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PSYCH:OPHIARMACOLOGYSymposium at the December 1954 AAAS Berkeley Meeting

Edited by NATHAN S. KLINEDirector of Research at Rockland State Hospital, Orangeburg, New York;

College of Physicians and Surgeons, Columbia University

Foreword by WINFRED OVERHOLSERSuperintendent, Saint Elizabeths Hospital, Washington, D.C.

6 x 9 inches, 175 pages, 11 tables, 3 figures, bibliographies, index, clothbound, 1956Price $3.50. AAAS Members' prepaid order price, $3.00

Publication No. 42 of the American Association for the Advancement of Science

Unlike earlier drugs that clouded the consciousness of the mental patient or even rendered him unconscious, chlor-promazine and reserpine "have the unusual property of sedating the patient, reducing his overactivity, and allaying hisanxiety, while at the same time he remains fully conscious and thus far more amenable to the various other therapeuticapproaches of a psychological nature. Add to this the facts that the drugs are almost free from untoward side effects,and that they are non-addictive, and it is easy to see why an extraordinary enthusiasm over their possibilities has beenexhibited." (W. Overholser)

This first major conference on the use of chlorpromazine, reserpine, and related drugs covers treatment of schizo-phrenia, psychoneuroses, manic depression, and chronic alcoholism in children, adolescents, and adults of both sexes.

Methods of treatment, side effects, results, and conclusions are presented with case histories and proper cautions aboutnot considering these new drugs panaceas. Discussions of the papers introduce the valuable experience and observationsof additional leaders in the field.

This volume will be of the utmost importance to psychiatrists, neurologists, clinical psychologists, physiologists,pharmacologists, and biochemists.

CONTENTSClinical Observations with ChlorpromazineLESTER H. MARGOLIS, AMES FISCHER, ROB-ERT N. BUTLER, and ALEXANDER SIMON,University of California School of Medicine and theLangley Porter Clinic, Department of Mental Hly-giene, State of California, San Francisco

Clinical Application of ChlorpromazineVERNON KINROSS-WRIGHT, Department of Psy-

chiatry and Neurology, Baylor University College ofMedicine, Houston, Texas

Clinical Applications of Chlorpromazine in PsychiatryANTHONY A. SAINZ, Marcy State Hospital, Marcy,New York.

Considerations on the Cerebral Action of ReserpineANTHONY A. SAINZ

Psychiatric Use of Reserpine and Chlorpromazine:Results of Double-Blind StudiesLEO E. HOLLISTER, LEO TRAUB, and WALLACE

G. BECKMAN, Veterans Administration Hospital,Palo Alto, California

Discussion

Clinical Applications of ReserpineNATHAN S. KLINE

Clinical Trial of Reserpine in Psychotic andPsychoneurotic Illnesses

A. E. BENNETT, Department of Psychiatry, HerrickMemorial Hospital, and the A. E. Bennett Neuro-psychiatric Research Foundation, Berkeley, Cali-fornia

Discussion

Pharmacology of Chlorpromazine, Reserpine,and Related DrugsFREDERICK H. MEYERS, Department of Pharma-

cology and Experimental Therapeutics, School ofMedicine and College of Pharmacy, University ofCalifornia, San Francisco

Studies on Mescaline IV:Antagonism between Mescaline and ChlorpromazineHERMAN C. B. DENBER, Manhattan State Hospital,

Ward's Island, New York, New York, and SIDNEYMERLIS, Central Islip State Hospital, Central Islip,New York

Mechanism of Action of Lysergic AcidDiethylamide, Seratonin, and Related DrugsMURRAY E. JARVIK, Albert Einstein College of

Medicine, New York, New York

DiscussionIndex

AAAS PUBLICATIONS1515 Massachusetts Avenue, NW, Washington 5, D.C.

English Agents: Bailey Bros. & Swinfen, Ltd., 46 St. Giles Street, London W.C.2

SCIENCE, VOL 123

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