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8/20/2019 JURNAL LAIL KULIT

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Journal Reading“Roles of Adapalene in theTreatment of Pityriasis Versicolor”

Professional Mentor: dr. Bo o !ahyudi" #p.$$ By:%ur &arda 'a(atulail

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#TA#/ $012T &A% $/1AM2%R#0& $3TA BA%JAR

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IntroductionP2T5R2A#2#

V/R#26313RFungal Infection of the skin caused by Malassezia yeast

-

-Discrete orconcrescent-slightlyscaling

macules-

Hypopigmented or

hyperpigmented area

-mainly on theupper trunk

and neck

-clinicalsymptoms

-directmicroscopy

Including:- Zinc

prrithione- Selenium

Sul de- !ntifungalagents

- Retinoicacid cream

Characters Diagnosis "herapies

!dapalenegel:

! tretinoinderi#ati#e

and a

selectionretinoic acidanalogue

Ho$e#er% there are no reports on adapelene for the tratments ofpityriasis #ersicolor


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Sub&ects and Methods

6linical Trial

! prospecti#eDouble blind

'andomi(ed controlled

studyMain aim

"o compare e)cacy ofadopalene $ith * + of

ketocona(ole cream inthe treatment of

pytiriasis #ersicolor


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!llpatients

Han people $ith pytiriasis#ersicolor

clinical symptoms, .He/amination

/7clusion 6riteria:Patients :-$ho had recei#ed systemic0topical antimycotic at least 1month prior to the study-$ith serious diseases or other fungal infections-$ith pregnant or nursing mothers-$ith history of allergic to ketocona(ole or adapalene-$ho interupted the treatment


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2roup.ne

!dapalene

gel t$icedaily for t$o$eeks

2roup "$o

*+ketocona(olecream t$icedaily for t$o

$eeks

3ligble4atients

During the

studyperiod% theuse ofanotherdrugs $as


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Sub&ects and Methods5Statistics and Analysis)

"o compare se/%age% duration% and

lession a6ected areabet$een t$o group

"o compare theimpro#ement ratefor each treatment

group

Student7s and Mann-8hitney u test

"he / 9 test p #alues ;%;< $ere

considered assigni cant results


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'esults


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'esults


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'esults


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Discussion

"reatment $ithoral ketocona(ole$as e6ecti#e for

4ytiriasis=ersicolor

Many patients$orry about the

side e6ects

4refer topicaltherapy Fre>uent use

4ossibly promotesthe drugs

resistence offungi

Thus" e try notonly clearinfections fungi"

8ut also a9oiddrug resistence


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Discussion

Tretinoin cream $as e6ecti#e for

treatment of pytiriasis#ersicolor adapalene gel is tretinoinderi9itati9e


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Discussion

•

'o can e account for the e cacyof adapalene in the tratment ofpytiriasis 9ersicolor;

!dapalene

1? Strip abnormalkeratynocytes

*? @ormali(e the dysfunction

A? Dicrease the sebumsecretion

"hus

!dapalene gel promotes anen#ironment in hospitable toMalasse(ia yeasts eliminated together iththe a8normal cell layer


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Conclussion

•

In this study $e found that adapalene gel$as not inferior to *+ ketocona(olecream in the treatment of pityriasis#ersicolor?

• !dapalene is a fa#orable option in thetreatment of pityriasis #ersicolor


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'eferences


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"H!@ B.

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