journal article review (2)

8/3/2019 Journal Article Review (2)

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Journal article review

By:

Dr Haresh E. Memane

Final year P.G. Scholar

Department of Dravyaguna


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Contents

Objectives of seminar

Article

Scope of article

Abstract

Introduction

Critical analysis

Own research view

Summary

Conclusion

2/1/2012 2Journal article review


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Objectives

To review the article critically.



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Title

SOME IMPORTANTANTICANCER HERBS: AREVIEW

Author

Pandey Govind*

Ex-Professor / Principal Scientist & Head ofPharmacology

(Pharmacy); presently Officer-In-Charge of RinderPest

(Animal Husbandry Department, Govt. of MP), Jabalpur

Division, Jabalpur, MP, India

Article Received on: 12/05/11 Revised on: 20/06/11 Approved for

publication: 08/07/11



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Abstract

A great deal of pharmaceutical research has

considerably improved the quality of herbal drugs used

against various types of cancer. With the advanced

knowledge of molecular science and the refinement in

isolation and structure elucidation techniques, we are in

a much better position now to identify various anticancer

herbs.



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Cont

Scientists all over the world are concentrating on the use

of herbs to boost immune system of the body against

cancer. Scientists have contributed for a number of years

to identify hundreds of anticancer herbs, and developed

various herbal formulations from their active principles

that inhibit growth and spread of cancer without any sideeffect.

2/1/2012 Journal article review 6


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Cont.

Such herbs possess anticancer, immunoenhancing,

antiangiogenesis, antioxidant and antimutagenic

properties. They inhibit growth and spread of cancer

by modulating the activity of hormones, enzymes

and other biological factors. The therapeutic effect of

these herbs is executed by the complex synergistic

interaction among their various active principles.

Some important anticancer herbs have been

discussed here.2/1/2012 7Journal article review


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KEYWORDS:

Anticancer activities, Cancers, Herbs/medicinal

plants, Phytoconstituents.



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Introduction

Review article contains 35 anticancer herbs (anticancer

medicinal plants).

The general data of these plants have been collected

from some books authored by different authors.

The particular phytoconstituents (phytochemicals)

present in these plants, their mechanism of action and

uses against the various cancers as reported by different

authors have been cited under each medicinal

plant/herb.2/1/2012 9Journal article review


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Cont .

The anticancer activity of the medicinal plants is

because of the presence of certain phytoconstituents,

which possess strong antioxidant activities.

The main phytoconstituent antioxidants with anticancer

activity include vitamins (e.g., A, C, E and K),

carotenoids or carotene, terpenoids, flavonoids,

polyphenols (e.g.ellagic acid, gallic acid and tannins),

flavonoids (e.g.,quercetin, anthocyanins,

catechins,isocatechins,flavones, flavonones and2/1/2012 10Journal article review


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Cont..

Enzymes (e.g. superoxide dismutase, catalase and

glutathion peroxidase), minerals (e.g., selenium, copper,

manganese,zinc,chromiumandiodine),polysaccharides,

alkaloids, saponins, lignins, xanthones and certain

pigments.



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Name of plants Phytochemical Specific actions

Aegle marmelos Correa

Rutaceae

Lupeol Breast cancer, malignant

cancer , malignant

lymphoma, ascites,

leukamia

Allium cepa LinnLiliaceae

Diallyl disulphide,quercetin flavonoids

Inhibit Helicobactor pylori,stomach cancer

Allium sativum Linn

Liliaceae

Sulphur compounds ,

allicin

Stomach , lung, colon,liver,

breast and endometrial

cancer.

Aloe vera Tourn

Liliaceae

Acemannan

( Polysaccharide) , Emodin

Inhibit growth and spread

of stomach cancer.

Alpinia galanga Willd

Zingiberaceae

Acetoxy-chavicol-acetate ,

Galangin

Prostate , multiple

myeloma, leukaemia


Anticancer herbs


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Name of plants Phytochemicals Specific actions

Curcuma longa Linn

Zingiberaceae

Curcumin

( Diferuloyl methane )

Suppress cancer at every

step i.e, initiation , growth,metastasis ( Suppresses

adhesion of cancer cells)

Andrographis paniculata

Wall

Acanthaceae

Andrographolide

( Active diterpine

component )

Breast , ovary, stomach,

colon, prostate,kidney and

nasopharynx

Catharanthus roseus G.

Apocyanaceae

Vinca alkaloids Breast , ovary, cervix,lung,

colon, rectum,kidney and

testis cancers

Emblica officinalis Gaertn

Euphorbiaceae

Ellagic , gallic acid,

quercetin

Breast, uterus,

pancreas,stomach and

malignant ascites

Bauhinia variegata Linn

Caesalpiniaceae

Cyanidin glucosides,

malvinin glucosides

Breast , lung , liver, oral

cavity, larynx.



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Ginkgo biloba Linn.Ginkgoaceae

Ginkgetin , ginkgolides Hepatocellular carcinoma

Viscum album Linn.

Loranthaceae

Lectins Urinary bladder, testis,

leukaemia

Panax ginseng Mey.

Araliaceae

Ginsenosides Prostate,colon,renal cell

carcinoma, malignantmelanoma

Malus domestics Borkh.

Rosaceae

Antioxidant , anticancer

Fragaria vesca Linn.

Rosaceae

Flavonoides , tannins,

borneol

Antioxidant, anticancer



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Nigella sativa Linn.

Ranunculaceae

Thymoquinone,

Diathymoquinone

Colon,prostate,pancreas,ut

erus,sarcomas

Tinospora cordifolia

( Willd) , Menispermaceae

Berbarine , tinosporine Cancer of lung,cervix and

throat.Rubia cordifolia Linn.

Rubiaceae

Rubidianin , rubiadin Breast,ovary,cervix and

lung cancers

Oldenlandia diffusa Roxb.

Rubiaceae

Oldenlandosides, ursolic

acid

Lung,ovary,colon,rectum

and brain

Punica granatum Linn.Punicaceae

Alkaloides ,anthocyanidines

Acts against solid andascites tumour



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Nam

e of plan

ts Phytochem

ica

ls Specifica

ction

sSaussurea lappa C.B.Clarke

Asteraceae

Sesquiterpenes ,

Cynaropicrin

Malignant lymphoma and

leukaemia

Solanum nigrum Linn.

Solanaceae

Quercetin , solamargine,

solamergic

Breast,liver,lung and cyst

cancers

Withania somnifera Dunal

Solanaceae

Withanolides , withaferin Breast,lung,colon,CNS

Plumbago zeylanica Linn.

Plumbaginaceae

Plumbagin Liver cancer,

fibrosarcoma,malignant

ascites and leukamia



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Gycine max Merrill

Fabaceae

Isoflavones , saponins ,

Genistein

Nasopharyngeal

carcinoma, skin cancer,

malignant brain tumours

Glycyrrhiza glabra Linn.

Fabaceae

Triterpenoi saponins Antitumour, lung cancer

and fibrosarcomas

Psoralea corylifolia Linn.

Fabaceae

Bavachinin , corylfolinin Lung,liver,osteosarcoma,

Leukaemia.

Ocimum sanctum Linn.

Labiatae

Ursolic acid ,

polysaccharides

Breast,liver

cancer,sarcomas

Prunella vulgaris Linn.

Labiatae

Ursolic acid , oleanolic acid Oral cavity,oesophagus,

intracranial tumours,Anti-

HIV , immunoenhancing.



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Nam

e of plan

ts Phytochem

ica

ls Specifica

ction

sAphanamaxis polystachya

(Wall) , Meliaceae

Amooranin Multidrug resistant in

breast ,colon cancer and

leukamia

Azadirachta indica A.Juss.

Meliaceae

Liminoids Prostate, stomach and skin

cancers

Berberis vulgaris Linn.

Berberidaceae

Berbarine , berbamine Stomach and oral cavity

cancers

Podophyllum hexandrum

Royle. , Berberidaceae

Podophyllotoxin ,

podophyllin

Urinary bladder, testis,

brain and neuroblastoma.



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Critical analysis

Review article

In vitro and in vivo studies in animals have been carried out

on these herbs.

Anticacer medicinal plants

- 35 anticancers herbs

- Latin name, Local name, Family of herbs

- Based on phytoconstituents.

- Phytoconstituent with antioxidants and anticancer activity.

- Reduces side effects of chemotherapy and radiotherapy.



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Cont .

Maximum herbs from liliaceae,

zingiberaceae,rosaceae,rubiaceae,solanaceae,

fabaceae, labiatae and berberidaceae families.

Antioxidant, hepatoprotective, neuroprotective and

immunoenhancing properties.

Radioprotective and haemopoietic properties.

W. somnifera presents itself as a novel therapy for

cancer.

No discussion and conclusion.2/1/2012 20Journal article review


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Own research view

Clinical studies can be carried out on these herbs.



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Summary



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Conclusion

Anticancer drugs which are mentioned in article mainly

based on phytoconstituents.

Phytoconstituent with antioxidants and anticancer

activity.

Most of the drugs reduces side effects of chemotherapy

and radiotherapy.



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Thank you


journal article review (2)

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