introduction to text miningintroduction to text mining! >10 km patent literature grant proposals...
TRANSCRIPT
![Page 1: Introduction to text miningIntroduction to text mining! >10 km patent literature grant proposals too much to read computer as smart as a dog teach it specific tricks named entity](https://reader030.vdocument.in/reader030/viewer/2022040115/5e84fd3c4680b43735732b41/html5/thumbnails/1.jpg)
Lars Juhl Jensen jensenlab.org
Introduction to text mining!
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>10 km
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patent literature
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grant proposals
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too much to read
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computer
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as smart as a dog
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teach it specific tricks
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named entity recognition!
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dictionary
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genes / proteins
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diseases / phenotypes
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drugs / metabolites
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synonyms
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alpha-synuclein
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SNCA
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PARK1
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not comprehensive
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orthographic variation
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spaces and hyphens
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alpha-synuclein
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alpha synuclein
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prefixes and suffixes
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SNCA
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hSNCA
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alternative forms
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Parkinson’s disease
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Parkinson’s disorder
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Parkinson’s syndrome
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acronyms
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PD
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curated blacklist
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SDS
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software
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C++ tagger
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>1000 abstracts / second
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70–80% recall
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80–90% precision
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open source bitbucket.org/larsjuhljensen/tagger/
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Docker hub.docker.com/r/larsjuhljensen/tagger/
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web service tagger.jensenlab.org
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EXTRACT extract.jensenlab.org
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information retrieval!
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three approaches
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ad hoc retrieval
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PubMed
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text indexing
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document similarity
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recommendation engines
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term vectors
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weighting scheme
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vector similarity
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NER-based retrieval
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synonyms
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alpha-synuclein
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SNCA
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ontologies
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Parkinson’s disease
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neurodegenerative disease
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concept indexing
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improved recall
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too much to read
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information extraction!
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two approaches
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natural language processing
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syntactic parsing
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Gene and protein names Cue words for entity recognition Verbs for relation extraction [nxexpr The expression of"
[nxgene the cytochrome genes" [nxpg CYC1 and CYC7]]]"is controlled by"[nxpg HAP1]
Saric et al., Proceedings of ACL, 2004
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manually crafted rules
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a lot of work
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machine learning
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manually annotated corpus
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even more work
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co-mentioning
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counting
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within document
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within paragraph
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within sentence
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weighted count
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normalization
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z-scores
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database resources
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STRING
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string-db.org
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STITCH
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stitch-db.org
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COMPARTMENTS
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Binder et al., Database, 2014 compartments.jensenlab.org
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TISSUES
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Palasca et al., Database, 2018 tissues.jensenlab.org
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DISEASES
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knowledge discovery!
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indirect associations
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Raynaud’s disease
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blood viscosity
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fish oil
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open discovery
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one-node search
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A → B → C
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generate novel hypotheses
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too many hypotheses
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closed discovery
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two-node search
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A → B ← C
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find plausible explanations
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experimental observation
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trend discovery
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unknown patterns
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known individual facts
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enrichment analysis
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temporal patterns
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conclusions!
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broadly applicable
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keep it simple
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free tools
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