introduction to human disease - uwa...unit outline week no. module 1 introduction 2 inflammation 3...
TRANSCRIPT
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Introduction to Human Disease
PATH2220
Dr Sonia Fernandez
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Contact Details
Unit website URL: http://www.lms.uwa.edu.au
Unit coordinator: Dr Sonia Fernandez
Email: [email protected]
Phone: 9224 0223
Location: 2nd floor MRF Building, near RPH
Consultation hours: By appointment
Unit deputy coordinator: Dr Ben Dessauvagie
Email: [email protected]
Location: Anatomical Pathology, PathWest, FSH
Consultation hours: By appointment
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Unit Overview
• Provides a broad understanding of human disease processes
• Divided into 1 or 2 week modules
– Pathological process “disease mechanism”
– Examples of human diseases
• Level 2 unit – will provide broad coverage of major disease processes with a greater depth of knowledge provided in Level 3 units
• A “showcase” of pathology aiming to:
– Give a broad understanding of human disease processes
– Illustrate pathological processes with examples of diseases resulting from these pathological processes
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Unit Outline
Week No. Module
1 Introduction
2 Inflammation
3 Immunity and disease
4 Lifestyle and disease
5 Blood vessels and disease
6 Blood and blood disorders
7 Neoplasia 1
8 Forensic Pathology & Mid Sem Test
9 Neoplasia 2
10 Environment and disease
11 Infection and disease
12 Genetics and disease
13 Research and course review
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What is Pathology?
• Pathology
– The scientific study of disease (patterns, causes, mechanisms and effects)
• Disease:
– A condition in which the normal function (homeostasis) of some part or organ of the body is disturbed
– A condition of the organism which limits its life in either its powers, enjoyment or duration (WHO)
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What is Pathology?
• Link between basic biological sciences and clinical practice
Anatomy Physiology BiochemistryGenetics
ClinicalPractice
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Week 1: Introduction
• Essential for one or more of diagnosis, prognostication, treatment
• Education necessary to understand:
– nature of disease mechanisms
– derangements of normal anatomy, physiology, and biochemistry
– how the above relate to manifestations seen in patient
• Scientific research
– Cellular and molecular basis of disease
– Foundation upon which modern medicine is based
• Introduction to ePractical resources and cell/tissue collection & processing
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Week 2: Inflammation
• Inflammatory process
• Cells
• Tissues
• Clinical examples
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Week 3: Immunology & disease
• Normal immunity
• Overactive vs underactive
• Allergy
• Autoimmunity
• Immunodeficiency
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Week 4: Lifestyle & disease
• Nutrition
• Diabetes
• Alcohol
• Iron metabolism
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Week 5: Blood vessels & disease
• The heart & blood vessels
• Bleeding & Clotting
• Heart attack
• Stroke
• “Economy class syndrome”
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Week 6: Blood & blood disorders
• Haematology
• Anaemia
• Leukocyte disorders
• Leukaemia
• Transfusion
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Weeks 7 & 9: Neoplasia (cancer)
• What causes cancer
• Types of cancer
• Cancer genetics
• How we diagnose cancer
• How cancer spreads
• Colon, Cervix, Lung, Skin
• Breast cancer
• Leukaemia
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Week 8: Forensic pathology
• What is forensic pathology?
• Natural disease
• Cause of unexplained or violent deaths
• Trauma
Note: The Mid-Semester Test is scheduled for this week in place of an e-learning prac
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Week 10: Environment & disease
• Environmental agents and disease
• Smoking
• Radiation
• Asbestos
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Week 11: Infection & disease
• Infection and disease
• How we diagnose infections
– Bacterial
– Viral
• Tuberculosis
• Malaria
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Week 12: Genetics & disease
• Principles
– Autosomal vs X-linked
– Dominant vs recessive
• Methods
• Management
• Haemophilia
• Thalassaemia
• Cystic fibrosis
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Week 13: Research & Course Review
• Translating pathology to practice
• Clinical pathology research
• All disciplines
• Biology, treatment, prognosis, monitoring
• Importance of pathology in understanding human disease
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Teaching programme: lectures
Day Time Venue
Monday 10:00 – 10:45(Mechanism)
FJ Clark Lecture Theatre,Queen Elizabeth II Medical Centre
Tuesday 10:00 – 10:45(Disease 1)
FJ Clark Lecture Theatre,Queen Elizabeth II Medical Centre
Tuesday 11:00 – 11:45(Disease 2)
FJ Clark Lecture Theatre,Queen Elizabeth II Medical Centre
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Teaching programme: ePracticals
Day Time Venue
Thursday 09:00 – 10:45 eLearning Suites Ground Floor, M BlockQueen Elizabeth II Medical Centre
Friday 09:00 – 10:45 eLearning SuitesGround Floor, M BlockQueen Elizabeth II Medical Centre
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eLearning Suites
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ePracticals
• Attend Thursday or Friday
• Interactive sessions using clinical cases to illustrate pathology of human disease
• Macroscopic, microscopic & radiological images
• Text, on-line resources
• Worksheets with questions
• Work in groups of 6
• Post-class quizzes: comprise 15% of unit mark
– Deadline: Monday 5pm each week
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PATH2220 Assessment
• PATH2220 unit assessment: % of Final Mark
– ePractical assessment 15%
– Written assignment 15%
– Mid-Semester test 20%
– Final examination (End of semester): 50%
• Extended matching questions 25%
• Written (short answer) questions 25%
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Written Assignment
• 1 written assignment
• Select an assignment topic from a list
• All details of requirements in Unit Guidebook
• Maximum 6 pages
• Submit via LMS in PDF format
• Deadline: by 5pm Monday 2nd October
• 15% of unit mark
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Mid Semester Test
• To see how you are going ….
• Date: Thursday 21st or Friday 22nd September
• Location: eLearning Suites
• 1 hour duration
• Format the same as final exam
– Extended Matching Questions (50%)
– Short answer questions (50%)
• 20% of unit mark
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End of Semester Exam
• 2 hour duration
• Format
– Extended Matching Questions (50%)
– Short answer questions (50%)
• 50% of unit mark
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Recommended Texts
• Your main source of information will be the lecture notes and epractical resources provided to you
• Complementary texts
– Pathology at a Glance – C. Finlayson & B. Newell, 1st Ed. 2009. Publisher: Wiley-Blackwell
– Immunology at a Glance – J.H.L Playfair and B .M. Chain, 10th Ed. Publisher: Wiley-Blackwell
– Haematology at a Glance – A. Mehta and V. Hoffbrand, 4th Ed. 2013. Publisher: Wiley-Blackwell
– Medical Genetics at a Glance – D.J. Pritchard and B.R. Korf, 3rd Ed. 2013. Publisher: Wiley-Blackwell
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Contact Information
• Direct your enquiries to the LMS discussion board
– I am subscribed so I will see them
– Your questions may benefit others
• Confidential enquiries - email unit coordinator directly
– If detailed information is required a phone call or appointment may be appropriate
• Questions about unit content should be directed to the LMS discussion forum
• Please check the “Announcement” section before sending an email - your question may have already been addressed!