understanding of mi-crobiology. Continuous gene evolution and variation is essential to life. The objective of this course is to study microbiology, focusing on molecular biology.

[3]

BMS 655

의과학 일반 면역학 Ⅰ

BM General ImmunologyThe objective of this course is to provide understanding of the basic knowledge regarding composition, functions, development and differentiation of the immune system, in addition to cooperative interaction of immune cells.

[3]

BMS 656

의과학 일반 면역학 Ⅱ

BM General ImmunologyThe objective of this course is to provide understanding of the medical and biological appli-cations of basic immunological concepts, especially regarding body protection mechanisms.

[3]

BMS 657

의과학 시스템생물학

BM Systems BiologyRecent developments in genomics and new sequencing technology have lead researchers to understand the life as systematic networks of genomic information and constituent mole-cules. Such systems-biology research is expected to help unveil the complex interactions be-tween pathogens and humans, and thereby will lead to the development of better means of disease prevention and treatments in the future. This class will discuss the principles, the birth, and the future direction of systems biology, which is still new but will take a center stage in the future life science and medical technology.

[3]

BMS 659

의과학 암발생학

BM CarcinogenesisIn this course, students will research the interaction and causes of carcinogenesis and provide an introduction to cancer prevention and therapy.

[3]

BMS 683

의과학 인간질환의 구조학적 접근

BM Structural Basis of Human DiseasesThis course will deal with clinical symptoms, diagnoses, and therapies of various diseases. The objective is to provide understanding of disease development by focusing on anatomical and cellular knowledge and supposed hypotheses.

[3]

BMS 687

의과학 정보전달계

BM Signal TransductionThis course focuses on the intracellular signal transduction evoked by extracellular stimulations under physiological and pathological conditions.

[3]

BMS 688

의과학 생명과학개론

BM Principle of lifeThis course focuses on a series of essential biological content including biochemistry, genetics, physiology and cell biology and the research that led to our understanding of them through lectures and discussion.

[3]

BMS 690

의과학 종양생물학

BM Tumor BiologyThis course will deal with concepts of cancer cell characteristics, metastasis, cancer associated chemical substances, radiation & infection, cancer genetics, oncogenes, and tumor suppressor genes. And on the basis of this basic knowledge, we will try to apply clinical problems. Finally, this subject will supply theoretical background about tumor biology.

[3]

Major Courses Biomedical Science


66 67


BMS 625

의과학 의공 피부과학

BM Dermatology for BioengineeringThis course will cover basic concepts which are essential to bioengineering research and examine how to apply bioengineering results.

[3]

BMS 626

의과학 생체 표면학

BM Biomedical MetrologyThis course will provide theory and practice of research about diagnosis of disease, severity of dis-ease, and adjustment of therapy by using analysis of surface characteristics in various human organs.

[3]

BMS 627

의과학 의생명 현미경학

BM Biomedical MicroscopyThe objective of this course is to provide understanding of the principles, characteristics and limits of various microscope equipment designed to view micro-structures of an organism. This course will also cover basic theories and practice for constructing observation techniques.

[3]

BMS 628

의과학 고급 영상 분석학

BM Advanced Image AnalysisThis course will provide lectures about various techniques and theories to analyze complex and spe-cialized images.

[3]

BMS 629

의과학 영상 분석학 기초

BM Basic Image AnalysisThis course will deal with a variety of basic theories and image-analysis techniques to analyze images. [3]

BMS 630

의과학 약물전달체계

BM Drug Delivery SystemThe objective of this course is to provide understanding of organ materials and various drug delivery systems used for drug delivery. Also, this course will examine example applications of various drug delivery systems.

[3]

BMS 631

의과학 의공학 주제연구 I

BM Topics in Biomedical Engineering IThis course will provide discussion-lectures about up-to-date subjects related to trends in biomedical engineering.

[3]

BMS 632

의과학 의공학 주제연구 II

BM Topics in Biomedical Engineering IIThis course will provide discussion-lectures about up-to-date subjects related to trends in biomedical engineering.

[3]

BMS 633

의과학 인공장기학

BM Artificial OrgansThe objective of this course is to study the structure and principle functions of artificial organs and membranes, in particular those used in the cardiovascular system. The course will also cover potential problems, safety and convenience according to human applications of these artificial organs.

[3]

BMS 634

의과학 고분자 생체재료학

BM Polymers in BiomaterialsThis course will cover polymers in biomaterials: their physical and chemical characteristics, necessary conditions and their reactions in the human body as implants. Also, this subject will study the physi-ological and biodynamical characteristics of soft tissue implants and the design methods of polymers in biomaterials.

[3]

BMS 635

의과학 조직 및 세포공학

BM Tissue and Cellular EngineeringThis course will deal with tissue engineering approaches for the displacement of impaired tissue in blood vessels, nerves, skin, and cartilage. The objective of this course will be to study the use of three-dimensional polymeric scaffolds, drug delivery carriers, gene therapy, and cellular engineering approaches as methods for function recovery of impaired tissue.

[3]

BMS 636

의과학 생체재료와 생체적합성

BM Biomaterials and BiocompatibilityThis course will check applications of biomaterials on various tissues and organs and deal with reac-tions of the human body according to physical and chemical characteristics of each material. Also, this subject will provide methods of selection, creation, and changes in material for human body application.

[3]

BMS 637

의과학 나노 생체재료

BM Nano-biomaterialsThe objective of this course is to understand nano-processing techniques and special analysis meth-ods, as well as their reactions in the human body. It will cover the use of nano-technology to im-prove the functions of and overcome the limits of traditional biomaterials and biomedical synthesis techniques.

[3]

BMS 638

의과학 나노 의료기술 특론

BM Topics on Nano-medical TechnologyThis course will deal with current and future techniques in nano-technology used for medical diag-nosis and therapy. Specifically, it will focus on nano-particles, nano-sensors and nano-biochips used in early diagnosis and nano- technology used for drug delivery.

[3]

BMS 640

의과학 인공심장 특강

BM Artificial HeartThe objective of this course is to study definition, principles, and control of artificial hearts. This course will deal with merits and faults of artificial hearts by analysing various case studies.

[3]

BMS 641

의과학 비침습의공학

BM non-invasive bioengineeringIn this course, students will learn to diagnose and proscribe therapies for diseases resulting from noninvasive access methods.

[3]

BMS 642

의과학 화학영상 진단학

BM chemical imaging for medical diagnosisThis course will provide an overview of technology for diagnosis and therapy using chemical medi-cine, and its use in the imaging of tissue function and metabolism.

[3]

BMS 643

의과학 의료기기학

BM Technology for the Medical DeviceThis class provides education on basic concepts and state-of-the-art medical devices leading to un-derstanding of the engineering aspects of clinical medicine and developing perspectives in interdis-ciplinary approaches.

[3]

BMS 644

의과학 바이오 칩 개론

BM Introduction of Biochip This class deals with concepts, current status, and applications of various biochips including DNA chips, protein chips, lab-on-a-chips, etc., that are widely utilized in biotechnology and clinical med-icine.

[3]

BMS 645

의과학 분자생물 전자특론

BM Biology for EngineersThis class is an introduction to biology for students with engineering backgrounds other than biology or related fields to develop basic understanding in biology for biomedical research.

[3]

BMS 692

의과학 방사선치료물리학

BM Radiation Treatment PhysicsThis course will introduce and discuss radiation therapy equipments and study physical theories and characteristics of these devices to develop the ability to optimally use these equipments in a clinical environment.

[3]

BMS 694

의과학 의학물리 세미나

BM Seminars in Medical PhysicsSeminars in medical physics will invite famous experts in medical physics to give lectures about new trends in ongoing clinical applications and research, and to develop insights into basic research and clinical applications.

[3]



BMS 513

의과학 미생물학 및 면역학

BM Microbiology and ImmunologyThe objective of this course is to provide understanding of basic concepts of microbiology and immu-nology, such as basic structures of antibodies/antigens and mechanisms of interaction between cells and their factors.

[3]

BMS 514

의과학 의생명 과학정보

BM Biomedical InfomaticsThe aim of these lectures is to study novel biomedical hypotheses and etiologies through searching databases and mining up-to-date information on biomedical research.

[3]

BMS 515

의과학 기초병리학 개론

BM Basic PathologyThe objective of this subject is to provide understanding of the basic concepts, causes, and characters of human diseases.

[3]

BMS 516

의과학 고급면역학

BM Advanced ImmunologyTo enhance the understanding of basic theory and practical application in immunology, the application and preparation in antibody therapeutics, vaccine preparation, immune cellular therapy, transplantation and hypersensitivity is lectured.

[3]

BMS 517

의과학 의생물학 연구 방법론

BM Research Methodology for Biomedical Science

The objective of this subject is to study modern research methodology related to biomedical science. [3]

BMS 518

의과학 발생학개론

BM Principles of Developmental BiologyThis course will provide principles and key concepts for developmental biology. It will cover the process by which genes in fertilized eggs control cell behavior in the embryo and so determine its pattern, its form, and much of its behavior.

[3]

BMS 519

의과학 최신 의생명과학

BM Emerging medical biologyIn this course, students will learn about recent achievements in medical biology regarding new findings of mechanisms of development of human diseases and their prevention and therapeutics.

[3]

BMS 520

의과학 병태생리와 약리학

BM Pathophysiology and PharmacologyStudents will investigate and understand the principles and mechanisms of drug action on the basis of pathophysiology, which is the changes of physiological and biochemical functions caused by human diseases.

[3]

BMS 521

의과학 바이러스학 원론

BM Principles of VirologyThe objective of this course is to understand basic concepts and theories of virology. Correct facts for common misunderstandings and interpretations of problems for current important topics will be provided.

[3]

BMS 522

의과학 신약개발특론

BM Advanced drug discovery and development

To understand the essential requisites of biologically-active chemicals for new drug discovery, and to study toxicological examinations and techniques in drug development

[3]

BMS 523

의과학 제제학특론

BM Advanced PharmaceuticsTo learn formulations and manufacturing processes of conventional, target-oriented and/or controlled drug delivery, and to study pharmaceutical methods enhancing drug efficacy.

[3]

BMS 524

의과학 논문발표세미나

BM Work-In Progress SeminarStudents who take this course will present the progress in their thesis studies and take

the interim feedbacks from the others that have diverse scientific background under the

guidance of the lecturers.

[3]

BMS 525

의과학 생화학 특론 I

BM Advanced Biochemistry IThe objective of this lecture is to provide understanding of metabolism and cover current knowledge of biochemical techniques.

3]

BMS 526

의과학 생화학 특론 II

BM Advanced Biochemistry IIThe objective of this lecture is to provide understanding of metabolism and cover current knowledge of biochemical techniques.

[3]

BMS 601

의과학 신경생리학

BM NeurophysiologyThis course is designed to study the structure of the nervous system and its function. It will cover nerves, synapses, reflex circuits, sensory systems, and kinetic systems.

[3]

BMS 602

의과학 신경약리학

BM NeuropharmacologyThis course will deal with drugs such as anti-depressant drugs, anaesthetic agents, and somnifacient and antiseizure drugs.

[3]

BMS 603

의과학 자율신경계

BM Autonomic Nervous SystemThis course is designed to study the structure of the autonomic nervous system and central control func-tions of the cardiovascular and respiration systems, and metabolism of diet, water intake and body fluid.

[3]

BMS 604

의과학 분자세포신경생물학

BM Molecular NeurobiologyThe aim of this course is to study the functions, developments and control mechanisms of the nerve cells at molecular and gene levels.

[3]

BMS 607

의과학 신경정신약리학

BM NeuropsychopharmacologyLectures will be addressed to understand the actions and mechanisms of drugs in neurological and psychiatric disease based on recent advances in basic neuroscience.

[3]

BMS 608

의과학 노화의 유전학 모델

BM Genetic Models in AgingBased on studies of genetically manipulated animal models, ageing processes are analyzed. We try to understand the concepts and methods used to generate model animals and to search for ways to devel-op more advanced model animals for ageing studies.

[3]

BMS 609

의과학 질병과 초파리 유전학

BM Drosophila Genetics in Human DiseasesIn order to understand human life and diseases, mechanisms controlled by genes are studied in Drosoph-ila melanogaster. Also, the resources of Drosophila genetics will be provided to apply proper models for human diseases.

[3]

BMS 610

의과학 신경과학 주제연구

BM Topics in NeuroscienceThese discussion-lectures will deal with subjects related to the current progress in neuroscience. [3]

BMS 611

의과학 신경과학 세미나

BM Seminars in NeuroscienceThis seminar provides a forum for discussion of the up-to-date trends in neuroscience. Seminar topics will be led by guest speakers.

[3]

Elective Courses


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BMS 612

의과학 신경과학의 원리

BM Principles of Neural ScienceThe aim of this lecture is to cover the basic information and principles that govern functions of the nervous system.

[3]

BMS 613

의과학 유전자치료학 개론

BM Concepts of Cancer Gene TherapyThis course is designed to provide definition and concepts of gene and oncogene therapy, especially current gene therapy and clinical application.

[3]

BMS 614

의과학 생명공학윤리

BM Ethics of Medical BiotechnologyThis course will provide basic concepts and ethic consciousness for development and prosperity of biotechnology, especially medical biotechnology for clinical therapy. This will be done through lec-tures by expert of biotechnology, law, and religion.

[3]

BMS 617

의과학 발달 유전학 I

BM Developmental Genetics IThis course will provide understanding of genetic regulation of individual development, from fer-tilized eggs to individuals with complex structures, through morphological and molecular biologic methods.

[3]

BMS 618

의과학 발달 유전학 II

BM Developmental Genetics IIThis course is designed to teach current trends in developmental genetics, through discussion and study of current research and processes of genetic control in individual development. Various clinical genetic diseases will be studied at a molecular level based on knowledge from genetics, molecular biology, and biochemistry.

[3]

BMS 620

의과학 분자 신경내분비학

BM Molecular NeuroendocrinologyThis course covers hypothalamic control of neuroendocrine functions including reproduction, growth, homeostasis, biological rhythm, sleep and appetites from molecular biological aspects.

[3]

BMS 622

의과학 분자 발생생물학

BM Molecular Developmental BiologyThis course will cover the molecular mechanisms of early development such as fertilization, cleavage, gastrulation and organ development.

[3]

BMS 623

의과학 전사인자

BM transcription factorsThe purpose of this course is to acquire the fundamental knowledge on regulation of gene ex-pression by introducing transcription factors, regulation of transcription and methods for studying transcription factors.

[3]

BMS 624

의과학 신호전달 분자 네트워크

BM Molecular networks in signal transduction

This course deals with understanding molecular interactions in intracellular signaling pathways caused by extracellular stimulations, and the effect of change at the level of genome or protein on molecular networks and cellular responses.

[3]

BMS 647

의과학 분자세균학

BM Molecular BacteriologyThis course will cover structure, proliferation, and mutation of bacteria and an introduction to bac-terial genetics.

[3]

BMS 648

의과학 최신 의학바이러스학

BM Emerging Medical VirologyIn this course, students will learn about molecular biology, gene structure and character, gene system analysis, and prevention of virus infection.

[3]

BMS 649

의과학 고급 면역학 I

BM Advanced Immunology IThis course will deal with genetic immunology, cellular immunology, and chemical immunology. [3]

BMS 650

의과학 고급 면역학 II

BM Advanced Immunology IIThis course will cover autoimmune disease, tumor immunology, and allergy. [3]

BMS 651

의과학 종양바이러스학

BM Oncogenic VirologyThis course will cover viruses related to tumors, interaction among host cells, gene character, struc-ture and proliferation, DNA tumor viruses and RNA tumor viruses, oncogenes, papilloma virus, hep-atitis virus and Human T-cell leukemia virus.

[3]

BMS 652

의과학 면역질환 연구

BM Research of Immune related diseaseThis course will set research plans and cover experiment plans, practice, and data analysis of immune diseases.

[3]

BMS 653

의과학 감염증에 대한 선천면역

BM Innate Immune Response to InfectionThe object of this course is to provide understanding of recent advances in the innate immune sys-tem, particularly the complex web of first-response molecules that it is composed of. It addresses the basis of the innate immune response in humans, including the biology of neutrophils, the stage for an insightful examination of microbicidal pathways, and function and overlap of receptor activities.

[3]

BMS 654

의과학 유전자백신의 전략

BM Strategies of Genetic VaccineThe objective of this course is to study induced mechanisms by genetic vaccination of various forms in living things, and strategies for increasing immune reaction.

[3]

BMS 658

의과학 종양 분자생물학

BM Oncogene Molecular BiologyThis course will discuss oncogenes, including the molecular biological metabolisms that result in oncogene tumors and the change of signal transduction systems and controls.

[3]

BMS 660

의과학 암치료학

BM Cancer TreatmentThis course will cover development and application of cancer therapies such as immune therapy, gene therapy, new drug development, differentiation-induction therapy, development of new drug delivery methods, and various merger therapies.

[3]

BMS 661

의과학 암예방학

BM Cancer PreventionThis course will deal with the causes of cancer and methods and drugs used to block carcinogenesis. [3]

BMS 662

의과학 소화기 종양학

BM Gastrointestinal OncologyThe objective of this course is to understand the causes and metabolism of cancers of the digestive tract, liver, pancreas, and biliary tract. The course will cover pathology according to its metabolism, and development and application of research technology.

[3]

BMS 663

의과학 호흡기 종양학

BM Pulmonary OncologyThe objective of this course is to understand the causes and metabolism of cancer in the respiration and chest systems. This course will cover pathology according to metabolism, and development and application of research technology.

[3]

BMS 664

의과학 분자생물학 특론

BM Advanced Molecular BiologyThe aim of this course is to provide students with information about molecular biology. [3]


BMS 665

의과학 종양 면역학

BM Tumor ImmunologyIn this course, the interaction between tumors and host immune systems will be investigated from the perspective of systemic views including molecular, cellular, and systemic biology.

[3]

BMS 666

의과학 암 역학 및 예방

BM Cancer Epidemiology & PreventionThe overall objective of the course is to provide instruction in the principles and practice of cancer epidemiology and prevention. The course focuses on the epidemiologic concepts, methods, issues, and applications related to this field. Students have the opportunity to gain a broad-based perspec-tive of study design and risk factors for cancer, such as smoking, alcohol consumption, diet, physical exercise, and occupational factors.

[3]

BMS 667

의과학 최신 암유전자학

BM Emerging Molecular OncologyThe aim of this course is to provide students with recent information about molecular biology of cancer and to help students to write scientific papers.

[3]

BMS 668

의과학 항암내성

BM Resistance of Tumor Cells to Therapeutics

In this course, molecular biological mechanisms on the acquisition of tumor cell resistance to various anti-tumor modality such as chemotherapy, radiotherapy, immunotherapy, and gene therapy etc. will be addressed.

[3]

BMS 669

의과학 종양줄기세포생물학

BM Cancer Stem Cell BiologyThe objective of this course is to understand the characteristics of cancer stem cells, the origin of cancer cells, and the intrinsic resistance of cancer cells on the basis of cancer stem cell hypothesis. In this subject, a clinical applicability of novel approaches targeting cancer stem cells will be also investigated.

[3]

BMS 670

의과학 종양 분자생물학 연구 기법

BM Principles and techniques of molecular biology of cancer

The aim of this course is to provide students with the principles and techniques of the molecular biology of cancer.

BMS 671

의과학 항암분자치료

BM Anti-tumor Molecular TherapyIn this course, novel research in the areas of gene transfer, stem cell manipulation, development of gene-, peptide- and protein-, oligonucleotide- and cell-based therapeutics to target key molecules in cancer developments, survival, and metastasis will be addressed. In this subject, a clinical applicability of these molecular therapeutics will be also investigated.

[3]

BMS 672

의과학 암전이의 이해

BM Understanding of MetastasisIn this course, metastasis of cancer cells will be investigated from the perspective of physiology, pathology, and molecular biology.

[3]

BMS 673

의과학 암 생물학 주제연구

BM Topics in Cancer BiologyThis discussion lecture will deal with the current understanding in cancer biology. [3]

BMS 674

의과학 암 생물학 세미나

BM Seminars in Cancer BiologyThis seminar provides a forum for the current trends in cancer biology and clinical treatment. Seminar topics will be led by guest speakers.

[3]

BMS 675

의과학 세포화학

BM CytochemistryThis will cover current knowledge of techniques used to confirm the presence of various chemical elements on tissue specimen, particularly immune tissue chemistry, in situ hybridization, and enzyme tissue chemistry.

[3]

BMS 676

의과학 미세조직생물학

BM Ultrastructural Biology of Cell and Tissue

This course will provide an overview of the interactions among, and functions of cell and tissue structures.

[3]

BMS 677

의과학 유전자의 발현 조절

BM Regulation of Gene ExpressionIn this course, students will learn about expressed structures of normal genes, revelation control me-tabolism of genes, mutation of abnormal-revelation genes, cellular apoptosis, abnormal metabolism and interaction of disease-induction.

[3]

BMS 678

의과학 노화의 생물학

BM Biology of AgingThis course will cover the hypotheses and mechanisms of aging and various age-related diseases. [3]

BMS 679

의과학 고급인체생화학

BM Advanced Human BiochemistryThrough this course, students will learn about the physics of biochemical and molecular biological metabolism and pathology.

[3]

BMS 680

의과학 세포주기조절 및 세포사멸

BM Cell Cycle and ApoptosisThis course will deal with the interaction of various proteins related to cell cycle, metabolism control, and protein phosphorylation. Also, it will cover cascades and interaction of genes and proteins that control proliferation, differentiation and cellular apoptosis.

[3]

BMS 681

의과학 생명공학

BM BiotechnologyThis course will provide basic application techniques which are essential to biochemical, molecular biological, and cellular biological technology and industrial application of medical biology.

[3]

BMS 684

의과학 신경발생유전학

BM Neurodevelopmental geneticsThe neurons and nervous systems of all multicellular animals share many common features. The ob-jective of this course is to provide understanding of the mechanisms responsible for the generation of nervous systems, highlighting examples from a variety of organisms.

[3]

BMS 685

의과학 고급발생생물학 I

BM Advanced Developmental Biology IDevelopmental biology is one of the fastest growing fields in biology and has become essential for understanding all other areas of biology. This course will cover all the subjects required to understand developmental biology at the molecular level.

[3]

BMS 686

의과학 고급발생생물학 II

BM Advanced Developmental Biology IIDevelopmental biology is one of the fastest growing fields in biology and has become essential for understanding all other areas of biology. This course will cover all the subjects required to understand developmental biology at the molecular level.

[3]

BMS 695

의과학 감염면역학

Immunology of Infectious DiseasesThis course aims to provide basic knowledge in the immunology of infectious diseases through a compre-hensive range of teaching and literature reviews/discussion. It will address basic concepts of immunology, mechanisms of bacterial pathogenesis, viral infectious diseases and immunity, and parasitic diseases and immunity.

[3]


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