8/13/2019 K.27b Infeksi Virus

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INFEKSI VIRUS PADA

REPRODUCTIVE SYSTEM

Dr.Gerben F. Hutabarat DTM&H, MSc, SpMK

8/13/2019 K.27b Infeksi Virus

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I. DNA VIRUS

1. HERPES SIMPLEX VIRUS (HSV)

2. CYTOMEGALO VIRUS (CMV)3. PAPILOMA VIRUS (HPV)

4. PARVO VIRUS (B19 virus) (Big19 V)

5. Hepatitis B. Virus (HBV)

II. RNA Virus

1. RUBI VIRUS ( RUBELLA VIRUS)2. HUMAN IMMUNO DEFICIENCY V. (HIV)

3. MEASLES VIRUS.

4. MUMPS VIRUS.

8/13/2019 K.27b Infeksi Virus

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Virus Penyakit Sifat Virus Cara

penularan

Gejala Diagnosa

Lab

Preventian

Herpes

Simplex

Virus2

(HSV)

- Gemital

Herpes.

- Neonatal

Herpes

- DNA

- double

stranded

- 100m

Sexual

Intercourse

-Vesicular

eruption

-Jaundice

-Hepato

splenomegal

i-Therombo

cytopenia

-Vesicular

skin

-Isolasi

-Vesicle fluid

-Skin swab

Inoculate

-Tissue

culture

(BHK21)

HELC

-Serolgy

8/13/2019 K.27b Infeksi Virus

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Virus Penyakit Sifat Virus Cara

penularan

Gejala Diagnosa

Lab

Preventian

Papiloma Virus

(HumanPapiloma Virus

= HPV)

-Genital wartz

(condylomaacuminata)

-DNA

- Doublestranded

circular DNA

-50 nm

Sexual

intercourse

- Marked

froliferation ofepithelial cell

(Condyloma

acuminata)

- Kilocytes in

the lesion- Serology

No Vaccine

8/13/2019 K.27b Infeksi Virus

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Virus Penyakit Sifat Virus Cara

penularan

Gejala Diagnosa

Lab

Preventian

Hepatitis B.V.

(HBV)

Hepatitis B.

(acut HepatitisB).

Incubation

Period :

1012 weeks

Chronic

Carriers

Hepato cellular

carcinoma

- DNA 22 nm

- 42 nm asDane

particles

- Sexual

intercourse- Transplacent

ally

transmission.

- Or during

delivery.

-Jaundice -Ibu Serology

HBs Ag dgn-RIA

-EIA

-RPA

-CIE

= Vaccin

Recombivax= Hyper

immune

globulin :

- Hepatitis B

Immune

globulin

(HBIG)

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Virus Penyakit Sifat Virus Cara

penularan

Gejala Diagnosa

Lab

Preventian

Rubella Virus

(Rubi Virus)

HIV

Rubella

(Germanmeasles) in

pregnancy.

Incubation

periode 14

21 days

AIDS

RNA

50

75 m

Rna

- Respiratory

droplot-Transplacantal

ly

-Sexual-contact

-Transferof

infected blood

-Transplacen

tally

-Congenital

defect (Triad :cataraet, nerve

defnes, cordiac

abnormality)

The Rubella

Syndrome

-Serology HI

testi Ig : risingteter

-Ig M (CFT,

RIH)

-Serology Elisa: Ab

-Western blot

-Vaccein

1. dose s. e(Live

attenunated

Virus Vaccin.

Novaccine is

available

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Virus Penyakit Sifat Virus Cara

penularan

Gejala Diagnosa

Lab

Preventian

Measles Measles =

Rubeola =

Morbili

Life long

Immunity

Incubation

Periode : 10

14 days

-RNA

-120-250 nm-0ne

serological

type

Inkalation

Respiratorysecretion

- Fatal death

- Gejal pd ibu

-Fever

-Conjunetivitis

-Running nose

- coughing

- Kopling spots

in buccal

- Isolation in

cell culture

- Serology

rising

titugreater

than 4 fold

Measles

VaccineOne dose s.e

Life

attenuated

vaccine

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Virus Penyakit Sifat Virus Cara

penularan

Gejala Diagnosa

Lab

Preventian

Mump V. Mumps

Parotitis

epidemica

Life long

Immunity

Maternal

antibodypasses the

placenta

immunity frist

6 month of

life. Incubation

period 1821

days

-RNA

-

110

170 nm-Envelope

particles

- Droplet

infection

-Fever malaise

anomxia.

- Tender

swalling parotid

gland

- Serology

CFT use :

SAg

(Saluble

Ag)

- V Ag (Viral

Ag)

- Culture

Saliva,

spinal fluid,urine.

Mumps

Vaccine

Life attenuated

vaccine

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Virus Penyakit Sifat Virus Cara

penularan

Gejala Diagnosa

Lab

Preventian

Cytomegalo

Virus (CMV)

Cytomegalic

InclusionDisease (CID)

-DNA -Sexual

intercouse,blood

transfusion

-

Transplacentall

y in utero

-Fetus

-mentalretardation

-Jaundice

-Hep-

splermegali

-Blood discrasis

(thrombocyto

penia)Haemolytie

anemia

-Microcephali

-Motor diseases

-Isolasi urine

-throat swab-Inoculasi

HELC

CPE Swallen

cell

-Serologi

CFT, IF

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Virus Penyakit Sifat Virus Cara

penularan

Gejala Diagnosa

Lab

Preventian

Parvovirus

B19

-

Slappetdtcheeks syndrome,

-Fifth disease

-Aplastic

anemia

-Fetal

infections

-DNA

-Singlestranded

genome

-Respiratory

route-Blood

transfusions

-Transplacental

transmission

(Infection frist

trisemester)

-Fetal death -Detecting

IgM-Isolation

from throat

swabs

-PCR Dna for

blood

amniotic fluid