January – February 2019

ReseaRch Bulletin

Bjorn R. Olsen, MD, PhD, Receives the 2019 King Faisal Prize in Medicine

Dr. Bjorn R. Olsen, professor of Developmental Biology, was recently selected to receive the 2019 King Faisal Prize in Medicine on the topic of Bone Biology and Osteoporosis. On the left, he is shown as an aspiring aspiring 22-year old medical student at the University of Oslo in Norway.

Olsen is awarded the 2019 King Faisal Prize in Medicine for his outstanding contributions to the field of bone biology. He has made a series of key genetic discoveries which have enhanced the understanding of bone development, and the basis of inherited skeletal disorders, including osteoporosis syndromes. These contributions have earned him international recognition and acclaim in the bone and osteoporosis fields. As a King Faisal Prize recipient, Olsen will travel to Saudi Arabia this Spring to receive this prestigious Award.

Gili Naveh, DMD, PhD, Receives the Eleanor and Miles Shore Fellowship

Dr. Gili Naveh, assistant professor of Oral Medicine, Infection and Immunity, was recently honored with an Eleanor and Miles Shore Fellowship Award for Scholars in Medicine. The Naveh Lab studies the structure–function relations in the periodontal ligament, in particular, and in ligaments in general. She aims to lead new discoveries in ligament and bone regeneration therapies as well as new approaches to generate controlled and predicted tooth movement.

Michael Baron Receives Research Award

Michael Baron, DMD candidate class of 2020, received the Student Research Training Award for his project, “Oral and Maxillofacial Surgery Chief Residents’ Perception of Training Deficits” under the mentorship of John Tannyhill III MD, DDS. The Award is funded by a grant from the Oral and Maxillofacial Surgery Foundation.

Dean Bruce Donoff celebrates this Award with Naveh and her family.

2 Research Bulletin • January – February 2019 • Harvard School of Dental Medicine

NEW RESEARCHERS SARAH BUI, MS, is the new research assistant in the Department of Oral Health Policy and Epidemiology. Bui has a BS in Health Promotion and Disease Prevention Studies and an MS in Global Medicine from the University of California. At HSDM, she

will provide research and programmatic support to HRSA-funded national centers – the National Center for the Integration of Primary Care and Oral Health and the National Center for Equitable Care for Elders.

TAKEHITO OCHI, DDS, PHD, originally from Shiga, Japan, joined the Yang Lab as a research fellow in the Department of Developmental Biology. Ochi graduated with a DDS from Tokyo Dental College and PhD from Keio University researching

mesenchymal stem cells and neural crest stem cells with somatic cells and iPS cell technology in the Department of Physiology. In the Yang Lab, he will focus on the skeletal stem cells in the craniofacial region.

JIACHEN LIN, PHD, joined the Yang Lab as a visiting graduate student in the Department of Developmental Biology. Lin comes to HSDM from the Department of Orthopedics at Peking Union Medical College Hospital, Beijing China. He received his MD degree from Shanghai Jiao Tong University

in 2017. Lin has been investigating the genetic causatives underpinning human congenital scoliosis. In the Yang Lab, he will focus on the role of WNT/PCP signaling in skeletal development.

BO LI, joined the Yang Lab as a visiting graduate student in the Department of Developmental Biology. Li comes from Chengdu, China. He is a doctoral student at the West China School of Stomatology, Sichuan University, majoring in Orthodontics. In the Yang Lab, Li is working on the mechanism of Enpp1 signaling in regulating

osteoblast differentiation and calcification in the joint and blood vessels, as well as the role of Wnt/PCP signaling in cartilage development.

MEET THE GIBBS LABThe Gibbs Lab is a translational research lab focused on the neurobiology of the dental pulp and dental pain. Jennifer Gibbs is an endodontist who completed her PhD in neuropharmacology and her dental training at the University of Texas Health Science Center. She is currently the Division Director of Endodontics at HSDM.

The Lab is studying the mechanisms by which bacterial products activate or sensitize sensory neurons. In a recently funded R56 award from NIDCR, they have identified pathways involving both transient potential ion channels and Toll-like receptors and are pursuing how these receptors interface in sensory neurons to produce bacterial mediated acute pain.

Another ongoing study is to understand how sensory neurons can influence dental pulp

stem cells in the mediation of repair and regeneration in the dental pulp. This project was funded by a grant from the American Association of Endodontics Foundation (AAEF), (Michot & Gibbs Principal Investigators). The Lab is completing a pilot cohort study to identify potential risk factors for more intense, or prolonged pain after endodontic surgery. Coupled to this study is an effort at biomarker discovery to identify molecular cues that predict pain outcomes. This research is funded by the AAEF (Gibbs Principal Investigator).

Dr. Benoit Michot is a postdoctoral research fellow in the Gibbs Lab in the Department of Restorative Dental and Biomaterials Sciences. Benoit completed his PhD in Neuroscience at the University of Paris, and was previously a postdoctoral fellow with Dr. Gibbs at NYU. This will continue his project on the mechanisms by which LPS activates sensory neurons. Benoit is also studying the neural modulation of dental pulp stem cells, using CGRP as a prototypical neuropeptide that is highly expressed in dental pulp.

Sharon Casey is a Research Associate in the Gibbs Lab in the Department of Restorative Dentistry and Biomaterials Sciences. She completed her undergraduate degree at the University College Cork in Ireland and completed her Master’s in Clinical Research at NYU this past May. Casey has expertise at the bench and in clinical research and is a certified study coordinator.

Michael Benoit, Jennifer Gibbs, Sharon Casey

Research Bulletin • January – February 2019 • Harvard School of Dental Medicine 3

Waring E, Mawardi H, Woo SB, Treister N, Margalit D, Frustino J, Villa A. Evaluation of a community-based dental screening program prior to radiotherapy for head and neck cancer: a single-center experience. Supportive Care in Cancer 2019; Jan 7.

Yang G, Wang J, Lu S, Chen Z, Fan S, Chen D, Xue H, Shi W, He J. Short lipopeptides specifically inhibit the growth of Propionibacterium acnes with antibacterial and anti-inflammatory dual action. British Journal of Pharmacology 2019; Jan 14.

ORAL AND MAxILLOFACIAL SURGERy Haeffs T, Scott C, Campbell T, Chen Y, August M. Acute and chronic suppurative osteomyelitis of the jaws: A 10-year review and assessment of treatment outcome. Journal of Oral and Maxillofacial Surgery 2018;76(12):2551-2558.

Ma G, Calabrese C, Donohue T, Peacock Z, Caruso P, Kaban L, Resnick C. Imaging of the temporomandibular joint in juvenile idiopathic arthritis: How does quantitative compare to semiquantitative MRI scoring? Journal of Oral and Maxillofacial Surgery 2018; Dec 11.

Pullano E, Ngo R, Peacock Z, Lahey E, August M. Is maxillomandibular advancement associated with comorbidity reduction in patients with obstructive sleep apnea? Journal of Oral and Maxillofacial Surgery 2018; Dec 17. Resnick C, LeVine J, Calabrese C, Padwa B, Hansen A, Katwa U. Early management of infants with Robin Sequence: An international survey and algorithm. Journal of Oral and Maxillofacial Surgery 2019;77(1):136-156.

Resnick C, Salcines A, Hughes C, Padwa B, Mulliken J. Retroposition of the globe after Le Fort III midfacial distraction. Journal of Craniofacial Surgery 2018; Dec 10.

Stoustrup P, Resnick C, Pedersen T, Abramowicz S, Michelotti A, Küseler A, Verna C, Kellenberger C, Berit Nordal E, Caserta G, Jankovska I, Halbig J, Kristensen K, Arvidsson L, Spiegel L, Stoll M, Lerman M, Glerup M, Defabianis P, Frid P, Alstergren P, Cron R, Ringold S, Nørholt S, Peltomäki T, Herlin T, Peacock Z, Twilt M. Standardizing terminology and assessment for orofacial conditions in juvenile idiopathic arthritis: International, multidisciplinary consensus-based recommendations. Journal of Rheumatology 2019; Jan 15.

MULTI-DEPARTMENTALLee K, Coull B, Moscicki A, Paster B, Starr J. Bayesian variable selection for multivariate zero-inflated models: Application to microbiome count data. Biostatistics 2018; Dec 26.

Nalliah R, Shroff D, Stein K, Chandrasekaran S, Rampa S, Allareddy V, Allareddy V. Opioid abuse and dependence in those hospitalized due to head and neck cancer. Journal of Oral and Maxillofacial Surgery 2018;76(12):2525-2531.

Nizam R, Alozairi E, Goodson J, Melhem M, Davidsson L, Alkhandari H, Al Madhoun A, Shamsah S, Qaddoumi M, Alghanim G, Alhasawi N, Abufarha M, Abubaker J, Shi P, Hartman M, Tavares M, Bitar M, Ali H, Arefanian H, Devarajan S, Al-Refaei F, Alsmadi O, Tuomilehto J, Al-Mulla F. Caveolin-1 variant is associated with the metabolic syndrome in Kuwaiti children. Frontiers in Genetics 2018; Dec 21;9:689.

continued on page 4

HSDM PUBLICATIONS DEvELOPMENTAL BIOLOGyGraf S, Vasudavan S, Wilmes B. CAD-CAM design and 3-dimensional printing of mini-implant retained orthodontic appliances. American Journal of Orthodontics and Dentofacial Orthopedics 2018;154(6):877-882.

Xu R, Khan SK, Zhou T, Gao B, Zhou Y, Zhou X, Yang Y. Gas signaling controls intramembranous ossification during cranial bone development by regulating both Hedgehog and Wnt/β-catenin signaling. Bone Research 2018;6:33.

ORAL MEDICINE, INFECTION AND IMMUNITyBartold P, Van Dyke T. An appraisal of the role of specific bacteria in the initial pathogenesis of periodontitis. Journal of Clinical Periodontology 2018; Dec 17. Delli K, Villa A, Farah C, Celentano A, Ojeda D, Peterson D, Jensen S, Glurich I, Vissink A. World Workshop on Oral Medicine VII: Biomarkers predicting lymphoma in the salivary glands of patients with Sjögren’s syndrome. A systematic review. Oral Diseases 2019; Jan 21.

Edlund A, Yang Y, Yooseph S, He X, Shi W, McLean J. Uncovering complex microbiome activities via metatranscriptomics during 24 hours of oral biofilm assembly and maturation. Microbiome 2018;6(1):217. Escapa I, Chen T, Huang Y, Gajare P, Dewhirst F, Lemon K. New insights into human nostril microbiome from the expanded human oral microbiome database (eHOMD): A resource for the microbiome of the human aerodigestive tract. mSystems 2018; 3(6).

Kim H, Wrann C, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, Chou J, Parkman V, Novick S, Strutzenberg T, Pascal B, Le P, Brooks D, Roche A, Gerber K, Mattheis L, Chen W, Tu H, Bouxsein M, Griffin P, Baron R, Rosen C, Bonewald L, Spiegelman B. Irisin mediates effects on bone and fat via aV ntegrin receptors.Cell 2018;175(7):1756-1768.

Liang S, Lv Z, Zhang J, Wang Y, Dong Y, Wang Z, Chen K, Cheng P, Yang Q, Guo F, Lu W, Zhu W, Chen A. Necrostatin-1 attenuates trauma-induced mouse osteoarthritis and IL-1β induced apoptosis via HMGB1/TLR4/SDF-1 in primary mouse chondrocytes. Frontiers in Pharmacology 2018;9:1378.

Markey L, Shaban L, Green E, Lemon K, Mecsas J, Kumamoto C. Pre-colonization with the commensal fungus Candida albicans reduces murine susceptibility to Clostridium difficile infection. Gut Microbes 2018;9(6):497-509.

Mendes R, Nguyen D, Stephens D, Pamuk F, Fernandes D, Hasturk H, Van Dyke T, Kantarci A. Hypoxia-induced endothelial cell responses - possible roles during periodontal disease. Clinical and Experimental Dental Research 2018;4(6):241-248.

Piet J, Hu D, Baron R, Shefelbine S. Bone adaptation compensates resorption when sciatic neurectomy is followed by low magnitude induced loading. Bone 2018;120:487-494.

Ridner S, Dietrich M, Sonis S, Murphy B. Biomarkers associated with lymphedema and fibrosis in patients with cancer of the head and neck. Lymphatic Research and Biology 2018; Nov 28.

4 Research Bulletin • January – February 2019 • Harvard School of Dental Medicine

A PUBLICATION OF THE OFFICE OF RESEARCH

188 longwood avenue – Boston, Massachusetts 02115 www.hsdm.harvard.edu– 617.432-1121

yingzi yang, PhD, Associate Dean for Translational ResearchMalcolm Whitman, PhD, Associate Dean for Basic Science

Dawn M. DeCosta, Editor and LayoutHeather M. Denny, Editing

Lia Sgourakes, Editing

PUBLICATIONS ORAL HEALTH POLICy AND EPIDEMIOLOGy

Cancedda C, ... , Barrow J, . . . Binagwaho A. Health professional training and capacity strengthening through international academic partnerships: The first five years of the human resources for health program in Rwanda. International Journal of Health Policy Management 2018;7(11):1024-39. Natto Z, Abu Ahmad R, Alsharif L, Alrowithi H, Alsini D, Salih H, Bissada N. Chronic periodontitis case definitions and confounders in periodontal research: A systematic assessment. BioMed Research International 2018;4578782. Neumann A, Kumar S, Bangar S, Kookal K, Spallek H, Tokede O, Simmons K, Even J, Mullins J, Mertz E, Yansane A, Obadan-Udoh E, White J, Walji M, Kalenderian E. Tobacco screening and cessation efforts by dental providers: A quality measure evaluation. Journal of Public Health Dentistry 2018; Dec 19.

Simon L, Tobey M. A national survey of medical school curricula on criminal justice and health. Journal of Corrective Health Care 2019; Jan 3.

RESTORATIvE DENTISTRy AND BIOMATERIALS SCIENCES

El Kholy K, Janner S, Schimmel M, Buser D. The influence of guided sleeve height, drilling distance, and drilling key length on the accuracy of static computer-assisted implant surgery. Clinical Implant Dental Related Research 2018; Dec 27.

Kobayashi T, Nagai M, Da Silva J, Galaburda A, Rosenberg S, Hatakeyama W, Kuwajima Y, Kondo H, Ishikawa-Nagai S. Retrograde transport of masseter muscle-derived neprilysin to hippocampus. Neuroscience Letters 2019; Jan 10.

Peng C, de Sousa F, Gan H, Kwon H, Park S, Kilpatrick-Liverman L, Wang W, Lavender S, Pilch S, Han J. Enhanced delivery of F-, Ca2+, K+, and Na+ ions into enamel by electrokinetic flows. Journal of Dental Research 2019; Jan 24.

Tso T, Hurwitz M, Margalit D, Lee S, Williams C, Rosen E. Radiation dose enhancement associated with contemporary dental materials. Journal of Prosthetic Dentistry 2018; Dec 20.

SAvE THE DATES

• HSDM RESEARCH DAy April 9, 2019, 9am –3pm, Research Poster Sessions

• DR. DONALD B. GIDDON LECTURE April 9, 2019, 12pm –1pm, Daniel Zlott, PharmD

• DR. PAUL GOLDHABER LECTURE April 10, 2019, 3pm–4pm, Paul Sharpe, PhD

SCIENCEFEBRUARY 20, 2019 • 11AM-12PM

HSDM REB AUDITORIUM • 190 LONGWOOD AVENUE

KAREN LYONS, PHD

SPEAKER SERIES

Professor of Molecular, Cell and DevelopmentalBiology; Professor of Orthopedic Surgery, DavidGeffen School of Medicine, UCLA

"Novel Crosstalk Between TGFβR1 and ALK1 in the Growth Plate"