ions and isotopes
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Ions and Isotopes. Ions have charge Cations + Anions - Isotopes vary in mass Neutrons Radioisotopes Unstable nuclei Emit energy -radiation Medical uses as tracers and treating disease. Four Primary Types of Ionizing Radiation: Alpha Particles. - PowerPoint PPT PresentationTRANSCRIPT
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Ions have charge– Cations +– Anions -
Isotopes vary in mass– Neutrons– Radioisotopes
Unstable nuclei Emit energy -radiation Medical uses as tracers and treating disease
Ions and IsotopesIons and Isotopes
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Alpha Particles: 2 neutrons and 2 protonsThey travel short distances, have large massOnly a hazard when inhaled
Four Primary Types of Four Primary Types of Ionizing Radiation:Ionizing Radiation:
Alpha ParticlesAlpha Particles
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Four Primary Types of Four Primary Types of Ionizing Radiation:Ionizing Radiation:
Beta ParticlesBeta ParticlesBeta Particles: Electrons or positrons having small mass and variable energy. Electrons form when a neutron transforms into a proton and an electron or when a proton transforms into a positron and a neutron:
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Four Primary Types of Four Primary Types of Ionizing Radiation:Ionizing Radiation:
Gamma RaysGamma Rays
Gamma Rays (or photons): Result when the nucleus releases
Energy, usually after an alpha, beta or positron transition
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Four Primary Types of Four Primary Types of Ionizing Radiation:Ionizing Radiation:
X-RaysX-Rays
X-Rays: Occur whenever an inner shell orbital electron is removed
and rearrangement of the atomic electrons results with the release of
the elements characteristic X-Ray energy
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Four Primary Types of Four Primary Types of Ionizing Radiation:Ionizing Radiation:
NeutronsNeutrons
Neutrons: Have the same mass as protons but are uncharged
They behave like bowling balls
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Four Primary Types of Four Primary Types of Ionizing RadiationIonizing Radiation
Alpha particlesBeta particlesGamma rays (or photons)X-Rays (or photons)Neutrons
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Ionization Ionization Ionization Ionization
Ionizing radiation is produced by unstable atoms. Unstable atoms differ from stable atoms because they have an excess of energy or mass or both.
Unstable atoms are said to be radioactive. In order to reach stability, these atoms give off, or emit, the excess energy or mass. These emissions are called radiation.
Ionizing radiation is produced by unstable atoms. Unstable atoms differ from stable atoms because they have an excess of energy or mass or both.
Unstable atoms are said to be radioactive. In order to reach stability, these atoms give off, or emit, the excess energy or mass. These emissions are called radiation.
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Types or Products of Ionizing Types or Products of Ionizing RadiationRadiation
Types or Products of Ionizing Types or Products of Ionizing RadiationRadiation
or X-
rayneutron
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DNA and RadiationDNA and Radiation
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Ionizing Radiation at the Ionizing Radiation at the Cellular LevelCellular Level
Causes breaks in one or both DNA strands or;
Causes Free Radical formation
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Commonly Transported Commonly Transported RadioisotopesRadioisotopes
Americium-241= Diagnose thyroid disorders, smoke detectors.
Cesium-137= Cancer treatment.Iodine-125,131= Diagnosis & treatment
liver, kidney,heart, lung and brain.Technetium-99m=Bone and brain imaging;
thyroid and liver studies; localization of brain tumors.
Americium-241= Diagnose thyroid disorders, smoke detectors.
Cesium-137= Cancer treatment.Iodine-125,131= Diagnosis & treatment
liver, kidney,heart, lung and brain.Technetium-99m=Bone and brain imaging;
thyroid and liver studies; localization of brain tumors.
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radrad
1 rad = 1 Roentgen
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remrem
The unit of dose equivalent for any type of ionizing radiation absorbed by body tissue in terms of estimated biological effect - Unit of dose equivalent
Dose in health record is in units of rem1 rem = 1 Roentgen1 Sievert (Sv) = 100 REM1 mSv = 100 mREM
Roentgen Equivalent Man
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Quality Factor (Q)Quality Factor (Q)
The specific value that accounts for the ability of different types of ionizing radiation to cause varying degrees of biological damage– X-rays, gamma rays, & beta particles 1– Neutrons & High energy protons 10– Alpha Particles 20
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Units of RadioactivityUnits of Radioactivity
Curie (Ci) = 2.22 E12 dpm or 3.7E10 dpsBecquerel (Bq) = 1 dpsMaximum Dose/year = 5 REM or 50 mSvMaximum Dose/year for Declared Pregnant
Woman & Minors= 0.5 REM or 5 mSv
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Half Life CalculationHalf Life Calculation
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Annual Dose LimitsAnnual Dose LimitsExternal/Internal Exposure Limits for Occupationally Exposed Individuals
Adult ($18 yrs) Minor (< 18 yrs)
Whole body* 5000 mrem/yr 500 mrem/yr
Lens of eye 15000 mrem/yr 1500 mrem/yr
Extremities 50000 mrem/yr 5000 mrem/yr
Skin 50000 mrem/yr 5000 mrem/yr
Organ 50000 mrem/yr 5000 mrem/yr
*Effective dose equivalent
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Dose Response RelationshipsDose Response Relationships
0-150 rem—No or minimal symptoms150-400 rem—Moderate to severe illness400-800 rem—Severe illness deaths start
above 500 remAbove 800 rem—Fatal
***Acute whole body doses
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Your Annual ExposureYour Annual ExposureActivity Typical Dose
Smoking 280 millirem/year
Radioactive materials use in a UM lab
<10 millirem/year
Dental x-ray 10 millirem per x-ray
Chest x-ray 8 millirem per x-ray
Drinking water 5 millirem/year
Cross country round trip by air 5 millirem per trip
Coal Burning power plant 0.165 millirem/year
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Subjects Total subjects (n)
Subjects undergoing more than 1 procedure (%)
Mean annual effective dose from procedures (mSv)
All subjects 952 420 68.8 2.4
•Males 453 078 57.9 2.3
•Females 499 342 78.7 2.6
•18–34 y 233 586 49.5 1.0
•35–39 y 118 365 65.7 1.6
•40–44 y 144 728 72.1 2.0
•45–49 y 146 703 74.9 2.6
•50–54 y 131 209 78.2 3.3
•55–59 y 115 520 79.5 4.1
•60–64 y 62 309 85.9 5.2
Effective doses of ionizing radiation from medical Effective doses of ionizing radiation from medical proceduresprocedures
Fazel R et al. N Engl J Med 2009; 361: 849-57.
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Procedure Average effective dose (mSv)
Proportion of the total effective dose from all study procedures (%)
Myocardial perfusion imaging 15.6 22.1CT of abdomen 8 18.3CT of pelvis 6 12.2CT of chest 7 7.5Diagnostic cardiac catheterization 7 4.6Radiography of the lumbar spine 1.5 3.3Mammography 0.4 3.1CT angiography of the chest (noncoronary)
15 3.1
Upper gastrointestinal series 6 2.4CT of head or brain 2 2.0PCI 15 1.8
Medical imaging procedures with largest Medical imaging procedures with largest contribution to cumulative effective dosecontribution to cumulative effective dose
Fazel R et al. N Engl J Med 2009; 361: 849-57.
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Estimated Exposure To The Estimated Exposure To The National PopulationNational Population
Between 320 – 360 mr/yrBetween 320 – 360 mr/yr