8/14/2019 Ix. Pathophysiology

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IX. PATHOPHYSIOLOGY

CHRONIC RENAL FAILURE

Non-modifiable Risk Factors:

AgeGender

Heredity

Modifiable Risk Factors:

DietSedentary Lifestyle

Nephrotoxins

Remaining nephrons must filter

more solute particles from the blood

Hypertrophy of remaining nephrons

As nephrons are destroyed, theremaining nephrons undergo change

to compensate for those that are los

Renal Failure

Further damage of nephrons

Nephrons cannot tolerate the work

Renal Blood

Renal Reserve

Damage to Nephrons

Renal Insufficiency

More than 75% damage

50% damage

Stage 1

Stage 2

Death

Impaired kidney function & Uremia

Reduction in renal capillariesScarring of GlomeruliAtrophy & Fibrosis of tubules

Kidne mass

> 90% kidney damage

Continuous decline in renal fxn.

End Stage Renal Dse.(ESRD)

Continuous MultisystemAffectation

Stage 4

80-90% damageStage 3