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Intimal Hyperplasia Post Carotid Endarterectomy George H. Meier, MD RVT FACS Professor and Chief, Vascular University of Cincinnati COM

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Page 1: Intimal Hyperplasia Post Carotid Endarterectomyjbcvascularsummit.com/wp-content/uploads/2018/04/2.6...2018/04/02 · CICO Hcrtzcr er Camelmo Bake; Shanik O'Donnell Picpgras Courbicr

Intimal Hyperplasia Post Carotid Endarterectomy

George H. Meier, MD RVT FACSProfessor and Chief, VascularUniversity of Cincinnati COM

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Disclosures

None

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Anyone who says they understand Intimal

Hyperplasia, is lying….

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Associations with IH• Embolectomy catheter induced,

associated with endothelial denudation

• Common after endarterectomy in any location

• Common after balloon angioplasty (~30%)

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Am J Surgery 1967

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mTOR Pathway

• Target for sirolimus

• Dysregulation associated with intimal hyperplasia

• Complicated!

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E2F

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E2F in LEB

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Conclusions• Carotid restenosis, although not

uncommon, rarely leads to stroke

• Treating asymptomatic restenosis is unwarranted

• We need to know more….

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