NeuroJeopardy Final NeuroJeopardy Final CountdownCountdown

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Don’t bringme down

Nobody’s Crazy here

Give me Those drugs

Memories Please

Don’t sing the Theme from CATS

I seeDinosaurs

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Final JeopardyFinal Jeopardy

1 - $1001 - $100 Depressed people often report Depressed people often report

disturbances in this vegetative behavior disturbances in this vegetative behavior ((disturbances of a person's functions necessary to maintain life)

SleepSleep

1 - $2001 - $200 Depressed individuals who receive Depressed individuals who receive

psychotherapy are MORE or LESS likely to psychotherapy are MORE or LESS likely to relapse than individuals on antidepressants relapse than individuals on antidepressants alone?alone?

Patients receiving psychotherapy in Patients receiving psychotherapy in addition to antidepressants are LESS likely addition to antidepressants are LESS likely to relapseto relapse

1 - $3001 - $300 State true or false to the followingState true or false to the following Depression is more common in women than Depression is more common in women than

menmen In depressed people the left hemisphere is In depressed people the left hemisphere is

less activated than expectedless activated than expected

TrueTrue TrueTrue

1 - $4001 - $400 Becoming depressed after giving birth to Becoming depressed after giving birth to

a child is know as?a child is know as?

Postpartum depressionPostpartum depression

1 - $500 1 - $500 Bonus Question- If medications for depression Bonus Question- If medications for depression

begin exerting effects soon after the patient begin exerting effects soon after the patient takes the medication, why does it take weeks or takes the medication, why does it take weeks or months to see an effect on mood and behavior?months to see an effect on mood and behavior?

Did you think I was just going to Did you think I was just going to give give you the you the answer?answer?

Changes have to be made by intercellular and Changes have to be made by intercellular and intracellular mechanism which will involve intracellular mechanism which will involve genes and the proteins they producegenes and the proteins they produce

2 - $1002 - $100 Depression which regularly occurs during Depression which regularly occurs during

a particular season is known as ______?a particular season is known as ______? Where does this phenomenon most often Where does this phenomenon most often

occur?occur?

SAD or seasonal affective disorderSAD or seasonal affective disorder Closer to the poles (farther away from the Closer to the poles (farther away from the

equator)equator)

2 - $2002 - $200 Someone with bipolar depression Someone with bipolar depression

alternates between what two states?alternates between what two states?

Mania and DepressionMania and Depression

2 - $3002 - $300 What is Korsakoff’s syndrome? What is Korsakoff’s syndrome? Who is most likely to develop the syndrome?Who is most likely to develop the syndrome? What is a unique symptom of the syndrome What is a unique symptom of the syndrome

which we discussed in classwhich we discussed in class

chronic memory disorder caused by severe deficiency of thiamine (vitamin B-1). Korsakoff syndrome is most commonly caused by alcohol misuse

Long time alcoholics Confabulation

2 - $4002 - $400 What drug is commonly prescribed for What drug is commonly prescribed for

bipolar disorder? bipolar disorder? Why should you be very careful to monitor Why should you be very careful to monitor

its levels in the bloodits levels in the blood

LithiumLithium Because lithium has a very narrow Because lithium has a very narrow

therapeutic window of functioning and can therapeutic window of functioning and can become toxic if levels rise too muchbecome toxic if levels rise too much

2 - $5002 - $500 What is the most common side effect for ECT What is the most common side effect for ECT

(electroconvulsive therapy)(electroconvulsive therapy)

Patients complain of memory lossPatients complain of memory loss

3 - $1003 - $100 What category of antidepressant What category of antidepressant

medications work by preventing the medications work by preventing the presynaptic neuron from reabsorbing 5-HT presynaptic neuron from reabsorbing 5-HT after it is released?after it is released?

SSRIsSSRIs

3 - $2003 - $200 SSRIs operate similarly to what other class of SSRIs operate similarly to what other class of

drugs (i.e. they have a similar mechanism of drugs (i.e. they have a similar mechanism of action)action)

Bonus question-Which is the more effective Bonus question-Which is the more effective medication of the two?medication of the two?

TCA (tricyclics)TCA (tricyclics) Interesting question; Let’s look below for the answerInteresting question; Let’s look below for the answer Ha! Trick question SSRIs are not more effective and Ha! Trick question SSRIs are not more effective and

imipramine (TCA) is still the gold standardimipramine (TCA) is still the gold standard

3 - $3003 - $300 Name the four major categories of

antidepressants as discussed in class

Tricyclics (TCAs), MAOIs, SSRIs and Tricyclics (TCAs), MAOIs, SSRIs and Atypical antidepressantsAtypical antidepressants

3 - $4003 - $400 Before the advances of more recent work Before the advances of more recent work

in psychopharmacology, how were many in psychopharmacology, how were many medications or drugs discovered?medications or drugs discovered?

Trial and error, accidentTrial and error, accident

3 - $5003 - $500

What is the mechanism of action of What is the mechanism of action of most antipsychotic medicationmost antipsychotic medication

Blockage of Dopamine (DA) receptorsBlockage of Dopamine (DA) receptors

4 - $1004 - $100 _______ memory has limited capacity while _________ is said to have unlimited capacity

STM (short term memory), LTM STM (short term memory), LTM

4 - $2004 - $200 Whenever you watch a scary movie you always Whenever you watch a scary movie you always

eat chocolate covered raisins. After a while just eat chocolate covered raisins. After a while just seeing chocolate covered raisins makes you seeing chocolate covered raisins makes you scared. In this classical paradigm 1) What is the scared. In this classical paradigm 1) What is the movie? 2) What are the chocolate covered movie? 2) What are the chocolate covered raisins? 3) What is the feeling of being scared?raisins? 3) What is the feeling of being scared?

Unconditioned stimulusUnconditioned stimulus Conditioned stimulusConditioned stimulus Unconditioned response (and CR)Unconditioned response (and CR)

4 - $3004 - $300 Forgetting events prior to brain injury is Forgetting events prior to brain injury is

_____amnesia while being unable to form _____amnesia while being unable to form new memories after a brain injury is new memories after a brain injury is ______amnesia______amnesia

Retrograde, anterogradeRetrograde, anterograde

4 - $4004 - $400 The ability to state a memory in words is The ability to state a memory in words is

known as ______memory while the ability known as ______memory while the ability to perform a certain skill or task is known to perform a certain skill or task is known as ______memoryas ______memory

Declarative, ProceduralDeclarative, Procedural

4 - $5004 - $500 Karl Lashley looked for a physical basis of Karl Lashley looked for a physical basis of

memory which he called the _____. He also memory which he called the _____. He also stated two principles known as ________ stated two principles known as ________ and _______and _______

EngramEngram EquipotentialityEquipotentiality Mass ActionMass Action

5 - $1005 - $100 What structural defect of the brain is often What structural defect of the brain is often

seen in schizophrenia?_____seen in schizophrenia?_____ Is this or some other structural defect seen Is this or some other structural defect seen

in the majority of cases of schizophrenia?in the majority of cases of schizophrenia?

Ventricular EnlargementVentricular Enlargement NoNo

5 - $2005 - $200 In Schizophrenia an example of a positive In Schizophrenia an example of a positive

symptom would be_____ while an example of symptom would be_____ while an example of a negative symptom would be______a negative symptom would be______

Hallucinations or DelusionsHallucinations or Delusions Social Isolation or Flat affect, or Anhedonia Social Isolation or Flat affect, or Anhedonia

5 - $3005 - $300 What is the concordance ratio for monozygotic What is the concordance ratio for monozygotic

(identical twins) for schizophrenia?(identical twins) for schizophrenia? What are some of the causes of schizophrenia What are some of the causes of schizophrenia

as discussed in class?as discussed in class?

50%50% Genetics, Environment, Viral Hypothesis, Genetics, Environment, Viral Hypothesis,

Migration of neurons in the hippocampus, Migration of neurons in the hippocampus, Toxins, Drugs, Shoe Size, Owning a dog, Toxins, Drugs, Shoe Size, Owning a dog, Orange Juice-pretty much whatever you want Orange Juice-pretty much whatever you want

5 - $4005 - $400 A single gene has been identified that accounts A single gene has been identified that accounts

for all cases of schizophrenia True or Falsefor all cases of schizophrenia True or False Childhood schizophrenia is considered common Childhood schizophrenia is considered common

True or FalseTrue or False

FalseFalse FalseFalse

5 - $5005 - $500 In making a differential diagnosis of In making a differential diagnosis of

schizophrenia what is essential for you to schizophrenia what is essential for you to dodo

Rule out any other medical or related Rule out any other medical or related conditions which may account for the conditions which may account for the symptomssymptoms

Final JeopardyFinal Jeopardy Long Term Potentiation begins by stimulating the____ Long Term Potentiation begins by stimulating the____

receptor and then expels the ____ion out of the receptor and then expels the ____ion out of the ______receptor site which allows ___ and ___ions to enter ______receptor site which allows ___ and ___ions to enter the _____ receptor. Ultimately the signal cascades ends the _____ receptor. Ultimately the signal cascades ends in the nucleus where new _____ are createdin the nucleus where new _____ are created

Why should I tell you?Why should I tell you? AMPA, Magnesium, NMDA, Calcium and AMPA, Magnesium, NMDA, Calcium and

Sodium, NMDA, proteinsSodium, NMDA, proteins