international society for magnetic …cds.ismrm.org/protected/mrpulse/mrpulsev9_3.pdfimaging, mr...

MLetter From The President

any members of our Society will soon be observing the 20th anniversary of Magnetic Resonance Imaging in clinical practice. This occasion will provide

an excellent opportunity for clinicians and researchers in diagnostic imaging to remind our medical colleagues of theprofound contribution to clinical care that has resulted from the introduction of high-tech medical imaging. Forexample, until the 1980’s, surgery for purely exploratory purposes was still a relatively common procedure. With wideruse of powerful imaging technologies providing a “window” into the human body, such exploratory surgery is nowessentially a thing of the past.

While industry has played an important role in the development of MRI technology, it is remarkable that manyof the most critical advances have been pioneered by individual researchers at universities and medical institutions

It is thus ironic that research in medical imaging technologies has long been regarded by many in the medical researchcommunity as somehow less meritorious than traditional disease-oriented research. Historically, these attitudes have placedsome researchers in imaging science at a disadvantage in competing for grant funding from federal agencies.

Fortunately, these attitudes are changing. For instance, the National Cancer Institute, one of the largest fundingagencies within the US National Institutes of Health has formally recognized imaging research as one of several“Extraordinary Opportunities for Investment” over the last several years and has become a major supporter of suchresearch. In 2001, the new National Institute of Biomedical Imaging and Bioengineering was formed at the NIH.A prominent member of our Society, Dr. Roderic Pettigrew, has recently been appointed as the first permanent Directorof this Insititute. In addition, another prominent member of our Society, Dr. Elias Zerhouni, has become the firstRadiologist to serve as Director of the NIH.

Such events signal an increasing recognition by the medical research community of the importance (and legitimacy) ofbasic and applied research in imaging and bioengineering. This is a worldwide phenomenon that should contribute tothe career success of the many members of the ISMRM who depend on medical research grant funding for their work.

Historically, the ISMRM has been proactive in its advocacy for imaging research. It has provided support to groupssuch as the Academy of Radiology Research (an alliance of 26 Societies and organizations). We have sent delegates tointersociety meetings focused on research funding and have sponsoring workshops on the topic. These efforts,mandated by our Articles of Incorporation, are bearing fruit, but must be continued.

I would deeply appreciate any comments or suggestions from members of our Society on how we can be moreeffective in this important mission.

INTERNATIONAL SOCIETY FOR MAGNETIC RESONANCE IN MEDICINE

2 Call for Papers2 Important Change to Abstract Submission Procedures, Information for Authors, and New Features for 20033 Preliminary Program of the ISMRM 11th Scientific Meeting & Exhibition14 Educational Stipends for Students and Postdoctoral Trainees15 Clinical Resident Stipend Program16 New Entrant Stipend Program17 E.K. Zavoisky Stipend Program18 SMRT Update19 ISMRM Workshop Report on Diffusion MRI: Biophysical Issues (What Can We Measure?)22 Upcoming ISMRM Workshop on Current Issues in MR Safety23 Two New ISMRM Workshops in 2003 & 2002-2003 Meetings of Interest24 ISMRM Dates and Deadlines

VOL. 9, NUMBER 3 NOVEMBER 2002

INSIDE

METRO TORONTO CONVENTION CENTRETORONTO, ONTARIO, CANADA

— Richard L. Ehman, ISMRM President

2 MR PULSE VOL. 9, NUMBER 3 NOVEMBER 2002

ABSTRACT SUBMISSIONSOnly online submissions will be accepted.Log on to the ISMRM Website(http://www.ismrm.org/03). Click on“Online Abstract Submission” and follow theinstructions.

ABSTRACT SUBMISSION WITHDRAWALWritten requests for withdrawal of Abstractsubmissions from the scientific program,signed by the first author, must be receivedby 20 January 2003 at the ISMRM CentralOffice.

LETTERS OF NOTIFICATIONAuthors will be notified of the decision ofthe Scientific Program Committee inFebruary 2003.

VIDEO AND DIGITAL DATAPRESENTATIONSDigital Data/Video Projection will beavailable at all oral sessions. If you wish tobe considered for single-slide 35mmprojection, you must indicate this at thetime of submission. A further descriptionwill be sent to you following acceptance ofyour abstract for oral presentation.

The Scientific Program Committee invitesAbstract submissions to be presented in oraland poster sessions at the ISMRM EleventhScientific Meeting and Exhibition. Submis-sions must contain new, previously unpub-lished material. The deadline for onlinereceipt of Abstracts is 20 November 2002.

All Abstracts must be submitted electroni-cally, via the ISMRM Website. No paperforms will be available. Any abstractsubmitted on an old paper form will not beconsidered for review.

A 100-word synopsis of each abstract willbe printed in the Program Book. Thissynopsis will also appear at the beginningof the Abstract (i.e., first paragraph). Itshould include a brief description of theproblem, methods, results, and conclusions.It must include text only, with no equationsor images and no references or citations toitems described in the Abstract. If thesubmitted synopsis is longer than 100words, it will be cut short in the ProgramBook.

The Abstract should be submitted in asingle-column format, according to theinstructions found online. You will be ableto compose your abstract and then upload itfor submission.

Detailed instructions for submission areposted on the ISMRM Website. You may alsoreceive submission information by calling,faxing, or writing to the InternationalSociety for Magnetic Resonance in Medicine,2118 Milvia Street, Suite 201,Berkeley, California 94704, USA.

Telephone: +1 510 841 1899FAX: +1 510 841 2340E-mail: [email protected]: http://www.ismrm.org

Information for AuthorsCALL FOR PAPERS

The Eleventh Scientific Meeting & Exhibitionof the International Society for MagneticResonance in Medicine will take place10-16, May 2003 at the Metro TorontoConvention Centre in Toronto, Ontario,Canada. The program for the ISMRM ScientificMeeting will be available online via thePersonal Itinerary Builder provided throughthe ISMRM Website (http://www.ismrm.org).Please call the ISMRM office for moreinformation or e-mail [email protected].

THE 2003 ISMRM SCIENTIFIC MEETINGWILL OFFER THE FOLLOWING NEWSERVICES:

� The Proceedings will be published onCD-ROM only. A paper version of theProgram Book, including the 100-wordsynopsis, will be provided.

� The full text of all accepted abstractswill be available online two weeks beforethe meeting to pre-registered attendeesonly. If you wish to have access to theProceedings before the meeting, youmust pre-register.

� During the meeting, a wireless networkwill be provided through which you willbe able to read your email and access theInternet with your laptop. A limitednumber of email kiosks will be availableas well.

New Features for 2003

THE MEETING

3MR PULSE VOL. 9, NUMBER 3 NOVEMBER 2002

NEUROIMAGINGYukio Miki and Michael D. Phillips, Organizers

Saturday, 10 May, 09:00 - 17:50 andSunday 11 May, 08:30 -15:00

EDUCATIONAL OBJECTIVESUpon completion of the course, participantsshould be able to:� Describe fundamental principles of

diffusion MR, diffusion-tensor MR,perfusion MR and BOLD imaging;

� Describe the current status of high-fieldneuroimaging;

� Apply new techniques in stroke, infection,metabolic disease, white matter disease, sei-zures, cognitive disorders, and brain tumors;

� Describe strength and weakness of MRperfusion imaging vs. CT perfusionimaging, MR angio-graphy vs. CT angiogra-phy, and MR head-and-neck imaging vs. CThead and neck imaging;

� Explain the role of various MR techniquesin the diagnosis of diseases of the spine,and head and neck;

� Discuss the role of MR techniques in theworkup of patients with stroke, white mat-ter disease, infection/inflammation, braintumors, vascular malformations, epilepsy andpituitary disorders;

� Apply MR techniques in various pediatricdiseases of the central nervous system.

PROGRAMDay 1: Saturday, 10 MayPhysics and Techniques09:00 fMRI/BOLD: Physics Basics

Jonathan Burdette09:30 Physics in Diffusion/DTI/Perfusion

ImagingTimothy P.L. Roberts

10:00 Imaging at 3T and BeyondA. Gregory Sorensen

10:30 Break

Clinical Applications and Modalities10:50 Perfusion Imaging: CT vs. MR11:20 Diffusion Imaging Applications in

Stroke, Infection, and MetabolicDiseaseMichael D. Phillips

11:50 DTI Applications in White MatterDisease and Assessment of NeuralNetworksSusumu M. Mori

12:20 Break14:00 Applications of MRA vs. CTA14:30 Clinical fMRI - Pre-op, Seizures,

Cognitive DisordersVincent Mathews

15:00 Diffusion and Perfusion Imagingof Brain TumorsYukunori Korogi

15:30 Break

IMPORTANT DATES

20 NOVEMBER 2002Deadline for online receipt of Abstract submissions.

20 NOVEMBER 2002Deadline for receipt of Student Stipend Applications.

20 NOVEMBER 2002Deadline for receipt of Clinical Resident Stipend Applications.

20 NOVEMBER 2002Deadline for receipt of New Entrant Stipend Applications.

20 NOVEMBER 2002Deadline for receipt of E.K. Zavoisky Stipend Applications.

WEEKEND EDUCATIONAL PROGRAMSPreliminary Program


ADVANCED BODY MRIDonald G. Mitchell and Caroline Reinhold,Organizers

Saturday, 10 May, 08:30 - 17:40 andSunday 11 May, 08:00 - 15:00

EDUCATIONAL OBJECTIVESUpon completion of the course, participantsshould be able to:� Evaluate and recommend pulse sequence

strategies that will optimize body MRimaging and MR angiography;

� Describe cost-effective indications for MRimaging throughout the body;

� Evaluate new pulse sequences based onexisting knowledge of MRI techniques,allowing continuous improvement of bodyMRI and MRA protocols;

� Implement modern MR applications fordiagnosing chest, abdominal, pelvic andvascular diseases;

� Incorporate into their practices recentdevelopments for MR imaging of thepancreas and biliary tract, including MRcholangiopancreatography, and forcomprehensive evaluation of the kidneys;

� Diagnose abdominal vascular diseaseusing state of the art MR angiographictechniques;

� Identify new diagnostic opportunities inMR body imaging.

PROGRAMDay 1: Saturday, 10 May08:30 MRI Safety– FAQ and Controversies

Frank G. Shellock09:00 Body MRI Techniques

Eric Outwater09:40 Body MRI at 3.0 T

Neil M. Rofsky10:20 Break10:40 Focal Liver Lesions– Pattern

RecognitionRichard Semelka

11:15 Diffuse Liver Disease, NodulesDonald G. Mitchell

11:50 PancreasCelso A. Matos

12:30 Break14:00 Biliary System

Riccardo Manfredi14:45 Ovaries: Benign Disease

Evan S. Siegelman15:30 Break15:50 Uterus: Benign Disease

Caroline Reinhold16:30 Gynecologic Malignancy

Lawrence H. Schwartz17:10 Breast MRI

Bruce L. Daniel17:40 Adjournment

Day 2: Sunday, 11 May08:00 Modern Body MRA Techniques

Vincent B. Ho08:40 Aortic Dissection and Aneurysm

Thomas M. Grist09:20 Peripheral Vascular Disease

Stefan G. Ruehm10:00 Break10:20 Comprehensive Renal Imaging

Vivian S. Lee11:10 Bowel: Ischemia and Other Diseases

Russell N. Low12:00 Break13:30 MRI for Screening

Jörg F. Debatin

Spine and Spinal Cord15:50 Degenerative Diseases of the Spine

Jeffrey S. Ross16:10 Imaging of the Postoperative Spine

Michael T. Modic16:30 Intramedullary and Extramedullary

Tumors of the Spinal CordYuichi Inoue

Head and Neck16:50 Head and Neck Tumors

To be announced17:10 Postoperation/Post-Radiation

ImagingSuresh Mukherji

17:30 MR vs. CT in Head and NeckImagingTo be announced

17:50 Adjournment

Day 2: Sunday, 11 MayClinical Topics, Brain: General08:30 Stroke (Acute Stroke and Work-up)

William T.C. Yuh09:00 White Matter Diseases

Vincent Dousset09:30 Infection

Mark A. van Buchem10:00 Break10:20 Brain Tumors (General)

To be announced10:50 MRI of Intracranial Vascular

MalformationsKazuhiro Tsuchiya

11:20 MRI of EpilepsyKee-Hyun Chang

11:40 Pituitary and Parasellar DiseasesYukio Miki

12:00 Break

Pediatrics13:30 Metabolic Diseases of Children

Peter B. Barker14:00 Pediatric Tumors

Elias R. Melhem14:30 Newborn Brain Injury Imaging

Robert A. Zimmerman15:00 Adjournment

BRAIN FUNCTION AND fMRIPeter Jezzard, Douglas C. Noll, andSteve C.R. Williams, Organizers

Saturday, 10 May, 08:30 - 17:45 andSunday 11 May, 08:40 - 15:10

EDUCATIONAL OBJECTIVESUpon completion of the course, participantsshould be able to:� Identify the principal areas of the brain

used in sensory perception, motoractivity, language, and cognition;

� Describe the way in which these corticalareas inter-communicate, both at theelectrical and chemical level;

� Describe the associated hemodynamicresponses of the brain that accompanyelectrical and metabolic activity;

� Define and compare the various MRI pulsesequences that can be used to maphuman brain function;

� Identify the sources of artifacts that areinherent in many fMRI procedures anddescribe methods to minimize theseartifacts;

� Design a simple fMRI paradigm, anddescribe the principles used in dataanalysis;

� Explain the principles of perfusion basedfMRI and the methods used to constructmaps of white matter tracts;

� Identify the areas of application of fMRIin neurology, psychiatry and basicneuroscience.

PROGRAMDay 1: Saturday, 10 May08:30 Introduction

Course ChairsSession I: Functional Anatomy andConnectivity08:40 Grey Matter Functional

SpecializationArno Villringer

09:15 Fiber Tracts and StructuralConnectivity in the Human Brain:What Anatomy Can ContributeKarl Zilles

09:50 Neuronal Anatomy and ElectricalActivityNikos Logothetis

10:25 Break

14:15 Imaging Assessment of TumorResponseAnwar R. Padhani

15:00 Adjournment

Preliminary ProgramWEEKEND EDUCATIONAL PROGRAMS


14:35 Prepolarized MRISteven M. Conolly

Spin Physics and Dynamic Equilibrium inImaging15:00 Multidimensional RF Pulse Design

Peter Boernert15:25 Break15:45 The Phase-graph Concept for

Understanding Spin EchoesJürgen Hennig

16:10 Magnetization Vector Behavior inSSFP SequencesKlaus Scheffler

Advanced Image Reconstruction16:35 Introduction: from K-Space to

Image SpaceZhi-Pei Liang

17:00 Gridding Procedures for Non-Cartesian K-space TrajectoriesDouglas C. Noll

17:25 Artifacts and Correction AlgorithmsJoseph V. Hajnal

17:50 Adjournment

Sunday, 11 MayAdvanced Image Reconstruction08:00 Image Reconstruction from

Limited Data, General MethodsXiaoping Hu

08:25 Image Reconstruction fromLimited Data: MRA TechniquesWalter Block

Parallel Imaging Physics08:50 Foundations of Parallel Imaging

Peter Kellman09:15 Advanced Methods for Parallel

Imaging (Autocalibration,Adaptive Processing)Mark A. Griswold

09:40 Parallel Imaging ApplicationsDavid J. Larkman

10:05 Break10:25 Principles of RF Coil Design for

Parallel ImagingPatrick J. Ledden

Hardware10:50 Gradient Coil Design

Richard W. Bowtell11:15 Technical Considerations in

Developing High Field (>3T)SystemsJ. Thomas Vaughan

Applications with Special Pulse Sequencesand Processing11:40 Arterial Spin Labeling for

Perfusion MeasurementsDavid Alsop

12:05 Break13:35 Diffusion Tensor Imaging

Peter J. Basser

MR PHYSICS FOR PHYSICISTSMichael H. Buonocore, Peter M. Jakob, andJohn P. Mugler, III, Organizers

Saturday, 10 May, 08:30 - 17:50 andSunday, 11 May, 08:00 - 14:50

EDUCATIONAL OBJECTIVESUpon completion of the course, participantsshould be able to:� Describe the fundamental properties of

the NMR signal;� Explain the basic physics, signal process-

ing and instrumentation for signaldetection and image reconstruction;

� Describe the common and exotic mecha-nisms for spin polarization;

� Describe the spin physics and dynamicequilibrium that are used to create images;

� Describe advanced image reconstructionmethods, including those used in parallelimaging;

� Identify and describe special hardwareused in MRI;

� Describe pulse sequence and processingmethods for special applications.

PROGRAMDay 1: Saturday, 10 MaySignal Properties08:30 Quantum Mechanical Description of

Spin Dynamics and MagnetizationRobert W. Brown

08:55 Transition to the Semi-ClassicalDescriptionJames Tropp

09:20 Multiple-quantum Coherence,Intermolecular Spin OrdersJianhui Zhong

Basic Signal Detection and ImageReconstruction09:45 The MRI Receiver Chain

Steven M. Wright10:10 Break10:35 Signal Processing for MRI

Richard G.S. Spencer11:00 Measurements of Image Quality:

SNR, CNR, OptimizationDennis L. Parker

11:25 Field Dependence of PowerDeposition and SNRChristopher M. Collins

Mechanisms of Spin Polarization11:50 Hyperpolarization of Noble Gases:

Physical MethodsGordon Cates

12:15 Break13:45 Imaging Gases Under

Non-equilibrium ConditionsKai Ruppert

14:10 Polarization of Carbon-13Oskar Axelsson

Session II: Neurochemistry and MetabolicResponse10:45 Neurochemistry and Neuro-

transmitter SystemsKelvin O. Lim

11:20 Neuronal MetabolismNicola R. Sibson

11:55 Hemodynamic Responses toNeuronal ActivityRichard B. Buxton

12:30 Break

Session III: The BOLD Signal14:00 Sources of BOLD Signal/Field

Strength IssuesCharles S. Springer

14:35 Temporal BOLD Characteristicsand Non-LinearityDouglas C. Noll

15:10 Spatial Resolution LimitsRavi S. Menon

15:45 Break

Session IV: fMRI Pulse Sequences andArtifacts16:05 BOLD fMRI Sequences

Peter Jezzard16:40 Susceptibility Artifacts

Lawrence L. Wald17:15 Physiological/Intrinsic Noise and

Motion ArtifactsGunnar Krueger

17:45 Adjournment

Sunday, 11 MaySession V: Experimental Design and DataAnalysis08:40 Experimental Paradigm Design

Nick F. Ramsey09:15 Pre-Statistics

Stephen M. Smith09:50 Data Modeling, General Linear

Model, Statistical InferenceThomas E. Nichols

10:25 Break

Session VI: Non-BOLD Methods10:45 Functional Perfusion MRI

Eric C. Wong11:20 Connectivity Mapping Using DTI

Derek K. Jones12:00 Break

Session VII: Clinical and NeuroscienceApplications13:30 Design of a Clinical fMRI Protocol

Steve C.R. Williams13:55 fMRI of Neurological Disorders

Steven C. Cramer14:20 fMRI of Drug Abuse

Thomas Ernst14:45 Neuroscience Applications

John Jonides15:10 Adjournment

continued



RF BOOTCAMP:ESSENTIALS OF RF COIL DESIGN,CONSTRUCTION, AND INTERFACEH. Cecil Charles and Michael B. Smith,Organizers

Saturday, 10 May, 08:00 - 17:50

EDUCATIONAL OBJECTIVESUpon completion of the course, participantsshould be able to:

� Define inductance, capacitance, resonanceand distributed capacitance withreference to RF coils, their design andoperation;

� Describe the basic needs and componentsof a working RF laboratory;

� Compare design and construction of twoimportant types of coils;

� Explain the fundamentals of RF coilconnections to the scanner.

PROGRAM08:00 Welcome and Overview

H. Cecil Charles08:10 Basic Concepts I: Components

Steven M. Wright08:40 Basic Concepts II: Measurements

James R. MacFall09:10 The RF Laboratory

Randy Duensing10:00 Discussion

Team10:20 Break10:40 The Flat Circular Coil: Theory

H. Cecil Charles11:10 The Flat Circular Coil: Construction

H. Cecil Charles12:00 Break13:30 The Bird Cage Coil: Theory

Michael B. Smith14:15 The Bird Cage Coil: Construction

H. Cecil Charles15:00 Coil Interface: Theory and

ImplementationRandy Duensing

15:45 Break16:05 Where do We Go From Here?

Michael B. Smith16:45 Safety Issues

Daniel J. Schaefer17:30 Panel Discussion

Team17:50 Adjournment

CARDIAC IMAGINGDavid A. Bluemke, Vivian S. Lee, and EikeNagel, Organizers

Saturday, 10 May, 08:30 - 18:00


� Select the basic sequence type used forthe assessment of cardiac anatomy, leftventricular function and flow;

� List the current recognized indications incardiovascular imaging as well as todefine those under investigation;

� Appraise and critique the value of MR forthe assessment of ischemic heart disease;

� Interpret CMR examinations of cardiacmasses and ARVD;

� Describe the current value of MR imagingof the coronary arteries and atheroscleroticplaques and list its limitations;

� Determine left ventricular mass andfunction.

PROGRAMThe final five minutes of each presentationwill be reserved for questions.08:30 Understanding New Cardiac MR

Pulse SequencesJ. Paul Finn

09:05 MRI of Cardiac Valvular DiseaseChristopher M. Kramer

09:40 MRI of Global and RegionalLV FunctionAlbert C. van Rossum

10:15 Break10:35 MR Dobutamine Stress Testing

Eike Nagel11:10 MR Perfusion Imaging of Ischemia

Jürg Schwitter11:45 MRI of Myocardial Viability

Raymond J. Kim12:20 Questions/Summary12:30 Break14:00 MRI of Cardiac Masses and

PericardiumScott D. Flamm

14:35 MRI of ARVDDudley J. Pennell

15:05 MRI of LV CardiomyopathyRichard D. White

15:40 Break16:00 Coronary MR Angiography

Matthias Stuber

14:00 Velocity Measurement and FlowQuantificationNorbert J. Pelc

14:25 MR ElastographyArmando Manduca

14:50 Adjournment

16:35 MRI of Atherosclerotic DiseaseBruce A. Wasserman

17:10 MRI of Congenital Heart DiseasePhilip J. Spevak

17:45 Questions/Summary18:00 Adjournment

MR SPECTROSCOPY: BASICS ANDCLINICAL APPLICATIONSRoland Kreis and Daniel M. Spielman,Organizers

Saturday, 10 May, 08:30 - 18:00


� Describe fundamental principles ofclinical MR spectroscopy;

� Explain the crucial steps in performingand evaluating a MRS examination;

� Enumerate potential pitfalls in theclinical application of MR spectroscopy;

� Define diagnostic and patient manage-ment situations in which there is aclinically significant justification for aMRS examination;

� Summarize recent clinical uses of in vivoMRS.

PROGRAMThe final five minutes of each presentationwill be reserved for questions.

Introduction and Methodology08:30 Basics of MRS

Chris Boesch09:00 Localization Techniques

Markus von Kienlin09:30 Pre-scan and Shimming

Daniel M. Spielman10:00 Detectable Metabolites and Their

SignificanceOgnen A.C. Petroff

10:30 Break10:50 Data Processing + Fitting

Andrew A. Maudsley11:20 Quantitation + Artifacts in

Clinical MRSRoland Kreis

11:50 Discussion12:00 Break

Applications13:30 Tumors and Masses: Brain

Franklyn A. Howe14:00 Tumors and Masses: Prostate and

BreastJohn Kurhanewicz

14:30 Clinical MRS: MS and InflammationDavid H. Miller

15:00 Clinical MRS: EpilepsyKenneth D. Laxer

15:30 Break15:50 Clinical MRS: Psychiatry

Perry F. Renshaw16:20 Clinical MRS: Pediatrics

Petra Pouwels

Preliminary ProgramWEEKEND EDUCATIONAL PROGRAMS


MR OF TRANSGENIC MOUSE MODELS(“MR OMICS”)R. Mark Henkelman and Alan P. Koretsky,Organizers

Sunday, 11 May, 08:00 - 15:00


� Different ways in which molecularbiologists are using mouse models tounderstand development and disease;

� An overview of small animal imaging;applications of MR to mouse models ofcancer, neurological and cardiac diseases;

� How MR and mouse models are being usedfor drug discovery;

� Different approaches being taken to getmolecular information from small animalimaging techniques.

PROGRAM08:00 Mouse Models of Human Disease

Alexandra L. Joyner08:45 Overview of Small Animal Imaging

R. Mark Henkelman09:30 MR of Mouse Models of Neurological

DisordersJoseph A. Frank

10:15 Break10:45 MR of Mouse Models of Cardiac

DiseaseAxel Haase

11:30 MR of Mouse Models of CancerRobert J. Gillies

12:15 Break13:30 MR of Mouse Models for Drug

DiscoveryNicholas van Bruggen

14:15 Molecular/Cellular Imaging ofSmall AnimalsAlan P. Koretsky

15:00 Adjournment

MR SPECTROSCOPY: FRONTIERMETHODOLOGY AND APPLICATIONSRoland Kreis and Daniel M. Spielman,Organizers

Sunday, 11 May, 08:00 - 15:00

EDUCATIONAL OBJECTIVESUpon completion of the course, participantsshould be able to:� Describe fundamental principles on which

advanced uses of MRS are based;� List state-of-the-art techniques developed

for research applications of MR spectros-copy;

� Appraise advantages and pitfalls in the useof statistical tools to analyze MRS data;

� Summarize recent biomedical researchactivities involving in vivo MRS;

� Summarize issues of present-day method-ology and applications of high resolutionspectroscopy.


Methodology08:00 Fast CSI

Stefan Posse08:30 (De-)Coupling and Spectral Editing

Peter S. Allen09:00 Sophisticated RF Pulses for MRS

Robin A. de Graaf09:30 Statistical Tools for MRS Data

AnalysisWael El-Deredy

10:00 Discussion10:10 Break10:30 High Resolution NMR

Christian Griesinger

Advanced Applications11:20 In Vitro MRS

Stephen R. Williams11:50 Discussion12:00 Break13:30 High Field 1H-MRS

Rolf Gruetter14:00 In Vivo 13C and 15N MRS and Kinetic

AnalysisDouglas L. Rothman

14:30 MR Window on Tumor MetabolismRisto A. Kauppinen

15:00 Adjournment

SPORTS MEDICINE MRI:CLINICAL AND TECHNICAL UPDATEJohannes Bloem and Garry E. Gold, Organizers

Sunday, 11 May, 08:00 - 15:10

EDUCATIONAL OBJECTIVESUpon completion of the course, participantsshould be able to:� Use MRI findings to identify mechanisms of

joint injury and improve their diagnosisof sports-related abnormalities;

� Tailor MRI protocols for musculoskeletalinjuries;

� Explain the role of MR arthrography injoint imaging;

� Assess the role of MRI in musculoskeletalpractice;

� Distinguish trauma-related bone andmuscle injuries from neoplastic lesions;

� Determine the significance of findings onpost-operative MRI of the joints.

PROGRAM08:00 Pulse Sequences and Protocols

Garry Gold08:25 MRI of the Hip and Pelvis

Juerg Hodler08:50 MRI of the Elbow

Mark Schweitzer09:15 MRI of the Ankle

Douglas W. Goodwin09:40 Panel Discussion10:10 Break10:20 MRI of the Shoulder: Rotator Cuff

William E. Palmer10:50 MRI of the Shoulder: Labrum

Lynne S. Steinbach11:20 MRI of the Knee: Ligaments and

TendonsEugene G. McNally

11:50 MRI of the Knee: Menisci andCartilageKoenraad L. Verstraete

12:20 Panel Discussion12:30 Break13:30 Interventional Sports Imaging

Christopher F. Beaulieu14:00 Spine Imaging

Victor Pullicino14:30 Muscle Injuries

Robert D. Boutin15:00 Panel Discussion15:10 Adjournment

16:50 Clinical MRS: Ischemia, Hypoxia,Mitochondrial DiseasePeter B. Barker

17:20 Clinical 31P MRSDouglas L. Arnold

17:50 Discussion18:00 Adjournment

continued



Monday, 12 May, 09:00 - 10:15

IMAGING IN CHRONIC DISEASEGarry E. Gold, Clifford R. Jack, andJames F.M. Meaney, Organizers

EDUCATIONAL OBJECTIVESUpon completion of this session, participantsshould be able to:

� Recognize the role played by imaging inthe treatment and monitoring of chronicdiseases such as epilepsy, Alzheimers, andarthritis;

� Evaluate the advances in MRI that allowfor improved assessment of chronicdisease;

� Recommend new MRI techniques forstudying chronic disease at theirinstitution;

� Interpret new techniques, such asspectroscopy and T2-mapping, in theevaluation of chronic disease.

PROGRAM09:00 Future Directions in Funded

Biomedical Imaging ResearchRoderic I. PettigrewNational Institute for BiomedicalImaging and Bioengineering, NIHBethesda, Maryland, USA

09:25 Neurodegenerative Diseases andEpilepsyMichael WeinerUniversity of California atSan FranciscoSan Francisco, California, USA

09:50 The Burden of (Musculoskeletal)Disease: Challenges in Imagingfor Diagnosis and PrognosisMaarten BoersVU Medical Center,Amsterdam, The Netherlands

Tuesday, 13 May, 08:15 - 09:30

SAFETY AND MRIKim Butts, David J. Lomas, andMichael B. Smith, Organizers


� Identify the physiological limits of MRI;� Evaluate an epidemiological study on

MRI;

� Identify who makes recommendations onMRI guidelines;

� List MRI regulations.

PROGRAM08:15 Physiological Limits of MR

John SchenckGeneral Electric Corporate R&DSchenectady, New York, USA

08:40 MR Regulatory Bodies andRegulationsLoren A. ZarembaFood and Drug AdministrationRockville, Maryland, USA

09:05 Staying Below the Legal Limitsat Optimized MR SystemPerformanceFranz SchmittSiemens Medical Solutions,Massachusetts General HospitalNMR Center, Charlestown,Massachusetts, USA

Opening SessionMonday, 12 May

Welcome & Awards Ceremony07:45 - 08:20

2003 LAUTERBUR LECTURE:“The Legacy of I.I. Rabi”Norman F. Ramsey, Harvard University,Cambridge, Massachusetts, USA

08:20 - 09:00

Each year the ISMRM Scientific Meeting openswith the Lauterbur Lecture in recognitionof the contributions of Paul Lauterbur tothe field of magnetic resonance. At this11th Annual Meeting the lecture will focuson the legacy of Isadore Rabi, whose earlyobservations on molecular beam resonancewere fundamental to the development of ourfield and won him the Nobel Physics Prizein 1944. The lecture will discuss the manyfacets of Isadore Rabi and will be given byhis former PhD student and colleagueNorman Ramsey, who in 1989, also won theNobel Prize in Physics.

The Toronto Keynote Lecture“Future Directions in FundedBiomedical Imaging Research”Roderic I. Pettigrew, National Institute forBiomedical Imaging and Bioengineering,NIH, Bethesda, Maryland, USA

09:00 - 09:25

This year, in recognition of the establishmentin the United States of the first dedicatednational biomedical imaging institute,Dr. Roderic Pettigrew, the inaugural director,will present a keynote lecture outlining thefuture development of programs andinitiatives for biomedical imaging research.

Preliminary ProgramPLENARY SESSIONS


Wednesday, 14 May, 08:15 - 09:30

RF COILSPeter S. Allen, Rolf Gruetter, Michael B.Smith, and Daniel K. Sodickson, Organizers


� Understand the complexity and diversityof the evolution of coil design;

� Identify and explain the specificrequirements and challenges for coildevelopment at high fields;

� Describe the theory and implementationof parallel imaging.

PROGRAM08:15 A History of RF Coils

Eiichi FukushimaNew Mexico ResonanceAlbuquerque, New Mexico, USA

08:40 Development and Challenges ofHigh Field ResonatorsDavid I. HoultNational Research CouncilWinnipeg, Manitoba, Canada

09:05 Parallel MRI: Breaking theAcquisition Speed Limit UsingRF Coil ArraysJoseph HajnalImperial CollegeLondon, England, UK

Thursday, 15 May, 08:15 - 09:30

EVALUATION OF ISCHEMICHEART DISEASE BY MRIZahi A. Fayad, P.V. Prasad, and Martin R.Prince, Organizers


� Define current state of the art in theevaluation of ischemic heart disease byMRI;

� Select appropriate protocols for theevaluation of ischemic heart disease;

� Interpret MRI data used in the evaluationof ischemic heart disease;

� Appraise future developments in MRIapplications to the evaluation of ischemicheart disease;

� Recommend appropriate tests for theevaluation of ischemic heart disease byMRI.

PROGRAM08:15 Current State of the Art

Jan BogaertUniversity HospitalsLeuven, Belgium

08:40 What’s on the HorizonCharles B. HigginsUniversity of California atSan FranciscoSan Francisco, California, USA

09:05 What Does the Future Behold?Elliot R. McVeighJohns Hopkins School of MedicineBaltimore, Maryland, USA

Friday, 16 May, 08:15 - 09:30

THE TUMORMICROENVIRONMENTJeffrey L. Evelhoch, John R. Griffiths, andMichal Neeman, Organizers


� Describe several key physiological aspectsof the tumor microenvironment andexplain why it is important to be able toassess them;

� List several MRI, MRS and EPR methodswhich have been used to examine keyaspects of the tumor microenvironmentalpathophysiology;

� Explain how results of studies using thesemagnetic resonance methods haveimpacted our understanding of tumormicroenvironmental pathophysiology.

PROGRAM08:15 Mechanisms Underlying Tumor

MicroenvironmentalPathophysiologyMark W. DewhirstDuke University Medical CenterDurham, North Carolina, USA

08:40 MRI and MRS Studies of TumorPathophysiologyRobert J. GilliesUniversity of ArizonaTucson, Arizona, USA

09:05 EPR Studies of Tumor OxygenationBernard GallezUniversité‚ Catholique de LouvainBrussels, Belgium.

PLENARY SESSIONSPreliminary Program


CONTROVERSIES AND ADVANCES INMUSCULOSKELETAL MRIGarry E. Gold and Lawrence M. White,Organizers

EDUCATIONAL OBJECTIVESUpon completion of this course, participantsshould be able to:� Compare MRI with other advanced

imaging modalities;� Explain the role of interventional MRI in

the musculoskeletal system;� Explain the role of High Field MRI in the

musculoskeletal system;� Describe the technical issues related to

high-resolution joint imaging;� Evaluate options for open MRI scanners

for musculoskeletal imaging.

PROGRAMTuesday, 13 May07:00 High Field MRI: Technical Issues

William E. Palmer07:25 High Field MRI: Clinical Issues

Timothy J. Mosher07:50 Questions and Discussion

Wednesday, 14 May07:00 Interventional MRI:

Technical IssuesKim Butts

07:25 Interventional MRI:Clinical IssuesJohn A. Carrino

07:50 Questions and Discussion

Thursday, 15 May07:00 CT vs MRI in the Postoperative

Joint: Technical IssuesJoshua M. Farber

07:25 CT vs MRI in the PostoperativeJoint: Clinical IssuesLawrence M. White

07:50 Questions and Discussion

Friday, 16 May07:00 Cartilage MRI: Technical Issues

Brian A. Hargreaves07:25 Cartilage MRI: Clinical Evaluation

Russell C. Fritz07:50 Questions and Discussion

Tuesday, 13 May - Friday 16 May, 07:00 - 08:00

PARALLEL IMAGINGNeil M. Rofsky and Daniel K. Sodickson,Organizers

EDUCATIONAL OBJECTIVESUpon completion of this course, participantsshould be able to:� Explain the basic principles of parallel

imaging, including elements both of RFcoil array design and image reconstruction;

� Survey promising applications of parallelMRI in cardiovascular imaging and bodyimaging;

� Describe new developments in image recon-struction and coil array design, and outlineemerging parallel imaging applications;

� Identify the key steps in a practical parallelimaging examination, and compare thenuts-and-bolts features of various MRvendors’ existing implementations.

PROGRAMTuesday, 13 MayBasics07:00 Introduction

Daniel K. Sodickson07:05 Coil Arrays

(The Technological Tools)Josef H. Duyn

07:30 Image Reconstruction(The Mathematical Tools)Klaas Prüssmann

07:55 Discussion

Wednesday, 14 MayApplications07:00 Recap of Basics

Daniel K. Sodickson07:05 Cardiovascular Imaging

Peter Boesiger07:30 Body Imaging

Neil M. Rofsky07:55 Discussion

Thursday, 15 MayNew Developments07:00 Recap of Basics and Applications

Daniel K. Sodickson07:10 New Developments in Image

Reconstruction and SequenceDesignCharles A. Mckenzie

07:35 New Developments in ArrayDesign and New ApplicationsDavid J. Larkman

Friday, 16 MayVendor Implementations07:00 Recap of Basics, Applications,

and New DevelopmentsDaniel K. Sodickson

07:10 Philips Medical SystemsScott D. Flamm

07:25 GE Medical SystemsRobert R. Edelman

07:40 Siemens Medical SolutionsStefan O. Schoenberg

07:55 Discussion and Conclusion

EMERGING BODY MR:FROM STRUCTURE TO FUNCTIONVivian S. Lee and Riccardo Manfredi,Organizers

EDUCATIONAL OBJECTIVESUpon completion of this course, participantsshould be able to:� Recognize and implement recent technical

advances in body MRI including BOLD andperfusion techniques, fast T2-weightedimaging methods, and new contrastagents;

� Describe recent advances in the assess-ment of liver and breast for tumor,structural and functional studies of thebiliary system, and MR measurements ofrenal function;

� Identify applications of MR to theevaluation of large and small boweldisease;

� Compare the information provided by MRelastography in the assessment of organpathologies, such as in the breast andprostate, against conventional MRimaging techniques.

PROGRAMTuesday, 13 MayTechnical Developments07:00 Perfusion MRI and BOLD Techniques

P.V. Prasad07:20 Fast T2 Imaging Techniques

Stefan G. Ruehm07:40 New Contrast Agents

Carlo Bartolozzi

Wednesday, 14 MayHepatobiliary Imaging07:00 Liver MRI: Anatomic and

Perfusion ImagingGlenn A. Krinsky

07:30 MRCP/Pancreas MRICarlo Procacci

Thursday, 15 MayGenitourinary07:00 Functional Kidney MRI

Thomas M. Grist07:30 MR Elastography:

Prostate and BreastRichard L. Ehman

Friday, 16 MayBreast and Bowel07:00 Breast

Christiane K. Kuhl07:20 MRI of the GI Tract: Small Bowel

Taro Takehara07:40 MRI of the GI Tract: Colon

Jörg F. Debatin

MORNING CATEGORICAL COURSESPreliminary Program



fMRI EXPERIMENTAL METHODSR. Todd Constable and Mathias Hoehn,Organizers

EDUCATIONAL OBJECTIVESUpon completion of this course, participantsshould be able to:

� Explain the latest developments in fMRIwith respect to understanding theunderlying physiology leading to theBOLD response and it’s relationship toneuronal activity, and the influence ofpharmacological substances on activation;

� Describe the factors influencing paradigmdesign and the optimum acquisitionstrategy for event related versus blockdesigns;

� Recognize which analysis approach ismost appropriate for a particular experi-mental design;

� Describe the spatial limits of fMRI andfactors influencing resolution.


Tuesday, 13 MayPhysiological Changes07:00 Physiological Changes Associated

with Neuronal ActivationRichard Hoge

07:30 Neuronal Activity/TemporalResolution and fMRINikos Logothetis

Wednesday, 14 MayExperimental Design(Paradigms/Acquisition Strategies)07:00 Paradigm Design Issues: Event-

related vs. Block DesignRasmus M. Birn

07:30 Acquisition Strategies/PulseSequencesXiaoping P. Hu

Thursday, 15 MayData Analysis07:00 Model-Driven Analysis

Keith J. Worsley07:30 Exploratory Data Analysis

James J. Pekar

Friday, 16 MaySpatial Temporal Resolution Limitations07:00 Pharmacological Modulations of

fMRIMathias Hoehn

07:30 Spatial Resolution IssuesR. Todd Constable

DIFFUSION TENSOR IMAGINGGareth J. Barker and Scott D. Swanson,Organizers


� Describe how and why the protondiffusion pathway in tissue can beexplained by a tensor;

� Explain how the tensor is acquired,measured and mapped;

� Understand the limitations of suchdiffusion tensor imaging;

� Describe more advanced diffusion measure-ment techniques such as q-space and dif-fusion spectrum imaging;

� Appreciate the multi-exponential and/ormulti-compartmental nature of diffusion;

� List and describe important clinicalapplications of DTI.

PROGRAMTuesday, 13 May07:00 Introduction and Background

Peter Basser

Wednesday, 14 May07:00 Dealing With Tensors

Derek K. Jones

Thursday, 15 MayResearch Frontiers in DTI07:00 Multiexponential Decay

Greg J. Stanisz07:30 Beyond Tensor Imaging

Daniel Alexander

Friday, 16 May07:00 Clinical and Medical Applications

of DTICarlo Pierpaoli

ADVANCED MR ANGIOGRAPHYTECHNIQUESJames F.M. Meaney, Martin R. Prince, andStefan O. Schoenberg, Organizers

EDUCATIONAL OBJECTIVESUpon completion of this course, participantsshould be able to:� Identify the challenges of MRA implemen-

tation in anatomic areas with hightechnical demands;

� Compare the advantages and disadvan-tages of different technical approaches inthese areas;

� Recognize the clinical benefit of advancedMRA protocols for a comprehensive non-invasive work-up of vascular disease.

PROGRAMTuesday, 13 MayOptimizing MRA in the Feet07:00 2D Projection MRA

Neil Khilani07:10 3D Tricks

Barry Stein07:20 Moving Table: Sagittal Feet

Jeffrey H. Maki07:30 Moving Table: Coronal Feet

James F.M. Meaney07:40 Discussion

Wednesday, 14 MayRenal Artery Stenosis Grading Shoot-Out07:00 3D Phase Contrast

Martin R. Prince07:10 2D Cine PC Flow Curves

Stefan O. Schoenberg07:20 Gadolinium Clearance Rate

Thomas M. Grist07:30 Captopril MR Renography

P.V. Prasad07:40 Discussion

Thursday, 15 MayApproaches to Total Body MRA07:00 Angiosurf

Stefan G. Ruehm07:15 Continuous Table Motion

David G. Kruger07:30 Jumping VIPR with Continuous

Table MotionSean B. Fain

07:45 Discussion

Friday, 16 MayCoronary Shoot-Out07:00 Navigator

Warren J. Manning07:15 Radial Image Breath-Hold

Debiao Li07:30 Multi-Detector CTA Versus MRA

of the CoronariesKonstantin Nikolaou

07:45 Discussion

Preliminary ProgramMORNING CATEGORICAL COURSES


CARDIOVASCULAR MRIZahi A. Fayad, Christopher Kramer andP.V. Prasad, Organizers

TWO-SESSION COURSE:Monday, 12 May, 11:00 - 13:00 andThursday, 15 May, 10:30 - 12:30


� Describe basic areas of routine andpromising clinical use of MR in assessingcardiovascular disease;

� Apply MR protocols for determination ofcardiac morphology, dynamic function,flow, and physiologic status;

� Describe methodologies that help in theinterpretation of results for cardiac MRassessment of acquired and congenitalcardiac disease;

� Compare approaches for optimal presenta-tion and analysis of cardiac MR results.

PROGRAMMonday, 12 MaySession I11:00 Introduction to Cardiac MR

Jörg Barkhausen11:25 Assessment of Myocardial

Function, Rest, and StressEike Nagel

11:50 MR Coronary AngiographyAlbert de Roos

12:15 Atherosclerotic PlaqueCharacterizationChun Yuan


Thursday, 15 MaySession II10:30 Fast Imaging and Real-Time

Cardiac MRIFrederick H. Epstein

10:55 Assessing Myocardial PerfusionSteven D. Wolff

11:20 Cardiovascular MRI in PulmonaryHypertensionMichael Poon

11:45 Determining Myocardial ViabilityJoao A.C. Lima


SPECTROSCOPY BEYOND NAAPeter S. Allen, John R. Griffiths, RolfGruetter, and Stephen R. Williams, Organizers


� List the major metabolites in addition toNAA, Cr, Cho that can be detectedin vivo in the brain by MRS;

� Describe the biological and clinical impor-tance of these metabolites;

� List the key factors to achieve good spectra;

� Describe the principles of data analysis inboth frequency and time domain;

� Explain how MRS can be used to measuremetabolic fluxes as well as steady stateconcentrations;

� List the advantages and disadvantages of13C/15N with respect to 1H.

PROGRAMTuesday, 13 May07:00 Introduction

Stephen R. Williams07:30 Macromolecules, GABA and Editing

Kevin L. Behar

Wednesday, 14 May07:00 Time-Domain Based Analysis

Danielle Graveron-Demilly07:30 LC Model Applications at High Field

Ivan Tkac

Thursday, 15 May07:00 1H MRS at 1.5/2T

Petra Pouwels07:30 Potential and Promise of 15N NMR

Keiko Kanamori07:45 13C MRS at 1.5T

Stefan Bluml

Friday, 16 May07:00 13C NMR: Past and Present

Peter G. Morris07:30 Indirect Detection of 13C

Label/Editing at 3TGilles F. Bloch

HIGH FIELD NEUROIMAGINGClifford R. Jack and Christiane K. Kuhl,OrganizersTuesday, 13 May, 10:30 - 12:30

EDUCATIONAL OBJECTIVESUpon completion of this course, participantsshould be able to:� List the advantages and disadvantages of

high field (3-4T) vs. systems ≤ 1.5T forclinical neuroimaging;

� Describe which clinical neuroimagingapplications are likely to benefitsubstantially from high field (3-4T);

� Recognize which clinical neuroimagingapplications are unlikely to see a majorperformance improvement at 3-4T vs. ≤1.5T.

PROGRAMThe final five minutes of each talk will bereserved for questions.10:30 3T Neuro MRI in a Clinical Setting:

Benefits and LimitationsChristiane K. Kuhl

11:00 Clinical 3T Neuroimaging: MRAMatt A. Bernstein

11:30 BOLD Surgical Planning at 3TKeith R. Thulborn

12:00 Clinical DTI at 3TXiaohong J. Zhou

12:30 Adjournment

INTERVENTIONAL MRIKim Butts and Thomas Kahn, OrganizersWednesday 14 May, 10:30 - 12:30

EDUCATIONAL OBJECTIVESUpon completion of this course, participantsshould be able to:� List procedures that can be enabled or

improved with MRI guidance;� List devices that are MR-compatible and

commercially available;� Recognize desired areas of further

technical innovation.

PROGRAMWady M. Gedroyc and Ferenc Jolesz,Co-Moderators

10:30 Percutaneous ProceduresJonathan Lewin

10:55 Intraoperative ProceduresCharles L. Truwit

11:20 Thermal AblationsThomas Vogl

11:45 Vascular InterventionsJörg F. Debatin

12:10 Panel Discussion:Requirements for WidespreadAdoption

12:30 Adjournment

CLINICAL CATEGORICAL COURSESPreliminary Program

MORNING CATEGORICAL COURSES



IMAGING IN DRUG DEVELOPMENTJeffrey L. Evelhoch and John R. Griffiths,OrganizersWednesday, 14 May, 10:30 - 12:30


� Identify the key objectives of an MR studyin development of a given drug;

� Explain why MR methodology studies(e.g. reproducibility, validation) shouldprecede deployment of MR in clinicaltrials of novel therapy;

� Recommend MR protocols for use in drugdevelopment; explain how and why thesediffer from protocols used in routinediagnostic practice;

� Recognize the impact of Good ClinicalPractice regulations in the MR study, andadvise physicist and physician co-workersaccordingly.

PROGRAMDavid S. Lester and Steve C.R. Williams,Moderators

10:30 The Emerging Role of MR in DrugDevelopmentJohn C. Waterton

10:50 Imaging and Neurological DrugDevelopmentSteven Warach

11:10 Imaging and Cardiovascular DrugDevelopmentChun Yuan

11:30 Imaging and Oncologic DrugDevelopmentPatricia Cole

11:50 Imaging and Arthritis DrugDevelopmentCharles G. Peterfy

12:10 What Radiologists Need to KnowAbout Roles and Rules inClinical TrialsRichard P. Jacobs

12:30 Adjournment

SMRT FORUM:MR PURCHASE DECISIONSNanette Keck, OrganizerMonday, 12 May, 14:00 - 16:00


� Describe the various types of MR systemsavailable today;

� List the major differences between systems;

� Describe the advantages and disadvantages ofeach;

� Explain how various system componentsimpact MR image quality;

� Explain the system requirements forvarious types of MR procedures.

PROGRAM TOPICS1. Analytic Approach to Equipment,

Finances, Compatibility, Site Preparation,PACs, and Delivery.

2. High- vs. Low-field.3. Coil Considerations.4. Dedicated vs. Whole Body Systems.5. 3T.

Speakers: William Faulkner, Gary C. Glover,Herbert Y. Kressel, and James J. Stuppino.

MR PHYSICS AND TECHNIQUES FORCLINICIANSFrank R. Korosec and Joseph G. McGowan,OrganizersMonday, 12 May, 16:30 - 18:30,Tuesday, 13 May, throughThursday, 15 May, 16:00 - 18:00

EDUCATIONAL OBJECTIVESUpon completion of this course, participantsshould be able to:� Define and describe the fundamental

principles of MR imaging, including thedefinition of spin magnetization, theLarmor relationship, relaxation phenom-ena, and the process of using the spinmagnetization to produce an image;

� Explain imaging pulse sequences basedupon spin and gradient echoes, includingfast spin echo and echo planar tech-niques;

� Design MR imaging protocols for diagnos-tic applications considering imagecontrast, spatial resolution, acquisitiontime, signal-to-noise ratio, and artifacts;

� Describe the principles and capabilitiesof various advanced MR techniquesincluding diffusion, cardiac andfunctional MRI, and spectroscopy.

HOT TOPICS FOR CLINICAL PRACTICEThomas M. Grist and Clifford R. Jack,OrganizersTuesday, 13 May, 13:30 - 15:30

EDUCATIONAL OBJECTIVESUpon completion of this course, participantsshould be able to:� Describe five points that can be used to

improve imaging strategies in importantareas of clinical practice;

� Assess the applicability to clinicalpractice of three newer imaging tech-niques.

PROGRAMIt is the intention of the organizers thatthis course cover the most current clinicalquestions and controversial areas, andinclude the most up-to-date informationavailable. Therefore, the final selection ofsubjects and speakers for the Hot TopicsCourse is not made until a date much laterthan for the other courses at the meeting,and at this time we don’t yet have specificdetails. Please check the ISMRM Websiteperiodically for news of the course program.

PROGRAMMonday, 12 May16:30 Spin Gymnastics I

Walter Kucharczyk andDonald B. Plewes

17:10 Spin Gymnastics IIWalter Kucharczyk andDonald B. Plewes

17:50 SpectroscopyJack Knight-Scott

Tuesday, 13 May16:00 Spin Echo Imaging

Bruce Pike16:40 Gradient Echo Imaging

John P. Mugler, III17:20 Fast Spin Echo Imaging

Joseph C. McGowan

Wednesday, 14 May16:00 Image Quality and Acquisition

SpeedNorbert J. Pelc

16:40 Ultrafast ImagingMarcus Alley

17:20 Diffusion ImagingKonstantinos Arfanakis

Thursday, 15 May16:00 Cardiac MRI

Frank R. Korosec16:40 Functional MRI

M. Elizabeth Meyerand17:20 Hardware

Richard G.S. Spencer

Preliminary ProgramOTHER PRACTICAL COURSES


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Student Stipend Check Sheet

SEND COMPLETED CHECK SHEET AND ALL MATERIALS TO:Joseph V. Hajnal, Ph.D., ChairInternational Society for Magnetic Resonance in MedicineSubcommittee on Student Stipends2118 Milvia Street, Suite 201Berkeley, California 94704, USA

Applicant Name _____________________________________________

Degree____________________________________________________

Mailing Address _____________________________________________

_____________________________________________________________________

City ______________________________________________________

State/Province______________________________________________

Country ___________________________________________________

Postal Code/Zip+4 ___________________________________________

Contact Phone Number ______________________________________

Home Phone Number ________________________________________

E-mail Address ______________________________________________

Supervisor _________________________________________________

I have previously applied for a student stipend. □ YES □ NO

If yes, state the year(s) you have received support ________________

__________________________________________________________

Have you submitted an Abstract to the ISMRM as the first author?□ YES □ NO

What is the typical lowest airfare from your city to Toronto?

(US$) __________

□ DO NOT release my CV to corporate sponsors.

Recipients of Student Stipends will be required to submit an applica-tion for membership in the ISMRM before the funds are disbursed.

ENCLOSED:

□ Student’s Application Letter□ Student’s Curriculum Vitae□ Abstract and confirmation of online submission□ Supervisor’s Letter□ Eligibility Verification□ Membership Application (for nonmembers only)

The ISMRM invites applications for educational stipends that offersupport for the attendance of students, postdoctoral and clinicaltrainees to present abstracts at the Eleventh Scientific Meeting.To be eligible for support, an applicant should either be (1) enrolledin a full-time under-graduate or graduate program or (2) a medicalintern, first-, second-, or third-year resident, or a postdoctoraltrainee who received a doctorate or equivalent degree after 31 July1999. Those applicants who are first authors on the abstract will begiven priority. Recipients of educational stipends who are notmembers of the ISMRM will be required to submit an application formembership before the funds are disbursed. Stipend recipients arelimited to three years of support.

HOW TO APPLY:Applicants for support should submit the following:

� Printout of the electronically submitted abstract;

� Copy of email confirming online submission;

� A letter from the applicant requesting student/postdoctoralsupport and confirming his/her intention to attend themeeting;

� A curriculum vitae of the applicant;

� A supervisor’s or sponsor’s letter confirming the applicant’seligibility for a student stipend. The Committee requests thatthe letter include comments on available funds for support.If a number of applicants from the same group are applying,the Committee would appreciate a unique comment on eachapplicant, since funding might be limited in this situation;

� Completed check sheet.

WHERE TO APPLY:Joseph V. Hajnal, Ph.D., ChairInternational Society for Magnetic Resonance in MedicineSubcommittee on Student Stipends2118 Milvia Street, Suite 201Berkeley, California 94704, USA

DEADLINE:Applications must be received no later than 20 November 2002.

Educational Stipends for Studentsand Postdoctoral Trainees

FOR OFFICE USE ONLY

CONFIRMATION NO. DATE RECEIVED


Clinical Resident Stipend Check Sheet

SEND COMPLETED CHECK SHEET AND ALL MATERIALS TO:Joseph V. Hajnal, Ph.D., ChairInternational Society for Magnetic Resonance in MedicineClinical Resident Stipend Committee2118 Milvia Street, Suite 201Berkeley, California 94704, USA

Applicant Name _____________________________________________

Degree_____________________________________________________

Mailing Address _____________________________________________

___________________________________________________________

City _______________________________________________________

State/Province ______________________________________________

Country ___________________________________________________

Postal Code/Zip+4 ___________________________________________

Contact Phone Number _______________________________________

Home Phone Number _________________________________________

E-mail Address ______________________________________________

Supervisor __________________________________________________

Recipients of Clinical Resident stipends will be required to submit anapplication for membership in the ISMRM before the funds aredisbursed.

ENCLOSED:□ Clinical Resident’s Application Letter

□ Clinical Resident’s Curriculum Vitae

□ Department Chair’s Letter

□ Eligibility Verification

□ Membership Application (for nonmembers only)

Recognizing the need to involve greater numbers of newly trainedphysicians in the science and clinical application of magnetic resonance,this stipend award has been set up to encourage young clinicians in thisfield of study. Each awardee will receive US$400 toward the costs ofattending the Eleventh Scientific Meeting in Toronto, Ontario, Canada.In addition, each awardee will be paired with a senior member of theISMRM who will be the awardee’s mentor during the Scientific Meeting,providing the opportunity for daily reviews and discussions of importantscientific and clinical developments presented at the meeting. Recipientsof stipends who are not members of the ISMRM will be required tosubmit an application for membership before funds are disbursed.

ELIGIBILITY CRITERIA:� Applicants must be actively enrolled in a clinical residency

(i.e., clinical training) program;

� Applicants cannot be first or presenting authors on abstractssubmitted to the ISMRM program and do not need to submit anabstract to the meeting;

� Applicants are required to attend at least 4 days of the ISMRMmeeting, including at least one day of the weekend educationalcourses.

PROGRAM DESCRIPTION:� Awardees will be paired with a clinical mentor from the ISMRM

community, with whom they will meet on a daily basis.

� Awardees will prepare a review of their meeting experiences that willbe sent to the mentor within six weeks of the Scientific Meeting.

� Mentors will subsequently be available to the awardees for adviceand discussion regarding scientific and career issues in the field ofmagnetic resonance.

APPLICATION PROCEDURE:� Applicants should send a letter including a brief statement of their

interest in attending the Scientific Meeting and explaining why theyare interested in the field of magnetic resonance;

� A letter of support from the Department Chair is required statingthat the resident either will be given the time off from clinicalduties to attend and be supported for the remaining cost of themeeting, or will use vacation time and personal funds as needed;

� A curriculum vitae of the applicant must accompany the application;


WHERE TO APPLY:Joseph V. Hajnal, Ph.D., ChairInternational Society for Magnetic Resonance in MedicineClinical Resident Stipend Committee2118 Milvia Street, Suite 201Berkeley, California 94704, USA


Clinical Resident Stipend Award

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FOR OFFICE USE ONLY

ID NO. DATE RECEIVED


New Entrant Stipend Check Sheet

SEND COMPLETED CHECK SHEET AND ALL MATERIALS TO:Joseph V. Hajnal, Ph.D., ChairInternational Society for Magnetic Resonance in MedicineNew Entrant Stipend Committee2118 Milvia Street, Suite 201Berkeley, California 94704, USA

Applicant Name _____________________________________________

Degree_____________________________________________________

Mailling Address _____________________________________________

__________________________________________________________

City _______________________________________________________

State/Province ______________________________________________

Country ____________________________________________________

Postal Code/Zip+4 ____________________________________________



E-mail Address ______________________________________________

Supervisor __________________________________________________

Recipients of clinical New Entrant stipends will be required to submitan application for membership in the ISMRM before the funds aredisbursed.

ENCLOSED:□ New Entrant’s Application Letter

□ New Entrant’s Curriculum Vitae

□ Department Chair’s Letter

□ Eligibility Verification

□ Membership Application (for nonmembers only)

To encourage new entrants to research in areas of interest to the ISMRM,the Society invites applications for a New Entrant Stipend Award. Thisprogram is aimed at students or researchers who are new to the field andmight not be funded under the main educational stipend program. Eachawardee will receive US$400 toward the costs of attending the EleventhScientific Meeting in Toronto, Ontario, Canada. In addition, eachawardee will be paired with a senior member of the ISMRM who will bethe awardee’s mentor during the Scientific Meeting, providing theopportunity for reviews and discussions of important scientific andclinical developments presented at the meeting. Recipients of stipendswho are not members of the ISMRM will be required to submit anapplication for membership before funds are disbursed.

ELIGIBILITY CRITERIA:� Applicants must be already actively involved or about to be actively

involved in some aspect of research related to the ISMRM;

� Applicants cannot be first or presenting authors on abstractssubmitted to the ISMRM program and do not need to submit anabstract to the meeting;

� Applicants are required to attend at least 4 days of the ISMRMmeeting, including at least one day of the weekend educationalcourses.

PROGRAM DESCRIPTION:� Awardees will be paired with a mentor from the ISMRM community,

with whom they will meet on a daily basis.

� Awardees will prepare a review of their meeting experiences that willbe sent to the mentor within six weeks of the Scientific Meeting.

� Mentors will subsequently be available to the awardees for adviceand discussion regarding scientific and career issues in the field ofmagnetic resonance.

APPLICATION PROCEDURE:� Applicants should send a letter including a brief statement of their

interest in attending the Scientific Meeting and explain how this willrelate to their own work;

� A letter of support from the Department Chair is required statingthat the student either will be given the time off to attend and besupported for the remaining cost of the meeting, or will use vacationtime and personal funds as needed;

� A curriculum vitae must accompany the application;


WHERE TO APPLY:Joseph V. Hajnal, Ph.D., ChairInternational Society for Magnetic Resonance in MedicineNew Entrant Stipend Committee2118 Milvia Street, Suite 201Berkeley, California 94704, USA


New Entrant Stipend Award

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FOR OFFICE USE ONLY

ID NO. DATE RECEIVED


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E.K. Zavoisky Stipend Check Sheet

SEND COMPLETED CHECK SHEET AND ALL MATERIALS TO:Donald M. Hadley, M.B., Ch.B., Ph.D., ChairInternational Society for Magnetic Resonance in MedicineE.K. Zavoisky Stipend Committee2118 Milvia Street, Suite 201Berkeley, California 94704, USA

Applicant Name _____________________________________________

Degree_____________________________________________________

Mailing Address _____________________________________________

___________________________________________________________

City _______________________________________________________

State/Province ______________________________________________

Country ____________________________________________________

Postal Code/Zip+4 ____________________________________________



E-mail Address _______________________________________________

Supervisor __________________________________________________

Have you submitted an Abstract to the ISMRM as the first author?

□ YES □ NO

What is the typical lowest airfare from your city to Toronto?

(US$) _______________

ENCLOSED:□ E.K. Zavoisky Program Application Letter

□ Curriculum Vitae

□ Abstract and confirmation of online submission

□ Supervisor’s Letter

The ISMRM invites applications for stipends from the E.K. ZavoiskyProgram, established to support the attendance of scientists andclinicians at the ISMRM Eleventh Scientific Meeting. The program isnamed in honor of E.K. Zavoisky, pioneer in MR research from theformer USSR (see below). The purpose of the program is to supportscientists and clinicians who do not have access to the financial meansto attend the ISMRM Eleventh Scientific Meeting. Applicants eligiblefor the Educational Stipend Program (undergraduate and graduatestudents and postdoctoral and medical trainees) are not eligible forthe Zavoisky Program. Those applicants who are first authors on theAbstract submission will be given priority.

APPLICATION PROCEDURE:Applicants for support should submit the following:

� A printout of the electronically submitted abstract;

� Copy of email confirming online submission;

� A letter of application;

� A curriculum vitae;

� A letter from an appropriate person at their institution(supervisor, head of department, etc.) certifying that noalternative funds are available. If a number of applicantsfrom the same institution are applying, the Committee wouldappreciate a unique comment on each, since funding mightbe limited in this situation.


WHERE TO APPLY:Donald M. Hadley, M.B., Ch.B., Ph.D., ChairInternational Society for Magnetic Resonance in MedicineE.K. Zavoisky Stipend Committee2118 Milvia Street, Suite 201Berkeley, California 94704, USA


About E.K. ZavoiskyE.K. Zavoisky, from Kazan, Tatarstan, is nowadays acknowledgedas the inventor of Electron Spin Resonance. There is also strongsupport for the thesis that he was the first to observe a NMR signalas early as 1941, but he could not detect the signal reproduciblywith the very basic apparatus he was able to build with the limitedmeans available to him.Due to the political situation at that time, Zavoisky´s workremained largely unnoticed in the west. Although unquestionablythe first to observe spin resonance, the Nobel Prize Committee didnot further consider his contribution due to the lack of follow-uppapers and his move to other fields.

It is interesting to note that the CV of Zavoisky explicitly reportshis first trip to an international conference (1961). There is littledoubt that the history of spin resonance would be seen from adifferent perspective if Zavoisky had been able to pursue his workwithin the awareness of an international scientific community.

It seems, therefore, to be more than appropriate to name a programestablished to help scientists from around the world to communicatetheir achievements in the memory of E.K. Zavoisky.

E.K. Zavoisky Stipend Program

FOR OFFICE USE ONLY

CONFIRMATION NO. DATE RECEIVED


The SMRT Policy Board and ExecutiveCommittee have been quite busysince our Annual Meeting in Hawai’i.

After gathering comments and suggestionsfrom the SMRT meeting attendees, we arein the process of implementing new ideasinto the SMRT.

In this “SMRT Update,” I would like tointroduce the ISMRM members to the SMRTCommittees.

The SMRT Executive Committee iscomprised of John Koveleski, President(Pennsylvania); Heidi Berns, Past-President(Iowa); Maureen Ainslie, President Elect(North Carolina); Anne Sawyer-Glover,Treasurer (California); Bill Faulkner,Secretary (Tennessee); Maureen Hood,Executive Liaison (Maryland); and NanetteKeck, Executive Member (Utah). TheExecutive Committee has a wealth ofknowledge and experience involving MRIand all of the SMRT activities.

Anne Sawyer-Glover, from StanfordUniversity, as SMRT Treasurer is the Chair ofthe Finance Committee. Anne’s attention todetail is outstanding. As treasurer thereare many aspects of detail in the budgetingprocess, as well as all the oversight neededin order to meet SMRT financial goals. Annewas very successful in raising fundsnecessary to offset the expenses of theSMRT Annual Meeting in Hawai‘i. We arelooking forward to her expertise infundraising for the Toronto meeting.

Maureen Hood, from the UniformedServices University, in Bethesda, Maryland,heads our External Relations Committee.Maureen is busy interacting with otherorganizations as the SMRT representative.The SMRT is a member of the HealthProfessions Network, Maureen will berepresenting SMRT at the upcoming meetingin Madison, Wisconsin. In addition, we’verecently created a subcommittee focused onGlobal Development. Muriel Cockburn, fromGlasgow, Scotland, is working with Maureenon this newly developed subcommittee.Muriel is the Past-President of the BritishAssociation of MR Radiographers (BAMRR)and will act as a liaison between the SMRTand other MR technologist organizationsthroughout the world.

Laurian Rohoman, from MontrealGeneral Hospital, Montreal, Canada, is ourProgram Chair for the 2003 Annual Meetingto be held in Toronto. Laurian and theProgram Committee have been hard at worksince the Honolulu Annual Meetingdeveloping the agenda and speaker list forthe Toronto meeting. Topics will bepresented on the latest updates in cardiac

From The SMRT Presidentimaging, breast imaging, pelvic imaging,contrast agents, musculoskeletal imaging,pediatrics, stroke/DWI/PWI, functionalimaging, pulse sequences, and sedation.SMRT is fortunate to have outstandingfaculty willing to donate their time andshare their knowledge with MR technologists.

Julie Lowe, from Indianapolis, Indiana,is the Education Committee Chair. Julie hastaken on an enormous task and has donevery well with this extremely busy commit-tee. She is working with Laurian indeveloping the Toronto program, as well aspreparing her committee for the process ofthe abstract review and scoring. The SMRTis strongly encouraging technologists tosubmit abstracts and to be a part of theprogram in Toronto. We are lookingforward to having total electronic abstractsubmission again this year.

Heidi Berns, from Iowa City, Iowa, isthe Chair of the Nominations and AwardsCommittee. Heidi has solicited the namesof candidates for the SMRT Policy Boardelections, to be held this fall. She hasreceived an overwhelmingly positiveresponse of technologists who are inter-ested in running for the SMRT Policy Board.Heidi and her committee are also preparinga list of nominees for the Crues and KresselAward for outstanding contributions to theeducation of MR technologists.

Cindy Comeau, from New York, NewYork, is the Chair of our Regionals Commit-tee. The SMRT goal is to host at least sixRegional Seminars each year. For this fiscalyear, the SMRT has held four RegionalSeminars. Past-President Heidi Berns heldthe first Regional Seminar in Iowa City,Iowa. The SMRT then presented a RegionalSeminar in Utica, New York, with anexcellent program and great attendance.Central New York was thrilled to have aRegional here and we look forward tovisiting again soon. In September the SMRThosted two Regional Seminars. The SMRTAtlanta Local Chapter hosted a RegionalSeminar in conjunction with the SMRT. TheAtlanta Chapter seminars always have agreat turnout of attendees. We also werevery excited to host our first CanadianRegional Seminar, in Montreal, Quebec,Canada. For the fiscal year 2002-2003 SMRTheld a very successful Regional Seminar inPittsburgh, Pennsylvania. Hosting aRegional is a very demanding but rewardingexperience. Cindy assists the local orga-nizer throughout the process of presentingthe Regional Seminar. In exchange, thelocal organizer receives a one-year waivedSMRT membership for their efforts.

Bobbie Burrow, from Atlanta, Georgia,is the Local Chapters Committee Chair.Bobbie indicates that there are currentlyeight SMRT Local Chapters: Atlanta,Georgia; Iowa City, Iowa; Springfield,Illinois; Kansas City, Missouri; Wichita,Kansas; Central Pennsylvania; Providence,Rhode Island; and Australia/New Zealand.Local chapters are an excellent way fortechnologists to be introduced to theSMRT in their local area. Bobbie has futureplans to expand the number of SMRT LocalChapters.

Scott Kurdilla, from Pittsburgh,Pennsylvania, heads our By-Laws Committee.Scott is serving his second year on the PolicyBoard and has gathered his committee toreview and update, if needed, the SMRT by-laws.

Raymond Cruz, from the state ofWashington, is returning for his second yearas Membership Committee Chair. Rayreports that the SMRT currently has 1,181members. Ray and his committee havedeveloped a member questionnaire, whichhas been mailed to those who have canceledtheir membership in the past year. The non-renewal rate has dropped to 5% this year.For US $75 per year, the SMRT has manybenefits to offer, including reducedregistration fees for all ISMRM/SMRTmeetings, workshops, and seminars; reducedsubscription fees to ISMRM journals, JMRIand MRM; quarterly SMRT Signals newsletter,and the ever-popular quarterly accreditedSMRT Educational Seminars Home Studies.

Kelly Baron, from Indiana, is the Chairof the Publications Committee and hasworked extremely hard in developing ourhome studies program. Julie Strandt-Peay,from Wisconsin, is the Signals newslettereditor. Kelly and Julie deserve a round ofapplause for their diligent work in thesetwo extremely busy areas of the SMRT.Signals made its debut on the SMRT websitewith the latest issue.

For those ISMRM members who are notfamiliar with the SMRT or its activities, Ifeel it is important for you to hear what theSMRT is all about and what it has to offerMR technologists worldwide. If you haveany questions or comments, please feel freeto contact me at [email protected].

In the next issue of MR Pulse I willhave more details about the upcoming SMRTAnnual Meeting in Toronto, as well asprogram information on the SMRT Forum tobe held Monday at the ISMRM ScientificMeeting. I will also announce the electionresults for the SMRT Policy Board and theCrues/Kressel Award.

— John A. Koveleski, SMRT President

ISMRM Section for MR TechnologistsSMRT Update


T he ISMRM Workshop “Diffusion MRI– Biophysical Issues: What Do We Really Measure?” washeld 10-12 March 2002 at the Frenchsite of the Palais du Grand Large lyingat the foot of the ramparts of the Cityof the Corsairs, Saint-Malo, facing theopen seas, a perfect venue for a“Diffusion Brainstorming Workshop bythe Sea.” This first internationalworkshop of the ISMRM Diffusion/Perfusion Study Group brought together135 attendees including 20 invitedspeakers and moderators.

For the last 15 years, diffusionMRI has enjoyed a tremendous growth,from basic science to major clinicalapplications, such as brain ischemia.Diffusion MRI is now a popular topic inmajor meetings, especially the annualISMRM meeting. Still, there remainmany questions about what we reallymeasure in biological tissues withdiffusion MRI. Tissues are complex,organized structures where the diffusionprocess largely differs from what isobserved in free, infinite, homogeneousmedia. There is a growing body ofknowledge in the literature, sometimescontroversial, about diffusion measure-ment in biological tissues (not onlyfrom MRI), and time had come to bringtogether experts in the field to sharetheir views on what they believe isreally measured with diffusion MRI.

Report on the ISMRM Workshop on Diffusion MRI(Biophysical Issues: What Do We Really Measure?)

This timely workshop was organizedas an open-minded, brainstormingmeeting between physicists, biologistsand clinicians with the hope to addresscontroversies and reach consensus onnew directions to be pursued. Thetopics covered included:

� Tools to assess diffusion in tissues:diffusion MRI, MRS, Q-space, nonMR measurements,

� Diffusion in multiple compartmentsand exchange effects,

� Relationship between diffusionmeasurements and tissue geometry:anisotropy, restriction, hindrance,cell volume effects,

� Using diffusion concepts to under-stand the normal and diseased brain(connectivity studies, clinicalapplications).

Drs. Le Bihan from CEA, Orsay,Van Zijl from Johns Hopkins, Baltimoreand Basser from NIH, Bethesda,Workshop Chairs, organized theprogram around six sessions. Eachsession consisted of 20-minute talksgiven either by invited speakers orparticipants whose abstracts had beenselected, and was followed by an amplediscussion period. In addition, two

key-note lectures (1 hour) weredelivered by well-known speakers.There were also three poster sessionsto accommodate proffered papers andstimulate discussion. To this purpose,posters were installed in the coffeebreak area. Lunches and dinners werearranged on-site to allow continued,informal discussion.

See Diffusion MRI page 20Workshop audience and participants enjoyed discussions ranging fromQ-space to connectivity.

Keynote speaker, Eva Syková, provides an enlightening presentation on“Extracellular Space Diffusion Parameters in CNS.”


Social events were also offereddaily to provide additional opportuni-ties for participants to interact in apleasant, relaxing atmosphere. Awelcome cocktail on the eveningpreceding the workshop allowedparticipants to check in with theirposters, as well as to check out localculinary delights. On Sunday night,champagne was offered by the CityMayor in an old tower of the City Hall,a beautiful castle. Champagne contin-ued to flow the next evening at agathering in a renovated mansion inthe Saint-Malo area. Guests were givena chance to “exercise” before enjoyinga fine gourmet dinner thanks to a localgroup of musicians who performed forone hour. Live Celtic music was very

entertaining, and guests were invitedto join an exciting lesson of populardances from Brittany. The last day aspecial break gave the participants achance to taste local oysters, whichhad been freshly collected in the earlymorning hours, traditionally servedwith Muscadet wine and Brittany saltybutter. Finally, the participants stayingover the next day were offered a trip toMont-Saint-Michel (“the 8th Wonder ofthe World”).

After a short introduction fromDr. Le Bihan, the workshop started onSunday morning with a series of talkson the “physics background” chaired byDrs. Basser and Cohen. Dr. Springerintroduced a concept of the “shutterspeed” to explain how it was possibleto play with the diffusion contrast andits tissue relationship through sequenceparameters. Several speakers discussedq-space measurements, showing theirgreat potential for the characterizationof tissue architecture and anisotropy.They also pointed out some difficultiesin the interpretation of q-space data,especially when displacement distribu-tions are not Gaussian and gradientpulses are not short enough comparedto the diffusion time.

The afternoon session, chairedby Drs. Mulkern and Stanisz, toucheda very controversial issue: diffusion inmultiple compartments and exchangeeffects. Although most speakersacknowledged that at least two diffu-sion pools, slow and fast diffusing,contributed to the diffusion decaycurves, the physical origin and thecompartments corresponding to thosepools remain a mystery. Earlier sugges-tions to ascribe these pools to theintra- and extracellular spaces werequestioned. No agreement has beenreached on the actual diffusion coeffi-cients of the extra- and intracellularcompartments. Heterogeneity andexchange effects probably play animportant role in the observed diffusionpatterns. The effect of intracellularflow (cytosolic streaming) on themeasured ADCs was also discussed.

Diffusion MRI

from page 19

See Diffusion MRI page 21Participants were treated to sumptuous meals inSaint-Malo, including a luncheon pictured at leftand an oyster break shown above.

At the Welcoming Ceremony the Saint-MaloMayor’s representative, Mme. Taillander,addresses Denis LeBihan (r) and the ISMRMWorkshop participants.

Stefan C.A. Steens andMark van Buchem atMalouinière de la Ville Gilles.

Student participants at the Monday nightgala dinner.

Michael E. Moseley and Peter Van Zijl withMarcel Pouchelet (center).

Poster sessions provided an opportunity for further scientificdiscussions.


Clearly there is no clear picture of whatis going on, and the only agreementwas that a “unified model” had still tobe found to explain tissue waterdiffusion.

On Monday morning Drs. Sotakand Leibfritz chaired and lectured tointroduce the field of tissue geometryand its relationship with water diffu-sion. The speakers showed experimen-tally and theoretically how changes incell volume (especially swelling) couldmodulate the ADC. Here also severalmechanisms and theories were pro-posed dealing either with intracellularor extracellular water. It was agreedthat several mechanisms likely contrib-ute to explain the ADC decrease thathas been observed in acute brainischemia, some brain disorders andnormal cortical activation. An out-standing lecture by Dr. Syková, key-note speaker, provided a stimulating“outside” view to the problem. Dr.Syková, who has years of experience indiffusion measurements of ions intissue preparations, clearly showedthat diffusion MRI data obtainedin vivo were in close agreement withher own measurements. She alsopointed out the existence of dynamicchanges in neural tissue structure,which could perhaps be observed withdiffusion MRI.

In the afternoon the issue ofdiffusion anisotropy was brought up.Drs. Van Zijl and Neil moderated thesession. The origin of water diffusionanisotropy in white matter was deeplydiscussed, while the evidence for

diffusion anisotropy in the brain cortexwas shown, especially at high resolu-tion and in the developing brain. Thesession was followed by a key-noteaddress by Dr. Pouchelet, who intro-duced his movie, “The Neuron Times.”After a short presentation on thetechnical tricks used to make themovie, all participants were astonishedby what they saw: Neurons and associ-ated cells of a tissue preparation arefilmed continuously for several daysusing a special microscope linked to acamera. Images are then mounted withan 100-fold or 1000-fold accelerationfactor, enabling us to witness part ofthe life of the neurons and observe howneurons form synapses or die.

The morning of the last day wasdedicated to fiber tracking, a popularand fast-growing application of diffu-sion tensor MRI. Drs. Wedeen andAlexander managed the session. Newalgorithms to increase the accuracy ofthe tracking, especially in regionswhere several bundles may cross, werepresented. The problem of the valida-tion of the results was also raised, andthe potential of manganese-enhancedT1-weighted MRI was clearly outlined inanimal models. Finally, the potential ofcombining DTI and fMRI was demon-strated. The use of MRI microscopycombined with DTI was demonstrated tohave potential for new types of3D “stains” of the brain. The afternoonsession, chaired by Drs. Moseley andConturo, addressed clinical issues.The idea was to suggest how diffusionMRI could help in understanding brain

Diffusion MRI

from page 20

disorders, for instance in terms oftissue structure changes in the cortexor white matter fiber anomalies.Examples were show in brain and spinalcord.

The success of the workshop,both scientifically and socially, wassignified by the many participants whoindicated a desire to meet again in thenear future to review research progressin the field.

ACKNOWLEDGEMENTS

The workshop organizers aregrateful to the workshop participantsfor their very active contribution tothe talks, poster and discussionsession, as well as to the invitedspeakers and session moderators fortheir dedication: C. Beaulieu,S. Blackband, Y. Cohen, J. Pfeuffer,C. M. Ellis, G. Stanisz, T. Klingberg,L.L. Latour, D. Leibfritz, T.H. Mareci,M. Moseley, J.J. Neil, C.H. Sotak,C.S. Springer, G.J. Stanisz, V. Wedeen,and the key-note speakers E. Syková,and M. Pouchelet (P.T. Callaghan wasnot able to attend).

Many thanks to the workshopsponsors: Siemens Medical Solutions,Bruker Biospin MRI, Inc., GE MedicalSystems, the French Atomic EnergyCommission, Life Science Division(CEA/DSV), the Centre national de laRecherche Scientifique (CNRS), theNeurofunctional Imaging FederativeResearch Institute (IFR49, Orsay). Theworkshop would not have been a successwithout their generous support.

The organizers would also like tocongratulate Mrs. Sophie Pellé and thestaff of the Palais du Grand Large atSaint-Malo for their wonderful supportand dedication, as well as the team ofthe Saint-Malo Mayor for their hospi-tality. Roberta Kravitz and BobGoldstein from the ISMRM officedeserve a magna cum laude for makingthe preparation and the organizationof the workshop so smooth andflawless.

– Denis Le Bihan, Workshop Chair and OrganizerPeter J. Basser and Peter C.M. van Zijl, Co-Chairs

Standing up for a discussion session (from l to r): Lawrence Latour, D. Jones, Nicolàs Lori,Robert Welsh, Van Wedeen, and Charlie Springer.


ISMRM Workshop Announcement

This workshop is the latest in a series designed to keep ISMRMmembers abreast of developments in the field of MR Safety. Theintroduction of high field human imaging systems (3-8 T), thedevelopment of rapidly switched gradient coils, the evolution ofradio frequency coils, the use of interventional MR, the proliferationof invasive devices in the MR environment, the increased use ofcontrast agents, the development of new MR safety standards, andthe need to harmonize international standards should make thissafety workshop timely. The workshop will be held in Europe inan effort to expand participation in the discussion of scientific andregulatory safety issues. The Strahlenshutzkomission, one of themajor regulatory organizations, has endorsed the workshop.

SESSION TOPICS

Session 1: B0 SafetySession 2: Gradient-Induced Stimulation SafetySession 3: Acoustic Noise SafetySession 4: RF SafetySession 5: Other Safety Issues

(including invasive devices) - ISession 6: Other Safety Issues

(including contrast agents & interventional MR) - IISession 7: Harmonization of World Wide Standards

(including panel discussion)Session 8: MR Clinical Safety

(including pediatric safety & safe practicesrecommendations)

EDUCATIONAL OBJECTIVESUpon completion of this workshop, participants should be able to:� Recognize MR safety concerns involving static magnetic fields,

time-varying gradients, and radio-frequency fields;� Recommend methods to minimize patient heating from surface

coils and other conductors;� Implement procedures to minimize patient and operator safety

concerns;� Compare various national and international safety standards and

limits;� Identify potential safety flaws in their current clinical scanning

procedures;� Evaluate safety aspects of new MR technologies currently under

development.

CREDIT HOURS AVAILABLE

The International Society for Magnetic Resonance in Medicinedesignates this continuing medical education activity for up to14.5 hours in Category 1 of the Physician’s Recognition Award ofthe American Medical Association. Each physician should claim onlythose hours of credit actually spent in the educational activity.

WORKSHOP ORGANIZERSScientific Program Committee� Gunnar Brix, Ph.D., Federal Office for Radiation Protection,

Oberschleissheim, Germany� Hans Engels, Ph.D., Philips Medical Systems, Best, Netherlands� Joel Felmlee, Ph.D., Mayo Clinic, Rochester, New York, USA� Georg Frese, Siemens Medical Solutions, Erlangen, Germany� Axel Haase, Ph.D., University of Würzburg, Würzburg, Germany� Dietbert Hahn, M.D., Kurnach, Germany� Jürgen Hennig, Ph.D., Universität Freiburg, Freiburg, Germany� David G. Norris, Ph.D., FC Donders Centre, Nijmegen, Nether-

lands� Daniel J. Schaefer, Ph.D., G.E. Medical Systems, Milwaukee,

Wisconsin, USA� Loren Zaremba, Ph.D., Food and Drug Administration, Rockville,

Maryland, USA

Local Organising Committee� Gunnar Brix, Ph.D., Federal Office for Radiation Protection,

Oberschleissheim, Germany� Michael Peller, Ph.D., University of Munich, Munich, Germany� Maximillian F. Reiser, M.D., University of Munich, Munich,

Germany

CALL FOR PAPERSProspective participants are invited to submit abstracts for poster or oralpresentation. Digital submission is encouraged in Word, WordPerfect,or simple text format; however, hard copy submission is allowed. Thedeadline for receipt of abstract submissions for both digital and paperabstracts is 15 December 2002.Abstracts should be no more than 1 page in length, including all images,tables, graphs, and references, and no smaller than 10pt font shouldbe used. An accompanying cover letter should indicate whether theabstract is to be considered for a talk or poster, and whether thepresentation could be a poster if it cannot be accommodated in anoral session (all unspecified abstracts will be considered for posters).The cover letter should include title of the abstract, name, affiliation,postal address, e-mail address, telephone number, and fax number foreach author. The cover letter should also include the name of theauthor who will be presenting the abstract, if accepted.The abstracts will be reviewed and selected by the workshop organizingcommittee. Acceptance will be based on scientific merit, relevance tothe field, clarity, soundness, and space availability. Early submission isencouraged!Notification of acceptance will be made by e-mail by 3 January 2003.All accepted abstracts are expected to be presented at the workshopand will be published in the workshop syllabus, which will be distributedto all workshop participants.Abstracts should be sent to:International Society for Magnetic Resonance in MedicineAttn: Current Issues in MR Safety Workshop2118 Milvia Street, Suite 201Berkeley, CA 94704 USAE-Mail: [email protected]

MAGNETIC RESONANCE IN MEDICINE

INTERNATIONAL SOCIETY FOR

ISMRM Workshop on

Current Issues in MR Safety23-24 February 2003ArabellaSheraton Grand, München, Germany

Endorsed by the German Radiological Protection CommissionStrahlenschutzkomission (SSK)

FOR FURTHER INFORMATION, PLEASE CONTACT ISMRMPhone: +1 510-841-1899 FAX: +1 510-841-2340 E-mail: [email protected] Website: http://www.ismrm.org


ISMRM Workshop Announcements



2002-2003 Meetings of Interest

20022002 DECEMBER

Meeting: RSNADate: 1-6 December 2002Where: McCormick Place, Chicago, Illinios, USAContact: Radiological Society of North America

820 Jorie Boulevard, Oak Brook, Il 60523Phone: +1 630 571 7852Fax: +1 630 571 7837Website: www.rsna.org

Endorsed by ISMRM:Meeting: First Eastern Mediterranean Congress and Second

National Congress of Magnetic Resonance ImagingDate: 12-14 December 2002Where: Izmir, TurkeyContact: E. Turgut Tali, M.D.Phone: +90-(312) 212 4040Fax: +90-(312) 212 4040 / +90-(312) 212 1940E-mail: [email protected]: www.mrder.org.tr

Meeting: 10th International MRI SymposiumMR 2003 MRI– Reinventing its Novelty

Date: 30 January - 1 February 2003Where: Garmisch-Partenkirchen, GermanyContact: Eurokongress

GmbH, Isartoplatz 3, D- 80331 München, GermanyPhone: ++49 0 89 210 98 60Fax: ++49 0 89 210 98 698E-mail: [email protected]: www.mr2003.org

Endorsed by ISMRM:Meeting: Biomedical Imaging Research Opportunities WorkshopDate: 31 January - 1 February 2003Where: Hyatt Regency, Bethesda, Maryland, USAContact: BIROW

One Physics Ellipse, College Park, Maryland, 20740 USAPhone: +1 301 209 3350Fax: +1 301-209-0862E-mail: [email protected]: www.birow.org

20032003 JANUARY

Meeting: Special Symposium MRI 2003:Clinical Update and Practical Applications

Date: 17-21 February 2003Where: Maui, Hawai‘i, USAContact: Danielle Klette, Harvard MED-CME

P.O. Box 825, Boston, Massachusetts, 02117-0825 USAPhone: +1 617 525 3310Fax: +1 617E-mail: [email protected]: www.radcme.harvard.edu

Workshop: ISMRM Workshop on Current Issues in MR SafetyDate: 23-24 February 2003Where: ArabellaSheraton Grand, München, GermanyContact: Registrar, ISMRM

2118 Milvia Street, Suite 201, Berkeley, CA 94704 USAPhone: +1 510 841 1899Fax: +1 510 841 2340E-mail: [email protected]: www.ismrm.org

FEBRUARY

FOR FURTHER INFORMATION,PLEASE CONTACT ISMRM

Phone: +1 510-841-1899FAX: +1 510-841-2340E-mail: [email protected]: http://www.ismrm.org

The purpose of the workshop is to explore the potential of MRspectroscopy and other modalities to provide new information onmetabolic and physiological processes that take place followingischemia, and recovery from ischemia and to increase ourunderstanding of mechanisms of cell death, the signaling pathwaysinvolved in ischemia, and metabolic strategies for protection againstand enhancement of recovery from ischemia. MRS allows one toexamine high-energy phosphate metabolism, tissue pH, and changesin different metabolites such as lactate, lipid metabolism, and Na+concentration. MRI can be used to study changes in tissueperfusion, diffusion, T1 and T2, distribution of contrast agents,and function. PET provides information on glucose metabolism andoxygen consumption, and SPECT on perfusion and thallium uptake.

This workshop should be of interest to spectroscopists and MRIexperts who may wish to learn about metabolism and physiology ofischemia, as well as to clinicians who may be interested in howdifferent metabolic imaging approaches may contribute to a betterunderstanding of ischemia.

ORGANIZING COMMITTEE� Jan A. den Hollander, Ph.D., Co-Chair, University of Alabama

at Birmingham, Birmingham, Alabama, USA� Peter G. Morris, M.A., Ph.D., Co-Chair, Nottingham University,

Nottingham, England, UK� E. Douglas Lewandowski, Ph.D., University of Illinois College

of Medicine, Chicago, Illinois, USA� James W. Prichard, M.D., Yale University School of Medicine,

New Haven, Connecticut, USA� Robert G. Weiss, M.D., Johns Hopkins Hospital, Baltimore,

Maryland, USA� Stephen R. Williams, D.Phil., University of Manchester,

Manchester, England, UK

Presented by the Dynamic NMR Study Group:

ISMRM Workshop onMetabolic Imaging of Ischemia23-25 March 2003Westin Grand Bohemian Hotel, Orlando, Florida, USA

ISMRM Workshop onCellular and Molecular Imagingin Diagnostics and TherapyJune 2003 Bordeaux, FrancePreliminary list of topics to be addressed:� New technologies in molecular and cellular imaging targeted to

specific biological pathways;� The role of the major imaging modalities in cellular and molecular

imaging;� The (potential) role of molecular imaging in advanced therapies,

notably gene therapy;� The (potential) role of cellular imaging in cell repair therapy,

notably via stem cells;� The basic principles of imaging of key biological processes such as

angiogenesis, apoptosis, inflammation.


2118 Milvia Street, Suite 201Berkeley, CA 94704 USA

International Society forMagnetic Resonance in Medicine2118 Milvia Street, Suite 201Berkeley, CA 94704, USAPhone: +1 510-841-1899FAX: +1 510-841-2340E-mail: [email protected]: http://www.ismrm.org

MR Pulse is published by theInternational Society forMagnetic Resonance in Medicine

Editor:James Earls, M.D.Associate Editor:Patrick Stroman, Ph.D.Executive Director:Jane E. TiemannPublications Manager:Sheryl Liebscher

Bill Negendank Award FundIn memory of William GeorgeNegendank, M.D., his colleagues inthe ISMRM MR of Cancer Study Grouphave established the Bill NegendankAward Fund to recognize outstand-ing young investigators in the field ofCancer MR (see MR Pulse, Vol. 3, No. 3,page 6). To make your tax-deduct-ible contribution, please send yourcheck made payable to the ISMRM orsubmit your Visa, MasterCard, Ameri-can Express, or Eurocard number,expiration date, and amount you wishto donate to the following address:

Bill Negendank Award FundInternational Society forMagnetic Resonance In Medicine2118 Milvia Street, Suite 201Berkeley, CA 94704, USA

20 NOVEMBER 2002Deadline for online receipt of Abstract submissions.

20 NOVEMBER 2002Deadline for receipt of Student Stipend Applications.

20 NOVEMBER 2002Deadline for receipt of Clinical Resident StipendProgram Applications.

20 NOVEMBER 2002Deadline for receipt of New Entrant Stipend ProgramApplications.

20 NOVEMBER 2002Deadline for receipt of E.K. Zavoisky StipendProgram Applications.

17 JANUARY 2003Deadline for receipt of Proffered Papers for theSMRT 12th Annual Meeting.

23-24 FEBRUARY 2003ISMRM Workshop on Current Issues in MR SafetyMünchen, Germany

28 MARCH 2003Deadline for Advance Registration for theISMRM Tenth Scientific Meeting & Exhibition.

10 - 16 MAY 2003

ELEVENTH SCIENTIFIC MEETINGAND EXHIBITIONToronto, Ontario, Canada

FRIDAY, 9 MAY 2003On-site Registration open from 14:00 - 20:00.SMRT Poster Tour & Reception 18:30 - 20:00.

SATURDAY, 10 MAY 2003Weekend Educational Programs begin.On-site Registration open from 06:30 - 18:00.SMRT 12th Annual Meeting begins 07:45.

SUNDAY, 11 MAY 2003Weekend Educational Programs continue.On-site Registration open from 07:30 - 18:00.SMRT 12th Annual Meeting continues.

MONDAY, 12 MAY 2003On-site Registration open from 06:30 - 18:30.Scientific Sessions begin at 07:45.Technical Exhibition open at 10:00.

TUESDAY – THURSDAY,13–15 MAY 2003On-site Registration open from 06:30 - 18.00.Morning Categorical Courses begin at 07:00.Scientific Sessions begin at 08:15.Technical Exhibition open at 09:30.

FRIDAY, 16 MAY 2003On-site Registration for Scientific Meeting from06:30 - 12:30.Morning Categorical Courses begin at 07:00.Scientific Sessions begin at 08:15.Scientific Meeting adjourns at 12:30.

ISMRM IMPORTANT DATESAND DEADLINES

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ISMRM Members: Let us hear from you so that you can hear from us!Make sure the ISMRM has your current contact information on file, including your email address,so that you don't miss out on important ISMRM news updates! To update your informationonline, visit the members only page of the ISMRM Website, http://www.ismrm.org, andclick on membership directory. Or, you may send changes to [email protected].

international society for magnetic …cds.ismrm.org/protected/mrpulse/mrpulsev9_3.pdfimaging, mr...

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