is this specific for zebrafish? or can we learn how to drive stem cells into specific cell types in...
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![Page 1: Is this specific for zebrafish? Or can we learn how to drive stem cells into specific cell types in mammals?](https://reader034.vdocument.in/reader034/viewer/2022051618/56649c875503460f9493f505/html5/thumbnails/1.jpg)
Is this specific for zebrafish?
Or can we learn how to drive stem cells into specific cell types
in mammals?
![Page 2: Is this specific for zebrafish? Or can we learn how to drive stem cells into specific cell types in mammals?](https://reader034.vdocument.in/reader034/viewer/2022051618/56649c875503460f9493f505/html5/thumbnails/2.jpg)
Overexpression of mouse Pou5f1 rescues zebrafish embryos mutant for Pou5f1
Evolutionary conservation of function
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Overexpression of mouse Pou5f1 rescues zebrafish embryos mutant for Pou5f1
Evolutionary conservation of function
Mouse and zebrafish Pou5f1 share targets:
Comparison with mouse Oct4 target sets(genes with homology info only):Sharov et al, BMC Genomics 2008(Matoba et al., 2006 and Loh et al., 2006)
453 49 406
zebrafish mouse
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Relevance?
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Insight into controlled differentiation of stem cells to replace lost tissues:
Regenerative medicine
Use knowledge of combination of tissue specific repressors of
differentiation to generate defined cell types
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Acknowledgements
& Rebecca Mössner, Kay Kotkamp, Bozena Polock, Björn Wendik, Esther Kur, Bernadette Lippok, Sungmin Song, Heinz-Georg-Belting, Martina Lachnit
Collaborations: Thorsten Kurz (ZBSA Genomics Core)
Daria Onichtchouk Florian Geier Jens Timmer (FRIAS)
Onichtchouk et al., Molecular Systems Biology, 6:354 Mar 9 - 2010
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