INTERACTION OF GENETIC AND ENVIRONMENTByTaufik Rahman, M.D

HostEnvironment Agent

EnvironmentInfective agentChemical agentPhisical agentRadiationMechanical trauma

HostBiologycal characteristic age, sex, racial and herediter Anatomical of the body Phisiological of the body Imunity Biologycal ability interaction of host and agent Nutrient status and healthy status Social characteristic

Causes of the diseaseInfective agent bacterials, viruses, parasite, fungusChemical agent drugs, toxin, colouring subtances, preservativePhisical agent heat, trauma, radiation

Bacterial causes of the human diseasSalmonella thyposa: typhoid feverShigella dysenteriae: dysentriVibrio coma: choleraHaemophillus influenza: influenzaM. tuberculosa: tuberkulosisClostridium tetani: tetanusN. meningitidis: meningitisN. gonorrhoeae : gonoreT. pallidum: siphilisM. leprae: lepra

Viruses causes of the human diseaseDNA virusesHerpesviridae: HerpesPoxviridae: smallpoxPapovaviridae: warts

Viruses causes of the human diseaseRNA virusesOrthomyxoviridae: influenzaRhabdoviridae: rabiesHepatitis virus: hepatitisRetrovirus: AIDSPicornaviridae: poliomielitisTogaviridae: yellow fever, encephalitisArenaviridae: Meningitis

Parasite causes of human disease

Worm : ascaris lumbricoides Enterobius vermecularis Ancylostoma duodenale taenia saginata/ taenia soleum Trichuis trichiura Brugia malayiPlasmodium : malariae, vivax, ovale, falciparum

Fungus causes of human diseaseMalassezia furfur: pitiriasis versikolorAspergillus: otomikosisRhizopus: otomikosisPiedra hortai: black piedraPiedra beigelli: white piedraCandida: kandidosisMicrosporum, Trichopyton: Tinea Misetoma: maduromikosis

Chemical agentArsen : bone necrosisBismuth: ginggivostomatitis

Genetical diordersMultifactorial orcomplex gene disorderSingle gene disorderAutosomal dominantAutosomal resessiveX-linked dominantX-linked resessiveMitochondrial

Autosomal dominantHuntington diseaseNeurofibromatosisMarfan sindrome

Huntington disorder

Marfan disorder

Autosomal resessiveCystic fibrosisSickle-cell diseaseTay-Sachs disease

Cystic fibrosis

Sickle Cell disease

X-linked dominantKlinefelter syndromeRete syndromeIncontinentia pigmenti type 2Aicardi syndrome

Klinefelter syndrome

Aicardi syndrome

X-linked resessiveHemophilia ADuchenne Muscular dystrophyLesch-Nyhan syndrome

Hemophilia A

Duchenne Muscular Dystrophy

Multifactorial/complex gene disorderAstmaAutismMultiple sclerosisCancerCleft palateDiabetesIrritabel Bowel diseaseHypertension

Any questionplease