PharmaCircle™ For Research, Development, Regulatory,and Business Development Professionals

Much More Than a Simple Pipeline Database

An Overview for Pharmaceutical Professionals

PharmaCircle Corporate Snapshot

• 2003 - Founded– Focus on drug delivery and formulation information

• 2013– Full complement of research, development, regulatory and

business modules

– Servicing >90% of Big Pharma companies

– Worldwide database coverage: USA, Europe, Japan, Canada, New Zealand and more

– The leader in drug delivery and formulation information and analysis

– Proprietary search engines providing unique information access

Why PharmaCircle?

• PharmaCircle’s management team brings you decades of first-hand experience in the field.

• PharmaCircle’s analyst team tracks hundreds of unique company, product and technology specific details that are searchable in more than 40 different search modules

• PharmaCircle’s drug delivery, formulation, excipient and delivery device related content and analysis is not available any where else

• PharmaCircle uses cutting edge search and display technologies developed by it’s internal IT team

– Extensive analytics capabilities in the form of dynamic and interactive tables and 2D/3D charts

• Prompt customer support delivered by top management is unparalleled in the business.

PharmaCircle Users

• Pharmaceutical Sciences• Product Development• Regulatory• Information Services• Competitive Intelligence• Business and Corporate Development• Research• Clinical Development• Licensing • Legal• Consultants • Animal Health

Information Sources

• Daily news –RSS Feeds

• Clinical trial records: US, EU, Japan, WHO and others

• Quarterly/annual Financial documents: US, EU, Japan, Asia..

• Regulatory sites for US,CANADA, EU, Japan (FDA, HCA, EMA, HMA, PMDA…) and many other countries

• Meetings (Drug Delivery), company presentations &Web sites

• Patents Worldwide – EU Patent Office

Easy access to >40 Search Modules

Broad Scope of Pharma Information

Rx Products Biologics OTC Generics Vaccines Veterinary

PipelinesFDA Paragraph

IV

DEA Scheduled

Products

Administration

Routes & DetailsSupply Chain

Discovery

Technologies

CompaniesFDA Approval

PackagesUSA Dosage Forms

Drug Delivery

Technologies

Drug Delivery

Patents

GenericsFDA Adverse

EventsEurope Excipients

Drug Delivery

Patents

Administration

Routes & Details

EU/US Clinical

Trials

FDA Drug Master

FilesJapan Formulation Data Product Sales Combinations

FDA/EU/Japan

Labels

FDA Orange

BookCanada Injection Sites

Deals &

Acquisitions

Industry News &

History

FDA Exclusivity FDA ApprovalsMechanism of

ActionR&D Costs Venture Finance FDA Dissolution

Extensive Coverage

70,000+ Products & Pipeline

26,000+ Molecules

10,000+ Companies

4,600+ DD Technologies

1,100+ Discovery Technologies

160,000+ Clinical Trials

15,000+ Deals/transactions

12,000+ Excipients

120,000 News

37,000+ FDA Products

38,000+ EU Products

17,000+ Japan Products

46,000+ Canada Products

25,000+ Drug Master Files

4.2+ million Adverse Events+

10,000+ Product Sales

6,000+ Veterinary Products

1,200+ Paragraph IV filings

Cutting Edge Search and Display Technologies

• Detailed and Flexible search technologies– Detailed Search offers numerous search fields providing targeted search

capabilities– Flexible Search technology provides Boolean search capabilities that permit

nested fields and number based searches– Dynamic 2-D and 3-D charting of search results is available in both Flexible and

Detailed Search modes– Users can dynamically change/add content to results tables from a set of

variables – Provide the ability to save searches and create RSS feed updates – Tables and charts can be exported as PDF, Excel and Word documents

• Panoramic Search technology is exclusive to PharmaCircle – Provides instant display of search results as tables and charts spontaneously

• All search fields provide auto fill to more easily define the right search term

Innovative Search SolutionsDefine search locations by circling the area on a map

Panoramic (Tabbed) Pipeline Search

1700 Mechanisms

Export to Excel

Panoramic Deals & Acquisitions Search

Search Interfaces - Detailed Search Engine

Search Interfaces - Flexible Search Engine

Full Boolean search capabilities

Product and Pipeline Information

Extensive product details include:

– Product photographs

– Molecule information

– Development/Marketing status

– How Supplied information

– Administration and dosing details

– Regulatory details with links to filings and monographs

– Key patent information

– Formulation and excipients

Extensive Product Details

Data Tables (interactive)

Reports(downloadable)

2-D & 3D Charts (interactive)

Compare/Contrast Tables (interactive)

Multiple Output Options

Tabbed Excel Files(downloadable)

Best-in-Class Drug Delivery Content

• In depth technology reports– 41 separate reports (100+ pages, review and analysis)

• Unique technology compare and contrast tables– 48 customizable compare and contrast tables

• Excipient details

• Drug delivery device information

• Analytical testing information

• PharmaCircle management are Pharma alumni with extensive drug delivery and formulation experience

Unique Technology Analysis

Disposable Autoinjectors, > 30 Devices Analyzed.One of more than 40 technology compare and contrast groups.

Unique Content

R&D Regulatory Business Other

Products / Pipeline Products / Pipeline Products / Pipeline Veterinary Products

Product (FDA) Product (FDA) Deals / Acquisitions Vaccines

Discovery Technology EU Label (Eudrapharma) Venture Capital Combination Products

Formulation/DD Technology US Label (FDA) Companies

Excipients (FDA) Japan Label (PMDA) R&D Cost

Molecule Info Canada Label (HPB) News/History

DD Patents Approval Package (FDA) Product Sales

Clinical Trials (FDA) Adverse Events (FDA) Lifecycle Studies

Clinical Trials (EU) Packaging Info (FDA) Packaging Info (FDA)

Dissolution Methods Paragraph IV (FDA) Supply Chain (NZ)

DD Technology Reviews Drug Master Files (FDA)

DD Technology Tables Orange Book (FDA)

Continuous Enhancements

New Modules & Services for 2013• A single search module to search across global regulatory

content from FDA, EMA, HMA, EMC, Health Canada, Japan PMDA and more

• FDA Advisory Committee meetings content search

• Medical device search

• FDA Warning letters (Form 483) search module

• Emerging market regulatory databases, Brazil, Turkey, Mexico and more

• Formulation details that provide excipient amounts for injectables and non-injectable pharmaceuticals

Customer Service

• Customer service is a top priority for PharmaCircle

– Email and phone support included

– Every request handled by top company management, not junior level personnel

• Customized training sessions

• Online videos available for self learning

• No additional charge for custom searches (full package subscribers)

PharmaCircle – The Bottom Line

• Integrated one stop information

• Comprehensive pharmaceutical data for the R&D, Regulatory and Business needs of Pharma

• Intuitive and powerful search modules

• Dynamic charting & flexible output

• Unique databases provide data not available elsewhere

• Exclusive source of drug delivery and formulation information

• Customer service provided by senior management

Additional Information and Online Demo:

Dr. Tugrul Kararli, President and FounderPharmaCircle LLCEncinitas, CA, USAEmail: tkararli@pharmacircle.comTel: +1-760-436-1199