Safe and effective Aspirin regimen

Indication for Use Anti-platelet Pain Fever Anti-inflammatory

Effective Dose Minimum dose with maximum effect is 75 mg daily

Randomized Control Trial

Level of Evidence 2

Second loading dose effective in AMI’s

Gurbel et al., 2007

Fuchs et al., 2010

Things that affect Efficacy

Ranitidine Effect of ranitidine on the antiplatelet effects of aspirin in

healthy human subjects.

Level 2

Randomized control study

Lev et al., 2007

Thing That Affect Efficacy

Things That affect efficacy

Enteric Coating Effect of enteric coating on antiplatelet activity of low-dose

aspirin in healthy volunteers.

Level 2

Randomized Control Trial

Cox et al., 2006

Contraindications

Asthma

GI-Bleeding

Allergy

References Cox, D., Maree, A., Dooley, M., Conroy, R., Byrne, M., & Fitzgerald, D. (2006).

Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers. Stroke (00392499), 37(8), 2153-2158.

Fuchs, I., Spiel, A., Frossard, M., Derhaschnig, U., Riedmüller, E., & Jilma, B. (2010). Platelet hyperfunction is decreased by additional aspirin loading in patients presenting with myocardial infarction on daily aspirin therapy. Critical Care Medicine, 38(6), 1423-1429. doi:10.1097/CCM.0b013e3181de8b1e

Gurbel, P., Bliden, K., DiChiara, J., Newcomer, J., Weng, W., Neerchal, N., & ... Tantry, U. (2007). Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study. Circulation, 115(25), 3156-3164.

Lev, E., Ramabadran, R., Guthikonda, S., Patel, R., Kleiman, A., Granada, J., & ... Kleiman, N. (2007). Effect of ranitidine on the antiplatelet effects of aspirin in healthy human subjects. American Journal Of

Cardiology, 99(1), 124-128.

Würtz, M., Grove, E., Kristensen, S., & Hvas, A. (2010). The antiplatelet effect of aspirin is reduced by proton pump inhibitors in patients with coronary artery disease. Heart, 96(5), 368-371. doi:10.1136/hrt.2009.181107