International Regulome Consortium

Toronto – October 29, 2005Cindy Bell, VP, National Genomics ProgramGenome Canada

Genome Canada – Organizational Structure

Genome Centres

Board of Directors

Science and Industry Advisory Committee

Prairie

Ontario

Québec

Atlantic

B.C.

Genome Canada(President & CEO)

Functional Genomics GenotypingSequencingProteomics

Bioinformatics Automation

GELS

Funding and Investments

GenomeCanadalaunch

2000 2001 2002 2003 2004 2005 2006

Comp Iprojectsbegin

Comp IIprojectsbegin

AppliedHealthprojectsbegin

Comp IIIprojectsbegin

Comp I &Comp IIprojectsend

FederalBudget2000$160 M

FederalBudget2001$140 M

FederalBudget2003$75 M

FederalBudget2004$60 M

FederalBudget2005$165 M

Genome Canada = $600 millionPartner Funding = $600 millionTotal Funding = $1,200 million

Sectors

Genome Canada Portfolio

(September 2005)

B.C. Prairie Ontario Quebec Atlantic Total

Agriculture 2 4 1 1 8

Bioinformatics 1 1

Environment 1 2 1 4

Fisheries 2 2 4

Forestry 2 1 2 1 6

GE3LS 2 2 3 2 9

Health 18 4 20 20 3 65

Technology

Development

2 3 5

Platforms 5 1 2 1 1 10

Total Projects 32 13 33 26 8 112

50 Genome Canada-funded projects are expected to end by March 31, 2006.

Why International?

Leverage core StrengthsComplementary ScienceFacilitiesResourcesFunding

Visibility / Branding Recruitment Emerging Opportunities

National Genomics StrategyInternational Partners

Sweden

U.K.Denmark

Spain Norway

GenomeCanada

GenomeQuebec

GenomeAtlantic

GenomeOntario

GenomeB.C.

Nether-lands

Estonia

GenomePrairie

USA

Australia

International Projects – Mechanisms for Support

• Investigator Initiated (regular application to Genome Canada with an international

partner)

• Bilateral Competition (e.g., Genome Canada/Geñoma Espana)

• Community Led (e.g., Bovine project)

• International Consortium Initiative (e.g., SGC)

September 2005

USA 30 %

UK 25 %

Japan 25 %

China 10%

Canada 10 %The HapMap will describe patterns of DNA sequence variation. It will be a key resource to find genes and responses to drugs.

TitleHigh Throughput Mammalian Functional Analysis for the Discovery of Novel Determinants of Human Disease

Goals The International Knock-out Mouse Project is a worldwide effort to generate knock-out mutations in every gene in the mouse genome

Budget (CDN$) $23.6 million (maximum approved budget)

PartnersAffiliated with the European Conditional Mouse Mutagenesis Project

Project LeadersGeoff Hicks, University of ManitobaJanet Rossant, Mount Sinai Hospital

North AmericanConditional MouseMutagenesis Project

Project Locations Canada Spain

Flatfish Genomics

(Halibut & Sole)

IMB, Halifax

IRTA, Barcelona

$ 2.0 M $ 3.0 M

Grapevine Genomics

(Wine & Table grapes)

UBC, Vancouver

CSI, Madrid

$ 3.1 M $ 3.1 M

Neurodevelopment Disorders University of Toronto

CRG, Barcelona

$ 2.6 M $ 2.6 M

TOTALS $ 7.7 M $8.7 M

Genome CanadaGenoma España

Joint Projects

Total Budget $53 million US

Funding Partners NIH’s NHGRI $25 million

USDA 11 million

State of Texas 10 million

Genome Canada 5 million

Australia & New Zealand 2 million

Sequencing Efforts

Genomic DNA sequencing – Baylor College of Medicine

Gene sequencing – Genome BC platform at BC Cancer Agency & U. of Alberta

Bovine GenomeSequencing Project

(Bos taurus)

International Consortium Initiative

• Designed for unique international projects with potential for significant impact on Canadian science

• Project must be led by a Canadian researcher and request a minimum of $50 million over 3 years

• Genome Canada will pay up to 25% of total costs

• Workshop funds available to help develop consortia

• One proposal and five workshops have been approved to date

September 2005

Goals

Determine the three-dimensional structure of more than 350 human proteins

Encourage the development of new and improved drugs

Location Univ. of Toronto (lead) and Univ. of Oxford

CEO Aled Edwards, University of Toronto

Funding

(CAN$ over 3 yrs)

Wellcome Trust $46 MNordic Node $15 MGenome Canada $15 MORDCF $15 MOIT $ 7 MGlaxoSmithKlein $ 6 MCIHR $ 6 M TOTAL= $110 M

FeaturesLargest health research project funded in CanadaProtein structures will be in public domain

Canada-UK Structural Genomics Consortium

Canada

Finland, Sweden, Norway, Denmark, Netherlands, UK

Estonia

United Kingdom

Vision: Foster international harmonization for public projects in population genomics

Public Population Project in Genomics

150 rue Metcalfe Street, Suite 2100Ottawa, OntarioCANADA K2P 1P1Tel: (613)751-4460Fax: (613)751-4474

info@genomecanada.ca

www.genomecanada.ca