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Journal of Dentistry and Oral Care Review Article Open Access 1 Specialist Prosthodontist, Private dental practice, Dubai 2 Senior Lecturer, Department of Prosthodontics, Bangalore Institute of Dental Sciences, Bangalore Abstract CAD/CAM is a field of dentistry and prosthodontics using CAD/CAM (com- puter-aided design and computer-aided manufacturing) to improve the design and creation of dental restorations, especially dental prostheses, including crowns, crown, veneers, inlays and onlays, fixed bridges, dental implant restorations, dentures (remov- able or fixed), and orthodontic appliances. There exists a misconception that the CAD/CAM process is complicated and time-con- suming. However, the CAD/CAM system is simple to operate, versatile, and precise. All-ceramic restorations can be designed and milled chair side, with the added advan- tage of elimination of traditional impressions and temporaries, and the patient leaves the appointment in about an hour with the final restoration in place. Dental CAD/CAM is approaching 20 years of clinical experience and has a proven track record on all relevant aspects of clinical performance, including fit, longevity and survival rates, sensitivity, strength, and wear. * Corresponding author: Smitha Annie Jacob, Specialist Prosthodontist, Private dental practice, Dubai E-mail: [email protected] Keywords: CAD CAM; Ceramics; Digital Dentistry; Digital Workflow; CEREC Citation: Smitha A.J., et al. CAD CAM - Understanding the Basics: A Review. (2016) J Dent Oral Care 2(2): 50- 55. J Dent Oral Care | Volume 2: Issue 2 Aim The application of dental CAD/CAM systems is promising, not only in the field of crowns and FPDs, but also in other fields of dentistry. There is no doubt that the application of CAD/CAM technology in dentistry provides innovative, state-of-art dental service, and contributes to the health and Quality of Living (QOL) of patients. The purpose of this paper is to give an in-depth knowledge of CAD CAM technology to the readers as today’s dentistry has entered into the digital era. Introduction The term CAD/CAM, which comes from machine-tool technology and stands for “Computer-Aided-Design / Comput- er-Aided-Manufacturing”, designates the three-dimensional planning of a work piece on the screen of a computer with subsequent automated production by a computer controlled machine tool [1,2] . In 1971, Francois Duret introduced CAD-CAM technology to the field of dentistry. His idea was based upon the assumption that the technologies established in industry could be easily transferred to dentistry. Though casting procedure has advanced over the past years, each of its steps could induce error in the final casting. Until 1988, indirect ceramic dental restorations were fabricated by conventional methods (sintering, casting and pressing) and neither was pore-free. Machining blocks of pore-free industrial quality ceramic can alternately produce pore-free restorations [3-5] . The tre- mendous advances in computers and robotics could also be applied to revolutionize dentistry and provide both precision and reduce time consumption. With the combination of optoelectronics, computer techniques and sinter technology, computerized dentistry CAD CAM - Understanding the Basics: A Review Copyrights: © 2016 Smitha A.J. This is an Open access article distributed under the terms of Creative Commons Attribution 4.0 International License. 50 Smitha Annie Jacob 1* , Savitha P.N 2 Received date: August 10, 2016 Accepted date: August 29, 2016 Published date: September 02, 2016 Smitha A.J., et al. DOI: 10.15436/2379-1705.16.1046

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Page 1: Journal of Dentistry and Oral Care › articles › publish... · CAD/CAM is a fieldof dentistry and prosthodontics using CAD/CAM (com-puter-aided design and computer-aided manufacturing)

Journal of Dentistry and Oral Care

Review Article Open Access

1Specialist Prosthodontist, Private dental practice, Dubai2Senior Lecturer, Department of Prosthodontics, Bangalore Institute of Dental Sciences, Bangalore

Abstract

CAD/CAMisafieldofdentistryandprosthodonticsusingCAD/CAM(com-puter-aided design and computer-aided manufacturing) to improve the design and creationofdentalrestorations,especiallydentalprostheses,includingcrowns,crown,veneers,inlaysandonlays,fixedbridges,dentalimplantrestorations,dentures(remov-ableorfixed),andorthodonticappliances.ThereexistsamisconceptionthattheCAD/CAMprocessiscomplicatedandtime-con-suming.However,theCAD/CAMsystemissimpletooperate,versatile,andprecise.All-ceramicrestorationscanbedesignedandmilledchairside,withtheaddedadvan-tage of elimination of traditional impressions and temporaries, and the patient leaves theappointmentinaboutanhourwiththefinalrestorationinplace.DentalCAD/CAMis approaching20yearsof clinical experienceandhas aproven track recordonallrelevant aspects of clinical performance, including fit, longevity and survival rates,sensitivity,strength,andwear.

*Corresponding author: Smitha Annie Jacob, Specialist Prosthodontist, Private dental practice, DubaiE-mail: [email protected]

Keywords:CADCAM;Ceramics;DigitalDentistry;DigitalWorkflow;CEREC

Citation:SmithaA.J.,etal.CADCAM- Understanding the Basics: A Review.(2016)JDentOralCare2(2):50-55.

JDentOralCare|Volume2:Issue2

Aim TheapplicationofdentalCAD/CAMsystemsispromising,notonlyinthefieldofcrownsandFPDs,butalsoinotherfieldsofdentistry.ThereisnodoubtthattheapplicationofCAD/CAMtechnologyindentistryprovidesinnovative,state-of-artdentalservice,andcontributestothehealthandQualityofLiving(QOL)ofpatients.Thepurposeofthispaperistogiveanin-depthknowledgeofCADCAMtechnologytothereadersastoday’sdentistryhasenteredintothedigitalera.

Introduction

ThetermCAD/CAM,whichcomesfrommachine-tool technologyandstandsfor“Computer-Aided-Design/Comput-er-Aided-Manufacturing”,designatesthethree-dimensionalplanningofaworkpieceonthescreenofacomputerwithsubsequentautomatedproductionbyacomputercontrolledmachinetool[1,2].In1971,FrancoisDuretintroducedCAD-CAMtechnologytothefieldofdentistry.Hisideawasbasedupontheassumptionthatthetechnologiesestablishedinindustrycouldbeeasilytransferredtodentistry. Thoughcastingprocedurehasadvancedoverthepastyears,eachofitsstepscouldinduceerrorinthefinalcasting.Until1988,indirectceramicdentalrestorationswerefabricatedbyconventionalmethods(sintering,castingandpressing)andneitherwaspore-free.Machiningblocksofpore-freeindustrialqualityceramiccanalternatelyproducepore-freerestorations[3-5].Thetre-mendousadvancesincomputersandroboticscouldalsobeappliedtorevolutionizedentistryandprovidebothprecisionandreducetimeconsumption.With thecombinationofoptoelectronics,computer techniquesandsinter technology,computerizeddentistry

CAD CAM - Understanding the Basics: A Review

Copyrights: ©2016SmithaA.J.ThisisanOpenaccessarticledistributedunderthetermsofCreativeCommonsAttribution4.0InternationalLicense.

50

Smitha Annie Jacob1*, Savitha P.N2

Received date: August 10, 2016Accepted date: August 29, 2016 Published date: September 02, 2016

SmithaA.J.,etal.

DOI: 10.15436/2379-1705.16.1046

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haspavedthewayforanewgenerationdentalceramicwithanunprecedentedhighstrengthanddurability,derivedfromdevel-opmentsinNano-ceramictechnologiesinthelastdecades.

What is CAD CAM?ThecontemporaryCAD/CAMsystemsconsistofthreecompo-nents: 1.Thescanner,whichscansthedentalpreparationpro-videdbythedentisteitherintra-orallyorextra-orallybyrefer-ence to toothmodels (Figure 1). For inlays and single crownframeworks,justthesurfacedataofthepreparedteethneedtobedigitized.ForFPDframeworksoradditionalocclusalcharacter-ization, further data from the neighboring teeth and antagonists, aswellasfromthespatialrelationofthepreparedteethtooneanother,arerequired[6-9].

Figure 1:CERECScanner.

2.ThesoftwareCADconsistsofacomputerunitusedfor the three-dimensional planning and design of restorations on thecomputerscreen(Figure2).Thesoftwareprogramsavailabletodayoffer a high level of intervention andpermit thedesignandproductionofanindividuallyadaptedrestoration.SystemsnotofferingafullCADcomponentarenotconsideredasCAD/CAMsystemsbutjustasCAMsystems[10].

Figure 2 : Softwaredentaldesigner.

3. The hardware CAM covers different productiontechnologies for converting the virtual restoration into a den-talmaterial(Figure3).Atpresent,computer-controlledmillingorgrindingmachinesaremainlyused.Theymachinetheresto-ration from the fullmaterial block consistingof prefabricatedmetal or ceramic[11,12].Asarule,aftertheCAMproduction,somemanual corrections and final polishing or individualization ofthe restorationwith staining colors or veneeringmaterials arerequiredtobecarriedoutbythedentaltechnician(Figure4).

Figure 3 :SironaMillingUnit.

Figure 4 :CycleofCAD/CAM.

Scanning of Preparation Since1971,anumberofattemptstodentalCAD/CAMhavebeenreported.Themostprominentare

1. Holodontography by altschuler : Areportdated1971claimsthatdevelopmentoflaserholographycansignificantlyinfluencetheproceduresusedindentalcare.Itmentionstheuseoftoothprints recorded bymeans of a combination of computers andlaser holography. Such tooth print could serve for diagnosticand forensic purposes, but also applicable to prosthetic and re-storativework[13].Aspecifictaskwouldbecomputer-controlledmillingofdentalcrownsbasedoncontourholograms.

2. The Duret/ Hennson/ Sopha system :TheoriginofFrench

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approachdatesbacktotheearlyseventies.Goalofthisendeav-oristhecomputer-aidedrestorationanddentistryinthebroad-estsense.Theprimaryapplicationofthesystem,however,wasthefabricationofcrowns.Theoriginalscanningprinciplewasbasedonlaserholography.DrFrançoisDuret’smethodrequiresasetofdifferentviewsofthepreparation.Theindividualviewsarecorrelatedbythecomputertoproduceathree-dimensionalrecord.Tofacilitatethealignment,thedentistplacesreferencebracketswithin thefield of view.Thedesign is accomplishedbymanually tracing thecervicalmarginof thepreparationbymeans of a large screen color monitor and a digitizing tablet[14].Theprogramusesaselectiveshrinkagealgorithmtoproduceanoptimumcementationgap.Themachineisequippedwiththreeaxesandhastheadditionalcapabilitytoturntheworkpieceup-sidedown.

3. Active triangulation:Thisprincipledoesnotrelyonanim-agepairasobtainedbytwo-eyedvision.Insteadoneopticalpathisconvertedfromreceptortotransmitteror,moreaccurately,apatternprojector.Duetothephysicalseparationofthetwochan-nelsacertainamountofparallaxisintroduced.Sincetheparal-laxisaknownconstant,theresultingrange-dependentshiftofthepatternprojectedontotheobjectcanbeaccuratelyconvertedinto depth values[15].

Data Acquisition Thefirstelementofthedataacquisitionchainisasolidstateimagesensor.Thisdeviceaccuratelyconvertslightinten-sitytovoltagewhenreadinalinebylinemode.Thealternatingregionsofdarkandlighttranslateintohigherandlowervoltag-es.Whenreadingasensorline,whichrunsmesio-distally,sinu-soidal pattern is observed[16,17].Whilethereticlefeaturesasquarepattern (bands are either transparent or totally opaque), limit-edresolutionofthedetectedsignalapproximatesasinewave.Justliketheindividualline,everylineofthepatternisshiftedproportionallytoverticaldistances.Inmathematicalterms,thephaseofthespatialfrequencyismodulated. Oncetheparticularphasewhichcorrespondstoaref-erencelevelhasbeenestablishedbycalibration,theelevationofanypointoftheobjectcanbecalculatedfromthephaseshift.Amorecarefulanalysisofthesinusoidalpatternrevealssomeadditionaldifficulties:theshapeofthispatternisnotverywellbehaved.Itexhibitslargelocalvariationsinbothamplitudeandoffseti.e.thedistancefromthebaseline.Thelatterarecausedbythevariousamountsofstraylightandsensordarkcurrent.Theformerarecausedbythefact,thattheamountoflightpickedupbythesensorisafunctionoftheslopeofthepreparationwallsat any point.An additional difficulty arises from the non-uni-formityintheresponseoftheindividualsensorelements.Duetolimitationsintheartofsemiconductorfabrication,atypicalsensorwillevencontainacertainamountofblindcells.Inordertoisolatethethreevariables–phase,magnitudeandoffset-atleast three images are required, all takenwith the exact sameorientation,buteachusingadifferentphaseoftheprojectedpat-tern[18,19]. Asequenceoffourimages(Figure5),provedtobeamoreefficientapproachinourparticularapplicationandhard-wareimplementation.Thereticleisphysicallytranslatedduringaperiodof4times40millisecondsfromanarbitrary0˚initialpositionover 360˚, i.e., one entire line period.For reasonsofclarity, the illustration shows a fixed position for each frame,

whileinrealitythepatterniscontinuouslysweptacrosstheim-age. Various levels of intensity, reflecting the actual positionofpattern,aredetected.Thesignalisasteppedapproximationof theactual intensitypatternsince theelementsof thesensorhave finite dimensions (period of pattern 200µ divided into a22µelementpitchofthesensorarrayyieldsapprox.9samplesperperiod),whilethemodulatedpartofthesignalisshiftedinphase,theoffset,representedbytheaverageintensity,remainsconstant[20,21].Thisobservationsuggestsadifferentialoperation.Subtractingthe180˚imagefromthe0˚imagecancelstheoffsetportion off the signal. Since this subtraction is achieved by areactionofmodify-writeoperation in the imagememory, it isexecutedinstantaneously.The90˚-270˚subtractionisaccom-plishedinthesameway.

Figure 5:Sequenceoffourimages.

At the endof the 160millisecond exposure,we thusfindthetwodifferentialdatasetsintheframebuffer.Thechar-acterizationfeaturesofthemodulationhavebeenunaffectedbythe subtraction, the amplitudes have been doubled and the sig-nalsarenowbiasedatthezerolevel.The90˚phasebetweenthetwosignalshasbeenpreserved.Wearenowleftwithadatapaircorrespondingtoeachpicturecell-orpixel-oftheimage.Datapairsmustbetransformedtoyieldthedesireddepthinformation.Thetwo-dimensionalarrayofthedepthvaluesisreferredtoastheprofile.A second setofvalues, representing local contrastamplitudecanbeobtainedfromthisconversion;inourcontextwecallthissecondsetofdatathehill-shadedimage[22-24]. Priortomakinganopticalimpressionwiththesensor,it isnecessary topowder the toothsurfaceandtheentirefielduniformly.Thedetectionof thepattern cast onto anuntreatedpreparationisnotpossibleforthefollowingreasons:ontheonehandthedifferentslopesofthepreparationandthedifferencesinsurfacequalityyieldadynamicrangeofintensities,whichistoolargetobeaccommodatedbythesensorandtheassociated

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circuitry.Thesteepwallsappearasvirtuallyblackregions.Thecuspwhichreflecttheincidentlightinaspecularfashiontendtoglaretherebycausingsmearingartifactssimilartothehumanretinawhenwelookdirectly intoapowerful lightsource[25,26].Ontheotherhandthedentinandenamelistranslucentwherebyit absorbs at least partially, the pattern projected onto its sur-face.Toalleviatebothproblems,thesurfaceofthetooth,andforthatmatter,theentirefieldofviewmustbecoatedwithathinopaquerlayer.Afinecoatoftitaniumdioxideproducesahighlyuniformscatteringofthelight.Theremainingvariationininten-sity is verydesirable since it enhances the three-dimensionalfeaturesofthepreparation.

Milling of the Ceramic Restoration Therestorationismilled(4-7minutes)withadiamondwheelfromapremanufacturedandstandardizedceramicblockinthemillingchamberoftheCAMunit.Factorystandardized,preformeddentalporcelainblocksarehomogenousandalmostpore-free(VitaCerecblocks,DicorCerecblocks).

The Cam UnitApumpsystemwithanattachedwaterreservoirlocatedatthebaseofthemobilecartmaintainsthewaterpressurerequiredfor thehydraulicdrivenwater turbine in themillingchamber.Duringmillingabout5litersofwateriscycledinternally,whicheliminatestheneedforexternalwatersupplyanddrainage.Thewater reservoirsystemalsocontainsamicroporousfilter thattrapsanyofthelooseneddiamondparticlesseparatedfromthewheelforfutureretrieval[27,28](Figure6).

Figure 6:Themillingunit.

Procedure[29,30]: •Theappropriateceramicblockisselectedfromase-riesconsistingofdifferentsizesandshade •Theceramicblockismountedonametalstub(retain-er), inserted into the milling unit and the grinding operation is initiated. •Grindingoftheceramicrestorationisdonebyadia-mond–coateddisk/wheelinconjunctionwithahighvelocitywater-spray,whichsimultaneouslycoolsandcleansthemillingdisk.Therestorationismilledfromthemesialtothedistalprox-imalsurfaceswiththeblockrotatingalongitscentralaxisandbeingsteadilyadvancedforwardduringthemillingprocess.Inaddition,thediamondwheelnotonlyrotatesbutalsotranslates

upanddownovertheporcelainblockbeingmilled.Aseriesofstepsorcuts(200–400)arerequiredformillingaceramicres-toration.

The Computer program associated with the milling process has additional interesting features such as[31]: • Before themilling process, the screen displays thedimensionsoftherestorationfromoneproximalsurfacetotheotherin1/900thofanmm. •Duringthemillingoperation,thescreencontinuouslyinformstheoperatorofthepercentageofcompletion. • A continuous readout is displayed concerning thecuttingefficiencyofthediamondwheel,therebyindicatingtheprobableneedforreplacement.

Advantages of CAD CAM[32-35]

1.Theconceptthatadentistcan,inasingleappointment,admin-isteranestheticinpreparationfor,preparethetoothfor,makeanimpression for, design, mill, customize and place a restoration isdesirableformanycliniciansandpatients.Thecommandof“one-appointment”dentistryispowerfulnotonlyforthepatient,butalsofortheentiredentalteamandtheoffice’sproductivity.Single-appointmentdentistryhasavarietyofbenefits:theneedforonlyoneadministrationofanesthetic,theabsenceofneedfortemporaryorprovisionalrestorations(therefore,nolosttempo-rariesorre-cementations),theabsenceoflaboratoryfeesandareductioninsecond-chairset-upcosts.Thesefactorsultimatelyequatetofewerinstrumentsneedingtobesterilized, lessneedforchairtimeset-up/breakdownandimprovedofficeefficiency. 2.Another, oftenoverlookedadvantage is thedisposable sup-plies that can be eliminated (from impression material, wax,stone, temporarybridge resin andcement to cottonandpaperdisposables)by institutionofaCAD/CAMsystem.Clinicianscangainotherintangibleadvantagesinthelongtermbyintro-ducing CAD/CAM technology into their already-busy dentalpractices.WithCAD/CAMtechnology,cliniciansmaintaintotalproduct and artistic control of the restorations to be fabricated and seated. It allows clinicians to spend themajority of theirtimeontoothpreparationandonseatingofthefinalrestoration;thesoftwareprograms’optionsdeliveraproductthatmayneedonlyendpointcharacterization,stainingorglazing.Thecomput-er and milling processes diminish potential inaccuracies result-ingfromthehand/laboratoryfabricationprocessandareabletoprovide a restoration that fitswithin the 50-micrometer rangeestablishedbytheAmericanDentalAssociation.

3.When thedentist implementsCAD/CAMtechnology,heorshe must create a schedule that supports single-appointment treatment.This schedule arrangement can both save time andincrease efficiency. Dentists can complete most CEREC sin-gle-unitcrownswithinoneandone-halfhours.Dentistscantreatquadrantswithintwoortwoandone-halfhours.Withthistypeofdentistry,thesecond“seating”appointmentnowisfreedupand can be re-designated for an additional productive appoint-ment.Givenatraditionaltwo-appointmentprocedureandtimeallotment, this single-appointment treatment approach becomes practical.Moreover, a practitioner seasoned in using CERECcanperformadditionalprocedureswhiletherestorationisbeingmilled,againenhancingthepractice’sefficiencyandproductiv-ity.

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4. Patients often experience irritation in, sensitivity in and/ordifficultyincleaningtemporizedteeth.Single-appointmentden-tistryavoidsthesecomplaints.Also,cliniciansmustconsiderthediminished chance of bacterial invasion during this phase; de-creasedpulpalstressresultingfromexcessivecleaning,dryingor trauma; and decreased need for the additional tooth manipu-lationthatoftenisexperiencedatasecondappointment.Giventhe fact that veneers represent a significant portion of labora-tory-fabricated restorations today and that veneer temporarieseasily can be displaced and are time-consuming to fabricate,dentistsshouldfindtheconvenienceofsingle-appointmentden-tistrysignificant.

5. Furthermore, theCEREC veneer software program is easytouseandwillenhance the implementationofsingle-appoint-ment dentistry.Dentists have the ability to include their teammembersbydelegatingsomeofthetasksintheCERECprocess.In sucha scenario, assistantsmaybe included in introductoryCERECtrainingandcanbettertheirskillsbytakingadditionaltrainingcoursesspecificallydesignedforassistants.Inpractice,the team approach flows thus: the dentist prepares the tooth,powdersitandmakestheopticalimpression.Thentheassistantdesigns the restoration, mills it, polishes it and prepares it for bonding.Finally,thedentistcompletestheprocedurebybond-ingtherestoration.

Disadvantages of CAD CAM[36-38]

Intheimplementationofanynewtechnology,discus-sions arise that require critical thinking. The primary consid-eration in a CAD/CAM purchase is the length of the learning curve,whichmayrangefromafewdaystoseveralmonthsandmay result in the lossofofficeproduction, the lossofpatienttreatmenttimeandanincreaseintheclinician’sfrustration.Oth-er obstacles to incorporating this system into practice are thecostof the equipment, thepotential for thedental team to re-sist the system’s use, the clinician’s lack of confidence in us-ingacomputerizedsystem,andperhapstheclinician’slackofwillingnesstolearnanewconceptthatwillrequiretrainingandpractice.Dentistswhohavedifficulty integrating this technol-ogyintotheirpracticesusuallyaredentistswhodonotwanttochangethewaytheyarepracticing. However,theadvantagesofthissystemoutweighthesedisadvantages listed and so it is emerging as a successful treat-mentoption.

Summary During the past decade, computer-aided design/ manu-facturing(CAD/CAM),whicharewell-knownprocessesintheindustrialworld,havefoundtheirwayintodentistry.Interestinthis designing and manufacturing process occurred because of itspotentialasanalternativetothelost-waxtechniquethathasbeenusedformanydecadesforfabricatingdentalrestorations.Anumber of reports in the literature[39-42]inrecentyearsdetailtheCAD/CAMmethods thathavebeenused indentistry.Equallyimpressive is the number of articles reporting on the clinical suc-cess and the improved characteristics of restorations fabricated bytheseCAD/CAMmethods.

References

1.Fairhurst,C.W.Dentalceramics:Thestateofthescience.(1992)AdvDentRes6:78-81.2.Giordano,R.,Cima,M., Pober,R.Effect of surface finish on theflexuralstrengthoffeldspathicandaluminousdentalceramic. (1995)IntJProsthodont8(4):311-319.3.Rinke,S.,Hüls,A.Copy-milledaluminouscoreceramiccrowns:Aclinicalreport.(1996)JProsthetDent76(4):343-346.4.Thompson,J.Y.,Bayne,S.C.,Heymann,H.O.Mechanicalpropertiesofanewmica-basedmachinableglassceramicforCAD/CAMresto-rations.(1996)JProsthetDent76(6):619-623.5.Heymann,H.O.,Bayne,S.C.,Sturdevant, J.R., et al. Theclinicalperformance of CAD-CAM-generated ceramic inlays: A four yearstudy.(1996)JAmDentAssoc127(8):1171-1181.6.Chai,J.,McGivney,G.P.,Munoz,C.A.,etal.Amulticenter longi-tudinalclinicaltrialofanewsystemforrestoration.(1997)JProsthetDent77(1):1-11.7.Odén,A.,Andersson,M.,Magnusson,D., et al.FiveyearclinicalevaluationofProceraAllCeramcrowns.(1998)JProsthetDent80(4):450-506.8.Willer, J.,Rossbach,A.,Weber,H.P.Computer-assistedmillingofdental restorations using a newCAD/CAM data acquisition system.(1998)JProsthetDent80(3):346-353.9.May,K.B.,Russell,M.M.,Razzoog,M.E.,etal.Precisionoffit:TheProceraAllCeramcrown.(1998)JProsthetDent80(4):394-404.10.Sellen,P.N.,Jagger,D.C.,Harrison,A.Computer-generatedstudyofthecorrelationbetweentooth,face,archforms,andpalatalcontour.(1998)JProsthetDent80(2):163-168.11.Sindel,J.,Frankenberger,R.,Krämer,N.,etal.CrackformationofAll-Ceramic crowns dependant on different core build-up and lutingmaterials.(1999)JDent27(3):175-181.12.Burke,F.J.Maximizingthefractureresistanceofdentine-bondedall-ceramiccrowns.(1999)JDent27(3):169-173.13.Chen,H.Y.,Hickel,R.,Setcos, J.C., et al.Effectsof surfacefin-ish and fatigue testing on the fracture strength of CAD-CAM and pressed-ceramiccrowns.(1999)JProsthetDent82(4):468-475.14.Olthoff,L.W.,VanderZel, J.M.,DeRuiter,W.J.,etal.Comput-ermodelingofocclusalsurfacesofposterior teethwith theCICEROCAD/CAMsystem.(2000)JProsthetDent84(2):154-162.15.Dahlmo,K.I.,Andersson,M.,Gellerstedt,M.,etal.Onanewmeth-odtoassesstheaccuracyofaCADprogram.(2001)IntJProsthodont14(3):276-283.16.Antonson, S.A.,Anusavice,K.J. Contrast ratio of veneering andcoreceramicsasafunctionofthickness.(2001)IntJProsthodont14(4):316-320.17.Yoshida,K.,Kamada,K.,Atsuta,M.Effectsoftwosilanecouplingagents,abondingagent,andthermalcyclingonthebondstrengthofaCAD/CAMcompositematerialcementedwithtworesinlutingagents.(2001)JProsthetDent85(2):184-189.18.Marchack,C.B.,Yamashita,T.Fabricationofadigitallyscanned,custom-shaped abutment: A clinical report. (2001) J Prosthet Dent85(2):113-115.19.VanderZel,J.M.,Vlaar,S.,DeRuiter,W.J.,etal.TheCICEROsystem for CAD/CAM fabrication of full-ceramic crowns. (2001) JProsthetDent85(3):261-267.20.Bindl,A.,Mörmann,W.H.An upto 5-year clinical evaluation ofposterior in-ceramCAD/CAMcorecrowns. (2002)IntJProsthodont15(5):451-456.21.Otto,T.,DeNisco,S.Computer-aideddirectceramicrestorations:10-yearprospectiveclinicalstudyofcerecCAD/CAMinlaysandon-lays.(2002)IntJProsthodont15(2):122-128.22.Runte,C.,Dirksen,D.,Deleré,H.,etal.Opticaldataacquisitionforcomputer-assisteddesignoffacialprosthesis.(2002)IntJProsthodont15(2):129-132.23.Addi,S.,Hedayati-Khams,A.,Poya,A., et al. Interfacegap sizeofmanually andCAD/CAM-manufactured ceramic inlays/onlays in

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