introduction to organic compounds- carbon copyright © 2009 pearson education, inc
TRANSCRIPT
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INTRODUCTION TO ORGANIC COMPOUNDS- CARBON
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3.1
Diverse molecules found in cells are composed of carbon bonded to other elements
– Carbon-based molecules are called organic compounds
– By sharing electrons, carbon can bond to four other atoms
– By doing so, it can branch in up to four directions
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Structuralformula
Ball-and-stickmodel
Space-fillingmodel
Methane
The four single bonds of carbon point to the cornersof a tetrahedron.
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3.1
Methane and other compounds composed of only carbon and hydrogen are called hydrocarbons
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A chain of carbon atoms is called a carbon skeleton
– Carbon skeletons can be branched or unbranched
– Therefore, different compounds with the same molecular formula can be produced
– These structures are called isomers
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3.1
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Carbon skeletons vary in length.
Branching. Skeletons may be unbranched or branched.
Butane Isobutane
PropaneEthane
Double bonds.
2-Butene
Skeletons may have double bonds,which can vary in location.
Cyclohexane
Length.
1-Butene
Benzene
Skeletons may be arranged in rings.Rings.
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Double bonds.
2-Butene
Skeletons may have double bonds,which can vary in location.
1-Butene
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Cyclohexane Benzene
Skeletons may be arranged in rings.Rings.
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3.2
An organic compound has unique properties that depend upon
– The size and shape of the molecule and
– The groups of atoms (functional groups) attached to it
A functional group affects a biological molecule’s function in a characteristic way
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3.2
Compounds containing functional groups are hydrophilic (water-loving)
– This means that they are soluble in water, which is a necessary prerequisite for their roles in water-based life
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Estradiol
Male lionTestosterone
Female lion
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3.3
The four classes of biological molecules contain very large molecules – macromolecules or polymers (made from identical building blocks strung together)
– The building blocks are called monomers
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A cell makes a large number of polymers from a small group of monomers
– Proteins are made from only 20 different amino acids, and DNA is built from just four kinds of nucleotides
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3.3
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3.3 Chemical Reactions and Enzymes
Monomers are linked together to form polymers through dehydration reactions, which remove water
Polymers are broken apart by hydrolysis, the addition of water
All biological reactions of this sort are mediated by enzymes, which speed up chemical reactions in cells
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Unlinkedmonomer
Short polymer
Longer polymer
Dehydrationreaction
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Hydrolysis
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CARBOHYDRATES
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3.4
Carbohydrates range from small sugar molecules (monomers) to large polysaccharides
– Sugar monomers are monosaccharides, such as glucose and fructose
– These can be hooked together to form the polysaccharides
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3.4
The carbon skeletons of monosaccharides vary in length
– Glucose and fructose are six carbons long
– Others have three to seven carbon atoms
Monosaccharides are the main fuels for cellular work
– Monosaccharides are also used as raw materials to manufacture other organic molecules
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Glucose(an aldose)
Fructose(a ketose)
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Structuralformula
Abbreviatedstructure
Simplifiedstructure
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3.5
Two monosaccharides (monomers) can bond to form a disaccharide in a dehydration reaction
– An example is a glucose monomer bonding to a fructose monomer to form sucrose, a common disaccharide
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Glucose Glucose
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Glucose Glucose
Maltose
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3.7
Polysaccharides are polymers of monosaccharides
– They can function in the cell as a storage molecule or as a structural compound
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3.7
Starch - found in plants
Glycogen - hydrolyzed by animals when glucose is needed
Cellulose is a polymer of glucose that forms plant cell walls
Chitin is a polysaccharide used by insects and crustaceans to build an exoskeleton
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3.7
Polysaccharides are hydrophilic (water-loving)
– Cotton fibers, such as those in bath towels, are water absorbent
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Starch granules inpotato tuber cells
Glycogengranulesin muscletissue
Cellulose fibrils ina plant cell wall
Cellulosemolecules
Glucosemonomer
GLYCOGEN
CELLULOSE
Hydrogen bonds
STARCH
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LIPIDS
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3.8
Lipids are water insoluble (hydrophobic, or water fearing) compounds that are important in energy storage
– They contain twice as much energy as a polysaccharide
Fats are lipids made from glycerol and fatty acids
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3.8
Fatty acids link to glycerol by a dehydration reaction
– A fat contains one glycerol linked to three fatty acids
– Fats are often called triglycerides because of their structure
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Fatty acid
Glycerol
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3.8
Some fatty acids contain double bonds
– These compounds are called unsaturated fats because they have fewer than the maximum number of hydrogens
– Fats with the maximum number of hydrogens are called saturated fats
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3.8
Phospholipids are structurally similar to fats and are an important component of all cells
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Water
Hydrophobictails
Hydrophilicheads
Water
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3.9
Steroids are lipids composed of fused ring structures
– Cholesterol is an example of a steroid that plays a significant role in the structure of the cell membrane
– In addition, cholesterol is the compound from which we synthesize sex hormones
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3.10
Anabolic steroids are synthetic variants of testosterone that can cause a buildup of muscle and bone mass
– They can be sold as prescription drugs and used to treat certain diseases
– They may also be abused with serious consequences, such as liver damage that can lead to cancer
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PROTEINS
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3.11
A protein is a polymer built from various combinations of 20 amino acid monomers
– Proteins have unique structures that are directly related to their functions
– Enzymes, proteins that serve as metabolic catalysts, regulate the chemical reactions within cells
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3.12
Amino acids, the building blocks of proteins, have an amino group and a carboxyl group
– Both of these are covalently bonded to a central carbon atom
– Also bonded to the central carbon is a hydrogen atom and some other chemical group symbolized by R
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Carboxylgroup
Aminogroup
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3.12
Amino acids are classified as hydrophobic or hydrophilic
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Leucine (Leu)
Hydrophobic
Serine (Ser)
Hydrophilic
Aspartic acid (Asp)
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3.12 Proteins are made from amino acids linked by peptide bonds
Amino acid monomers are linked together to form polymeric proteins
- accomplished by an enzyme-mediated dehydration reaction linking carboxyl and amino group in a bond called the peptide bond
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Carboxylgroup
Amino acid
Aminogroup
Amino acid
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Carboxylgroup
Amino acid
Aminogroup
Amino acid
Peptidebond
Dipeptide
Dehydrationreaction
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3.13
A polypeptide chain contains hundreds or thousands of amino acids linked by peptide bonds
– The amino acid sequence causes the polypeptide to assume a particular shape
– The shape of a protein determines its specific function
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Groove
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Groove
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3.13
If for some reason a protein’s shape is altered, it can no longer function
– Denaturation will cause polypeptide chains to unravel and lose their shape and, thus, their function
– Proteins can be denatured by changes in salt concentration and pH
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3.14
A protein can have four levels of structure
– Primary structure
– Secondary structure
– Tertiary structure
– Quaternary structure
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3.14
The primary structure of a protein is its unique amino acid sequence
– The correct amino acid sequence is determined by the cell’s genetic information
– The slightest change in this sequence affects the protein’s ability to function
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Collagen
Polypeptidechain
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Four Levels of Protein Structure
Amino acids
Primary structure
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Four Levels of Protein Structure
Amino acids
Primary structure
Alpha helix
Hydrogenbond
Secondary structure
Pleated sheet
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Four Levels of Protein Structure
Amino acids
Primary structure
Alpha helix
Hydrogenbond
Secondary structure
Pleated sheet
Polypeptide(single subunitof transthyretin)
Tertiary structure
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Four Levels of Protein Structure
Amino acids
Primary structure
Alpha helix
Hydrogenbond
Secondary structure
Pleated sheet
Polypeptide(single subunitof transthyretin)
Tertiary structure
Transthyretin, withfour identicalpolypeptide subunits
Quaternary structure
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Amino acids
Primary structure
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Amino acids
Alpha helix
Hydrogenbond
Secondary structure
Pleated sheet
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Polypeptide(single subunitof transthyretin)
Tertiary structure
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Transthyretin, withfour identicalpolypeptide subunits
Quaternary structure
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NUCLEIC ACIDS
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3.16
DNA (deoxyribonucleic acid) and RNA (ribonucleic acid) are composed of monomers called nucleotides
– Nucleotides have three parts
– A five-carbon sugar called ribose in RNA and deoxyribose in DNA
– A phosphate group
– A nitrogenous base
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Phosphategroup
Nitrogenousbase
(adenine)
Sugar
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Basepair