ionophores
TRANSCRIPT
Er. Manoj ShresthaEngineer and Research Scientist
AREC-NEPAL, BMEAC-Research Center
07.05.2009
IonophoresIonophores are small, lipid soluble molecules that allow specific ions to permeate the membrane.Small carrier molecules Any of a group of organic compounds Any molecule as of a drug Increase the permeability of cell membrane
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IonophoresHydrophobic Molecule Lipid-Soluble Molecule Solvent for the Ion Carboxylic Polyether Antibiotics
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Ionophores
Hydrophilic Medium
Hydrophobic Medium
Ions05/08/09 4
IonsLi+ Na+ K+ Mg2+ Ca2+
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Ionophores
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Types of IonophoresIonophores
Channel forming Ionophores
Mobile Ion Carriers (small molecules)
Gramicidin to Depolarize Cells
Ionomycin to Hyperpolarize Cells
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Carrier Ionophores
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Ion Transport by Ionophores
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Naturally Occurring Ionophores IonophoresPeptide Cyclic Depsipeptide Macrotetrolide Polyether Ionophores
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ValinomycinCyclic peptide. Acts as an antibiotic ionophore. Carries of 105 K+/sec across membranes.
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GramicidinShort dimeric peptide. Act as an antibiotic ionophore. Carries of 107 potassium. Na+ per second across membranes. To depolarize cells.
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ReferencesDictionary of Cell and Molecular Biology by Robert C. Hine Mc Graw Hill Medical Dictionary for Allied Health by Myrna Breskin, Enid Pearsons http://www.mondofacto.com http://www.emdbiosciences.com/SharedImages/TechinicalLiter ature/1_CB0583_iono.pdf http://en.wikipedia.org/wiki/Ionophore
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Thank You For Listening!
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