March 2017 CURRICULUM VITAE

Jack A. Taylor, M.D., Ph.D.

Education

1977 B.A. (Biology) cum laude, Carleton College Northfield, Minnesota 1978-80 Ph.D. Candidate, Population Genetics and Evolutionary Biology University of Arizona, Tucson, Arizona 1984 M.D. University of Wisconsin School of Medicine Madison, Wisconsin 1993 Ph.D. Epidemiology, University of North Carolina, Chapel Hill, North

Carolina Board Certification National Board of Medical Examiners #292343 Medical license, North Carolina #30868 American Board of Preventive Medicine: Specialist in Public Health and General Preventive Medicine Brief Chronology of Employment 1976 Environmental Biologist, Water Treatment Plant, Ward Paper Company 1977-78 Water Quality Researcher, Wisconsin Department of Natural Resources 1978-80 Graduate Teaching Assistant, University of Arizona 1984-85 Resident, Department of Radiology, Michigan State University 1985-87 Resident, Preventive Medicine, University of North Carolina 1985-88 USPHS-NIH Epidemiology Training Program, NIEHS 1988-95 Senior Clinical Researcher, Epidemiology Branch, NIEHS 1995-date Tenure Appointment, Senior Investigator, Epidemiology Branch, NIEHS 1997-date Head, Molecular & Genetic Epidemiology Section, Laboratory Molecular Carcinogenesis, now Epigenetics & Stem Cell Biology Laboratory, NIEHS University Affiliations Adjunct Professor, Department of Epidemiology, University of North Carolina Adjunct Member, Lineberger Comprehensive Cancer Center, University of North Carolina Adjunct Professor, Department of Medicine, Duke University Honors & Other Special Scientific Activities Summer Research Fellowship, University of Wisconsin School of Medicine, 1981 Dean's Award for Academic Achievement, U Wisconsin Medical School, 1982 and 1983 Fellow, Conte Institute for Environmental Health NCI Ad Hoc Study Section on Genetic Alterations in Bladder Carcinogenesis, 1988 NRC Committee on DoE Radiation Epidemiological Research Program, 1992 - 1994

Reviewer for: British J. Cancer Cancer Research Carcinogenesis Environmental Research Environmental and Molecular Mutagenesis International J. Cancer Journal of the National Cancer Institute Molecular Carcinogenesis Molecular Medicine Obstetrics and Gynecology Oncogene Pharmacogenetics National Toxicology Program Chemical Nominations Committee NCI ad hoc committee on molecular-epidemiologic enhancements to the NCI Prostate, Lung, Colorectal (PLCO) Screening Trial. NIEHS Interdisciplinary Research Awards 1993-94: Genetic susceptibility to spontaneous abortion 1994-95: Genetic and environmental risk factors for myelodysplasia 1994-95: Reproductive failure associated with mutation of the ER gene

1998-01: Functional analysis of human DNA metabolic genes and clinically important mutant alleles in bacteria & yeast

U.S. Public Health Service Commendation Medal 1994: “For development of a highly creative program of epidemiologic research that incorporates molecular genetic markers in studies of environmental causes of human disease.” NIEHS Institutional Review Board 1995-2003 Acting Clinical Director, NIEHS 12/95-2/96 NCI Committee on Promotions, ad hoc member, 1997 Acting Chair, NIEHS Institutional Review Board 8/98-11/98 NIEHS Executive Committee, 1997-2001 NIH Merit Award 1997: “For development of the Environmental Genome Project” NIH Central Tenure Committee, Ad hoc member 1997-2003 Vice Chair, NIEHS Institutional Review Board 1998-2003 Chair, NIEHS Environmental Genomics Faculty 1999 – 2003 NIEHS Merit Award for contributions to the NIEHS Strategic Plan 2005 Working Group Co-Chair Trans-NIH Research Initiative 2006 Editorial Review Board Environmental Health Perspectives NIEHS Committee on Tenure and Promotions 2002-2007 NIEHS Annual Directors Allocation for Research Excellence (A-DARE) Award 2007 Associate Editor: Cancer Epidemiology, Biomarkers, and Prevention 1998-2009 NIH Central Tenure Committee permanent member 2003-2007, ad hoc 2008, 2009

NIEHS Microarray Core Facility Advisory Committee 2006-2011 Advisory Board for Oxidative Stress Director’s Challenge Project, Chair NIEHS Molecular Genetics Core Facility Advisory Committee Editorial Board: Journal of Cancer Epidemiology Senior Editorial Board: International Journal of Molecular Epidemiology & Genetics

Chair, Biostatistics Search Committee 2014 NIEHS Next Generation Sequencing Advisory Committee, 2009 - 2015

Current Committees and Journal Board Activities

Board of Governors, NIH Center for Inherited Disease Research, 1997-present American Cancer Society Biospecimen Advisory Board, 2002-present Sister Study Steering Committee, 2004-present NIEHS Clinical Advisory Committee, 2008-present NIEHS IT Management Committee, 2015 – present National Toxicology Program Scientific Director Search Committee 2016-2017 NIEHS Committee on Promotions III 2017 – present NIH Central Tenure Committee ad hoc reviewer 2017 Funded Grants Examination of genetic alterations in preneoplastic and neoplastic lesions of the lung from

uranium miners. Consultant. DOE. St. Mary’s Hosptial and Medical Center, Dr. Marshall Anderson PI, $506,393 1994-1997

Breast Cancer SPORE. Consultant, Molecular Epidemiology Program. P50CA58223-03 University of North Carolina, Dr. Edison Liu PI, $1,500,000 per year, 1992-1995 Environmentally induced bladder cancer: a genetic study. Consultant. IR01ES06094 Salk

Institute, Dr. S. Sukumar PI, $50,000 per year, 1992-1994 Nutritional biochemistry and epidemiology of cancer training grant. T32CA72319-01A1

Consultant. University of North Carolina, Dr. Lenore Kohlmeier PI, $88,856, 1997-2002, renewal $1.4M, 2002-2007

Environmental Health and Susceptibility Center Grant. U. North Carolina, Affiliate Member,

Genetic Susceptibility Core, $700,000 per year, 2001-2004 Department of Energy Prostate Cancer Consortium. PI Genetic Susceptibility Project, and

Co-investigator Proteomics Project. Dr. James Mohler Consortium PI $9,997,794, 2003-2008

Susan G Komen for the Cure. The Two Sister Study (Co-Investigator). CR Weinberg PI, $1,750,000, 2008-2010

Publications 1 Rosenzweig MD and Taylor JA. Speciation and diversity in Ordovician invertebrates: filling

niches quickly and carefully. Oikos 35:236-243, 1980. 2 Taylor JA and Davis JP. Evidence for clustering of amyotrophic lateral sclerosis in Wisconsin.

J Clin Epidemiol 1989; 42:569-575. 3 Taylor JA. Oncogenes and their application in epidemiologic studies. Am J Epidemiol 1989;

130:6-13.

4. Taylor JA. Epidemiologic Studies of the Molecular Genetics of Cancer. Birth Defects 1989; 25:83-93. 5 Sienko DG, Davis JP, Taylor JA, Brooks BR. Amyotrophic lateral sclerosis: A case-control

study of a cluster in a small Wisconsin Community. Arch Neurol 1990; 47:38-41. 6 Taylor JA. Epidemiologic Evidence of Genetic Susceptibility to Cancer. Birth Defects 1990;

26:113-127. 7 Liu YH, Taylor JA, Linko P, Lucier GW, and Thompson CL. Glutathione S-transferase in

Human Lymphocyte and Liver: Role in Modulating Formation of Carcinogen-Derived DNA Adducts. Carcinogenesis 1991; 12:2269-2275.

8 Taylor JA, Li Y, You M, Wilcox AJ, Liu E. B region variant of the estrogen receptor gene.

Nucleic Acids Res 1992; 20:2895. 9 Bell DA, Thompson CL, Taylor JA, et al. Genetic monitoring of human polymorphic cancer

susceptibility genes by polymerase chain reaction: application to glutathione transferase . Environ Health Perspect 1992; 98:113-117.

10 Taylor JA, Sandler DP, Bloomfield CD, et al. ras oncogene activation and occupational

exposures in acute myeloid Leukemia. J Natl Cancer Inst 1992; 84:1626-1632. PMID: 1433344

11 Piegorsch W, Taylor JA. Statistical methods for assessing environmental effects on human

genetic disorders. Environmetrics 1992; 3:369-384. 12 Bell DB, Taylor JA, Paulson DF, Robertson JL, Mohler JL, Lucier GW. Genetic risk and

carcinogen exposure: A common inherited defect of the carcinogen-metabolism gene Glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J Natl Cancer Inst 1993; 85:1159-1164.

13 Taylor JA, Wilcox AJ, Bowes WA, Li Y, Liu ET, You M. Risk of miscarriage and a common

variant of the estrogen receptor gene. Am J Epidemiol 1993; 137:1361-1364. 14 Taylor JA, Bell DA, Nagorney D. L-myc proto-oncogene alleles and susceptibility to

hepatocellular carcinoma. Int J Cancer 1993; 54:927-930. 15 Bell DB, Taylor JA, Butler MA, Stephens E, Wiest J, Brubaker LH, Kadlubar FF, Lucier GW.

Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans. Carcinogenesis 1993; 14:1689-1692.

16 Schweikl H, Taylor JA, Kitereewan S, Linko P, Nagorney D, Goldstein JA. Expression of

CYP1A1 and CYP 1A2 genes in human liver. Pharmacogenetics 1993; 3:239-249. 17 Piegorsch W, Weinberg CR, Taylor JA. Non-hierarchical logistic models and case-only

designs for assessing susceptibility in population-based case-control studies. Stat Med 1994; 13:153-162.

18 Taylor JA, Watson MA, Devereux TR, Michels R, Saccomanno G, Anderson M. P53 mutation

hotspot in radon-associated lung cancer. Lancet 1994; 343:86-87.

19 Stephens EA, Taylor JA, Kaplan N, Hsieh, LL, Lucier GW, Bell DA. Ethnic variation in the

CYP2E1 gene: Polymorphism analysis of 685 African-Americans, European-Americans and Taiwanese indicates the presence of a unique haplotype in Taiwanese. Pharmacogenetics 1994; 4:185-192.

20 Packenham JP, Taylor JA, White CW, Anna CH, Barrett JC, Devereux TR. Homozygous

deletions at chromosome 9p21 and mutation analysis of p16 and p15 in microdissected primary non small cell lung cancers. Clinical Cancer Res 1995; 1:687-690.

21 Lancaster JM, Brownlee HA, Wiseman RW, Taylor JA. P53 polymorphism in ovarian and

bladder cancer. Lancet (letter) 1995; 346:182. 22 McDonald JW, Taylor JA, Watson MA, Saccomanno G, Devereux TR. p53 and K-ras in radon-associated lung adenocarcinoma. Cancer Epidemiol Biomarkers Prev 1995; 4:791- 793. 23 Packenham JP, Taylor JA, Anna CH, White CM, Devereux TR. Homozygous deletions but

not sequence mutations in coding regions of p15 or p16 in human primary bladder tumors Mol Carcinogenesis 1995; 14:147-151.

24 Hirvonen A, Taylor JA, Wilcox AJ, Berkowitz G, Schachter B, Chaparro C, Bell DA. Xenobiotic

metabolism genes and the risk of recurrent miscarriage. Epidemiology 1996; 7:206-208 25 Devereux TR, Taylor JA, Barrett JC. Molecular mechanisms of lung cancer: Interaction of

environmental and genetic factors. Chest 1996; 109:14S-19S. 26 Taylor JA, Li Y, Mason T, Mettlin C, Vogler WJ, Maygarden S, Liu E. p53 mutations in bladder

tumors from arylamine-exposed workers. Cancer Res 1996; 55:294-298 27 Chen H, Sandler D, Taylor JA, Watson M, Shore DL, Liu E, Bell DA. Increased risk for

myelodysplastic syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect. Lancet 1996; 347:295-297. PMID: 8569364

28 Lancaster JM, Brownlee HA, Bell DA, Berchuck A, Wiseman RW, Taylor JA,. Microsomal

epoxide hydrolase polymorphism as a risk factor for ovarian cancer. Mol Carcinogenesis 1996; 17:160-162.

29 Taylor JA, Hirvonen A, Watson, M, Pittman G, Mohler JL, Bell DA. Association of prostate

cancer with vitamin D receptor gene polymorphism. Cancer Res 1996; 56:4108-4110 30 Tomatis L, Huff J, Hertz-Picciotto I, Sandler D, Bucher J, Boffetta P, Axelson O, Blair A, Taylor

J, Stayner L, Barrett JC. Avoided and avoidable risks of cancer. Carcinogenesis 1997; 18:97-105.

31 Bell DA, Taylor JA. Genetic analysis of complex diseases. Science [Technical Comments]

1997; 275:1327-1328. 32 London SJ, Lehman TA, Taylor JA. Myeloperoxidase genetic polymorphism and lung cancer

risk. Cancer Res 1997; 57:5001-5003.

33 Taylor JA, Umbach DM, Stephens E, Castranio T, Paulson D, Robertson C, Mohler J, Bell DA. The role of N-acetylation polymorphisms in smoking-associated bladder cancer, evidence of a gene-gene-environment 3-way interaction. Cancer Res 1998; 58:3603-3610.

34 Lancaster, J. M., Berchuck, A., Carney, M. E., Wiseman, R., and Taylor JA, Progesterone

receptor gene polymorphism and risk for breast and ovarian cancer. Br J Cancer 1998; 78: 277.

35 Slebos RJC, Resnick MA, Taylor JA. Inactivation of the p53 tumor suppressor gene via a novel

Alu rearrangement. Cancer Res 1998; 58:5333-5336. 36 Hulla, JE, Miller, MS, Taylor JA, Hein DW, Furlong, CE, Omiecinski, CJ, and Kunkel, TA.

Symposium Overview, The Role of Genetic Polymorphism and Repair Deficiencies in Environmental Disease. Toxicol Sci 1999; 47:135-143.

37 Wilcox AJ, Taylor JA ,Sharp RR, London SJ,. Genetic determinism and over-protection of

human subjects. Nature Genetics 1999; 21: 36 38 Burroughs KD, Dunn SE, Barrett JC, Taylor JA. IGF-I: A key regulator of human cancer risk?

[invited editorial] J Natl Cancer Inst 1999; 91:579-81 39 Lunn RM, Bell DA, Mohler JL, Taylor JA. Prostate cancer risk and polymorphism in 17

hydroxylase (CYP17) and steroid reductase (SRD5A2). Carcinogenesis 1999; 20:1727-1731. 40 Blazer DG, Umbach DM, Bostick RM, Taylor JA. Vitamin D receptor polymorphisms and

prostate cancer. Mol Carcinogenesis 2000; 27:18-23. 41 Slebos RJC, Hoppin JA, Tolbert PE, Holly EA, Brock J, Zhang RH, Bracci PM, Foley J, Stockton

P, McGregor LM, Flake G, Taylor JA. K-ras and p53 in pancreatic cancer: Association with medical history, histopathology and environmental exposures in a population-based study. Cancer Epidemiol Biomarkers Prev 2000; 9:1223-1232.

42. Stern MC, Umbach DM, van Gils CH, Lunn RM, Taylor JA. DNA repair gene XRCC1

polymorphisms, smoking, and bladder cancer risk. Cancer Epidemiol Biomarkers Prev 2001; 10:125-131.

43 Stern, MC, Umbach DM, Yu MC, London SJ, Zhang Z-Q, Taylor JA. Hepatitis B, Aflatoxin B1,

and p53 codon p53 codon 249 mutation hepatocellular carcinomas from Guangxi, People’s Republic of China. Cancer Epidemiol Biomarkers Prev 2001; 10:617-627.

44 Slebos RJC, Taylor, JA. A novel host cell reactivation assay to assess homologous

recombination capacity in human cancer cell lines. Biochem Biophys Res Commun 2001; 281:212-219.

45 Devereux TR, Stern MC, Flake GP, Yu MC, London SJ, Taylor JA CTNNB1 mutations and

β-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1. Mol Carcinogenesis 2001; 31:68-73.

46 Hoppin JA, Tolbert PE, Taylor JA, Schroeder JC, Holly EA. Potential for selection bias with

tumor tissue retrieval for molecular epidemiology studies. Ann Epidemiol 2002; 12:1-6.

47 Stern MC, Johnson LR, Bell DA, Taylor JA. XPD codon 751 polymorphism, metabolism genes, smoking, and bladder cancer risk. Cancer Epidemiol Biomarkers Prev 2002; 11:1004-1011.

48 Thompson TE, Rogan PK, Risinger JI, Taylor JA. Splice variants, but not mutations, of DNA

Polymerase β are common in bladder cancer. Cancer Res 2002; 62:3251-3256. 49 vanGils CH, Conway K, Li Y, Taylor JA. HRAS1 variable number tandem repeat

polymorphism and risk of bladder cancer. Int J Cancer 2002; 100:414-418. 50 vanGils CH, Bostick RM, Stern MC, Taylor JA. Differences in base excision repair capacity

may modulate the effect of dietary antioxidant intake on prostate cancer risk: an example of polymorphisms in the XRCC1 gene. Cancer Epidemiol Biomarkers Prev 2002; 11:1279-1284.

51 Stern MC, Umbach DM, Lunn RM, Taylor JA. DNA repair gene XRCC3 codon 241

polymorphism, its interaction with smoking and XRCC1 polymorphisms and bladder cancer risk. Cancer Epidemiol Biomarkers Prev 2002; 11:939-943.

52 Slebos JC, Oh DS, Umbach DM, Taylor JA. Mutations in tetranucleotide repeats following

DNA damage depend on repeat sequence and carcinogenic agent. Cancer Res 2002; 62:6052-6060.

53 Engel LS, Taioli E, Pfeiffer R, Garcia-Closas M, Marcus PM, Lan Q, Boffetta P, Vineis P,

Autrup H, Bell DA, Branch RA, Brockmoller J, Kaly AK, Heckbert SR, Kalina I, Kang DH, Katoh T, Lafuente A, Lin HJU, Romkes M, Taylor JA, Rothman N. Pooled analysis and meta-analysis of GSTM1 and bladder cancer: A HuGE Mini-Review. Am J Epidemiol 2002; 156:95-109.

54 Jugessur A, Lie RT, Wilcox AJ, Murray JC, Taylor JA, Saugstad OD, Vindenes H, Abyholm F.

Variants of developmental genes (TGFα, TGFβ3, and MSX1) and their associations with facial clefts – A case-parent triad analysis. Genetic Epidemiol 2003; 24:230-239.

55 Jugessur A, Wilcox AJ, Lie RT, Murray JC, Taylor JA, Ulvik A, Vindenes H, Abyholm F.

Exploring the effects of methylenetetrahydrofolate reductase gene variants C677T and A1298C on the risk of orofacial clefts in 261 Norwegian case-parent triads. Am J Epidemiol 2003; 157:1083-1091.

56 Dunson DB, Watson M, Taylor JA. Bayesian latent variable models for median regression

on multiple outcomes. Biometrics 2003; 59:296-304 57 Jin YH, Clark AB, Slebos RJC, Al-Refai H, Taylor JA, Kunkel TA, Resnick MA, Gordenin

DA. Cadmium is a mutagen that acts by inhibiting mismatch repair. Nature Genetics 2003; 34:329-329.

4 58 Kamel F, Umbach DM, Lehman TA, Park LP, Munsat TL, Shefner JM, Sandler DP, Hu

H, Taylor JA. Amyotrophic Lateral Sclerosis, Lead, and Genetic Susceptibility: Polymorphisms in the δ-Aminolevulinic Acid Dehydratase and Vitamin D Receptor Genes. Environ Health Perspect 2003; 111:1335-1339. PMID: 12896855. PMC1241615

59 Jugessur A, Lie RT, Wilcox AJ, Murray JC, Taylor JA, Saugstad OD, Vindenes HA, Abyholm FE Cleft Palate, Transforming Growth Factor Alpha Gene Variants, and Maternal Exposures: Assessing Gene-Environment Interactions in Case-Parent Triads. Genetic Epidemiol 2003; 25:367-374.

60 Cooper GS, Treadwell EL, Dooley MA, St. Clair EW, Gilkeson GS, Taylor JA. N-Acetyl

Transferase Genotypes in Relation to Risk of Developing Systemic Lupus Erythematosus. J Rheum 2004; 31:76-80.

61 Schroeder JC, Conway K, Li Y, Mistry K, Bell DA, Taylor JA. P53 mutations in bladder

cancer: evidence for exogenous versus endogenous risk factors. Cancer Res 2003 63:7530-7358.

62 Slebos RJC, Umbach DM, Sommer CA, Horner GA, Choi JY, Taylor JA Analytical and

statistical methods to evaluate microsatellite allelic imbalance in small amounts of DNA. Lab Invest 2004; 84:648-657.

63 Li L, Umbach DM, Terry P, Taylor JA. Application of the GA/KNN method to SELDI

proteomics data. Bioinformatics 2004; 20:1638-1640. 64 Slebos RJC, Little RE, Umbach DM, Antipkin Y, Zadaorozhnaja TD, Mendel NA, Sommer

CA, Conway K, Parrish E, Gulino S, Taylor JA. Mini- and microsatellite mutations in children from Chernobyl accident cleanup works. Mut Res 2004; 559:143-51.

65 Terry PD, Kamel F, Umbach DM, Lehman TA, Hu H, Sandler DP, Taylor JA VEGF promoter

haplotype and amyotrophic lateral sclerosis (ALS) J Neurogenetics 2004; 18:429-434. PMID: 15763997

66 Terry PD, Umbach DM, Taylor JA. No association between SOD2 or NQO1 genotypes

and risk of bladder cancer. Cancer Epidemiol Biomarkers Prev 2005; 14:753-754. 67 Slebos RJC, Livanos E, Yim H-W, Randell SH, Parsons AM, Detterbeck FC, Rivera MP,

Taylor JA. Chromosomal abnormalities in bronchial epithelium from smokers, non-smokers and lung cancer patients. Cancer Genet Cytogenet 2005; 159:137-142.

68 Kamel F, Umbach DM, Hu H, Munsat TL, Shefner JM, Taylor JA, Sandler DP. Lead

exposure as a risk factor for amyotrophic lateral sclerosis. Neurodegener Dis 2005; 2:195-201.

69 Dunson DB, Taylor JA. Approximate Bayesian Inference for Quantiles. J Nonparametr Stat

2005; 17:385-400. 70 Taylor JA, Xu ZL, Kaplan NL, Morris RW. How well do HapMap haplotypes identify

common haplotypes of genes? A comparison with haplotypes of 334 genes resequenced in the Environmental Genome Project. Cancer Epidemiol Biomarkers Prev 2006; 15:133-137.

71 Terry PD, Umbach DM, Taylor JA. APE1 genotype and risk of bladder cancer: Evidence

for effect modification by smoking. Int J Cancer 2006; 31:516-518. 72 Stern MC, Conway K, Li Y, Mistry K, Taylor JA. DNA repair gene polymorphisms and

probability of p53 mutation in bladder cancer. Mol Carcinog 2006; 45:715-719.

73 Goodman M, Bostick RM, Ward KC, Terry PD, VanGils CH, Taylor JA, Mandel JS. Lycopene

intake and prostate cancer risk: effect modification by plasma antioxidants and XRCC1 genotype. Nutr Cancer 2006; 55:13-20.

74 Yim HW, Slebos RJC, Randell SH, Umbach DM, Parsons AM, Rivera MP, Detterbeck

FC, Taylor JA. Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cells. Cancer Lett 2007; 248:24-33. PMID

16517060 75 Flake GP, Rivera MP, Funkhouser WK, Slebos RJC, Maygarden SJ, Meadows KL, Long

EH, Stockton PS, Jones TC, Taylor JA. Detection of pre-invasive lung cancer: Technical aspects of the LIFE Project. Toxicol Pathol 2007; 35:65-74. PMID 17325974

76 King, AA, Shaughnessy DT, Mure K, Leszczynska J, Ward WO, Umbach DM, Xu Z, Ducharme

D, Taylor JA, DeMarini DM, Klein CB. Antimutagenicity of cinnamaldehyde and vanillin in human cells: Global gene expression and possible role of DNA damage and repair. Mutat Res 2007; 616:60-69. PMID: 17178418; PMC1955325

77 Gooden KM, Schroeder JC, North KE, Gammon MD, Hartmann KE, Taylor JA, Baird DD.

Val153Met polymorphism of catechol-o-methyltransferase and prevalence of uterine leiomyomata. Reprod Sci 2007; 14:117-120. PMID: 17636223

78 Wilcox AJ, Lie RT, Solvoll K, Taylor JA, McConnaughey DR, Abyholm F, Vindenes H, Vollset

SE, Drevon CA. Folic acid supplements and the risk of facial clefts: A national population-based case-control study. BMJ 2007; 334:464-469. PMID: 17259187; PMC1808175

79 Xu Z, Kaplan NL, Taylor JA. Tag SNP selection for candidate gene association studies

using HapMap and gene resequencing data. Eur J Hum Genetics 2007; 115:902-908. PMID: 17568388

80 Boyles AL, Wilcox AJ, Taylor JA, Meyer K, Fredriksen A., Ueland PM, Drevon CA, Vollset

SE, Lie RT. Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts. Am J Med Genetics 2008; 146A:440-449. PMID: 18203168; PMC2366099

81 Xu Z, Kaplan NL, Taylor JA. TAGster: Efficient selection of LD tag SNPs in single or multiple

populations. Bioinformatics 2008; 23:3254-3255. PMID: 17827206; PMC2782964 82 Lie RT, Wilcox AJ, Taylor JA, Gjessing HK, Saugstad OD, Aabyholm F, Vindenes HA.

Material smoking and oral clefts, the role of detoxification genes. Epidemiology 2008; 19:606-615. PMID: 18449058

83 Horton JK, Watson M, Stefanick DF, Shaughnessy DT, Taylor JA, Wilson SH. XRCC1 and

DNA polymerase beta in cellular protection against cytotoxic DNA single strand breaks. Cell Res. 2008; 18:48-63. PMID: 18166976; PMC2366203

84 Markunas CA, Umbach DM, Xu Z, Taylor JA Assessing candidate gene nsSNPs for

phenotypic differences in double-strand break repair using radiation-induced gamma H2A.X foci. J. Cancer Epidemiol 2008; 2008:387423.Epub 2009 Mar 12. PMID: 20445776; PMC2858903

83 Rodriguez A, Dunson DB, Taylor, JA. Bayesian hierarchically weighted finite mixture models

for samples of distributions. Biostatistics 2009; 10:155-171. doi: 10.1093/biostatistics/kxn024. Epub 2008 Aug 16. PMID: 18708650; PMC2733158

84 Boyles AL, Wilcox AJ, Taylor JA, Shi M, Weinberg, CR, Meyer K, Fredriksen A, Ueland PM, Johansen AM, Drevon CA, Jugessur A, Trung TN, Gjessing HK, Vollset SE, Murray JC, Christensen K, Lie RT. Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study. Genet Epidemiol 2009; 33:247-255. PMID: 19048631; PMC2677659

85 Kim S, Parks CG, DeRoo LA, Chen H, Taylor JA, Cawthon RM, Sandler DP. Obesity and

Weight Gain in Adulthood and Telomere Length. Cancer Epidemiol Biomarkers Prev 2009; 18:816-820. PMID: 19273484; PMC2805851

88 Xu Z, Taylor JA SNPinfo: Integrating GWAS and candidate gene information in functional

SNP selection for genetic association studies. Nucleic Acids Res 2009; 37(Web Server issue):W600-5. doi: 10.1093/nar/gkp290. Epub 2009 May 5. PMID: 19417063; PMC2703930

89 Stern MC, Lin J, Figueroa JD, Kelsey KT, Kiltie AE, Yuan JM, Matullo G, Fletcher T, Benhamou

S, Taylor JA, Placidi D, Zhang ZF, Steineck G, Rothman N, Kogevinas M, Silverman D, Malats N, Chanock S, Wu X, Karagas MR, Andrew AS, Nelson HH, Bishop DT, Sak SC, Choudhury A, Barrett JH, Elliot F, Corral R, Joshi A, Gago-Dominguez M, Cortessi VK, Xiang YB, Vineis P, Sacerdote C, Guarrera S, Polidoro S, Allione A, Gurzau E, Koppova K, Kumar R, Rudnai P, Porru S, Carta A, Campagna M, Arici C, Park SSL, Garcia-Closas M. Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the International Consortium of Bladder Cancer. Cancer Res 2009; 69: 6857-6864. doi: 10.1158/0008-5472.CAN-09-1091. Epub 2009 Aug 25. PMID: 19706757; PMC2782435

90 Boyles AL, DeRoo LA, Lie RT, Taylor JA, Jugessur A, Murray JC, Wilcox AJ. Maternal

alcohol consumption, alcohol metabolism genes and the risk of oral clefts: a population-based case-control study in Norway, 1996-2001. Am J Epidemiol 2010 15:172:924-931. doi: 10.1093/aje/kwq226. Epub 2010 Sep 1. PMID: 20810466; PMC2984244

91 Rothman N, Garcia-Closas M, Chatterjee N, Malats N, Wu X, Figueroa J, Cortessis V,

Matullo G, Baris D, Thun M, Kiemeney LA, Vineis P, De Vivo I, Real FX, Albanes D, Purdue M, Rafnar T, Hildebrandt M, Kiltie AE, Cussenot O, Golka K, Kumar R, Taylor JA, Mayordomo JI, Jacobs K, Hutchinson A, Wang Z, Fu Y-P, Prokunina-Olsson L, Burdette A, Yeager M. Wheeler W, Kogevinas M, Johson A. Schwenn M. Karagas M, Andriole G, Grubb R, Black A, Jacobs EJ, Diver RW, Gapstur SM, Weinstein S, Virtamo J, Van Den Berg D, Stern M, Yuan W, Gago M, Hunter D, McGrath M, Dinney C, Czerniak B, Chen M, Vermeulen SH, Aben KK, Witjes JA, Makkinje RR, Sulem P, Besenbacher S, Stefansson K, Riboli E, Brennan P, Panico S, Vararro C, Allen NE, Bueno-de-Mesquita HB, Trichopoulos D, Landi MT, Canzian F, Ljungberg B, Tjonneland A, Clavel-Chapelon F, Bishop DT, Teo MTW, Knowles MA, Guarrera S, Polidoro S, Ricceri F, Sacerdote C, Allione A, Cancel-Tassin G, Selinski S, Hengstler JG, Dietrich H, Fletcher T, Rudnai P, Gurzau E, Koppova K, Bolick S, Godfrey A, Xu Z, Sanz-Velez JI, Garcia-Prats MD, Sanchez M, Valdivia G, Caporaso N, Porru S, Benhamou S, Silverman DT, Chanock S. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nature Genet 2010: 42:978-984. doi: 10.1038/ng.687. Epub 2010 Oct 24. PMID: 20972438; PMC3049891

92 Xu X, Bensen JT, Smith GL, Mohler JL, Taylor JA. GWAS SNP replication among African

Americans and European Americans in the North Carolina-Louisiana Prostate Cancer Project (PcaP). Prostate 2011 71:881-891. Epub 2010 Nov 17. PMID: 21086507

93 Meadows KL, Andrews DMK, Xu Z, Laughlin SK, Baird DD, Taylor JA. Genome-wide

analysis of loss of heterozygosity and copy number amplification in uterine leiomyomas using the 100K single nucleotide polymorphism array. Exp Mol Pathol 2011; 91:434-439. PMID: 21497600

94 Shaughnessy DT, Gangarosa LM, Schliebe B, Umbach DM, Xu Z, MacIntosh B, Knize MG,

Mathews PP, Swank AE, Sandler RS, DeMarini DM, Taylor JA. Inhibition of fried meat-induced rectal DNA damage and altered systemic genotoxicity in humans by crucifera, chlorophyllin, and yogurt. PLoS One 2011; 6:e18707 PMID: 21541030; PMC3081825

95 Kim S, Sandler DP, Carswell G, DeRoo LA, Parks CG, Cawthon R, Weinberg CR, Taylor

JA. Telomere length in peripheral blood and breast cancer risk in a prospective case-cohort analysis: results from the Sister Study. Cancer Causes Control 2011; 22:1061-1066. PMID: 21643930; PMC3445257

96 Kim S, Sandler DP, Carswell G, Weinberg CR, Taylor JA. Reliability and Short-term Intra-

individual Variability of Telomere Length Measurement Using Monochrome Multiplexing Quantitative PCR. PLoS ONE 2011; 6: e27774. PMID: 21984947; PMC3184167

97 Fang F, Umbach DM, Xu Z, Ye W, Sandler DP, Taylor JA, Kamel F. No association between

DNA repair gene XRCC1 polymorphisms and risk of amyotrophic lateral sclerosis. Neurobiol Aging 2012; 33:1015.e25-6. doi: 10.1016/j.neurobiolaging.2010.07.004. Epub 2010 Aug 16. PMID: 20719408; PMC3005140

98 Sucheston LE, Bensen JT, Xu Z, Singh PK, Preus L, Mohler JL, Su LJ, Fontham ET, Ruiz B,

Smith GJ, Taylor JA. Genetic ancestry, self-reported race and ethnicity in African Americans and European Americans in the PCaP Cohort. PLoS ONE 2012; 7:e30950. PMID: 22479307; PMC3313995

99 Bensen JT, Xu Z, Smith GJ, Mohler JL, Fontham ET, Taylor JA. Genetic polymorphism

and prostate cancer aggressiveness: A case-only study of 1536 GWAS and candidate SNPs in African Americans and European Americans. Prostate 2013; 73:11-22. doi: 10.1002/pros.22532. Epub 2012 May 1. PMID: 22549899; PMC3480543

100 Kim S, Parks CG, Xu Z, DeRoo LA, Sandler DP, Taylor JA. Association between genetic

variants in DNA and histone methylation and telomere length. PLoS ONE 2012; 7:e40504. Epub 2012 Jul 11. PMID: 22792358; PMC3394714

101 Taioli E, Sears V, Watson A, Flores-Obando RE, Jackson MD, Ukoli FA, de Syllos Cólus IM,

Fernandez P, McFarlane-Anderson N, Ostrander EA, Rodrigues IS, Stanford JL, Taylor JA, Tulloch-Reid M, Ragin CC. Polymorphisms in CYP17 and CYP3A4 and prostate cancer in men of African descent. Prostate. 2012 Nov 5. doi: 10.1002/pros.22612. [Epub ahead of print] PMID: 23129512

102 Xu Z, Bolick SC, Deroo LA, Weinberg CR, Sandler DP, Taylor JA. Epigenome-wide association study of breast cancer using prospectively collected Sister Study samples. J Natl Cancer Inst 2013 May 15;105(10):694-700. Epub 2013 Apr 11. PMID:23578854

103 White AJ, Sandler DP, Bolick SCE, Xu Z, Taylor JA, DeRoo LA. Recreational and

household physical activity at different time points and DNA global methylation. Eur J Cancer 2013; pii: S0959-8049(13)00121-4. doi: 10.1016/j.ejca.2013.02.013. Epub 2013 Mar 6. PMID: 23473616

104 Kim S, Taylor JA, Milne GL, Sandler DP. Association between urinary prostaglandin E2

metabolite and breast cancer risk: a prospective, case-cohort study of postmenopausal women. Cancer Prev Res (Phila). 2013 Jun;6(6):511-8. doi: 10.1158/1940-6207.CAPR-13-0040. Epub 2013 May 1. PMID: 23636050

105 Godfrey AC, Xu, Z, Weinberg CR, Getts RC, Wade PA, DeRoo LA, Sandler DP, Taylor JA.

Serum microRNA expression as an early marker for breast cancer risk in prospectively collected samples from the Sister Study Cohort. Breast Cancer Res. 2013 May 24;15(3):R42. [Epub ahead of print] PMID: 23705859

106 Bensen JT, Xu Z, McKeique PM, Smith GL, Mohler JL, Taylor JA. Admixture mapping of

prostate cancer in African Americans participating in the North Carolina-Louisiana Prostate Cancer Project (PCaP). Prostate. 2014 Jan;74(1):1-9. doi: 10.1002/pros.22722. Epub 2013 Sep 4. PMID: 24037755

107 Deroo LA, Bolick SC, Xu Z, Umbach DM, Shore D, Weinberg CR, Sandler DP, Taylor JA.

Global DNA methylation and one-carbon metabolism gene polymorphisms and the risk of breast cancer in the Sister Study. Carcinogenesis. 2014 Feb;35(2):333-338 Epub 2013 Oct 15. PMID: 24130171

108 Xu Z, Taylor JA. Genome-wide age-related DNA methylation changes in blood and other

tissues relate to histone modification, expression, and cancer. Carcinogenesis. 2014 Feb;35(2):356-364 Epub 2013 Nov 28. PMID: 24287154107

109 Kessler DC, Taylor JA, Dunson DB. Learning phenotype densities conditional on many interacting predictors. Bioinformatics Epub 2014 Feb 17 PMID 24501099.

110 Weinberg CR, Shi M, Deroo LA, Taylor JA, Sandler DP, Umbach DM. Asymmetry in family

history implicates nonstandard genetic mechanisms: application to the genetics of breast cancer. PLoS Genet. 2014 Mar 20;10(3):e1004174. doi:10.1371/journal.pgen. 1004174. PMID: 24651610 PCID: 3961172.

111 Cooke, SL, Shlien A, Marshall J, Pipinikas CP, Martincorena I, Tubio JMC, Li, Y, Menzies A,

Mudie L, Ramakrishna M, Yates L, Davies H, Bolli N, Bignell GR, Tarpey PS, Behjati S, Nik-Zainal S, Papaemmanuil E, Teixeira VH, Raine K, O’Meara S, Dodoran MS, Teague JW, Butler AP, Iacobuzio-Donahue C, Santarius T, Grundy R, Malkin D, Greaves M, Munshi N, Flanagan AM, Bowtell D, ICGC Breast Cancer Group, Martin S, Larsimont D, Reis-Filho JS, Boussioutas A, Taylor JA, Hayes N, Janes SM, Futreal A, Stratton MR, McDermott UA, Campbell PJ. Processed pseudogenes acquired somatically during cancer development. 2014 Nature Communications 5:3644 DOI: 10.1038/ncomms4644 PMID: 24714652 PMCID: PMC3996531 .

112 Harlid SS, Xu Z, Panduri V, Sandler DP, Taylor JA. CpG Sites Associated with Cigarette Smoking: Analysis of Epigenome-Wide Data from the Sister Study. Environ Health Perspect; Epub 2014 Apr 4 DOI:10.1289/ehp.1307480. PMID: 24704585 PMCID: PMC4080519

113 Markunas CA, Xu Z, Harlid SS, Wade PA, Lie RT, Taylor JA, Wilcox AJ. Identification of

DNA methylation changes in newborns related to maternal smoking during pregnancy. Environ Health Perspect 2014 122:1147–1153; http://dx.doi.org/10.1289/ehp.1307892 PMID: 24906187 PMCID: PMC4181928

114 Ju YS, Alexandrov LB, Gerstung M, Martincorena I, Nik-Zainal S, Ramakrishna M, Davies

HR, Papaemmanuil E, Gundem G, Shlien A, Bolli N, Behjati S, Tarpey PS, Nangalia J, Massie CE, Butler AP, Teague JW, Vassiliou GS, Green AR, Du MQ, Unnikrishnan A, Pimanda JE, Teh BT, Munshi N, Greaves M, Vyas P, El-Naggar AK, Santarius T, Collins VP, Grundy R, Taylor JA, Hayes DN, Malkin D; ICGC Breast Cancer Group; ICGC Chronic Myeloid Disorders Group; ICGC Prostate Cancer Group, Foster CS, Warren AY, Whitaker HC, Brewer D, Eeles R, Cooper C, Neal D, Visakorpi T, Isaacs WB, Bova GS, Flanagan AM, Futreal PA, Lynch AG, Chinnery PF, McDermott U, Stratton MR, Campbell PJ. Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer. Elife. 2014 Oct 1;3. doi: 10.7554/eLife.02935. PMID: 25271376

115 Harlid SS, Xu Z, Panduri V, D’Aloisio AA, DeRoo LA, Sandler DP, Taylor JA. In utero

exposure to diethylstilbestrol and blood DNA methylation in women ages 40-59 years from the Sister Study. PLoS One. 2015 Mar 9;10(3): e0118757. doi: 10.1371/journal.pone. 0118757. PMID: 25751399 PMC4353728

116 Helfand BT, Roehl KA, Cooper PR, McGuire B, Fitzgerald LM, Cancel-Tassin G, Cornu JN,

Bauer S, Van Blarigan EL, Chen X, Duggan D, Ostrander EA, Gwo-Shu M, Zhang ZF, Chang SC, Jeong S, Berndt S, McDonnell SK, Kittles R, Rybicki BA, Freedman M, Kantoff P, Pomerantz M, Breyer JP, Smith JR, Rebbeck TR, Mercola D, Isaacs WB, Wiklund F, Cussenot O, Thibodeau SJ, Schaid DJ, Cannon-Albright L, Cooney KA, Chanock SJ, Stanford JL, Chan JM, Witte J, Xu J, Bensen JT, Taylor JA, Catalona WJ. Associations of prostate cancer risk variants with disease aggressiveness: Results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases. Hum Genet. 2015 Apr;134(4):439-50. doi: 10.1007/s00439-015-1534-9. PMID: 25715684.

117 Hair BY, Kirk E, Harlid S, Sandhu R, Robinson WR, Wu MC, Olshan AF, Conway K, Taylor

JA, Troester MA. Body mass index associated with genome-wide methylation in breast tissue. Breast Cancer Res Treat. 2015 Jun;151(2):453-63. doi: 10.1007/s10549-015-3401-8. PMID: 25953686.

118 Xu Z, Niu L, Li L, Taylor JA. Enmix: a novel background correction method for Illumina

HumanMethylation450 BeadChip. Nucleic Acids Res. 2016 Feb 18;44(3):e20. doi: 10.1093/nar/gkv907. Epub 2015 Sep 17. PubMed PMID: 26384415.

119 Wilson LE, Kim S, Xu Z, Harlid S, Sandler DP, Taylor JA. Non-steroidal anti-inflammatory

drug use and genomic DNA methylation in blood. PLoS One. 2015 Sep 22;10(9):e0138920. doi: 10.1371/journal.pone.0138920. eCollection 2015. PMID: 26393518.

120 Kim S, Shore DL, Wilson LE, Sanniez EI, Kim JH, Taylor JA, Sandler DP. Lifetime use of

nonsteroidal anti-inflammatory drugs and breast cancer risk: results from a prospective study

of women with a sister with breast cancer. BMC Cancer. 2015 Dec 16;15(1):960. doi: 10.1186/s12885-015-1979-1. PMID: 26673874.

121 Figueroa JD, Middlebrooks CD, Banday AR, Ye Y, Garcia-Closas M, Chatterjee N, Koutros

S, Kiemeney LA, Rafnar T, Bishop T, Barnes HF, Matullo G, Golka K, Gago-Dominguez M, Taylor JA, Fletcher T, Siddiq A, Cortessis VK, Kooperberg C, Cussenot O, Benhamou S, Prescott J, Porru S, Dinney CP, Malats N, Baris D, Purdue MP, Jacobs EJ, Albanes D, Wang Z, Chung CC, Vermeulen SH, Aben KK, Galesloot TE, Thorleifsson G, Sulem P, Stefansson K, Kiltie AE, Harland M, Teo M, Offit K, Vijai J, Bajorin D, Kopp R, Fiorito G, Guarrera S, Scaredote C, Selinski S, Hengstler JG, Gerullis H, Ovsianikov D, Blaszkewicz M, Castelao JE, Calaza M, Martinez ME, Cordeiro P, Xu Z, Panduri V, Kumar R, Gurzau E, Koppova K, Bueno-de-Mesquita HB, Ljungberg B, Clavel-Chapelon F, Weiderpass E, Krogh V, Dorronsoro M, Travis RC, Tjønneland A, Brennan P, Chang-Claude J, Riboli E, Conti D, Stern MC, Pike MC, Van Den Berg D, Yuan JM, Hohensee C, Rodabough R, Cancel-Tassin G, Roupret M, Comperat E, Chen C, De Vivo I, Giovannucci E, Hunter DJ, Kraft P, Lindstrom S, Carta A, Pavanello S, Arici C, Mastrangelo G, Kamat AM, Zhang L, Gong Y, Pu X, Hutchinson A, Burdett L, Wheeler WA, Karagas MR, Johnson A, Schned A, Hosain GM, Schwenn M, Kogevinas M, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Andriole G Jr, Grubb R 3rd, Black A, Diver WR, Gapstur SM, Weinstein S, Virtamo J, Haiman CA, Landi MT, Caporaso NE, Fraumeni JF Jr, Vineis P, Wu X, Chanock SJ, Silverman DT, Prokunina-Olsson L, Rothman N. Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry. Hum Mol Genet. 2016 Jan 4. pii: ddv492. [Epub ahead of print] PubMed PMID: 26732427..

122 O'Brien KM, Shi M, Sandler DP, Taylor JA, Zaykin DV, Keller J, Wise AS, Weinberg CR. A

family-based, genome-wide association study of young-onset breast cancer: inherited variants and maternally mediated effects. Eur J Hum Genet. 2016 Feb 17. doi: 10.1038/ejhg.2016.11. [Epub ahead of print] PubMed PMID: 26883092.

123 Joubert BR, Felix JF, Yousefi P, Bakulski KM, Just AC, Breton C, Reese SE, Markunas CA, Richmond RC, Xu CJ, Küpers LK, Oh SS, Hoyo C, Gruzieva O, Söderhäll C, Salas LA, Baïz N, Zhang H, Lepeule J, Ruiz C, Ligthart S, Wang T, Taylor JA, Duijts L, Sharp GC, Jankipersadsing SA, Nilsen RM, Vaez A, Fallin MD, Hu D, Litonjua AA, Fuemmeler BF, Huen K, Kere J, Kull I, Munthe-Kaas MC, Gehring U, Bustamante M, Saurel-Coubizolles MJ, Quraishi BM, Ren J, Tost J, Gonzalez JR, Peters MJ, Håberg SE, Xu Z, van Meurs JB, Gaunt TR, Kerkhof M, Corpeleijn E, Feinberg AP, Eng C, Baccarelli AA, Benjamin Neelon SE, Bradman A, Merid SK, Bergström A, Herceg Z, Hernandez-Vargas H, Brunekreef B, Pinart M, Heude B, Ewart S, Yao J, Lemonnier N, Franco OH, Wu MC, Hofman A, McArdle W, Van der Vlies P, Falahi F, Gillman MW, Barcellos LF, Kumar A, Wickman M, Guerra S, Charles MA, Holloway J, Auffray C, Tiemeier HW, Smith GD, Postma D, Hivert MF, Eskenazi B, Vrijheid M, Arshad H, Antó JM, Dehghan A, Karmaus W, Annesi-Maesano I, Sunyer J, Ghantous A, Pershagen G, Holland N, Murphy SK, DeMeo DL, Burchard EG, Ladd-Acosta C, Snieder H, Nystad W, Koppelman GH, Relton CL, Jaddoe VW, Wilcox A, Melén E, London SJ. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. Epub 2016 Mar 31. PubMed PMID: 27040690; PubMed Central PMCID: PMC4833289.

124 Wilson LE*, D'Aloisio AA, Sandler DP, Taylor JA. Long-term use of calcium channel blocking

drugs and breast cancer risk in a prospective cohort of US and Puerto Rican women. Breast

Cancer Res. 2016 Jul 5;18(1):61. doi: 10.1186/s13058-016-0720-6. PubMed PMID: 27378129; PubMed Central PMCID: PMC4932734.

125 Goossens ME, Isa F, Brinkman M, Mak D, Reulen R, Wesselius A, Benhamou S, Bosetti C, Bueno-de-Mesquita B, Carta A, Allam MF, Golka K, Grant EJ, Jiang X, Johnson KC, Karagas MR, Kellen E, La Vecchia C, Lu CM, Marshall J, Moysich K, Pohlabeln H, Porru S, Steineck G, Stern MC, Tang L, Taylor JA, van den Brandt P, Villeneuve PJ, Wakai K, Weiderpass E, White E, Wolk A, Zhang ZF, Buntinx F, Zeegers MP. International pooled study on diet and bladder cancer: the bladder cancer, epidemiology and nutritional determinants (BLEND) study: design and baseline characteristics. Arch Public Health. 2016 Jul 6;74:30. doi: 10.1186/s13690-016-0140-1. PubMed PMID: 27386115; PubMed Central PMCID: PMC4933992.

126 Markunas CA†, Wilcox AJ, Xu Z*, Joubert BR, Harlid S*, Panduri V‡, Håberg SE, Nystad W, London SJ, Sandler DP, Lie RT, Wade PA, Taylor JA. Maternal Age at Delivery Is Associated with an Epigenetic Signature in Both Newborns and Adults. PLoS One. 2016 Jul 6;11(7):e0156361. doi: 10.1371/journal.pone.0156361. PubMed PMID: 27383059; PubMed Central PMCID: PMC4934688.

127 O'Brien KM, Shi M, Sandler DP, Taylor JA, Zaykin DV, Keller J, Wise AS, Weinberg CR. A family-based, genome-wide association study of young-onset breast cancer: inherited variants and maternally mediated effects. Eur J Hum Genet. 2016 Aug;24(9):1316-23. doi: 10.1038/ejhg.2016.11. PubMed PMID: 26883092; PubMed Central PMCID: PMC4989201.

128 Permuth JB, Pirie A, Ann Chen Y, Lin HY, Reid BM, Chen Z, Monteiro A, Dennis J, Mendoza-Fandino G; AOCS Study Group.; Australian Cancer Study (Ovarian Cancer)., Anton-Culver H, Bandera EV, Bisogna M, Brinton L, Brooks-Wilson A, Carney ME, Chenevix-Trench G, Cook LS, Cramer DW, Cunningham JM, Cybulski C, D'Aloisio AA, Anne Doherty J, Earp M, Edwards RP, Fridley BL, Gayther SA, Gentry-Maharaj A, Goodman MT, Gronwald J, Hogdall E, Iversen ES, Jakubowska A, Jensen A, Karlan BY, Kelemen LE, Kjaer SK, Kraft P, Le ND, Levine DA, Lissowska J, Lubinski J, Matsuo K, Menon U, Modugno R, Moysich KB, Nakanishi T, Ness RB, Olson S, Orlow I, Pearce CL, Pejovic T, Poole EM, Ramus SJ, Anne Rossing M, Sandler DP, Shu XO, Song H, Taylor JA, Teo SH, Terry KL, Thompson PJ, Tworoger SS, Webb PM, Wentzensen N, Wilkens LR, Winham S, Woo YL, Wu AH, Yang H, Zheng W, Ziogas A, Phelan CM, Schildkraut JM, Berchuck A, Goode EL, Pharoah PD, Sellers TA; Ovarian Cancer Association Consortium.. Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk. Hum Mol Genet. 2016 Aug 15;25(16):3600-3612. doi: 10.1093/hmg/ddw196. PubMed PMID: 27378695; PubMed Central PMCID: PMC5179948.

129 Harlid S*, Adgent M, Jefferson WN, Panduri V‡, Umbach DM, Xu Z*, Stallings VA, Williams CJ, Rogan WJ, Taylor JA. Soy Formula and Epigenetic Modifications: Analysis of Vaginal Epithelial Cells from Infant Girls in the IFED Study. Environ Health Perspect. 2016 Aug 19. [Epub ahead of print] PubMed PMID: 27539829.

130 Niu L§, Xu Z*§, Taylor JA. RCP: a novel probe design bias correction method for Illumina Methylation BeadChip. Bioinformatics. 2016 Sep 1;32(17):2659-63. doi: 10.1093/bioinformatics/btw285. PubMed PMID: 27153672; PubMed Central PMCID: PMC5013906.

131 Saini N, Roberts SA, Klimczak LJ, Chan K, Grimm SA, Dai S, Fargo DC, Boyer JC, Kaufmann WK, Taylor JA, Lee E, Cortes-Ciriano I, Park PJ, Schurman SH, Malc EP, Mieczkowski PA,

Gordenin DA. The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts. PLoS Genet. 2016 Oct 27;12(10):e1006385. doi: 10.1371/journal.pgen.1006385. PubMed PMID: 27788131; PubMed Central PMCID: PMC5082821.

132 Kim S†, Campbell J, Yoo W, Taylor JA, Sandler DP. Systemic levels of estrogens and PGE2 synthesis in relation to postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2016 Nov 18. pii: cebp.0556.2016. [Epub ahead of print] PubMed PMID: 27864342.

133 Xu Z*, Taylor JA, Leung YK, Ho SM, Niu L. oxBS-MLE: an efficient method to estimate 5-methylcytosine and 5-hydroxymethylcytosine in paired bisulfite and oxidative bisulfite treated DNA. Bioinformatics. 2016 Dec 1;32(23):3667-3669. PubMed PMID: 27522082; PubMed Central PMCID: PMC5181539.

134 Amos CI, Dennis J, Wang Z, Byun J, Schumacher FR, Gayther SA, Casey G, Hunter DJ, Sellers TA, Gruber SB, Dunning AM, Michailidou K, Fachal L, Doheny K, Spurdle AB, Li Y, Xiao X, Romm J, Pugh E, Coetzee GA, Hazelett DJ, Bojesen SE, Caga-Anan C, Haiman CA, Kamal A, Luccarini C, Tessier D, Vincent D, Bacot F, Van Den Berg DJ, Nelson S, Demetriades S, Goldgar DE, Couch FJ, Forman JL, Giles GG, Conti DV, Bickeböller H, Risch A, Waldenberger M, Brüske-Hohlfeld I, Hicks BD, Ling H, McGuffog L, Lee A, Kuchenbaecker K, Soucy P, Manz J, Cunningham JM, Butterbach K, Kote-Jarai Z, Kraft P, FitzGerald L, Lindström S, Adams M, McKay JD, Phelan CM, Benlloch S, Kelemen LE, Brennan P, Riggan M, O'Mara TA, Shen H, Shi Y, Thompson DJ, Goodman MT, Nielsen SF, Berchuck A, Laboissiere S, Schmit SL, Shelford T, Edlund CK, Taylor JA, Field JK, Park SK, Offit K, Thomassen M, Schmutzler R, Ottini L, Hung RJ, Marchini J, Amin Al Olama A, Peters U, Eeles RA, Seldin MF, Gillanders E, Seminara D, Antoniou AC, Pharoah PD, Chenevix-Trench G, Chanock SJ, Simard J, Easton DF. The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers. Cancer Epidemiol Biomarkers Prev. 2017 Jan;26(1):126-135. doi: 10.1158/1055-9965.EPI-16-0106. PubMed PMID: 27697780; PubMed Central PMCID: PMC5224974.

135 Wilson LE*, Harlid S*, Xu Z*, Sandler DP, Taylor JA. An epigenome-wide study of body mass index and DNA methylation in blood using participants from the Sister Study cohort. Int J Obes (Lond). 2017 Jan;41(1):194-199. doi: 10.1038/ijo.2016.184. PubMed PMID: 27773939; PubMed Central PMCID: PMC5209267.

136 Shi M, O'Brien KM, Sandler DP, Taylor JA, Zaykin DV, Weinberg CR. Previous GWAS hits in relation to young-onset breast cancer. Breast Cancer Res Treat. 2017 Jan;161(2):333-344. doi: 10.1007/s10549-016-4053-z. PubMed PMID: 27848153; PubMed Central PMCID: PMC5226879.

137 Xu Z*, Langie SA, De Boever P, Taylor JA, Niu L. RELIC: a novel dye-bias correction method for Illumina Methylation BeadChip. BMC Genomics. 2017 Jan 3;18(1):4. doi: 10.1186/s12864-016-3426-3. PubMed PMID: 28049437; PubMed Central PMCID: PMC5209853.

138 O’Brien KM, Sandler DP, Taylor JA, Weinberg CR. Serum vitamin D and risk of breast cancer within five years. In Press, Environ Health Perspect.

139 Milne RL, Kuchenbaecker KB, Michailidou K, [numerous contributing authors including Taylor JA], Bader GD, Pharoah PDP, Couch FJ, Easton DF, Kraft P, Chenevix-Trench G,

Garcia-Closas M, Schmidt MK, Antoniou AC, Simard J. Identification of ten variants associated with risk of estrogen receptor negative breast cancer. In Press Nature Genetics.

140 Phelan CM, Kuchenbaecker KB, Tyrer JP, Kar SP, Lawrenson K, Winham SJ, [numerous contributing authors including Taylor JA], Chenevix-Trench G, Goode EL, Sellers TA, Gayther SA, Antoniou AC, Pharoah PDP. Identification of twelve novel susceptibility loci for different histotypes of epithelial 1 ovarian cancer. In Press, Nature Genetics.

Book Chapters 1 Zhang, Z-F, Cordon-Cardo C, Rothman N, Taylor JA. Methodological issues in the use of

tumor markers in cancer epidemiology. In: Application of Biomarkers in Cancer Epidemiology, Toniolo, Boffetta et al eds, 1997, IARC, Lyon.

2 Stern MC, Koper NP, Taylor JA. Molecular Epidemiology. In: Introduction to Biochemical

Toxicology. Hodgson and Smart (eds) 2000. Letters 1. Taylor JA. Cone loss of the week. Science 1990; 247:270-271.

2. Taylor JA, Sandler DP, Shore DL. Re: Acute Myelogenous Leukemia. JNCI 1993; 85:921.

3. Taylor JA, Anderson M. Re: p53 mutation hotspot in radon-associated lung cancer. Lancet

1994; 343:1158-1159.

4. Taylor JA, Wilcox AJ. Re: Risk of miscarriage and a common variant of the estrogen receptor gene. Am. J. Epidemiol. 1994; 140:1145 Conference Chair or Organizer American Association for Cancer Research Program Committee 1997, 2000, 2001 Conference Co-Chairman, NIH Symposium on Environmental Genome Project, Oct 1997 Co-organizer EPA/NIEHS Workshop on Applying Biomarker Research, Chapel Hill NC, Aug 1999 Co-organizer NIEHS Conference on Epidemiology in the 21st Century, Chapel Hill NC Nov 1999 Co-organizer UNC/NIEHS Conference on Epidemiology of DNA Repair, Chapel Hill, Mar 2001 AACR Annual Meeting, Organizer and Chair, Special Forum on Proteomics, 2004 Invited Talks (selected, since 1994) American Association for Cancer Research and Environmental Mutagen Society special conference: "Risk Assessment in Environmental Carcinogenesis" Whistler, Canada 1994. Karolinska Institute, conference: "Molecular Mechanisms of Environmental Mutagenesis and Carcinogenesis" Huddinge, Sweden 1994. Mayo Clinic Comprehensive Cancer Center, Rochester MN 1994 University of Minnesota Cancer Center, Minneapolis MN 1994 International Society for Environmental Epidemiology Annual Meeting, Symposium: "Genetic

susceptibility to environmental hazards," Research Triangle Park, NC 1994. Agency for Toxic Substances and Disease Registry workshop: "The role of biomarkers in field studies of environmentally associated cancers" Atlanta, GA 1994. American Association for Cancer Research Annual Meeting, Symposium: “Mechanistic basis of ethnic differences in cancer risk” Toronto, Ontario, Canada 1995 International Society for Environmental Epidemiology Conference: “Host Factors in Environmental Epidemiology”. Keynote Address. Cracow, Poland 1995 Karolinska Institute Symposium “Molecular mechanisms of environmental mutagenesis and carcinogenesis” Stockholm, Sweden, Sep 1996 Fred Hutchinson Cancer Research Center and National Cancer Institute Workshop on Diet/Nutrition and Genetic Susceptibility in Relation to Cancer. Washington DC Jan 1997 MD Anderson Cancer Center, Grand Rounds, Houston TX, Jan 1997 University of California, San Francisco Symposium: “Molecular Advances in Cancer Epidemiology and Prevention. San Francisco CA Feb 1997 NIH Director’s Seminar Series, Bethesda, MD Mar 1997 Society of Toxicology Annual Meeting, Seattle WA, Mar 1998 Environmental Mutagen Society Annual Meeting, Plenary Address (Alexander Hollaender Lecture) Anaheim CA, Mar 1998 University of Cincinnati, Center for Environmental Genetics Apr 1998 Centers for Disease Control, Conference on Genetics and Public Health, Atlanta GA, May 1998 American College of Epidemiology Workshop on Genetic Fundamentals of Molecular Epidemiology, Chicago IL June 1998; San Francisco CA Sep 1998 12th International Conference on Carcinogenesis and Risk Assessment. Austin TX, Dec 1998 American Cancer Society 2nd Annual Schilling Conference. Santa Cruz CA, Mar 1999 Society of Toxicology, Chicago IL, May 1999 VII CEPH Annual Conference on Human Genetics; Paris France, May 1999 American College of Epidemiology Workshops, Baltimore MD June 1999; & Washington DC Oct 1999 NIOSH Workshop on Genetic Susceptibility, Morgantown WV Mar 2000 American College of Epidemiology Workshops, Seattle June 2000; Atlanta GA Sep 2000 Norway National Institute of Public Health Conference on Merging Genetics and Epidemiology, Keynote address, Oslo Norway, Aug 2000 American College of Epidemiology Workshops, Toronto Canada, Jun 2001 Congress of Epidemiology, Toronto Canada, Jun 2001 US-European Workshop on Gene-Environment Research at the Interface of Toxicology and Epidemiology, Garmisch, Germany Sep 2001 Brown University, Biomedical Center, Providence RI, Nov 2001 Centers for Disease Control, Atlanta GA, Feb 2002 American College of Epidemiology Workshops, Albuquerque Sep 2002 DNA Repair Interest Group National Videoconference, Jan 2003 American College of Epidemiology Workshop, Atlanta GA, Jun 2003 Environmental Protection Agency, Research Triangle Park NC Sep 2003 Centers for Disease Control, Atlanta GA, Sep 2003 Carleton College, Northfield MN, Feb 2004 American Association for Cancer Research Annual Meeting, Orlando FL Mar 2004 Jackson Laboratory Meeting: “Assessing Human Germ Cell Mutagenesis” Bar Harbor ME Sep 2004 University of North Carolina Center for Environmental Health and Susceptibility, Chapel Hill NC Feb 2005 American Association for Cancer Research Annual Meeting, Anaheim CA, Apr 2005 Society for Epidemiologic Research Annual Meeting, Toronto, Canada Jun 2005

University of Wisconsin, UW Population Health Institute, Madison WI, Mar 2008 Congress of the Netherlands Epidemiological Society (plenary address), Jun 2008 Cedars-Sinai Comprehensive Cancer Institute, Los Angles CA, Sep 2010 Global Alliance to Prevent Prematurity and Stillbirth. Seattle WA Oct 2010 American Cancer Society, Atlanta GA, Mar 2011 NC State, Dept Environmental and Molecular Toxicology, Raleigh NC Apr 2011 St. Olaf College, Northfield MN Mar 2013 Karmanos Cancer Institute, Detroit MI Mar 2013 Duke University, Durham NC, June 2013 IARC, Lyon France, June 2016

Publications since last review 1 White AJ‡, Sandler DP, Bolick SC*, Xu Z*, Taylor JA, DeRoo LA. Recreational and household

physical activity at different time points and DNA global methylation. Eur J Cancer. 2013 Jun;49(9):2199-206. doi: 10.1016/j.ejca.2013.02.013. PubMed PMID: 23473616; PubMed Central PMCID: PMC3686968.

2 Godfrey AC*, Xu Z*, Weinberg CR, Getts RC, Wade PA, DeRoo LA, Sandler DP, Taylor JA. Serum microRNA expression as an early marker for breast cancer risk in prospectively collected samples from the Sister Study cohort. Breast Cancer Res. 2013 May 24;15(3):R42. doi: 10.1186/bcr3428. PubMed PMID: 23705859; PubMed Central PMCID: PMC3706791.

3 Kim S†, Taylor JA, Milne GL, Sandler DP. Association between urinary prostaglandin E2 metabolite and breast cancer risk: a prospective, case-cohort study of postmenopausal women. Cancer Prev Res (Phila). 2013 Jun;6(6):511-8. doi: 10.1158/1940-6207.CAPR-13-0040. PubMed PMID: 23636050; PubMed Central PMCID: PMC3677792.

4 Bensen JT§, Xu Z§*, McKeigue PM, Smith GJ, Fontham ET, Mohler JL, Taylor JA. Admixture mapping of prostate cancer in African Americans participating in the North Carolina-Louisiana Prostate Cancer Project (PCaP). Prostate. 2014 Jan;74(1):1-9. doi: 10.1002/pros.22722. PubMed PMID: 24037755; PubMed Central PMCID: PMC3934014.

5 Deroo LA§, Bolick SC§*, Xu Z*, Umbach DM, Shore D, Weinberg CR, Sandler DP, Taylor JA. Global DNA methylation and one-carbon metabolism gene polymorphisms and the risk of breast cancer in the Sister Study. Carcinogenesis. 2014 Feb;35(2):333-8. doi: 10.1093/carcin/bgt342. PubMed PMID: 24130171; PubMed Central PMCID: PMC3908748.

6 Xu Z*, Taylor JA. Genome-wide age-related DNA methylation changes in blood and other tissues relate to histone modification, expression and cancer. Carcinogenesis. 2014 Feb;35(2):356-64. doi: 10.1093/carcin/bgt391. PubMed PMID: 24287154; PubMed Central PMCID: PMC3908753.

7 Weinberg CR, Shi M, DeRoo LA, Taylor JA, Sandler DP, Umbach DM. Asymmetry in family history implicates nonstandard genetic mechanisms: application to the genetics of breast cancer. PLoS Genet. 2014 Mar 20;10(3):e1004174. doi: 10.1371/journal.pgen.1004174. PubMed PMID: 24651610; PubMed Central PMCID: PMC3961172.

8 Cooke SL, Shlien A, Marshall J, Pipinikas CP, Martincorena I, Tubio JM, Li Y, Menzies A, Mudie L, Ramakrishna M, Yates L, Davies H, Bolli N, Bignell GR, Tarpey PS, Behjati S, Nik-Zainal S, Papaemmanuil E, Teixeira VH, Raine K, O'Meara S, Dodoran MS, Teague JW, Butler AP, Iacobuzio-Donahue C, Santarius T, Grundy RG, Malkin D, Greaves M, Munshi N, Flanagan AM, Bowtell D, Martin S, Larsimont D, Reis-Filho JS, Boussioutas A, Taylor JA, Hayes ND, Janes SM, Futreal PA, Stratton MR, McDermott U, Campbell PJ; ICGC Breast Cancer Group.. Processed pseudogenes acquired somatically during cancer development. Nat Commun. 2014 Apr 9;5:3644. doi: 10.1038/ncomms4644. PubMed PMID: 24714652; PubMed Central PMCID: PMC3996531.

9 Kessler DC, Taylor JA, Dunson DB. Learning phenotype densities conditional on many interacting predictors. Bioinformatics. 2014 Jun 1;30(11):1562-8. doi: 10.1093/bioinformatics/btu040. PubMed PMID: 24501099; PubMed Central PMCID: PMC4029029.

10 Harlid S*, Xu Z*, Panduri V‡, Sandler DP, Taylor JA. CpG sites associated with cigarette smoking: analysis of epigenome-wide data from the Sister Study. Environ Health Perspect. 2014 Jul;122(7):673-8. doi: 10.1289/ehp.1307480. PubMed PMID: 24704585; PubMed Central PMCID: PMC4080519.

11 Markunas CA§†, Xu Z§*, Harlid S*, Wade PA, Lie RT, Taylor JA, Wilcox AJ. Identification of DNA methylation changes in newborns related to maternal smoking during pregnancy. Environ Health Perspect. 2014 Oct;122(10):1147-53. doi: 10.1289/ehp.1307892. PubMed PMID: 24906187; PubMed Central PMCID: PMC4181928.

12 Ju YS, Alexandrov LB, Gerstung M, Martincorena I, Nik-Zainal S, Ramakrishna M, Davies HR, Papaemmanuil E, Gundem G, Shlien A, Bolli N, Behjati S, Tarpey PS, Nangalia J, Massie CE, Butler AP, Teague JW, Vassiliou GS, Green AR, Du MQ, Unnikrishnan A, Pimanda JE, Teh BT, Munshi N, Greaves M, Vyas P, El-Naggar AK, Santarius T, Collins VP, Grundy R, Taylor JA, Hayes DN, Malkin D; ICGC Breast Cancer Group.; ICGC Chronic Myeloid Disorders Group.; ICGC Prostate Cancer Group., Foster CS, Warren AY, Whitaker HC, Brewer D, Eeles R, Cooper C, Neal D, Visakorpi T, Isaacs WB, Bova GS, Flanagan AM, Futreal PA, Lynch AG, Chinnery PF, McDermott U, Stratton MR, Campbell PJ. Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer. Elife. 2014 Oct 1;3. doi: 10.7554/eLife.02935. PubMed PMID: 25271376; PubMed Central PMCID: PMC4371858.

13 Harlid S*, Xu Z*, Panduri V‡, D'Aloisio AA, DeRoo LA, Sandler DP, Taylor JA. In utero exposure to diethylstilbestrol and blood DNA methylation in women ages 40-59 years from the sister study. PLoS One. 2015 Mar 9;10(3):e0118757. doi: 10.1371/journal.pone.0118757. PubMed PMID: 25751399; PubMed Central PMCID: PMC4353728.

14 Helfand BT, Roehl KA, Cooper PR, McGuire BB, Fitzgerald LM, Cancel-Tassin G, Cornu JN, Bauer S, Van Blarigan EL, Chen X, Duggan D, Ostrander EA, Gwo-Shu M, Zhang ZF, Chang SC, Jeong S, Fontham ET, Smith G, Mohler JL, Berndt SI, McDonnell SK, Kittles R, Rybicki BA, Freedman M, Kantoff PW, Pomerantz M, Breyer JP, Smith JR, Rebbeck TR, Mercola D, Isaacs WB, Wiklund F, Cussenot O, Thibodeau SN, Schaid DJ, Cannon-Albright L, Cooney KA, Chanock SJ, Stanford JL, Chan JM, Witte J, Xu J, Bensen JT, Taylor JA, Catalona WJ. Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases. Hum Genet. 2015 Apr;134(4):439-50. doi: 10.1007/s00439-015-1534-9. PubMed PMID: 25715684; PubMed Central PMCID: PMC4586077.

15 Hair BY, Xu Z*, Kirk EL, Harlid S*, Sandhu R, Robinson WR, Wu MC, Olshan AF, Conway K, Taylor JA, Troester MA. Body mass index associated with genome-wide methylation in breast tissue. Breast Cancer Res Treat. 2015 Jun;151(2):453-63. doi: 10.1007/s10549-015-3401-8. PubMed PMID: 25953686; PubMed Central PMCID: PMC4474159.

16 Wilson LE*, Kim S, Xu Z*, Harlid S*, Sandler DP, Taylor JA. Non-Steroidal Anti-Inflammatory Drug Use and Genomic DNA Methylation in Blood. PLoS One. 2015 Sep 22;10(9):e0138920. doi: 10.1371/journal.pone.0138920. PubMed PMID: 26393518; PubMed Central PMCID: PMC4578936.

17 Kim S†, Shore DL, Wilson LE*, Sanniez EI, Kim JH, Taylor JA, Sandler DP. Lifetime use of nonsteroidal anti-inflammatory drugs and breast cancer risk: results from a prospective study of women with a sister with breast cancer. BMC Cancer. 2015 Dec 16;15:960. doi:

10.1186/s12885-015-1979-1. PubMed PMID: 26673874; PubMed Central PMCID: PMC4682256.

18 Xu Z*, Niu L, Li L, Taylor JA. ENmix: a novel background correction method for Illumina HumanMethylation450 BeadChip. Nucleic Acids Res. 2016 Feb 18;44(3):e20. doi: 10.1093/nar/gkv907. PubMed PMID: 26384415; PubMed Central PMCID: PMC4756845.

19 Figueroa JD, Middlebrooks CD, Banday AR, Ye Y, Garcia-Closas M, Chatterjee N, Koutros S, Kiemeney LA, Rafnar T, Bishop T, Furberg H, Matullo G, Golka K, Gago-Dominguez M, Taylor JA, Fletcher T, Siddiq A, Cortessis VK, Kooperberg C, Cussenot O, Benhamou S, Prescott J, Porru S, Dinney CP, Malats N, Baris D, Purdue MP, Jacobs EJ, Albanes D, Wang Z, Chung CC, Vermeulen SH, Aben KK, Galesloot TE, Thorleifsson G, Sulem P, Stefansson K, Kiltie AE, Harland M, Teo M, Offit K, Vijai J, Bajorin D, Kopp R, Fiorito G, Guarrera S, Sacerdote C, Selinski S, Hengstler JG, Gerullis H, Ovsiannikov D, Blaszkewicz M, Castelao JE, Calaza M, Martinez ME, Cordeiro P, Xu Z, Panduri V, Kumar R, Gurzau E, Koppova K, Bueno-De-Mesquita HB, Ljungberg B, Clavel-Chapelon F, Weiderpass E, Krogh V, Dorronsoro M, Travis RC, Tjønneland A, Brennan P, Chang-Claude J, Riboli E, Conti D, Stern MC, Pike MC, Van Den Berg D, Yuan JM, Hohensee C, Jeppson RP, Cancel-Tassin G, Roupret M, Comperat E, Turman C, De Vivo I, Giovannucci E, Hunter DJ, Kraft P, Lindstrom S, Carta A, Pavanello S, Arici C, Mastrangelo G, Kamat AM, Zhang L, Gong Y, Pu X, Hutchinson A, Burdett L, Wheeler WA, Karagas MR, Johnson A, Schned A, Monawar Hosain GM, Schwenn M, Kogevinas M, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Andriole G Jr, Grubb R 3rd, Black A, Diver WR, Gapstur SM, Weinstein S, Virtamo J, Haiman CA, Landi MT, Caporaso NE, Fraumeni JF Jr, Vineis P, Wu X, Chanock SJ, Silverman DT, Prokunina-Olsson L, Rothman N. Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry. Hum Mol Genet. 2016 Mar 15;25(6):1203-14. doi: 10.1093/hmg/ddv492. PubMed PMID: 26732427; PubMed Central PMCID: PMC4817084.

20 Joubert BR, Felix JF, Yousefi P, Bakulski KM, Just AC, Breton C, Reese SE, Markunas CA, Richmond RC, Xu CJ, Küpers LK, Oh SS, Hoyo C, Gruzieva O, Söderhäll C, Salas LA, Baïz N, Zhang H, Lepeule J, Ruiz C, Ligthart S, Wang T, Taylor JA, Duijts L, Sharp GC, Jankipersadsing SA, Nilsen RM, Vaez A, Fallin MD, Hu D, Litonjua AA, Fuemmeler BF, Huen K, Kere J, Kull I, Munthe-Kaas MC, Gehring U, Bustamante M, Saurel-Coubizolles MJ, Quraishi BM, Ren J, Tost J, Gonzalez JR, Peters MJ, Håberg SE, Xu Z, van Meurs JB, Gaunt TR, Kerkhof M, Corpeleijn E, Feinberg AP, Eng C, Baccarelli AA, Benjamin Neelon SE, Bradman A, Merid SK, Bergström A, Herceg Z, Hernandez-Vargas H, Brunekreef B, Pinart M, Heude B, Ewart S, Yao J, Lemonnier N, Franco OH, Wu MC, Hofman A, McArdle W, Van der Vlies P, Falahi F, Gillman MW, Barcellos LF, Kumar A, Wickman M, Guerra S, Charles MA, Holloway J, Auffray C, Tiemeier HW, Smith GD, Postma D, Hivert MF, Eskenazi B, Vrijheid M, Arshad H, Antó JM, Dehghan A, Karmaus W, Annesi-Maesano I, Sunyer J, Ghantous A, Pershagen G, Holland N, Murphy SK, DeMeo DL, Burchard EG, Ladd-Acosta C, Snieder H, Nystad W, Koppelman GH, Relton CL, Jaddoe VW, Wilcox A, Melén E, London SJ. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7;98(4):680-96. doi: 10.1016/j.ajhg.2016.02.019. PubMed PMID: 27040690; PubMed Central PMCID: PMC4833289.

21 Wilson LE*, D'Aloisio AA, Sandler DP, Taylor JA. Long-term use of calcium channel blocking drugs and breast cancer risk in a prospective cohort of US and Puerto Rican women. Breast

Cancer Res. 2016 Jul 5;18(1):61. doi: 10.1186/s13058-016-0720-6. PubMed PMID: 27378129; PubMed Central PMCID: PMC4932734.

22 Goossens ME, Isa F, Brinkman M, Mak D, Reulen R, Wesselius A, Benhamou S, Bosetti C, Bueno-de-Mesquita B, Carta A, Allam MF, Golka K, Grant EJ, Jiang X, Johnson KC, Karagas MR, Kellen E, La Vecchia C, Lu CM, Marshall J, Moysich K, Pohlabeln H, Porru S, Steineck G, Stern MC, Tang L, Taylor JA, van den Brandt P, Villeneuve PJ, Wakai K, Weiderpass E, White E, Wolk A, Zhang ZF, Buntinx F, Zeegers MP. International pooled study on diet and bladder cancer: the bladder cancer, epidemiology and nutritional determinants (BLEND) study: design and baseline characteristics. Arch Public Health. 2016 Jul 6;74:30. doi: 10.1186/s13690-016-0140-1. PubMed PMID: 27386115; PubMed Central PMCID: PMC4933992.

23 Markunas CA†, Wilcox AJ, Xu Z*, Joubert BR, Harlid S*, Panduri V‡, Håberg SE, Nystad W, London SJ, Sandler DP, Lie RT, Wade PA, Taylor JA. Maternal Age at Delivery Is Associated with an Epigenetic Signature in Both Newborns and Adults. PLoS One. 2016 Jul 6;11(7):e0156361. doi: 10.1371/journal.pone.0156361. PubMed PMID: 27383059; PubMed Central PMCID: PMC4934688.

24 O'Brien KM, Shi M, Sandler DP, Taylor JA, Zaykin DV, Keller J, Wise AS, Weinberg CR. A family-based, genome-wide association study of young-onset breast cancer: inherited variants and maternally mediated effects. Eur J Hum Genet. 2016 Aug;24(9):1316-23. doi: 10.1038/ejhg.2016.11. PubMed PMID: 26883092; PubMed Central PMCID: PMC4989201.

25 Permuth JB, Pirie A, Ann Chen Y, Lin HY, Reid BM, Chen Z, Monteiro A, Dennis J, Mendoza-Fandino G; AOCS Study Group.; Australian Cancer Study (Ovarian Cancer)., Anton-Culver H, Bandera EV, Bisogna M, Brinton L, Brooks-Wilson A, Carney ME, Chenevix-Trench G, Cook LS, Cramer DW, Cunningham JM, Cybulski C, D'Aloisio AA, Anne Doherty J, Earp M, Edwards RP, Fridley BL, Gayther SA, Gentry-Maharaj A, Goodman MT, Gronwald J, Hogdall E, Iversen ES, Jakubowska A, Jensen A, Karlan BY, Kelemen LE, Kjaer SK, Kraft P, Le ND, Levine DA, Lissowska J, Lubinski J, Matsuo K, Menon U, Modugno R, Moysich KB, Nakanishi T, Ness RB, Olson S, Orlow I, Pearce CL, Pejovic T, Poole EM, Ramus SJ, Anne Rossing M, Sandler DP, Shu XO, Song H, Taylor JA, Teo SH, Terry KL, Thompson PJ, Tworoger SS, Webb PM, Wentzensen N, Wilkens LR, Winham S, Woo YL, Wu AH, Yang H, Zheng W, Ziogas A, Phelan CM, Schildkraut JM, Berchuck A, Goode EL, Pharoah PD, Sellers TA; Ovarian Cancer Association Consortium.. Exome genotyping arrays to identify rare and low frequency variants associated with epithelial ovarian cancer risk. Hum Mol Genet. 2016 Aug 15;25(16):3600-3612. doi: 10.1093/hmg/ddw196. PubMed PMID: 27378695; PubMed Central PMCID: PMC5179948.

26 Harlid S*, Adgent M, Jefferson WN, Panduri V‡, Umbach DM, Xu Z*, Stallings VA, Williams CJ, Rogan WJ, Taylor JA. Soy Formula and Epigenetic Modifications: Analysis of Vaginal Epithelial Cells from Infant Girls in the IFED Study. Environ Health Perspect. 2017 Mar;125(3):447-452. doi: 10.1289/EHP428. PubMed PMID: 27539829.

27 Niu L§, Xu Z*§, Taylor JA. RCP: a novel probe design bias correction method for Illumina Methylation BeadChip. Bioinformatics. 2016 Sep 1;32(17):2659-63. doi: 10.1093/bioinformatics/btw285. PubMed PMID: 27153672; PubMed Central PMCID: PMC5013906.

28 Saini N, Roberts SA, Klimczak LJ, Chan K, Grimm SA, Dai S, Fargo DC, Boyer JC, Kaufmann WK, Taylor JA, Lee E, Cortes-Ciriano I, Park PJ, Schurman SH, Malc EP, Mieczkowski PA,

Gordenin DA. The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts. PLoS Genet. 2016 Oct 27;12(10):e1006385. doi: 10.1371/journal.pgen.1006385. PubMed PMID: 27788131; PubMed Central PMCID: PMC5082821.

29 Kim S†, Campbell J, Yoo W, Taylor JA, Sandler DP. Systemic levels of estrogens and PGE2 synthesis in relation to postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2016 Nov 18. pii: cebp.0556.2016. [Epub ahead of print] PubMed PMID: 27864342.

30 Xu Z*, Taylor JA, Leung YK, Ho SM, Niu L. oxBS-MLE: an efficient method to estimate 5-methylcytosine and 5-hydroxymethylcytosine in paired bisulfite and oxidative bisulfite treated DNA. Bioinformatics. 2016 Dec 1;32(23):3667-3669. PubMed PMID: 27522082; PubMed Central PMCID: PMC5181539.

31 Amos CI, Dennis J, Wang Z, Byun J, Schumacher FR, Gayther SA, Casey G, Hunter DJ, Sellers TA, Gruber SB, Dunning AM, Michailidou K, Fachal L, Doheny K, Spurdle AB, Li Y, Xiao X, Romm J, Pugh E, Coetzee GA, Hazelett DJ, Bojesen SE, Caga-Anan C, Haiman CA, Kamal A, Luccarini C, Tessier D, Vincent D, Bacot F, Van Den Berg DJ, Nelson S, Demetriades S, Goldgar DE, Couch FJ, Forman JL, Giles GG, Conti DV, Bickeböller H, Risch A, Waldenberger M, Brüske-Hohlfeld I, Hicks BD, Ling H, McGuffog L, Lee A, Kuchenbaecker K, Soucy P, Manz J, Cunningham JM, Butterbach K, Kote-Jarai Z, Kraft P, FitzGerald L, Lindström S, Adams M, McKay JD, Phelan CM, Benlloch S, Kelemen LE, Brennan P, Riggan M, O'Mara TA, Shen H, Shi Y, Thompson DJ, Goodman MT, Nielsen SF, Berchuck A, Laboissiere S, Schmit SL, Shelford T, Edlund CK, Taylor JA, Field JK, Park SK, Offit K, Thomassen M, Schmutzler R, Ottini L, Hung RJ, Marchini J, Amin Al Olama A, Peters U, Eeles RA, Seldin MF, Gillanders E, Seminara D, Antoniou AC, Pharoah PD, Chenevix-Trench G, Chanock SJ, Simard J, Easton DF. The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers. Cancer Epidemiol Biomarkers Prev. 2017 Jan;26(1):126-135. doi: 10.1158/1055-9965.EPI-16-0106. PubMed PMID: 27697780; PubMed Central PMCID: PMC5224974.

32 Wilson LE*, Harlid S*, Xu Z*, Sandler DP, Taylor JA. An epigenome-wide study of body mass index and DNA methylation in blood using participants from the Sister Study cohort. Int J Obes (Lond). 2017 Jan;41(1):194-199. doi: 10.1038/ijo.2016.184. PubMed PMID: 27773939; PubMed Central PMCID: PMC5209267.

33 Shi M, O'Brien KM, Sandler DP, Taylor JA, Zaykin DV, Weinberg CR. Previous GWAS hits in relation to young-onset breast cancer. Breast Cancer Res Treat. 2017 Jan;161(2):333-344. doi: 10.1007/s10549-016-4053-z. PubMed PMID: 27848153; PubMed Central PMCID: PMC5226879.

34 Xu Z*, Langie SA, De Boever P, Taylor JA, Niu L. RELIC: a novel dye-bias correction method for Illumina Methylation BeadChip. BMC Genomics. 2017 Jan 3;18(1):4. doi: 10.1186/s12864-016-3426-3. PubMed PMID: 28049437; PubMed Central PMCID: PMC5209853.

35 O’Brien KM, Sandler DP, Taylor JA, Weinberg CR. Serum vitamin D and risk of breast cancer within five years. In Press, Environ Health Perspect.

36 Milne RL, Kuchenbaecker KB, Michailidou K, [numerous contributing authors including Taylor JA], Bader GD, Pharoah PDP, Couch FJ, Easton DF, Kraft P, Chenevix-Trench G, Garcia-

Closas M, Schmidt MK, Antoniou AC, Simard J. Identification of ten variants associated with risk of estrogen receptor negative breast cancer. In Press Nature Genetics.

37 Phelan CM, Kuchenbaecker KB, Tyrer JP, Kar SP, Lawrenson K, Winham SJ, [numerous contributing authors including Taylor JA], Chenevix-Trench G, Goode EL, Sellers TA, Gayther SA, Antoniou AC, Pharoah PDP. Identification of twelve novel susceptibility loci for different histotypes of epithelial 1 ovarian cancer. In Press, Nature Genetics.

Submitted manuscripts currently under review Michailidou K, Lindstrom S, Dennis J, Beesley J, Hui S, Kar S. [numerous contributing authors including Taylor JA] Simard J, Kraft P, Easton DF.Large-scale genetic association analysis identifies 65 new breast cancer susceptibility loci and predicts target genes. In revision at, Nature Genetics. Conti DV, Wang K, Sheng X [many contributing authors including Taylor JA], Haiman CA. Two novel susceptibility loci for prostate cancer in men of African ancestry.. Submitted. * Current or former postdoctoral fellow in Taylor group. † 2nd mentored postdoctoral fellow ‡Taylor Lab Biologist or student §Co-first author