iomics research
TRANSCRIPT
iOMICS ResearchA Unified Software for Microarray and NGS Data Analysis and Interpretation
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iOMICS: Omics Software Solution
Apps for every data (omics) type
Intuitive Analysis
Dynamic Visualization
Support proprietary and 3rd party softwares and databases
Multi-omics Multi-scale data management, analysis, and interpretation software.
Developed for composite analysis needs and tested with numerous data sets, this robust platform addresses the complexities of Life Sciences “Big Data” for driving actionable insights with unprecedented ease.
RESTful
iOMICS
dbNSFP, dbSNP, Uniref100, Uniprot, HumDiv, HumVar,
Ensemble, RefSeq, miRBase KEGG, Interactome, etc
Annotated VariationsEnriched PathwaysPeaks and MotifsKnown and putative genesDifferential Gene ExpressionKnown and Putative miRNAPotential Drug TargetsPhenotype-specific BiomarkersStratified Patient GroupsOff-target effects
App StoreDNA RNA ChIP miRNA
Exome MicroArray MetaGenome
IntegrativeBiology
Ion Torrent, Illumina, Affymetrics, Agilent
PhenotypeModeling
iOMICS: High Level Architecture
FASTQ
CEL
SAM/BAM
CSV/TSV
VCF
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Drug TargetIdentification
PatientStratification
iOMICS: Scalable, Customizable, Flexible
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Flexible and easy to use user interface (UI)
Raw data to results in three steps
– Create
– Analyze
– Visualize
Checkpoint and Re-start
Fast and efficient workflows to process hundred's of samples
Data store to manage high-through put data
Easy integration and customization of in-house, 3rd party tools,
annotations, and databases
Cloud and On-premise versions
iOMICS Research : Applications for Data Analysis
Note: ** - iOMICS Research 4.0
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iOMICS 4.0: Significant Features
Indepth Pathway Analysis
Multi-Omics DataIntegration
Advanced BiologicalFilters
Sophisticated NetworkAnalysis
High to low level visualization of all types of biological pathways based on the experiment
Visualization includes genes, proteins, metabolites, reactions and complexes
Integration of multi-omics datasets to simulate the genetic flow of information associated with the phenotypes
Powerful statistical tools such as Linear regression, Anova, LASSO etc are used for integrative analysis
User defined filters on all results for easier biological interpretation Built in biologically relevant filters for variant prioritization using
annotated information
Complex network analysis such as clustering, shortest path, hubs and topological proeprties of networks
Helps to identify significant biomarkers from large networks
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iOMICS Research: v 4.0New Apps
miRNA Expression : Expression analysis of small non-coding RNA molecules and finding target genes for significantly expressed miRNAs. Currently supports affymetrix and processed expression (Series Matrix) format.
Gene Expression: Analysis of RNA molecule and to identify the significantly expressed genes between the conditions. Significantly enriched genes are further used for functional enrichment analysis.
ChIP on chip: To determine the DNA binding sites from the data generated from microarray experiments.
RNA-Seq Denovo – Applications particularly for novel organismsRAD-Seq – Reduced representtion sequencing for identification of marker
linked variationsMetagenome- 16srRNA and shot gun metagenome for species composition
and functional analysis.QTL - To identify the loci which correlates with variation in a phenotype.Integrative Biology - Integrative analysis of DNA-RNA, ChIP-RNA and
miRNA-RNA to find out the key components (DNA, ChIP and miRNA) resulting in RNA change. This workflow requires cohort-wide results from multiple molecular data.
iOMICS Research: v 4.0Enhancements
BAM/SAM, VCF input supportGenerate Exonic coverage, Target region coverage, % of exome enriched
and probe enriched statistics for each sampleLinkage annotation of variations that are closely related with dissemination
of disease in a familyAssess disease-gene networkMore annotations using genome browserMendelian disease filtersMore annotations for Gene Ontology and Pathway analysisCase control analysisNarrow and broad peaks categorizationMore statistics on peak results to extract more biological insightsGenerate correlation between common peaks among all the replicatesFusion Transcript identificationmiRNA Analysis for plantAdvanced filters
iOMICS Research: Data Store
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Administer, Manage and Share data with Collaborators
JNCASR
Some Of Our Customers
Thank You
Corporate OfficeShezan Lavelle, 5th Floor,#15, Walton Road,Bangalore – 560 001,Karnataka, India.Email: [email protected]: +91 (0)80 4662 3800Website: www.interpretomics.co Corporate Office: USAInterpretOmics, Inc.#5 Parker Street, LexingtonMA 02421, USAEmail: [email protected]: 415-800-4515URL: www.interpretomics.co Genomic Sequencing Lab: IndiaInterpretOmics Center for Next Generation Sequencing#329 7th Main, 80 Ft Road, Indiranagar, HAL II StageBangalore – 560 008