karen nunley presentation
DESCRIPTION
2nd Annual DCC RetreatTRANSCRIPT
BIOMONITORING:BIOMONITORING:A PLAN FOR DELAWAREA PLAN FOR DELAWARE
DELAWARE CANCER CONSORTIUM RETREAT DELAWARE CANCER CONSORTIUM RETREAT
FEBRUARY 15, 2010FEBRUARY 15, 2010
Karen Nunley, M.S.
MULTI-MEDIA EXPOSURE STUDYMULTI-MEDIA EXPOSURE STUDY
IntroductionIntroduction BiomonitoringBiomonitoring
BenefitsBenefits LimitationsLimitations
Delaware’s PlanDelaware’s Plan Discussion / Q & ADiscussion / Q & A
MULTI-MEDIA EXPOSUREMULTI-MEDIA EXPOSURE
MULTI-MEDIA EXPOSUREMULTI-MEDIA EXPOSURE
CHEMICALS ENTER THE BODY CHEMICALS ENTER THE BODY VIA:VIA:
Dermal AbsorptionDermal Absorption
InhalationInhalation
IngestionIngestion
InjectionInjection
MULTI-MEDIA EXPOSUREMULTI-MEDIA EXPOSURE
WHAT IS BIOMONITORING?WHAT IS BIOMONITORING?
Measuring human tissue and bodily fluids Measuring human tissue and bodily fluids for the presence of chemicals or their for the presence of chemicals or their metabolitesmetabolites
WHAT IS BIOMONITORING?WHAT IS BIOMONITORING?
Measuring human tissue and bodily fluids Measuring human tissue and bodily fluids for the presence of chemicals or their for the presence of chemicals or their metabolitesmetabolites
Provides information about the ‘internal’ Provides information about the ‘internal’ dose rather than the ‘external’ dose rather than the ‘external’
concentrationconcentration
EFFECTS DEPEND ON:EFFECTS DEPEND ON:
Exposure routeExposure route
Exposure durationExposure duration
Exposure frequencyExposure frequency
Exposure intensityExposure intensity
HISTORYHISTORY
Used in late 1800s to test workers for Used in late 1800s to test workers for
lead and to monitor salicyluric acid lead and to monitor salicyluric acid levels in people being treated for levels in people being treated for rheumatismrheumatism
Historically used in occupational Historically used in occupational settingssettings
HISTORYHISTORY
In the last few decades, expanded In the last few decades, expanded to measure chemical exposures in to measure chemical exposures in the general populationthe general population
BIOMARKERSBIOMARKERS
ExposureExposure
EffectEffect
SusceptibilitySusceptibility
All substances are poisons; there is none which All substances are poisons; there is none which is not a poison. The right dose differentiates a is not a poison. The right dose differentiates a poison from a remedy (poison from a remedy (Paracelsus, 1567)Paracelsus, 1567)
BENEFITSBENEFITS
LIMITATIONSLIMITATIONS
Only a snapshot of exposureOnly a snapshot of exposure
Exposure Exposure Disease Disease
Cannot reveal exposure sources or Cannot reveal exposure sources or routes routes
Influence of personal behaviors, Influence of personal behaviors, geneticsgenetics
Unknown additive/synergistic effects of Unknown additive/synergistic effects of chemicals chemicals
Ethical issuesEthical issues
DELAWARE’S BIOMONITORING DELAWARE’S BIOMONITORING PLANPLAN
DELAWARE’S BIOMONITORING DELAWARE’S BIOMONITORING PLANPLAN
Pilot three target areasPilot three target areas
Approximately 400 Delawareans ages18 and Approximately 400 Delawareans ages18 and olderolder
Samples collected summer and winter; Samples collected summer and winter; repeat over 2-3 yearsrepeat over 2-3 years
Expand to statewide samplingExpand to statewide sampling
DELAWARE’S BIOMONITORING DELAWARE’S BIOMONITORING PLANPLAN
Testing for variety of substancesTesting for variety of substances Blood, urine, hair samplesBlood, urine, hair samples
Extensive questionnaireExtensive questionnaire
Environmental SamplesEnvironmental Samples Water, air, soil/dustWater, air, soil/dust
DELAWARE’S BIOMONITORING DELAWARE’S BIOMONITORING PLANPLAN
Prospective Study Prospective Study
Archive samples for future testingArchive samples for future testing
Create databaseCreate database
DATABASE FUNCTIONS:DATABASE FUNCTIONS:
Detect which chemicals are present in Detect which chemicals are present in Delawareans, and in what Delawareans, and in what concentrationsconcentrations
Regional exposure varianceRegional exposure variance
Exposure disparitiesExposure disparities
Monitor changes over timeMonitor changes over time
Evaluate Public Health programsEvaluate Public Health programs
FUTURE USES:FUTURE USES:
Enact and evaluate effectiveness of Enact and evaluate effectiveness of exposure reduction strategiesexposure reduction strategies
Support legislationSupport legislation
Provide data to support future Provide data to support future epidemiological studies via linkage to epidemiological studies via linkage to disease and hospitalization recordsdisease and hospitalization records
Decrease uncertainty inherent in Decrease uncertainty inherent in exposure risk assessmentsexposure risk assessments
WILL NOT:WILL NOT:
Sample every DelawareanSample every Delawarean
Provide full exposure history Provide full exposure history
Identify exact exposure source(s) or Identify exact exposure source(s) or disease causationdisease causation
Identify who will or will not develop a Identify who will or will not develop a disease endpointdisease endpoint
Q & AQ & A
THANK YOU!THANK YOU!
Karen Nunley, M.S.