introduction of micro-mixer
DESCRIPTION
Introduction of Micro-mixer. Lab on a chip. Mixing principles. Micro-scale. Micro-scale => laminar flow conditions => difficult to mix. Modes of Mixing. Split and recombine Serial segmentation Rotation Chaotic vortex Supply external energy Thermal - PowerPoint PPT PresentationTRANSCRIPT
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Introduction of Micro-mixer
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Lab on a chip
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Mixing principles
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Micro-scale
Micro-scale
=> laminar flow conditions
=> difficult to mix
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Modes of Mixing
Split and recombine Serial segmentation Rotation Chaotic vortex Supply external energy
Thermal
Acoustic
Electro-somotic
Mechanical
Passive
Active
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Mixing by diffusion
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Diffusive micro mixer - and gradient generator
Whitesides G. et al, Langmuir, Vol. 16, No. 22, 2000, 8311-8316
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Laminated flow cell scanner
Orwar O. et al Anal. Chem. 2002, 74, 6133-6138
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Laminated flow cell scanner- and decade gradient generator
Orwar O. Et al Anal. Chem. 2005, 77, 3897-3903
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Distributive micromixing chip
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Chaotic advection micro mixers- 3D rotation of the laminated flows
Nuguyen N-T., Fundamentals and applications of microfluidics
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Chaotic advection serpentine mixer -3D rotation of the laminated flows -
BEEBE D. et al. JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, VOL. 9, NO. 2, JUNE 2000
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Chaotic advection in serpentine mixer
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Chaotic advection mixing -grooved channel bottom-
G.M. Whitesides et al SCIENCE VOL 295 25 JANUARY 2002 647
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Chaotic advection mixing -patterned channel bottom-
Nuguyen N-T., Fundamentals and applications of microfluidics
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Chaotic advection mixing- periodic herring bone pattern -
G.M. Whitesides et al SCIENCE VOL 295 25 JANUARY 2002 647
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Chaotic advection mixing -periodic herring bone pattern-
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Dispersion properties of herringbone mixer
Straight
Herringbone
G.M. Whitesides et al Science Vol 295 25 Jan. 2002 647
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Serially segmented chaotic mixer
P. Tableing et al Physical Review E 72, 056312, 2005
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Multilamination mixing
Jensen K F. et al, Ind. Eng. Chem. Res., Vol. 44, No. 8, 2005
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Multilamination mixingand alkaline hydrolysis of methyl formate
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Multiphase mixing
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Semented flow mixing - gas/fluid -
Jensen KF. et al Langmuir, Vol. 21, No. 4, 2005
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Re-Pe diagram
Pe - inertia (advection) in relation to diffusionRe - inertia (advection) in relation to viscouseffects(laminar)
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TO MIX IN TENS OF MICROSECONDS Austin et al, PRL (2002)
On the order of30 nm in the extreme cases
Hydrodynamic Focusing
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Circular micromixing
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Circular micromixer
Quake, Scherer (2001)
Circular mixer
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In chaotic regimes, two close particles separate exponentiallyIn confined systems, this property is extremely favorable to mixing,
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From Ottino’s book : « Chaotic Advection »
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Thermal actuator
Micromixer
J. Evans, D. Liepmann, D., and A.P. Pisano, 1997, “Planar Laminar Mixer,” Proceeding of the IEEE 10th Annual Workshop of Micro Electro Mechanical Systems (MEMS ’97), Nagoya, Japan, Jan, pp.96-101.
Thermal mixer
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Main Flow
Time periodic transverse flow
V
-V
time
400 m
investigated by Y.K. Lee, C.M.Ho (1999), Mezic et al (1999)
Fluid A
FluidB
Advection mixer
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U
Perturbation is appliedLine is stretched
Perturbationis stoppedLine is folded
U
U
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200m
25m
1mm
actuation channel
Glass slide Working channel
Microvalve
Micro-valve
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QuickTime™ et un décompresseurH.263 sont requis pour visualiser
cette image.
Actuationpressure(bar)
Frequency (Hz)
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RESONANCESMAY BE USED TO SORTPARTICLES :
BY CHANGING THE FREQUENCY OF THE PERTURBATION, ONEOBTAINS A SYSTEM WHICH MIXES FLUIDS, FILTERS PARTICLES,OR SIMPLY TRANSPORTS MATERIALS
SIDE BY SIDE.
An efficient particle sorter, using resonance
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A.Dodge, P. Tabeling, A. Hountoundji, M.C.Jullien (2004)