iv drug compatibility chart of selected meds.pdf

7/25/2019 IV Drug Compatibility Chart of selected meds.pdf

1/23

IV Drug Compatibility Chart

The IV drug compatibility chart is based on information from the Handbook of Injectable Drugs, 16th Edition, byLawrence A. Trissel, FASHP, copyright 2010, American Society of Health-System Pharmacists. Incompatibilitiesare based on meeting anyof the following criteria:

Additive Compatibility

Drugs in Syringe Compatibility

Y-Site Injection Compatibility (1:1 Mixture)

Additionally, in some cases one brand of product may be compatible but another brand of drug is not. When thisoccurred, incompatible was used.

Disclaimer:

This IV Drug Compatibility Chart is provided as a quick reference, however since information is subject to changeit is advised that you check with a pharmacist for recommendations as well as product information to check forany changes or additional incompatibilities.

Key:

= Compatible = Incompatible

= A drug intersects with itself

= The relationship was investigated and the results were equivocal.

= No data available


2/23

IV Drug Compatibility Chart A

AbataceptAbciximab

AcetylcysteineAcyclovir Sodium

AdenosineAldesleukin

Alfentanil hydrochlorideAllopurinol Sodium

Alteplase, RecombinantAmifostine

Amikacin SulfateAmiodarone Hydrochloride

Amphotericin B DesoxycholateAmphotericin B Lipid-Based

Ampicillin Sodium/Sulbactam Sodium

Ampicillin SodiumAntihemophilic Factor

ArgatrobanAsparaginase

Atracurium BesylateAtropine Sulfate

AzacitidineAzathioprineAzithromycin

Alteplase(Activase,rTPA

)

Amiodarone(Cordarone)

Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)

Dobutamine(Dobutrex)

Dopamine

Epinephrine(Adrenalin)

Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)

Lidocaine(Xylocaine)

Lorazepam(Ativan)

Magnesium

Sulfate

MetoprololTartrate(Lopressor)

MorphineSulfate

NorepinephrineBitartrate

Pantoprazole(Protonix)

Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate

Sodiumnitroprusside(Nip

ride)

Succinylcholine(Anectine)

Verapamil


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


MorphineSulfate

Norepinephrine


Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate


ride)


Verapamil


3/23

IV Drug Compatibility Chart A

B

BasaliximabBendamustine Hydrochloride

Benztropine MesylateBevacizumab

BivalirudenBleomycin Sulfate (BLM)

BortezomibBumetanide

Buprenorphine HydrochlorideBusulfan

Butorphanol Tartrate


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


MorphineSulfate



Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate


ride)


Verapamil


4/23

IV Drug Compatibility Chart C

C1 Inhibitor, HumanCabazitaxel

Calcium ChlorideCalcium Gluconate

CarboplatinCarmustine

Cefepime HydrochlorideCefotaxime Sodium

Cefoxitin SodiumCeftaroline Fosamil Monoacetate

CeftazidimeCeftizoxime SodiumCeftriaxone Sodium

Cefturoxime SodiumChloramphenicol Sodium Succinate

Chlorpromazine HydrochlorideCidofovir

CimetidineCiprofloxacin

Cisatracurium BesylateCisplatin

Clevidipine ButyrateClindamycin Phosphate

ClorfarabineCyclosporine

CytomegalovirusImmune Globulin Intravenous, Human


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


MorphineSulfate



Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate

Sodiumnitroprusside(Nipride)


Verapamil


5/23

IV Drug Compatibility Chart D

DacarbazineDaclizumabDaptomycin

Darbepoetin AlfaDaunorubicin Hydrochloride (DNR)

DecitabineDenileukin Diftitox

Desmopressin AcetateDexamethasone

Dexamethasone Sodium PhosphateDexmedetomidine Hydrochloride

DiazepamDigoxin

Diltiazem HydrochlorideDimenhydrinate

Diphenhydramine HydrochlorideDobutamine Hydrochloride

DocetaxelDopamine Hydrochloride

DoripenemDoxorubicin Hydrochloride, Conventional

Doxycycline HyclateDrotrecogin Alfa


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


MorphineSulfate



Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate



Verapamil


6/23

IV Drug Compatibility Chart E

EnalaprilatEnoxaparin Sodium

Epinephrine HydrochlorideEpirubicin Hydrochloride

Epoetin Alfa RecombinantEpoprostenol Sodium

EptifibatideEribulin Mesylate

Erythromycin LactobionateEsmolol HydrochlorideEsomeprazole SodiumEstrogens Conjugated

Ethacrynate SodiumEtoposide


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


MorphineSulfate



Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate



Verapamil


7/23

IV Drug Compatibility Chart F

Factor IX ConcentratesFamotidine

Fenoldopam MesylateFentanyl Citrate

FerumoxytolFibrinogen Concentrate (Human)

FilgrastimFluconazole

Fludarabine PhosphateFlumazenil

FluorouracilFolic Acid

Fosaprepitant DimeglumineFoscarnet Sodium

Fosphenytoin Sodium

Furosemide


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate

MetoprololTartrate(Lopr

essor)

MorphineSulfate



Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate



Verapamil


8/23

IV Drug Compatibility Chart G

Ganciclovir SodiumGemcitabine Hydrochloride

Gemtuzumab OzogamicinGentamicin Sulfate

Granisetron Hydrochloride


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


essor)

MorphineSulfate



Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate


Succinylcholine(Anectin

e)

Verapamil


9/23

IV Drug Compatibility Chart H

Heparin Sodium (lock flush solution)Hydrocortisone Sodium Succinate

Hydromorphone Hydrochloride


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


essor)

MorphineSulfate



Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate



e)

Verapamil


10/23

IV Drug Compatibility Chart I

Ibandronate SodiumIbritumomab tiuxetan

Ibuprofen LysineIbutilide Fumarate

Idarubicin HydrochlorideIfosfamide

Imipenem-Cilastatin SodiumImmune Globulin I.V.Inamrinone Lactate

Indomethacin Sodium TrihydrateInfliximab

Insulin Injection (regular insulin)Interferon Alfa-2b Recombinant

Interferon Gamma-1bIrinotecan Hydrochloride

Iron Dextran ParenteralIsoproterenol Hydrochloride

Ixabepilone


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


essor)

MorphineSulfate



Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate



e)

Verapamil


11/23

IV Drug Compatibility Chart K

Ketorolac Tromethamine


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


essor)

MorphineSulfate



Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate



e)

Verapamil


12/23

IV Drug Compatibility Chart L

Labetalol HydrochlorideLacosamide

LepirudinLeucovorin Calcium

LevetiracetamLevofloxacin

Levoleucovorin CalciumLevothyroxine Sodium

Lidocaine HydrochlorideLiothyronine Sodium

LorazepamLymphocyte Immune Globulin

Anti-Thymocyte Globulin Sterile Solution


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


essor)

MorphineSulfate



Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate



e)

Verapamil


13/23

IV Drug Compatibility Chart M

MannitolMechlorethamine Hydrochloride

Melphalan Hydrochloride

Meperidine HydrochlorideMesna

MethocarbamolMethotrexate, Methotrexate Sodium(Amethopterin, MTX)

Methoxy Polythylene Glycol-Epoetin BetaMethyldopate HCI

Methylergonovine MaleateMethylprednisolone

Metoclopramide HCIMetoprolol Tartrate

MetronidazoleMicafungin Sodium

Midazolam HydrochlorideMilrinone LacatateMinocycline Hydrochloride

MitomycinMitoxantrone Hydrochloride

Morphine SulfateMoxifloxacin Hydrochloride

Muromonab-CD3Mycophenolate Mofetil HCI


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


essor)

MorphineSulfate



Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate



e)

Verapamil


14/23

IV Drug Compatibility Chart N

Naloxone HydrochlorideNatalizumab

Nesiritide

Nicardipine HydrochlorideNitroglycerinIV

Nitroprusside SodiumNorepinephrine Bitartrate


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


essor)

MorphineSulfate



Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate



e)

Verapamil


15/23

IV Drug Compatibility Chart O

OfatumumabOndansetron Hydrochloride

Oxaliplatin

Oxytocin, Parenteral


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


MorphineSulfate



Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate

Sodiumnitroprusside(Ni

pride)


e)

Verapamil


16/23

IV Drug Compatibility Chart P

PaclitaxelPalifermin

Palonosetron Hydrochloride

Pamidronate DisodiumPancuronium Bromide

PanitumumabPantoprazole Sodium

PegaspargasePegloticasePemetrexed

Penicillin G Aqueous PotassiumPentamidine Isethionate

Phenobarbital SodiumPhenytoin Sodium

Phytonadione

Piperacillin Sodium/Tazobactam SodiumPolymyxin B SulfatePotassium Salts

PralatrexatePrednisolone

Procainamide HydrochlorideProchlorperazine

Promethazine HydrochloridePropranolol Hydrochloride

Protamine SulfatePyridoxine Hydrochloride


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


MorphineSulfate



Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate



e)

Verapamil


17/23

IV Drug Compatibility Chart Q

Quinidine Gluconate

Quinupristin/Dalfopristin


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


MorphineSulfate



Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate



e)

Verapamil


18/23

IV Drug Compatibility Chart R

Ranitidine HydrochlorideRasburicase

Remifentanil Hydrochloride

Reteplase RecombinantRifampin

RituximabRocuronium Bromide

Romidepsin


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


MorphineSulfate

NorepinephrineBitartrat

e


Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate



e)

Verapamil


19/23

IV Drug Compatibility Chart S

SargramostimScopolamine Hydrobromide

Sildenafil Citrate

Sodium BicarbonateSodium Chloride

Sotalol HydrochlorideStreptozocin

Succinylcholine Chloride


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


MorphineSulfate


e


Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate



e)

Verapamil


20/23

IV Drug Compatibility Chart T

TacrolimusTelavancin

Temozolomide

TemsirolimusTenecteplase

TeniposideTheophylline

ThiotepaTicarcillin Disodium and Clavulanate Potassium

TigecyclineTirofiban Hydrochloride

Tobramycin SulfateTocilizumab

Topotecan HydrochlorideTrastuzumab

Treprostinil SodiumTrimethroprim and SulfamethoxazoleTubocurarine Chloride


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


MorphineSulfate


e


Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate



e)

Verapamil


21/23

IV Drug Compatibility Chart V

Valproic AcidVancomycin Hydrochloride

Vasopressin

Vecuronium BromideVerapamil Hydrochloride

Vinblastine SulfateVincristine Sulfate

Vinorelbine TartrateVoriconazole


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


MorphineSulfate


e


Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate



e)

Verapamil


22/23

IV Drug Compatibility Chart W

Warfarin Sodium


)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


MorphineSulfate


e


Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate



e)

Verapamil


23/23

IV Drug Compatibility Chart Z

ZidovudineZoledronic Acid

Alteplase(Activase,rTPA)


Argatroban

Atropine

Calciumchloride

Diltiazem

(Cardizem)


Dopamine


Esmolol(Brevibloc)

Furosemide(Lasix)

Heparin

Insulin(regular)


Lorazepam(Ativan)

Magnesium

Sulfate


MorphineSulfate



Phenytoin(Dilantin)

Potassium

chloride

Propofol(Diprivan)

Sodiumbicarbonate



e)

Verapamil

iv drug compatibility chart of selected meds.pdf

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