june 1, 2011 senology.org newsletter

Senology.org - Newsletter

International Senologic and Oncologic Scientific Community

"Connecting specialists worldwide"

Editor-in-chief: Gian Paolo Andreoletti, MD

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Literature Selection

Li J et al.: "Coffee consumption modifies risk of estrogen-receptor negative breast cancer", Breast

Cancer Res. 2011 May 14;13(3):R49. [Epub ahead of print]

Elkin EB et al.: "Characteristics and Outcomes of Breast Cancer in Women With and Without a

History of Radiation for Hodgkin's Lymphoma: A Multi-Institutional, Matched Cohort Study", J Clin

Oncol. 2011 May 16. [Epub ahead of print]

Kirsh VA et al.: "Tumor Characteristics Associated With Mammographic Detection of Breast Cancer

in the Ontario Breast Screening Program", J Natl Cancer Inst. 2011 May 3. [Epub ahead of print]

Ohsumi S et al.: "Detection of isolated ipsilateral regional lymph node recurrences by

F18-fluorodeoxyglucose positron emission tomography-CT in follow-up of postoperative breast

cancer patients"

Freedman AN et al.: "Benefit/Risk Assessment for Breast Cancer Chemoprevention With Raloxifene

or Tamoxifen for Women Age 50 Years or Older", J Clin Oncol. 2011 May 2. [Epub ahead of print]

Hatzis C et al.: "A genomic predictor of response and survival following taxane-anthracycline

chemotherapy for invasive breast cancer", JAMA. 2011 May 11;305(18):1873-81

Pfeiler G et al.: "Impact of Body Mass Index on the Efficacy of Endocrine Therapy in Premenopausal

Patients With Breast Cancer: An Analysis of the Prospective ABCSG-12 Trial", J Clin Oncol. 2011

May 9. [Epub ahead of print]

Nedumpara T et al.: "Impact of immediate breast reconstruction on breast cancer recurrence and

survival", Breast. 2011 May 19. [Epub ahead of print]

Petit JY et al.: "Locoregional recurrence risk after lipofilling in breast cancer patients", Ann Oncol.

2011 May 24. [Epub ahead of print]

Arver B et al.: "Bilateral Prophylactic Mastectomy in Swedish Women at High Risk of Breast Cancer:

A National Survey", Ann Surg. 2011 Jun;253(6):1147-1154

Senology Newsletter http://www.senology.org/newsletter/Newsl_Jun2011.htm

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Ono M et al.: "Tumor-infiltrating lymphocytes are correlated with response to neoadjuvant

chemotherapy in triple-negative breast cancer", Breast Cancer Res Treat. 2011 May 12. [Epub ahead

of print]

Comment

"The 21-gene assay in early-stage breast cancer" - David B. Geffen, Department of Oncology, Soroka

University Medical Center and the Faculty of Health Sciences, Ben Gurion University of the Negev. Beer

Sheva, Israel

"The prognosis of early stage estrogen receptor positive breast cancer is generally very good and the

average benefit of adding adjuvant chemotherapy to adjuvant endocrine therapy is small but exists. The

21-gene recurrence score (RS) assay has been validated through the use of retrospective studies as

prognostic of distant disease recurrence and predictive of the benefit of adding chemotherapy. We evaluated

the impact of using the test in our practice, a university based group of oncologists who have a uniform

treatment policy. For a high risk RS, chemotherapy was recommended, for a low risk, endocrine therapy

alone and for intermediate risk, treatment based on traditional clinicopathologic factors with help from

Adjuvant!on-line. In this retrospective analysis of 135 patients whom we tested with the 21-gene RS between

2006- 2009, in 25 % of patients we changed recommendation after obtaining results. Most changes were in

the direction of not giving chemotherapy (70% of changes). A somewhat surprising finding was that 29 % of

the 49 patients for whom we recommended chemotherapy after obtaining the RS, refused chemotherapy. The

RS substantially reduced the number of patients receiving chemotherapy but we need to improve our

patients' understanding of the implications of the test"

(Comment on: Geffen DB et al.: "The impact of the 21-gene recurrence score assay on decision

making about adjuvant chemotherapy in early-stage estrogen-receptor-positive breast cancer in an

oncology practice with a unified treatment policy", Ann Oncol. 2011 Mar 1. [Epub ahead of print])

Healthcare Companies News

Genomic Health announces positive preliminary results of Oncotype DX® study in DCIS breast

cancer

Share your opinions and comments on LinkedIn®

Fragments of History

Charles H. Moore:, Royal Medical and Chirugical Society, London, 1867: “On the influence of inadequate

operations on the theory of cancer", Med Chir Trans, 1867, 32: 245-80: “Taught without doubt by

foregoing failures, our surgical ancestors adopted a method of operating which might well have been

expected to prove effectual against a local recurrence of the disease. They transfixed the base of the

mamma, and, raising it with ligatures, swept off the whole organ, together with all the skin that covered it.

The proceeding had a barbarous appearance enough, but it was promising; and, if their knowledge of the

disease had led the Surgeons of the time to adopt it before the skin was hopelessly infiltrated, they must

have met with more success than they appear to have done. Postponing, however, all operation until the skin

was brawny and covered with tubercles, and the deeper textures were involved without limit, they failed too

often, with even such extensive cutting as they adopted, to comprehend the entire disease. It was a mistaken

kindness which led to a change of this mode of operating. Under the influence of a clergyman, who

expressed what must have been a prevailing horror at such Amazonian surgery, the practice was changed to

an incision in the integument, which was reflected in flaps and brought together again after the removal of

the cancerous tumour. There could have been no diminution of suffering by this prolongation of the

operation, and what was gained by it in neatness was lost in life."

Calendar of Events

6th World Conference on Breast Cancer, June 7 -11, 2011, Hamilton, Ontario, Canada

13th Milan Breast Cancer Conference, June 22-24, 2011, Milan Italy

1st International Michelangelo Conference, June 30 - July 1, Milan, Italy

Breast Cancer Symposium 2011, September 8-10, 2011, San Francisco, California

7th Meet the Professor. Modena International Breast Cancer Conference (MIBCC)

October 5-7, 2011, Modena, Italy

1st Advanced Breast Cancer International Consensus Conference, November 3-5, 2011, Lisbon,

Portugal

AORTIC (African Organisation for Research and Training in Cancer) - 8th International Conference,


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November 28 - December 2, 2011, Cairo, Egypt


Hu J et al.: "Dietary cholesterol intake and cancer", Ann Oncol. 2011 May 4. [Epub ahead of print]

Nagle CM et al.: "Reducing Time to Diagnosis Does Not Improve Outcomes for Women With

Symptomatic Ovarian Cancer: A Report From the Australian Ovarian Cancer Study Group", J Clin

Oncol. 2011 May 2. [Epub ahead of print]

Syrjala KL et al.: "Prospective Neurocognitive Function Over 5 Years After Allogeneic

Hematopoietic Cell Transplantation for Cancer Survivors Compared With Matched Controls at 5

Years", J Clin Oncol. 2011 May 2. [Epub ahead of print]

Zhu H et al.: "Thoracic radiation therapy improves the overall survival of patients with

extensive-stage small cell lung cancer with distant metastasis", Cancer. 2011 May 11. doi:

10.1002/cncr.26206. [Epub ahead of print]

Schenk JM et al.: "Association of Symptomatic Benign Prostatic Hyperplasia and Prostate Cancer:

Results from the Prostate Cancer Prevention Trial", Am J Epidemiol. 2011 May 3. [Epub ahead of

print]

Bill-Axelson A et al.: "Radical prostatectomy versus watchful waiting in early prostate cancer", N

Engl J Med. 2011 May 5;364(18):1708-17

Jacobs EJ et al.: "A Large Cohort Study of Long-term Acetaminophen Use and Prostate Cancer

Incidence", Cancer Epidemiol Biomarkers Prev. 2011 May 17. [Epub ahead of print]

Richman EL et al.: "Physical Activity after Diagnosis and Risk of Prostate Cancer Progression: Data

from the Cancer of the Prostate Strategic Urologic Research Endeavor", Cancer Res. 2011 May 24.

[Epub ahead of print]

Wilson KM et al.: "Coffee Consumption and Prostate Cancer Risk and Progression in the Health

Professionals Follow-up Study", J Natl Cancer Inst. 2011 May 17. [Epub ahead of print]


Altman D et al.: "Anterior colporrhaphy versus transvaginal mesh for pelvic-organ prolapse", N Engl

J Med. 2011 May 12;364(19):1826-36

Stay informed....

Recent Advances in Clinical Medicine

Kajstura J et al.: "Evidence for human lung stem cells", N Engl J Med. 2011 May 12;364(19):1795-806

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