ishlt international registry for heart and lung

http://www.jhltonline.org

Figure 1 Countrcollaborative data s

1053-2498/$ - see fronhttp://dx.doi.org/10.10

E-mail address: jos

Reprint requests: JN Medical Dr, 4A100

ANNUAL ISHLT REGISTRY REPORTS

ISHLT International Registry for Heart and LungTransplantation—Into the Fourth Decade, From Strength toStrength

Josef Stehlik, MD, MPH,a,b Jeffrey D. Hosenpud, MD,c Leah B. Edwards, PhD,a,d Marshall I. Hertz, MD,e and Mandeep R. Mehra, MDf;for the International Society for Heart and Lung Transplantation

From the aISHLT Transplant Registry, Dallas, Texas; bthe U.T.A.H. Cardiac Transplant Program, University of Utah School of Medicine,Salt Lake City, Utah; cthe Department of Transplantation, Mayo Clinic, Jacksonville, Florida; dthe United Network for Organ Sharing,Richmond, Virginia; ethe Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Minnesota, Minneapolis,Minnesota; and the fthe Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts.

This year, the ISHLT International Registry for Heart andLung Transplantation enters into its fourth decade. Withdata from more than 160,000 thoracic transplant recipients,the Registry is the largest repository of heart and lungtransplant data in the world.

ies participating in the ISHLT International Registryubmission; yellow flag indicates direct submission o

t matter Published by Elsevier Inc.16/j.healun.2013.08.009

[email protected]

osef Stehlik, MD, MPH, University of Utah Health SciencesSOM, Salt Lake City, UT 84132. Telephone: 801-585-234

The Registry has had an interesting and somewhattumultuous history. One of the authors, Jeffrey Hosenpudwas directly involved in its earliest times. His first directinvolvement was in 1988 when, after performing atransplant in a patient with amyloid light-chain (AL)

for Heart and Lung Transplantation. Red flag indicates national orf data by individual centers.

Center, Division of Cardiology, U.T.A.H. Cardiac Transplant Program, 500. Fax: 801-581-7735.

http://www.jhltonline.org

dx.doi.org/10.1016/j.healun.2013.08.009



mailto:[email protected]

The Journal of Heart and Lung Transplantation, Vol 32, No 10, October 2013942

amyloidosis—at the time considered an absolute contra-indication to transplantation, he wanted to know if therewere other patients who had received transplants for thatdisease. Hosenpud flew to San Diego to meet withDr Mike Kaye, the first Registry director, and “queried”the Registry, which was an Excel spreadsheet with abouthalf the patient data entered, and several boxes of indexcards that were gone through by hand. Despite the not quiteoptimal organization of the data, several other patients withAL-chain amyloidosis were identified, and this series wasultimately published.1

In the United States, the United Network for OrganSharing (UNOS) was awarded the government contract forthe Organ Procurement and Transplantation Network(OPTN) in 1986 and the Scientific Registry of TransplantRecipients (SRTR) contract in 1987. Kaye was instrumentalin developing the data collection instrument for the UNOSThoracic Registry (basing it primarily on the ISHLTRegistry) and coordinated data submission to the Registrythrough UNOS. As submission of data to UNOS wasmandated in the United States, the quality of the ISHLTRegistry data also immediately improved. Unfortunately,the relationship between UNOS and the Registry was not allhoney and roses: Conflicts arose regarding additional datacollection, timely submission of data from UNOS to theRegistry, cost, and oversight issues. This friction ultimatelyled the ISHLT Board to sever relations with UNOS in 1990,and ISHLT began the process of getting United Statescenters to once again submit data separately.

As the UNOS Scientific Advisory Committee ViceChair, Hosenpud was the de facto UNOS Thoracic RegistryDirector starting in 1991. He received an unexpected callfrom the ISHLT President Dr Billingham expressing regretabout the separation of the 2 registries. There was alsoresistance from United States transplant centers regardingthe request to submit similar data to 2 registries. Billinghamwondered if the relationship could be repaired and requesteda “secret” meeting in Chicago, which included Billingham,ISHLT Board Member John B. O’Connell, UNOS Execu-tive Director Gene Pierce, UNOS Assistant ExecutiveDirector Walter Graham, and Hosenpud. They agreed towork behind the scenes to bring the 2 organizations andregistries back together, which was ultimately accom-plished.

Hosenpud was appointed the ISHLT Registry Director in1993, and his first official accomplishment was obtainingadditional funding from the ISHLT to contract with UNOSfor all data collection and a yearly data analysis and slidegeneration. ISHLT Registry data were electronicallyintegrated and maintained separately from UNOS data as aunique database. The first report and slides analyzed andgenerated in collaboration with UNOS was the 1994Registry report.2 In 1997, Dr Mark Boucek was namedthe Associate Registry Director, with responsibility forpediatric data, and separate pediatric and adult Registryreports were initiated.

Under the tenure of Marshall Hertz, the Registry SteeringCommittee was expanded, and generation of separate organ-specific reports was initiated. Over the coming years,

collaborative efforts were established between the Registryand 6 other data exchange organizations around the worldthat now submit data to ISHLT through regular data transfers(Appendix). Additional countries in Europe, Asia, North andSouth America, and Africa, where centralized data submis-sion is not (yet) possible, participate in the Registryindividually, through Web-based data entry. More than 280centers from 33 countries currently participate in the Registry.

The above retrospective, and conclusion of anotherdecade of work, provides an opportunity to pinpoint thefactors that have contributed to the Registry’s success. Webelieve the following have been key in this process:

1.
Operation of the Registry by an international professionalsociety that represents multiple stakeholders in thoracictransplantation. The ISHLT has provided not only thelogical “home” for the Registry but also the logistical andfinancial support that has shielded the Registry fromfinancial and other uncertainties of the ever-changinghealth care environment.
2.
Inclusion of both the pediatric and adult populations. 3. Aggressive pursuit of truly international participation
(Figure 1).
4. Flexibility of the Registry in allowing different arrange-
ments for data entry while maintaining the necessaryquality standards. The Registry has developed mechan-isms for efficient data entry from individual centers, fortransfer of data from national registries, and for transferof data from registries of country collectives.3

5.
Establishing a clear governance and workforce structurethrough the Registry Steering Committee (Table 1), withdefined responsibilities and expectations.
6.
Maintaining strong statistical core, directed by LeahEdwards, PhD, which provides year-round support toRegistry work.
7.
Partnership with the Journal of Heart and LungTransplantation. The Registry reports provide the readerswith yearly updates on the developments in the field ofthoracic transplantation, and the Registry output is thuswidely disseminated.4–7 The Registry slides, available toISHLT members, are abundantly used in scientificpresentations. The high—and currently increasing—rateof citations of the ISHLT reports and other Registrystudies in peer reviewed publications demonstrates thewidespread and growing importance of the Registry datato our field. For illustration, the single 2001 Registryreport8 has since received 676 citations, a rate of 56citations per year. The 2010 Registry report series,consisting of an introduction and 4 organ-specificreports,9–13 has been cited 608 times, at a running rateof 202 citations per year. Similarly, the Registry dataanalyses have influenced formulation of recommenda-tions in clinical practice guidelines, further impactingclinical care.14–21
After 3 decades, the Registry remains very relevant to oureveryday practice, and this has been further boosted byrecent developments in our field. The expanding use ofmechanical circulatory assist in advanced heart failure,

Stehlik et al. ISHLT Registry - Into The 4th Decade 943

clinical application of ex vivo organ perfusion, increasingacceptance of donation after circulatory death (DCD) inlung transplantation, successful implementation of ABO-incompatible transplantation, and other emerging clinicalapproaches are changing the questions we ask of theRegistry. Further, the rapid global growth of heart and lungtransplantation represents additional opportunities for expand-ing the Registry and starting new collaborations. Now underthe direction of Josef Stehlik, the Registry continues to evolve,and innovative approaches to answer the needs of the thoracictransplant community are being pursued. Examples of recentand planned Registry work include:

�

Table 1 Steering Committee and Staff of the ISHLT

Presentation of results from a DCD Mini-registry at the2013 ISHLT Annual Scientific Sessions in Montreal.22

The “mini-registry” approach allows investigators from agroup of centers with a special interest in a particularclinical question to design a focused database wheresupplementary data pertinent to the topic of interest arecollected on existing transplants in the Registry, so thatdetailed follow-up information is already available forthese patients in the main Registry. Centers from Canada,Europe, Australia, and the United States are currentlyparticipating in the DCD Mini-registry.

International Registry for Heart and Lung Transplantation
�
Steering Committee Position

Josef Stehlik, MD Medical DirectorJason Christie, MD Associate Director, Lung

TransplantationRoger Yusen, MDa Associate Director, Lung

TransplantationChristian Benden, MD Associate Director, Pediatric

Lung TransplantationLars Lund, MDa Associate Director, Heart

TransplantationAnne Dipchand, MD Associate Director,

Pediatric HeartTransplantation

Richard Kirk, MD Associate Director,Pediatric Heart

We continue to promote the Transplant Registry EarlyCareer Awards, which provide an opportunity for juniorinvestigators to obtain access to Registry data whilereceiving financial support to conduct the analyses. Thisis also a natural way for junior members to network withmembers of the Registry steering committee and otherISHLT content experts and so become involved in theSociety’s core activities. This mechanism has funded 12junior investigators since 2007 (Table 2), and 2 presentedtheir work at the annual sessions this year.23,24 We wouldlike to encourage junior investigators, especially thosefrom non-North American programs, to explore thedata elements posted on the Registry Web site andconsider submitting an application for a 2014 Award(http://www.ishlt.org/awards/awardTxRegistry.asp, deadline in January 2014).

Transplantation
� Axel Rahmel, MD Associate Director,
OEO and TransplantCenter Relations

FabienneDobbels, PhD Associate Director,Outcomes Analysis

Leah Edwards, PhD Associate Director,Data Analysis

Amanda Rowe ISHLT Executive DirectorStaffKathryn Philibin, RN ISHLT Registry AdministratorFrank Gilg Director, TII InformatixJaime Williamson Data Analyst

Thoracic transplantation is gradually gaining ground inregions that have not traditionally been among the coregeographic areas in our field. The ISHLT is greatlyinterested in the active participation of transplantprofessionals from these countries in our Society. TheRegistry provides a platform for international collabora-tions and for learning from each other’s experiences. Lastyear we welcomed new centers from Brazil, Estonia,Poland, Turkey, and Iran to the family of more than 280centers from 33 countries worldwide that participate inthe Registry. Continued efforts will be directed at furtherexpansion of the Registry’s member base.

Figure 2 New ISHLT Registry logo.

�
This year we introduce a new feature to our annualReports. In addition to providing the core informationregarding demographics, immunosuppression, and out-comes, a focus theme will explore a defined topic in moredetail every year. The 2013 report explores age as animportant donor and recipient variable and its effect on thetransplant process and outcomes. In addition to informa-tion presented in the printed version of the reportspublished in this issue of the Journal, an online Registrydata set, complete with a brand new Registry logo(Figure 2), also offers a number of expanded focus themeanalyses.25
We hope we are starting off another successful decadefor the Registry. We sincerely thank ISHLT members, staffat participating hospitals, and staff at data exchangeorganizations for their active support (Appendix 1). Withoutthis enthusiastic support the ISHLT International Registryfor Heart and Lung Transplantation would have longdeparted.

Anna Kucheryavaya, MS Assistant BiostatisticianSusan Groff ISHLT Support CoordinatorJo Smith ISHLT Support Coordinator

ISHLT, International Society for Heart and Lung Transplantation;OEO, organ exchange organization.

aNewly appointed members of the Steering Committee.

http://www.ishlt.org/awards/awardTxRegistry.asp

Table 2 Transplant Registry Early Career Award Recipients

2007 Institution Research

Beth D. Kaufman, MD The Children's Hospital of Philadelphia,Philadelphia, PA

Influence of Nutritional Status on Outcomes inPediatric Heart Transplantation

2008Cynthia Gries, MD, MSc University of Washington, Seattle, WA Development of a Predictive Model for Long

Term Survival in Lung TransplantationScott Halpern, MD, PhD University of Pennsylvania, Philadelphia,

PADecision Analysis of Single versus Double LungTransplant for Patients with COPD

Josef Stehlik, MD, MPH University of Utah School of Medicine, SaltLake City, UT

Interactions Among Donor and RecipientCharacteristics and Their Impact on Post-Transplant Survival

2010Jennifer Conway, MD, FRCPC Hospital for Sick Children, Toronto, Canada Survival Outcomes and Long Term Morbidities in

Children Undergoing RetransplantationKiran K. Khush, MD, MAS Stanford University School of Medicine,

Stanford, CADoes Sex Matter? Investigating the Impact ofDonor and Recipient Sex on Outcomes AfterHeart Transplantation

2011Jose Nativi, MD University of Utah, Salt Lake City, UT Post Transplant Outcomes of Patients Requiring

Biventricular Mechanical Bridge to Transplant2012

Erin M. Lowery, MD Loyola University Medical Center,Maywood, IL

Risk Factors for the Development of PTLD inPatients with Cystic Fibrosis Following LungTransplantation

Omar Wever-Pinzon, MD University of Utah, Salt Lake City, UT Impact of Recipient Age on Differential Causesof Heart Transplant Mortality

2013Chesney Castleberry, MD Cincinnati Children's Hospital, Cincinnati,

OHmTOR Inhibitors in Pediatric HeartTransplantation: Do the potential benefitsoutweigh the risks?

Aaron Healy, MD University of Utah, Salt Lake City, UT Predictors of Post-Transplant Outcomes inPatients Bridged to Transplantation withContinuous-Flow LVADs

Eugene DePasquale, MD UCLA, Los Angeles, CA Influence of Chronic Kidney Disease Stage onPatient Selection for Heart and Heart-KidneyTransplantation

COPD, chronic obstructive pulmonary disease; LVAD, left ventricular assist device; mTOR, mammalian target of rapamycin; PTLD, post-transplantlymphoproliferative disorder.


Disclosure statement

The authors thank Dr Michael Kaye, the first Registry director, forhis important contributions.

Appendix List of Thoracic Transplant Centers Reporting Data To the IRegistry for transplants performed between January 1, 2011 and Jun

Country (ISO code) Center

Argentina (ARG) Fundacion FavaloroHospital Italiano

Australiaa (AUS) St. Vincent’s HospitalThe Royal Children’s HospitalThe Prince Charles HospitalThe Alfred HospitalRoyal Perth Hospital

Austriab (AUT) Allgemeines Krankenhaus WienUniversitätsklinik InnsbruckLandeskrankenhaus Graz

All relevant disclosures for the authors are on file with theISHLT and can be made available for review by contacting theExecutive Director of the ISHLT.

nternational Society for Heart and Lung Transplantation Transplante 30, 2012

Continued on page 945

Belgium b (BEL) Hôpital Erasme BruxellesUniversitair Ziekenhuis AntwerpenOnze Lieve Vrouw Ziekenhuis AalstUniversitair Ziekenhuis GentCentre Hospitalier Universitaire LiègeCliniques Universitaires, Université Catholique de LouvainUZ Gasthuisberg Leuven

Brazil (BRA) Heart Institute—Universidade de São PauloHospital de MessejanaReal Hospital Português de Beneficiéncia em PernambucoInstituto de Cardiologia do Distrito Federal

Canada (CAN) Royal Victoria HospitalThe Toronto General HospitalQuebec Heart Institute—Laval HospitalOttawa Heart InstituteUniversity of Alberta Hospitals/Walter C. Mackenzie Health SciencesThe Hospital For Sick Children

Chile (CHL) Instituto Nacional del ToraxColombia (COL) Clinica Cardiovascular

Fundacion Valle Del LiliFundacion Cardioinfantil—Instituto de CardiologiaFundacion Cardiovascular de ColombiaFundacion Clinica Shaio

Croatia2 (HRV) University Clinical Hospital ZagrebUniversity Hospital Dubrava

The Czech Republic (CZE) University Hospital MotolDenmark3 (DNK) Skejby University Hospital

Rigshospitalet, National University HospitalEstonia (EST) Tartu University HospitalFinlandc (FIN) Helsinki University Central Hospital

Children’s Hospital, University of HelsinkiFranced (FRA) Marseille Sainte Marguerite (APM) (A)—Chirurgie Thoracique

Marseille Timone adultes (APM) (A)—Chirurgie CardiaqueMarseille Timone enfants (APM) (AþP)—Chirurgie Cardio-VasculaireCaen (A)—Chirurgie CardiaqueDijon (A)—Chirurgie CardiaqueToulouse (A)—Chirurgie ThoraciqueToulouse (A)—Chirurgie Cardio-VasculaireBordeaux (AþP)—Unite de Transplantation CardiaqueBordeaux (AþP)—Chirurgie ThoraciqueMontpellier (A)—Unite de Transpl. Cardio-thoraciqueRennes (A)—Centre Cardio-PneumologiqueTours (AþP)—Chirurgie CardiaqueGrenoble (A)—Chirurgie CardiaqueGrenoble (A)—PneumologieNantes (AþP)—Chirurgie Cardio-VasculaireNancy (AþP)—Chirurgie Cardio-PulmonaireLille (AþP)—Chirurgie Cardio-VasculaireClermont-Ferrand (A)—Chirurgie CardiaqueStrasbourg (A)—Chirurgie ThoraciqueStrasbourg (A)—Chirurgie Cardio-PulmonaireLyon (AþP)—Pole de Transplantation PulmonaireLyon I (HCL) (AþP)—Pole de Transplantation CardiaqueLyon II (HCL) (A)—Pole De Transplantation CardiaqueParis Pitié-Salpêtrière (AP-HP) (AþP)—Chirurgie Cardio-VasculaireParis Necker Enfants Malades (AP-HP) (AþP)—Cardiologie PediatriqueClichy Beaujon (AP-HP) (A)—Pneumologie B et Transplantation PulmonaireParis Bichat (AP-HP) (A)—Chirurgie Cardio-Vasculaire

Appendix (Continued)




Paris Georges Pompidou (AP-HP) (A)—Transplantation CardiaqueParis Georges Pompidou (AP-HP) (AþP)—Transplantation Pulmonaire et Cardio-PulmonaireRouen (AþP)—Chirurgie Thoracique Et Cardio-VasculaireLimoges (A)—Chirurgie CardiaqueSuresnes Foch (A)—Chirurgie ThoraciqueLe Plessis-Robinson Marie-Lannelongue (AþP)—Chirurgie CardiaqueLe Plessis-Robinson Marie-Lannelongue (AþP)—Chirurgie Thoracique Cardio-VasculaireCréteil Henri Mondor (AP-HP) (A)—Chirurgie Cardio-Vasculaire

Germanyb (DEU) Universität des Saarlandes Homburg/SaarHerzzentrum Dresden GmbHDeutsches Herzzentrum BerlinUniversitätsklinik KölnUniversität Leipzig—HerzzentrumKerckhoff Klinik, Bad NauheimKlinikum der Universität RegensburgHerzzentrum Nordrhein-Westfalen Bad OeynhausenUniversitätsklinikum EssenJohannes Gutenberg Universität MainzHeinrich-Heine-Universität DüsseldorfUniversitätsklinikum MünsterRuprecht-Karls-Universität HeidelbergMedizinische Hochschule HannoverUniversitätsklinikum GöttingenUniversitätsklinikum AachenKlinikum der Justus-Liebig-Universität GiessenUniversitätsklinikum Schleswig-Holstein KielFriedrich Schiller Universität JenaFriedrich Alexander Universität ErlangenUniversitätsklinikum WürzburgLudwig Maximilians Universität MünchenUniversitätsklinikum HamburgKlinikum der Albert-Ludwigs-Universität Freiburg im Breisgau

Iran (IRN) Cardiac Surgery and Transplantation Research CenterIrelande (IRL) Mater HospitalIsrael (ISR) Rabin Medical Center (Belinson Campus)

Sheba Medical CenterItaly (ITA) Policlinico S. Orsola—Universitadegli StudiJapan (JPN) Tohoku University Hospital

Osaka University HospitalKyoto University HospitalSaitama Medical School Hospital

Netherlandsb (NLD) Universitair Medisch Centrum UtrechtErasmus Medisch Centrum RotterdamUniversitair Medisch Centrum Groningen

New Zealand (NZL) Auckland City HospitalNorwayc (NOR) Rikshospitalet—National Hospital of NorwayPoland (POL) Regional Pulmonary HospitalThe Republic of Korea (KOR) Gangnam Severance HospitalSloveniab (SVN) University Medical Center LjubljanaSouth Africa (ZAF) Milpark HospitalSpain (ESP) Complejo Hospitalario Universitario Juan Canalejof,g

Hospital Universitario Marques de Valdecillaf,h

Hospital de Bellvitge. Barcelonah

Hospital Virgen Del Rocio, Sevillah

Hospital Santa Creu I Sant Pau, Barcelonah

Hospital Universitario 12 de Octubref,h

Hospital Universitario Reina Sofiaf,h

Hospital Gregorio Marañón, Madridh





Hospital Universitario Puerta de Hierrof

Hospital Universitari I Politècnic La Fe, Valenciaf,h

Hospital Clinic I Provincial, Barcelonah

Hospital Universitario Vall D’Hebronf,h

Hospital Central de Asturiasg

Hospital La Paz. Madrid. Niñosh

Hospital Virgen de La Arrixaca, Murciah

Hospital Miguel Servet, Zaragozah

Hospital Clínico, Valladolidh

Swedenc (SWE) Sahlgrenska University HospitalUniversity Hospital of Lund

Switzerland (CHE) University Hospital ZurichCentre Hospitalier Universitaire Vaudois

Turkey (TUR) Heart Center, Ankara UniversityHospital of Akdeniz University

United Kingdome (UK) Great Ormand Street Hospital for ChildrenUniversity of Glasgow/Glasgow Royal InfirmaryThe Freeman HospitalHarefield HospitalWythenshawe HospitalQueen Elizabeth HospitalPapworth Hospital

United Statesi (USA) University of Alabama Hospital, Birmingham, AlabamaBaptist Medical Center, Little Rock, ArkansasArkansas Children’s Hospital, Little Rock, ArkansasMayo Clinic Hospital, Phoenix, ArizonaPhoenix Children’s Hospital, Phoenix, ArizonaSt. Joseph’s Hospital and Medical Center, Phoenix, ArizonaUniversity Medical Center, University of Arizona, Tucson, ArizonaChildren’s Hospital Los Angeles, Los Angeles, CaliforniaCedars-Sinai Medical Center, Los Angeles, CaliforniaLoma Linda University Medical Center, Loma Linda, CaliforniaLucile Salter Packard Children’s Hospital, Palo Alto, CaliforniaCalifornia Pacific Medical Center, San Francisco, CaliforniaUniversity of California San Diego Medical Center, San Diego, CaliforniaUniversity of California San Francisco Medical Center, San Francisco, CaliforniaSutter Memorial Hospital, Sacramento, CaliforniaSharp Memorial Hospital, San Diego, CaliforniaStanford University Medical Center, Stanford, CaliforniaUniversity of California Los Angeles Medical Center, Los Angeles, CaliforniaKeck Hospital of University of Southern California, Los Angeles, CaliforniaChildren’s Hospital Colorado, Aurora, ColoradoUniversity of Colorado Hospital/Health Sciences Center, Aurora, ColoradoHartford Hospital, Hartford, ConnecticutYale New Haven Hospital, New Haven, ConnecticutWashington Hospital Center, Washington, District of ColumbiaAlfred I duPont Hospital for Children, Wilmington, DelawareAll Children’s Hospital, St. Petersburg, FloridaFlorida Hospital Medical Center, Orlando, FloridaMemorial Regional/Joe DiMaggio Children’s Hospital, Hollywood, FloridaJackson Memorial Hospital, Miami, FloridaMayo Clinic Florida, Jacksonville, FloridaTampa General Hospital, Tampa, FloridaShands Hospital at University of FL, Gainesville, FloridaChildren’s Healthcare of Atlanta, Atlanta, GAEmory University Hospital, Atlanta, GAPiedmont Hospital, Atlanta, GASt. Joseph’s Hospital of Atlanta, Atlanta, GA





University of Iowa Hospital and Clinics, Iowa City, IAAdvocate Christ Medical Center, Oak Lawn, IllinoisAnn and Robert H. Lurie Children’s Hospital, Chicago, IllinoisLoyola University Medical Center, Maywood, IllinoisNorthwestern Memorial Hospital, Chicago, IllinoisRush University Medical Center, Chicago, IllinoisUniversity of Chicago Medical Center, Chicago, IllinoisIndiana University Health, Indianapolis, IndianaLutheran Hospital of Ft Wayne, Ft Wayne, IndianaSt. Vincent Hospital and Health Care Center, Indianapolis, IndianaJewish Hospital, Louisville, KentuckyKosair Children’s Hospital, Louisville, KentuckyUniversity of Kentucky Medical Center, Lexington, KentuckyOchsner Foundation Hospital, New Orleans, LouisianaTulane Medical Center, New Orleans, LouisianaBoston Children’s Hospital, Boston, MassachusettsMassachusetts General Hospital, Boston, MassachusettsTufts Medical Center, Boston, MassachusettsBrigham and Women’s Hospital, Boston, MassachusettsJohns Hopkins Hospital, Baltimore, MarylandUniversity of Maryland Medical System, Baltimore, MarylandChildren’s Hospital of Michigan, Detroit, MichiganHenry Ford Hospital, Detroit, MichiganSpeCenterum Health, Grand Rapids, MichiganUniversity of Michigan Medical Center, Ann Arbor, MichiganAbbott Northwestern Hospital, Minneapolis, MinnesotaSt. Mary’s Hospital (Mayo Clinic), Rochester, MinnesotaUniversity of Minnesota Medical Center, Minneapolis, MinnesotaBarnes-Jewish Hospital, St. Louis, MissouriCardinal Glennon Children’s Hospital, St. Louis, MissouriSt. Louis Children’s Hospital, St. Louis, MissouriSt. Luke’s Hospital of Kansas City, Kansas City, MissouriUniversity of MS Medical Center, Jackson, MississippiNorth Carolina Baptist Hospital, Winston-Salem, North CarolinaCarolinas Medical Center, Charlotte, North CarolinaDuke University Hospital, Durham, North CarolinaUniversity of North Carolina Hospitals, Chapel Hill, North CarolinaThe Nebraska Medical Center, Omaha, NebraskaNewark Beth Israel Medical Center, Newark, New JerseyRobert Wood Johnson University Hospital, New Brunswick, New JerseyNew York-Presbyterian/Columbia, New York, New YorkStrong Memorial Hospital, Rochester, New YorkMontefiore Medical Center, Bronx, New YorkMount Sinai Medical Center, New York, New YorkWestchester Medical Center, Valhalla, New YorkCleveland Clinic Foundation, Cleveland, OhioNationwide Children’s Hospital, Columbus, OhioChildren’s Hospital Medical Center, Cincinnati, OhioOhio State University Medical Center, Columbus, OhioUniversity Hospital of Cleveland, Cleveland, OhioIntegris Baptist Medical Center, Oklahoma City, OklahomaProvidence Portland Medical Center, Portland, OregonOregon Health and Science University, Portland, OregonAllegheny General Hospital, Pittsburgh, PennsylvaniaChildren’s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh,Pennsylvania

Children’s Hospital of Philadelphia, Philadelphia, PennsylvaniaPenn State Milton S Hershey Medical Center, Hershey, Pennsylvania





Hahnemann University Hospital, Philadelphia, PennsylvaniaUniversity of Pittsburgh Medical Center, Pittsburgh, PennsylvaniaThomas Jefferson University Hospital, Philadelphia, PennsylvaniaTemple University Hospital, Philadelphia, PennsylvaniaThe Hospital of the University of PA, Philadelphia, PennsylvaniaCardiovascular Center of Puerto Rico, San Juan, Puerto RicoMedical University of South Carolina, Charleston, South CarolinaBaptist Memorial Hospital, Memphis, TennesseeSt. Thomas Hospital, Nashville, TennesseeVanderbilt University Medical Center, Nashville, TennesseeUniversity Hospital, San Antonio, TexasChildren’s Medical Center of Dallas, Dallas, TexasSeton Medical Center, Austin, TexasMedical City Dallas Hospital, Dallas, TexasSt Luke’s Episcopal Hospital, Houston, TexasMethodist Specialty and Transplant Hospital, San Antonio, TexasUniversity of Texas Medical Branch, Galveston, TexasThe Methodist Hospital, Houston, TexasUniversity Hospital—St. Paul, Dallas, TexasScott and White Memorial Hospital, Temple, TexasTexas Children’s Hospital, Houston, TexasBaylor University Medical Center, Dallas, TexasIntermountain Medical Center, Murray, UtahUniversity of Utah Health Sciences Center, Salt Lake City, UtahPrimary Children’s Medical Center, Salt Lake City, UtahInova Fairfax Hospital, Falls Church, VirginiaMCV Hospitals, Richmond, VirginiaMcGuire Virginia Medical Center, Richmond, VirginiaSentara Norfolk General Hospital, Norfolk, VirginiaUniversity of Virginia HSC, Charlottesville, VirginiaSeattle Children’s Hospital, Seattle, WashingtonSacred Heart Medical Center, Spokane, WashingtonUniversity of Washington Medical Center, Seattle, WashingtonChildren’s Hospital of Wisconsin, Milwaukee, WisconsinFroedtert Memorial Lutheran Hospital, Milwaukee, WisconsinAurora St. Luke’s Medical Center, Milwaukee, WisconsinUniversity of Wisconsin Hospital and Clinics, Madison, Wisconsin

A, adult; P, pediatric; ISO, International Organization for Standardization.aData provided via Australia and New Zealand Cardiothoracic Transplant Registry (ANZCOTR).bData provided via Eurotransplant (ET).cData provided via Scandiatransplant.dData provided via L’Agence de la Biomédicine.eData provided via United Kingdom Transplant Support Service Authority (UKTSSA).fLung data provided via Organización Nacional de Trasplantes (ONT).gHeart data provided directly to ISHLT Registry.hHeart data provided via Registro Español de Trasplante Cardíaco.iData provided via United Network for Organ Sharing (UNOS).




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25. International Society for Heart and Lung Transplantation. RegistriesSlides. http://www.ishlt.org/registries. Accessed August 1, 2013.




























































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