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Kidney International, Vol. 57, Suppl. 75 (2000), p. S-1 Introduction This supplement of Kidney International, which con- tes. Henk Bos et al consider the role of patient-related factors in the resistance to antiproteinuric interventions tains the Proceedings of the 8th Verona Seminar on both in diabetic and in nondiabetic renal diseases. The Nephrology, is dedicated to all those who believe that symptomatic treatment of chronic renal failure is mainly the progressive nature of renal diseases is the most fasci- based on dietary and pharmacological (antihypertensive, nating and mysterious topic in nephrology. The aim of lipid lowering) intervention. William F. Keane reviews this supplement is that of updating our knowledge on the role of lipids and treatment of hyperlipidemia in the complex mechanisms mediating progression of renal progressive renal diseases. William E. Mitch gives an disease and renal failure. overview of the role of dietary intervention on both the Vito M. Campese gives an overview of the neurogenic progression of renal disease and the nutritional impact factors involved in the hypertension of chronic renal in uremic patients whereas Carmelita Marcantoni et al failure. Saulo Klahr and Jeremiah Morrissey describe outline the advantages of a strict blood pressure control, the role of vasoactive compounds, growth factors and associated with an antiproteinuric effect, in slowing pro- cytokines and Agnes B. Fogo offers a critical appraisal gression of nondiabetic renal disease. Claudio Ponticelli of the roles of glomerular hypertension and abnormal summarizes the many aspects of chronic rejection and glomerular growth in progression of renal disease. The its treatment in renal transplant recipients. Finally, Eber- pivotal importance of tubular and interstitial damage hard Ritz et al offer a look into the future of the most in mediating progression is outlined by Leon G. Fine. promising methods for counteracting progression of re- Francesco Locatelli et al focus on the role of underlying nal disease. nephropathy, an often neglected but important factor, We gratefully acknowledge the educational support in affecting progressive deterioration of renal function. by Janssen Cilag Italia, which has made the publication Peter Hovind et al draw attention on the role of elevated of this supplement possible. levels of vascular endothelial growth factor in mediating Giuseppe Maschio and Lamberto Oldrizzi Guest Editors progressive renal damage in patients with type 1 diabe- Received for publication December 20, 1999 2000 by the International Society of Nephrology S-1

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Page 1: Introduction

Kidney International, Vol. 57, Suppl. 75 (2000), p. S-1

Introduction

This supplement of Kidney International, which con- tes. Henk Bos et al consider the role of patient-relatedfactors in the resistance to antiproteinuric interventionstains the Proceedings of the 8th Verona Seminar onboth in diabetic and in nondiabetic renal diseases. TheNephrology, is dedicated to all those who believe thatsymptomatic treatment of chronic renal failure is mainlythe progressive nature of renal diseases is the most fasci-based on dietary and pharmacological (antihypertensive,nating and mysterious topic in nephrology. The aim oflipid lowering) intervention. William F. Keane reviewsthis supplement is that of updating our knowledge onthe role of lipids and treatment of hyperlipidemia inthe complex mechanisms mediating progression of renalprogressive renal diseases. William E. Mitch gives andisease and renal failure.overview of the role of dietary intervention on both theVito M. Campese gives an overview of the neurogenicprogression of renal disease and the nutritional impactfactors involved in the hypertension of chronic renalin uremic patients whereas Carmelita Marcantoni et alfailure. Saulo Klahr and Jeremiah Morrissey describeoutline the advantages of a strict blood pressure control,the role of vasoactive compounds, growth factors andassociated with an antiproteinuric effect, in slowing pro-cytokines and Agnes B. Fogo offers a critical appraisalgression of nondiabetic renal disease. Claudio Ponticelliof the roles of glomerular hypertension and abnormalsummarizes the many aspects of chronic rejection and

glomerular growth in progression of renal disease. The its treatment in renal transplant recipients. Finally, Eber-pivotal importance of tubular and interstitial damage hard Ritz et al offer a look into the future of the mostin mediating progression is outlined by Leon G. Fine. promising methods for counteracting progression of re-Francesco Locatelli et al focus on the role of underlying nal disease.nephropathy, an often neglected but important factor, We gratefully acknowledge the educational supportin affecting progressive deterioration of renal function. by Janssen Cilag Italia, which has made the publicationPeter Hovind et al draw attention on the role of elevated of this supplement possible.levels of vascular endothelial growth factor in mediating Giuseppe Maschio and Lamberto Oldrizzi

Guest Editorsprogressive renal damage in patients with type 1 diabe-

Received for publication December 20, 1999

2000 by the International Society of Nephrology

S-1

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