january december 2012 - sunnybrook hospital name: amir pakdel sefidgar. university of toronto ......
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Rapid Response Radiotherapy Program (RRRP)
And Bone Metastases Site Group Clinic (BMC)
Annual Report
January–December 2012
Dr. Edward Chow Chair
Ms. Lori Holden Vice-Chair
Rapid Response Radiotherapy Program and Bone Metastases Site Group
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Executive Summary
On behalf of the Rapid Response Radiotherapy Program and the Bone Metastases Site Group
(RRRP/BMC), we are pleased to send you our 2012 annual report.
1. Clinics a) RRRP clinics: The number of patients seen annually in the five weekly half-day clinics
has reached a plateau of 500-600, eighty percent of which are new to OCC.
b) We have an advanced practice radiation therapist with the support of the Ministry of
Health (MOH).
2. Education a) Newsletter - Our readers indicated they found our quarterly newsletter HOT SPOT
informative and educational.
b) We continue to offer electives to palliative health care professionals from all over the
world to visit our Centre and learn about our programs.
3. Research a) We were successful in obtaining grant support both from peer reviewed granting
agencies and industries to continue our research projects.
b) Research students from Waterloo‘s co-op program have been extremely productive,
have also won numerous awards and have been successfully accepted to medical
schools and graduate degrees
4. Awards Dr. Urban Emmenegger
Research Summer Student Award, Sunnybrook Research Institute Prostate Cancer Canada (PCC) Clinician-Scientist Award
Dr. Arjun Sahgal
Meta-analysis evaluating stereotactic radiosurgery, whole brain radiotherapy, or both for
patients presenting with a limited number of brain metastases, Principal Author, Cancer.
118(9):2486-2493, 2012. European Association of Neuro-Oncology (EANO), Best Articles
in 2011-Sub-Section on Brain Metastases.
Clinical Scientist, Ontario Association of Radiation Oncologists (OARO), Toronto, Ontario,
Canada
Allan E. Tiffin Award, Odette Cancer Centre, Sunnybrook Health Sciences Centre,
Toronto, Ontario, Canada.
Department of Radiation Oncology, University of Toronto, Research Productivity Award,
Toronto, Ontario, Canada
Radiation Medicine Program, Princess Margaret Hospital, Best Radiation Medicine
Program Round for 2012, Toronto, Ontario, Canada
Ms. Emily Sinclair
Best Clinical Poster Award, Inaugural Joint University of Toronto and China Symposium:
Current Concepts in Spinal and Musculoskeletal Oncology
Dr. Cari Whyne
Winner of New Investigator Recognitions Award, Orthopaedic Research Society
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Nam D, Mau E, Wang Y, Silkstone D, Whyne CM, Alman B
Best Basic Science Presentation Award, Division of Orthopaedics Fellowship Day
Buchan L, Rogers BA, Akens MK, Wise-Milestone L, Whyne CM. The Biomechanical and
Stereological Effects of Pathological Proximal Femoral Lesions and Bisphosphonate
Treatment in a Murine Model
The Charles H. Tator Surgeon-Scientist Mentoring Award. The Surgeon Scientist Program
(SSP), University of Toronto
Gallie Bateman and McMurric Resident Research Award, Honorable Mention for choice of
subject, content and presentation, University of Toronto
Pakdel A, Whyne CM, Fialkov J.Correction of cortical bone geometry and intensity
information CT images
Gallie Bateman and McMurric Resident Research Award, Honorable Mention for choice of
subject, content and presentation, University of Toronto
Pezeshki P, Yee A, Whyne C, Preclincal ablation and MR imaging of bone metastasis
using a novel bipolar cooled radiofrequency (BCRF) probe
Winner of 2nd place for McMurrich Poster Award, Gallie Day, University of Toronto
Mau E, Wang Y, Wright D, Silkstone D, Whetstone H, Whyne CM, Alman B, Nam D. T-
Lymphoctyes enables osteoblast maturation via IL-17F during the early phase of fracture
repair
Frederick Banting and Charles Best Canada Graduate Scholarships, Supervisor: Cari
Whyne, Awardee Name: Hamid Ebrahimi. CIHR
Frederick Banting and Charles Best Canada Graduate Scholarships, Supervisor: Cari
Whyne, Awardee Name: Joshua Bernick. CIHR
Postgraduate Doctoral Scholarship, Supervisor: Cari Whyne (2011 - 2013), Awardee
Name: Zoryana Salo. Natural Sciences and Engineering Research Council of Canada
(NSERC)
Queen Elizabeth II graduate scholarships in science and technology, Supervisor: Cari
Whyne, Awardee Name: Padina Pezeshki
Ontario Graduate Scholarship, Supervisor: Cari Whyne, Awardee Name: Amir Pakdel
The Barbara and Paul Frank Milligan Graduate Fellowship. Supervisor: Cari Whyne.
Awardee Name: Mikhail Burke. University of Toronto
Best Translational Poster Award, Inaugural Joint University of Toronto and China
Symposium on Current Concepts in Spinal and Musculoskeletal Oncology. Toronto.
Awardee: Padina Pezeshki
Paul Madsen Award, Supervisor: Cari Whyne, Awardee Name: Hamid Ebrahimi. IBBME
University of Toronto
Anne Jamieson Award, Supervisor: Cari Whyne, Awardee Name: Zoryana Salo. IBBME
University of Toronto
2012 Summer Studentship Award, Supervisor: Cari Whyne, Awardee Name: Edwin
Wong. Sunnybrook Research Institute
School of graduate studies - Winter 2012 conference grant. Supervisor: Cari Whyne,
Awardee Name: Padina Pezeshki. University of Toronto
The Barbara and Paul Frank Milligan Graduate Fellowship. Supervisor: Cari Whyne,
Awardee Name: Hamid Ebrahimi. University of Toronto
The Barbara and Paul Frank Milligan Graduate Fellowship. Supervisor: Cari Whyne,
Awardee Name: Amir Pakdel Sefidgar. University of Toronto
Dr. Albert Yee
2013 American British Canadian (ABC) International Travelling Fellowship (Tour
scheduled April/May 2013), Canadian Orthopaedic Association
2011 J. Edouard Samson Award, Canadian Orthopaedic Foundation, Canada.
A Sunnybrook Moment of Service Excellence, Sunnybrook Health Sciences Centre,
Toronto
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11th Annual Charles H. Tator Surgeon-Scientist Mentoring Award, University of Toronto,
Toronto
Global Talent Search Finalist. Technology, Entertainment, Design (TED). Supervisor:
Albert Yee, Awardee Name: Padina Pezeshki
Fellowship, MASc (Cand), IBBME, U of T, Co-Supervisor: Albert Yee, Awardee Name:
Ebrahimi, Hamid. University of Toronto Fellowship, IBBME, Ontario, Canada
IMS Open Fellowship Award, PhD (Cand), IMS, Supervisor: Albert Yee, Awardee Name:
Du, William (Weidong). University of Toronto - IMS, Ontario, Canada
5. Promotions Dr. Cari Whyne
Promoted to Professor
Dr. Arjun Sahgal
Promoted to Associate Professor
6. Our Quality Assurance rounds resulted in several published case reports.
This report summarizes our very successful year and the academic activities of the RRRP/BMC.
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Odette Cancer Centre Rapid Response Radiotherapy Program (RRRP)
2012
The membership of the RRRP included:
Radiation Oncologists Pharmacists
Edward Chow (Chair) Carlo DeAngelis
Toni Barnes Mark Pasetka
Cyril Danjoux Angie Giotis
Arjun Sahgal
May Tsao Medical Physicist
Patrick Cheung (Oligometastases Program) Gordon Chan
Kristopher Dennis (Fellow)
Radiation Therapists
Lori Holden (Vice-Chair)
Natalie Lauzon
Nurses
Matina Floros
Maryon Walter
Michelle Ross
Jennifer Smith
Lida Ahmadi
Tanya Holownych
Liliana Jude
Erin O‘Grady
Diane Pineau
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Odette Cancer Centre Bone Metastases Site Group
2012
The membership of the BMC included:
Radiation Oncologists Radiation Therapists
Edward Chow (Chair) Lori Holden (Vice-Chair)/Emily Sinclair
Toni Barnes Natalie Lauzon
Cyril Danjoux
Arjun Sahgal Nurses
May Tsao Macey Farhadian
Kristopher Dennis (Fellow) Sima Farhangi-Manesh
Orthopedic Surgeons Pharmacists
Joel Finkelstein Carlo DeAngelis
Michael Ford Mark Pasetka
Albert Yee Angie Giotis
Radiologists Medical Physicist
Monique Christakis Gordon Chan
Andrea Donovan
Linda Probyn Biomechanical Engineer
Robyn Pugash Cari Whyne
Joel Rubenstein
Medical Oncologist
Urban Emmenegger
Palliative Care Physician
Jeff Myers
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EDUCATION
The RRRP publishes a quarterly newsletter ―HOT SPOT‖ and provides educational electives for
students and health care professionals interested in palliative radiotherapy.
Hot Spot Newsletter
In response to a satisfaction survey from our referring physicians who wanted better
communication, we initiated a quarterly newsletter in 1999 called ―HOT SPOT‖.
HOT SPOT is the educational newsletter of the RRRP at OCC. It is published quarterly and
distributed to oncologists, palliative care specialists, family doctors and professional health care
workers in palliative medicine. Our readership has expanded to over 2,000 per issue and we
continue to expand our circulation to new readers. Survey results from our readers rated the
educational value of HOT SPOT as high and suggested that we add other topics of interest. We
increased the content of our newsletter from four to six pages with additional sections and
contributors. The newsletter has regular articles on the following topics:
ETHICS
RESEARCH
PSYCHOSOCIAL
ADVICE FROM PHARMACIST
EDUCATIONAL ACTIVITIES
EDUCATIONAL INSERT
Each issue also has a double-sided educational insert.
The Editorial Board of Hot Spot
Founders Drs. L. Andersson and C. Danjoux
Editor Dr. E. Chow
Associate Editor Dr. C. Danjoux
Consultant Dr. S. Wong
Advisors Dr. E. Barnes, Dr. R. Goldman, Dr. A. Husain, Dr. L. Librach,
Ms. N. Lauzon, Dr. A. Sahgal, Ms. L. Holden, Dr. E. Szumacher,
Dr. M. Tsao
Editorial & Financial Manager Ms. S. Yuen
The publication of the newsletter is made possible by the financial support of pharmaceutical &
radiotherapy equipment companies.
The newsletter is also available electronically on the OCC web site:
http://www.sunnybrook.ca/content/?page=OCC_rrrp_about
[Appendix E provides the content of previous issues and inserts of HOT SPOT from
1999-2012.]
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Educational Electives
As part of our undergraduate teaching, students from the co-op program at the University of
Waterloo have their electives working with the RRRP-BMC. This co-operative educational elective has
been extremely successful.
Awards
Stephanie Hadi (in clinic 2007), occupational therapy master student
2012 Ontario Graduate Scholarship
2012 Thelma Cardwell Prize in Research
2012 Jenny Lau Memorial Award
Nemica Thavarajah (in clinic 2010-present), undergraduate student
2012 Marion J. Todd Memorial Award, Faculty of Applied Health Sciences, University of
Waterloo
2012 Co-op Student of the Year for Faculty of Applied Health Science, University of
Waterloo
Liang Zeng (in clinic 2010-2012), undergraduate student
2012 MASCC/ISOO Investigator of the Year Award
[Appendix F – Undergraduate Teaching–Co-op Program]
Health Care Professionals Electives
The RRRP provides an orientation for other health care professionals to experience the activities of
the RRRP clinics. Drs. Florence Mok and Kenneth Li from Hong Kong, Ms. Krista McGrath (CSRT) from
Credit Valley Hospital, Ms. Kittikorn Nilmanat (nurse) from Thailand, Ms. Mary Job from Australia, Ms.
Susan Horsman (nurse) and Ms. Bronwen LeGuerrier (RT) from Edmonton, Alberta spent a couple of
days with us as they plan to start a similar project in their Centres. They found the experience
valuable and recommend it for others planning to start a similar program.
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RESEARCH
The RRRP/BMC team objective is to provide palliative radiotherapy in an academic environment.
We participate in local, national and international clinical trials, have regular research rounds and
have been successful in securing grants to fund our research projects.
Clinical Trials
We participate in several clinical trials. The research students have been an essential resource in
helping us to enroll, follow-up, analyze and publish our studies. Without the dedication of our
research students, it would have been difficult to successfully complete our research studies.
[Appendix G - A list of ongoing research studies in the RRRP and BMC]
CPROG (Canadian Palliative Radiation Oncology Group)
Our collaboration with Princess Margaret Hospital (PMH) and the Hamilton Regional Cancer Centre
Palliation Radiation Oncology Group, led to the formation of the Palliative Radiotherapy Oncology
Group Ontario (PROG-O) in 2000. Since then PROG-O has expanded to include Cancer Centres
from the Maritimes, Manitoba, Calgary and British Columbia. Currently, this group meets monthly
through videoconference. This has improved communication between the staff involved in the
palliative radiotherapy program in those Centres and offered the opportunity for collaboration in
research. At the last CARO meeting, more Cancer Centres expressed enthusiasm in participating in
PROG-O rounds.
PROG-O offers a national forum for monthly research discussion in palliative radiotherapy. Over the
past years the coordinators for the PROG-O rounds have been Drs. J. Wu, A. Bezjak, R. Wong and
T. Barnes. The rounds are scheduled for the last Tuesday of every month.
To represent the change in participation from Ontario to Cancer Centres across Canada we
renamed the group as Canadian Palliative Radiation Oncology Group (CPROG)
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Videoconference Rounds (CPROG)
The subjects discussed during 2012 were:
2012 Title Presenter(s)
January 31 Can trained volunteers provide psychosocial support to
patients undergoing radiotherapy? The perspective of
patients and volunteers
Ms. Dhara Moddel
Dr. Rinat Nissim
PMH
March 27 A proposal for a prospective multicentre Phase III
randomized trial: Palliative radiation doses in
abdominal-pelvic soft tissue metastases
Dr. Ericka Wiebe
Dr. Gillian Thomas
OCC
April 17 1) Should bone metastases causing neuropathic
pain be treated with higher dose conventional
palliative radiotherapy?
2) Phase III study of palliative radiotherapy for
hepatocellular carcinoma and liver metastases
Dr. Kristopher Dennis
OCC
and
Dr. Laura Dawson
PMH
May 29 Epistemological ruminations & selected bone metastases
cases referred for palliative radiotherapy
Dr. Jackson Wu
TBCC
October 16 Steroid – A necessary evil in brain mets Dr. R. Koul
ABCC
November 20 Radiopharmaceuticals for bone pain Dr. Glenn Bauman
LHSC
December 18 Palliative radiation for painful bony metastases;
volumetric planning superior?
Dr. Rachel Micallef
PMH
*Rounds cancelled in February, June, July, August & September
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RRRP and BMC Monthly Meetings
The subjects discussed during 2012 were:
2012 Title Presenter(s)
January 17 RRRP Presentation – Rapid Onset Opioids-Redefining
treatment of breakthrough pain
(Chaired by Dr. Kristopher Dennis)
Dr. Marissa Slaven
January 23 RRRP Presentation – Fitness to drive in brain tumour
patients: A gray matter
(Chaired by Dr. Kristopher Dennis)
Dr. Alexander Louie
February 7 RRRP Quality Assurance Round
(Chaired by Dr. May Tsao)
Ms. Gillian Bedard
Mr. Liang Zeng
February 21 RRRP Presentation – Management of seizure in brain
metastases patients
(Chaired by Dr. Toni Barnes)
Dr. Esther Bui
March 6 RRRP Business Meeting
(Chaired by Dr. Edward Chow)
All
April 17 RRRP Presentation – Onsolis Study
(Chaired by Dr. Edward Chow)
Dr. Edward Chow
May 1 RRRP Presentation – Everyone has a role to play in
responsible opioid prescribing
(Chaired by Dr. Carlo DeAngelis)
Dr. Erica Weinberg
May 15 RRRP Presentation – HPCO and MASCC poster
presentations
(Chaired by Mr. Liang Zeng)
Ms. Nemica
Thavarajah
Ms. Michelle Zhou
June 5 RRRP Presentation – MASCC poster presentations
(Chaired by Dr. Kristopher Dennis)
Ms. Natalie Lauzon
Ms. Julia Di Giovanni
Ms. Gemma
Cramarossa
June 19 RRRP Presentation – MASCC oral/poster presentations
(Chaired by Dr. Kristopher Dennis)
Mr. Andrew Leung
Mr. Michael Poon
Mr. Marko Popovic
Mr. Liang Zeng
July 3 RRRP Presentation – RRRP clinical trials
(Chaired by Ms. Lori Holden)
Ms. Lori Holden
July 17 RRRP Presentation – Finding the balance in the
management of bone metastases – Is it time to rethink
dosing intervals of anti-osteoclastic agents?
(Chaired by Dr. Edward Chow)
Dr. Christine
Simmons
August 7 RRRP Presentation – Radiotherapy-induced nausea and
vomiting: Current controversies, challenges and the
path to progress
(Chaired by Ms. Natalie Lauzon)
Dr. Kristopher Dennis
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August 14 RRRP Presentation – RRRP student welcome and
farewell
(Chaired by Dr. Edward Chow)
Dr. Edward Chow
September 4 RRRP Presentation – Meaningful change in oncology
quality of life instruments: Most recent research and
future steps
(Chaired by Ms. Lori Holden)
Ms. Gillian Bedard
September 17 RRRP Quality Assurance Round
(Chaired by Dr. Edward Chow)
Dr. Edward Chow
October 2 RRRP Presentation – RFA assisted vertebroplasty
(Chaired by Ms. Natalie Lauzon)
Dr. Elizabeth David
October 16 RRRP/BMC annual general meeting
(Chaired by Dr. Edward Chow)
Dr. Edward Chow
November 6 RRRP Presentation – Microbubble ultrasound in animal
bone mets
(Chaired by Ms. Gillian Bedard)
Dr. Gregory Czarnota
Dr. Cari Whyne
Dr. Albert Yee
November 20 RRRP Presentation – Review of twenty patients treated
with sublingual fentanyl tablets for breakthrough cancer
pain in outpatient cancer center
(Chaired by Ms. Lori Holden)
Dr. Marissa Slaven
December 4 RRRP Quality Assurance Round
(Chaired by Ms. Gillian Bedard)
Ms. Natalie Lauzon
Ms. Erin Wong
December 18 RRRP Business Meeting
(Chaired by Dr. Edward Chow)
All
*Rounds cancelled: March 20, April 3
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Grants Akens MA, Whyne CM, Nam D, Wilson BC, Yee AJM. Photodynamic therapy treatment to enhance
fracture healing. Congressionally Directed Medical Research Program (2010 – 2013). $100,000
USD
Dennis K, Chow E (Supervisor). Radiation-Induced Nausea and Vomiting (RINV): Part 1) An
international survey of patterns of practice for RINV prophylaxis among radiation oncologists.
Part 2) A pilot study investigating the efficacy of Aprepitant and Granisetron for the prophylaxis
of (RINV). Canadian Institutes of Health Research (CIHR) Fellowship Award – Priority Area: In
the Area of Clinical Research (2011 – 2013). $110,000
Emmenegger U. Hypoxia: a mediator of PSA surge in prostate cancer patients undergoing
antiangiogenic therapy? University of Toronto Dean‘s Fund (2009 – 2014). $10,000
Emmenegger U. Metronomic chemotherapy in castration-resistant prostate cancer: Overcoming
treatment resistance. Prostate Cancer Canada (2010 – 2012). $300,000
Hall R, Ashcroft A Timothy J, Cook G, Kapur N, Whyne CM, Arthrocare UK Ltd. Developing
Optimised Vertebroplasty Treatments for Vertebral Fractures in Multiple Myeloma. Engineering
and Physical Sciences Research Council (EPSRC) (UK) (2010 – 2014). $571,281 GBP
Mainprize T, Sahgal A, Hynynen K, Tsao M. A study to evaluate the safety and feasibility of
transcranial MRI-Guided focused ultrasound surgery in the treatment of brain tumors. MR Guided
Focused Ultrasound Foundation (2010 – present). $287,717
Sahgal A, Aviv R, Stanisz G. Early prediction of response for brain metastases following
stereotactic radiosurgery and hypofractionated stereotactic radiosurgery using perfusion and
apoptosis quantification MRI. Odette Cancer Center Allan E. Tiffin Trust (2012 – present).
$45,000
Sahgal A, Laperriere JN, Massicotte E, Lewis S, Rampersaud R, Fehlings F, Xu W, Letourneau D,
Yu E. A phase II study to determine efficacy of stereotactic body radiotherapy (SBRT) for
spinal/para-spinal metastases –sub-section on CT perfusion. Spinal Research Foundation (2012 –
present). $10,000
SC23 - A randomized phase III double blind study of dexamethasone versus placebo in the
prophylaxis of radiation-induced pain flare following palliative radiotherapy for bone metastases.
NCIC-CTG. National Cancer Institute of Canada.
Sherar M, Murphy K, Whyne CM, Yee A, McCann C. Novel Radio Frequency Ablation Technology
for Treatment of Solid Tumours in Bone. The Ontario Centres of Excellence (OCE) – MaRS
Innovation (MI) Competitive Institutional Proof of Principle Program (CIPoP) (2011 – 2012).
$199,900 (100k from industry partner Bard Canada)
Sunderland I, Antonyshyn O, Mainprize J, Whyne CM. Comparative impact resistance of titanium
mesh, polymethyl methacrylate (PMMA), and polyether ether ketone (PEEK) in an in vitro model
of custom, patient-specific cranioplasty. AO Foundation Start up Grant (2012). $53,900 CHF
Whyne C, Yee AJ, Finkelstein JA. Bone stability and tumor burden in the metastatic spine:
implications of variable disease patterns. Canadian Institute of Health Research (2008 - 2012).
$379,862
Whyne CM and Yee A. FLEX FiRST Wire – A novel device to facilitate long bone fracture
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reduction. The Ontario Centres of Excellence (OCE) – MaRS Innovation (MI) Competitive
Institutional Proof of Principle Program (CIPoP) (2012 – 2013). $10,000
Whyne CM, Aubert I, Chopra R, Staniscz G, Hynynen K, Finkelstein J, Yee A. Therapeutics and
imaging for the injured spinal cord: MRI guided focused ultrasound and viral delivery across the
blood spinal cord barrier - A pilot study. Centre for Spinal Trauma (2011 – 2012). $40,000
Whyne CM, Fialkov J, Regev E, Santerre P. Development of a Novel Method for Stabilizing
Traumatic Craniofacial Injuries. Congressionally Directed Medical Research Program (2010 –
2012). $100,000 USD
Whyne CM, Fialkov J, Santerre P, Pilliar R. Development of a novel device & method for
stabilizing traumatic craniofacial injuries. The Ontario Centres of Excellence (OCE) – MaRS
Innovation (MI) Competitive Institutional Proof of Principle Program (CIPoP) (2012 – 2013).
$35,000
Whyne CM, Yee A, Willett T, Akens M, Barzda V, Boyd D, Grynpas M, Kiss A, Niebur G, Sone E.
Implications of pathologic changes to bone material properties on the skeletal stability of the
metastatic spine. Canadian Institute of Health Research (CIHR), Operating grant – Priority
Announcement: Breast Cancer (2012 – 2013). $100,000
Whyne CM, Yee AJM, Finkelstein JA. Bone stability and tumor burden in the metastatic spine:
Implications of variable disease patterns. Canadian Institutes of Health Research (CIHR) (2008 –
2012). $440,974
Whyne CM. Multi-resolution modeling of thin bone structures in the Human skeleton. Natural
Sciences and Engineering Research Council of Canada (NSERC). Discovery Grant (2011 – 2015).
$245,000
Yee A, Fehlings M, Webster F, Ahn H, Ginsberg H, and UT Spine Program. Moving from
Knowledge to Action: The University of Toronto Spine Collaborative (UT-SpineLINK) Phase II
Proposal in the Implementation of Knowledge Translation Strategies. MOH-LTC, OMA, Ontario
Academic Health Sciences Centre Agreement. Alternate Funding Plan Phase III Innovation Funds
(2011 – 2013). $100,000
Yee A, Whyne C, Akens M, Sahgal A, Chow E, Wilson B, Bisland S, Clemons M. A phase I trial on
the use of PDT in the treatment of breast cancer vertebral metastasis. Canadian Breast Cancer
Foundation (2009 – 2012). $300,850
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Publications Balagamwala EH, Cherian S, Angelov A, Suh JH, Djemil T, Lo SS, Sahgal A, Chang EL, Teh BS,
Chao ST. Stereotactic body radiotherapy for the treatment of spinal metastases. Journal of
Radiation Oncology 1(3): 255-265, 2012.
Bedard G, Zeng L, Lam H, Cella D, Zhang L, Lauzon N, Chow E. Meaningful Change in Oncology
Quality of Life Instruments: A Systematic Literature Review. Expert Review of
Pharmacoeconomics and Outcomes Research 12(4): 475-483, 2012.
Bedard G, Zeng L, Lam H, Lauzon N, Hicks K, Chow E. Positron emission tomography and bone
metastases – A review of the literature. Journal of Pain Management 5(4): 331-345, 2012.
Bedard G, Zeng L, Lauzon N, Probyn L, Dennis K, Chow E. Heterotopic ossification: Mimics of
other benign and malignant etiologies. Journal of Pain Management 5(4): 357-360, 2012.
Bedard G, Zeng L, Verma S, Lauzon N, Holden L, Dennis K, Poon M, Chow E. Osteonecrosis of
the jaw appearing as bone metastases in bone scan in a patient breast cancer. Journal of Pain
Management 5(4): 361-363, 2012.
Boehling N, Chang E, Ma L, Phan N, Yeung R, Sahgal A. Stereotactic radiosurgery for brain
metastases: Current status and future directions. Journal of Radiation Oncology 1(3):245-253,
2012.
Caissie A, Culleton S, Nguyen J, Zhang L, Zeng L, Holden L, Dennis K, Chan E, Jon F, Tsao M,
Danjoux C, Sahgal A, Barnes E, Koo K, Chow E. EORTC QLQ-C15-PAL Quality of life scores in
patients with advanced cancer referred for palliative radiotherapy. Supportive Care in Cancer
20(4):841-848, 2012.
Caissie A, Nguyen J, Chen E, Zhang L, Sahgal A, Clemons M, Kerba M, Foro Arnalot P, Danjoux C,
Tsao M, Barnes E, Holden L, Danielson B, Chow E. Quality of life in patients with brain
metastases using the EORTC QLQ-BN20+2 and QLQ-C15-PAL. International Journal of Radiation
Oncology, Biology and Physics 83(4): 1238-1245, 2012.
Caissie A, Zeng L, Nguyen J, Zhang L, Jon F, Dennis K, Holden L, Culleton S, Koo K, Tsao M,
Barnes E, Danjoux C, Sahgal A, Simmons C, Chow E. Assessment of health-related quality of life
with the EORTC QLQ-C15-PAL after palliative radiotherapy of bone metastases. Clinical Oncology
24(2): 125-133, 2012.
Chen E, Cella D, Zeng L, Thavarajah N, Zhang L, Chang E, Sahgal A, Bennett M, Peckham K, De
Costa S, Beaumont J, Tsao M, Danjoux C, Barnes E, Chow E. Content validation of the FACT-Br
with patients and health care professionals to assess quality of life in patients with brain
metastases. Journal of Radiation Oncology (published online July 18, 2012).
Chen E, Khan L, Zhang L, Nguyen J, Cramarossa G, Tsao M, Danjoux C, Barnes E, Sahgal A,
Holden L, Jon F, Dennis K, Chow E. Symptom clusters in patients with advanced cancer – sub
analysis of patients reporting exclusively non-zero ESAS scores. Palliative Medicine 26(6): 826-
833, 2012.
Chen E, Khan L, Zhang L, Nguyen J, Cramarossa G, Tsao M, Danjoux C, Barnes E, Sahgal A,
Holden L, Jon F, Dennis K, Culleton S, Chow E. Symptom clusters in patients with bone
metastases – a reanalysis comparing different statistical methods. Supportive Care in Cancer
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20(11): 2811-2820, 2012.
Chen E, Khan L, Zhang L, Nguyen J, Zeng L, Bedard G, Tsao M, Danjoux C, Barnes E, Sahgal A,
Holden L, Jon F, Dennis K, Chow E. Symptom clusters in patients with brain metastases - a
reanalysis comparing different statistical methods. Journal of Radiation Oncology (published
online May 6, 2012).
Chen E, Nguyen J, Khan L, Zhang L, Cramarossa G, Tsao M, Danjoux C, Barnes E, Sahgal A,
Holden L, Jon F, Chow E. Symptom clusters in patients with advanced cancer – a reanalysis
comparing different statistical methods. Journal of Pain and Symptom Management 44(1): 23-
32, 2012.
Chen E, Nguyen J, Zhang L, Zeng L, Holden L, Lauzon N, Bedard G, Koo K, Mingay A, Danjoux C,
Sahgal A, Tsao M, Barnes E, Chow E. Quality of Life in Patients with Brain Metastases using the
EORTC QLQ-BN20 and QLQ-C30. Journal of Radiation Oncology 1(2): 179-186, 2012.
Chiu L, Chiu N, Zeng L, Zhang L, Popovic M, Chow R, Lam H, Poon M, Chow E. Quality of life in
patients with primary and metastatic brain cancer as reported in the literature using the EORTC
QLQ-BN20 and QLQ-C30. Expert Review of Pharmacoeconomics & Outcomes Research 12(6):
831-837, 2012.
Chow E, Hahn C, Lutz S. The continued global reluctance to practice evidence-based medicine in
the treatment of uncomplicated painful bone metastases despite level 1 evidence and practice
guidelines. International Journal of Radiation Oncology, Biology, Physics 83(1): 1-2, 2012.
Chow E, Hoskin P, Mitera G, Zeng L, Lutz S, Roos D, Hahn C, van der Linden Y, Hartsell W,
Kumar E on behalf of the International Bone Metastases Consensus Working Party. Update of the
international consensus on palliative radiotherapy endpoints for future clinical trials in bone
metastases. International Journal of Radiation Oncology, Biology and Physics 82(5): 1730-1737,
2012.
Chow E, Nguyen J, Zhang L, Tseng L, Hou M, Fairchild A, Vassiliou V, Jesus-Garcia R, Alm El-Din
MA, Kumar A, Forges F, Chie W, Bottomley A, on behalf of the EORTC Quality of Life Group.
International field testing of the reliability and validity of the EORTC-QLQ-BM22 module to assess
health-related quality of life in patients with bone metastases. Cancer 118(5): 1457-1465, 2012.
Chow E, Zeng L, Salvo N, Dennis K, Tsao M, Lutz S. Update on the systemic review in palliative
radiotherapy trials for bone metastases. Clinical Oncology 24(2): 112-124, 2012.
Cox B, Spratt DE, Lovelock M, Bilsky M, Lis E, Ryu S, Sheehan J, Gerszten P, Chang E, Gibbs I,
Soltys S, Sahgal A, Deasy J, Yamada Y. International spine radiosurgery consortium consensus
guidelines for target volume definition in spinal stereotactic radiosurgery. International Journal of
Radiation Oncology, Biology and Physics 83(5): e597-605, 2012.
Cunha M, Al-Omair A, Atenafu E, Masucci GL, Letourneau D, Korol R, Yu E, Howard P, Lochray F,
da Costa L, Fehling MG, Sahgal A. Vertebral compression fracture (VCF) post-spine stereotactic
body radiotherapy (SBRT): Analysis of predictive factors. International Journal of Radiation
Oncology, Biology and Physics 84(3): e343-349, 2012.
Dennis K, Makhani L, Maranzano E, Feyer P, Zeng L, De Angelis C, Holden L, Wong CS, Chow E.
Timing and duration of 5-HT3 receptor antagonist therapy for the prophylaxis of radiotherapy-
induced nausea and vomiting: a systematic review of randomized and non-randomized studies.
Journal of Radiation Oncology (published online May 11, 2012).
17
Dennis K, Nguyen J, Presutti R, DeAngelis C, Tsao M, Danjoux C, Barnes E, Sahgal A, Holden L,
Jon F, Wong S, Chow E. Prophylaxis of radiotherapy-induced nausea and vomiting in the
palliative treatment of bone metastases. Supportive Care in Cancer 20(8): 1673-1678, 2012.
Dennis K, Vassiliou V, Balboni T, Chow E. Management of bone metastases: recent advances and
current status. Journal of Radiation Oncology 1(3): 201-210, 2012.
Dennis K, Zhang L, Lutz S, van Baardwijk A, van der Linden Y, Holt T, Foro Arnalot P, Lagrange
JL, Maranzano E, Liu R, Wong KH, Wong LC, Vassilios V, Corn BW, De Angelis C, Holden L, Wong
CS, Chow E. International patterns of practice in the management of radiotherapy-induced
nausea and vomiting. International Journal of Radiation Oncology, Biology and Physics 84(1):
e49-e60, 2012.
Di Prospero L, Thavarajah N, Chen E, Jon F, Chow E, Holden L. Pain Management Needs
Assessment: A Survey of Radiation Therapists at a large academic comprehensive cancer centre.
Journal of Medical Imaging and Radiation Sciences 43: 214-220, 2012.
Du WW, Fang L, Yang W, Sheng W, Zhang Y, Seth A, Yang BB, Yee AJ. The role of versican G3
domain in regulating breast cancer cell motility including effects on osteoblast growth and
differentiation in vitro - evaluation towards understanding breast cancer cell bone metastasis.
BMC Cancer 12: 341, 2012.
Follwell M, Khu KJ, Cheng L, Xu W, Mikulis D, Millar BA, Tsao MN, Laperriere NJ, Bernstein M,
Sahgal A. Volume specific response criteria for brain metastases following salvage stereotactic
radiosurgery and associated predictors of response. Acta Oncologica 51(5):629-635, 2012.
Guckenberger M, Sweeney RA, Flickinger JC, Gerszten PC, Sheehan J, Sahgal A. Clinical practice
of image-guided spine radiosurgery-results from an international research consortium. Radiation
Oncology 6(1):1-11, 2012.
Haid V, Kumar K, Al Duhaiby E, Pang J, DeAngelis C, Pasetka M, Ko Y, Nguyen J, Dennis K, Chow
E, Chung HT. Evaluation of a daily diary for assessing the prevalence of radiation-induced emesis
(RIE). Journal of Pain Management 5(3): 237-244, 2012.
Hardisty MR, Akens M, Hojjat SP, Whyne CM. Quantification of the effect of osteolytic metastases
on bone strain within whole vertebrae using imaging correlation. Journal of Orthopaedic Research
30(7): 1032-1039, 2012.
Hojjat SP, Beek M, Akens MK, Whyne CM. Can micro-imaging based analysis methods quantify
structural integrity of rat vertebrae with and without metastatic involvement? Journal of
Biomechanics 45(14): 2342-2348, 2012.
Hojjat SP, Wise-Milestone L, Foltz W, and Whyne CM. Muti-modal µCT / µMR based Semi-
Automated Segmentation of Rat Vertebra Affected by Mixed Osteolytic / Osteoblastic Metastases.
Medical Physics 39(5): 2848-2853, 2012.
Holt T, Hoskin P, Maranzano E, Sahgal A, Schild S, Ryu S, Loblaw A. Malignant epidural spinal
cord compression: the role of external beam radiotherapy. Current Opinion in Supportive and
Palliative Care 6:103-108, 2012.
Hyde D, Lochray F, Korol R, Davidson M, Wong CS, Ma L, Sahgal A. Spine stereotactic body
radiotherapy utilizing cone-beam CT image-guidance with a robotic couch: Intra-fraction motion
analysis accounting for all six degrees-of-freedom. International Journal of Radiation Oncology,
Biology and Physics 82(3): e555-562, 2012.
18
Jamani R, Dennis K, Jon F, Mingay A, Chen E, Nguyen J, Thavarajah N, Chow E. Long-term
survival in non-small cell lung carcinoma patients with brain metastases. Journal of Pain
Management 5(4): 349-353, 2012.
Khan L, Cramarossa G, Chen E, Nguyen J, Zhang L, Tsao M, Danjoux C, Barnes E, Sahgal A,
Holden L, Jon F, Culleton S, Chow E. Symptom clusters using the Edmonton Symptom
Assessment System in patients with bone metastases – a reanalysis comparing different
statistical methods. World Journal of Oncology 3(1): 23-32, 2012.
Khan L, Hugh S, Ansari S, Chiang A, Zeng L, Presutti R, Mitera G, Zhang L, Barnes E, Danjoux C,
Sahgal A, Chow E, Tsao M. Needs assessment of patients and their caregivers at the Rapid
Response Radiotherapy Program. Journal of Pain Management 5(2): 153-162, 2012.
Khan L, Kwong J, Nguyen J, Chow E, Zhang L, Culleton S, Zeng L, Jon F, Tsao M, Barnes E,
Danjoux C, Sahgal A, Holden L. Comparing baseline symptom severity and demographics over
two time periods in an outpatient palliative radiotherapy clinic. Supportive Care in Cancer 20(3):
549-555, 2012.
Koo K, Kwong J, Jon F, Zeng L, Dennis K, Holden L, Culleton S, Nguyen J, Khan L, Caissie A,
Chow E. A review of the impact of oxygen therapy in patients with advanced lung disease.
Journal of Pain Management 5(2): 119-130, 2012.
Koo K, Zeng L, Chen E, Culleton S, Dennis K, Zhang L, Caissie A, Nguyen J, Holden L, Jon F, Tsao
M, Barnes E, Danjoux C, Sahgal A, Chow E. Do elderly patients with metastatic cancer have
worse quality of life scores? Supportive Care in Cancer 20(9): 2121-2127, 2012.
Kurosaka S, Satoh T, Chow E, Asano Y, Tabata K, Kimura M, Tsumura H, Matsumoto K, Ishiyama
H, Inoue Y, Hayakawa K, Baba S. EORTC QLQ-BM22 and QLQ-C30 quality-of-life scores in
patients with painful bone metastases of prostate cancer treated with strontium-89 radionuclide
therapy. Annals of Nuclear Medicine 26(6): 485-461, 2012.
Leckie A, Akens MK, Woodhouse KA, Yee AJM, Whyne CM. Evaluation of thiol-modified
hyaluronan and elastin-like polypetide composite augmentation in early-stage disc degeneration
- comparing two minimally invasive techniques. Spine 37(20): E1296-1303, 2012.
Lemke M, Lien K, Zeng L, Popovic M, Zhou M, DiGiovanni J, Chow E. New considerations in the
design of clinical trials for bone metastases. World Journal of Oncology 3(1): 1-7, 2012.
Li W, Sahgal A, Foote M, Millar BA, Jaffray D, Letourneau D. Impact of immobilization on intra-
fraction motion for spine stereotactic body radiotherapy using cone-beam computed tomography.
International Journal of Radiation Oncology, Biology and Physics 84(2): 520-526, 2012
Lien K, Zeng L, Zhang L, Nguyen J, Di Giovanni J, Popovic M, Jamani R, Cramarossa G, Culleton
S, Chow E. Predictive factors for well-being in advanced cancer patients referred for palliative
radiotherapy. Clinical Oncology 24: 443-451, 2012.
Lightstone A, Tsao M, Basran PS, Chan G, Pang G, Ma L, Lochray F, Sahgal A. Cone beam CT
(CBCT) evaluation of inter- and intrafraction motion for patients undergoing brain radiotherapy
immobilized using a commercial thermoplastic mask on a robotic couch. Technology in Cancer
Research and Treatment 11(3): 203-209, 2012.
Liu R, Wong K, Yeung R, Khan L, Chow E, Merrick J. Palliative care in Hong Kong. Journal of Pain
Management 5(1): 3-4, 2012.
19
Lo SS, Sahgal A, Ma L, Chang EL. Advances in radiation therapy for brain metastases. Progress in
Neurological Surgery 25: 96-109, 2012.
Lo VCK, Akens MK, Moore S, Yee AJM, Wilson BC, Whyne CM. Beyond radiation therapy:
Photodynamic therapy maintains structural integrity of irradiated healthy and metastatically-
involved vertebrae. Breast Cancer Research and Treatment 135(2): 391-401, 2012.
Lutz S, Chow E. A Review of Recently Published Radiotherapy Treatment Guidelines for Bone
Metastases: Contrasts or Convergence? Journal of Bone Oncology 1(1):18-23, 2012.
Lutz S, Chow E. Palliative radiotherapy: The union of advanced technology with prudent end-of-
life care. Journal of Radiation Oncology 1(3): 199-200, 2012.
Ma L, Fogh S, Gupta N, Hwang A, Pinnaduwage D, Nakamura J, Barani I, McDermott M, Sneed
PK, Larson DA, Sahgal A. A technique for achieving submillimeter accuracy of volume-staged
stereotactic radiosurgery. Journal of Radiosurgery and SBRT 2(1): 11-17, 2012.
Ma L, Kirby N, Korol R, Larson DA, Sahgal A. Assessing small volume spinal cord doses for repeat
spinal stereotactic body radiotherapy treatments. Physics in Medicine Biology 57: 7843-7851,
2012.
Ma L, Sahgal A, Nie K, Hwang A, Karotki A, Wang B, Shrieve DS, Sned PK, McDermott M, Larson
DA. Reliability of contour-based volume calculation for radiosurgery. Journal of Neurosurgery
117: 203-210, 2012.
Maloul A, Regev E, Whyne CM, Beek M, Fialkov J. In vitro quantification of strain patterns in the
craniofacial skeleton due to masseter and temporalis activity. Journal of Craniofacial Surgery
23(5): 1529-1534, 2012.
Marchand EL, Sahgal A, Zhang TJ, Millar BA, Sharpe D, Moseley D, Letourneau D. Treatment
planning and delivery evaluation of volumetric modulated arc therapy of spinal tumours: impact
of arc discretization in planning system. Technology in Cancer Research and Treatment 11(6):
599-606, 2012.
Massicotte E, Foote M, Reddy R, Sahgal A. Minimal access spine surgery (MASS) for
decompression and stabilization performed as an out-patient procedure for metastatic spinal
tumours with epidural disease followed by stereotactic body radiotherapy (SBRT): First report of
technique and preliminary outcomes. Technology in Cancer Research and Treatment 11(1): 15-
25, 2012.
Masucci L, Masson-cote L, Letourneau D, Sahgal A. Grade 4 radiation induced colitis secondary to
conventional palliative radiation to a hip metastases. Journal of Palliative Medicine 15(3): 370-
372, 2012.
Mitera G, Zhang L, Sahgal A, Barnes E, Tsao M, Danjoux C, Holden L, Chow E. A survey of
expectations and understanding of palliative radiotherapy from patients with advanced cancer.
Clinical Oncology 24(2): 134-138, 2012.
Nam D, Mau E, Wang Y, Wright D, Silkstone D, Whetstone H, Whyne CM, Alman BA. T-
lymphoctyes Enable Osteoblast Maturation via IL-17F during the Early Phase of Fracture. PloS
ONE 7(6): e40044, 2012.
Nguyen J, Caissie A, Zhang L, Dennis K, Holden L, Jon F, Tsao M, Danjoux C, Barnes E, Sahgal A,
20
Chow E. Dexamethasone toxicity and quality of life in patients with brain metastases following
palliative whole brain radiotherapy. Journal of Radiation Oncology (published online April 28,
2012).
Nguyen J, Di Giovanni J, Zhang L, Popovic M, Jamani R, Cramarossa G, Culleton S, Jon F, Chow
E. Projected referral for health care services in an outpatient palliative radiotherapy clinic.
Expert Review of Pharmacoeconomics and Outcomes Research 12(2): 237-243, 2012.
Nguyen J, Zhang L, Clemons M, Vassiliou V, Danielson B, Fairchild A, Kerba M, Arnalot PF, Sahgal
A, Zeng L, Holden L, Tsao M, Danjoux C, Barnes E, Mingay A, Chow E. Content Validation of the
EORTC QLQ-BN20+2 with Patients and Health Care Professionals to Assess Quality of Life in
Brain Metastases. Journal of Radiation Oncology 1(4): 397-409, 2012.
Peleg E, Herblum R, Beek M, Joskowicz L, Liebergall M, Mosheiff R, Whyne CM. Can a partial
volume edge effect reduction algorithm improve the repeatability of subject specific finite
element models of bone obtained from CT data? Computer methods in biomechanics and
biomedical engineering (published online March 28, 2012).
Poon M, Zeng L, Zhang L, Popovic M, Chow R, Lam H, Bedard G, Emmenegger U, Simmons C,
Chow E. Skeletal morbidity rates over time in patients with bone metastases from solid tumors
reported in modifying agents randomised trials. Journal of Bone Oncology 1: 74-80, 2012.
Popovic M, Lemke M, Chen E, Nguyen J, Thavarajah N, DiGiovanni J, Caporusso F, Chow E.
Comparing Prognostic Factors in Patients with Spinal Metastases: A Literature Review. Expert
Review of Pharmacoeconomics and Outcomes Research 12(3): 345-356, 2012.
Popovic M, Nguyen J, Di Giovanni J, Chow E. Comparison of the EORTC QLQ-BM22 and the FACT-
BP for assessment of quality of life in cancer patients with bone metastases. Expert Review of
Pharmacoeconomics and Outcomes Research 12(2): 213-219, 2012.
Sahgal A, Ma L, Fowler J, Weinberg V, Gibbs I, Gerszten PC, Ryu S, Soltys S, Chang E, Wong CS,
Larson DA. Impact of dose hot spots on spinal cord tolerance following stereotactic body
radiotherapy: a generalized biologically effective dose analysis. Technology in Cancer Research
and Treatment 11(1): 35-40, 2012.
Sahgal A, Ma L, Weinberg V, Gibbs IC, Chao S, Chang U, Werner-wasik M, Angelov A, Chang EL,
Sohn MJ, Soltys S., Letourneau D, Ryu S, Gerszten PC, Fowler J, Wong CS, Larson DA. Re-
treatment spinal cord tolerance for spine stereotactic body radiotherapy. International Journal of
Radiation Oncology, Biology and Physics 82(1): 107-116, 2012.
Sahgal A, Roberge D, Schellenberg, D, Purdie TG, Swaminath A, Pantarotto J, Filion E, Gabos Z,
Butler J, Letourneau D, Masucci GL, Mulroy L, Bezjak A, Dawson LA, Parliament M. The Canadian
Association of Radiation Oncology (CARO) scope of practice guidelines for lung, liver and spine
stereotactic body radiotherapy (SBRT). Clinical Oncology 24(9):629-639, 2012.
Sahgal A, Soliman S, Larson DA. Whole brain radiation therapy for brain metastases. Progress in
Neurological Surgery 25: 82-95, 2012.
Sahgal A, Weinberg V, Ma L, Chang E, Chao S, Muacevic A, Gorgulho A, Soltys S, Gerszten P.C.,
Ryu S, Angelov A, Gibbs I, Wong S, Larson DA. Probabilities of radiation myelopathy specific to
stereotactic body radiotherapy to guide safe practice. International Journal of Radiation
Oncology, Biology and Physics (published online June 17, 2012).
Sahgal A. Current status and the future of spine radiosurgery. The Spine journal 1(5):1-2, 2012.
21
Sahgal A. Technologic advances in brain and spine radiosurgery. Technology in Cancer Research
and Treatment 11(1): 1-2, 2012.
Salo Z, Beek M, Whyne CM. Evaluation of mesh Morphing and mapping techniques in patient
specific modeling of the human pelvis. International Journal of Numerical Methods in Biomedical
Engineering 28(8): 904–913, 2012.
Salvo N, Zhang L, Leung M, Khan L, Presutti R, Nguyen J, Holden L, Culleton S, Zeng L, Chow E.
Frequency of reporting and predictive factors for anxiety and depression in patients with
advanced cancer. Clinical Oncology 24(2): 139-148, 2012.
Souza N, Holden L, Robson S, Mah K, Di Prospero L, Wong CS, Chow E, Spayne J. Modern
palliative radiation treatment: do complexity and workload contribute to medical errors?
International Journal of Radiation Oncology, Biology and Physics 84(1): e43-e48, 2012.
Thavarajah N, Chen E, Bedard G, Lauzon N, Zhou M, Chu D, Chow E. Symptom clusters in
patients with prostate cancer: a literature review. Journal of Pain Management 5(4): 303-310,
2012.
Thavarajah N, Chen E, Zeng L, Bedard G, Di Giovanni J, Lemke M, Lauzon N, Zhou M, Chu D,
Chow E. Symptom clusters in patients with metastatic cancer: a literature review. Expert Review
of Pharmacoeconomics & Outcomes Research 12(5): 597-604, 2012.
Tsao M, Xu W, Sahgal A. A meta-analysis evaluating stereotactic radiosurgery, whole brain
radiotherapy, or both for patients presenting with a limited number of brain metastases. Cancer
118(9): 2486-2493, 2012.
Wise-Milestone L and Whyne CM. Local Treatment of Mixed Osteolytic/Osteoblastic Spinal
Metastases: Is Photodynamic Therapy Effective? Breast Cancer Research and Treatment 133(3):
899-908, 2012.
Wright D, Meguid M, Lubovsky O, Whyne CM. Subchondral bone distribution in the healthy
human femoral head. Skeletal Radiology 41(6): 677-683, 2012.
Wright D, Nam D and Whyne CM. A comparison of stereology, structural rigidity and a novel
measure of 3D bone connectivity in the assessment of torsional strength and stiffness in a mouse
tibia fracture model. Journal of Biomechanics 45(13): 2236-2240, 2012.
Zeng L, Chow E, Bedard G, Zhang L, Fairchild A, Vassiliou V, Alm El-Din M, Jesus-Garcia R,
Kumar A, Forges F, Tseng L, Hou M, Chie W, Bottomley A. Quality of life after palliative
radiotherapy for patients with painful bone metastases: Results of an international study
validating the EORTC QLQ-BM22. International Journal of Radiation Oncology, Biology and
Physics 84(3): e337-e342, 2012.
Zeng L, Chow E, Zhang L, Culleton S, Holden L, Jon F, Khan L, Tsao, Barnes E, Danjoux C,
Sahgal A. Comparison of pain response and functional interference outcomes between spinal and
non-spinal bone metastases treated with palliative radiotherapy. Supportive Care in Cancer
20(3): 633-639, 2012.
Zeng L, Chow E, Zhang L, Tseng L, Hou M, Fairchild A, Vassiliou V, Jesus-Garcia R, Alm El-Din
MA, Kumar A, Forges F, Chie W, Bedard G, Bottomley A. An international prospective study
establishing minimal clinically important differences in the EORTC QLQ-BM22 and QLQ-C30 in
cancer patients with bone metastases. Supportive Care in Cancer 20(12): 3307-3313, 2012.
22
Zeng L, Chow E. The added challenges of bone metastases treatment in elderly patients. Clinical
Oncology (published online November 27, 2012) DOI information: 10.1016/j.clon.2012.11.001.
Zeng L, Koo K, Zhang L, Jon F, Dennis K, Holden L, Nguyen J, Tsao M, Barnes E, Danjoux C,
Sahgal A, Chow E. Fatigue in advanced cancer patients attending an outpatient palliative
radiotherapy clinic as screened by the Edmonton Symptom Assessment System. Supportive Care
in Cancer 20(5): 1037-1042, 2012.
Zeng L, Lutz S, Chow E, Hoskin P. Recent important developments in the management of non-
spine bone metastases. Current Opinion in Supportive and Palliative Care 6 (1): 80-84, 2012.
Zhou M, Zeng L, Christakis M, Poon M, Chen E, Lauzon N, Thavarajah N, DiGiovanni J, Chow E.
Unusual presentation of osteolytic bone metastases in prostate adenocarcinoma. Journal of Pain
Management 5(4): 365-367, 2012.
23
In Press Al-Omair A, Smith R, Kiel T, Lao L, Yu E, Massicotte EM, Keith J, Fehlings MG, Sahgal A.
Radiation-induced vertebral compression fracture following spine radiosurgery: Clinical-
pathological correlation. Journal of Neurosurgery: Spine.
Axelrod D, Lubovsky O, Safran O, Axelrod T and Whyne CM. Fractures of the clavicle; which x-
ray projection provides the greatest accuracy in determining displacement of the fragments?
Journal of Orthopaedics and Trauma.
Bedard G, Zeng L, Lam H, Lauzon N, Hicks K, Chow E. Positron emission tomography and bone
metastases – A review of the literature. Journal of Pain Management.
Bedard G, Zeng L, Lauzon N, Probyn L, Dennis K, Chow E. Heterotopic ossification: Mimics of
other benign and malignant etiologies. Journal of Pain Management.
Bedard G, Zeng L, Poon M, Lam H, Lauzon N, Chow E. Comparison of the EORTC QLQ-BM22 and
the BOMET-QOL Quality of Life Questionnaires in Patients with Bone Metastases. Asia Pacific
Journal of Clinical Oncology.
Bedard G, Zeng L, Verma S, Lauzon N, Holden L, Dennis K, Poon M, Chow E. Osteonecrosis of
the jaw appearing as bone metastases in bone scan in a patient breast cancer. Journal of Pain
Management.
Bedard G, Zeng L, Zhang L, Lauzon N, Holden L, Tsao M, Danjoux C, Barnes E, Sahgal A, Poon
M, Chow E. Minimal clinically important differences in the Edmonton Symptom Assessment
System in patients with advanced cancer. Journal of Pain and Symptom Management.
Bedard G, Zeng L, Zhang L, Lauzon N, Holden L, Tsao M, Danjoux C, Barnes E, Sahgal A, Poon
M, Hicks K, Chow E. Minimal clinically important differences in the EORTC QLQ-C15-PAL to
determine meaningful change for patients with advanced cancer. Asia Pacific Journal of Clinical
Oncology.
Chiu N, Chiu L, Zeng L, Zhang L, Cella D, Beaumont J, Popovic M, Chow R, Lam H, Poon M, Chow
E. Quality of life in patients with primary and metastatic brain tumors in the literature as
assessed by the FACT-Br. World Journal of Oncology.
Chu D, Nguyen J, Koo K, Zeng L, Bedard G, Lam H, Wong E, Popovic M, Chow E. An update on
the quality of life measurements in lung cancer patients receiving palliative radiotherapy: a
literature review. World Journal of Oncology.
Cramarossa G, Chen E, Zeng L, Danjoux C, Higgins K, Phan N, Aviv R, Lauzon N, Dennis K, Chow
E. Prophylaxis with radiation treatment after surgery to the cervical spine for established
heterotopic ossification. Journal of Pain Management.
Crookshank M, Beek M, Singh D, Schemitsch E, Whyne CM. Can a semi-automated surface
matching and principal axis-based algorithm accurately quantify femoral shaft fracture alignment
in six degree of freedom? Medical Engineering & Physics.
Dennis K, Makhani L, Zeng L, Lam H, Chow E. Single fraction conventional external beam
radiation therapy for bone metastases: a systematic review of randomised controlled trials.
Radiotherapy and Oncology.
24
Fandiño M, Macdonald KI, Singh D, Whyne CM, Witterick IJ. Determining the best graft-sealant
combination for CSF leak repair using an in vitro porcine model. International forum of allergy
and rhinology.
Gorapalli D, Seth A, Vournakis J, Whyne CM, Akens M, Zhang A, Demcheva M, Qamirani E, Yee
AJM. Evaluation of a novel poly N-acetyl glucosamine (pGlcNAc) hydrogel for treatment of the
degenerating intervertebral disc. Life Sciences.
Jamani R, Dennis K, Jon F, Mingay A, Chen E, Nguyen J, Thavarajah N, Chow E. Long-term
survival in non-small cell lung carcinoma patients with brain metastases. Journal of Pain
Management.
Jamani R, Zeng L, Probyn L, Lauzon N, Holden L, Thavarajah N, Wong E, Chow E. Pain relief
through palliative radiation therapy in a patient with cervical spine bone metastases. Journal of
Pain Management.
Khan L, Zeng L, Cella D, Thavarajah N, Chen E, Zhang L, Bennett M, Peckham K, De Costa S,
Beaumont J, Tsao M, Danjoux C, Barnes E, Sahgal A, Chow E. Patients‘ and health care
providers‘ evaluation of quality of life issues in advanced cancer using Functional Assessment of
Chronic Illness therapy – Palliative care module (FACIT-Pal) scale. World Journal of Oncology.
Koo K, Kerba M, Zeng L, Zhang L, Chen E, Chow E, Sahgal A. Quality of life in patients with brain
metastases receiving upfront as compared to salvage stereotactic radiosurgery using the EORTC
QLQ-C15-PAL and the EORTC QLQ BN20+2: A pilot study. Journal of Radiation Oncology.
Koo K, Zeng L, Zhang L, DasGupta T, Vachon MLS, Holden L, Jon F, Chow E, Di Prospero L.
Comparison and literature review of occupational stress in a palliative radiotherapy clinic‘s
interprofessional team, the radiation therapists and the nurses at an academic cancer centre.
Journal of Medical Imaging and Radiation Sciences.
Lam K, Zeng L, Zhang L, Tseng L, Hou M, Fairchild A, Vassiliou V, Jesus-Garcia R, Alm El-Din M,
Kumar A, Forges F, Chie W, Sahgal A, Poon M, Chow E. Predictive factors of overall well-being
using the EORTC QLQ-C15-Pal extracted from EORTC QLQ-C30. Journal of Palliative Medicine.
Lao N, Poon M, Probyn L, Popovic M, Chow R, Lauzon N, Chow E. Single fraction palliative
radiation treatment in the treatment of bone metastases with soft tissue mass. Journal of Pain
Management.
Lauzon N, Bedard G, Zhang L, Sahgal A, Zeng L, Koo K, Chow E. Health care professionals‘
evaluation of quality of life issues in patients with brain metastases. World Journal of Oncology.
Maloul A, Fialkov J, Whyne CM. Characterization of the Bending Strength of Craniofacial Sutures.
Journal of Biomechanics.
Mok F, Li K, Yeung R, Wong K, Yu B, Wong E, Bedard G, Chow E. ‗Who‘, ‗When‘ and ‗How‘ in re-
irradiation of recurrent painful bone metastases. Journal of Bone Oncology.
Nguyen J, Chu D, Bedard G, Wong E, Jon F, Danjoux C, Barnes E, Tsao M, Holden L, Chow E,
Lauzon N. Palliative radiotherapy in the treatment of lung metastases or advanced cancer.
Journal of Pain Management.
Pakdel A, Robert N, Fialkov J, Maloul A, Whyne CM. Generalized method for computation of true
thickness and x-ray intensity information in highly blurred sub-millimeter bone features in clinical
CT images. Physics in Medicine and Biology.
25
Poon M, Chen E, Probyn L, Zeng L, Lauzon N, Holden L, Chow E. Asymptomatic presentation of
lung and bone metastases in a patient with breast cancer. Journal of Pain Management.
Poon M, Ford M, Zeng L, Christakis M, Sinclair E, Lauzon N, Popovic M, Chow E. Good surgical
outcome and long survival in a patient with occipitocervical instability requiring occiput to C3
fixation. Journal of Pain Management.
Poon M, Zeng L, Zhang L, Tseng L, Hou M, Fairchild A, Vassiliou V, Jesus-Garcia R, Alm El-Din M,
Kumar A, Forges F, Chie W, Sahgal A, Wong E, Chow E. Comparison of baseline quality of life
scores in patients with bone and brain metastases as assessed using the EORTC QLQ-C30.
Journal of Pain Management.
Popovic M, Prica M, Minic M, Steele B, Chow E, Popovic J. Needs assessment of medical care for
rural Jamaicans that require assistance from short-term medical missions. International Public
Health Journal.
Slaven M, Spencer F, Chow E. Barriers to prescription of sublingual Fentanyl tablets for
breakthrough cancer pain in an outpatient cancer center. Journal of Pain Management.
Szwedowski TD, Fialkov J, Pakdel A and Whyne CM. Technical Report: An Optimized Process Flow
for Rapid Segmentation of Cortical Bones of the Craniofacial Skeleton using the Level-Set
Method. Dental maxillofacial Radiology - A Journal of Head and Neck Imaging.
Thavarajah N, Chen E, Bedard G, Lauzon N, Zhou M, Chu D, Chow E. Symptom clusters in
patients with prostate cancer: a literature review. Journal of Pain Management.
Thavarajah N, Wong K, Zhang L, Bedard G, Wong E, Tsao M, Danjoux C, Barnes E, Sahgal A,
Dennis K, Holden L, Lauzon N, Chow E. Continued success in providing timely palliative radiation
therapy at the Rapid Response Radiotherapy Program: A Review of 2008-2012. Current
Oncology.
Wong E, Bedard G, Probyn L, Pulenzas N, Lechner B, Holden L, Chow E, Lauzon N. Focal myositis
as a presentation of paraneoplastic syndrome in pancreatic cancer. Journal of Pain Management.
Wong E, Cramarossa G, Bedard G, Probyn L, Holden L, Chow E, Lauzon N. Radiation therapy
alone for established heterotopic ossification. Journal of Pain Management.
Wong K, Zeng L, Zhang L, Bedard G, Wong E, Tsao M, Barnes E, Danjoux C, Sahgal A, Holden L,
Lauzon N, Chow E. Minimal clinically important differences in the brief pain inventory in patients
with bone metastases. Supportive Care in Cancer.
Zeng L, Bedard G, Cella D, Thavarajah N, Chen E, Zhang L, Bennett M, Peckham K, De Costa S,
Beaumont J, Tsao M, Danjoux C, Barnes E, Sahgal A, Chow E. Preliminary results of the
generation of a shortened quality of life assessment for patients with advanced cancer: the
FACIT-Pal-14. Journal of Bone Oncology.
Zhou M, Holden L, Bedard G, Zeng L, Lam H, Chu D, Lao N, Lauzon N, Chow E. The utilization of
telephone follow-up in the advanced cancer population: A review of the literature. Journal of
Comparative Effectiveness Research.
Zhou M, Zeng L, Christakis M, Poon M, Chen E, Lauzon N, Thavarajah N, DiGiovanni J, Chow E.
Unusual presentation of osteolytic bone metastases in prostate adenocarcinoma. Journal of Pain
Management.
26
Books, Book Chapters
Bedi H, Kwong J, Chow E. Metastatic cancer: Symptom cluster and gender differences.
Alternative Medicine Yearbook 2010. Chapter 35 Pages 471-485. Editor: Joav Merrick. Nova
Science Publishers, Inc. 2012.
Chan E, Emmenegger U. Bisphosphonates for bone metastases. Future Medicine e-Book Series,
Advances in Bone Metastasis Management. Pages 66-79, 2012.
Chow E, Khan L, Bruland O. Radiotherapy of skeletal metastases. ASBMR Primer 8th edition of
the primer on the metabolic bone diseases and disorders of mineral metabolism. Society for Bone
and Mineral Research (in press).
Di Giovanni J, Nguyen J, Popovic M, Chow E. Radiotherapy for bone metastases. E-book. Bone
Metastases Management. Pages 2-9. Editors: Piero Picci, Pietro Ruggieri. Future Science Group
(in press).
Lo SS, Sahgal A, Kunos C, Teh BS, Yao M, Machtay M, Chang EL. Normal tissue constraints.
Stereotactic Body Radiotherapy. Pages 393-401. Editors: Lo SS, Teh BS, Lu JJ, Schefter T.
Springer, 2012.
Lo SS, Sahgal A, Kunos C, Teh BS, Yao M, Machtay M, Chang EL. Repoted toxicities associated
with stereotactic body radiotherapy. Stereotactic Body Radiotherapy. Pages 373-392. Editors: Lo
SS, Teh BS, Lu JJ, Schefter T. Springer, 2012.
Lo SS, Sloan AE, Machtay M, Teh BS, Sahgal A, Chao ST, Chang EL. Spinal Metastases.
Stereotactic Body Radiotherapy. Pages 355-372. Editors: Lo SS, Teh BS, Lu JJ, Schefter T.
Springer, 2012.
Lutz S, Chow E. Palliative radiation therapy. Clinical Radiation Oncology. Editor: William Small.
(in press).
Nguyen J, Hayter C, Wong R, Danjoux C, Holden L. A survey to assess patient awareness and
interest in hypnosis for cancer pain and distressing procedures. Alternative Medicine Yearbook
2010. Chapter 8 Pages 97-112. Editor: Joav Merrick. Nova Science Publishers, Inc. 2012.
Nguyen J, Sahgal A, Chow E, Danielson B. Brain metastases and quality of life. Alternative
Medicine Yearbook 2010. Chapter 33 Pages 435-455. Editor: Joav Merrick. Nova Science
Publishers, Inc. 2012.
Pang J, Panzarella T, Chow E. Prognosis and survival prediction. Alternative Medicine Yearbook
2010. Chapter 37 Pages 503-530. Editor: Joav Merrick. Nova Science Publishers, Inc. 2012.
27
Posters, Presentations and Published Abstracts
2012 Annual Hospice Palliative Care Ontario Conference. Toronto, Ontario, Canada,
April 29 – May 1, 2012.
Thavarajah N, Chen E, Holden L, Jon F, Chow E, Di Prospero L. Pain Management Needs
Assessment Survey for Radiation Therapists at an Academic Cancer Centre.
Zhou M, Lien K, Zeng L, Zhang L, Nguyen J, Di Giovanni J, Popovic M, Jamani R,
Cramarossa G, Culleton S, Chow E. Predictive Factors for Well-Being in Advanced Cancer
Patients Referred for Palliative Radiotherapy.
Zhou M, Nguyen J, Caissie A, Zhang L, Dennis K, Holden L, Jon F, Tsao M, Danjoux C,
Barnes E, Sahgal A, Chow E. Dexamethasone Side Effects and Quality of Life in Patients
with Brain Metastases Following Palliative Whole Brain Radiotherapy.
American Society of Therapeutic Radiation Oncology. Boston, Massachusetts, USA,
October 28 – 31, 2012.
Alomair A, Cunha M, Atenafu E, Letourneau D, Korol R, Yu E, Masucci L, Da Costa L,
Fehlings M, Sahgal A. The risk of vertebral compression (VCF) post-spine stereotactic
body radiotherapy (SBRT) and evaluation of the spinal instability neoplastic score
(SINS). International Journal of Radiation Oncology, Biology and Physics 84(3S): S39,
2012.
Chiang A, Zeng L, Koo K, Chow E, Lochray F, Masucci L, Korol R, Sahgal A. The
incidence of pain flare following stereotactic body radiotherapy for bone metastases.
International Journal of Radiation Oncology, Biology and Physics 84(3S): S209, 2012.
Gerszten PC, Kersh R, Sweeney RA, Sahgal A, Sheehan JG, Flickinger JC, Fahim DK,
Grills IS, Guckenberger M. A multinational report on methods for institutional
credentialing for spine radiosurgery. International Journal of Radiation Oncology, Biology
and Physics 84(3S): S286, 2012.
Guckenberger M, Sweeney RA, Flickinger J, Grills I, Tyagi N. Sahgal A, Letourneau D,
Sheehan J, Schlesinger D, Gerszten PC. Variability in spine radiosurgery planning-
Results on a multi-institutional study. International Journal of Radiation Oncology,
Biology and Physics 84(3S): S195, 2012.
Huang Z, Mayr NA, Yuh WT, Sahgal A, Wang JZ, Lo SS. Reirradiation with stereotactic
body radiotherapy (SBRT): Analysis of human spinal cord tolerance using the
generalized linear quadratic model. International Journal of Radiation Oncology, Biology
and Physics 84(3S): S280, 2012.
Soliman H, Al-Omair A, Xu W, Karotki A, Phan N, Das S, Perry J, Tsao M, Mainprize T,
Sahgal A. Outcomes for post-surgical hypofractionated stereotactic cavity radiation
therapy (HSCRT) as salvage for patients with prior whole brain radiation (WBRT) as
compared to upfront adjuvant HSCRT. International Journal of Radiation Oncology,
Biology and Physics 84(3S): S303-304, 2012.
Tseng E, Sussman M, Simeonov A, Letourneau D, Yu E, Sahgal A. Spinal cord motion
considerations for stereotactic body radiotherapy: Does the cord move? International
Journal of Radiation Oncology, Biology and Physics 84(3S): S279, 2012.
Canadian Association of Radiation Oncologists Annual Scientific Meeting. Ottawa,
Ontario, Canada, September 12 –15, 2012.
Alomair A, Soliman H, Xu W, Karotki A, Phan N, Das S, Perry J, Tsao M, Mainprize M,
Sahgal A. Outcomes for post-surgical hypofractionated stereotactic cavity radiotherapy
(HSCRT) as salvage for patients with prior whole brain radiotherapy (WBRT) as
compared to upfront adjuvant HSCRT. Radiotherapy and Oncology 104(2): S21, 2012.
Alomair A, Soliman H, Xu W, Karotki A, Phan N, Das S, Perry J, Tsao M, Mainprize M,
Sahgal A. Outcomes for post-surgical hypofractionated stereotactic cavity
28
radiotherapy (HSCRT) as salvage for patients with prior whole brain radiotherapy
(WBRT) as compared to upfront adjuvant HSCRT. Radiotherapy and Oncology 104(2):
S21, 2012.
Chiang A, Zeng L, Koo K, Chow E, Lochray F, Masucci L, Korol R, Sahgal A. Incidence of
pain flare following stereotactic body radiotherapy for bone metastases. Radiotherapy
and Oncology 104(2): S22, 2012.
Khan L, Zeng L, Chow E, Zhang L. Minimal Clinically Important Differences in the EORTC
QLQ-BM22 and QLQ-C30 in Cancer Patients with Bone Metastases.
Masucci GL, Wong R, Brundage M, Stanton H, Wilson C, Meyer R, Sahgal A. Developing
the NCIC-CTG SC 24 randomized phase II spine SBRT (Stereotactic Body Radiotherapy)
study for complex spinal metastases: What should the control group be? Radiotherapy
and Oncology 104(2): S24, 2012.
Sahgal A, Roberge D, Schellenberg D, Purdie T, Swaminath A, Pantarotto J, Filion E,
Gabos Z, Butler J, Letourneau D, Masucci L, Mulroy L, Bezjak A, Dawson L, Parliament
M. Lung, liver, and spine stereotactic body radiotherapy (SBRT): Canadian Association of
Radiation Oncology (CARO) scope of guidelines. Radiotherapy and Oncology 104(2):
S60, 2012.
Sahgal A, Roberge D, Schellenberg D, Purdie T, Swaminath A, Pantarotto J, Filion E,
Gabos Z, Butler J, Letourneau D, Masucci L, Mulroy L, Bezjak A, Dawson L, Parliament
M. Lung, liver, and spine stereotactic body radiotherapy (SBRT): Canadian Association of
Radiation Oncology (CARO) scope of guidelines.
Sahgal A, Weinberg V, Ma L, Chang E, Chao S, Muacevic A, Gorgulho A, Gibbs I, Soltys
S, Gerszten P, Angelov L, Wong S, Larson D. Probabilities of radiation myelopathy
specific to stereotactic body radiotherapy to guide safe practice. Radiotherapy and
Oncology 104(2): S24, 2012.
Sahgal A, Weinberg V, Ma L, Chang E, Chao S, Muacevic A, Gorgulho A, Gibbs I, Soltys
S, Gerszten P, Angelov L, Wong S, Larson D. Probabilities of radiation myelopathy
specific to stereotactic body radiotherapy to guide safe practice.
Sinclair E, Lau M. Establishing a Place for an Advanced Practice Radiation Therapist in
Palliative Radiation Therapy: Experiences of Two Urban Cancer Centres.
Tseng CL, Sussman M, Simeonov A, Letourneau D, Yu E, Sahgal A. Spinal cord motion
considerations for spine stereotactic body radiotherapy (SBRT): Does the cord move?
Radiotherapy and Oncology 104(2):S24, 2012.
Inaugural Joint University of Toronto and China Symposium: Current Concepts in
Spinal and Musculoskeletal Oncology. Toronto, Ontario, October 5, 2012.
Chow E. Quality of Life in Bone Metastases.
Czarnota G. HIFU Bone Metastases.
DeAngelis C, Pasetka M. Urinary Markers for Pain Flare and HIFU Bone Metastases.
Emmenegger U. Latest Advances in the Medical Treatment of Bone Metastases.
Finkelstein J. Population Based Outcomes in Spinal Metastases.
Holden L. Multidisciplinary Bone Metastases Clinic at Odette Cancer Centre, First of its
Kind in Canada.
Sahgal A. Stereotactic Radiosurgery of Spinal Metastases.
Sinclair E, Ford M, Danjoux C, Chow E. Minimally Invasive Treatment of Tumour Related
Vertebral Compression Fractures and Other Metastatic Bone Lesions.
Whyne C. Evaluating Stability in the Vertebral Metastatic Spine – Effects of Systemic and
Local Therapies.
Yee A. Anterior Sacrectomy for Locally Recurrent Rectal Carcinoma - Role and Technical
Considerations for Wide Tumour Resection.
MASCC/ISOO International Symposium on Supportive Care in Cancer. New York
City, USA, June 28 – 30, 2012.
Chu D, Nguyen J, Zhang L, Clemons M, Vassiliou V, Danielson B, Fairchild A, Kerba M,
29
Arnalot PF, Sahgal A, Zeng L, Holden L, Tsao M, Danjoux C, Barnes E, Chow E. Content
Validation of the EORTC QLQ-BN20+2 by Patients and Health Care Professionals to
Assess Quality of Life in Brain Metastases.
Cramarossa G, Chen E, Zhang L, Zeng L, Chow E. Predictive Factors for Overall Quality
of Life in Advanced Cancer Patients from EORTC QLQ C30.
Cramarossa G, Chen E, Zhang L, Zeng L, Chow E. Predictive Factors for Overall Quality
of Life in Advanced Cancer Patients from EORTC QLQ-Pal-15.
De Angelis C, Pasetka M, Dennis K, Hird A, Chow E. A Pilot Study to Evaluate Urinary
Cytokines/Chemokines as Markers of Pain Flare in Patients Undergoing External Beam
Radiotherapy for the Treatment of Painful Bone Metastases.
Di Giovanni J, Zeng L, Zhang L, Cella D, Sahgal A, Chang E, Chen E, Thavarajah N,
Beaumont J, Bennett M, De Costa S, Nguyen J, Chow E. Content Validation of the FACT-
Br in Patients and Healthcare Professionals to Assess Quality of Life in Brain Metastases.
Di Prospero L, Holden L, Chow E. Pain Management Needs Assessment: A Survey of
Radiation Therapists at a Large Academic Comprehensive Cancer Center.
Hawley P, Zeng L, Zhang L, Slaven M, Gagnon P, Chen E, Thavarajah N, Bennett M, De
Costa S, Chow E. Characteristics and Treatment of Breakthrough Pain in Canadian
Cancer Patients.
Jamani R, Bedard G, Nguyen J, Di Giovanni J, Chen E, Zhang L, Popovic M, Cramarossa
G, Culleton S, Jon F, Chow E. Projected Referral for Health Care Services in an
Outpatient Palliative Radiotherapy Clinic.
Jamani R, Dennis K, Jon F, Chow E. Long-term Survival in Patients with Brain Metastases
from Non-small Cell Lung Carcinoma: a Case Series.
Khan L, Zeng L, Zhang L, Cella D, Thavarajah N, Chen E, Bennett M, De Costa S, Chow
E. Health Care Professional Perspectives on Quality of Life Issues Most Important to
Patients with Brain Metastases.
Khan L, Zeng L, Zhang L, Cella D, Thavarajah N, Chen E, Bennett M, De Costa S, Chow
E. A Comparison of Health Care Provider versus Patient Perspectives on the FACIT-Pal.
Koo K, Zeng L, Sahgal A, Chow E. Quality of Life of Brain Metastases Patients Receiving
Stereotactic Radiosurgery using the EORTC QLQ-C15-PAL and the EORTC QLQ BN20+2.
Koo K, Zeng L, Zhang L, DasGupta T, Vachon MLS, Holden L, Jon F, Chow E, Di Prospero
L. Comparison of Occupational Stress in a Palliative Radiotherapy Clinic's
Interprofessional Team, the Radiation Therapists and the Nurses at an Academic Cancer
Centre.
Leung AB, Chen E, Nguyen J, Zhang L, Zeng L, Holden L, Lauzon N, Bedard G, Koo K,
Danjoux C, Sahgal A, Tsao M, Barnes E, Chow E. Quality of Life in Patients with Brain
Metastases using the EORTC QLQ-BN20 and QLQ-C30.
Popovic M, Lemke M, Chen E, Nguyen J, Thavarajah N, Di Giovanni J, Caporusso F, Chow
E. Comparing Prognostic Factors in Patients with Spinal Metastases.
Popovic M, Nguyen J, Chen E, Di Giovanni, Chow E. Comparison of the EORTC QLQ-
BM22 and the FACT-BP for the Assessment of Quality of Life in Cancer Patients with
Bone Metastases.
Zeng L, Bedard G, Lam H, Cella D, Zhang L, Lauzon N, Chow E. Meaningful Change in
Oncology Quality of Life Instruments: a Literature Review.
Zeng L, Koo K, Chow E, Lochray F, Masucci L, Korol R, Sahgal A. Pain Flare after
Stereotactic Body Radiotherapy for Bone Metastases.
Zeng L, Zhang L, Tseng L-M, Hou M-F, Fairchild A, Vassiliou V, Jesus-Garcia R, Alm El-
Din MA, Kumar A, Forges F, Chie WC, Bedard G, Chow E. An International Prospective
Study Establishing Minimal Clinically Important Differences in the EORTC QLQ-BM22 and
QLQ-C30 in Cancer Patients with Bone Metastases.
Zeng L, Zhang L, Fairchild A, Vassiliou V, Alm El-Din M, Jesus-Garcia R, Kumar A,
Forges F, Chow E. Comparison of Quality of Life in Patients with Bone Metastases
Depending on Response to Palliative Radiotherapy.
Zhou M, Zeng L, Zhang L, Cella D, Beaumont J, Yanez B, Thavarajah N, Chen E, Bennett
M, De Costa S, Chow E. Development of a Shortened FACIT-Pal for Patients with
Advanced Cancer.
30
Toronto Cancer Conference. Toronto, Ontario, Canada, November 22 – 23, 2012.
Bedard G, Ray S, Zhang L, Zeng L, Cella D, Wong E, Danjoux C, Tsao M, Barnes E,
Sahgal A, Holden L, Lauzon N, Chow E. Content Validation of the Brain Symptom and
Impact Questionnaire (BASIQ) with Patients and Health-care Professionals to Assess
Quality of Life in Patients with Brain Metastases.
Bedard G, Zeng L, Lam H, Cella D, Zhang L, Lauzon N, Chow E. Meaningful Change in
Oncology Quality-of-Life Instruments: A Systematic Literature Review.
Bedard G, Zeng L, Zhang L, Lauzon N, Holden L, Tsao M, Danjoux C, Barnes E, Sahgal
A, Poon M, Chow E. Minimal Clinically Important Differences in the Edmonton Symptom
Assessment System in Patients with Advanced Cancer.
Bedard G, Zhang L, Slaven M, Gagnon P, Bisland S, Bennett M, Chow E, Hawley P. A
Survey of Canadian Cancer Patients‘ Perspectives on the Characteristics and Treatment
of Breakthrough Pain.
Lauzon N, Cramarossa G, Chen E, Zhang L, Zeng L, Chow E. Predictive Factors for
Overall Quality of Life in Advanced Cancer Patients from EORTC QLQ-Pal-15.
Lauzon N, Zeng L, Chow E, Bedard G, Zhang L, Fairchild A, Vassiliou V, Alm El-Din MA,
Jesus-Garcia R, Kumar A, Forges F, Tseng LM, Hou M, Chie W, Bottomley A. Quality of
Life After Palliative Radiotherapy for Patients with Painful Bone Metastases: Results of
an International Study Validating the EORTC QLQ-BM22.
Popovic M, Lao N, Zeng L, Zhang L, Cella D, Beaumont J, Chow R, Chiu N, Chiu L, Lam
H, Poon M, Chow E. The Impact of Clinical and Socio-demographic Features on Quality of
Life in Patients with Early Stage Cancers using the Functional Assessment of Cancer
Therapy-General Assessment Tool.
Popovic M, Nguyen J, Chen E, Di Giovanni J, Chow E. Comparison of the EORTC QLQ-
BM22 and the FACT-BP for Assessment of Quality of Life in Cancer Patients with Bone
Metastases.
Rodin D, Dennis K, Coccagna J, Chow E, Hynynen K, Czarnota G. Magnetic Resonance-
guided High-intensity Focused Ultrasound for the Palliative of Painful Skeletal
Metastases: A Pilot Study.
Wong E, Bedard G, Chen E, Nguyen J, Zhang L, Zeng L, Holden L, Lauzon N, Koo K,
Mingay A, Danjoux C, Sahgal A, Tsao M, Barnes E, Chow E. Quality of Life in Patients
with Brain Metastases using the EORTC QLQ-BN20 and QLQ-C30.
Wong E, Chen E, Cella D, Zeng L, Thavarajah N, Zhang L, Chang E, Sahgal A, Bennett
M, Peckham K, De Costa S, Beaumont J, Tsao M, Danjoux C, Barnes E, Chow E. Content
Validation of the FACT-Br in Patients and Health-care Professionals to Assess Quality of
Life in Brain Metastases.
31
Abstracts, Poster and Peer-reviewed Presentations
Akens M, Wright D, Yousef S, Nam D, Yee A, Wilson B, Whyne CM. The Effect of Photodynamic
Therapy (PDT) on Long Bone Fracture Healing. Orthopaedic Research Society, 2012 Annual
Meeting. San Francisco, California, USA, February 4-7, 2012.
Akens MK, Wright D, Yousef S, Nam D, Yee A, Wilson BC, Whyne CM. The Effect of Photodynamic
Therapy (PDT) on Long Bone Fracture. Canadian Orthopaedic Research Society, 46th Annual
Meeting. Ottawa, Ontario, June 8–10, 2012.
Chan M, Bartlett E, Kucharczyk W, Sahgal A, Curtin H, Yu E. North American Skull Base Meeting.
Las Vegas, Nevada, USA. Journal of Neurological Surgery (73): A-248, 2012.
Chow E. Bone Metastases Palliative Radiotherapy---Obstacles and Challenges. Association of
Italian Radiation Oncologists 2012 Annual Congress, Rome, Italy, November 2012.
Chow E. Development and Validation of EORTC BM 22 Bone Metastases Module. Department of
Clinical Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong,
China, March 2012.
Chow E. Development and Validation of EORTC BM 22 Bone Metastases Module. Taipei-Veterans
General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan,
March 2012.
Chow E. ESTRO-CARO Joint Symposium on Bone Metastases Treatment in Elderly Patients: The
Added Challenges of Bone Metastases Treatment in Elderly Patients. European Society for
Therapeutic Radiotherapy and Oncology Annual Meeting, Barcelona, Spain, May 2012.
Chow E. Impact of Bone Metastases on Patients and Oncological Management. Cancer in the
Bones: Targeting the Pain, Liberating the Patient. International Association for the Study of
Pain/World Pain Congress ProStrakan Associated Symposium, Milan, Italy, August 2012.
Chow E. Implication of EORTC BM 22 Questionnaire in Breast Cancer Patients with Bone
Metastases. Pre-meeting of Annual Meeting of Taiwan Association of General Surgery, Taipei,
Taiwan, March 2012.
Cunha M, Al-Omair A, Atenafu E, Letourneau D, Korol R, Yu E, Masucci L, da Costa L, Fehling MG,
Sahgal A. The risk of vertebral compression fracture (VCF) post-spine stereotactic body
radiotherapy (SBRT) and evaluation of the spinal instability neoplastic score (SINS). Congress of
Neurologic Surgeons, Chicago, Illinois, USA. Neurosurgery 71(2): E571, 2012.
Cunha M, Al-Omair A, Atenafu E, Letourneau D, Korol R, Yu E, Masucci L, da Costa L, Fehling MG,
Sahgal A. The risk of vertebral compression fracture (VCF) post-spine stereotactic body
radiotherapy (SBRT) and evaluation of the spinal instability neoplastic score (SINS). Congress of
Neurologic Surgeons, Chicago, Illinois, USA, October 6-10, 2012.
Dennis K. Timing and duration of 5-HT3 receptor antagonist therapy for the prophylaxis of
radiotherapy-induced nausea and vomiting; a review of randomized and non-randomized trials.
UT DRO Research Day, May 5, 2012.
Emmenegger U. Denosumab Clinical Data Review. Canadian GU Medical Oncologist Advisory
Board (Amgen Inc.), Banff, Alberta, Canada, June 22, 2012.
32
Fawaz K, Smith A, Yee A. Anterior sacral resection and pelvic exenteration for recurrent rectal
carcinoma: patient selection, surgical technique, and outcomes. University of Toronto,
Department of Surgery, Annual SpineFEST Visiting Professorship. Toronto, Ontario, June 15,
2012.
Herblum R and Whyne CM. Structural Evaluation of Whole Vertebrae through Micro Finite
Element Modeling and Histological Damage Assessment. Canadian Orthopaedic Research Society,
46th Annual Meeting, Ottawa, Ontario, June 8–10, 2012.
Herblum R, Whyne CM. A Novel Method Demonstrating That μFEA Can Successfully Identify
Damage in Whole Vertebrae. Orthopaedic Research Society, 2012 Annual Meeting, San
Francisco, California, USA, February 4-7, 2012.
Hird A, Lemke M, Turovsky M, DeAngelis C, Chow E, Ko Y. Doctor, What are my Options? A
Prospective Cohort Study of an Individualized Care Plan for Gastrointestinal Cancer Patients.
ASCO‘s Quality Care Symposium, San Diego, California, USA, November 30-December 1, 2012.
Hojjat SP, Beek M, Wise-Milestone L, Akens M; Whyne CM. Quantifying the mechanical behavior
of mixed osteolytic/osteoblastic spinal metastases: A comparison of µCT based image
registration and multimodal finite element modeling. Orthopaedic Research Society, 2012 Annual
Meeting, San Francisco, California, USA, February 4-7, 2012.
Hojjat SP, Wise-Milestone L, Akens M; Whyne CM. Evaluation of the Ability of µCT-based
Structural Rigidity and Image-Based Strain Measurement in Predicting Yield Loads in Healthy and
Metastatically Involved Rat Vertebrae. Orthopaedic Research Society, 2012 Annual Meeting, San
Francisco, California, USA. February 4-7, 2012.
Hyde D, Sangha A, Korol R, Lochray F, Sahgal A. Treating multiple vertebrae using cone-beam
CT image-guidance and the hexapod robotic couch. American Association of Physics in Medicine,
Charlotte, North Carolina, USA. Medical Physics 39(7): 4642, 2012.
Lo V, Akens M, Moore S, Yee A, Wilson B, Whyne CM. Effects of photodynamic therapy in
combination with radiation therapy on healthy and metastatically-involved vertebrae. Canadian
Orthopaedic Research Society, 46th Annual Meeting. Ottawa, Ontario, June 8–10, 2012.
Lo V, Akens M, Wise-Milestone L, Yee A, Wilson B, Whyne CM. Long-term effects of
photodynamic therapy on healthy vertebrae alone and in combination with bisphosphonate or
radiation therapy. Orthopaedic Research Society, 2012 Annual Meeting, San Francisco, California,
USA, February 4-7, 2012.
Ma L, Sahgal A, Kirby N, Larson D.SU-E-T-253: Assessing small-volume cord biological effective
doses for repeat spinal stereotactic body radiotherapy treatments. American Association of
Physics in Medicine, Charlotte, North Carolina, USA. Medical Physics 39(6): 3761, 2012.
Nam D, Mau E, Wang Y, Silkstone D, Whyne CM, Alman B. T-Lymphocytes Enable Osteoblast
Maturation During Early Phases of Fracture Repair. Orthopaedic Research Society, 2012 Annual
Meeting, San Francisco, California, USA, February 4-7, 2012.
Pakdel A, Robert N, Fialkov J, Whyne CM. Localized Correction of Cortical Bone Geometry and X-
Ray Intensity Information in Clinical CT Images. 20th Annual symposium on Computational
Methods in Orthopaedic Biomechanics, University of California Berkeley, Berkeley, California,
USA, February 3, 2012.
Pakdel A, Robert N, Fialkov J, Whyne CM. Localized correction of thin-bone geometry and x-ray
intensity information in clinical CT imgaes. Canadian Orthopaedic Research Society, 46th Annual
Meeting, Ottawa, Ontario, June 8–10, 2012.
33
Pakdel A, Whyne CM, Fialkov J. Correction of Cortical Bone Geometry and Intensity information
CT images. 2012 Gallie Day, University of Toronto, May 4, 2012.
Pedeshki P. Preclinical ablation and MR imaging of bone metastases using a novel bipolar cooled
radiofrequency (BCRF) probe. University of Toronto, Department of Surgery, 38th Gallie Day.
Toronto, Ontario, May 4, 2012.
Pezeshki P, Akens MK, Woo J, Won E, Yee A, Whyne CM. Novel Bipolar Cooled Radiofrequency
(BCRF) Probe Application in a Preclinical Bone Metastatic Model; MR Imaging Implications.
Orthopaedic Research Society, 2012 Annual Meeting, San Francisco, California, USA, February 4-
7, 2012.
Pezeshki P, Whyne CM, Yee A. Preclinical Albation and MR Imaging of Bone Metastasis using a
Novel Biopolar Cooled Radiofrequency (BCRF) Probe. 2012 Gallie Day, University of Toronto, May
4, 2012.
Pezeshki P, Woo J, Akens M, Won E, Yee A, Whyne CM. MR Imaging can Quantify Large Areas of
Ablation Generated with a Novel Bipolar Cooled Radiofrequency (BCRF) Probe in a Preclinical
Bone Metastatic Model. Canadian Orthopaedic Research Society, 46th Annual Meeting, Ottawa,
Ontario, June 8–10, 2012.
Pezeshki P, Woo J, Won E, Akens MK, Whyne CM, Yee A. Cooled Bipolar Radiofrequency Yields
Large Contained Areas of Ablation in the Porcine Spine. Orthopaedic Research Society, 2012
Annual Meeting. San Francisco, California, USA, February 4-7, 2012.
Sahgal A. A revolution in radiation treatment-new techniques and radiosurgery. Hamilton health
care professional's workshop. Brain Tumour Foundation of Canada, Hamilton, Ontario, Canada,
2012.
Sahgal A. Advanced radiation technology in the roles of brain tumours and brain metastases.
Department of Surgery, Division of Neurosurger, Resident Academic Teaching Block on Tumours,
University of Toronto, Toronto, Ontario, Canada, 2012.
Sahgal A. Advanced technology in the management of brain metastases. Southlake Regional
Cancer Centre Oncology Rounds, Newmarket, Ontario, Canada, 2012.
Sahgal A. Basics of Radiation Oncology. Head and Neck Imaging – A Practical Approach. Toronto,
Ontario, Canada, 2012.
Sahgal A. Developing a paraspinal SBRT program: Prepare to launch. Princess Margaret Hospital
Paraspinal IGRT Education Course, University of Toronto, Toronto, Ontario, Canada, 2012.
Sahgal A. Introduction to CNS Tumours and Radiosurgery. Odette Cancer Centre, CNS Site
Group, Sunnybrook Health Sciences Centre, University of Toronto, Grand Rounds. University of
Toronto, Toronto, Ontario, Canada, 2012.
Sahgal A. Late effects of SBRT. Princess Margaret Hospital Paraspinal IGRT Education Course,
University of Toronto, Toronto, Ontario, Canada, 2012.
Sahgal A. Late effects to the spinal cord and bone: A new paradigm in the era of spine SBRT.
American Society of Therapeutic Radiation Oncology, Spine Innovative approaches to the
management of spinal metastases workshop, Boston, Massachusetts, USA, 2012.
Sahgal A. Lessons from Toronto's own Jackie Smith as she dies from cancer. Interview featured,
Toronto Star, April 22, 2012.
34
Sahgal A. Malignant epidural spinal cord compression (MESCC) and the future of radiation with
spine radiosurgery. Community Endocrinology Rounds, Toronto, Ontario, Canada, 2012.
Sahgal A. Multimodality registration for treatment planning exercise. Princess Margaret Hospital
Paraspinal IGRT Education Course, University of Toronto, Toronto, Ontario, Canada, 2012.
Sahgal A. New hope for patients with brain cancer, Globe and Mail article, April 9, 2012.
Sahgal A. Non-surgical treatment of spinal metastases- When to consider spine radiosurgery. 7th
Annual Canadian Contemporary Spinal Techniques Course. Toronto, Ontario, Canada, 2012.
Sahgal A. Paraspinal disease: Setting the stage, Princess Margaret Hospital Paraspinal IGRT
Education Course, University of Toronto, Toronto, Ontario, Canada, 2012.
Sahgal A. Paraspinal SBRT in action. Princess Margaret Hospital Paraspinal IGRT Education
Course, University of Toronto, Toronto, Ontario, Canada, 2012.
Sahgal A. Radiosurgery for multiple brain metastases: The future is now. Japanese Association of
Therapeutic Radiation Oncology, Tokyo, Japan, 2012.
Sahgal A. Spinal cord tolerance for Spine SBRT. 5th Annual International Symposium on
Stereotactic Body Radiation Therapy and Stereotactic Radiosurgery, Orlando, Florida, USA, 2012.
Sahgal A. Spinal tumors and outcome issues –RANO session. Society of Neuro-Oncology,
Washington, District of Columbia, USA, 2012.
Sahgal A. Spine stereotactic body radiotherapy: Current practice and future directions.
Department of Radiation Medicine Oncology Rounds, University of Toronto, Toronto, Ontario,
Canada, 2012.
Sahgal A. Stereotactic Body Radiotherapy for High Risk Spinal Metastases: SBRT vs. CRT for
complex spinal metastases –NCIC CTG SC.24. National Cancer Institute of Canada Clinical Trials
Group Symptom Control Committee. Toronto, Ontario, Canada, 2012.
Sahgal A. Stereotactic radiosurgery for spinal tumours. 37th Annual Willian S. Keith Professorship
in Neurosurgery, Division of Neurosurgery, Department of Surgery, University of Toronto,
Toronto, Ontario, Canada, 2012.
Sahgal A. Stereotactic radiosurgery for spine tumors. 12th Annual Anna Speranza-Miller MD
Symposium, Advocate General Lutheran Hospital, Chicago, Illinois, USA, 2012.
Sahgal A. Treatment planning in paraspinal SBRT-From targets to plan optimization. Princess
Margaret Hospital Paraspinal IGRT Education Course, University of Toronto, Toronto, Ontario,
Canada, 2012.
Sahgal A. Vertebral Compression Management – Treatment Options for Tumor and Oncology-
Related Verteberal Compression Fractures. AIM Health Group, Kitchener, Ontario, Canada, 2012.
Sahgal A. Why spine SBRT? Target Insight V1. Toronto, Ontario, Canada, 2012.
Sinclair E. Bone Pain Management, Case Studies from the RRRP and BMC. Pain Management
Event, Toronto, Ontario, Canada, February 22, 2012.
Sinclair E. Teaching on Palliative Care, Toronto, Ontario, Canada, May 31, 2012.
35
Sinclair E. Workshop on Pathways to Advanced Practice in Palliative Care. 17th International
Society of Radiographers and Radiological Technologists (ISRRT) World Congress and 70th
Canadian Association of Medical Radiation Technologists (CAMRT) Annual General Conference,
Toronto, Ontario, Canada, June 7-10, 2012.
Whyne CM. Canadian Operational Research Society, Spine Session, June 2012.
Whyne CM. CBC resident boot camp. Choosing a research project and hypotheses/specific aims,
October 15, 2012.
Whyne CM. Metastatic bone bioengineering and treatment, BONUS symposium, Ottawa, April
2012.
Whyne CM. Summer Student Seminar: Cancer in the spine: a bioengineering approach.
Sunnybrook Health Sciences Centre, Toronto, Ontario, June 13, 2012.
Whyne CM. Young Investigators Initiative Workshop. US/Canadian Bone and Joint Initiative, April
13, 2012.
Wright D, Nam D, Wang Y, Beek M and Whyne CM. A comparison of stereology, structural rigidity
and a novel measure of 3D bone connectivity in the assessment of torsional strength and
stiffness in a mouse tibia fracture model.Canadian Orthopaedic Research Society, 46th Annual
Meeting, Ottawa, Ontario, June 8-10, 2012.
Yee A. 3rd Annual Division of Orthopaedics Fellowship Day. Division of Orthopaedic Surgery,
Toronto, Ontario, June 21, 2012.
Yee A. Annual Research Update Meeting. UT Department of Surgery Spine Program, Toronto,
Ontario, August 7, 2012.
Yee A. Competency in Spinal Surgery in Canada - Perspective on cognitive and procedural
competencies by our fellows as well as supervisors alike. Canadian Spine Society - Fellowship
Symposium. Sun Peaks, British Columbia, March 2, 2012.
Yee A. Innovation & Evolution -- Implementation Updates from the Divisional Research
Translation Action Committee. Division of Orthopaedics. Toronto, Ontario, April 16, 2012.
Yee A. Innovation and Development in Divisional Fellowship Activities - an Update. Division of
Orthopaedics. Toronto, Ontario, April 16, 2012.
Yee A. Opportunities for Interprofessional Collaboration (IPC) Interventions in Acute Spinal Care.
Ontario Neurotrauma Foundation (Inaugural OSCIRN Meeting). Niagara Falls, Ontario, April 28,
2012.
Yee A. Overview - Department of Surgery Fellowship Education Program. Department of Surgery,
University of Toronto, Ontario, June 22, 2012.
Yee A. Perspectives on Bone and Joint Health in Canada. Young Investigator‘s Initiative
Workshop. Chicago, Illinois, USA, November 3, 2012.
Yee A. Presenter(s): Padina Pedeshki. Preclinical ablation and MR imaging of bone metastases
using a novel bipolar cooled radiofrequency (BCRF) probe. Canadian Orthopaedic Research
Society / Canadian Orthopaedic Association Annual Meeting. Ottawa, Ontario. June 8, 2012.
Yee A. Re-visiting UT SpineLINK. University of Toronto, Department of Surgery, Annual
SpineFEST Visiting Professorship. Toronto, Ontario, June 15, 2012.
36
Yee A. Symposia -- The Future of Spine Subspecialty Training and Accreditation. Canadian Spine
Society. Sun Peaks, British Columbia, March 2, 2012.
Yee A. Translational Research Opportunities for Vertebral Metastases: Phase I PDT trial. Odette
Cancer Centre, MCC Breast Tumor Board Rounds, Toronto, Ontario, November 22, 2012.
Yee A. Treating Cancer Spread to the Spine: Translating Research from the Clinic to the Bench
and Back. Canadian Orthopaedic Association (COA) Annual Meeting. Ottawa, Ontario, June 8,
2012.
Yee A. University of Toronto, Department of Surgery, Annual SpineFEST Visiting Professorship.
Toronto, Ontario, June 15, 2012.
Zeng L, Chow E, Bedard G, Zhang L, Fairchild A, Vassiliou V, Alm El-Din MA, Jesus-Garcia R,
Kumar A, Forges F, Tseng LM, Hou MF, Chie WC, Bottomley A. An International Prospective
Study Establishing Minimal Clinically Important Differences in the EORTC QLQ-BM22 and QLQ-
C30 in Cancer Patients with Bone Metastases. 19th Annual Conference of the International
Society for Quality of Life Research, Budapest, Hungary, Qual Life Res 21:69, 2012 (suppl; abstr 1099), October 2012.
37
APPENDIX A
Rapid Response Radiotherapy Palliative Clinics
http://www.sunnybrook.ca/content/?page=2341
Staff: Dr. E. Chow (Rad Onc), Dr. C. Danjoux (Rad Onc), Dr. M. Tsao (Rad Onc),
Dr. T. Barnes (Rad Onc), Dr. A. Sahgal (Rad Onc), L. Holden (RT), N. Lauzon (RT).
Objective:
Provide expedited access for symptom relief from incurable cancers in patients with limited life
expectancies.
Eligible Patients:
Symptomatic cancer (any disease site) where palliative radiotherapy may be indicated.
Patients with life expectancies of <6 months.
A ―most responsible physician‖ available to provide follow-up and ongoing oncological care
upon completion of the RRRP consultations.
Ineligible Patients:
1. Candidates for potentially curative treatments.
2. Patients requiring further investigations before radiotherapy opinion can be rendered.
3. Patients who are currently actively being followed by a radiation oncologist at
OCC (unless otherwise specifically arranged).
4. Patients whose disease status is better served by a radiation oncologist who could provide
longitudinal follow-up.
5. Off-service in-patients who require transfer of care to radiation oncology for ongoing oncological
care.
Monday Dr. T. Barnes Sim 4
Tuesday Dr. M. Tsao Sim 4
Wednesday Dr. C. Danjoux Sim 4
Thursday Dr. E. Chow Sim 4
Friday Dr. M. Tsao Sim 4
To make a referral:
1. Fill out an e sheet when requesting a referral to the RRRP clinic.
2. Contact the RRRP nurse.
3. Contact one of the RRRP physicians directly.
38
APPENDIX B
Decision Tree for Patients Referred to RRRP / BMC (January 2001)
Yes No
No
Yes No
Yes
Refer to his / her Rad Onc
To site group based on diagnosis
- lung
- breast - GU etc.
Emergency Urgent Elective < 24 h <1 week Book next available RRRP slot
(Cord Compression (Bleeding, Do not book beyond 2 weeks SVCO) SOB)
No Yes
YES YES
No
** RRRP Policy circulated as addendum to Minutes of Radiation Oncology staff meeting of March 2
nd 2000.
Is patient new to TSRCC?
Did patient see a TSRCC Rad Onc?
Is patient estimated
survival greater than 6 months?
What is the urgency of
appointment?
Is RRRP slot available?
Discuss with RRRP Rad Onc who has a clinic for that day or next few days. Is RRRP Rad Onc able to see patient?
overbook patient to Rad Onc in RRRP inform ref MD and patient
Refer to Rad Onc on call
39
APPENDIX C
Jan 1999: Initiated Bone Metastases Clinic (BMC)
A bi-weekly Bone Metastases Clinic (BMC) was initiated at the OCC on January 8, 1999. The clinic
is staffed by Orthopaedic Surgical Oncologists: Drs. J. Finkelstein, M. Ford and A. Yee; Radiation
Oncologists: Drs. E. Chow, C. Danjoux, M. Tsao, T. Barnes; Advanced Practice Radiation Therapist
and the Pain Nurse.
The BMC is held on the 2nd and 4th Friday morning of each month in clinic B at the OCC.
The goals of the BMC are to:
Provide an elective orthopaedic consultation service for patients with bone metastases
referred by OCC oncologists; provide elective radiation oncology consultations to patients
with bone metastases referred by SWHSC physicians.
Provide elective orthopaedic and radiation oncology consultations to patients with bone
metastases referred by community physicians.
Provide follow-up to oncology patients after orthopaedic interventions.
Bone Metastases Clinic – 2nd and 4th Friday (Clinic B)
To make a referral:
1. Fill out an e sheet when requesting a referral to the Bone Metastases Clinic.
2. Contact the RRRP nurse or Radiation Therapist.
3. Contact one of the RRRP physicians directly.
40
APPENDIX D
41
42
43
44
45
46
47
48
49
50
51
52
53
54
APPENDIX E [Back]
Content of HOT SPOT Newsletter
1999-2012
55
CONTENT AND INSERTS OF HOT SPOT 1999-2012
Vol 1, Issue 1 February 1999
Editor‘s Corner Dr. Gillian Thomas
From the Chief Executive Officer Dr. Ken Shumak
The first RRRP newsletter Dr. Gillian Thomas
Palliative radiotherapy rounds Dr. Ewa Szumacher
New combined bone metastases clinic Drs. Joel Finkelstein, Edward Chow
A phase II trial of palliative radiotherapy for metastatic renal cell carcinoma
Drs. Edward Chow, Padraig Warde
Prospective assessment of symptom palliation for patients attending a rapid response radiotherapy program
Drs. Edward Chow, Cyril Danjoux, Rebecca Wong
The challenge of speedy delivery of pain relief met by the rapid response clinic at T-SRCC
Dr. Ewa Szumacher, Ms. Lou Andersson
The cancer pain and palliative care clinic at T-SRCC Dr. Larry Librach
Research Corner Dr. Rebecca Wong
Vol 1, Issue 2 May 1999
Message from the Chief Executive Officer Dr. Carol Sawka
A note of thanks
Ms. Ruth Connolly,
Dr. Edward Chow
Editor‘s Corner
Differentiating normal grief from clinical depression Dr. Mary Vachon
Ontario Drug Benefit (ODB) Formulary Changes Ms. Trudi Schueller
Surgical management of metastatic spine disease Dr. Joel Finkelstein
Radiosurgery for brain metastases Dr. Phillip Davey
Surgical management of metastatic extremity lesions Dr. David Stephen
Highlights in the Multinational Association of Supportive Care Cancer Dr. Rebecca Wong
Insert May 1999
Cancer Related Pain Management (Sponsored by Janssen-Ortho Inc.) Dr. David Warr
Vol 1, Issue 3 August 1999 Referring physicians‘ satisfaction with the RRRP
Ms. Ruth Connolly, Dr. Edward Chow
Preparing the community and health care professionals for new challenges
in palliative care – a new endeavour of the rapid response radiotherapy program
Ms. Lou Andersson, Dr. Ewa Szumacher
Editor‘s Corner
Management of bone metastases with external beam radiotherapy Drs. Ewa Szumacher and Rebecca Wong
Single dose wide field radiotherapy Dr. Cyril Danjoux
Bisphosphonates in palliative care Dr. Sandeep Sehdev
Mitoxantrone and prednisone for hormone refractory prostate cancer Dr. Scott Berry
Research Corner Dr. Rebecca Wong
Insert August 1999
Malignant wound management (Sponsored by Convatec) Dr. Valerie Schultz
Vol 1, Issue 4 November 1999
Bayview Support Network: Ontario‘s first on-site cancer support network Ms. Mridula Sood
Dope and cope: it is no longer enough Dr. Michele Chaban
Editor‘s comment
Psychosocial issues with a cancer diagnosis Dr. Margaret Fitch
Cancer care at York Central Hospital Ms. Jane Anderson
Yee Hong palliative care services: A culturally sensitive approach Dr. Stanley Zheng
Hill House – A Richmond Hill hospice Ms. Ann Gold
56
Charles R.R. Hayter, MD, BA, MA, FRCPC joins T-SRCC
Interview with Russell Goldman, MD, CCFP, palliative care physician with
the Temmy Latner Centre for Palliative Care, Mount Sinai Hospital
Research Corner Dr. Rebecca Wong
Insert November 1999
Bowel Obstruction Dr. Larry Librach
Management of Radiotherapy-Induced Acute Gastrointestinal Toxicities Dr. Rebecca Wong
(Sponsored by Novartis Pharmaceuticals Canada, Inc.)
Vol 2, Issue 1 February 2000
Editor‘s comments Dr. Cyril Danjoux
Advance care planning for people with cancer Dr. Scott Berry
The emotional needs of the person with advanced cancer Dr. Mary Vachon
Historical Vignette: The beginnings of palliative radiotherapy in Canada Dr. Charles Hayter
When does palliative care begin? Dr. Larry Librach
Palliative radiation oncology program at the Princess Margaret Hospital Dr. Andrea Bezjak
Ask the Experts Dr. Rebecca Wong
Research Corner Dr. Rebecca Wong
Insert February 2000
Prevention and treatment of radiation-induced emesis Dr. Rebecca Wong
Prevention and treatment of chemotherapy-induced nausea and vomiting (N&V) - (Sponsored by Glaxo-Wellcome) Mr. Carlo De Angelis
Vol 2, Issue 2 May 2000
From the associate editor‘s desk Dr. Edward Chow
Enhancing culturally sensitive practice when caring for seriously ill patients and their families Dr. Elizabeth Latimer
Quality end-of-life care: What do patients think? Dr. Scott Berry
Family dealing with advanced cancer Dr. Mary Vachon
Percutaneous vertebroplasty / cementoplasty at bone metastases clinic, TSRCC Dr. Edward Chow
Historical Vignette: Dr. Joseph-Ernest Gendreau and the early use of radium Dr. Charles Hayter
Research Corner Dr. Rebecca Wong
Insert May 2000 Accessing palliative care in your community
Ms. Joan Pope,
Ms. Lou Andersson
Vol 2, Issue 3 August 2000 From the editorial board
Dr. Ewa Szumacher, Ms. Ruth Connolly
When the patient of a young child is seriously ill Dr. Mary Vachon
Disclosure Dr. Philip Hebert
Utilization of complementary therapies in palliative care Ms. Ruth Connolly
Historical Vignette: Private radiotherapy in Canada Dr. Charles Hayter
Research Corner - Summer research for the Rapid Response Radiotherapy Program Dr. Rebecca Wong
Andrew Loblaw, MD, FRCPC, joins T-SRCC
Insert August 2000
-Nutrition and cancer
-The ABCs of vitamins and minerals (Supported by Novartis Pharmaceuticals Canada, Inc.) Ms. Elaine Posluns
Vol 2, Issue 4 November 2000
Editor‘s Corner Dr. Rebecca Wong
Report from the ―tri-centre‖ meeting with Dr. William E. Powers Dr. Jackson Wu
Adolescents living with a parent with advanced illness Dr. Mary Vachon
Resources on the Internet for improving end-of-life care – How to get started Dr. Scott Berry
Historical Vignette: Vera Peters: Canadian pioneer in psychosocial oncology Dr. Charles Hayter
Research Corner – Informational needs assessment on patients receiving palliative radiotherapy Dr. Rebecca Wong
57
Seventh Annual Conference – The Science and Art of Pain and Symptom Management
Insert November 2000
Cancer-related fatigue -Supported by an educational grant from Janssen-Ortho Inc. Dr. Rebecca Wong
Vol 3, Issue 1
February 2001 From the associate editor‘s desk Dr. Edward Chow
Dr. Maureen Trudeau Dr. Kathleen Pritchard
Staff stress and suffering Dr. Mary Vachon
Historical Vignette: Cancer care before medicare Dr. Charles Hayter
Pain and symptom management conference
Follow-up for breast cancer Dr. Eva Grunfeld
Research Corner – Shared treatment decision-making Dr. Rebecca Wong
Thank you…
Insert February 2001
-Hormones in Breast Cancer, Metastatic Breast Cancer (Supported by Astra-Zeneca Canada Inc.)
Dr. Maureen Trudeau
-Chemotherapy in Metastatic Breast Cancer Treatment, Treatment of
Systemic Recurrence with Chemotherapy (Supported by Aventis)
Dr. Maureen Trudeau
-Herceptin (Supported by Hoffman LaRoche) Dr. Maureen Trudeau
Vol 3, Issue 2 May 2001
From the guest editor's desk Dr. Charles Hayter
Addressing spiritual needs Dr. Sharon Grant
When the shrink gets cancer and gets spiritually transformed Dr. Mary Vachon
Historical Vignette: The history of hospices Dr. Charles Hayter
Ethics: Caring for patients with different faiths Dr. Scott Berry
Research Corner - Patient expectations Dr. Rebecca Wong
Notice regarding treatment delays...
Insert May 2001
A guide to spiritual care of the caregiver, A guide to spiritual assessment of cancer patients. (Supported by AstraZeneca Canada Inc. and Purdue Pharma)
Dr. Michele Chaban
Vol 3, Issue 3 August 2001
From the editor's desk Dr. Cyril Danjoux
Comfort and stress among cancer caregivers Dr. Eva Grunfeld
On suffering in terminal illness Dr. Mary Vachon
Historical Vignette: The history of morphine Dr. Charles Hayter
Research Corner Dr. Rebecca Wong
Insert August 2001 Palliation in lung cancer
(Supported by AstraZeneca Inc. and Purdue Pharma)
Drs. Andrea Bezjak, Dr. Catherine Heath, Ms. Jane Lea
Vol 3, Issue 4 November 2001
From the guest editor's desk Dr. Andrew Loblaw, Ms. Lori Holden
Survey shows 40% of RRRP patients arrive with missing info: A plea for help
Dr. Charles Hayter, Ms. Ruth Connolly
Finding meaning in life in the face of advancing cancer Dr. Mary Vachon
Historical Vignette: The 50th anniversary of cobalt treatment Dr. Charles Hayter
Tough decisions about funding for new palliative therapies: How do we decide? Dr. Scott Berry
Research Corner Dr. Rebecca Wong
Insert November 2001
Malignant Spinal Cord Compression (Partially supported by Purdue Pharma)
Dr. Andrew Loblaw, Ms. Lori Holden
Vol 4, Issue 1 February 2002 From the editor's desk
Dr. Ewa Szumacher, Ms. Joan Pope
58
Advance notice of the ninth annual conference on the science and art of pain and symptom management
Denial and minimization in advanced cancer Dr. Mary Vachon
Global health ethics and palliative care Dr. Scott Berry
Historical Vignette: The story of Essiac Dr. Charles Hayter
Research Corner Dr. Rebecca Wong
Insert February 2002
Oral health care in the patient with cancer Dr. Trey Petty
Mouth care for radiation patients Dr. Alex Hammond
(Supported by Biotene Canada, Division of Bolton Dental Mfg. Inc.)
Vol 4, Issue 2
May 2002 From the associate editor‘s desk Dr. Edward Chow
New chiefs at TSRCC and University of Toronto Dr. Edward Chow, Dr. Cyril Danjoux
Depression in advanced cancer Dr. Mary Vachon
Historical Vignette: Blood and medicine Dr. Charles Hayter
Hope for a good death Dr. Monica Branigan
Research Corner Dr. Rebecca Wong
Insert May 2002
Anemia in hematology and medical/radiation oncology (Supported by Ortho Biotech)
Dr. Gerard Morton, Dr. Rena Buckstein
Vol 4, Issue 3 August 2002 From the associate editor‘s desk
Ms. Lou Andersson, Dr. Cyril Danjoux
TSRCC pharmacy services Ms. Kim Stefaniuk
The transformation from tragedy into grace in terminal illness – part one Dr. Mary Vachon
Historical Vignette: Plants, poisons and potions: Drug treatments for cancer Dr. Charles Hayter
TSRCC pharmacy assists Third World countries Ms. Kim Stefaniuk
Informed decision-making in palliative care Dr. Scott Berry
Research Corner Dr. May Tsao, Dr. Rebecca Wong
Insert August 2002
Accessing medication
(Supported by Amgen Canada and Abbott Laboratories) Ms. Kim Stefaniuk
Vol 4, Issue 4 November 2002
From the associate editor‘s desk Dr. Edward Chow
Palliative care is not euthanasia Dr. Monica Branigan
The transformation from tragedy into grace in terminal illness – part two Dr. Mary Vachon
Palliative care at the University of Texas M.D. Anderson Cancer Center Dr. Toni Barnes
Historical Vignette: Charles Huggins: The Canadian who discovered hormone therapy for prostate cancer Dr. Charles Hayter
Research Corner Dr. Rebecca Wong
Award of Excellence Dr. Cyril Danjoux
Insert November 2002
Expanded role of hormone therapy as neoadjuvant or adjuvant therapy in
prostate cancer patients undergoing definitive treatment. (Supported by Aventis)
Dr. Richard Choo
Vol 5, Issue 1 February 2003 From the editor‘s desk
Drs. Cyril Danjoux,
Edward Chow
Congratulations on fifth year Dr. Carol Sawka
Congratulations on fifth year Dr. Peeter Poldre
Suffering, healing and the wounded healer Dr. Mary Vachon
More fifth year congratulations Dr. Shun Wong
Advance care planning – update and practical tips Dr. Scott Berry
Historical Vignette – A century of radiation therapy in Canada Dr. Charles Hayter
Research Corner Dr. Rebecca Wong
59
Insert February 2003
Pain in cancer: The CARE approach Dr. Larry Librach
Vol 5, Issue 2 May 2003 From the guest editor‘s desk
Dr. Charles Hayter,
Ms. Lou Andersson
The role of the social worker in palliative oncology Ms. Magdalene Winterhoff
Reflections on anxiety in confronting advanced cancer Dr. Mary Vachon
Historical Vignette – Spring fever Dr. Charles Hayter
Research Corner Dr. Rebecca Wong
Insert May 2003
Advances and challenges in the management of febrile neutropenia. (Supported by Amgen Canada Inc.)
Dr. Elizabeth J. Phillips
Vol 5, Issue 3 August 2003
From the guest editor‘s desk Dr. Toni Barnes
Lymphoma in the elderly Dr. Tom Kouroukis
Demorarlization in persons with advanced cancer Dr. Mary Vachon
Ethical issues in dealing with demands for ―futile‖ treatment Dr. Scott Berry
Historical Vignette – The history of oxygen therapy Dr. Charles Hayter
Research Corner Dr. Rebecca Wong
Insert August 2003 Advances for end-of-life respiratory care (Supported by Vital Aire) Dr. Chin K. Chung
Vol 5, Issue 4 November 2003
From the guest editor‘s desk Dr. Cyril Danjoux
Referral of patients to the rapid response radiotherapy clinic
Boredom in terminal illness Dr. Mary Vachon
Hot Spot Survey 2003
―No CPR‖ – Talking it over Dr. Scott Berry
Historical Vignette – The Radium Institute of Toronto Dr. Charles Hayter
Research Corner Dr. Andrea Bezjak
Insert November 2003 Androgen ablation for metastatic prostate cancer (Supported by Aventis)
Dr. Richard Choo
Vol 6, Issue 1 February 2004
From the guest editor‘s desk Dr. May Tsao
Brain metastases: The magnitude of the problem and the struggle to improve outcomes Dr. May Tsao
Dignity-conserving care in palliative care Dr. Mary Vachon
When capacity fluctuates, what happens to consent? Ms. Karen Faith
Historical Vignette: The Montreal Neurological Institute Dr. Charles Hayter
Research Corner Dr. Alina Sturdza, Dr. Andrea Bezjak
Insert February 2004
Palliation in patients with metastatic cancer to the brain
Management of brain metastases (Supported by Aventis)
Dr. May Tsao
Vol 6, Issue 2 May 2004
From the guest editor‘s desk Dr. Charles Hayter
Bisphosphonates in cancer Dr. Rebecca Wong
Anger in the person with advanced disease Dr. Mary Vachon
Ethics and SARS: Collateral damage and relationships in health care Ms. Karen Faith
Historical Vignette: Dr. Herbert Bruce: Ontario cancer visionary Dr. Charles Hayter
Research Corner Dr. Jackson Wu, Dr. Edward Chow
Insert May 2004
Use of bisphosphonates in men with hormone refractory prostate cancer Use of bisphosphonates in women with breast cancer
Dr. Scott Berry Dr. Mark Clemons
Vol 6, Issue 3 From the guest editor‘s desk Dr. Cyril Danjoux
60
August 2004 Supportive Care in Cancer Symposium Dr. Cyril Danjoux
Forgiveness in palliative care Dr. Mary Vachon
Making decisions for others Ms. Karen Faith
Survey shows 40% of RRRP patients arrive with missing info: A plea for help
Dr. Charles Hayter, Ruth Connolly
Research Corner Dr. Laura Dawson
Insert August 2004
Rapid Response Radiotherapy Program (RRRP) Review 1996-2003 RRRP Referral Form
Dr. C. Danjoux
Vol 6, Issue 4 November 2004
From the guest editor‘s desk Dr. Edward Chow
The effect of SARS on access to palliative radiotherapy in the RRRP
Dr. Justin Lee, L. Holden, K. Fung,
C. Danjoux, E. Chow, C. Gillies
Reflections on the life and death of Mary Peacock Dr. Mary Vachon
Quality end-of-life care: Role of economics and the moral climate Ms. Karen Faith
Historical Vignette: The Canadian Society for the History of Medicine Dr. Charles Hayter
Research Corner
Dr. Jackson Wu,
Dr. Edward Chow
Insert November 2004
Cannabinoids in medical practice Dr. Vincent Maida
Vol 7, Issue 1 February 2005
From the guest editor‘s desk Dr. Toni Barnes
Treatment of bone metastases with palliative radiotherapy: Patients‘ treatment preferences
Dr. Ewa Szumacher
Parenting teens during a cancer experience Dr. Mary Vachon
Hospital CPR policy: Solution, prevention or band-aid? Ms. Karen Faith
Historical Vignette: Alfred Hardisty: Ontario‘s pioneer in cancer statistics Dr. Charles Hayter
Research Corner Dr. Rebecca Wong
Insert February 2005
Methadone for cancer pain: An analgesic with a difference Dr. Larry Librach
Vol 7, Issue2 May 2005
From the guest editor‘s desk Dr. Edward Chow
The do-not-resuscitate (DNR) order – incidence of documentation in patient charts of patients referred for palliative radiotherapy
Ms. Lou Andersson, Ms. Nicole Bradley
Caught in the middle – mid-life adults with cancer Dr. Mary Vachon
Does culture influence patients‘ and families‘ DNR decision-making?
Ms. L. Andersson,
S. Mary Williams, N. Bradley
Lessons from my dad Ms. Karen Faith
Temmy Latner Centre Update on Palliative Care – Palliative care and children
Mr. Stephen Jenkinson
PROG Rounds Dr. Tanya Berrang
Farewell to Dr. Charles Hayter Dr. Cyril Danjoux
Insert #1 May 2005
Latest advances in antiemetics for radiation therapy and chemotherapy
(Supported by an educational grant from Solvay) Dr. David Warr
Insert #2 May 2005
Novel therapeutics for management for multiple myeloma (Supported by an educational grant from Ortho Biotech)
Dr. Keith Stewart
Vol 7, Issue 3 August 2005
From the guest editor‘s desk Dr. Cyril Danjoux
A survey to asses cancer patients‘ awareness and interest in hypnosis for pain and distressing procedures – A synopsis
Mrs. Lori Holden, Dr. Charles Hayter
Are we making any progress? Reflections on stressors in the Ontario oncology system over the past 30 years Dr. Mary Vachon
Organizational ethics in the eye of the storm: Woodside Hospice and Terri Ms. Karen Faith
61
Schiavo
Temmy Latner Centre Update on Palliative Care – End-of-life care distance
education: An innovative approach to helping physicians to care for palliative patients
Dr. Anita Singh, Ms. Deborah Adams
TSRCC investigates advanced practice radiation therapy roles! Ms. S. Robson, R. Barker, L. Holden
Insert August 2005
A more minimally invasive approach to the treatment of metastatic spine lesions. (Supported by an educational grant from Kyphon)
Dr. Michael Ford
Vol 7, Issue 4 November 2005
From the guest editor‘s desk Dr. May Tsao
What keeps us going in our work? Dr. Mary Vachon
Research ethics and the importance of determining risk Ms. Karen Faith
Temmy Latner Centre Update on Palliative Care – Is terminal sedation ethical?
Dr. Victor Cellarius
Research Corner – Results of three important randomized studies and their clinical implications. Dr. Jackson Wu
Insert November 2005
Management of hormone refractory prostate cancer / Prostate bone
metastases multidisciplinary clinic. (Supported by an educational grant from Novartis)
Dr. Yoo-Joung Ko
Vol 8, Issue 1 February 2006
From the guest editor‘s desk Dr. Edward Chow
Greetings from Cancer Care Ontario Dr. Linda Rabeneck, Dr. Deb Dudgeon
Hope in advanced disease Dr. Mary Vachon
Temmy Latner Centre Update on Palliative Care – Palliative care grand rounds Ms. Deborah Adams
Private clinics providing palliative IV therapies – What are the ethical
issues? Dr. Scott Berry
Helping children and caregivers in fighting cancer – Truth telling in paediatric palliative care. Dr. Christine Newman
Research Corner Dr. Toni Barnes
Insert February 2006
Venous thromboembolism in cancer patients (Supported by an educational grant from Pfizer Canada) Dr. Agnes Y.Y. Lee
Vol 8, Issue 2 May 2006
From the guest editor‘s desk Dr. Cyril Danjoux
Truth-telling at the end of life Dr. Monica Branigan
What students think: Undergraduate students in palliative health care setting Ms. Hannah H. Chiu
Temmy Latner Centre Update on Palliative Care – The educating future physicians for palliative and end-of-life care project (EFPPEC): Developing competencies in medical undergraduates and postgraduates Dr. Larry Librach
Help no wanted? Dr. Margaret Fitch
If symptom clusters exist, how are they relevant to patient care? Dr. Amna Husain
Forgoing nutrition and hydration in children at the end of life: Is it ever justified? Dr. Adam Rapoport
Insert May 2006
Radioimmunotherapies
(Supported by an educational grant from GlaxoSmithKline) Dr. Rena Buckstein
Vol 8, Issue 3 August 2006
From the guest editor‘s desk Ms. Emily Sinclair
Hope, denial and ethics of care Ms. Karen Faith
The role of a child life specialist at the MBWC-CGPC Ms. Ceilidh Eaton Russell
Quality indicators of end-of-life care in Ontario cancer patients Dr. Lisa Barbera
Palliative care consult team: Moving forward Dr. Jeff Myers
16th Annual provincial conference on palliative and end-of-life care Ms. Emily Sinclair
62
Patients‘ and health care professionals‘ perspectives on the most important quality of life issues in bone metastases
Ms. S.Tharmalingam and Ms. Kristin Harris
Interprofessionalism: A culture of caring Dr. Michele Chaban
Insert August 2006
Video/teleconference as a tool to facilitate research and development in palliative radiotherapy – the Canadian model
Kathryn Burrows, Rebecca Wong,
Andrea Bezjak, Jackson Wu, Graeme Duncan, Rajiv Samant, Jim Wright, Frances Wong, and Cyril Danjoux
Vol 8, Issue 4 November 2006
From the guest editor‘s desk Dr. Toni Barnes
Ethics and preparing for pandemic influenza Ms. Karen Faith
Research Column – Symptom control abstracts presented at the annual Canadian Association of Radiation Oncologist (CARO) meeting
Dr. Toni Barnes
Demanding to live Mr. Stephen Jenkinson
Temmy Latner Centre Update on Palliative Care –Tariro (hope) Dr. Sandy Buchman
Communicating with children about dying Ms. Jennifer B. Pond, Ms. Ceilidh E. Russell
Exploring occupational therapy‘s role – Working with palliative clients and their families
Ms. Amy Tymchuk
Insert November 2006
New developments in the treatment of advanced renal cell carcinoma (RCC) (Supported by an educational grant from Pfizer) Dr. Yoo-Joung Ko
Vol 9, Issue 1 February 2007
From the guest editor‘s desk Dr. Lisa Barbera
The alchemy of healing: Are we wired for compassion? Dr. Mary Vachon
Provincial Palliative Care Integration Project (PPCIP): Enhancing the quality of palliative care services
Dr. Deborah Dudgeon and Raquel Shaw
Moxam
Issues in the measurement and management of dyspnea in home
palliative care patients: Who might benefit from oxygen therapy and how should they qualify?
Ms. Erica Moran and
Dr. Amna Husain
Redirecting hope Dr. Christopher
Church
Capacity and consent: Separating fact from fiction Mr. Blair Henry
Temmy Latner Centre Update on Palliative Care – Computerization in palliative care
Dr. Albert Kirshen
Insert Nov 2006
Advances in iron chelation for myelodysplastic syndromes (Supported by an educational grant from Novartis)
Dr. Rena Buckstein
Vol 9, Issue 2 May 2007
From the associate editor‘s desk Dr. Cyril Danjoux
…on the truth of the matter!?! Mr. Blair Henry
Living after cancer: Challenges in being a survivor Dr. Margaret Fitch
Improving communication during the palliative care of children with brain
tumours – learning from experience
Ms. Ceilidh Eaton
Russell
Symptom clusters in cancer patients with bone metastases Ms. Stephanie Hadi, Grace Fan, Linda
Filipczak
New imaging studies in locally advance breast cancer Drs. Gregory Czarnota, Rebecca Dent, Jacqueline Spayne, Maureen Trudeau, Kathleen
Pitchard, Martin Yaffe,
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Don Plewes, and Peter Burns
The Rapid Access Palliative Radiotherapy Program: New kid in town Dr. Alysa Fairchild
Insert May 2007
Emerging role of chemotherapy in early prostate cancer (Supported by an educational grant from Sanofi-Aventis)
Dr. Rena Buckstein
Vol 9, Issue 3 August 2007
From the editor‘s desk Dr. Edward Chow
Error in health care Dr. Philip Hebert
Edmond and Gloria Odette make landmark investment at Sunnybrook to help fight cancer
Ms. Natalie Chung-Sayers
Suffering, taboos and interventions Dr. Michele Chaban
New initiatives in advance care planning in Canada Dr. Larry Librach
Review of the Rapid Response Radiotherapy Program (RRRP) at the Odette Cancer Centre (OCC)
Dr. Toni Barnes
Insert August 2007
New options for the treatment of moderate pain (Supported by an educational grant from Purdue Pharma)
Dr. Sol Stern
Vol 9, Issue 4 November 2007
From the guest editor‘s desk Dr. May Tsao
What hope can mask: Talking to children about life-threatening illness and death
Ms. Lysa Toye
The role of experience and meaning in clinical ethics Ms. Karen Faith
The role of the therapeutic clown in the care of children with progressive
life-limiting conditions
Ms. Camilla Gryski
Provincial integration project moving forward at Odette Cancer Centre Ms. Martha Wyatt
Update: New options for the treatment of moderate pain Dr. Sol Stern
New research in palliative care Ms. Shannon Ellis, Ms. Linda Wood, Dr. Lorraine Wood
Health care professionals‘ perception of what defines ―meaningful palliative care‖ in a palliative care unit
Ms. Julie Napolskikh, Drs. Jeff Myers, Debbie Selby
Insert #1 November 2007
Update in the management of colorectal cancer (Supported by an educational grant from Sanofi-Aventis)
Dr. Yoo-Joung Ko
Insert #2 November 2007
The evolving role of cannabinoids in supportive oncology (Supported by and educational grant from Bayer Inc.
Dr. Vincent Maida
Vol 10, Issue 1 February 2008
From the guest editor‘s desk Dr. Toni Barnes
Talking to dying patients Dr. Scott Berry
Being ready for pediatric palliative care – a person reflection Dr. Christine Newman
Involvement of family physicians in the care of patients seen in the Rapid Response Radiotherapy Program
Dr. Toni Barnes
Resilience in palliative care Dr. Mary Vachon
The WHO analgesic ladder and new concepts in our understanding of cancer pain – building on the legacy
Dr. Carlo DeAngelis
Development of the Bone Metastases Module to accompany the EORTC
core questionnaire to assess quality of life in patients with bone metastases in future clinical trials
Ms. Amanda Hird
Insert February 2008
Management of invasive fungal infections (IFIs) in immunocompromised patients (Supported by an educational grant from Astellas Pharma Canada, Inc.)
Dr. Jeffrey H. Lipton
Vol 10, Issue 2 May 2008
From the associate editor‘s desk Dr. Cyril Danjoux
Resilience in professional caregivers Dr. Mary Vachon
Are some GIM patients missing a palliative medicine consult when they Drs. Leah Steinberg,
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might benefit from it? Anita Chakraborty, Niren Shetty
Advanced directives or advanced troubles? Mr. Blair Henry
Advance care planning in pediatric palliative care: Dr we really know what they are asking?
Ms. Maria Rugg
Improving cancer pain control: Helping patients to gain the most benefit
from their medication
Dr. Carlo DeAngelis
Insert May 2008
Sorafenib in the treatment of advanced heptocellular cancer (Supported by an educational grant from Bayer)
Ms. Anne Horgan, Dr. Jennifer Knox
Vol 10, Issue 3 August 2008
From the editor‘s desk Dr. Edward Chow
Only talk about positive things! Dr. Monica Branigan
Decision-making in a family dyad in the context of advanced cancer Ms. Susanna Edwards
Screening for emotional distress: The sixth vital sign Dr. Margaret Fitch
Opioid Dose Equivalency: Part 1 – General Overview Dr. Carlo DeAngelis
Insert #1 August 2008
Secondary prophylaxis of venous thromboembolism (VTE) in cancer patients (Supported by an educational grant from Pfizer)
Dr. Richard Jay
Insert #2 August 2008
Prostate bone metastases clinic (PBMC): A multidisciplinary approach (Supported by an educational grant from Novartis)
Dr. Urban Emmenegger
Vol 10, Issue 4 November 2008
From the guest editor‘s desk Dr. May Tsao
Spine stereotactic body radiotherapy Dr. Arjun Sahgal
Stereotactic body radiation therapy for lung tumours Dr. Patrick Cheung
Disclosure and palliative chemotherapy Dr. Philip Hebert
Determining outcomes for patients with metastatic epidural spinal cord
compression (MESCC): A quality of life and cost-effectiveness study
Dr. Arjun Sahgal, Ms.
Aimee Gallant, Drs. Michael Fehlings, Edward Chow, Joel Finkelstein
Bringing about change Dr. Michele Chaban
Insert November 2008
Smoking cessation and reduction in patients with cancers (Supported by
an educational grant from Pfizer)
Dr. Peter Selby
Vol 11, Issue 1
February 2009 From the guest editor‘s desk Dr. Toni Barnes
Maintaining Ontario‘s blood supply: A fine balancing act Ms. Debbie Lauzon
De Moto Sanquinas (on the movement of blood) Ethics across the spectrum of transfusion
Mr. Blair Henry
Psychosocial aspects of the use of blood products Dr. Mary Vachon Insert February 2009
Myelodysplastic syndromes (Supported by an education grant from Celgene)
Dr. Rena Buckstein
Vol 11, Issue 2 May 2009
From the editor‘s desk Dr. Edward Chow
―Be patient‖: Ethical considerations regarding wait times Ms. Karen Faith
Dying-centred care for the dying Mr. Stephen Jenkinson
Opioid dose equivalency: Part 2 – Changes in opioid route or mode of administration
Dr. Carlo DeAngelis
Integrating continuous quality improvement in a home palliative care program
Ms. Ceilidh Eaton Russell, Mr. Christopher Obwanga, Ms. Natalie Parry, Dr. Amna Husain
Nursing escort for patients attending Rapid Response Radiotherapy
Program (RRRP)
Ms. Lynn Faltl and
Pager Office Nursing Staff
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Insert
May 2009 Individualizing a cancer pain management strategy: Beyond the basics
(Supported by an education grant from Sanofi-Aventis)
Drs. Carlo DeAngelis,
Jeff Myers Vol 11, Issue 3 August 2009
From the associate editor‘s desk Dr. Cyril Danjoux
Limits of the duty of care: Lessons from the Golubchuk case Dr. Monica Branigan
A multicentre assessment of the adequacy of cancer pain treatment using the Pain Management Index
Ms. Gunita Mitera, Drs. Alysa Fairchild, Rebecca Wong
Opioid dose equivalency: Part 3 – Opioid switching with morphine-like opioids
Dr. Carlo DeAngelis
2009 Annual Hospice Palliative Care Conference Ms. Gunita Mitera Insert #1 August 2009
Chronic lymphocytic leukemia (CLL) (Supported by an education grant from Roche)
Dr. Rena Buckstein
Insert #2 August 2009
Treatment of chemotherapy- and radiotherapy-induced nausea and vomiting (CINV/RINV) (Supported by an education grant from Merck Frosst Canada Ltd.)
Drs. Mark Pasetka, Carlo DeAngelis
Vol 11, Issue 4 November 2009
From the guest editor‘s desk Dr. Arjun Sahgal
A brief primer on scarcity and fairness Dr. Philip Hébert
Are family caregivers an essential component of our health care system? Dr. Michele Chaban
Ethics Centre launches new on-line consult request on Sunnynet! Dr. Sally Bean
Improving data capture and standardization in a home palliative care program
Mr. Christopher Obwanga
Opioid dose equivalency: Part 4 – Dose conversion for transdermal fentanyl and methadone
Dr. Carlo DeAngelis
Insert #1 November 2009
Anti-epidermal growth factors in colorectal cancer (Supported by an education grant from Amgen)
Dr. Yoo-Joung Ko
Insert #2 November 2009
Management of symptomatic side effects of anti-hormonal therapy in breast cancer survivors (Supported by an education grant from Pfizer)
Dr. Christine Simmons
Vol 12, Issue 1 February 2010
From the guest editor‘s desk Dr. May Tsao
Projected referral for health care services in an outpatient palliative radiotherapy clinic
Ms. Roseanna Presutti, Dr. Elizabeth Barnes
Caring and moral distress: Why do I feel so bad? Ms. Karen Faith
An N of one at a time: A little national survey on good death Mr. Stephen Jenkinson
Breakthrough pain – A thorn by any other name would be as sharp Dr. Carlo DeAngelis
Patient and Family Support Program: The first year Drs. Jeff Myers, Margaret Fitch, Ms.
Pat Brown Insert #1 February 2010
Exercise and breast cancer (Supported by an education grant from Pfizer) Dr. Teresa Petrella
Insert #2
February 2010 Targeting RANK-ligand in the treatment of bone metastases (Supported
by an education grant from Amgen)
Dr. Christine
Simmons Insert #3 February 2010
Treatment of chronic lymphocytic leukemia (CLL) in the untreated patient (Supported by an education grant from Roche)
Dr. Martina Trinkaus
Vol 12, Issue 2 May 2010
From the guest editor‘s desk Ms. Lori Holden
Running care team meetings: A primer! Mr. Blair Henry
Providing person-centred cancer care Dr. Margaret Fitch
Predictors of place of death and family caregiver burden across the home-based palliative care trajectory
Drs. Denise Guerriere, Peter Coyte, Amna Husain, Denise Marshall
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Current research on normal and complicated/prolonged grief Dr. Mary Vachon Insert May 2010
Stereotactic body radiotherapy for liver metastases
Surgical resection of colorectal liver metastases: An update (Supported by an education grant from Roche)
Dr. Hans Chung
Dr. Calvin Law
Vol 12, Issue 3 August 2010
From the associate editor‘s desk Dr. Cyril Danjoux
Humane end-of-life treatment conversations Dr. Monica Branigan
New trend: Survivorship care Dr. Margaret Fitch
Dysphasia and pill-taking in the oncology setting Dr. Carlo DeAngelis
2010 Annual Hospice Palliative Care Conference Ms. Florencia Jon
Panic in cancer patients: ―Fight or flight‖ Dr. Eileen La Croix
Sunny side up Mr. Matthew Mendonca
Insert #1 August 2010
Breakthrough cancer pain: Assessment and management challenges
(Supported by an education grant from Valeant Canada Ltd.)
Dr. Lawrence Librach
Vol 12, Issue 4 November 2010
From the editor‘s desk Dr. Edward Chow
Mitigating health care communication barriers: A legal, ethical and economic case for professional medical interpreters
Ms. Sally Bean
Palliative end-of-life home care and Chinese immigrants: The meaning of home and negotiations of care
Drs. Lisa Seto, Jan Angus, Doris Howell, Denise Gastaldo, and Amna Husain
Having and getting more life Dr. Michele Chaban
Opioid-induced hyperalgesia: When more is less Dr. Carlo DeAngelis
The multi-dimensional role of the clinical nutrition team at the Odette
Cancer Centre
Ms. Rosie Benson,
Elaine Posluns, Tracey Rapier, Edith Stokes, and Pauline Wisdom-Gilliam
Insert #1 November 2010
Treatment of chronic lymphocytic leukemia in the elderly
(Supported by an education grant from Roche)
Dr. Matthew Cheung
Insert #2 November 2010
HER2 testing and trastuzumab in advanced gastric and gastroesophageal cancer (Supported by an education grant from Roche)
Drs. Eugene Hsieh, Yoo-Joung Ko
Insert #3 November
2010
Cancer-associated venous thromboembolism NCCN clinical practice
guidelines – Update 2010 (Supported by an education grant from Pfizer)
Dr. Richard Jay
Insert #4 November 2010
Systemic therapy for metastatic Renal Cell Carcinoma (mRCC) (Supported by an education grant from Novartis)
Drs. Sonal Gandhi, Georg Bjarnason
Vol 13, Issue 1 February 2011
From the guest editor‘s desk Dr. Arjun Sahgal
Facilitating parental competencies in the face of cancer Ms. Denis Bilodeau
Children‘s resources Ms. Julie Burnett
Ultrasound therapy for bone metastases
Drs. Kristopher
Dennis, Greg Czarnota
It takes a village
Mr. Stephen Jenkinson
Wading through the questions: A journey into bioethics Ms. Rosanna Macri
Continuing Medical Education 2011 Dr. Ewa Szumacher Insert #1 February 2011
Rapidly changing landscape of systemic therapy for castration-resistant prostate cancer (Supported by an educational grant from Sanofi-Aventis)
Dr. Urban Emmenegger
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Vol 13, Issue 2
May 2011 From the guest editor‘s desk Dr. May Tsao
Hot Spot congratulates Dr. Andrew Smith on his appointment as the new
Chief, Odette Cancer Centre and Regional Vice-President, Cancer Care Ontario
Motivational interviewing as a tool for smoking cessation intervention in
the oncology setting
Ms. Shannon Furey
Disclosure delayed Dr. Phillip C Hébert
Patient‘s perspectives about communication with health care providers Drs. Grace Ma, Amna Husain Mr. Christopher
Obwanga
Spirituality in advanced cancer Dr. Mary Vachon
Continuing Medical Education 2011-2012 Dr. Ewa Szumacher Insert #1 May 2011
Meeting the challenges of opioid-induced constipation (OIC) (Supported by an educational grant from Merck)
Dr. Erica L Weinberg
Insert #2 May 2011
Cutaneous T-cell lymphoma: A spectrum of disease and treatments
(Supported by an educational grant from Merck)
Dr. Neil H. Shear
Vol 13, Issue 3 August 2011
From the guest editor‘s desk Dr. Toni Barnes
Odette Cancer Research Program welcomes new director
Hot Spot congratulates our colleagues
Medical error and it impact on staff Mr. Blair Henry
Preventing Radiotherapy-Induced Pain Flare with Dexamethasone Dr. Kristopher Dennis
Psychology‘s Role in the Post-Treatment Period Ms. Pat Brown Dr. Karen Fergus
Stereotactic radiotherapy for oligometastases: An evolving treatment option and new clinical trial at Sunnybrook Odette Cancer Centre
Dr. Patrick Cheung
Distress is the sixth vital sign Dr. Margaret Fitch
Continuing Medical Education 2011-2012 Dr. Ewa Szumacher Insert #1 August 2011
Fentanyl for breakthrough cancer pain (BTCP) (Supported by an educational grant from Paladin)
Dr. Carlo DeAngelis
Insert #2 August 2011
Latest advances in the treatment of Pancreatic neuroendocrine tumor (Supported by an educational grant from Pfizer)
Dr. Simron Singh
Vol 13, Issue 4 November 2011
From the guest editor‘s desk Dr. Cyril Danjoux
Sunnybrook doctor named Ontario‘s Family Physician of the Year
Advice from the pharmacist Dr. Mark Pasetka
I had breast cancer surgery—Why can‘t I move my arm normally? Ms. Amanda Smart
Mindfulness in ethics Dr. Monica Branigan
Happiness! Ms. Michele Chaban
The impact of Camp Erin on Bereaved children Ms. Heather O‘Brien
Continuing Medical Education 2011-2012 Dr. Ewa Szumacher Insert November 2011
New treatments improve quality of life and survival in castrate-resistant prostate cancer
Dr. Andrew Loblaw
Vol 14, Issue 1 February 2012
From the editor‘s desk Dr. Edward Chow
Congratulations to Dr. Carlo DeAngelis
Who gets access to care? Ethical obligations and the uninsured patient Ms. Sally Bean
When to refer to palliative care: Distinguishing between the field of palliative care and palliative care related clinical competencies
Dr. Jeff Myers
Photodynamic therapy (PDT) for vertebral metastases: A prospective phase I clinical trial
Dr. Albert Yee
Management of hand-foot syndrome Ms. Angie Giotis
Continuing Medical Education 2012-2013 Dr. Ewa Szumacher
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Insert #1 February 2012
Stereotactic body radiotherapy for liver metastases (Supported by an educational grant from Roche)
Dr. Hans Chung
Insert #2 February 2012
Angiogenesis as a target in treating non-small cell lung cancer (NSCLC) (Supported by an educational grant from Boehringer-Ingelheim Canada)
Dr. Susanna Cheng
Vol 14, Issue 2 May 2012
From the editor‘s desk Dr. Edward Chow
Resource allocation during a drug shortage Ms. Sally Bean
What is a ―speech therapist‖ doing in a cancer centre? Dr. Marlene Jacobson
New hope for patients with a limited number of brain metastases Dr. Arjun Sahgal
Opioid prescription after pain assessment: A population-base cohort of elderly patients with cancer
Dr. Lisa Barbera
The mindful, compassionate professional Dr. Mary Vachon
Continuing Medical Education 2012-2013 Dr. Ewa Szumacher Insert May 2012
Quality of life assessment in lung cancer clinical trials (Supported by an educational grant from Boehringer-Ingelheim Canada)
Mr. Liang Zeng Dr. Edward Chow
Vol 14, Issue 3 August 2012
From the guest editor‘s desk Dr. May Tsao
Why is a ―culture of caring‖ important to the future of health care? Ms. Karen Faith
Combined resection of intra- and extra-hepatic metastases of colorectal cancer (CRC): A phase II trial
Dr. Natalie Coburn
Health intelligence (HQ): Promoting health and wellness in health care Dr. Michele Chaban
Palliative radiotherapy for Merkel cell carcinoma Dr. Luluel Khan Dr. Elizabeth Barnes
Continuing Medical Education 2012-2013 Dr. Ewa Szumacher Insert #1 August 2012
Hormone receptor positive metastatic breast cancer
(Supported by an educational grant from AstraZeneca Canada Inc.)
Dr. Sunil Verma
Insert #2 August 2012
Evolving issues in the use and prescribing of opioids for cancer pain (Supported by an educational grant from Purdue Pharma)
Dr. Erica Weinberg
Vol 14, Issue 4 November 2012
From the guest editor‘s desk Dr. Toni Barnes
2012 Guidelines for the management of malignant epidural spinal cord compression
Dr. Andrew Loblaw
Preventative ethics, advanced directives, normalization – and Blairsville Mr. Blair Henry
Addressing smoking cessation with our patients: It is all of our responsibility
Mr. Leslie Gibson
The mind matters in cancer: Emerging evidence Dr. Mary Vachon
Meaningful change in oncology quality of life instruments Ms. Gillian Bedard Dr. Liying Zhang Dr. Edward Chow
Continuing Medical Education 2012-2013 Dr. Ewa Szumacher Insert November 2012
More progress in advanced prostate care: An update of the management of castrate-resistant prostate cancer (Supported by an educational grant from Janssen Inc.)
Dr. Andrew Loblaw
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APPENDIX F [Back]
Undergraduate Teaching – Co-op Program
Programme Student Period
Fourth year student
University of Waterloo
Liang Zeng 2010-2012
Fourth year student
University of Waterloo
Kaitlin Koo 2010-2012
Third year student
University of Waterloo Emily Chen 2011-2012
Third year student
University of Waterloo Nemica Thavarajah 2011-2012
Third year student
University of Waterloo Michelle Zhou 2011-2012
Second year student
McMaster University Gemma Cramarossa 2011-2012
Third year student
Queen‘s University Michael Poon 2012
Second year student
McMaster University Rehana Jamani 2011-2012
Second year student
University of Waterloo Gillian Bedard 2012
Second year student
University of Waterloo Erin Wong 2012
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APPENDIX G
[Back]
Ongoing Research Studies in the Rapid Response Radiotherapy Program and the Bone Metastases Clinic
Study Titles
Aprepitant and Granisetron for the prophylaxis of radiation induced nausea and vomiting (RINV) – A Phase II Study
Development of a Canadian-Led International Bone Metastases Module to
Accompany European Organization for Research and Treatment of Cancer Quality of Life Group Core Questionnaire (the EORTC QLQ-C30) for Future
Clinical Trials in Patients with Bone Metastases
Examining the acute toxicities of conventional external beam radiotherapy in the treatment of lung metastases or advanced lung cancer
OnsolisTM (Fentanyl citrate buccal soluble film) for control of incident pain in
patients with bone metastases referred for palliative radiotherapy: A pilot
study
Patterns of Practice Among Radiation Oncologists in the Prophylaxis of Radiation-Induced Nausea and Vomiting – An International Survey (RINV)
SC-20 A Phase III International Randomized Trial of Single Versus Multiple
Fractions for Re-irradiation of painful bone metastases (NCIC Clinical Trials Group)
SC-20U Effect of Re-Irradiation for bone pain on Urinary Markers of
Osteoclast Activity --A companion study to SC 20
SC-23 A Phase III Double-Blind Study of Dexamethasone Versus Placebo in the Prophylaxis of Radiation-Induced Pain Flare Following Palliative
Radiotherapy for Bone Metastases (NCIC Clinical Trials Group)
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APPENDIX H: Report Submission for Knowledge Translation Casebook (in association with Ontario Institute for Cancer Research, Canadian Partnership Against Cancer,
and McMaster University Health Sciences)
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APPENDIX I
Emily Sinclair Written by Mark Hayes
Chances are you don't know what a Radiation Therapist does. Some people might envision a nurse that takes x-rays or perhaps (if you’re into science fiction), a cross between Darth Vader and Dr. Fraser Crane. According to the National Cancer
Institute, “Radiation therapy is the treatment of cancer and other diseases with ionizing radiation.” The therapist works with doctors, patients and all members of the hospital team to strategize and implement the destruction of malignant cells.
Emily Sinclair has been waging war on cancer for over 20 years. She graduated with a DCR(T) from the School of Radiotherapeutics and Oncology in Glasgow, Scotland. Shortly after graduation, Emily was headhunted by the Canadian Government, as Emily explains, "The wait list for cancer treatment in Canada was too high, so they sent scouts all around the world to bring in new talent." They offered Emily a one year contract and an exciting opportunity to move to a new country and put her new skillset to work. It's been over twenty years and she's still here.
Emily works as a radiation therapist at the Odette Cancer Centre in Toronto's Sunnybrook Hospital. On any given day, she can find herself doing anything from calculating the radiation dose and planning the patient’s treatment, preparing an isodose distribution to spare as much healthy tissue as possible, counselling patients and their families, or treating patients with the high-tech radiation
equipment with names that are near impossible to pronounce. Her role in the patient’s recovery is absolutely essential — remember, the doctor sees a patient once every two weeks, whereas Emily deals with them every day for 6 weeks straight.
Emily is the recipient of multiple awards, but perhaps the most prestigious is a recent Academic Appointment at the University of Toronto's Department of Radiation Oncology within the Faculty of Medicine. She was awarded this honour for her significant contribution and dedication to her field of study; as a result, she contributes to the world of academia by writing manuscripts and lecturing both locally and across the world.
Aside from the obvious challenges Emily faces on a daily basis, she wants to raise awareness to difficulties facing her discipline at large, stating, “The salaries aren’t great, but our qualifications have to be.” Most radiation therapists have at least 7 years of post-secondary education under their belt, but their pay levels don’t represent two degrees, “Many good Radiation Therapists move on to drug companies or medical tech manufacturers — we can’t compete with the salaries they offer.” Through Emily’s efforts with the Canadian Association of Medical Radiation Technologists (CAMRT) and her union the Professional Institute of the Public Service of Canada (PIPSC), she fights for the strength of her profession which ultimately contributes to the betterment of public health and society at large.
http://www.ottawalife.com/index.php?option=com_content&view=article&id=465:emily-
sinclair&catid=74:public-service&Itemid=100018
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APPENDIX J
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