international pancreas transplant registry
DESCRIPTION
International Pancreas Transplant Registry. Pancreas Transplants. Pancreas Transplants 12/16/1966 – 12/31/2009. USA : n = 23,850 Non USn = 11,365. 1/10. US Pancreas Transplants. USA Pancreas Transplants 12/16/1966 – 12/31/2010. USA: n = 25,031. 1/11. - PowerPoint PPT PresentationTRANSCRIPT
IPTR /UNOS
International Pancreas Transplant Registry
IPTR /UNOS
Pancreas Transplants
pre 7819781979198019811982198319841985198619871988198919901991199219931994199519961997199819992000200120022003200420052006200720082009
0
200
400
600
800
1000
1200
1400
1600
Pancreas Transplants 12/16/1966 – 12/31/2009
USA: n = 23,850 Non US n = 11,365
1/10
IPTR /UNOS
US Pancreas Transplants
pre 781979
1981
1983
1985
1987
1989
1991
1993
1995
1997
1999
2001
2003
2005
2007
2009
0
200
400
600
800
1000
1200
1400
1600
USA Pancreas Transplants 12/16/1966 – 12/31/2010
USA: n = 25,031
1/11
IPTR /UNOS
19881989199019911992199319941995199619971998199920002001200220032004200520062007200820092010
020406080
100120140160
02004006008001000120014001600# Cen-
ters# of Txs
Centers
Number of Tx Centers and Number of Txs
01/11
Transplants
USA Pancreas Transplants 1/1/1988 – 12/31/2010
IPTR /UNOS
Pancreas Transplant CategoriesUSA SPK, PAK and PTA Transplants 1/1/1988 – 12/31/2010
01/11
198819901992199419961998200020022004200620082010
0
200
400
600
800
1000
1200PTAPAKSPK
Num
ber
of T
rans
plan
ts
IPTR /UNOS
Pancreas RetransplantsUSA Pancreas Transplants 1/1/1988 – 12/31/2010
1/11
1988
/89
1990
/91
1992
/93
1994
/95
1996
/97
1998
/99
2000
/01
2002
/03
2004
/05
2006
/07
2008
/090
20406080
100120140160180
PAKPTASPK
1988
/89
1990
/91
1992
/93
1994
/95
1996
/97
1998
/99
2000
/01
2002
/03
2004
/05
2006
/07
2008
/0920
10/
0
5
10
15
20
25
30
35
40%#
IPTR /UNOS
PAK PTA SPK0
100
200
300
400
500
600
700
800
900
SPKPTAPAK
Primary Transplant Type
# of
ret
rans
plan
ts
USA Primary Pancreas Transplants 1/1/1988 – 12/31/2010
Type of Primary and Retransplant
IPTR /UNOS
Recipient AgeUSA Primary Pancreas Transplants 1/1/1988 – 12/31/2010
PAKPTASPK
IPTR /UNOS
Duration of DiabetesUSA Primary DD Pancreas Transplants 1/1/1996 –12/31/2010
PAKPTASPK
IPTR /UNOS
Age at Tx by Diabetes TypeUSA Primary DD Pancreas Transplants 1/1/2006 –12/31/2010
Type 1Type 2
PAK PTA SPK
20
30
40
50
60
70
Rec
ipie
nt A
ge [Y
rs]
IPTR /UNOS
Diabetes Type and DurationUSA Primary DD Pancreas Transplants 1/1/2000 –12/31/2008
Type 1Type 2
PAK PTA SPK0
10
20
30
40
50
60
Dur
atio
n of
Dia
bete
s [Y
rs]
IPTR /UNOS
Recipient GenderUSA Primary DD Pancreas Transplants 1/1/1988 – 12/31/2010
1/11
1988
/89
1990
/91
1992
/93
1994
/95
1996
/97
1998
/99
2000
/01
2002
/03
2004
/05
2006
/07
2008
/0920
10/
010203040506070
PAKPTASPK
% Male
IPTR /UNOS
Patients with Type 2 Diabetes USA Primary DD Pancreas Transplants 1/1/1994 – 12/31/2010
2/11
1994/95
1996/97
1998/99
2000/01
2002/03
2004/05
2006/07
2008/09
2010/
0123456789
10PAKPTASPK
%
IPTR /UNOS
AfricanAmerican RecipientsUSA Primary DD Pancreas Transplants 1/1/1994 – 12/31/2010
2/11
1994/9
5
1996/97
1998/99
2000
/01
2002/03
2004/0
5
2006/0
7
2008/09
2010
/02468
101214161820
PAKPTASPK
%
IPTR /UNOS
Duct Management TechniqueUSA DD Primary Pancreas Transplants 1/1/1988 –12/31/2010
2/11
1988
/89
1990
/91
1992
/93
1994
/95
1996
/97
1998
/99
2000
/01
2002
/03
2004
/05
2006
/07
2008
/0920
10/
0
20
40
60
80
100PAKPTASPK
% ED drained
IPTR /UNOS
Portal Drainage in ED TxsUSA DD Primary Pancreas Transplants, 1/1/1988 – 12/31/2010
2/11
1996/97
1998/99
2000/01
2002/03
2004/05
2006/07
2008/09
2010/
0
10
20
30
40
50
60PAKPTASPK
%
IPTR /UNOS
Use of a Roux-Loop in ED TxsUSA Primary DD Pancreas Transplants, 1/1/1996 – 12/31/2010
2/11
1996
/97
1998
/99
2000
/01
2002
/03
2004
/05
2006
/07
2008
/0920
10/
0
10
20
30
40
50
60 PAKPTASPK
%
IPTR /UNOS
1988
/89
1990
/91
1992
/93
1994
/95
1996
/97
1998
/99
2000
/01
2002
/03
2004
/05
2006
/07
2008
/0920
10/
0
10
20
30
40
50
60
70
PAKPTASPK
HLA A,B,DR MismatchingUSA Primary DD Pancreas Transplants 1/1/1988 – 12/31/2010
3/11
% of 5 or 6 HLA Mismatch
IPTR /UNOS
Anti-T-Cell InductionUSA DD Primary Pancreas Transplants 1/1/1988 – 12/31/2010
2/11
1988
/89
1990
/91
1992
/93
1994
/95
1996
/97
1998
/99
2000
/01
2002
/03
2004
/05
2006
/07
2008
/0920
10/
0
20
40
60
80
100
PAKPTASPK
%
IPTR /UNOS
Class I PRA levels > 20%USA DD Primary Pancreas Transplants 7/1/2004 – 12/31/2010
2/11
2004
/05
2006
/07
2008
/0920
10/
0
4
8
12
16
PAKPTASPK
%
IPTR /UNOS
Class II PRA levels > 20%USA DD Primary Pancreas Transplants 7/1/2004 – 12/31/2010
2/11
2004
/05
2006
/07
2008
/0920
10/
0
4
8
12
PAKPTASPK
%
IPTR /UNOS
SPK Induction Antibody TherapyUSA DD Primary Pancreas Transplants 1/1/2000 – 12/31/2010
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 20100
102030405060708090
No AbsDepl Abs NonDepl AbsBoth
Transplant Year
%
3/11
IPTR /UNOS
PAK Induction Antibody TherapyUSA DD Primary Pancreas Transplants 1/1/2000 – 12/31/2010
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 20100
1020304050607080
No AbsDepl Abs NonDepl AbsBoth
Transplant Year
%
3/11
IPTR /UNOS
PTA Induction Antibody TherapyUSA DD Primary Pancreas Transplants 1/1/2000 – 12/31/2010
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 20100
102030405060708090
100
No AbsDepl Abs NonDepl AbsBoth
Transplant Year
%
3/11
IPTR /UNOS
PAK PTA SPK0
10
20
30
40
50
60
70
80
90%
Antibody TherapyUSA Primary DD Pancreas Transplants 1/1/2006 – 12/31/2010
No ABs Depl. AB NonDepl. AB Both ABs
3/11
IPTR /UNOS
Overall Initial Steroid AvoidanceUSA Primary DD Pancreas Transplants 1/1/2000 – 12/31/2010
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 20100
1020304050607080
SPKPAKPTA
Transplant Year
%
3/11
IPTR /UNOS
PAK PTA SPK0
20
40
60
80
MMFCsA/MMFTAC/MMFTACSRL based
%
Major Immunosuppressive ProtocolsUSA Primary DD Pancreas Transplants 1/1/2006 – 12/31/2010
3/11