introduction to rheumatology - university of pretoria · introduction to rheumatology dr. christa...
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![Page 1: Introduction to Rheumatology - University of Pretoria · Introduction to Rheumatology Dr. Christa Visser MBChB MMed (Med Phys) Diploma in Orthopaedic Medicine](https://reader030.vdocument.in/reader030/viewer/2022040219/5e1126a5fbdbf479a96bed4f/html5/thumbnails/1.jpg)
Introduction to Rheumatology
Dr. Christa VisserMBChB MMed (Med Phys)
Diploma in Orthopaedic Medicine
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Rheumatology
• Musculoskeletal Pain (excl. acute trauma) – Arthritis – Soft tissue rheumatism
• Connective Tissue Diseases eg SLE
• Bone disease eg osteoporosis
UPuser:UPuser:
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Rheumatological Assessment
• LOCAL: Which structure/s are involved?
• SYSTEMIC: Is there any systemic involvement?
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Evaluation of Origin of Pain
NEUROPATHIC PAIN (neural damage)Trauma, toxic, pressure,
infection, ischaemia,nutritional, infiltration
NOCICEPTIVE PAIN (tissue damage)Acute or chronic traumaInflammation or infection
Neoplasm etc
PAIN
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Evaluation of Origin of Pain
NEUROPATHIC PAIN (nerve, root, CNS damage)Often sensory disturbances
Sometimes weakness/wastingSometimes abnormal reflexes and tone
NOCICEPTIVE PAIN (tissue damage)
PAIN
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Evaluation of Origin of Pain
NEUROPATHIC PAIN (nerve, root, CNS)Often sensory disturbances
Sometimes weakness/wastingSometimes abnormal reflexes and tone
VISCERAL (Organs) SOMATIC (Musculoskeletal)
NOCICEPTIVE PAIN (tissue damage)Acute or chronic traumaInflammation or infection
Neoplasm etc
PAIN
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Evaluation of Origin of Pain
NEUROPATHIC PAIN (nerve, root, CNS)Often sensory disturbances
Sometimes weakness/wastingSometimes abnormal reflexes and tone
VISCERAL (Organs)Referred from organ eg pancreas, heart, aorta
Palpation/movement of painful area does not increase the pain
SOMATIC
NOCICEPTIVE PAIN (tissue damage)Acute or chronic traumaInflammation or infection
Neoplasm etc
PAIN
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Evaluation of Origin of Pain
NEUROPATHIC PAIN (nerve, root, CNS)Often sensory disturbances
Sometimes weakness/wastingSometimes abnormal reflexes and tone
VISCERAL (Organs)Referred from organ eg pancreas, heart, aorta
Palpation & movement of painful area do not increase the pain
SOMATIC (Musculoskeletal)Postures and movements which stress the affected
tissue increase the pain
NOCICEPTIVE PAIN (tissue damage)Acute or chronic traumaInflammation or infection
Neoplasm etc
PAIN
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enthesitis
ligament injury
tenosynovitis
Capsulitis or capsule injury
COMMON SITES OF MUSCULOSKELETAL PAIN
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No pain PAIN!!!!
TESTING INERT STRUCTURES WITH PASSIVE MOVEMENTS
(LIGAMENT, CAPSULE, RELAXED MUSCLE & TENDON)
Inflamed/injured tissuerelaxed
Inflamed/injured tissuestretched
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TESTING MUSCULOTENDINOUS UNIT WITH PASSIVE AND RESISTED MOVEMENTS
PASSIVE STRETCH
RESISTEDMOVEMENT
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Evaluation of Origin of Pain
NEUROPATHIC PAIN (nerve, root, cord etc)Often sensory disturbances
Sometimes weakness/wastingSometimes abnormal reflexes and tone
VISCERAL (organs)Referred from organ eg pancreas, heart, aorta
Palpation/movement of painful area does not increase the pain
LOCAL PAIN (distal and superficial structures)Movements stressing the structure causes pain
Originate in joint or peri-articular soft tissueOrigin identified by selective tension tests
REFERRED FROM SOMATIC STRUCTUREEsp proximal structures: eg hip refers to knee
Movement of 'painful' area does not reproduce painbut movement of the 'originating' area does
SOMATICPostures and movements which stress the affected
tissue increase the pain
NOCICEPTIVE PAIN (tissue damage)Acute or chronic traumaInflammation or infection
Neoplasm etc
PAIN
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Evaluation of Origin of Pain
NEUROPATHIC PAIN (nerve, root, cord etc)Often sensory disturbances
Sometimes weakness/wastingSometimes abnormal reflexes and tone
VISCERAL (organs)Referred from organ eg pancreas, heart, aorta
Palpation/movement of painful area does not increase the pain
LOCAL PAIN (distal and superficial structures)Movements stressing the structure causes pain
Originate in joint or peri-articular soft tissueOrigin identified by selective tension tests
REFERRED FROM SOMATIC STRUCTUREEsp proximal structures: eg hip refers to knee
Movement of 'painful' area does not reproduce painbut movement of the 'originating' area does
SOMATICPostures and movements which stress the affected
tissue increase the pain
NOCICEPTIVE PAIN (tissue damage)Acute or chronic traumaInflammation or infection
Neoplasm etc
PAIN
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Rheumatological Assessment
• History/Symptoms
• Examination– ‘Look’– ‘Feel’– ‘Move’
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Symptoms in Rheumatology
• Pain• Swelling• Redness• Heat• Stiffness• Instability• Deformity• Functional problems• Systemic symptoms
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‘Look’(‘Be Careful With Spaghetti’)
• Bony/Alignment: eg valgus/varus/ flexion deformity
• Colour/Skin: eg red, white, blue, rashes, pigmentation, ulcers, scleroderma etc
• Wasting
• Soft Tissue: eg joint swelling, nodules
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‘Feel’
• Temperature
• Swelling: – Synovitis: boggy swelling along joint line– Effusion: fluid fluctuation– Bone: hard eg Heberden nodules
• Tenderness
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‘Move’
• Active
• Passive:– Stress inert structures (eg ligaments, relaxed
muscle)– Capsular pattern: pattern of reduction in
movements specific for every joint if the joint itself affected
• Resisted: – Stress individual muscles and their tendons
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Summary
• Exclude neuropathic pain• Exclude referred pain from viscera• Identify which musculoskeletal
structure is causing pain– Local vs referred– Joint vs soft tissue
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Descriptive Terms
• Synovitis• Bursitis• Arthralgia• Arthritis• Monoarthritis• Oligo/pauci-arthritis• Polyarthritis• Juvenile arthritis
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Descriptive Terms
• Tendonitis/Tendinosis• Tenosynovitis• Enthesitis
• Myalgia• Myositis• Malaise
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Descriptive Terms
• Chondritis• Chondromalacia
• Osteitis/osteomyelitis• Osteopaenia• Osteoporosis• Osteomalacia
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Descriptive Terms
• Early morning stiffness• ‘Gelling’• Ankylosis (surgical=arthrodesis)
• Pseudo-instability• Hypermobility (Beighton scale)
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Descriptive Terms
• Varus deformities (cubiti, genu, calcaneo, hallux)
• Valgus deformities (cubiti, genu, calcaneo, hallux)
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Descriptive Terms
• Small vs large joint involvement
• Symmetrical vs asymmetrical disease
• Axial disease vs peripheral joint involvement
• Juvenile arthritis: onset < 16 years
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PrimarySecondary
Osteoarthritis
GoutPseudogout/
Chondrocalcinosis
Crystal arthritis Rheumatoid arthritis
Ankylosing spondylitisPsoriatic arthritis
Enteropathic arthritisReactive arthritis
Spondylarthropathies
SLESystemic sclerosis
Poly-/DermatomyositisMCTD
ConnectiveTissue
Diseases
Giant cell arteritisTakayasu
PANWegeners etc
Vasculitis
ARTHRITIS
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Osteoarthritis
• Cartilage softening & degeneration• Normal blood tests• Types:
– Primary: knees, hips, 1st CMC, DIP, PIP, spine
– Secondary: preceding joint abnormality eg #, dysplasia
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Osteoarthritis of the DIP joints with Heberden’s nodes.
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Extensive OA with complete loss of the joint space in a concentric pattern and subchondralbone destruction.
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PrimarySecondary
Osteoarthritis
GoutPseudogout/
Chondrocalcinosis
Crystal arthritis Rheumatoid arthritis
Ankylosing spondylitisPsoriatic arthritis
Enteropathic arthritisReactive arthritis
Spondylarthropathies
SLESystemic sclerosis
Poly-/DermatomyositisMCTD
ConnectiveTissue
Diseases
Giant cell arteritisTakayasu
PANWegeners etc
Vasculitis
ARTHRITIS
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Crystal deposition diseases: Gout
• Monosodium urate crystal deposition (tophi) in bone, joints, soft tissue
• Bone and joint destruction (can be very severe)
• Raised serum urate• Monosodium urate crystals in
synovial fluid
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An ulcerating tophusof a distal inter-phalangeal joint with associated redness of the overlying skin
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Polarized light microscopy: extracellularbirefringent needle-shaped uratecrystals.
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Gout: A large tophusis replacing much of the fifth left metatarsal.
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Crystal deposition diseases: Pseudogout/Chondrocalcinosis/
CPPD deposition disease
• Calciumpyrophosphate dihydrate crystals in joints and soft tissue
• No blood tests• X-ray: cartilage and soft tissue
calcification• Synovial fluid: CPPD crystals
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‘Bloody old shoulders’. This elderly patient has visible swellings of both shoulders. Aspiration revealed a large amount of blood-stained fluid which contained numerous particles of basic calcium phosphates.
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Synovial fluid CPPD crystals.
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Knee radiograph showingchondrocalcinosis of both fibrocartilage(meniscus) and hyaline cartilage.
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PrimarySecondary
Osteoarthritis
GoutPseudogout/
Chondrocalcinosis
Crystal arthritis Rheumatoid arthritis
Ankylosing spondylitisPsoriatic arthritis
Enteropathic arthritisReactive arthritis
Spondylarthropathies
SLESystemic sclerosis
Poly-/DermatomyositisMCTD
ConnectiveTissue
Diseases
Giant cell arteritisTakayasu
PANWegeners etc
Vasculitis
ARTHRITIS
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Rheumatoid arthritis
• Synovial inflammation leading to joint destruction
• Joint >>>> Systemic• Rheumatoid factor often present• Musculoskeletal
– Symmetrical arthritis– Little spinal involvement except
cervical instability
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ACR criteria (4/7)
• Early morning stiffness > 1 hour• Symmetric arthritis• > 3 Joint arthritis• Arthritis of one or more of: wrists, MCP’s, PIP’s• Rheumatoid nodules• Rheumatoid factor present• RA X-ray changes: periarticular osteopaenia OR
erosions
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PrimarySecondary
Osteoarthritis
GoutPseudogout/
Chondrocalcinosis
Crystal arthritis Rheumatoid arthritis
Ankylosing spondylitisPsoriatic arthritis
Enteropathic arthritisReactive arthritis
Spondylarthropathies
SLESystemic sclerosis
Poly-/DermatomyositisMCTD
ConnectiveTissue
Diseases
Giant cell arteritisTakayasu
PANWegeners etc
Vasculitis
ARTHRITIS
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Spondylarthropathies
• Synovial and enthesial inflammation leading to joint destruction/ spinal ankylosis
• Joint>>>> Systemic• Musculoskeletal
– Asymmetric arthritis– Sacro-iliac and spinal inflammation and
ankylosis– Enthesitis
• HLA B 27 often present
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Spondylarthropathies
• Types:– Ankylosing spondylitis – Psoriatic arthritis– Enteropathic arthritis – Reactive arthritis (Reiters
syndrome)
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*20cm*15 cm
…... ……
*MODIFIED SCHOBER TEST
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Distal interphalangealjoint involvement in psoriatic arthritis.
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Dactylitis of the index finger.
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Ankylosing spondylitis: A radiograph of a macerated specimen demonstrate a typicalsyndesmophyte bridging the intervertebral disc space. It is thin, vertically oriented and orginatesfrom the margins of vertebral bodies.
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Enthesopathy at the sites of attachment of the Achilles tendon and plantar aponeurosis
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Psoriatic arthritis: DIP joint pencil-in-cup appearance.
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PrimarySecondary
Osteoarthritis
GoutPseudogout/
Chondrocalcinosis
Crystal arthritis Rheumatoid arthritis
Ankylosing spondylitisPsoriatic arthritis
Enteropathic arthritisReactive arthritis
Spondylarthropathies
SLESystemic sclerosis
Poly-/DermatomyositisMCTD
ConnectiveTissue
Diseases
Giant cell arteritisTakayasu
PANWegeners etc
Vasculitis
ARTHRITIS
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Connective Tissue Diseases
• Synovial inflammation stretches capsule and leads to instability but no erosions
• Systemic >>>> Joint• Musculoskeletal
– Symmetric arthritis
• Anti-nuclear factor often present
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Connective Tissue Diseases
• Types– Systemic lupus erythematosis– Systemic sclerosis (Scleroderma)– Polymyositis/Dermatomyositis– Mixed Connective Tissue disease– Overlap syndromes
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SLE (4/11 criteria)• Discoid rash• Malar rash
• Serositis: pleurisy, pericarditis, effusions• Oral ulcers• Arthritis: symmetric, nonerosive• Photosensitivity
• Blood: ↓ WBC ↓lympho’s ↓plt Haem anaemia• Renal: haematuria, proteinuria, casts, failure• ANF• Immunologic: + anti Sm• Neurologic: new seizures, psychosis
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Swan neck deformities in a patient with SLE.
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Malar rash in a patient with SLE.
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Systemic sclerosis• Raynaud’s phenomenon• Skin thickening (scleroderma)• Arthritis and tenosynovitis• Fibrosis of organs, eg oesophagus, lungs• Scleroderma renal crisis (HT+failure)• ANF, Anti-Sm, Anti-centromere often +
A limited form of systemic sclerosis is called CREST syndrome = calcinosis, Raynaud’s, esophageal dysmotility, sclerodactily (scleroderma of distal extremities), telangiectasia
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Limited mouth opening and punctate telangiectasias in longstanding limitedscleroderma.
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Poly-& Dermatomyositis
• Proximal muscle weakness• Skin rash over hand and face with
dermatomyositis• Arthralgia/arthritis• Raised CK• Abnormal EMG• Abnormal muscle histology• ANF, Anti-Jo 1 often +
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Heliotrope rash ofdermatomyositis. The erythematous or violaceous rash over the eyelids of this patient withdermatomyositis and breast cancer is a characteristiccutaneous feature.
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Blood tests NXR
Cartilage
Primary: DIPPIP, 1CMC, spine,hip, knee,1 MTP
Secondary:
OA
Urate levelSynovial fluid
XR
CartilageSynoviumSoft tissue
Bone
GoutPseudogout
Crystal
RFXR
SynoviumJoints + C-spine
Joints >> Systemic
RA
HLA B27XR
SynoviumEntheses
Axial + peripheraljoints >> Systemic
ASPsoriatic
EnteropathicReactive
SpA
ANFENA
Organ Fx tests
SynoviumSystemic >> Joints
SLEPSS
PM/DMMCTD
CTD
ANCAHistologyImaging
SynoviumSystemic >>Joints
PAN,Wegeners,Takayasu,GCA, etc
Vasculitis
Arthritis
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