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Blattman,JN 1January20171

Joseph N Blattman, Ph.D. Assistant Professor, Arizona State University

A320F, 1001 S. McAllister St, Tempe AZ 85287 Phone: (480) 965-2909 Email: [email protected]

Education Postdoctoral Training, Immunology, University of Washington, Seattle, WA 2001-2005 Advisor: Dr. Philip D. Greenberg, MD Ph.D., Immunology and Molecular Pathogenesis, Emory University, Atlanta, GA 2001 Advisor Dr. Rafi Ahmed, PhD B.S. with Distinction, Biochemistry, University of Nevada, Reno, NV 1996 Advisor Dr. Stephen C. St Jeor, PhD

Professional Appointments Founder & Chief Scientific Officer, Gemneo Bioscience, Inc. 2016-current Assistant Professor, School of Life Sciences & Biodesign Center for Immunotherapy, 2011-current Vaccines, & Virotherapy, Arizona State University, Tempe, AZ Visiting Research Assistant Professor, Department of Immunobiology 2011 King’s College, London, England Affiliate Investigator, Vaccine and Infectious Disease Division 2010-2011 Fred Hutchinson Cancer Research Center, Seattle, WA Research Affiliate, Primate Immunology Core Laboratory 2008-2011 Washington National Primate Research Center, Seattle, WA Affiliate Investigator, Program in Immunology, Clinical Research Division 2007-2011 Fred Hutchinson Cancer Research Center, Seattle, WA Research Assistant Professor, Department of Immunology, School of Medicine 2006-2011 University of Washington, Seattle, WA Research Associate, Program in Immunology, Clinical Research Division 2005-2007 Fred Hutchinson Cancer Research Center, Seattle, WA Acting Instructor, Department of Immunology, School of Medicine 2005-2006 University of Washington, Seattle, WA

Honors & Awards AAAS Alan I. Leshner Leadership Institute Public Engagement Fellowship, Nominee 2016 American Association of Immunologists Careers in Immunology Fellowship 2016-2017 European Academy for Tumor Immunology 2016 Lincoln Center for Applied Ethics Faculty Fellow 2016-2017 President, American Society for Microbiology, AZ/Southern NV Chapter 2016-2017 President-Elect, American Society for Microbiology, AZ/Southern NV Chapter 2015-2016 Centennial Professorship Award, Associated Students of Arizona State University 2015 Teaching Excellence and Innovation Award, ASU Undergraduate Programs 2015 Zebulon Pearce Distinguished Teaching Award, Nominee 2015 Honor’s Faculty, Barrett, The Honor’s College, Arizona State University 2014-current Teaching Innovations Award, School of Life Sciences, Arizona State University, Nominee 2014 International Society for Biological Therapy of Cancer, Team Science Award (UW/FHCRC) 2010 NIH Howard Temin Career Development Award 2006-2011 NIH Clinical Research Loan Repayment Program Recipient 2004-2007 AAAS/Science Program for Excellence in Science, Nominee 2004 Cancer Research Institute/James E. Siegel Perpetual Fellowship Award 2002-2005 American Cancer Society Post-Doctoral Fellowship (awarded, not accepted) 2002 UW Immunology Department Training Grant Fellowship (awarded, not accepted) 2002 ARCS Foundation Fellow, Nominee 1999 University of Nevada Board of Regents Presidential Scholarship 1989


Research Support Current: Duration Amount Status NIH SBIR AI089290-01 July 2016 – June 2019 $2.21M active/current PI: Bagley (Profectus Biosciences, Inc.), Sub-project I leader: Blattman A Novel Mucosal Adjuvant for an HIV DNA Vaccine We will test the in vivo efficacy of plasmid-based expression of dominant-positive retinoic acid receptor proteins and/or overexpression of retinaldehyde dehydrogenase enzymes to improve the mucosal homing properties and systemic responses of HIVgag specific T cells during DNA vaccination.

NIH R21-AI125827-01 July 2016 – June 2018 $410K active/current PI: Blattman DNA Origami Nanostructures for Single-Cell Multi-Gene Analysis without Single Cell Sorting Use of DNA origami nanostructures for intracellular capture of TCRa and TCRb mRNA, molecular linkage facilitated by the constrained geometry of the mRNA on individual DNA origami tiles, and analysis via high-throughput next-generation sequencing to obtain the TCR repertoire of lymphocyte populations without the need for single cell sorting.

NIH IMAT R21-CA196460-01 Sept 2015 – Aug 2018 $760K active/current PI: Anderson (ASU), Co-PI: Blattman Single Cell Analysis of Tumor Heterogeneity without Single Cell Sorting Use of DNA origami nanostructures for intracellular capture of cancer driver/co-driver mRNA, molecular linkage facilitated by the constrained geometry of the mRNA on individual DNA origami tiles, and analysis via high-throughput next-generation sequencing to obtain the diversity of tumor cells during cancer progression.

NIH R01-AI110720-02 April 2014 – March 2019 $1.87M active/current PI: Antia (Emory University), Co-PI: Blattman Understanding Vaccine-Induced T Cell Mediated Immunopathology During Virus Infection Use of quantitative mathematical models to make predictions regarding which virus or immune response variables contribute to pathology versus protection during virus infection. Model predictions and estimated parameters are experimental validated via in vivo animal models.

Lincoln Center for Applied Ethics Faculty Fellows Program PI: Blattman June 2016 – May 2017 $23K active/current South and Central American Research Collaboration for Emerging Infectious Diseases Administrative support through the ASU Lincoln Center for Applied Ethics for design and implementation of ethical collaborations with Central and South American researchers to improve responses to emerging infectious diseases.

American Association of Immunologists Careers in Immunology Fellowship PI: Blattman Sept 2016 – Aug 2017 $23K active/current Award to support research by a graduate trainee (Louis Schoettle) in immunology.

Pending: Proposed Duration Amount Status NIH R01 AI125256-01 June 2017 – May 2022 $1.97M pending (scored at 13th%ile) PI: Yan (ASU), Co-PI: Blattman Single Cell BCR Analysis from Heterogeneous Cell Populations Without Single Cell Sorting Use of DNA origami nanostructures for intracellular capture of IgH + IgL mRNA, molecular linkage facilitated by the constrained geometry of the mRNA on individual DNA origami tiles, and analysis via high-throughput next-generation sequencing to obtain the therapeutic antibodies without the need for single cell sorting.

NIH SBIR Phase I Oct 2017 – May 2017 $150K submitted Jan 2017 PI: Blattman (submitted from Gemneo Bioscience, Inc.) Single Cell Gene Chips Business Development Construction, optimization and marketing analysis of DNA origami nanochips for single cell sequence analysis of human T lymphocyte TCRα and TCRβ sequences.

Planned: Proposed Duration Amount Status St Baldrick’s Foundation July 2017 – June 2018 $100K in preparation PI: Hingorani (PCH), Co-PI: Blattman Combination of Virotherapy with Blockade of Programmed Death Receptor Pathways as a Therapeutic Strategy in Metastatic Osteosarcoma Efficacy of Myxoma virus oncolytic virus therapy to enhance PD-L1/CTLA-4 blockade for eradication of metastatic osteosarcoma in preclinical models .


Completed (ASU): Duration Amount Status Hyundai Hope on Wheels July 2014 – Dec 2015 $80K completed PI: Hingorani (PCH), Co-PI: Blattman Blockade of Programmed Death Receptor Pathway as a Therapeutic Strategy in Osteosarcoma

Biodesign Advancing Research Innovations and Translational Outcomes by Stimulating Focused Multi-Center Research Initiatives Mar 2014 – Feb 2015 $200K completed PI: Blattman Rapid Identification of TCR for Generation of Chimeric Antigen Receptors for T Cell Therapy

Virginia G Piper Bridging Award April 2012 – Dec 2012 $63 K completed PI: Blattman A Direct Measure of TCRαβ Combinatorial Diversity

Profectus Biosciences, Inc. Jan 2012 – Dec 2012 $20K completed PI: Bagley (Profectus), Sub-contract: Blattman Increased Biosynthesis of Retinoic Acid as a Strategy to Enhance Mucosal Homing Properties of DNA-Vaccine Induced T cell Responses. Completed (UW): Duration Amount Status FHCRC IDS / UW Virology Division July 2010 – Dec 2011 $100K completed PI: Blattman “Proof-of-Concept” Study to Link Immununologic and Epidemiologic Measures of HSV-2 Vaccine Efficacy

NIH/NIAID P01 AI27757-17 June 2009 – May 2011 $350K completed Center for AIDS Research (CFAR PI: K. Holmes) Supplementary Project I PI: Blattman Broadening T Cell Responses During HIV Vaccination.

Bill and Melinda Gates Foundation June 2006 – May 2011 $9.99M completed PI: Greenberg, Co-PI: Blattman Defining and Comparing Immunogenicity and Improving Activity of Vaccines by Developing and Employing Novel Mouse Models.

NIH K01 CA117985-01 July 2006 – June 2011 $720K completed PI: Blattman Enhancing CD8 T Cell Function by Abrogating Inhibition by Regulatory Proteins.

Cancer Research Institute July 2002 – June 2005 $130K completed James E. Siegel Perpetual Post-Doctoral Fellowship Award PI: Blattman Enhancing the Survival and Efficacy of Adoptively Transferred CD8 T Cells during Immunotherapy of Viral Infection and Tumors. Research Interests Overview of research: The overall goal of the research in my laboratory is to understand how T cells recognize antigens presented on MHC proteins, to define ways to improve T cell responses during vaccination or therapeutic interventions, to model and test the consequences of T cell responses during viral infection in individual hosts as well as in populations, and to develop new strategies for improving T cell control of viral infections and tumors.

Specific Research Areas: T cell receptor (TCR) diversity – In order to recognize and combat a diverse array of invading pathogens, T cells express a large repertoire of clonotypic αβ dimeric T cell receptors (TCR), with few cells on average expressing TCR specific for any given antigen but an enormous number of specificities at the population level within an individual. Accurately estimating total TCR diversity is problematic, as this is a function of both the CDR3 diversity within each TCR chain due to recombination between V, D, and J gene segments, and P- and N-nucleotide addition or deletion at gene segment joints, as well as diversity due to pairing of different TCRα and TCRβ chains. Current methods for obtaining both TCRα and TCRβ CDR3


sequences from individual cells in large populations are unfeasible; single cell sorting is too expensive and molecular strategies have not been adequately developed. We have developed DNA origami nanostructures that can be transfected into T cells to capture and protect both TCR mRNA, as well as molecular techniques for linking these CDR3 into a single cDNA for paired-end high-throughput next-generation sequencing. We have begun to apply the DNA origami approach for quantitating cellular diversity to cancer in order to refine clinical therapy approaches. Key collaborators: Dr. Hao Yan (ASU) – design and construction of DNA origami nanostructures, Co-holder of US provisional patent. Dr. Karen Anderson (ASU) – application of DNA origami approach to tumor heterogeneity

T cell responses to vaccination – CD8 T cell responses are important for the control of a number of human and animal pathogens at the portal(s) of entry, as well as providing systemic immunity after infection. We are currently evaluating a number of different strategies for selectively targeting vaccine-induced T cell responses to mucosal sites as a means of improving containment at the portal of entry. However, narrowly focused CD8 T cell responses are insufficient to either provide coverage for the large number of circulating strains of some viruses or to prevent selection of mutant viruses after infection that are able to evade CTL recognition. We seek to understand what limits the generation of T cell responses to sub-dominant epitopes, and conversely what facilitates responses to immunodominant epitopes by systematically analyzing the efficiency of generation and stability of epitopes from protein substrates and how these parameters change in different antigen-presenting cell types (including direct and cross-presentation. The data from these studies can then be used to predict which epitopes from an immunogen will be immunodominant after vaccination, to design immunogens to increase the levels of subdominant epitopes on the cell surface as a means of improving responses to these epitopes, and to selectively target public T cell precursors that are present in the naïve repertoire such that a majority of individuals will be able to generate broader responses. Key collaborators: Dr. Linda Klavinskis (King’s College, London) – analysis of epitope hierarchy and cross-presentation pathways Dr. Karen Anderson (ASU) – prediction immunogenic T cell epitopes based on hydrophobicity Dr. Ken Bagley (Profectus Biosciences,Inc) – provision of reagents for improving mucosal T cell responses

Linking immunologic and epidemiologic measures of vaccine efficacy – Vaccination remains one of the most potent strategies for preventing human diseases caused by pathogens. The empirical approach to vaccine development, employing attenuated versions of pathogens or subunit vaccines has resulted in protective efficacy against a number of viral and bacterial pathogens. However, relatively modest subsequent progress has been made in the improvement of empirically defined vaccines or in the development of new, efficacious vaccines. This is in part due to an incomplete quantitative understanding of the immunological mechanisms that are required to reduce susceptibility to infection, disease pathogenesis, or subsequent transmission. We are using animal models of vaccination and viral infection to explicitly link vaccine-induced immunological responses with epidemiological measures of vaccine efficacy including reduction in susceptibility, disease, and subsequent transmission. This will allow us to develop a quantitative framework for understanding how immunological responses induced by certain types of vaccines might provide protection against infection and/or disease during subsequent pathogen exposure. Key collaborators: Dr. Rustom Antia (Emory University) –immunological and epidemiological model development Dr. Ira Longini (University of Florida) – epidemiologic analysis of vaccine efficacy, model linkage Dr. Carlos Castillo-Chavez (ASU) – epidemiologic model simulations and refinement Immunotherapy of Persistent Viral Infection and Metastatic Cancer – During prolonged antigen stimulation, as occurs during persistent viral infection or prolonged tumor burden, T cell responses become silenced as a means of preventing pathology to the host. However, in some viral infection and cancer settings, it is desirable to “reactivate” these T cells in order to provide additional protection. We are using persistent viral infection and cancer models to understand the molecular interactions that program T cell exhaustion in order to develop strategies for improving therapeutic approaches. Using both immune checkpoint blockade and metabolic approaches, we have developed new avenues for therapy of refractory tumors and persistent viral infection. Key collaborators: Dr. Pooja Hingorani (Phoenix Children’s Hospital) – provision of human osteosarcoma tumor samples Dr. Rachael Srianni (Barrow Neurological Institute) – development of nanostructure approaches for glioblastoma immunotherapy Dr. Adrienne Scheck (Barrow Neurological Institute) – ketogenic diet studies to improve immunity to metastatic glioma Publications Maroon text and star (✪) denotes members of the Blattman Laboratory at Arizona State University. Purple text and star (★) denotes members of the Blattman/Greenberg Laboratory at the University of Washington. Total citations for Blattman, JN:6817, h-index:26, m-quotient:1.41, i10-index:32

Peer-Reviewed Primary Research Journal Articles In Preparation • Schoettle LN✪, §Blattman JN (2017) The First Quantitative Analysis of Total TCR Diversity, Nature (in

preparation).


• Manhas K✪, §Blattman JN (2017) Cooperative binding between retinoid and rexinoid receptors to improve mucosal homing of T cells, Journal of Immunology (in preparation).

Submitted • Schoettle LN✪, You Z, Wei X, Reed AE✪, Yan H, §Blattman JN (2017) Single Cell Gene Chips for

Intracellular Capture of mRNA, Nature Nanotechnology (submitted). • Franco LS✪, Holechek SA✪, Caplan MR, §Blattman JN (2017) Sequence-Specific Detection of Different

Strains of LCMV Viruses in a Single Sample using Tentacle Probes, Virology (submitted). • McAfee MS✪, Johnson PLF, Zarnitsyna V, Antia R, §Blattman JN (2017) A Quantitative Understanding of the

Balance Between Pathologic and Protective Memory T Cell Responses During Viral Infection, Immunity (submitted).

• Holechek SA✪, Bruce CA✪, Contreras C, Nieves LM✪, Guzman VP✪, Towers S, McAfee MS✪, Carmen JM✪, Antia R, Castillo-Chavez C, §Blattman JN (2017) A Novel SIRC Ecological Model Incoporating both Horizontal and Vertical Transmission of Lymphocytic Choriomeningitis Virus, J Theor Biol (submitted).

• Meador LR, Kessans SA, Kilbourne J, Kibler KV, Pantaleo G, Esteban ME, Blattman JN, Jacobsb BL, Mor TS (2017) A heterologous prime-boosting strategy with replicating Vaccinia virus vectors and plant-produced HIV-1 Gag/dgp41 virus-like particles, Virology (submitted).

Published 1. Franco LS✪, Mujica V, Blattman JN, §Garcia AA, (2016) Successive Optimization of Homogeneous

Immunoassays Using Gold Nanoparticles for Antibody Detection, PLoS One (in press). 2. Holechek SA✪, McAfee MS✪, Nieves L✪, Guzman V✪, Manhas K✪, Bagley K, Fouts T, §Blattman JN (2016)

DNA Vaccination with Retinaldehyde Dehydrogenase 2 as a Molecular Adjuvant for Enhancement of Mucosal CD8 T Cell Immunity During DNA Vaccination, Vaccine 34(43):5629-5635.

3. Lussier DM✪~, Woolf EC~, Johnson JL✪, Brooks KS, Blattman JN, §Scheck AC (2016) Enhanced Immunity in a Model of Malignant Glioma is Mediated by a Therapeutic Ketogenic Diet, BMC Cancer 16:310.

4. McAfee MS✪, Hungh T, Johnson JL✪, Jacobs BJ, §Blattman JN (2015) Interaction Between Unrelated Viruses during Co-infection to Limit Pathology and Immunity, Virology 484:153-162.

5. Lussier DM✪, Johnson JL✪, Hingorani P, §Blattman JN (2015) Combination Immunotherapy with α-CTLA4 and α-PD-L1 Antibody Blockade Prevents Immune Escape and Leads to Complete Control of Metastatic Osteosarcoma, J ImmunoTher Cancer 3:21.

3. Chowell D, Krishna S, Becker PD, Cocita C, Shu J★, Tan X★, Greenberg PD, §§Klavinskis LS, §§Blattman JN, §§Anderson KS (2015) TCR Contact Residue Hydrophobicity is a Hallmark of Immunogenic CD8+ T Cell Epitopes, Proc Natl Acad Sci (USA) 112(14):E1754-1762.

4. Lussier DM✪, O'Neill L✪, Nieves LM✪, McAfee MS✪, Holechek SA✪, Collins AW, Dickman P, Jacobsen J, Hingorani P, §Blattman JN (2015) Enhanced T-Cell Immunity to Osteosarcoma Through Antibody Blockade of PD-1/PD-L1 Interactions, J Immunother 38(3):96-106.

5. Blattman NN, Lagunoff M, Blattman JN, §Corey L (2014) Nuclear Factor Kappa B is Required for the Production of Infectious Human Herpesvirus 8 Virions, Front Microbiol 5:129.

6. Zarnitsyna VI, Evavold BD, Schoettle LN✪, Blattman JN, §Antia R (2013) Estimating the Completeness, Redundancy and Cross-Reactivity of the T Cell Repertoire, Front Immunol 4:485.

7. Demidenko AA, Blattman JN, Blattman NN, Greenberg PD, §Nibert ML (2013) Engineering Recombinant Reoviruses with Tandem Repeats and a Tetravirus 2A-like Element for Exogenous Polypeptide Expression, Proc Nat Acad Sci (USA) 110(20):E1867-76.

8. Wegmann F, Gartlan KH, Harandi AM, Brinckmann SA, Coccia M, Hillson WR, Kok W-L, Cole S, Ho L-P, Lambe T, Puthia M, Svanborg C, Scherer EM★, Krashias G, Williams A, Blattman JN, Greenberg PD, Flavell R, Moghaddam A, §§Sheppard NC, §§Sattentau QJ (2012) Polyethyleneimine is a Potent Mucosal Adjuvant for Viral Glycoprotein Antigens, Nat Biotech 30(9):883-888.

9. Stromnes IM★, Fowler CC★, Blattman JN, Georgopolos C★, McAfee MS✪, Tan X★, §Greenberg PD (2012) Abrogation of Src Homology Region 2 Domain-Containing Phosphatase 1 in Tumor-Specific T Cells Improves Efficacy of Adoptive Immunotherapy by Enhancing the Effector Function and Accumulation of Short-Lived Effector T Cells In Vivo, J Immunol 189(4):1812-1825.

10. Schietinger A★, Delrow JJ, Basom RS, Blattman JN, §Greenberg PD (2012) Rescued Tolerant CD8 T cells are Preprogrammed to Reestablish the Tolerant State, Science 335(6069):723-727.


11. Tan X★, Sande JL★, Pufnock JS★, §§Blattman JN, §§Greenberg PD (2011) Use of Retinoic Acid as an Adjuvant to Imprint Mucosal Homing Properties to Vaccine-Induced T Cells, J Virol 85(16):8316-8327.

12. Johnson PLF, Kochin BF, McAfee MS✪, Stromnes IM★, Regoes RR, Ahmed R, Blattman JN, §Antia R (2011) Vaccination Alters the Balance between Protective Immunity, Exhaustion, and Pathology Following Disseminated Viremia, J Virol 85(11):5565-5570.

13. Rhee EG, Blattman JN, Kasturi SP, Kelley RP, Kaufman DR, Lynch DM, LaPorte A, Simmons NL, Clark SL, Pulendran B, Greenberg PD, §Barouch DH (2011) Multiple Redundant Innate Immune Pathways Contribute to the Immunogenicity of Recombinant Adenoviral Vectors, J Virol 85(1):315-323.

14. ~Stromnes IM★, ~Blattman JN, Tan X★, Jeevanjee S★, Gu H, §Greenberg PD (2010) Abrogating Cbl-b- in Effector CD8(+) T Cells Improves the Efficacy of Adoptive Therapy of Leukemia in Mice, J Clin Inv 120(10):3722-3734.

15. Fowler CC★, Pao L, §§Greenberg PD, §§Blattman JN (2010) SHP-1 in T Cells Limits the Production of CD8 Effector Cells Without Impacting the Formation of Long-lived Central Memory Cells, J Immunol 185(6):3256-3267.

16. Blattman JN, Wherry EJ, Ha SJ, van der Most RG, §Ahmed R (2009) The Impact of Epitope Escape on PD-1 Expression and CD8 T Cell Exhaustion During Chronic Infection, J Virol 83(9):4386-4394.

17. Wherry EJ, Ha SJ, Kaech SM, Haining WN, Sarkar S, Kalia V, Subramaniam S, Blattman JN, Barber DL, §Ahmed R (2007) Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection, Immunity 27(4):670-684.

18. Shin H, Blackburn S, Blattman JN, §Wherry EJ (2007) Viral Antigen and Extensive Division Maintain Virus-Specific CD8 T Cells During Chronic Infection, J Exp Med 204(4):941-949.

19. Wherry, EJ, Blattman JN, §Ahmed R (2005) Low CD8 T-cell Proliferative Potential and High Viral Load Limit the Effectiveness of Therapeutic Vaccination, J Virol 79(14):8960-8968.

20. Wherry EJ, Barber DL, Kaech SM, Blattman JN, §Ahmed R (2004) Antigen-Independent Memory CD8 T Cells do not Develop during Chronic Viral Infection, Proc Nat Acad Sci USA 101(45):16004-16009.

21. Zhang Y, Blattman JN, Kennedy NJ, Duong J, Nguyen T, Wang Y, Davis RJ, Greenberg PD, Flavell RA, §Dong C (2004) Regulation of Innate and Adaptive Immune Responses by MAP Kinase Phosphatase 5, Nature 430(7001):793-797.

22. van der Most RG, Murali-Krishna K, Lanier JG, Wherry EJ, Puglielli MT, Blattman JN, Zajac AJ, Sette AD, §Ahmed R (2003) Changing Immunodominance Patterns in Antiviral CD8 T cell Responses after Loss of Epitope Presentation or Chronic Antigen Stimulation, Virology 315(1):93-102.

23. Topp M, Riddell S, Akatsuka Y, Jensen MC, Blattman JN, §Greenberg PD (2003) Restoration of CD28 Expression in CD28-CD8+ Memory Effector T-cells Reconstitutes Antigen-Induced IL-2 Production, Brief Definitive Report, J Exp Med 198(6):947-955.

24. Blattman JN, Grayson JM, Wherry EJ, Kaech SM, Smith KA, §Ahmed R (2003) Therapeutic Use of IL-2 to Enhance Antiviral T-cell Responses In Vivo, Nat Med 9(5):540-547.

25. Wherry EJ, Blattman JN, Murali-Krishna K, van der Most RG, §Ahmed R (2003) Viral Persistence Alters CD8 T-cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment, J Virol 77(8):4911-4927.

26. Seiffert M, Custodio JM, Wolf I, Harkey M, Liu Y, Blattman JN, Greenberg PD, §Rohrscneider LR (2003) Gab3-Deficient Mice Exhibit Normal Development and Hematopoiesis and are Immunocompetent, Mol Cell Biol 23(7):2415-2424.

27. Slifka MK, Blattman JN, Sourdive DJD, Liu F, Huffman DL, Wolfe T, Hughes A, Oldstone MBA, Ahmed R, §von Herrath MG (2003) Preferential Escape of Subdominant CD8+ T cells during Negative Selection Results in an Altered Antiviral T cell Hierarchy, J Immunol 170(3):1231-1239.

28. Blattman JN, Antia R, Sourdive DJD, Murali-Krishna K, Wang X, Kaech SM, Altman JD, §Ahmed R (2002) Estimating the Precursor Frequency of Naïve Antigen-Specific CD8+ T Cells, Brief Definitive Report, J Exp Med 195(5):657-664.

29. Blattman JN, Sourdive DJD, Murali-Krishna K, Ahmed R, §Altman JD (2000) Evolution of the T Cell Repertoire during Primary, Memory, and Recall Responses to Viral Infection, J Immunol 165(11):6081-6090.

30. Zajac AJ, Blattman JN, Murali-Krishna K, Sourdive DJD, Suresh M, Altman JD, §Ahmed R (1998) Viral Immune Evasion due to Persistence of Activated T Cells Without Effector Function, J Exp Med 188(12):2205-2213.


Invited Review Articles/Book Chapters 31. Lussier DM✪, Appel N✪, §Blattman JN (2016) Immune Checkpoint Blockade in Osteosarcoma in

“Osteosarcoma – Biology, Behavior and Mechanisms”, K. Honoki ed, InTech Open Publishers, ISBN 978-953-51-4915-6 (in press).

32. Lettieri C, Lussier DM✪, Appel N✪, Labban N✪, Blattman JN, §Hingorani P (2016) Progress and Opportunities for Immune Therapeutics in Osteosarcoma, Immunotherapy 8(10):1233-1244.

33. Schoettle LN✪, Poindexter ME✪, §Blattman JN (2015) T Cell Receptors, Encyclopedia of Life Sciences, John Wiley & Sons.

34. McAfee MS✪, §Blattman JN (2012) Combating Chronic T Cell Exhaustion, Immunotherapy 4(6):567-560. 35. Blattman JN, §Greenberg PD (2006) PD-1 Blockade: Rescue from a Near-Death Experience, Nat Immunol

7(3):227-228. 36. Blattman JN, §Greenberg PD (2004) Cancer Immunotherapy: A Treatment for the Masses, Science

305(5681):200-205. 37. Ho WY, Blattman JN, Dossett M, Yee C, §Greenberg PD (2003) Adoptive Immunotherapy: Engineering T

Cell Responses as Biologic Weapons for Tumor Mass Destruction, Cancer Cell 3(5):431-437. 38. Blattman JN, Cheng LE, §Greenberg PD (2002) CD8+ T cell responses: It’s all downhill after their prime…,

Nat Immunol 3(7):601-602. 39. Blattman JN~, Zajac AJ~, Murali-Krishna K, Sourdive DJD, Suresh M, Altman JD, §Ahmed R (1999) T Cell

Anergy During Chronic Viral Infection in “Factors in the Emergence and Control of Rodent-borne Diseases (Hantaviral and Arenal Diseases)”, J.F. Saluzzo and B. Dodet, ed., Elsevier, Paris, pp. 243-253.

40. Zajac AJ, Murali-Krishna K, Blattman JN, §Ahmed R (1998) Therapeutic Vaccination Against Chronic Viral Infection: The Importance of Cooperation Between CD4+ and CD8+ T Cells, Curr Opin Immunol 10(4):444-449.

Conference Proceedings 1. Franco LS✪, Holechek SA✪, Caplan M, §Blattman JN (2016) Sequence-Specific Detection of Different

Strains of LCMV Viruses in a Single Sample using Tentacle Probes, J Immunol 196 (1 Supplement), 69.3. 2. Lussier DM✪, Johnson JL✪, Hingorani P, §Blattman JN (2015) Combining CTLA4 and PD-L1 Blockade Leads

to Complete Eradication of Metastatic Osteosarcoma, Cancer Immunologoy Research 3(Suppl 10):A07. 3. Johnson JL✪, Woolf EC, Lussier DM✪, Brooks KS, Blattman JN, Scheck AC (2015) Ketogenic Diet

Enhances Immunity to Glioblastoma, Cancer Immunologoy Research 3(Suppl 10):B73. 4. Woolf EC, Johnson JL✪, Lussier DM✪, Brooks KS, Blattman JN, Scheck AC (2015) The Ketogenic Diet

Enhances Immunity in a Mouse Model of Malignant Glioma, Cancer Res 75 (Suppl 15):1344. 5. Contreras C, McKay J, Blattman JN, §Holechek SA✪ (2015) Modeling the Lymphocytic Choriomeningitis

Virus: Insights Into Understanding Its Epidemiology in the Wild, Bull Amer Phys Soc 60(2):P1.00121. 6. Schoettle LM✪, Wei X, Garcia-Neuer M✪, Zarnitsyna V, Antia R, Yan H, §Blattman JN (2014) DNA Origami:

Single Cell Analysis of T Cell Receptors without Single Cell Sorting, J Immunol 192:193.7 7. Chowell D, Krishna S, §Blattman JN, Anderson K (2014) Hydrophobicity is a Hallmark of Immunogenic MHC

Class I T Cell Epitopes, J Immunol 192:43.12 8. Lussier DM✪, Nieves LM✪, McAfee MS✪, Hyunh TP, Holecheck SA✪, Hingorani P, §Blattman JN (2013)

Enhancement of T Cell Immunity to Osteosarcoma through Modulation of PD-1/PD-L1 Interactions, J ImmunoTherapy of Cancer 1(Suppl 1):P162.

9. Schoettle LM✪, Wei X, Yan H, §Blattman JN (2013) A Direct Approach for Measuring Total TCRαβ Diversity, J Immunol 190:135:3

10. McAfee MS✪, Johnson P, Antia R, §Blattman JN (2013) A Quantitative Explanation of Vaccination for Disease, J Immunol 190:123:21

11. Holechek SA✪, Nieves L✪, McAfee MS✪, Guzman V✪, Bruce C✪, §Blattman JN (2013) Using the Lymphocytic Choriomeningitis Virus Mouse Model of Infection to Link Specific Immune Responses with Epidemiological Outcomes, J Immunol 190:182:11

12. Stromnes IM★, Fowler CC★, Casamina CC, Geogopolos CM, McAfee MS, Scmitt TM, Tan X, Kim T-D. Choi I, Blattman JN, §Greenberg PD (2012) Abrogation of SHP-1 in Tumor-Specific T Cells Improves Efficacy of Adoptive Immunotherapy by Enhancing the Effector Function and Accumulation of Short-Lived Effector T Cells In Vivo, J Immunol 189:4.1812.


13. §Greenberg PD, Ragnarrson G, Schmitt TM, Ochsenreither S, Teague RM, Chou C★, Fowler CC★, Schietinger A★, Stromnes IM★, Blattman JN, Aggen DH, Kranz DM, Kuball J (2011) TCR-Directed Immunotherapy of Leukemia, Ann Hematol 90(S1):S50-51.

14. Larrimore K★, Blattman JN, §Greenberg PD (2010) Neutralizing Antibody and Germline Precursor Knock-In Mice to Facilitate HIV-1 Vaccine Development, AIDS Res Hum Retroviruses 26(10):A58.

15. Scherer EM★, Vogt J, Spies G, Greenberg PD, §Blattman JN (2010) A Recombinant Yellow Fever Virus Vaccine Expressing an SIV Gag Protein Induces B- and T-Cell Immunity in Murine Model, AIDS Res Hum Retroviruses 26(10):A38.

16. Tan X★, Blattman JN, Sande JL★, Pufnock J★, Bergthaler A, §Greenberg PD (2010) Retinoic Acid as an Adjuvant During Systemic Vaccination Enhances Protection from Mucosal Viral Challenge, AIDS Res Hum Retroviruses 26(10):A133.

17. §Greenberg PD, Ragnarrson G, Schmitt T, Chou C★, Fowler CC★, Schietinger A★, Stromnes IM★, Blattman JN (2010) Overcoming Obstacles to Effective T Cell Therapy of Malignant Disease, Int Immunol 22:4-5 Suppl1 Pt1.

18. Stromnes IM★, Fowler CC★, Blattman JN, Tan X★, §Greenberg PD (2010) Abrogation of SHP-1 in Tumor-Specific Effector T Cells During Adoptive Immunotherapy of Disseminated Leukemia, J Immunol 184:131.15.

19. Tan X★, Blattman JN, Sande J★, §Greenberg PD (2009) All-Trans Retinoic Acid as an Adjuvant can Imprint Mucosal Homing Properties to Vaccine-Induced T Cells, AIDS Res and Hum Retroviruses 26(10):A133.

20. §Blattman JN, Tan X★, Sande JL★, Pufnock J★, Greenberg PD (2009) All-Trans Retinoic Acid During Vaccination Increases Antigen-Specific CD8 T Cell Homing to Mucosal Sites and Improves Recall Responses to Vaginal Challenge, Retrovirology 6(Suppl 3):P10.

21. Schietinger A★, Fowler CC★, Teague RM, Tan X★, Blattman JN, §Greenberg PD (2009) Homeostatic Proliferation Transiently Rescues Tolerant CD8+ T Cells, J Immunol 182:51.57.

22. Stromnes IM★, Tan X★, §§Blattman JN, §§Greenberg PD (2009) Cbl-b-Deficiency in Tumor Reactive CD8+ T Cells Improves Efficacy and Bypasses the Requirement for IL-2 Administration During Adoptive Therapy of Progressive Leukemia, J Immunol 182:40.38.

23. Tan X★, Blattman JN, §Greenberg PD (2009) Retinoic Acid as an Adjuvant to Imprint Mucosal Homing Properties to Vaccine-Induced T Cells, J Immunol 182:39.32.

24. Fowler CC★, Pao L, Schietinger A★, Tan X★, §§Blattman JN, §§Greenberg PD (2009) SHP-1 Regulation of In Vivo CD8 T Cell Responses, J Immunol 182:35.43.

25. §Greenberg PD, Teague RM, Wolfl M, Ho WY, Ragnarsson G, Kuball J, Wang X, Fowler CC★, Puffnock J★, Tan X, Chapuis A, Casper C, Corey L, Blattman JN (2007) Generating Therapeutic/Protective T-Cell Responses to Tumors and HIV: “More is Better, But Will It Be Enough?” Cancer Immunity 8 (Suppl 1:7).

26. §Greenberg PD, Ho WY, Wolfl M, Teague RM, Morimoto J, Dossett M, Kuball J, Yang Y, Fowler CC★, Blattman JN (2005) Overcoming Obstacles to the Generation of T Cells for Tumor Therapy, Cancer Immunity 6 (Suppl 1:13).

27. Wherry EJ, Barber DL, Kaech SM, Blattman JN, §Ahmed R (2005) Antigen-Independent Memory CD8 T Cells do Not Develop During Chronic Viral Infection, FASEB Journal 19(S4):A394,

28. §Greenberg PD, Ho WY, Wolfl M, Teague RM, Morimoto J, Dossett M, Blattman JN (2004) Isolating Tumor-Reactive T cells and Making Them Work in Tumor Therapy, Cancer Immunity 5 (Suppl 1:25).

29. §Greenberg PD, Blattman JN, Cheng LC, Dossett M, Fowler CC★, Hamel Y, Ho WY, Kranz DM, Ochsenbein A, Ohlen C, Topp M, Yee C (2003) Engineered T Cells as Reagents to Understand and Overcome the Limitations of Naturally- or Vaccine-Induced T-Cell Responses, Cancer Immunity 3 (Suppl 2:11).

Textbooks and Instructional Materials 1. §Blattman JN, McAfee MS✪, Schoettle LN✪. 1st ed. (2016) The Immune System: An Experimental Approach,

Cognella, Inc. Publishers, San Diego CA. 2. §Blattman JN, Blattman NN, Lussier DM✪. (2014) www.interactiveImmunology.com.

* Interactive, simulated patient case-study software used in MIC 425: Advanced Immunology taught by Dr. JN Blattman. Accessible via InteractiveImmunology.com (password protected, available upon request), these case studies are currently being implemented in undergraduate, graduate, and medical student Immunology classes at: Arizona State University, Vanderbilt University, Emory University, University of Pennsylvania, University of Nevada-Las Vegas, University of Arizona, and University of Minnesota.


Mentoring Post-doctoral Fellow Research Advisor Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ Susan Holechek (PhD Molecular and Cellular Biology, Arizona State University, 2012) 2012-2016

Instructor, Arizona State University (2016-present )

PhD Graduate Student Research Advisor School of Life Sciences, Arizona State University, Tempe, AZ

Ammar Tanveer (Molecular and Cellular Biology) 2016-current Nicole Appel (Molecular and Cellular Biology) 2015-current Joshua Carmen (Microbiology, LTHET Fellow, US Army Medical Research Program) 2015-current Kavita Manhas (Molecular and Cellular Biology) 2015-current Rebecca (McCall) Cook (Biological Design, ARCS Scholar, Co-mentor w/ Dr. R. Sirianni, BNI) 2015-current Peaches Ulrich (Molecular and Cellular Biology, IMSD Fellow, Co-mentor w/ Dr. K. Anderson, ASU) 2015-current Lina Franco (PhD Chemistry and Biochemistry 2016) 2013-2016 Post-doctoral fellow, Arizona State University, Tempe AZ (Dr. Grant McFadden, 2016-present) Louis Schoettle (Microbiology, Roche/ARCS Scholar) 2012-current Danielle Lussier (PhD Molecular and Cellular Biology 2015) 2012-2015 Post-doctoral fellow, Washington University in St Louis, St Louis MO (Dr. Robert Schreiber, 2015-present) Megan McAfee (PhD Molecular and Cellular Biology 2015) 2011-2015

Post-doctoral fellow, Fred Hutchinson Cancer Research Center, Seattle WA (Dr. Aude Chapuis, 2015-present)

MS Graduate Student Research Advisor School of Life Sciences, Arizona State University, Tempe, AZ

Morgan Poindexter (4+1 Biology) 2015-2016

PhD Program in Immunology, University of California, Davis (2016-present)

Post-Baccalaureate Research Supervisor School of Life Sciences, Arizona State University, Tempe, AZ

Evelyn Luna (BS Biology, Arizona State University 2016, PREP Scholar) 2016-current Brittany Ulloa (BS Chemistry, Cal. State University 2013, PREP Scholar, Co-Mentor w/ Dr. K. Anderson, ASU) 2015-current Brianna Boyles (BS Psychology, Arizona State University 2013) 2015-2016

PA Program, Northern Arizona University (2016-present) Maria Josefina Cruz Perez (COMEX Becas Fulbright-Garcia Robles Scholar, Instituto Tecnologico 2015

Superior de Misantla) Lauren O’Neill (BS Biochemistry, University of Arizona 2013, PREP Scholar) 2013-2015

PhD Program in Immunobiology, King’s College, London (2015-present) John Johnson (BS Biochemistry, Arizona State University 2013) 2013-2015

PhD Program in Immunology, University of Pennsylvania (2015-present)

Undergraduate Research Supervisor School of Life Sciences, Arizona State University, Tempe, AZ

Zachary Contursi (Microbiology, Barrett Honors College) 2016-current Sierra Bichler (Biochemistry, Barrett Honors College) 2016-current Han Kim (Biology (Neurobiology, Physiology, & Behavior), Barrett Honors College) 2016-current Abigail Reed (Biological Sciences, Barrett Honors College) 2015-current Britney Tillis (Biological Sciences, Barrett Honors College) 2015-current Jonathan Burbidge (Biological Sciences, Barrett Honors College) 2015-2016 Nicole Labban (Biological Sciences, Barrett Honors College) 2015-2016 DO Program, A.T. Still University (accepted for 2016 admission – deferred to 2017)


Kristin Morrow (Microbiology, Barrett Honors College, SOLUR Fellow) 2015-2016

PhD Program in Immunology & Molecular Pathogenesis, Emory University (2016-present) Kelley O’Brien (BS Biological Sciences 2015, Barrett Honors College, Co-Mentor w/ Dr L. Inge, SJH) 2014-2015

Research Technician, Norton Thoracic Institute, St. Joseph’s Hospital, Phoenix AZ Kavita Manhas (BS Microbiology 2015) 2014-2015

PhD Program in Molecular and Cellular Biology, Arizona State University (2015-present) Anne Richards (BS Chemistry & Biochemistry 2015, Barrett Honors College, Co-Mentor: Dr L. Clark-Steffen) 2014-2015 Morgan Poindexter (BS Microbiology 2015, Barrett Honors College) 2014-2015 MS Program in Biology, Arizona State University (2015-2016) Cody Frear (BS Biology & BS Anthropology 2015, Barrett Honors College, Flinn Scholar) 2014-2015

MD Program, Uniformed Services University of the Health Sciences (2016-present) Jordan Jarvis (BS Microbiology 2014, Barrett Honors College) 2013-2014

Business Improvement Specialist, ESI Ergonomic Solutions Charles Miller (BS Biological Sciences, Barrett Honors College, SOLUR Fellow, Flinn Scholar) 2012-2016 MSBA Program, Arizona State University (2017-present) Vanessa Guzman (BS Microbiology 2014, IMSD Scholar) 2012-2014 PA Program, Western University, Pomona CA (2014-2016) Lizbeth Nieves (BS Molecular Biosciences and Biotechnology 2014, SOLUR Fellow) 2012-2014 Laboratory Technician, Dr. Xuan Wang, Arizona State University Courtney Bruce (BS Biological Sciences & BS Anthropology 2013, Barrett Honors College) 2012-2013 MPH Epidemiology, Columbia University Mailman School of Public Health (2015) Data Scientist, IBM Analytics (2015-present) Marlene Garcia-Neuer (BS Microbiology, 2014, Barrett Honors College) 2011-2014 MS Clinical Investigation, Boston University (2015) Erin Creevy (BS Microbiology 2013) 2011-2013 Clinical Coordinator, AZ Heart Rhythm Center, Phoenix AZ Kathleen Griffith (BS Biochemistry 2013, University of Indiana) 2011-2012 MEd Program in Secondary Education: Physical Sciences, Xavier University Lynda Idouraine (BS Molecular Biosciences and Biotechnology 2012) 2011-2012 PhD Program in Pharmacy, University of Arizona

High School Research Supervisor School of Life Sciences, Arizona State University, Tempe, AZ

Mason Kahn (Mesquite High School, Gilbert AZ) 2015-2016 Amanda Beltran (Mountain View High School, Mesa AZ) 2015

Abigail Reed (Hamilton High School, Chandler AZ) 2013-2015 Biological Sciences, Arizona State University

Emily Galloway (Hamilton High School, Chandler AZ) 2013-2015 Molecular & Cellular Biology Program, University of Arizona

Alisha Joshi (Hamilton High School, Chandler AZ) 2013-2015 3-4 Medical Program, State University of New York, Geneseo NY

PhD Thesis Committee Member School of Life Sciences, Arizona State University, Tempe, AZ

Ammar Tanveer (Committee Chair, Molecular and Cellular Biology) 2016-current Joshua Carmen (Committee Chair, Microbiology) 2015-current Kavita Manhas (Committee Chair, Molecular and Cellular Biology) 2015-current Rebecca McCall (Committee Co-Chair, Biological Design) 2015-current George Brusch IV (Biology) 2015-current Peaches Ulrich (Committee Co-Chair, Molecular and Cellular Biology) 2015-current Emily Julik (Molecular and Cellular Biology) 2015-2016


Diego Chowell-Puente (Applied Mathematics) 2015-2016 Sambhavi Sambramanian (Neuroscience) 2014-current Jordan Yaron (PhD Biological Design 2015) 2014-2015 Lina Franco (Committee Co-Chair, Chemistry and Biochemistry) 2013-2016 Louis Schoettle (Committee Chair, Microbiology) 2012-current Lydia Meador (Biological Design) 2012-2016 Heather Harrington (Molecular and Cellular Biology) 2012-2016 Danielle Lussier (Committee Chair, PhD Molecular and Cellular Biology 2015) 2012-2015 Brian Johnson (Biological Design) 2011-current Megan S. McAfee (Committee Chair, PhD Molecular and Cellular Biology 2015) 2011-2015 Xiao Wang (MS Biological Design 2013) 2011-2013 Arpan Deb (Molecular and Cellular Biology) 2011-2012

MS Thesis Committee Member School of Life Sciences, Arizona State University, Tempe, AZ

Zuena Mushtaq (Microbiology) 2016 Morgan Poindexter (Committee Chair, Biology) 2015-2016 Jeffrey Liao (Microbiology) 2014-2015 Jacqueline Friel (MS Biology 2015) 2013-2015

Honors Undergraduate Thesis Committee Member School of Life Sciences, Arizona State University, Tempe, AZ

Zachary Elwell (Committee Co-Chair Biological Sciences) 2016-current Clayton Foster (Biological Sciences) 2016-current Hamed Alattar (Biological Sciences) 2016-current Tala Mujahed (Biological Sciences) 2016-current Harneet Grewal (Psychology) 2016 Yi Jia (Valerie) Loo (Biochemistry: Medicinal Emphasis) 2016 Alex Roesler (Biochemistry: Medicinal Emphasis) 2016 Abigail Reed (Committee Chair, Biological Sciences) 2015-current Brittney Tillis (Committee Chair, Biology) 2015-current Nicole Labban (Committee Chair, Biological Sciences) 2015-2016 Kristen Morrow (Committee Chair, Microbiology) 2015-2016 Morgan Poindexter (Committee Chair, Biology) 2014-2015 Anne Richards (Committee Co-Chair, Biochemistry, Co-Mentor w/ Dr. L Clark-Steffen, PCH) 2014-2015 Kelley O’Brien (Committee Co-Chair, Biological Sciences, Co-Mentor w/ Dr. L. Inge, SJH) 2014-2015 Rebekah Dickey (Microbiology) 2014-2015 Cody Frear (Committee Chair, Biology) 2013-2015 Jordan Jarvis (Committee Chair, Microbiology) 2013-2014 Charles Miller (Committee Chair, Biological Sciences) 2012-2016 Marlene Garcia-Neuer (Committee Chair, Microbiology) 2012-2014 Courtney Bruce (Committee Chair, Biological Sciences) 2012-2013

PhD Comprehensive Exam Committee Member School of Life Sciences, Arizona State University, Tempe, AZ

Valerie Harris (Biological Design) 2016 Melissa Crawford (Biological Design) 2016 George Brusch IV (Biology) 2016 Mateusz Szczerba (Biological Design) 2015


Lydia Meador (Biological Design) 2013 Brian Johnson (Biological Design) 2012 Arpan Deb (Molecular and Cellular Biology) 2012

Creative and Novel Ideas in HIV Research (CNIHR) Grant Mentor Center for AIDS Research (CFAR) University of Washington, Seattle WA Dr. Owen Proudfoot (post-doctoral fellow in the laboratory of Dr. G. Pietersz, Burnet Institute, 2010-2011

Prahran, Victoria, Australia) Post-Doctoral Research Advisor (with Dr. Philip Greenberg) Greenberg/Blattman Lab, Department of Immunology, School of Medicine University of Washington, Seattle, WA

Kevin Larrimore (Immunology Laboratory Director, BioMarin Pharmaceuticals, San Francisco CA) 2009-2011 Erin Scherer (Post-doctoral fellow, Fred Hutchinson Cancer Research Center, Seattle WA) 2009-2011 Jeff Pufnock (Scientist II, Clinical Immunology, Dendreon, Seattle WA) 2009-2011 Andrea Schietinger (Assistant Professor, Memorial Sloan Kettering Cancer Center, New York NY) 2008-2011 Ingunn Stromnes (Research Associate, Fred Hutchinson Cancer Research Center, Seattle WA) 2007-2011 Xuefang Tan (Assistant Professor, Centre for Infection and Immunity, Guangzhou 2006-2011

Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, China) Graduate Student Advisor (with Dr. Philip Greenberg) Greenberg/Blattman Lab, Department of Immunology, School of Medicine University of Washington, Seattle, WA

Cassie Chou (Ph.D. in Immunology, 2012, Pediatric Physician, Seattle Children’s Hospital, Seattle WA) 2009-2011 Carla Fowler (Ph.D. in Immunology, 2011, Managing Director, THAXA Inc., Seattle WA) 2006-2011

Undergraduate Research Supervisor (with Dr. Philip Greenberg) Greenberg/Blattman Lab, Department of Immunology, School of Medicine University of Washington, Seattle, WA

Joshua Guilland (MD program, University of Washington, Seattle, WA) 2010-2011 Hae-Soo Park (Research Scientist, Immunology, University of Washington, Seattle, WA) 2008-2011 Jamie L. Sande (PhD, Clinical Laboratory Science, Oregon Health & Science University) 2006-2010

High-School Summer Research Supervisor (with Dr. Philip Greenberg) Greenberg/Blattman Lab, Department of Immunology, School of Medicine University of Washington, Seattle, WA

Lilian Ho (BS, MD University of Washington, Seattle, WA currently: MD Pediatrics Seattle Children’s Hospital) 2002

Teaching Courses Developed / Primary Instructor MIC/BIO 420: Immunology: Molecular and Cellular Foundations (3 credits) 2016 Fall (co-listed as MIC/MCB 598: Immunology: Molecular and Cellular Foundations) 2015 Fall This course is designed to introduce undergraduate students to the fundamental principles of immunology including self/non- 2014 Fall self discrimination, innate and adaptive immune cell subsets, responses to microbial infection and cancers, and vaccination 2013 Fall resulting in immune memory. Immunologic principles are reinforced through active learning exercises and problem solving.

MIC 421: Experimental Immunology (Lab) (2 credits) 2017 Spring This course is designed to teach the fundamentals of immunology to undergraduate students using current immunological 2016 Spring methods as well as providing hands-on experience in experimental design and performing immune system based scientific 2015 Spring inquiries. Beginning in Spring 2017, this course will be taught in a CURE (classroom undergraduate research experience 2014 Spring format with analysis of previously immunologically undefined strains of mice and peer-reviewed publication of results. This 2013 Spring course utilizes the text by Blattman, Schoettle, & McAfee – Immunology: An Experimental Approach


MIC 425: Advanced Immunology (3 credits) (co-listed as MIC 598: Advanced Immunology) 2017 Spring This course is designed to give immunology students an advanced in-depth understanding of human diseases that result 2016 Spring from dysfunction of the immune system during autoimmunity or acquired infection. Classes are divided between lecture on 2015 Spring advanced immunologic topics (with discussion of recent advances) and small group problem solving in the form of simulated 2014 Spring patient case presentation, molecular diagnosis, and therapy design. Students utilize a discovery platform website 2013 Spring (www.interactiveImmunology.com) developed by Dr. Blattman, which details clinical presentation, immunological features, 2012 Spring diagnostic techniques, and treatment for selected immunodeficiencies.

MCB 501: Foundations of Microbiology (3 credits) 2016 Fall Graduate level overview of the field of microbiology including: bacterial genetics and physiology, virology, and host/pathogen 2015 Fall interactions through lectures, reading, presentations and discussion of papers in in the field of microbiology and immunology. Students are expected to read all papers and to participate in class discussions. Students will also be responsible for presenting papers during the semester. MIC 591: Immunology & Molecular Pathogenesis (3 credits) 2017 Spring Presentations and discussion of graduate studies in immune responses to infection and tumors.

MCB 701: Molecular and Cellular Biology Colloquium (1 credit) 2015 Spring Seminar-based course bringing internal and external student and post-graduate level speakers for presentation of 2014 Spring/Fall molecular and cellular biology topics. 2013 Spring/Fall Guest Lectures BIO 189: Life Sciences Career Paths (Recitation) (5 lectures) 2016 Fall Topic: Vaccination, Infection, Immunology and Disease 2015 Fall Freshmen School of Life Sciences students participate in an overview of the opportunities for and complexities of biological 2013 Fall research including infection, immune responses, disease states, and vaccination to prevent disease. 2012 Fall

BIO 394: Evolution of Cancer (1 lecture) 2016 Fall Topic: Vaccines Lecture on vaccine design, considerations for use, and vaccination strategies. HON 498/BDE 598: Introduction to Biological Design (1 lecture) 2016 Fall Topic: Mathematical Models of Infection, Immunity, & Disease Lecture on modeling immunopathology during virus infection. MIC 485/598: General Virology (2 lectures) 2016 Fall Topic: Virus / Host Interactions 2015 Fall Lectures on host/pathogen interactions, immune responses to viral infection, immune evasion strategies 2014 Fall 2013 Fall 2012 Fall MIC 485/598: Vaccines (1 lecture) 2013 Spring Topic: Vaccination Discussion of student presentations on vaccines and vaccination strategies.

MIC 494/598: Novel Models for Infectious Disease Research (1-2 lectures) 2017 Spring Topic: Humanized Mouse Models 2016 Spring Lecture on the development, utility, and proper use of different humanized mouse infectious disease models. 2014 Fall 2013 Fall Research / Papers Courses BCH 392: Introduction to Research Techniques Instrumental methods and philosophy of research by actual participation in biochemical research projects.

Student: Anne Cambrelin Project: Assessment of inhibitory protein suppression of anti-tumor T cell responses. 2013 Spring

MIC 401: Research Paper Supervised discussion of current topics in microbiology/immunology.

Student: Sarah Haller Topic: TBD. 2017 Spring


Student: Devin Shumway Topic: TBD. 2017 Spring Student: Andrea Miller Topic: TBD. 2017 Spring Student: Lara McClure Topic: TBD. 2017 Spring Student: Bradley Tridle Topic: Brown spider venom immunotherapy. 2016 Fall Student: Sean Hanci Topic: Zika virus vaccines and antibody enhancement of Dengue infection. 2016 Fall Student: Eugene Chung Topic: Combinatorial immunotherapy and radiation for glioma. 2016 Spring Student: Charles Miller Topic: Immunopathology during vaccination for viral infection. 2016 Spring Student: Jonathan Burbige Topic: Overcoming macrophage suppression of immunity to solid tumors. 2016 Spring Student: Daniel Overman Topic: Development of vaccines for Zika viral infection. 2016 Spring Student: Jessica Keeler Topic: Fecal transplant for food allergies. 2016 Spring Student: Kristen Morrow Topic: Vertical transmission in selection of less pathogenic viruses. 2016 Spring Student: Haley Owen Topic: Understanding tumor heterogeneity. 2016 Spring Student: Jared Bailey Topic: Point-of-care microarray platforms for rapid diagnosis of infectious diseases. 2015 Fall Student: Steven Ohnmacht Topic: Scabies Th1 vaccine. 2015 Fall Student: April Small Topic: Development of new therapeutic antibodies for immune checkpoint proteins. 2015 Fall Student: Daniel Nieto Topic: Regulatory CD4 T cell therapy of autoimmunity. 2015 Summer Student: Rebecca Richardson Topic: Hematopoiesis and immunity in low gravity. 2015 Spring Student: Sean McMullen Topic: Obstacles to phage therapy of infection. 2014 Fall Student: Kristina Bowman Topic: Fecal transplant therapy for autism spectrum disorder. 2014 Fall Student: Adam Lane Topic: DNA vaccination for C. Difficile. 2014 Fall Student: Paula Raney Topic: Preventative strategies for Nosocomial Infections: Legionella pneumonphila 2014 Fall Student: Luce Kassi Topic: The race for an Ebola vaccine. 2014 Fall Student: Vanessa Guzman Topic: Linking immunology and epidemiology for virus infection. 2014 Fall Student: Dee Sagawe Topic: TGE-virus vaccination of Pacific Salmon. 2014 Spring Student: Jordan Jarvis Topic: Role of TNF-receptors in pathogenesis during viral infection. 2014 Spring Student: Anthony Jones Topic: Mycobacterium turberculosis immunity. 2014 Spring Student: Jessica (Haley) Hann Topic: Respiratory syncitial virus vaccine enhancement of pathology. 2014 Spring Student: Marlene Garcia-Neuer Topic: T cell receptor diversity in genetically identical individuals. 2014 Spring Student: Saleh Gani Topic: NOD2 gene therapy for Crohn’s disease. 2013 Fall Student: Amber Webster Topic: Vaccine enhancement of regulatory T cells to treat autoimmunity. 2013 Spring Student: Veronica Russian Topic: Bacteriophage vaccine vectors for MRSA infection. 2013 Spring Student: Erin Creevy Topic: Vaccination for disease. 2013 Spring Student: San Tchao Topic: Combination therapy with oncolytic viruses. 2012 Fall Student: Zalak Jayswal Topic: Vaccination for disease. 2012 Spring

BIO/MBB/MIC 492: Honors Directed Study (variable credit) Supervised honors research in microbiology.

Student: Zachary Elwell Project: Immunotherapy of Chronic Rhinosinusitis. 2016 Fall Student: Han Kim Project: Chemotherapy and Immunotherapy of Metastatic Osteosarcoma. 2016 Fall Student: Sierra Bichler Project: Immunotherapy of Glioma. 2016 Fall Student: Nicole Labban Project: Chemotherapy and Immunotherapy of Metastatic Osteosarcoma. 2015 Fall Student: Kristen Morrow Project: Generation of and viral evolution in LCMV congenital carrier mice. 2015 Fall Student: Charles Miller Project: Linking immunologic parameters with epidemiologic outcomes during virus exposure. 2015 Fall Student: Morgan Poindexter Project: Development of DNA origami nanostructures for capture and analysis of BCR. 2014 Fall Student: Marlene Garcia-Neuer Project: Analysis TCRβ marginal frequencies in polyclonal T cell populations. 2012 Fall

BIO/MBB 493: Honors Thesis (variable credit) Supervised honors thesis research in biology.

Student: Zachary Elwell Project: Immunotherapy of Chronic Rhinosinusitis. 2017 Spring Student: Sierra Bichler Project: Chlorotoxin-CD3 Immunotherapy of Glioblastoma. 2017 Spring Student: Han Kim Project: Chemotherapy and Immunotherapy of Metastatic Osteosarcoma. 2017 Spring Student: Kristen Morrow Project: Generation of and viral evolution in LCMV congenital carrier mice. 2016 Spring Student: Cody Frear Project: Epidemiological models of virus infection and transmission 2015 Spring Student: Morgan Poindexter Project: Molecular linking of BCR from single cells without single cell sorting 2015 Spring Student: Courtney Bruce Project: Epidemiological models of virus infection and transmission 2013 Spring

MIC/MBB/BIO 495: Undergraduate Research (variable credit)


Supervised research in biology/microbiology/molecular biosciences and biotechnology. Student: Nicole Labban Project: Chemotherapy and Immunotherapy of Metastatic Osteosarcoma. 2016 Spring Student: Morgan Poindexter Project: Development of DNA origami nanostructures for capture and analysis of BCR. 2014-15 Fall/Spring Student: Vanessa Guzman Project: Comparison of virus transmission from congenitally- and adult-infected mice. 2014 Fall Student: Charles Miller Project: Analysis of cross-presentation of T cell epitopes in GILT-/- mice. 2013 Spring Student: Marlene Garcia-Neuer Project: Marginal frequency of TCRβ in polyclonal T cell populations. 2013 Spring/Fall Student: Lizbeth Nieves Project: Linking immunological and epidemiological measures of vaccine efficacy 2012 Summer/Fall Student: Lynda Idouraine Project: Testing anti-mouse antibodies on deer mouse (P. maniculatis) lymphocytes 2012 Spring/Summ Student: Erin Creevy Project: Testing parameters of quantitative models of immunopathology during virus infection. 2012 Spring

MIC 584: History of Immunology Teaching Internship (3 credits) Student: Jennifer Craer Topic: Social, historical, ethical and scientific context of landmark papers in immunology 2014 Fall

BIO 790: Reading and Conference (variable credit) Student: Hua “Tiger” Dan (1cr) Topic: Tumor immune surveillance, editing, and evasion 2012 Spring

BDE 792: Graduate Research (variable credit) 2017 Spring Student: Rebecca Cook (1cr) Topic: Immunotherapy of Glioma 2016 Summer/Fall

Service International Programme Committee Member, 1st International Workshop on Artificial 2014 Immune Systems: Systems 2015, Programme Committee for Systems & Synthetic Immunology, Computational Immunology & Immune-Inspired Engineering, Taormina, Italy Co-chair, Technological Innovations in Immunology – Session 1 2013 The American Association of Immunologists Annual Meeting: IMMUNOLOGY 2013, Honolulu, HI. Programme Committee Member, 11th International Conference on Artificial 2012 Immune Systems 2012, Programme Committee for Computational Immunology, Immunoinformatics, Theoretical Immunology, & Systems Immunology, Taormina, Italy

Editorial Board Advances in Genetic Engineering & Biotechnology 2014-current International Journal of Immunology and Immunotherapy 2014-current Review Editor Frontiers in Mucosal Immunity 2010-current Ad-hoc Reviewer Science, Nature Immunology, Frontiers in Immunology, Journal of Proteome Research, PLos One, PLoS Pathogens, Journal of Immunology, Journal of Experimental Medicine, Blood, Journal of Acquired Immune Deficiency Syndromes, Frontiers in Microbiology, Genome Medicine, Journal of Immunotherapy, FEBS Open Bio, Cancer Immunology Research Grant Reviewer National Science Centre, Poland (Funding Scheme SONATA, panel NZ6) 2016 Regional President, American Society for Microbiology, AZ / Southern NV Branch 2016-current Immunology Faculty Search Committee (Univ of Arizona-College of Medicine, Phoenix, AZ) 2016-current President-Elect, American Society for Microbiology, AZ / Southern NV Branch 2015-2016 Organizer, American Society for Microbiology, 55th Annual Branch Meeting, Tempe, AZ 2015-2016 Arizona State University Science Olympiad, Event Supervisor 2017 Center for Immunotherapy, Vaccines and Virotherapy (CIVV), Internal Advisory Board 2016-current South and Central American Research Consortium for Emerging Infectious Diseases, Lead 2016-current


Immunology Graduate Student Association, Faculty Advisor 2016-current Biological Design Graduate Program, Admissions Committee 2015-current Student-Faculty Policy Committee 2014-2015 Rodent Breeding Policy Working Group 2013 Mentoring to Advance Postdocs and Students Program, panelist 2013 University Faculty Senate 2012-2015 College of Liberal Arts and Sciences Senate 2012-2015 Career Service Employer Panel for Science Careers, panelist 2012 School of Life Sciences Virology/Innate Immunity Faculty Search Committee, Co-Chair 2016-current Director, Microbiology Graduate Program 2016-current Bio-Bridge Ignite Camp, Faculty Mentor 2015 Co-Director, Microbiology Graduate Program 2014-2016 Macrosystems Biology Faculty Search Committee 2014-2015 School of Life Sciences Director Search Committee 2014-2015 Executive Committee, Molecular and Cellular Biology Graduate Program 2013-2015 Previous Service (University of Washington) Institutional Biosafety Committee, Fred Hutchinson Cancer Research Center, Seattle, WA 2008-2011 Institutional Animal Care & Use Committee, University of Washington, Seattle, WA 2009-2011 Professional Memberships and Activities Arizona-Nevada Academy of Science 2016-current American Society for Microbiology (ASM, AZ/Southern NV Branch & National Member) 2012-current American Association for the Advancement of Science (AAAS) 2002-current American Association of Immunologists (AAI) 1998-current Federation of American Societies for Experimental Biology (FASEB) 1998-current

Patents Methods for Obtaining Information from Single Cells Within Populations Using DNA Origami Nanostructures Without the Need for Single Cell Sorting. Joseph N. Blattman, Hao Yan, Louis Schoettle, Xixi Wei U.S. patent no. 20160122752 granted 5/5/2016.

Licensed: (2014) GigaGen, Inc., 409 Illinois Street, San Francisco, CA 94158. High Throughput Oil-Emulsion Synthesis of Bowtie Barcodes for Paired mRNA Capture and Sequencing from Individual Cells. Joseph N. Blattman, Louis Schoettle U.S. provisional patent filed 8/19/2016. Antibody Fusion Protein and Related Compositions for Targeting Cancer. Rachael Sirianni, Rebecca McCall, Tsafrir L. Mor, Joseph N. Blattman U.S. provisional patent filed 1/5/2017. Presentations Invited Departmental Seminars/Plenary Talks/Symposium Talks International 1. 9th World Congress and Expo on Immunology, Atlanta, GA, 2-3 November 2017. “Single Cell Analysis of T

Cell Receptors Without Single Cell Sorting (tentative)” 2. NGS, RNA-Seq, Single-Cell Analysis & Single-Molecule Analysis: 2017, Coronado Island, CA, 5-6 October

2017. “Single Cell Analysis of T Cell Receptors Without Single Cell Sorting (tentative)” 3. Universidad de los Andes, Bogata, Columbia, 17 October 2016. “Quantitative Models for Immunity and

Immunopathology”


4. 5th Infectious Diseases World Summit, Catamaran Resort, San Diego CA, 1 June 2016. “Quantitative Models for Immunity and Immunopathology”

5. Immunogenomics 2014, HudsonAlpha Biotechnology Campus, Huntsville AL, 1 October 2014. “Single Cell Analysis of T Cell Receptors Without Single Cell Sorting”

6. 1st International and Interdisciplinary Workshop on the Ecology, Evolution and Dynamics of Dengue and Other Related Diseases, The Biodesign Institute, Arizona State University, Tempe AZ, 4 August 2014. “An Immuno-Epidemiological Model for Virus Infectivity, Disease, and Transmission”

7. 7th Illumina Sequencing Expert Panel 2013, Hotel Monaco, Seattle, WA, 20 June 2013. “Illumina Paired-End Deep Sequencing Using of DNA Origami Nanostructure Templates to Directly Measure TCRαβ Diversity”

8. Technological Innovations in Immunology-1 (session co-chair), American Association of Immunologists 100th Annual Meeting: IMMUNOLOGY 2013, Honolulu, HI, 4 May 2013. “Single Cell Analysis of Gene Expression”

9. 2nd Conference on Systems Approaches in Immunology: Advances and Challenges in Multi-Scale Modeling, Center for Nonlinear Studies, Los Alamos National Laboratories, Santa Fe, NM, 7 January 2012. “Protective vs Pathologic T Cell Immunity”

10. Novel Vaccines: Adjuvants & Delivery Systems / ImVacS–the Immunotherapeutics & Vaccine Summit, Cambridge, MA, August 17-18, 2011. “All-Trans Retinoic Acid Promotes Increased Effector T Cells at Mucosal Sites and Increased Central Memory Systemic T Cells During Vaccination”

11. RAPIDD Workshop on Generation and Maintenance of Immune Memory: Immunologic Models and Epidemiological Consequences, Fred Hutchinson Cancer Research Center, Seattle, WA, 7-8 March 2011. “Immunologic Memory: Balancing Vaccine-Induced Protection vs. Pathology”

12. Collaboration for AIDS Vaccine Discovery Annual Meeting, Seattle, WA, 2 Dec 2010. “Strategies for Enhancing the Breadth of T Cell Responses and Targeting Protective Epitopes during HIV Vaccination”

13. Collaboration for AIDS Vaccine Discovery Annual Meeting, Miami, FL, 2 Dec 2009. “Development of TCR-Transgenic Mouse Models for Evaluating Vaccine-Induced T Cell Immunity”

14. Department of Immunobiology, King’s College, London, England, 26 Oct 2009. “Epitope Immunodominance of T Cell Responses are Dictated by Priming Hierarchy”

15. AIDS Vaccine 2009, Paris, France, 22 Oct 2009. “Development of HIV-specific TCR-transgenic Mouse Models”

16. Collaboration for AIDS Vaccine Discovery Annual Meeting, Seattle, WA, 4 Dec 2008.“Comparison of the Immunogenicity of Adeno-Associated Viral Vectors Expressing Antigen-Flagellin Fusion Proteins”

17. Collaboration for AIDS Vaccine Discovery Annual Meeting, Seattle, WA, 3 Dec 2008.“DNA Immunization: Surprisingly Efficient Induction of Mucosal T Cell Responses Occurs Independent of TLR9 Signals” å

18. Collaboration for AIDS Vaccine Discovery Annual Meeting, Lausanne, Switzerland, 5 Dec 2007. “Validation of a Mouse Model for Assessing the Magnitude and Distribution of CD4 and CD8 T-Cell Responses to Multiple Candidate Vaccine Vectors”

19. Grand Challenges in Global Health, Grand Challenge 4: Devise Reliable Testing Systems for New Vaccines, Scientific Progress Meeting, Washington DC, 7 Oct 2006.“Use of Humanized Mouse Models to Evaluate and Improve the Immunogenicity of Candidate HIV Vaccines”

20. CIS Symposium: Immunity to Latent/Chronic Viral Infections, Immunology 2000, AAI/CIS Joint Annual National Meeting, Seattle, WA, 14 May 2000. “IL-2 Therapy During Viral Infection”

National 21. Cooperation & Conflict Symposium, Tempe, AZ, 16 February 2017. “How do Viruses Cooperate with their

Hosts to be LESS Pathogenic?” 22. Department of Immunobiology, University of Arizona, Tucson, AZ 18 March 2016. “Linking Hemorrhagic

Fever Virus Immunology and Epidemiology”. 23. Department of Microbiology and Immunology, University of Nevada, Reno, NV, 6 June 2012. “Linking

Immunological and Epidemiological Measures of Vaccine Efficacy” 24. Department of Biology, Emory University, Atlanta, GA, 25 August 2011. “Ignorance, Exhaustion, and Death:

Understanding the Balance Between Protective and Pathologic T Cell Immunity” 25. Microbiology Department, Oregon State University, Corvalis, OR, 16 May 2011.“Ignorance, Exhaustion, and

Death: Understanding the Balance Between Protective and Pathologic T Cell Immunity” 26. School of Life Sciences, Arizona State University, Tempe, AZ, 31 March 2011.“Ignorance, Exhaustion, and

Death: Understanding the Balance Between Protective and Pathologic T Cell Immunity”


27. Workshop on the Immunological Basis of Vaccine Efficacy, Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, 14 Dec 2009. “The Problem with Persistent Viral Infections”

28. Emory Vaccine Center, Emory University, Atlanta, GA, 14 Nov 2008. “DNA Immunization: Surprisingly Efficient Induction of Mucosal T Cell Responses Occurs Independent of TLR9 Signals”

29. Program in Molecular and Cellular Biology, School of Medicine, University of Nevada, Reno, NV, 19 Sept 2005. “Ignorance Exhaustion and Death; T Cell Fate and Function During Chronic Viral Infection”

Regional 30. Department of Immunology, Mayo Clinic, Scottsdale, AZ, 31 October 2013. “A Quantitative Understanding of

Vaccination for Disease” 31. Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, 20 August 2013. “A DNA

Origami Deep Sequencing Approach to Directly Measure Total TCR Diversity” 32. American Society for Microbiology, Arizona and Southern Nevada Chapter 51st Annual Meeting, Arizona

State University, Tempe, AZ, 21 April 2012. “A Quantitative Understanding of Vaccination for Disease” Local 33. NSF Science and Technology Centers (STC) Discussion, Tempe, AZ, 23 February 2017. “Big Idea: An

Ethics-Based Collaborative Network for Emerging Infectious Disease Research” 34. Biodesign Chalk Talk Series, Arizona State University, Tempe, AZ, 6 February 2017. “NanoChips for

Analyzing Single Cell Heterogeneity in Cancer and Immunity” 35. Select Agent Training, Arizona State University, Tempe, AZ, 14 March 2016. “Lymphocytic Choriomeningitis

Virus: Immunology Insights from a Human Pathogen” 36. Select Agent Training, Arizona State University, Tempe, AZ, 3 March 2016. “Lymphocytic Choriomeningitis

Virus: Immunology Insights from a Human Pathogen” 37. DACT In-Service Seminar Series, Arizona State University, 12 August 2015. “Lymphocytic Choriomeningitis

Virus (LCMV): Animal Models and Human Infections” 38. School of Life Sciences Seminar Series, A Discussion with the Biomedicine and Biotechnology Faculty

Group, Arizona State University, Tempe, AZ 1 May 2015. “An Eco-Immunological Approach to Understanding Virus Transmission and Disease”

39. Select Agent Training, Arizona State University, Tempe, AZ 24 March 2015. “Lymphocytic Choriomeningitis Virus: Immunology Insights from a Human Pathogen”

40. Fusion 2015, Biodesign Institute Retreat, Cave Creek Resort & Conference Center, Cave Creek, AZ, 21 March 2015. “Understanding Diversity in Cancer and Immunity Using DNA Origami Nanostructures”

41. Select Agent Training, Arizona State University, Tempe, AZ 3 March 2015. “Lymphocytic Choriomeningitis Virus: Immunology Insights from a Human Pathogen”

42. Dublin City University/Arizona State University Joint Symposia, Tempe, AZ, 13 January 2014. “Single Cell Sequencing Without Single Cell Sorting”

43. Sigma Xi, The Scientific Research Honor Society, Arizona State University Chapter, Fall 2013 Luncheon and Lecture, Tempe, AZ, 14 November 2013. “Balancing Immune Diversity versus Immune Protection”

44. Arizona State University School of Life Sciences Graduate Student Retreat, The Phoenix Zoo, Phoenix, AZ, 20 October 2013.“How to Interview for an Academic Position (or How I Learned to Be the Bomb)”

45. Industrial Liaison Program Symposia, Session on Human Health, The Biodesign Institute, Arizona State University, Tempe, AZ, 27 September 2013. “Nanostructure linkage of T cell receptor mRNA for single cells without single cell sorting”

46. Keynote Speaker, Arizona State University Environmental Health & Safety Summer Compliance Officer (CO) Orientation, Arizona State University, Tempe, AZ, 25 July 2013. “Lymphocytic choriomeningitis virus: Immunology Insights from a Human Pathogen”

47. Microdevils, ASU Microbiology Club, Arizona State University, Tempe, AZ, 5 October 2012. “Ignorance Exhaustion and Death – Punk Rock as Preparation for Science”

48. Molecular and Cellular Biology Program Colloquium, Arizona State University, Tempe, AZ, 30 August 2012. “Increasing All-Trans Retinoic Acid Signaling during Vaccination to Improve Mucosal and Systemic Immunity”

49. Department of Basic Medical Sciences, College of Medicine, University of Arizona, Phoenix, AZ, 1 September 2011. “Altering the Balance Between Protective and Pathologic Vaccine-Induced Immune Responses”


50. Vaccine & Infectious Diseases Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, 9 Oct 2009.“Abrogating Cbl-b in Antigen-Specific Effector CD8 T Cells Improves Ant-Viral Immune Responses and Adoptive Therapy of Disseminated Leukemia”

51. Vaccine & Infectious Diseases Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, 16 July 2008. “Use of TLR9 “Humanized” Mouse Models to Evaluate Immunogenicity of DNA Vaccines”

52. Vaccine & Infectious Diseases Institute Inaugural Symposia, Fred Hutchinson Cancer Research Center, Seattle, WA, 16 July 2007.“A Quantitative Mouse Model to Evaluate and Improve the Immunogenicity of Candidate HIV Vaccines”

Community Service Presentations 53. Night of the Open Door, The Biodesign Institute, Arizona State University, Tempe, AZ, 28 Feb 2015. “Show

me Your T Cell Receptor” 54. Spirit of the Senses Art Salon Seminar Series, Phoenix, AZ, 20 May 2014. “The Immune Assault on Virus

Infection” 55. Spirit of the Senses Art Salon Seminar Series, Phoenix, AZ, 17 September 2013. “What is a virus? Platform talks (including by ASU trainees✪ or UW trainees★) 1. Franco LS✪, Blattman JN, Mujica V, §Garcia AA, Gold Nanoparticles Linked to Virus-Specific Antibodies for

Rapid Detection of Viruses, The American Association of Immunologists Annual Meeting: IMMUNOLOGY 2016, Seattle, WA, 16 May 2016.

2. Meador LR, Kessans SA, Kilbourne J, Denzler KL, Kibler KV, Blattman JN, Jacobs BL, §Mor TS, Optimization and characterization of an HIV vaccine using replicating vaccinia virus and plant-producing Gag and dgp41 virus-like particles, Virus-Like Particle and Nano-Particle Vaccines, Salk Institute for Biological Studies, La Jolla, CA, 5 June 2014.

3. Schoettle LM✪, Wei X, Yan H, §Blattman JN, A Direct Measure of TCR Diversity Using DNA Origami Nanostructures, The American Association of Immunologists Annual Meeting: IMMUNOLOGY 2014, Pittsburgh, PA, 2 May 2014.

4. Schoettle LM✪, Wei X, Yan H, §Blattman JN, Development of DNA origami nanostructure for isolation of TCR alpha and beta mRNA from Individual Cells, The American Association of Immunologists Annual Meeting: IMMUNOLOGY 2013, Honolulu, HI, 5 May 2013.

5. Bruce CA✪, Holechek SA✪, Antia R, §Blattman JN, Modeling Lymphocytic Choriomeningitis Virus Epidemiology, American Society for Microbiology, Arizona and Southern Nevada Chapter 52nd Annual Meeting, University of Arizona, Tucson, AZ, 13 April 2013.

Poster Presentations (including by ASU trainees✪ or UW trainees★) 1. Franco LS✪, Blattman JN, Mujica V, §Garcia AA, Gold Nanoparticles Linked to Virus-Specific Antibodies for

Rapid Detection of Viruses, The American Association of Immunologists Annual Meeting: IMMUNOLOGY 2016, Seattle, WA, 16 May 2016 (selected for oral presentation).

2. Morrow KN✪, Holechek SA✪, §Blattman JN, Establishing a Mouse Model for Congenital LCMV Infection, 23rd Annual Undergraduate Research Poster Symposium, Arizona State University, Tempe, AZ, 15 April 2016.

3. Miller CK✪, Holechek SA✪, §Blattman JN, Linking Immunologic and Epidemiologic Models of Virus Transmission and Susceptibility, 23rd Annual Undergraduate Research Poster Symposium, Arizona State University, Tempe, AZ, 15 April 2016.

4. Franco LS✪, Holechek SA✪, Caplan M, §Blattman JN, Sequence-Specific Detection of Different Strains of LCMV in a Single Sample Using Tentacle Probes, 55th Annual Meeting of the American Society for Microbiology, Arizona/Southern Nevada Chapter, Arizona State University, Tempe, AZ, 16 April 2016.

5. Tillis B✪, Holechek SA✪, Newbern J, §Blattman JN, Examining Neurological Development during Vertical LCMV Infection, 55th Annual Meeting of the American Society for Microbiology, Arizona/Southern Nevada Chapter, Arizona State University, Tempe, AZ, 16 April 2016.

6. Miller CK✪, Holechek SA✪, §Blattman JN, Quantifying the Effect of Anti-Viral Vaccination by Memory CD8+ T Cells, 55th Annual Meeting of the American Society for Microbiology, Arizona/Southern Nevada Chapter, Arizona State University, Tempe, AZ, 16 April 2016.


7. Burbidge JP✪, Manhas K✪, §Blattman JN, Modulating T Cell Homing and Differentiation via Culturing with Vitamin A Analogues, 55th Annual Meeting of the American Society for Microbiology, Arizona/Southern Nevada Chapter, Arizona State University, Tempe, AZ, 16 April 2016.

8. Morrow KN✪, Holechek SA✪, §Blattman JN, Establishing a Mouse Model for Congenital LCMV Infection, 55th Annual Meeting of the American Society for Microbiology, Arizona/Southern Nevada Chapter, Arizona State University, Tempe, AZ, 16 April 2016.

9. Appel N✪, Labban N✪, Cook RM✪, §Blattman JN, Combination Therapy for Pediatric Metastatic Osteosarcoma, 55th Annual Meeting of the American Society for Microbiology, Arizona/Southern Nevada Chapter, Arizona State University, Tempe, AZ, 16 April 2016.

10. Franco LS✪, Holechek SA✪, Caplan M, §Blattman JN, Sequence-Specific Detection of Different Strains of LCMV in a Single Sample Using Tentacle Probes, Fusion 2016: A Biodesign Scientific Retreat, Carefree Resort & Conference Center, Carefree, AZ, 1 April 2016.

11. Schoettle LN✪, Yan H, §Blattman JN, Quantitating the Funtional TCRab Repertoire Using DNA Origami Nanostructures, Fusion 2016: A Biodesign Scientific Retreat, Carefree Resort & Conference Center, Carefree, AZ, 1 April 2016.

12. Woolf EC, Johnson JL✪, Lussier DM✪, Brooks KS, Blattman JN, §Scheck AC, The ketogenic diet enhances immunity in a mouse model of malignant glioma, American Association for Cancer Research Annual Meeting, Pennsylvania Conference Center, Philadelphia, PA, 20 April 2015.

13. Poindexter ME✪, Schoettle LN✪, Yan H, §Blattman JN, Development and Use of DNA Origami Nanostructures: Single-Cell Analysis of Paired γδTCR mRNA, American Society for Microbiology, Arizona and Southern Nevada Chapter 53rd Annual Meeting, Northern Arizona University, Flagstaff, AZ, 18 April 2015.

14. Poindexter ME✪, Schoettle LN✪, Yan H, §Blattman JN, Development and Use of DNA Origami Nanostructures: Single-Cell Analysis of Paired γδTCR mRNA, Barrett, The Honor’s College, Celebrating Honors Symposium, Arizona State University, Tempe, AZ, 14 April 2015.

15. Miller CK✪, Guzman VP✪, Holechek SA✪, §Blattman JN, Earliest Detection of Systemic Lymphocytic Choriomeningitis Virus Infection after Exposure to Congenital Carrier Mice, 22nd Annual Undergraduate Research Poster Symposium, Arizona State University, Tempe, AZ, 4 April 2015.

16. Franco LS✪, Guzman VP✪, Holechek SA✪, Caplan M, §Blattman JN, Sequence-specific detection of RNA viruses using tentacle probes, Tropical Infectious Diseases, Gordon Research Conference on Tropical Infectious Diseases; Challenges, Opportunities and Successes, Galveston, TX, 10 March 2015.

17. Franco LS✪, Guzman VP✪, Garcia A, Blattman JN, §Mujica V, Detection of RNA Viruses Using Antibody-Conjugated Gold Nanoparticles, Arizona State University Biochemistry & Chemistry Symposia, Tempe, AZ 28 February 2015.

18. Guzman VP✪, Holechek SA✪, Nieves LM✪, Lussier DM✪, §Blattman JN, Chronic Viral Infections: Decoding the Mystery of LCMV Transmission Using Immunological and Epidemiological Models, 2014 Annual Biomedical Research Conference for Minority Students (ABRCMS), San Antonio, TX, 15 November 2014.

19. §Hingorani P, Lussier DM✪, O’Neill L✪, Nieves LM✪, Holchek SA✪, McAfee MS✪, Dickman P, Blattman JN, Enhancement of T-cell immunity to osteosarcoma by modulation of PD-1/PD-L1 interaction, Connective Tissue Oncology Society 2014 Annual Meeting, Intercontinental Berlin Hotel, Berlin, Germany, 17 October 2014.

20. Franco LS✪, McAfee MS✪, Holechek SA✪, Garcia A, §Blattman JN, Detection of RNA Viruses using Antibody-Conjugated Gold Nanoparticles, 1st International and Interdisciplinary Workshop on the Ecology, Evolution and Dynamics of Dengue and Other Related Diseases, Tempe, AZ, 4 August 2014.

21. Nieves LM✪, Holechek SA✪, McAfee MS✪, Frear C✪, §Blattman JN, ATRA as a Vaccine Adjuvant to Enhance CD8+ T Cell Responses specific to HIV Gag Proteins and Mucosal Protection from Viral Challenge, 1st International and Interdisciplinary Workshop on the Ecology, Evolution and Dynamics of Dengue and Other Related Diseases, Tempe, AZ, 4 August 2014.

22. Johnson J✪, McAfee MS✪, Hyung T, Jacobs BJ, §Blattman JN, Modulation of Virus Replication, Immunity and Disease During Heterologous Co-Infection, 1st International and Interdisciplinary Workshop on the Ecology, Evolution and Dynamics of Dengue and Other Related Diseases, Tempe, AZ, 4 August 2014.

23. Guzman VP✪, Holechek SA✪, Nieves LM✪, Lussier DM✪, §Blattman JN, Chronic Viral Infections: Decoding the Mystery of LCMV Transmission Using Immunological and Epidemiological Models, 1st International and Interdisciplinary Workshop on the Ecology, Evolution and Dynamics of Dengue and Other Related Diseases, Tempe, AZ, 4 August 2014.


24. Manhas K✪, Nieves LM✪, Holechek SA✪, McAfee MS✪, §Blattman JN, Programming Effector T cells for Homing to Epithelial Sites of Virus Transmission, 1st International and Interdisciplinary Workshop on the Ecology, Evolution and Dynamics of Dengue and Other Related Diseases, Tempe, AZ, 4 August 2014.

25. McKay J, Contreras C, Holechek SA✪, Blattman JN, §Castillo-Chavez C, Modeling the Lymphocytic Choriomeningitis Virus: Insights into understanding its epidemiology in the wild, 1st International and Interdisciplinary Workshop on the Ecology, Evolution and Dynamics of Dengue and Other Related Diseases, Tempe, AZ, 4 August 2014.

26. Chowell Puente D, Sundaresan SK, Tan X★, Becker P, Klavinskis L, Greenberg PD, Blattman JN, §Anderson K, A Novel Neuro Network Prediction of MHC-I Immunogenicity for 3 HIV-1 Isolates, 1st International and Interdisciplinary Workshop on the Ecology, Evolution and Dynamics of Dengue and Other Related Diseases, Tempe, AZ, 4 August 2014.

27. Joshi A✪, Reed A✪, Galloway E✪, Schoettle LN✪, Wei X, Yan H, §Blattman JN, Development of DNA Origami Nanostructures for Analysis of Polyclonal TCRγδ, AZBIO Expo, Scottsdale Conference Center and Resort, Scottsdale, AZ, 19 June 2014.

28. Meador LR, Kessans SA, Kilbourne J, Denzler KL, Kibler KV, Blattman JN, Jacobs BL, §Mor TS, Optimization and characterization of an HIV vaccine using replicating vaccinia virus and plant-produced Gag and dgp41 virus-like particles, VIRUS-LIKE PARTICLE & NANO-PARTICLE VACCINES, Salk Institute for Biological Studies, La Jolla, CA, USA, 4-6 June 2014

29. Schoettle LN✪, Garcia-Neuer MI✪, Johnson P, Antia R, §Blattman JN, DNA Origami – Single Cell Analysis of T Cell Receptors Without Single Cell Sorting, The American Association of Immunologists Annual Meeting: IMMUNOLOGY 2014, Pittsburgh, PA, 2 May 2014.

30. Chowell Puente D, Sundaresan SK, Tan X★, Becker P, Klavinskis L, Greenberg PD, Blattman JN, §Anderson K, A Novel Neuro Network Prediction of MHC-I Immunogenicity for 3 HIV-1 Isolates, The American Association of Immunologists Annual Meeting: IMMUNOLOGY 2014, Pittsburgh, PA, 2 May 2014.

31. Jarvis J✪, McAfee MS✪, Suresh M, Ahmed R, Greenberg PD, §Blattman JN, The Role of Tumor Necrosis Factor Receptors p55 and p75 in Acute IL-2 Toxicity in Chronic Viral Infections, 13th Annual Celebrating Honors Symposium of Thesis and Creative Projects, Barrett, The Honor’s College, Arizona State University, Tempe, AZ, 9 April 2014.

32. Guzman VP✪, Holechek SA✪, Nieves LM✪, Lussier DM✪, §Blattman JN, Chronic Viral Infections: Decoding the Mystery of LCMV Transmission Using Immunological and Epidemiological Models, American Society for Microbiology, Arizona and Southern Nevada Chapter 53rd Annual Meeting, University of Nevada-Las Vegas, Las Vegas, NV, 5 April 2014.

33. Nieves LM✪, Holechek SA✪, §Blattman JN, 1,25(OH)3D3 as a Vaccine Adjuvant, American Society for Microbiology, Arizona and Southern Nevada Chapter 53rd Annual Meeting, University of Nevada-Las Vegas, Las Vegas, NV, 5 April 2014.

34. Nieves LM✪, Holechek SA✪, §Blattman JN, 1,25(OH)3D3 as a Vaccine Adjuvant, 21st Annual Undergraduate Research Poster Symposium, Arizona State University, Tempe, AZ, 4 April 2014.

35. Garcia-Neuer MI✪, Schoettle LN✪, Johnson P, Robins H, Antia R, §Blattman JN, The Public Versus Private Nature of Naïve T Cell Receptor Gene Recombination Profiling, 21st Annual Undergraduate Research Poster Symposium, Arizona State University, Tempe, AZ, 4 April 2014.

36. Frear C✪, Holechek SA✪, McAfee MS✪, Nieves LM✪, Guzman VP✪, §Blattman JN, RALDH2 as a Mucosal Adjuvant for DNA-Based HIV Vaccines, 21st Annual Undergraduate Research Poster Symposium, Arizona State University, Tempe, AZ, 4 April 2014.

37. Miller CK✪, Guzman VP✪, Holechek SA✪, §Blattman JN, First Evidence of Lymphocytic Choriomeningitis Virus in Peromyscus maniculatus Sampled from the Walker River Basin of Nevada and California, 21st Annual Undergraduate Research Poster Symposium, Arizona State University, Tempe, AZ, 4 April 2014.

38. Guzman VP✪, Holechek SA✪, Nieves LM✪, Bruce CA✪, §Blattman JN, Role of CD4+ T-Cell Help in Maintaining CD8 T-Cells and B-Cells in Suppression of LCMV Transmission, SOLUR 2014

39. Garcia-Neuer MI✪, Schoettle LN✪, Johnson P, Robins H, Antia R, §Blattman JN, The Public Versus Private Nature of Naïve T Cell Receptor Gene Recombination Profiling, The American Association for the Advancement of Science, Chicago, IL, 13 February 2014.

40. Lussier DM✪, Nieves LM✪, McAfee MS✪, Hyunh TP, Holecheck SA✪, Hingorani P, §Blattman JN (2013) Enhancement of T Cell Immunity to Osteosarcoma through Modulation of PD-1/PD-L1 Interactions, 28th Annual Scientific Meeting of the Society for Immunotherapy of Cancer (SITC), National Harbor, MD, 9 November 2013.


41. McAfee MS✪, Johnson PLF, Antia R, §Blattman JN, A Direct Correlation Between Memory Virus-Specific CD8 T Cells Numbers and Virus Inoculum Resulting in Maximal Disease During Virus Infection, The American Association of Immunologists Annual Meeting: IMMUNOLOGY 2013, Honolulu, HI, 5 May 2013.

42. Holechek SA✪, Nieves LM✪, McAfee MS✪, Guzman VP✪, Bruce CA✪, §Blattman JN, Using the Lymphocytic Choriomeningitis Virus Mouse Model of Infection to Link Specific Immune Responses with Epidemiological Outcomes, The American Association of Immunologists Annual Meeting: IMMUNOLOGY 2013, Honolulu, HI, 5 May 2013.

43. Schoettle LN✪, Wei X, Yan H, §Blattman JN (2013) Development of DNA origami nanostructure for isolation of TCR alpha and beta mRNA from Individual Cells, The American Association of Immunologists Annual Meeting: IMMUNOLOGY 2013, Honolulu, HI, 5 May 2013.

44. Bruce CA✪, Holechek SA✪, Antia R, §Blattman JN, Modeling Lymphocytic Choriomeningitis Virus Epidemiology, School of Human Evolution and Social Change, Undergraduate Research Symposium, Arizona State University, Tempe, AZ, 25 April 2013.

45. Garcia-Neuer MI✪, Schoettle LN✪, Johnson PLF, Antia R, §Blattman JN, The Public versus Private Nature of Naïve T Cell Receptor Gene Recombination Profiling, American Society for Microbiology, Arizona and Southern Nevada Chapter 52nd Annual Meeting, University of Arizona, Tucson, AZ, 13 April 2013.

46. Guzman VP✪, Holechek SA✪, Nieves LM✪, Bruce CA✪, §Blattman JN, Role of CD4+ T-Cell Help in Maintaining CD8 T-Cells and B-Cells in Suppression of LCMV Transmission, American Society for Microbiology, Arizona and Southern Nevada Chapter 52nd Annual Meeting, University of Arizona, Tucson, AZ, 13 April 2013.

47. Nieves LM✪, Holechek SA✪, Guzman VP✪, Bruce CA✪, §Blattman JN, Introducing a Lymphocytic Choriomeningitis Virus Transmission Model to Study the Epidemiological Relationships in Chronic Infections, American Society for Microbiology, Arizona and Southern Nevada Chapter 52nd Annual Meeting, University of Arizona, Tucson, AZ, 13 April 2013.

48. Holechek SA✪, Bruce CA✪, §Blattman JN, Linking Immunological and Epidemiological Models of Immunity and Virus Persistence, American Society for Microbiology, Arizona and Southern Nevada Chapter 52nd Annual Meeting, University of Arizona, Tucson, AZ, 13 April 2013.

49. Guzman VP✪, Holechek SA✪, Nieves LM✪, Bruce CA✪, §Blattman JN, Role of CD4+ T-Cell Help in Maintaining CD8 T-Cells and B-Cells in Suppression of LCMV Transmission, ASU SOLUR Undergraduate Research Symposium, Arizona State University, Tempe, AZ, March 29, 2013.

50. Nieves LM✪, Holechek SA✪, Guzman VP✪, Bruce CA✪, §Blattman JN, Introducing a Lymphocytic Choriomeningitis Virus Transmission Model to Study the Epidemiological Relationships in Chronic Infections, 29th Annual ASU SOLUR Undergraduate Research Symposium, Arizona State University, Tempe, AZ, March 29, 2013.

51. Guzman VP✪, Holechek SA✪, Nieves LM✪, Bruce CA✪, §Blattman JN, Role of CD4+ T-Cell Help in Maintaining CD8 T-Cells and B-Cells in Suppression of LCMV Transmission, More Graduate Education @ Mountain States Alliance and Western Alliance to Expand Student Opportunities Conference, Arizona State University, Tempe, AZ, March 4, 2013.

52. Nieves LM✪, Holechek SA✪, Guzman VP✪, Bruce CA✪, §Blattman JN, Introducing a Lymphocytic Choriomeningitis Virus Transmission Model to Study the Epidemiological Relationships in Chronic Infections, More Graduate Education @ Mountain States Alliance and Western Alliance to Expand Student Opportunities Conference, Arizona State University, Tempe, AZ, March 4, 2013.

53. Bruce CA✪, Holechek SA✪, Antia R, §Blattman JN, Modeling Lymphocytic Choriomeningitis Virus Epidemiology, Celebrating Honors Symposium, Barrett Honors College, Arizona State University, Tempe, AZ, 11 April 2013.

54. McAfee MS✪, Johnson PLF, Antia R, §Blattman JN, A Direct Correlation Between Memory Virus-Specific CD8 T Cells Numbers and Virus Inoculum Resulting in Maximal Disease During Virus Infection, Molecular and Cellular Biology Graduate Program Retreat, Arizona State University, Tempe, AZ, 24 August 2012.

55. McAfee MS✪, Stromnes IM★, Johnson PLF, Antia R, §Blattman JN, Both Naïve and Memory Virus-Specific CD8 T Cells Can Mediate Enhanced Pathology During Viral Infection, American Society for Microbiology, Arizona and Southern Nevada Chapter 51st Annual Meeting, Arizona State University, Tempe, AZ, 21 April 2012.

56. Holechek SA✪, Idouraine L✪, McAfee MS✪, St. Jeor SC, §Blattman JN, Assessment of anti-mouse antibodies reactivity against deer mice (Peromyscus maniculatus), American Society for Microbiology, Arizona and Southern Nevada Chapter 51st Annual Meeting, Arizona State University, Tempe, AZ, 21 April 2012.


57. Griffith K✪, McAfee MS✪, LeGall S, §Blattman JN, Defining limitations to Broad T Cell Responses to HIV, American Society for Microbiology, Arizona and Southern Nevada Chapter 51st Annual Meeting, Arizona State University, Tempe, AZ, 21 April 2012.

58. Creevy E✪, McAfee MS✪, Blattman NN, §Blattman JN, Understanding Vaccination for Disease, American Society for Microbiology, Arizona and Southern Nevada Chapter 51st Annual Meeting, Arizona State University, Tempe, AZ, 21 April 2012.

59. Garcia-Neuer MI✪, McAfee MS✪, Johnson PLF, Antia R, §Blattman JN, Using Single-Chain TCR Transgenic Mice to Estimate Total TCRαβ Diversity, American Society for Microbiology, Arizona and Southern Nevada Chapter 51st Annual Meeting, Arizona State University, Tempe, AZ, 21 April 2012.

60. McAfee MS✪, Stromnes IM★, Johnson PLF, Antia R, §Blattman JN, Both Naïve and Memory Virus-Specific CD8 T Cells Can Mediate Enhanced Pathology During Viral Infection, 2nd Conference on Systems Approaches in Immunology: Advances and Challenges in Multi-Scale Modeling, Center for Nonlinear Studies, Los Alamos National Laboratories, Santa Fe, NM, 7 January 2012.

61. Larrimore K★, Blattman JN, §Greenberg PD, Neutralizing Antibody and Germline Precursor Knock-In Mice to Facilitate HIV-1 Vaccine Development, Collaboration for AIDS Vaccine Discovery Annual Meeting Seattle, WA, 2 Dec 2010.

62. Scherer EM★, Vogt J, Spies G, Greenberg PD, §Blattman JN, A Recombinant Yellow Fever Virus Vaccine Expressing an SIV Gag Protein Induces B- and T-Cell Immunity in Murine Model, Collaboration for AIDS Vaccine Discovery Annual Meeting Seattle, WA, 2 Dec 2010.

63. Tan X★, Blattman JN, Sande JL★, Pufnock J★, Bergthaler A, §Greenberg PD, Retinoic Acid as an Adjuvant During Systemic Vaccination Enhances Protection from Mucosal Viral Challenge, Collaboration for AIDS Vaccine Discovery Annual Meeting Seattle, WA, 2 Dec 2010.

64. Tan X★, Blattman JN, Sande JL★, §Greenberg PD, All-Trans Retinoic Acid as an Adjuvant can Imprint Mucosal Homing Properties to Vaccine-Induced T Cells, AIDS Vaccine 2009, Paris, France, 22 October 2009.

65. §Blattman JN, Tan X★, Sande JL★, Pufnock J★, Greenberg PD, All-Trans Retinoic Acid During Vaccination Increases Antigen-Specific CD8 T Cell Homing to Mucosal Sites and Improves Recall Responses to Vaginal Challenge, AIDS Vaccine 2009, Paris, France, 22 October 2009.

66. Schietinger A★, Fowler CC★, Teague RM, Tan X, Blattman JN, §Greenberg PD, Homeostatic Proliferation Transiently Rescues Tolerant CD8+ T Cells, American Association of Immunologists 2009, April 2009.

67. Stromnes IM★, Tan X, Blattman JN, §Greenberg PD, Cbl-b-Deficiency in Tumor Reactive CD8+ T Cells Improves Efficacy and Bypasses the Requirement for IL-2 Administration During Adoptive Therapy of Progressive Leukemia, American Association of Immunologists 2009, April 2009.

68. Tan X★, Blattman JN, §Greenberg PD, Retinoic Acid as an Adjuvant to Imprint Mucosal Homing Properties to Vaccine-Induced T Cells, American Association of Immunologists 2009, April 2009.

69. Fowler CC★, Pao L, Schietinger A★, Tan X, Blattman JN, §Greenberg PD, SHP-1 Regulation of In Vivo CD8 T Cell Responses, American Association of Immunologists 2009, April 2009.

70. Tan X★, Blattman JN, §Greenberg PD, Retinoic Acid Receptor Signaling is Involved in Homing of CD8+ T Cells to Gut Associated Lymphoid Tissues, Amgen/FHCRC/UW 12th Annual Joint Symposium, Bell Harbor International Conference Center, Seattle, WA, 2 May 2008.

71. §Blattman JN, Jeevanjee S, Greenberg PD, Enhanced T Cell Responses to Viral Infection in Cbl-b Deficient Mice, Amgen/FHCRC/UW 9th Annual Joint Symposium, Bell Harbor International Conference Center, Seattle, WA, 6 May 2005.

72. Wherry EJ, Barber DL, Kaech SM, Blattman JN, §Ahmed R, Antigen-Independent Memory CD8 T Cells do Not Develop During Chronic Viral Infection, FASEB 2005, 4 March 2005.

73. Blattman JN, Zajac AJ, §Ahmed R. Ignorance, Exhaustion and Death: Continued Antigen Recognition Determines the Fate of Virus-Specific CD8 T Cells during Chronic Infection, Keystone Symposia: Immune Evasion, Taos, NM, 27 March 2004.

74. Blattman JN, Jeevanjee S, §Greenberg PD. Enhancing CD8 T cell IL-2 Production and Proliferation by Abrogation of Cbl-b, Keystone Symposia: Basic Aspects of Tumor Immunology, Keystone, CO, 18 Feb 2003.

75. Blattman JN, Ahmed R, §Antia R, Estimating the Precursor Frequency of Naïve Antigen-Specific CD8 T Cells In Vivo, FASEB 2001, Hematopoeisis & Immune System Development, Orlando, FL, 4 April 2001.

76. Blattman JN, Sourdive DJD, §Ahmed R, Evolution of the T Cell Repertoire During Primary, Memory, and Recall Responses to Viral Infection, Keystone Symposia: T Lymphocyte Activation, Differentiation and Death, Keystone, CO, 29 Jan 2000.


Other / Creative Performances 1. Solo Flamenco Guitar, Spirit of the Senses Art Salon Seminar Series, Tempe, AZ, 7 Oct 2015. 2. Solo Flamenco Guitar, Fusion 2015, The Biodesign Institute Retreat, Cave Creek, AZ, 21 Mar 2015. 3. Solo Flamenco Guitar, Amenzone Foundation Event to Fight Childhood Obesity, Scottsdale, AZ, 19 Feb 2015. 4. Solo Flamenco Guitar, Night of the Open Door 2014, The Biodesign Institute, Arizona State University, Tempe,

AZ, 1 Mar 2014. 5. Solo Flamenco Guitar, Amenzone Foundation Event to Fight Childhood Obesity, Scottsdale, AZ, 28 Oct 2013. 6. Solo Flamenco Guitar, ASU School of Life Sciences Winter Party, Arizona Historical Society Museum, Tempe,

AZ, 6 Dec 2012. 7. Member, Un Corazón Flamenco, Guitarrista, Tempe, AZ, 2012-2015. 8. Solo Flamenco Guitar, ASU Staff Artfest 2012, Union Stage, ASU Memorial Union, Arizona State University,

Tempe, AZ, 9 Aug 2012. 9. Solo Flamenco Guitar, Night of the Open Door 2012, The Biodesign Institute, Arizona State University, Tempe,

AZ, 3 Mar 2012. 10. Member, Lunares Flamenco, Guitarrista, Seattle, WA, 2009-2011.


References

Dr. Rafi Ahmed, Ph.D. Director, Emory Vaccine Center Georgia Research Alliance Eminent Scholar Professor of Microbiology and Immunology Emory University School of Medicine 1510 Clifton Rd. Rollins Research Bldg, G211 Atlanta, GA 30322 (404) 727-4700 (404) 727-3722 (fax) [email protected]

Dr. Philip D. Greenberg, M.D. Professor of Immunology and Medicine (Oncology) Director, Immunology Program, UW Center for AIDS Research University of Washington Head, Division of Immunology Fred Hutchinson Cancer Research Center 1100 Fairview Ave. N., D3-100 P.O. Box 19024 Seattle, WA 98109-1024 (206) 667-4462 (206) 667-7983 (fax) [email protected] Dr. Kendall A. Smith, M.D. Rochelle Belfer Professor of Medicine & Immunology Chief, Division of Immunology Department of Medicine Weill Medical College Cornell University 515 East 71st St, S-208 New York, NY 10021 (212) 746-4464 (212) 746-8167 (fax) [email protected] Dr. Rustom Antia, Ph.D. Samuel C. Dobbs Professor of Biology Department of Biology Emory University 1510 Clifton Rd. Atlanta, GA 30322 (404) 727-1015 (404) 727-2880 (fax) [email protected]

joseph n blattman, ph.d. - home page | the … dr. rafi ahmed, phd b.s. with distinction,...

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