IVÁN J, NÚÑEZ GIL, MD,. PhD. On behalf of CAAR investigators.

OBJETIVOS Y CRITERIOS DE IN/EXCLUSIÓN

• Registro internacional de aneurismas coronarios (dco angiográfico).

• Def: 1,5X el segmento de referencia.

• Excluye ectasias.

OBJETIVOS Y CRITERIOS DE IN/EXCLUSIÓN

• Cierre de reclutamiento (2018).

GRACIAS¡¡¡¡¡

CENTER CITY COUNTRY PATIENTS PERIOD OF TIME ASSESED ANGIOS REVIEWED INCIDENCE (%)

Hospital Clínico San Carlos/ Hospital Severo Ochoa/Hospital Príncipe de Asturias*

MADRID SPAIN 484 (487) Jan/2004-Dec/2015 51,914 0.93

Instituto de Cardiología y Cirugía Cardiovascular

LA HABANA CUBA 125 05/March/2005-15/Nov/2015 3,578 3.49

Hospital Juan Ramón Jiménez HUELVA SPAIN 77 Jan/2009-Dec/2015 12,600 0.61

Montefiore Medical Center NEW YORK UNITED STATES 75 2008 Jan- 2016 Oct 52,223 0.14

Hospital Clínico Universitario de Valladolid

VALLADOLID SPAIN 67 1/Dec/2007 – 31/Dec/2015 34,772 0.19

Hospital de Valdecilla SANTANDER SPAIN 65 1/Jul/2007- 30/Sept/ 2014 13,130 0.49

Hospital Central de Asturias OVIEDO SPAIN 64 Jan/2008-Dec/2015 26,089 0.24

Kerckhoff Heart and Thorax Center

BAD NAUHEIM GERMANY 57 Nov/2008-Sept/2015 41,543 0.13

Hospital Arnau de Vilanova LERIDA SPAIN 56 1/Jan/2012- 31/Dec/2015 4,208 1.33

Città della Salute e della Scienza, Molinnette 2

TURIN ITALY 53 Jan/2007-Dec/2015 10,234 0.51

Hospital de Clínicas Dr. Manuel Quintela

MONTEVIDEO URUGUAY 42 16/March/2006-31/Dec/2015 4,722 0.88

Ospedale Fatebenefratelli MILAN ITALY 36 08/Jan/2007 - 14/Jan/2016 9,131 0.39

Infermi Hospital, Rivoli. TURIN ITALY 36 10/Apr/2006- 22/Dec/2015 15,506 0.23

Hospital Álvaro Cunqueiro VIGO SPAIN 35 Apr/2006-Dec/2015 39,000 0.08

Azienda Ospedaliera Universitaria Policlinico"P.Giaccone"

PALERMO ITALY 33 Jun/2009 - Dec/2015. 6,724 0.49

Hospital La Sapienza ROMA ITALY 33 1/Jan/2011-31/Dec/2015 7,897 0.41Hospital de La Princesa MADRID SPAIN 30 Jan/2009-Dec/2013 8,087 0.37Hospital Lozano Blesa ZARAGOZA SPAIN 25 1/Jan/2009-31/Dec/2015 16,460 0.15Utrecht Medisch Centrum UTRECHT NETHERLANDS 25 01/Jan/2015- 31/Dec/2015 1,144 2.18

Hospital General Universitario de Albacete

ALBACETE SPAIN 23 Nov/2014 – Apr/2015 880 2.61

Hospital Central de la Defensa “Gomez Ulla”

MADRID SPAIN 23 1/Jan/2009-28/Apr/2016 1,279 1.79

Hospital Universitario de Canarias GRAN CANARIA SPAIN 21 Jan/2011-Dec/2015 6,993 0.30

Hospital de Bellvitge BARCELONA SPAIN 19 1/Jan/2011-21/Dec/2015 25,300 0.07

Bolognini Hospital Seriate BOLOGNINI ITALY 12 Nov/2006-Jan/2014 7,443 0.16Hospital de Cabueñes GIJON SPAIN 10 Jan/2011-Dec/2015 9,110 0.10Città della Salute e della Scienza, Molinnette 1

TURIN ITALY 8 Aug/2008 – Dec/2015 8,400 0.09

University Hospital, London Health Sciences Centre

LONDON, ONTARIO CANADA 6 Jan/2015-Dec/2016 4,394 0.13

Hospital San Giovanni Bosco TURIN ITALY 6 Jan/2013-Dec/2015 7,331 0.08

Istituto Clinico Sant'Ambrogio, Milan

MILAN ITALY 6 Jul/2013 – Aug/2016 5,022 0.11

Mayo Clinic PHOENIX, Arizona UNITED STATES 5 (6) 1/Jan/2015 - 22/March/2015 315 1.58

University Hospital Brno BRNO Czech Republic 4 1/Feb/16-30/Apr/16 1,038 0.38

TOTAL - - 1561(1565) Jan/2004-Dec/2016 436,467

0.35

SITUACIÓN ACTUAL

RESULTADOS

RESULTADOS Overall aneurysms cohort

(n=1565)Gender /male (%) 1229 (78.5%)Age (mean±SD) 65.5 ± 12.7Hypertension (%) 1131 (72.3%)Dyslipemia (%) 931 (59.3%)Diabetes Mellitus (%) 400 (25.5%)Smoking habit (%) 644 (41.2%)Renal failure /CrCl<30 (%) 128 (8.2%)Peripheral vascular disease (%) 173 (11.1%)Working diagnosis (%)

-Chest pain.

- Stable angina

- NSTEACS

- STEACS

-Ventricular tachycardia/fibrillation/sudden death

- Valvular study

- Presurgery (non cardiac)

- Syncope

175 (11.2%)

244 (15.6%)

645 (41.2%)

318 (20.3%)

13 (0.8%)

95 (6.1%)

14 (0.9%)

3 (0.2%)Coronary artery disease, number of vessels (%)

- 1

- 2

- 3

1.77±1.05

434 (27.7%)

394 (25.2%)

517 (33.0%)Left ventricular ejection fraction (mean±SD), % 54.8± 13.2 %

RESULTADOS

DEATH -MULTIVARIATE ANALYSIS (variables remaining in the equation)Variable Hazard Ratio Confidence interval, 95% pAge ≥ 70 years 2.77 2.05-3.76 0.000Caucasian race 1,85 1.14-2.99 0.012Hypertension 1.38 0.97-1.95 0.068Diabetes 1.27 0.96-1.68 0.088Renal failure (Cr CR<30) 1.77 1.23-2.54 0.002Peripheral vessel disease 1.91 1.38-2.63 0.000Severe stenosis (per vessel)

1.20 1.05-1.38 0.008

LV abnormal (<55%) 1.55 1.18-2.04 0.002Discharge anticoagulation 1.98 1.43-2.74 0.000Acute diagnosis+ 1.53 1.12-2.09 0.008

MACE- MULTIVARIATE ANALYSIS (variables remaining in the equation)Variable Hazard Ratio Confidence interval, 95% pAge ≥ 70 years 1.51 1.29-1.84 0.000Caucasian race 1,76 1.29-2.41 0.000Diabetes 1.43 1.18-1.75 0.000Renal failure (Cr CR<30) 1.52 1.15-2.02 0.003Peripheral vessel disease 1.45 1.13-1.80 0.004Severe stenosis (per vessel)

1.15 1.05-1.27 0.002

LV abnormal (<55%) 1.34 1.11-1.62 0.002Discharge anticoagulation 1.64 1.29-2.10 0.000Acute diagnosis+ 1.48 1.19-1.83 0.000