OCTOBER/NOVEMBER 2015 • VOL. 14 NO. 5

Integrative Medicine: A Clinician’s Journal

Integrative Therapies and Cardiovascular Disease in the Breast Cancer Population • Whole-person Integrative Eating: Treating Overeating, Overweight, and Obesity • Nutrition for Relief of Joint Discomfort • Research Battles: Survival Tips From a Veteran • Personalized Lifestyle Medicine Institute 2014 • Case Reports, Clinical Practice Guidelines, and Evidence • Bland—Functional Medicine: An Operating

System for Integrative Medicine • Presenters 2015—Dale E. Bredesen, MD: Reversing Cognitive Decline • Interview With Barbara Dossey, PhD, RN • Editorial—Conventional

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Integrative Medicine • Vol. 14, No. 5 • October 2015 3Table of Contents

8 The Path Ahead—Conventional Laboratory Tests to Assess Toxin Burden Joseph Pizzorno, ND, Editor in Chief

18 Creating Synthesis—Functional Medicine: An Operating System for Integrative Medicine Jeffrey Bland, PhD, Associate Editor

78 Case Reports, Clinical Practice Guidelines, and Evidence David S. Riley, MD, Associate Editor

88 BackTalk—Quit Your Bellyaching Bill Benda, MD, Associate Editor

22 The Blue Zone Intersection: What Role for Integrative Health in Community Health? … plus more John Weeks

30 Research Battles: Survival Tips From a Veteran Linda L. Isaacs, MD

64 Personalized Lifestyle Medicine Institute, October 2014: A Seminal Moment in the 21st Century’s Transformation of Health Care Lara Pizzorno, MDiv, MA, LMT

33 Integrative Therapies and Cardiovascular Disease in the Breast Cancer Population: A Review, Part 2 Khara Lucius, ND, FABNO; Kristen Trukova, MS, RD, CSO, CNSC, LDN

42 Whole-person Integrative Eating: A Program for Treating Overeating, Overweight, and Obesity Deborah Kesten, MPH; Larry Scherwitz, PhD

52 Nutritional Approach for Relief of Joint Discomfort: A 12-week, Open-case Series and Illustrative Case Report Robert H. Lerman, MD, PhD; Jyh-Lurn Chang, PhD; Veera Konda, PhD; Anuradha Desai, PhD; Michael B. Montalto, PhD

26 Dale E. Bredesen, MD: Reversing Cognitive Decline Interview by Craig Gustafson

72 Barbara Dossey, PhD, RN: Developing a Healing Approach in Nursing Interview by Craig Gustafson

80 Conference Calendar

EDITORIALS

COMMENTARY

VIEWPOINTS

Integrative Medicine: A Clinician’s Journalwww.imjournal.com

October/November 2015 • Vol. 14 No. 5

REVIEW ARTICLE

PRESENTERS 2015

EPTHECA

CASE STUDY

ORIGINAL RESEARCH

Tel: 805.693.1802 • Fax: 805.693.1806 • CustomerService@ResearchedNutritionals.comwww.ResearchedNutritionals.com | Available only through healthcare professionals

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*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

Joseph Burrascano Jr., MD“Due to the research basis of these formulations, I think these products would be an important part of a practitioner’s arsenal.”

Healthy Cytokine SupportCytoQuel™ has been developed to promote healthy cytokine activity. Based on the latest published research, CytoQuel™ offers doctors a valuable new tool in the quest for healthy inflammation levels.

Each capsule includes therapeutic levels of:

( N-acetyl cysteine (NAC) ( Black Tea Extract ( CurcuWIN™ tumeric extract ( Pure Tocotrienols (optimized absorption) ( Resveratrol (Natural Trans-Resveratrol)

Microbinate™ is formulated to promote a healthy response to today’s vast microbial challenges. Each capsule combines nature’s most potent and well-researched nutrients into one complete product with therapeutic levels of:

( Oregano Extract (30% carvacrol) ( Monolaurin ( Olive Leaf Extract ( Stabilized Allicin (the active ingredient in garlic) ( CurcuWIN™ tumeric extract

Microbial Health Complex

Microbial & CytokineSupport

Integrative Medicine • Vol. 14, No. 5 • October 20154 x

Editor in Chief Joseph Pizzorno, nd

drpizzorno@innovisionhm.com

IMCJ Associate Editors

Lise Alschuler, ND, FABNO ◆ Executive Director, TAP Integrative; Coprinciple, Thrivers; Clinician, Naturopathic Specialists

Jeremy Appleton, ND ◆ Nature’s Way Brands

Phillip Barr, MD ◆ Concierge Health Consultants

Donald M. Blair, DDS, ND ◆ Bellevue, WA

O’Dane Brady, DC, MSc ◆ World Spine Care

Andrew W. Campbell, MD ◆ Editor in Chief, Alternative Therapies in Health and Medicine

Alan R. Gaby, MD ◆ Concord, NH

Steve Given, DAOM, LAc ◆ American College of Traditional Chinese Medicine

Elizabeth A. Goldblatt, PhD, MPA/HA ◆ Academic Consortium of Complementary and Alternative Health Care (ACCAHC)

Patrick Hanaway, MD ◆ Cleveland Clinic

Mary L. Hardy, MD ◆ Stiles Integrative Oncology Program at UCLA; Wellness Works

Mark Hyman, MD ◆ Institute for Functional Medicine; The Center for Mind-Body Medicine; The UltraWellness Center

Loren D. Israelsen, JD ◆ President, United Natural Products Alliance

Clyde B. Jensen, PhD ◆ University of Western States; Oregon Collaborative for Integrative Medicine; Association of Health Sciences Colleges and Universities

Claire Johnson, DC, MSEd, DACBSP ◆ National University of Health Sciences

Herb Joiner-Bey, ND ◆ Barlean’s Organic Oils

Robert H. Lerman, MD, PhD ◆ Adjunct Associate Professor of Medicine, Boston University School of Medicine

DeAnn Liska, PhD ◆ Sr. Director Nutrition & Scientific Affairs, Biofortis Nutrition Research, a Merieux NutriSciences Company

Chongyun Liu, OMD, LAc ◆ Bastyr University

Rick Liva, ND, RPH ◆ Connecticut Center for Health; Vital Nutrients

Michael R. Lyon, MD ◆ Diplomate of the American Board of Obesity Medicine; Adjunct Professor, University of British Columbia; Food, Nutrition and Health Research Director, Canadian Center for Functional Medicine; Medical Director, Medical Weight Management Centre

Douglas MacKay, ND ◆ Senior Vice President, Scientific & Regulatory Affairs, Council for Responsible Nutrition

Antonio C. Martinez, II, JD ◆ Attorney at Law

Robert Martinez, ND, DC, DABCO ◆ Private Practice, Kirkland, WA

David Matteson, MPH, MS, MPA, APR ◆ Early Edge Solutions, Nativis

Gerard E. Mullin, MD ◆ Division of Gastroenterology and Hepatology, Johns Hopkins Hospital

Stephen P. Myers, ND, PhD, BMed, FACNEM ◆ Southern Cross University, Australia

Paula J. Nenn, MD, ABIHM, MRCP(UK) ◆ States of Jersey, Department of Medicine; University of Southampton

David Perlmutter, MD, FACN, ABIHM ◆ Perlmutter Health Center

Lara Pizzorno, MA (Div), MA (Lit), LMT ◆ Editor, Longevity Medicine Review; Integrative Medicine Advisors, LLC; Salugenecists, Inc

Ronald G. Reichert, ND ◆ Boucher Institute of Naturopathic Medicine; Bioclinic Naturals

Corey Resnick, ND ◆ Integrative Health & Nutrition; Integrative Therapeutics

Jacob Schor, ND, FABNO ◆ Denver Naturopathic Clinic; Fellow, American Board of Naturopathic Oncology; Associate Editor, The Natural Medicine Journal; Board Member and Past President, Oncology Association of Naturopathic Physicians

Vivek Shanbhag, ND, MD(Ayur) ◆ YogaAyurveda.org; Natural Medicine Clinic & Academy; Adjunct Faculty, Bastyr University & MMI Ayurveda College

Andrew David Shiller, MD ◆ Integrative Rehabilitation Medicine, Suffern, NY; The Valley Hospital, Ridgewood, NJ

Pamela Snider, ND, PhND(Hon) ◆ Executive and Senior Editor, Foundations of Naturopathic Medicine Project; Associate Editor, National College of Natural Medicine; Adjunct Faculty, Bastyr University

Nancy Sudak, MD, ABIHM ◆ Academy of Integrative Health & Medicine

Kathie Madonna Swift, MS, RDN, LDN, FAND ◆ Saybrook University School of Mind Body Medicine; Dietitians in Integrative and Functional Medicine

Melvyn R. Werbach, MD ◆ Tarzana, CA

Jonathan V. Wright, MD ◆ Tahoma Clinic

IMCJ Editorial Board

Statement of PurposeIntegrative Medicine: A Clinician’s Journal® provides clinicians with peer-reviewed, scientifically accurate, practical information about the integration of conventional and natural medicine. Integrative Medicine: A Clinician’s Journal is indexed in CINAHL. The views expressed in this journal are those of the authors and not necessarily those of the publisher or its advertisers. Integrative Medicine: A Clinician’s Journal® (ISSN 1546-993X) is published 6 times per year (in February, April, June, August, October, and December) by InnoVision Professional Media, Copyright ©2015. Cover image used under license from Shutterstock.com, 2015 All rights reserved. No part of this publication may be reproduced in any medium or photocopied without written permission from the publisher. Individual subscriptions to Integrative Medicine: A Clinician’s Journal must be prepaid in US dollars only and are available for $85 for one year. To order or for subscription address changes, write, fax, or call: Integrative Medicine: A Clinician’s Journal, PO Box 11292, St. Paul, MN 55111 • Toll Free: (877) 904-7951 • Phone: ( 651) 251-9684

Sidney MacDonald Baker, MD Autism Research Institute

Bill Benda, MD, FAAEM Senior Graduate Fellow, Program in Integrative

Medicine, University of Arizona;St. Mary's Medical Center in West Palm Beach, FL

Jeffrey Bland, PhD, FACN, FACB Cofounder, Institute for Functional Medicine;

Founder, Personalized Lifestyle Medicine Institute

Tori Hudson, ND Medical Director, A Woman’s Time; Program Director, Institute of Women’s Health and Integrative Medicine;

Research/Education Director, Vitanica

Jennifer C. Lovejoy, PhD, CNS Institute for Systems Biology

David S. Riley, MD Academy of Integrative Health and Medicine; Integrative Medicine Institute; National College of Natural Medicine

Darcy Vavrek, ND, MSUniversity of Western States

David Wickes, DC, FICC, Dipl ABCI Canadian Memorial Chiropractic College

Integrative Medicine: A Clinician’s Journalwww.imjournal.com

October/November 2015 • Vol. 14 No. 5