kaushik p. p - university of nebraska medical center · 2020-04-03 · 2017 patel, kaushik p. 2...

2017 PATEL, KAUSHIK P.

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KAUSHIK P. PATEL

CURRICULUM VITAE

HOME ADDRESS 1328 North 161 Street Omaha, NE. 68118 Phone: (402) 493-4430 CAMPUS ADDRESS Department of Cellular and Integrative Physiology University of Nebraska Medical Center 984575 Nebraska Medical Center Omaha, NE. 68198-5850 Phone: (402) 559-8369 Fax: (402) 559-4438 Email: [email protected] PLACE OF BIRTH Kampala, Uganda

EDUCATION Sept 1974 to May 1978 University of Toronto, Toronto, Ontario, Canada B.Sc. in Physiology & Pharmacology, 1978 (Honors) Sept 1978 to May 1980 University of Western Ontario, London, Ontario, Canada M.Sc. in Physiology, 1980 (Advisor: Robert L. Kline, Ph.D.)

Dissertation: Noradrenergic mechanisms in brain and peripheral organs of normotensive and spontaneously hypertensive rats (SHR) at various ages

May 1980 to July 1983 University of Western Ontario, London, Ontario, Canada Ph.D. in Physiology, 1983 (Advisor: Robert L. Kline, Ph.D.)

Dissertation: Hypothalamic and peripheral noradrenergic responses to changes in baroreceptor input in conscious rats with and without renal nerves

POSTDOCTORAL TRAINING Jan 1984 to April 1987 Postdoctoral Fellow (Advisor: Philip G. Schmid, M.D) Cardiovascular Research Center, University of Iowa, Iowa City, IA July 1983 to Dec 1983 Research Associate (Advisor: Robert L. Kline, Ph.D) University of Western Ontario, London, Ontario, Canada.


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ACADEMIC APPOINTMENTS 2013 - Present Endowed Professorship; A. Ross McIntyre Professor of Physiology 2011 - 2011 Vice-Chair for Research in the Department of Cellular and Integrative

Physiology, University of Nebraska Medical Center, Omaha, NE 1998 - Present Professor, Department of Cellular and Integrative Physiology University of Nebraska Medical Center, Omaha, NE 1993 - Present Continuous Appointment (Tenure) Department of Cellular and Integrative Physiology University of Nebraska Medical Center, Omaha, NE 1991 - 1998 Associate Professor, Department of Physiology & Biophysics University of Nebraska Medical Center, Omaha, NE 1991 Continuous Appointment (Tenure), Department of Physiology &

Pharmacology, USD School of Medicine, University of South Dakota, Vermillion, SD

1990 - 1991 Associate Professor, Department of Physiology & Pharmacology, USD School of Medicine, University of South Dakota, Vermillion, SD

1987 - 1990 Assistant Professor, Department of Physiology & Pharmacology, USD School of Medicine, University of South Dakota, Vermillion, SD

1984 - 1987 Postdoctoral Fellow, Cardiovascular Research Center, Department of Internal Medicine, University of Iowa, Iowa City, IA

1983 - 1984 Research Associate, University of Western Ontario, London, Ontario, Canada

1978 - 1983 Laboratory Instructor, University of Western Ontario, London, Ontario, Canada

OTHER APPOINTMENTS OR POSITIONS Special Graduate Faculty status at Kansas State University, Manhattan, Kansas 1995 - 1998 Special Graduate Faculty status at Creighton, University, Omaha, Nebraska 2001 - 2006

GRANT/CONTRACT SUPPORT Current Grant Support - 1. 5 P01 HL062222-15 Project 2 (Patel) 07/01/15-06/30/20

National Institutes of Health; NIH - PPG grant. Project II: Activation of the PVN in heart failure: Role of HIF1-alpha and renal afferents K.P. PATEL, Principal Investigator. (35% effort) Total direct amount of award: $1,233,271; first year: $282,561 Period of support: 07/01/15 to 06/30/20

2. 1R01 DK114663-01 (Patel) 08/15/17-06/30/22 National Institutes of Health; NIH - RO1 grant -

Sodium Retention in Chronic Heart Failure: Novel Mechanisms and Therapies


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K.P. PATEL, PI (35% effort), Total direct amount of award: $1,361,200; first year: $272,240. Period of support: 08/15/17 to 06/30/22

3. 5 P01 HL062222-15 Project 3 (Schultz) 07/01/15-06/30/20

National Institutes of Health; NIH - PPG grant. Project II: Carotid Body in Pathophysiology of Heart Failure: Afferent-Efferent Mechanisms

K.P. PATEL, Co-Investigator Investigator. (5% effort) Total direct amount of award: $1,233,271; Period of support: 07/01/15 to 06/30/20

4. 5R01HL113281-03 (Mishra) 09/01/13 - 7/31/18 DHHS/NIH/NHLBI Inflammation, MiRNA and autophage in diabetes The goal of this grant is to understand the role of miRNA in regulation of inflammation and autophagy in diabetic hearts. Role: Co-Investigator

5. 1R01HL116205-02 (Mishra) 09/01/13 - 06/30/18 DHHS/NIH/NHLBI Exercise and H2S mitigate homocysteine-mediated beta2-adrenergic receptor dysfunction The goal of this grant is to determine the role of exercise and H2S in ameliorating the cardiac dysfunction by improving beta2-adrenergic receptor response and down regulating homocysteine in diabetes. Role: Co-Investigator

6. NCCS Pilot Project (Sorgen, Paul) 08/15/16-08/14/18

DHHS/NIH/NHLBI Regulation of Connexin43 by Pyk2 in Cardiac Hypertrophy The goals of Project are to determine the Define the biological significance of Cx43 Y313 phosphorylation by Pyk2 and determine if Cx43 function is altered by Pyk2 phosphorylation in cardiac hypertrophy. Role: Co-Investigator (1% effort)

Previous Grant Support – (Terminated within the last three years) 1. 5 R01 DK082956-04 Patel (PI) 03/01/09-02/28/14 DHHS/NIH/NIDDK Exercise Training Improves Erectile Dysfunction in Diabetes: Role of Central Mechanisms The proposed study will provide new information regarding the central mechanisms involved in altered neural regulation of erectile function and therapeutic benefits of exercise training on erectile dysfunction in diabetes. Role: Principle Investigator


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2. 5 P01 HL062222-14 Project 2 (Patel) 07/01/09-06/30/15 DHHS/NIH/NHLBI Neuro-Circulatory Function in Chronic Heart Failure Project II Title: The role of excitatory input into the PVN on increased sympathetic drive in heart failure. The goals of Project II are to determine the source of activation of the PVN responsible for increased sympathetic activity in heart failure. Role: PI of Project II 3. 1R56HL124104-01 (Patel) 09/01/14-08/31/15 DHHS/NIH/NHLBI Role of HIF1-alpha and Renal Afferents in Activation of the PVN in Heart Failure Understanding the role of central mechanisms and the therapeutic value of renal denervation and exercise training will enhance our ability to treat the heart failure condition and its systemic complications. Role: Principal Investigator Pending Grant Support –

1. National Institutes of Health; NIH - RO1 grant -

Novel way to improve erectile dysfunction in diabetes: Role for renal nerves K.P. PATEL, Co-PI (25% effort), PI: Hong Zheng Total direct amount of award: $1,250,000; first year: $250,000. Period of support: /01/17 to 03/31/22 (under review)

Student/Post-doc/Junior Faculty; Fellowship/Grants 1. Kenichi Katsurada, Post-doctoral Fellowship, Japan, 2017 - 2018 Total direct amount of award: $30,000 2. Neeru Sharma, Instructor Scientist Development Grant, American Heart Association, 2014 - 2018 Total direct amount of award: $250,000


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CONSULTING POSITIONS Study Sections, Regular Member - 1988 Ad Hoc Reviewer, VA Merit Review 1989 - 1993 American Heart Association, Great Plains Regional Research Review Committee 1992 American Heart Association, Co-Chairman, Great Plains Regional Research Review Committee 1993 American Heart Association, Chairman, Great Plains Regional Research Review Committee 1994 American Heart Association, Western Regional Review Committee 1995 - 1998 American Heart Association, (National Affiliates) “Control of Circulation” - Study Section 1995 - present Ad Hoc Reviewer, VA Merit Review 1995 - present Member of NIH Reviewer’s Reserve 1997 American Heart Association, (National) Scholar Student Program - Basic Science Study Section 1997 - present Scientific Advisory Board, International Academy of Cardiology 1999 - 2002 American Heart Association, (National Affiliates) “Renal & Cardiovascular” - Study Section 1999 National Institutes of Health (NHLBI) Ischemic Heart Disease SCORE - Science Study Section 2000 National Institutes of Health (NHLBI) Neurological disorders in Diabetes - Science Study Section 2000 National Institutes of Health (NHLBI) Programs of Excellence in Gene Therapy (Special Emphasis panel) 2005 Reviewer: National Institutes of Health - NHLBI - CICS Study Section (2005 - March) 2005 Reviewer: National Institutes of Health - NHLBI - CICS Study Section (2005 - July) 2005 Reviewer: National Institutes of Health - NHLBI – Hypertension & Microcirculation Study Section (2005 - Oct) 2005 Irish Medical Research Council -2005 2004 - 2005 Australian Heart Foundation Grant reviewer 2004 - 2005 Welcome Trust – Grant reviewer 2006 Reviewer: National Institutes of Health - NHLBI – ZRG1 RUS E11 Study Section (2006 - February) 2006 Reviewer: National Institutes of Health - NHLBI – PPG Study Section (2006 - September) 2007 Reviewer: Medical Research Council of Britain (MRC) (March - April

2007) 2007-08 Reviewer: National Institutes of Health

NHLBI – Hypertension & Microcirculation Study Section (Oct 07 – Feb 08) 2008 Reviewer: Department of Defense (DOD) DOD - Pulmonary Hypertension Study Section (Sept 08) 2009 Reviewer: National Institutes of Health

NHLBI –Hypertension & Microcirculation Study Section-special panel (Jun 09) another special panel (July 09)


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2009 Irish Medical Research Council - 2009 2009 Reviewer: Medical Research Council of Britain (MRC) (Nov 2009) 2009 Welcome Trust (UK) – Grant reviewer 2009 – 2011 Reviewer for the State of Louisiana Grants 2010 Reviewer: National Institutes of Health (Ad-hoc member) 2011 Reviewer: National Institutes of Health (Ad hoc on Various committees) 2011 Reviewer: Medical Research Council Academy (NHMRC) Project grant - (Australia) 2012 Reviewer: National Institutes of Health (Systems Biology study section -

Feb, May, Oct) 2013 Reviewer: National Institutes of Health (Chairperson- Systems Biology

study section, Jan) and (Special emphasis study section May) 2014 Reviewer: National Institutes of Health (Systems Biology study section,

January) and (Special emphasis study section January) 2015 Reviewer: National Institutes of Health (Special emphasis study section

April, June) 2016 Reviewer: National Institutes of Health (Hypertension & Microcirculation

study section February) 2016 Reviewer: National Institutes of Health (Special emphasis study section

November) 2017 Reviewer: NASA, Radiation effects on Brain and CV system Reviewer for Journals - (1983 to present) American Journal of Applied Physiology American Journal of Physiology: Heart and Circulatory Physiology American Journal of Physiology: Regulatory, Integrative & Comparative Physiology American Journal of Physiology: Renal Fluid and Electrolyte Physiology American Journal of Physiology: Physiological Genomics American Journal of Hypertension Antioxidants & Redox Signaling Brain Research Brain Research Bulletin Canadian Journal of Physiology & Pharmacology Circulation Circulation Research Cardiovascular Research Experimental Physiology European Journal of Heart Failure Hypertension Hypertension in Pregnancy Journal of Cardiac Failure Journal of Physiology (The Journal of Physiology) Journal of Neurophysiology


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Kidney International Life Science Neuro-endocrinology (International J. for Basic and Clin. Studies in Neuroendocrinology) Neuropharmacology Neuroscience Neuroscience Letters Peptides (An International Journal) Pharmacological Reviews Proc. Soc. Expt. Bio. Med. Review of Abstracts for National and International Meetings American Heart Meetings - 1987 American Heart Meetings - 1993 3rd International Congress on Heart Failure Geneva, Switzerland, May 1995 4th International Congress on Heart Failure Jerusalem, Israel, May 1996 5th International Congress on Heart Failure Washington, USA, May 1997 6th International Congress on Heart Failure Geneva, Switzerland, May 1998 1st International Congress on Heart Disease Washington, USA, May 1999 7th International Congress on Heart Failure Vancouver, BC, Canada, July 2000 2nd International Congress on Heart Disease Washington, USA, July 2002 15th International Congress on Heart Failure Vancouver, BC, Canada, July 2010 16th International Congress on Heart Failure Vancouver, BC, Canada, July 2011 17th International Congress on Heart Failure Toronto, ONT, Canada, July 2012 AHA – High Blood Pressure Council; Hypertension Meeting, 2012 18th International Congress on Heart Failure Vancouver, BC, Canada, July 2013 Other Consulting Activity

Special advisor/consultant for Ph.D. (Fitch G.K) Thesis, Kansas State University, Manhattan, Kansas; 1994 - 1997 External Examiner for Ph.D. (Doug Martin) Thesis: Department of Pharmacology, University of Saskatchewan, SK, CANADA, 1994 External Examiner for Ph.D. (Fitch G.K) Thesis: Department of Physiology, Kansas State University, Manhattan, Kansas (12 Dec 1997) External Examiner for Ph.D. Nermin Thesis: Department of Pharmacology, Creighton University Omaha, NE (2005) External Examiner for Ph.D. (Joo Lee Cham) Thesis: Department of Physiology, School of Medical Sciences, RMIT University, Melbourne, Australia (2010) External Examiner for Ph.D. (Preeti Solanki) Thesis: Department of Pharmacology, Armed University, Delhi, India (2011)

HONORS AND AWARDS National Institutes of Health - FIRST award (1987 - 91)


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Member of the Graduate Faculty, University of South Dakota (1988) Fellow of the Graduate Faculty, University of South Dakota (1988) Reviewer: American Heart Association Great Plains Regional Research Review Committee (1989 - 93) Faculty Development Award, University of South Dakota (1990) National Institutes of Health - AREA award (1991 - 94) Member of the Graduate Faculty, University of Nebraska (1991) Fellow of the Graduate Faculty, University of Nebraska (1991) National Institutes of Health - RO1 award (1994 - 98) Fellow of the Cardiovascular Section of American Physiological Society (1994) Special Graduate Faculty, Kansas State University, Manhattan, Kansas (1995) Fellowship in the Council for High Blood Pressure Research, American Heart Association (1995) Scientific Advisory Board, International Society of Heart Failure (1995 - present) Outstanding Achievement, College of Medicine, UNMC (1995) Reviewer: American Heart Association, (National Affiliates) “Control of Circulation” - Study Section 1995 - 1998

Special Achievement, College of Medicine, University of Nebraska Medical Center (1995) Editorial Board (member), American Journal of Physiology, Regulatory and Integrative Physiology (1996 - 2002) Special Achievement, College of Medicine, University of Nebraska Medical Center (1996) Scientific Advisory Board, International Academy of Cardiology (1997 - present) The Joseph P. Gilmore Distinguished Basic Scientist Award, University of Nebraska Medical Center (1997) Special Achievement, College of Medicine, University of Nebraska Medical Center (1997) National Institutes of Health; NIH - Institutional Research Training Grant Co-Director (1998 - 2003)


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National Institutes of Health - Diabetes; Renal: RO1 award (1999 - 2004) Reviewer: American Heart Association, (National Affiliates) “Renal & Cardiovascular” - Study Section (1999 - 2002) National Institutes of Health - Program Project Grant - Co-Director (1999 - 2004) National Institutes of Health - Program Project Grant - Heart Failure: Project II (1999 - 2004) Reviewer: National Institutes of Health Ischemic Heart Disease SCORE - Science Study Section (1999) National Institutes of Health - Diabetes; Central Mechanisms: RO1 award (1999 - 2003) Reviewer: National Institutes of Health Neurological disorders in Diabetes - Science Study Section (2000) Reviewer: National Institutes of Health Programs of Excellence in Gene Therapy (Special Emphasis panel) (2000) Editorial Board (Managing Editor), Frontiers in Bioscience (2001 - present) Editorial Board (member), American Journal of Physiol., Renal Physiology (2003 - 2008)

Reviewer: National Institutes of Health - NHLBI - CICS Study Section (2005 - March; July) National Institutes of Health - Program Project Grant - Heart Failure: Project II (2004 - 2009)

Reviewer: National Institutes of Health - NHLBI – Hypertension & Microcirculatory Study Section (2005 - October) Reviewer: National Institutes of Health - NHLBI – ZRG1 RUS E11 Study Section (2006 - February) Irish Medical Research Council -2005, 2007,2008

Australian Heart Foundation Grant reviewer- 2004, 2005, 2007 Welcome Trust – Grant reviewer 2004 - 2005

Editorial Board (Editor), Experimental Physiology 2006 - 2010 Louisiana State University Excellence Grants, 2009 to 2012 President-elect, President, Past-President, Nebraska Physiological Society, 2009-2012 National Institutes of Health - Program Project Grant - Heart Failure: Project II (2009 - 2014)


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National Institutes of Health - Diabetes; Erectile Dysfunction: RO1 award (2009 - 2014) Reviewer: National Institutes of Health 2011 - Ad-hoc reviewer Reviewer: National Institutes of Health 2012 - Ad-hoc reviewer Reviewer: National Institutes of Health - NHLBI – ZRG1 VH (50) NHLBI Systems Biology Study Section - (17-18 January 2013) Chairperson. Editorial Board (member), American Journal of Physiology, Heart & Circulatory Physiology (2013 - Present) Reviewer: National Institutes of Health - NHLBI – ZRG1 VH (50) NHLBI Systems Biology Study Section - (28-29 May 2013) - NHLBI- SEP – 9 May 2013

Endowed Professorship: A. Ross McIntyre, PhD, MD. Professor of Physiology (2013) Associate Editor: American Journal of Physiology; Heart & Circulation (2013 - present).

Reviewer: National Institutes of Health - NHLBI – ZRG1 VH (50) NHLBI Systems Biology Study Section (January 2014) - NHLBI- SEP – January 2014, April 2015, July 2015

Research Leadership Award (UNMC) 2014.

Reviewer: National Institutes of Health - NHLBI – Hypertension & Microcirculation Study Section (February 2016) - NHLBI- SEP – November 2016 National Science and Research Council of Canada (January 2017)

NHLBI - Special Emphasis Panel/Scientific Review Group 2017/10 ZTR1 DPI-8 (May 12, 2017) NASA – CNS – Degen Panel – NASA HERO Program 3rd October 2017. MEMBERSHIP AND OFFICES IN PROFESSIONL SOCIETIES Society Memberships - American Physiological Society - Cardiovascular section, 1987 to present "Neural control of circulation" & "Renal section" American Heart Association - Council on Circulation, 1989 to present International Society of Heart Failure, 1994 to present Heart Failure Society of America, 1995 to present International Society of Autonomic Neuroscience, 1995 to present Council for High Blood Pressure Research, American Heart Association, 1995 to present International Academy of Cardiology, 1997 to present Society of Neuroscience, 1999 to present


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Committee Service - American Heart Association, Clay County, SD -Board Member - 1989,1990 American Heart Association, Research Committee- Dakota Affiliate – 1990 - 93 American Heart Association, Research Committee- Nebraska Affiliate – 1993 - 96 American Heart Association, Research Review Committee - 1989 to 1997

American Heart Association, Research Review Comm.-1993&94-Co-Chair & Chairman American Heart Association, (National) Scholar Student Program - Basic Science Study Section -1997 - 1998 American Heart Association, Research Review Committee - 1999 - 2002 Renal & Cardiovascular Study section American Heart Association, Research Committee - Heartland Affiliate – 2000 - 2003 Councilor, Nebraska Physiological Society Chapter (2005-2009) Service at Society Meetings -

Co-chair of the session on "Cardiovascular adrenergic effects", Federation of American Societies for Experimental Biology. Anaheim, CA, April 1985 Chairman of the session on "Neurohumoral Aspects", 3rd International Congress on Heart Failure, Geneva, Switzerland, May 1995 Chairman of the session on "Neurohumoral Aspects", 4th International Congress on Heart Failure, Jerusalem, Israel, May 1996 Chairman of the session on "Neurohumoral Aspects", 5th International Congress on Heart Failure, Washington, USA, May 1997 Chairman of the session on "Role of forebrain in control of circulation", IUPS Satellite: Central mechanisms of cardiovascular control, Sidney, Australia, August 2001 Chairman of the session on "Neurohumoral Aspects", 8th International Congress on Heart Failure, Washington, USA, July 2002 Chairman of the session on “Nitric oxide signaling in brain in health and disease”, APS Summer Conference: Central mechanisms of cardiovascular control, Sidney, Australia, July, 2007 Co-chair for the session on “Neuronal Plasticity in Health and Disease” at the Federation of American Societies for Experimental Biology. San Diego, CA. April 2008 Chairman for the session on "Sympatho-Excitatory Mechanisms in Cardiovascular Disease", at the FASEB Conference of the American Physiological Society Conference. July 2012 Co-Chair for the Organization of 2012 American Physiological Society Conference on Autonomic Regulation of Cardiovascular Function in Health and Disease. July 2012 Chairman of the session on "Basic Science" (Invited), 13th International Congress on Heart Failure, Vancouver, USA, July 2013


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COMMITTEE ASSIGNMENTS University of South Dakota Departmental: Graduate Student Committee, 1989 - 1991 Search Committee, 1990 Promotions and Tenure Committee, 1990 - 1991 Collegiate: Admissions committee, 1988, 1989, 1990,1991 Institutional LCME self-study task force, 1989 - 1990 Research Committee, 1989 – 1991 University: General Research Committee, 1989 - 1991 University of Nebraska Medical Center Departmental: Chairman, Graduate Student Committee, 1992 - 1998 Faculty search Committee, 1993 Faculty search Committee, 1995 Chairman, Faculty Search Committee 2006, 2011 Chairman, Departmental Promotion and Tenure Committee 2006, 2011, 12, 13, 14,15 Collegiate: Research Review Committee (Sees Grants), 1994 Research and Development Committee, 1993 - 1996, 1996 - 1999 MD/PhD Program Committee, 1993 - 1996

Cardiovascular Subcommittee for the College of Medicine's Strategic Plan -1994 - 95

Vice Chair, Cardiovascular Diseases, Subcommittee, College of Medicine 1995 - 2000 First UNMC Cardiovascular Symposium 1997- Organizer Graduate Council, 1995 - 1998 Curriculum Committee’s mini-task force on Cardiovascular Disease 1997 - 2000 Second UNMC Cardiovascular Symposium 1998 - Organizer Chair, Research Review Committee (Seed Grants), 1998 Chair, New Faculty Search Committee - 2006 Post-doctoral education committee 2005 - present Promotion and Tenure committee 2006 – 2012 Chair, Departmental Promotion and Tenure committee 2012 - present Chair, New Faculty Search Committee - 2011 – 2012 Member of the Graduate Committee for Neuroscience 2015- present University: Thomas Jefferson Award Committee, 1994 - 95


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Graduate Council, 1995 - 1998 University of Nebraska Outstanding Research and Creative Activity Award; ORCA awards; Selection committee: 1998 - 2001

COMMUNITY SERVICE

Presentations to Rotary Club about cardiovascular diseases - 1989, 1990 - South Dakota Presentations to AHA volunteer workers - 1990, 1991 - North and South Dakota Lecturer for Multi-cultural program for Milliard School Teachers - 1993 to present

Volunteer science presentations to grade school classes Volunteer geography and cultural presentations to grade school classes Volunteer health science presentations to grade school classes Volunteer Soccer Coach, West Omaha Soccer Club - 1991 to 1994, 1996 - 1999 Substitute Tennis Coach, “The Tennis Club” - 1991 to 1995, 2003, 2004 to present Volunteer Tennis Coach, “Tennis Our Way” - 1996, 1997 Board of directors, Omaha Tennis Association – 2001 - 2003

Volunteer Tennis Coach, Millard North (Varsity teams (Boys & Girls) - 2000 to 2012


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BIBLIOGRAPHY Articles Published - 1. PATEL, KP, Ciriello, J, and Kline, RL. Noradrenergic mechanisms in brain and peripheral

organs after aortic nerve transection. Am J Physiol 240: H481-H486, 1981. 2. PATEL, KP, Kline, RL, and Mercer, PF. Noradrenergic mechanisms in brain and peripheral

organs of normotensive and spontaneously hypertensive rats at various ages. Hypertension 3:682-690, 1981.

3. Kline, RL, PATEL, KP, Ciriello, J, and Mercer, PF. Effect of renal denervation on arterial pressure in rats with aortic nerve transection. Hypertension 5: 468:475,1983.

4. PATEL, KP, and Kline, RL. Influence of renal nerves on noradrenergic responses to changes in arterial pressure. Am J Physiol 247:R615-R620, 1984.

5. Kline, RL, PATEL, KP, and Mercer, PF. Enhanced noradrenergic activity in kidney of Brattleboro rats with diabetes insipidus. Am J Physiol 250:R567-R572, 1986.

6. Pardini, BJ, PATEL, KP, Schmid, PG and Lund, DD. Facilitation of baroreflex-induced bradycardia by stimulation of specific hypothalamic sites in the rat. Brain Res 384:274-281, 1986.

7. Schmid, PG, and PATEL, KP. Cardiovascular effects of neurohypophysial peptides. The Peptides 8:335-362, 1986.

8. PATEL, KP, and Knuepfer, M. Effect of afferent renal nerve stimulation on blood pressure, heart rate and noradrenergic activity in conscious rats. J Auto Ner Sys17:121-130, 1986.

9. PATEL, KP, Whities, CA, Lund, DD. and Schmid, PG. Effects of intravenous infusions of vasopressin and angiotensin II on central and peripheral noradrenergic function in conscious rabbits. Can J Physiol Pharmacol 65:765-772, 1987.

10. Pardini, BJ, PATEL, KP, Schmid, PG, and Lund, DD. Location and distribution of intercardiac ganglion cells in the rat. J Auto Nerv Syst 20:91-101, 1987.

11. Wilkin, LD, PATEL, KP, Schmid, PG, and Johnson, AK. Increased norepinephrine turnover in the median preoptic nucleus following reduced extracellular fluid volume. Brain Res 423:369-372, 1987.

12. PATEL, KP, and Schmid, PG. The role of central noradrenergic pathways in the actions of vasopressin on baroreflex control of the circulation. In: Brain Peptides and Catecholamines in Cardiovascular Regulation in Normal and Disease States. Ed. J.P. Buckley and C.M. Ferrario. Raven Press, New York, pp. 53-64. 1987.

13. PATEL, KP, and Schmid, PG. Role of the paraventricular nucleus (PVH) in baroreflex- mediated changes in lumbar sympathetic nerve activity and heart rate. J Auto Nerv Sys 22:211-219, 1988.

14. PATEL, KP, and Schmid, PG. Role of median preoptic area in vasopressin-mediated bradycardia. Am J Physiol 254:H1172-H1178, 1988.

15. PATEL, KP, and Schmid, PG. Vasopressin inhibits sympathetic ganglionic transmission but potentiates sympathetic neuroeffector responses in hindlimb vasculature of rabbits. J Pharmacol Expt Ther 245:779-785, 1988.

16. Schmid, PG, and PATEL, KP. Role of the forebrain in the influence of vasopressin on cardiovascular reflexes. In: Vasopressin. Ed. A. W. Cowley. Raven Press, New York. pp, 427-432, 1988.

17. Peuler, JD, PATEL, KP, Lund, DD, Pardini, BJ, and Schmid, PG. Altered peripheral noradrenergic activity in intact and sinoaortic denervated Dahl rats. Can J Physiol & Pharmacol 67:442-449, 1989.

18. PATEL, KP, Peuler, JD, Morgan, D, Pardini, BJ, Lund, DD, and Schmid, PG. Central


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noradrenergic activity in intact and sinoaortic denervated Dahl rats. Can J Physiol & Pharmacol 67:450-455, 1989.

19. PATEL, KP. Atrial natriuretic factor attenuates sympathetic neuroeffector responses in hindlimb vasculature of rabbits. Can J Physiol & Pharmacol 67:1101-1105, 1989.

20. PATEL, KP, and Zhang, PL. Reduced renal responses to volume expansion in streptozotocin-induced diabetic rats. Am J Physiol 257:R672-R679, 1989.

21. PATEL, KP, and Zhang, PL. Attenuated renal responses to atrial natriuretic factor in streptozotocin-induced diabetic rats. Can J Physiol. & Pharmacol 68:425-430, 1990.

22. Krukoff, TL, and PATEL, KP. Alterations in brain hexokinase activity associated with streptozotocin-induced diabetic mellitus in the rat. Brain Res 522:157-160, 1990.

23. Zhang, PL, and PATEL, KP. Blunted diuretic and natriuretic responses to central administration of clonidine in streptozotocin-induced diabetic rats. Diabetes 40:338-343, 1991.

24. PATEL, KP. Interaction among atrial natriuretic factor (ANF), vasopressin and renal nerves in terms of renal responses in rats. Life Sci 48:261-267, 1991.

25. PATEL, KP. Role of renal nerves and vasopressin in renal responses to acute volume expansion in rats. Proc Soc Exp Bio Med 196:438-443, 1991.

26. Zeigler, DW, and PATEL, KP. Reduced renal responses to acute saline load in obese Zucker rats. Am J Physiol 261:R712-R718, 1991.

27. Kauker, ML, Zhang, PL, Zeigler, DW, and PATEL, KP. Blunting of the renal response to volume expansion by bradykinin receptor antagonist: Influence of denervation. J Pharmacol Expt Ther 258:866-870, 1991.

28. Zhang, PL, Patel, MB, and PATEL, KP. Renal responses to acute volume expansion and atrial natriuretic factor in streptozotocin-induced diabetic rats. Diabetes Res & Clin Practice 14:37-46, 1991.

29. PATEL, KP. Central alpha-2 adrenergic mechanisms in the renal nerve mediated natriuresis and diuresis produced by acute volume expansion. J Auto Nerv Sys 36:47-54, 1991.

30. Patel, MB, Zhang, PL, Patel, AC, and PATEL, KP. Altered pressure-volume relation of right atrium and venoatrial junction in diabetic rats. Am J Physiol 263:H1017-H1020, 1992

31. PATEL, KP, and Zhang, PL. Renal responses to acute volume expansion in young spontaneously hypertensive rats. J Clin & Expt Hyper 15(1):91-104, 1993.

32. PATEL, KP, and Zeigler, DW. Renal nerves are involved in the natriuresis and diuresis produced by central administration of clonidine in rat. Proc Soc Exp Bio Med 202:81-87, 1993.

33. PATEL, KP, and Zeigler, DW. Diuretic and natriuretic responses to ANF in the presence and absence of renal nerves in DOCA-salt hypertensive rats. J Clin & Expt Hyper 15:257-270, 1993.

34. PATEL, KP, and Zhang, PL. Role of renal nerves in the renal responses to acute volume expansion during pregnancy in rats. Proc Soc Exp Bio Med 203:150-156,1993

35. PATEL, KP, Zhang, PL, and Krukoff TL. Alterations in brain hexokinase activity associated with heart failure in rats. Am J Physiol 265:R923-R928, 1993.

36. PATEL, KP, and Zhang, PL. Reduced renal sympathoinhibition in response to acute volume expansion in diabetic rats. Am J Physiol 267:R372-R379, 1994.

37. Haselton, JR, Goering, J, and PATEL, KP. Parvocellular neurons of the paraventricular nucleus are involved in the reduction in renal nerve discharge during isotonic volume expansion. J Auto Nerv Sys 50:1-11, 1994.

38. Hein, MS, Schlenker, EH, and PATEL, KP. Altered control of ventilation in streptozotocin-induced diabetic rats. Proc Soc Exp Bio Med 207:213-219, 1994.

39. PATEL, KP, and Zhang, PL. Baroreflex function in streptozotocin (STZ) induced diabetic rats. Diabetes Res & Clin Practice 27:1-9, 1995.


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40. Zucker, IH, Wang, W, Brandle, M, Schultz, HD, and PATEL, KP. Neural regulation of sympathetic nerve activity in heart failure. Prog Card Dis 37: 397-414, 1995.

41. Mayhan, WG, and PATEL, KP. Acute effects of glucose on reactivity of cerebral microcirculation: Role of activation of protein kinase C. Am J Physiol 269:H1297-H1302, 1995

42. PATEL, KP, Zhang, PL, and Mayhan, WG. Blunting of renal excretory responses to acute volume expansion by nicotine: Role of renal nerves. J Pharmacol Exp Ther 274:1174-1181, 1995.

43. Mayhan, WG, Didion, SP, and PATEL, KP. L-Arginine does not restore dilation of the basilar artery during diabetes mellitus. J Cerebral Blood Flow & Meta 16:500-506,1996.

44. PATEL, KP, & Zhang, K. Neurohumoral activation in heart failure: Role of paraventricular nucleus. Clin & Expt Pharmacol & Physiol 23:722-726, 1996

45. PATEL, KP, Zhang, PL, and Carmines, PK. Neural influences on the renal response to acute volume expansion in rats with heart failure. Am J Physiol 271:H1441-H1448, 1996

46. PATEL, KP, Zhang, K, Zucker, IH. & Krukoff TL. Decreased gene expression of neuronal nitric oxide synthase in hypothalamus and brainstem of rats in heart failure. Brain Res 734:109-115, 1996

47. Brandle, M, PATEL, KP, Wang, W, and Zucker, IH. Hemodynamic and norepinephrine responses to pacing-induced heart failure in conscious sino-aortic denervated dogs. Am J Appl Phyiol 81:1855-1862, 1996.

48. Xu, Z, PATEL, KP, and Rozanski, GJ. Intracellular protons inhibit transient outward potassium current in ventricular myocytes from diabetic rats. Am J Physiol 271:H2154-H2161, 1996.

49. Xu, Z, PATEL, KP, and Rozanski, GJ. Metabolic basis of decreased transient outward K+ current in ventricular myocytes from diabetic rats. Am J Physiol 271:H2190-H2196, 1996

50. Reynolds, AY, Zhang, K, and PATEL, KP. Renal sympathetic discharge mediated by the paraventricular nucleus is altered in STZ induced diabetic rats. Nebraska Medical Journal 81:419-423, 1996.

51. PATEL, KP, Zhang, K, Hein, MS, and Mayhan, WG. Peripheral noradrenergic turnover in streptozotocin-induced diabetic rats. Diabetes Res & Clin Practice 35:1-9, 1997.

52. Fitch GK, PATEL, KP, and Weiss ML. Increased renal interstitial hydrostatic pressure causes c-fos expression in the rat’s spinal cord dorsal horn. Brain Res 753:340-347, 1997.

53. Mayhan, WG, and PATEL, KP. Effect of nicotine on endothelium-dependent arteriolar dilatation. Am J Physiol 272:H2337-H2342, 1997.

54. PATEL, KP. Volume reflex in diabetes. Cardiovascular Res 34:81-90, 1997. 55. PATEL, KP, Zhang, PL, Zeigler, DW, and Kauker, ML. Renal response to volume

expansion in streptozotocin-induced diabetic rats: Influence of calcium channel blockade. Diabetes Res & Clin Practice 35:69-74, 1997.

56. Mayhan, WG, PATEL, KP, and Sharpe GM. Effect of L-arginine on reactivity of hamster cheek pouch arterioles during diabetes mellitus. Int J Microcirc 17:107-112, 1997.

57. Zhang, K, Mayhan, WG, and PATEL, KP. Nitric oxide within the paraventricular nucleus mediates changes in renal sympathetic nerve activity. Am J Physiol 273:R864-R872, 1997.

58. Rozanski, GJ, Xu, Zhang, K, and PATEL, KP. Altered ionic currents of ventricular myocytes in rats with experimental heart failure. Am J Physiol 274:H259-H265, 1998.

59. PATEL, KP. Neural regulation in experimental heart failure. In: Neurocardiology. Ed. D. Cechetto and V.Hachinski. W.B. Saunders, London, pp. 283-296. 1998.

60. Zhang, K, Zucker, IH, and PATEL, KP. Altered number of diaphorase (NOS) positive neurons in hypothalamus of rats with heart failure. Brain Res 786:219-225, 1998.

61. Mayhan, WG, and PATEL, KP. Treatment with dimethylthiourea prevents impaired dilation of the basilar artery during diabetes mellitus. Am J Physiol 274:H1895-H1901, 1998.

62. Zhang, K, and PATEL, KP. Effect of nitric oxide within the paraventricular nucleus on renal


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sympathetic nerve discharge: Role of GABA. Am J Physiol. 275:R728-R734, 1998.

63. Ikenaga, H, Didion, SP, Zhang, K, Cornish, KG, Ishii, N, PATEL, KP, Mayhan, WG, and Carmines, PK. Suppressed impact of nitric oxide on renal arteriolar function in rats with chronic heart failure. Am J Physiol 276:F79-F87, 1999.

64. PATEL, KP, Zhang, K, and Carmines, PK. Turnover of norepinephrine in peripheral tissues of rats with heart failure. Am J Physiol 278:R556-R562, 2000.

65. McConnell, PI, Olson, CE, PATEL, KP, Blank, DU, Olivari, M-T, Gallagher, KP, Quenby-Brown, E, and Zucker, IH. Chronic endothelin blockade in dogs with pacing-induced heart failure: Possible modulation of sympatho-excitation. J Cardiac Failure 6:56-65, 2000.

66. Fitch GK, PATEL, KP, and Weiss ML. Activation of renal afferent pathways following furosemide treatment: Effect of survival time and renal denervation. Brain Res 861:363-376, 2000.

67. PATEL, KP, Zhang, K, Kenney, MJ, Weiss, ML, and Mayhan, WG. Neuronal expression of Fos protein in hypothalamus of rats with heart failure. Brain Res 865:27-34, 2000.

68. PATEL, KP. Role of paraventricular nucleus in mediating sympathetic outflow in heart failure. Heart Failure Reviews 5:73-86, 2000.

69. Liu, J-L, Irvine, S, Reid, IA, PATEL, KP, and Zucker, IH. Exercise training reduces sympathetic nerve activity in rabbits with pacing-induced heart failure: A role for angiotensin II. Circulation 102:1854,1862, 2000.

70. Shontz RD, Xu Z., PATEL, KP, and Rozanski, GJ. Inhibition of K+ currents by homocysteine in rat ventricular myocytes. J Cardiac Electrophysiology 12:175-182, 2001.

71. PATEL, KP, and Carmines, PK. Renal interstitial hydrostatic pressure and sodium excretion during acute volume expansion in diabetic rats. Am J Physiol 281:R239-R245, 2001.

72. Ishii, N, PATEL, KP, Lane, PH, Taylor, T, Bian, K, Murad, F, Pollock, JS, and Carmines PK. Nitric oxide synthesis and degradation in the renal cortex of rats with diabetes mellitus. J Am Soc Neph 12:1630-1639, 2001.

73. Zucker, IH, Wang, W, Pliquett, RU, Liu JL, Irvine, S, and PATEL, KP. The regulation of sympathetic outflow in heart failure: the role of angiotensin II, nitric oxide and exercise training. Ann. New York Academy Sci 940:431-443, 2001.

74. Zhang, K, Li, Y-F, and PATEL, KP. Blunted nitric oxide-mediated inhibition of renal nerve discharge within the paraventricular nucleus of rats with heart failure. Am J Physiol 281:H995-H1004, 2001.

75. PATEL, KP, Li, Y-F, and Hirooka, Y. The role of nitric oxide on central sympathetic outflow. Proc Soc Exp Bio Med 226(9):814-824, 2001. (Invited review)

76. Kenney, MJ, Weiss, ML, PATEL, KP, Wang, Y, and Fels, RJ. Paraventricular nucleus bicuculline alters the frequency components of sympathetic nerve discharge bursts. Am J Physiol 281:H1233-H1241, 2001.

77. Sun, H, PATEL, KP, and Mayhan, WG. Tetrahydrobiopterin, a cofactor for NOS, improves endothelial dysfunction during chronic alcohol consumption. Am J Physiol 281:H1863-H1869, 2001.

78. Weiss, ML, Chowdhury, SI, PATEL, KP, Kenney, MJ, Huang, J. Neural circuitry of the kidney; NO containing neurons. Brain Res 919:269-282, 2001.

79. Li, Yi-Fan, Mayhan, WG, and PATEL, KP. NMDA-mediated increase in renal sympathetic nerve discharge within the PVN: Role of nitric oxide. Am J Physiol. 281:H2328-H2336, 2001.

80. Li, Yi-Fan, Roy, SK, Channon, K, Zucker, IH, and PATEL, KP. Effect of in-vivo gene transfer of neuronal nitric oxide synthase (nNOS) in the PVN on renal nerve discharge in rats. Am J Physiol 282:H594-H601, 2002.


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81. Xu Z, PATEL, KP, Lou, MF, and Rozanski, GJ. Up-regulation of K+ channels in diabetic rat ventricular myocytes by insulin and glutathione. Cardiovas Res 53:80-88, 2002.

82. Zhang, K, Li, Yi-Fan and PATEL, KP. Blunted GABA-mediated inhibition of renal nerve discharge within the paraventricular nucleus of rats with heart failure. Am J Physiol 282:R1006-R1015, 2002.

83. Zhu, G, PATEL, KP. Zucker, IH, and Wang, W. Microinjection of angiotensin II into the paraventricular nucleus enhances cardiac sympathetic afferent reflex in rats. Am J Physiol 282:H2039-H2045, 2002.

84. Sun, H, PATEL, KP, and Mayhan, WG. Impairment of neuronal nitric oxide synthase-dependent dilation of cerebral arterioles during chronic alcohol consumption. Alcoholism: Clin & Expt Res 26:663-670, 2002.

85. Ishii, N, Fujiwara, K, Lane, PH., PATEL, KP, and Carmines PK. Renal cortical nitric oxide synthase activity during maturational growth in the rat. Ped Neph 17:591-596, 2002.

86. Zheng, H, Weiss, ML, and Mayhan, WG, PATEL, KP. Neuronal expression of Fos protein in hypothalamus of diabetic rats. Brain Res 956(2):268-275, 2002.

87. DiCarlo, SE, Zheng, H. Collins, HL, Rodenbaugh, DW, and PATEL, KP. Daily exercise normalizes the number of diaphorase (NOS) positive neurons in the hypothalamus of hypertensive rats. Brain Res. 955(1-2):153-160, 2002.

88. Li, Y-F, Zhang, K. Mayhan, WG, and PATEL, KP. Blunted inhibition of renal sympathetic nerve activity discharge induced by clonidine in rats with heart failure. In: Advances in Heart Failure. Ed. A. Kimchi MEDIMOND Inc., Monduzzi Editore, Bologna, Italy, pp. 77-86, 2002.

89. Mueller, PJ, Cunningham, JTH, PATEL, KP, and Hasser, EM. Proposed role of paraventricular nucleus in cardiovascular deconditioning. Acta Physiol Scand. 177(1):27-35, 2003.

90. Li, Y-F, and PATEL, KP. Paraventricular nucleus of the hypothalamus and elevated sympathetic activity in heart failure: The altered inhibitory mechanisms. Acta Physiol Scand 177(1):17-26, 2003.

91. Weiss, ML, Kenney, MJ, Musch,TI, and PATEL, KP. Modifications to central neural circuitry during heart failure. Acta Physiol Scand 177(1):57-67, 2003.

92. Barber, M, Kasturi, B, Austin, MA, PATEL, KP, MohanKumar, SMJ, and MohanKumar, PS. Leptin reverses disbetes-induced neuroendocrine changes in rats. Brain Res. 964(1): 128-135, 2003.

93. Wang, Y, PATEL, KP, Cornish, KG, Channon, KM, and Zucker, IH. nNOS Gene transfer to RVLM improves baroreflex function in rats with chronic heart failure. Am J Physiol H1660-H1667, 2003.

94. Li, Yi-Fan, Mayhan, WG, and PATEL, KP. Acute volume expansion mediated decrease in renal sympathetic nerve discharge: Role of nitric oxide within the PVN. Am J Physio. 285:H1738-H1746, 2003.

95. Pliquett, RU, Cornish, KG, PATEL, KP, Schultz, HD, Peuler, JD, and Zucker, IH. Amerlioration of depressed cardiopulmonary reflex control of sympathetic nerve activity in heart failure by exercise training. J Appl Physiol. 95:1883-1888, 2003.

96. Trauernicht, AK, Sun, H, PATEL, KP, and Mayhan, WG. Enalapril prevents impaired nitric oxide synthase-dependent dilation of cerebral arterioles in diabetic rats. Stroke 34:2698-2703, 2003.

97. Li, Y-F, Cornish, K, and PATEL, KP. Enhanced NMDA effect within the paraventricular nucleus on renal sympathetic nerve discharge in rats with heart failure. Circ Res. 93:990-997, 2003.

98. Bidasee, KR, Zhang,Y, Shao, CH, Wang, M-F, PATEL, KP, Dincer, UD, and Besch, HR. Diabetes increases formation of advanced glycation end products on sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA 2a). Diabetes 53:463-473, 2004.


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99. Zucker, IH, Schultz, HD, Li, Y-F, and PATEL, KP. The origin of sympathetic outflow in heart failure: the roles of angiotensin and nitric oxide. Progress in Biophysics and Molecular Biology 84:217-232, 2004.

100. Zucker, IH, PATEL, KP, Schultz, HD, Li. YF, Wang, W. Pliquett, RU. Exercise training and sympathetic regulation in experimental heart failure. Exerc Sport Sci Rev. 32:107-111, 2004.

101. Mayhan, WG, Sun, H, Mayhan, JF, and PATEL, KP. Influence of exercise on dilation of basilar artery during diabetes mellitus. J Appl Physiol. 96:1730-1737, 2004.

102. Yarnitsky, D, Gross, Y, Lorian, A, Shalev, A, Lamensdore, I, Bornstein, R, Vet, D, Shorer, S, Mayevsky, A, PATEL, KP, Abbot, NJ, and Mayhan, WG: Temporary opening of the blood-brain barrier by sphenopalatine parasympathetic stimulation in the rat. J Neurosurg. 101:303-309, 2004.

103. Mayhan, WG, Mayhan, JF, Sun, H, and PATEL, KP. In vivo properties of potassium channels in cerebral blood vessels during diabetes mellitus. Microcirculation 11:605-613, 2004.

104. Zhu, G-Q, Gao, L, Li, Y-F, PATEL, KP, Zucker, IH, and Wang,W: AT1 receptor mRNA antisense normalizes the enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure. Am J Physiol. 287:H1828-25, 2004.

105. Zhu, G-Q, Gao, L, PATEL, KP, Zucker, IH, & Wang, W: ANG II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failure. J Appl Physiol. 97:1746-1754, 2004.

106. Wang Y, Liu, X-F, Cornish, K, Zucker, IH, and PATEL, KP. Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure. Am J Physiol. 288: H205-213, 2005.

107. Li, Y-F, Wang, Y, Channon KM, Schultz, HD, Zucker, IH, and PATEL, KP. Manipulation of neuronal nitric oxide synthase within the paraventricular nucleus using adenovirus and antisense technology. Methods in Molecular Medicine 112:59-79, 2005.

108. Zheng, H, Cornish, K. Zucker IH, and PATEL, KP. Exercise training improves blunted nitric oxide-mediated inhibition of renal nerve discharge within the paraventricular nucleus of rats with heart failure. Am J Physiol. 288:H2332-H2341, 2005.

109. Gao, L, Schultz, HD, PATEL, KP, Zucker, IH, and Wang,W. Augmented input from cardiac sympathetic afferents inhibits baroreflex in rats with heart failure. Hypertension 45:1180-1188, 2005.

110. Reddy, MK, PATEL, KP, and Schultz, HD. Differential role of paraventricular nucleus of the hypothalamus in modulating the sympathoexcitatory component of peripheral and central chemoreflexes. Am J Physiol 289:R789-R797, 2005.

111. Li, Y-F, Liu, D, Cornish, KG, PATEL, KP, Zucker IH, Channon, KM, and Schultz, HD. Gene tranfer of nNOS to carotid body reverses enhanced chemoreceptor function in heart failure rabbits. Circ. Res. 97:260-267, 2005.

112. Li, Y-F, Wang, W, Mayhan WG, and PATEL, KP. Angiotensin-mediated increase in renal sympathetic nerve discharge within the PVN: role of nitric oxide. Am J Physiol. 290:R1035-R1043, 2006.

113. Zheng, H., Mayhan, WG, Bidasee, KR, and PATEL, KP. Blunted nitric oxide-mediated inhibition of renal nerve activity within the paraventricular nucleus in diabetic rats. Am J Physiol. 290:R992-R1002, 2006.

114. Sun, H, Molacek E, Zheng, H, Fang, Q, PATEL, KP, and Mayhan, WG. Alcohol-induced impairment of neuronal nitric oxide synthase (nNOS)-dependent dilation of cerebral arterioles: role of NAD(P) oxidase. J Mol Cell Cardiol. 40:321-8, 2006.

115. Sun, H, Zheng, H, Molacek E, Fang, Q, PATEL, KP, and Mayhan, WG. Role of NAD(P)H


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oxidase in alcohol-induced impairment of endothelial nitric oxide synthase-dependent dilation of cerebral arterioles: role of NAD(P) oxidase. Stroke 37:495-500, 2006.

116. Li, YL; Xia XH, Zheng, H, Li, Y-F, Liu, D, PATEL, KP, Wang, W, and Schultz, HD, Angiotensin II enhances carotid body chemoreflex control of sympathetic outflow in chronic heart. Cardiovas Res 71:129-138, 2006.

117. Li, Y-F, Jackson, KL, Stern, JE, Rabeler, B, and PATEL, KP. Interaction between glutamate and GABAergic systems in the integration of sympathetic outflow by the paraventricular nucleus of the hypothalamus. Am J Physiol. 291(6):H2847-H2856, 2006.

118. Zheng, H, Li, Y-F, Zucker, IH, and PATEL, KP. Exercise training improves excretory responses to acute volume expansion in rats with heart failure. Am J Physiol. 291(6):F1148-F1156, 2006.

119. Mayhan, WG, Arrick, D.M., Sharpe, G.M. PATEL, KP and Sun, H. Inhibition of NAD(P) oxidase alleviates impaired NOS dependent responses of pial arterioles in type 1 diabetes mellitus (T1D). Microcirculation 13(7):567-75, 2006.

120. Bean L, Zheng, H, PATEL, KP, and Monaghan, DT. Regional variations in NMDA receptor downregulation in streptozotocin-diabetic rat brain. Brain Res. 1115(1):217-222, 2006.

121. Mueller, PJ, Foley, C.M. Heesch, CM, Cunningham, JT, Zheng, H, PATEL, KP, and Hasser, EM. Increased nitric oxide synthase in the hypothalamus of hindlimb unloaded rats. Brain Res. 1115(1):65-74, 2006.

122. Shao, CH, Rozanski, GJ, PATEL, KP, and Bidasee, KR. Dyssynchronous (Non-uniform) Ca2+ release in myocytes from streptozotocin-induced diabetic rats. J Mol Cell Cardiol. 42(1):234-46, 2007.

123. Reddy, MK, Schultz, HD, Zhang H, and PATEL, KP. Altered nitric oxide mechanism within the paraventricular nucleus contributes to augmented carotid body chemoreflex in heart failure. Am J Physiol. 292:H149-H157, 2007.

124. Pan, YX, Gao, L, Wang, WZ, Zheng H, Liu, D, PATEL, KP, Zucker, IH, and Wang, W. Exercise training prevents arterial baroreflex dysfunction in rats treated with central angiotension II. Hypertension 49(3):519-527, 2007.

125. Zheng, H, Bidasee, KR, Mayhan, WG, and PATEL, KP. Lack of central nitric oxide triggers erectile dysfunction in diabetes. Am J Physiol. 290:R1158-R1164, 2007.

126. Kleiber A, Zheng, H, Liu, X, and PATEL, KP. Exercise training normalizes NMDA-mediated changes in renal sympathetic nerve activity and NR1 expression within the PVN in heart failure. Am J Physiol. 294: R1863-R1872, 2008.

127. Bidasee, KR, Zheng, H, Shao, CH, Parbhu, SK, Rozanski, GJ, and PATEL, KP. Exercise training initiated after the onset of diabetes preserves myocardial function: Effects on expression of beta-adrenoceptors. J Appl Physiol. 105(3):907-914, 2008.

128. Guggilam, A, Haque, M, PATEL, KP, Ebenezer, PJ, Kapusta, D, and Francis J. Cytokine blockade enhances neuronal nitric oxide synthase in the paraventricular nucleus of rats with heart failure. European Heart J. 10(7):625-634, 2008.

129. Heesch, CM, Zheng, H, Foley, CM, Mueller, PJ, Hasser EM, and PATEL, KP. Nitric oxide synthase activity and expression are decreased in the paraventricular nucleus of pregnant rats. Brain Res. 1251:140-50, 2009.

130. Shao, CH, Wehrens, XH, Wyatt, TA, Parbhu, SK, Rozanski GJ, PATEL, KP, and Bidasee KR. Exercise training during diabetes attenuates cardiac ryanodine receptor dysrefulation. J Appl Physiol. 2009 Apr;106(4):1280-92. PMID: 19131475

131. Zheng, H, Li, Y-F, Wang, W, and PATEL, KP. Enhanced angiotensin-mediated excitation of renal nerve activity within the paraventricular nucleus of rats with heart failure. Am J Physiol Regul Integr Comp Physiol. 297(5):R1364-74, 2009. PMID: 19710393

132. Zucker, IH, Schultz HD, PATEL, KP, Wang, W, and Gao, L. Regulation of central angiotensin type 1 receptors and sympathetic outflow in heart failure. Am J Physiol Heart Circ Physiol. 297(5): H1557-66. 2009. PMCID: PMC2781376


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133. Park, JB, Jo, JY, Zheng, H, PATEL, KP, and Stern, JE. Regulation of tonic GABA inhibitory function, presympathetic neuronal activity and sympathetic outflow from the PVN by astroglial GABA. J Physiol. 587(Pt 19):4645-60. 2009. PMID: 19703969

134. Kleiber, A, Zheng, H, Liu, X, and PATEL, KP. Chronic AT1 receptor blockade normalizes NMDA-mediated changes in renal sympathetic nerve activity and NR1 expression within the PVN on rats with heart failure. Am J Physiol Heart Circ Physiol. 298(5):H1546-55. 2010. PMID: 20173042

135. Shao, CH, Rozanski, GJ, Nagai, R, Stockdale, FE, PATEL, KP, Wang, M, Singh, J, Mayhan WG, and Bidasee, KR. Carbonylation of myosin heavy chains in rat hearts during diabetes. Biochemical Pharmacology 80(2):205-217, 2010. PMID: 20359464

136. Mayhan, WG, Arrick, DM, Sun, H, and PATEL, KP. Exercise training restores impaired dilator responses of cerebral arterioles during chronic exposure to nicotine. J Appl Physiol. 109(4): 1109-14. 2010. PMCID: PMC2963320

137. PATEL, KP, Mayhan, WG, Bidasee, KR, and Zheng, H. Enhanced angiotensin II-mediated central sympathoexcitation in streptozotocin-induced diabetes: role of superoxide anion. Am J Physiol Regul Integr Comp Physiol. 300(2): R311-20. 2011. PMCID: PMC3051357

138. Zheng, H, Liu, X, Rao US, and PATEL, KP. Increased renal ENaC subunits and sodium retention in rats with chronic heart failure. Am J Physiol. Renal Physiol. 300(3):F641-9. 2011. PMID:21159737

139. Mayhan, WG, Arrick, DM, PATEL, KP, and Sun, H. Exercise training normalizes impaired NOS-dependent responses of cerebral arterioles in type 1 diabetic rats. Am J Physiol Heart Circ Physiol. 300(3): H1013-20. 2011PMCID: PMC3064313

140. Shao, CH, Capek, HL, PATEL, KP, Wang, M, Tang, K, Desouza, C, Nagai, R, Mayhan, W, Periasamy, M, and Bidasee, KR. Carbonylation contributes to SERCA2a activity loss and diastolic dysfunction in a rat model of type 1 diabetes. Diabetes. 60(3): 947-59. 2011. PMCID: PMC3046856

141. Arrick, DM, Sun, H, PATEL, KP, and Mayhan, WG. Chronic resveratrol treatment restores vascular responsiveness of cerebral arterioles in type 1 diabetic rats. Am J Physiol Heart Circ Physiol. 301(3):H696-703, 2011. PMID: 21666113

142. Biancardi, VC, Son, S, Sonner, PM, Zheng, H, PATEL, KP, and Stern, JE. Contribution of the central nervous system eNOS in neurohumoral activation in heart failure rats. Hypertension. 58(3):454-63, 2011. PMID 21825233

143. Zheng, H, Mayhan, WG, and PATEL, KP. Exercise training improves the centrally mediated erectile dysfunction in rats with Type 1 Diabetes. J Sexual Medicine 8(11):3086-97, 2011. PMID 21883945

144. Sharma, NM, Zheng, H, Mehta, PP, Li Y-F, and PATEL, KP. Decreased nNOS within the paraventricular nucleus leads to increase sympathoexcitation in chronic heart failure: role for CAPON and Ang II. Cardiovas Res 92(2):348-57, 2011. PMID:21831995

145. Huang, BS, Zheng, H, PATEL, KP, and Leenen, HH. Regulation of hypothalamic renin-angiotensin system and oxidative stress by aldosterone. Exp Physiol. 96(10):1028-38, 2011. PMID:21824999

146. Zheng, H, Liu, X, and PATEL, KP. Angiotensin-converting enzyme 2 overexpression improves central nitric oxide mediated sympathetic outflow in chronic heart failure. Am J Physiol Heart Circ Physiol. 301(6):H2402-12, 2011. PMID:21963832

147. Zheng, H, Liu, X, Li Y, Sharma, NM, and PATEL, KP. Gene transfer of neuronal nitric oxide synthase to the paraventricular nucleus reduces the enhanced glutamatergic tone in rats with chronic heart failure. Hypertension. 58(5):966-73. 2011. PMID:21968757

148. PATEL, KP, and Zheng, H. Central neural control of sympathetic nerve activity in heart failure following exercise training. Am J Physiol Regul Integr Comp Physiol. 302(3):H527-


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37. 2012. PMID:22101524.

149. Llewellyn, T, Zheng, H, Liu, X, Xu, B, and PATEL, KP. Median preoptic nucleus and subfornical organ drive renal sympathetic nerve activity via a glutamatergic mechanism with the paraventricular nucleus. Am J Physiol Heart Circ Physiol. 302(4):R424-32. 2012. PMID:22160544

150. Zucker, IH, PATEL, KP, and Schultz, HD. Neurohumoral Stimulation. Heart Failure. Heart Fail Clin. 8(1):87-99. 2012. PMID:22108729

151. Sharma, NM, Zheng, H, Li, Y-F, and PATEL, KP. Nitric oxide inhibits the expression of AT1 receptors in neurons. Am J Physiol Cell Physiol. 302(8):C1162-1173. 2012. PMID: 22218225

152. Leite, LHR, Zheng, H, Coimbra, CC, and PATEL, KP. Contribution of the paraventricular nucleus (PVN) in autonomic adjustments to heat stress. Expt Bio & Med. 237(5):570-577. 2012. PMID:22619372

153. Xu, B, Zheng, H, and PATEL, KP. Enhanced activation of RVLM projecting PVN neurons in rats with chronic heart failure. Am J Physiol Heart Circ Physiol. 302(8):H1700-1711. 2012. PMID: 22307669

154. Northcott, CA, Billecke, S., Craig T, Hinojosa-Laborde, C, PATEL, KP, Chen AF, D’Alecy L, & Haywood, JR. Nitric oxide synthase, ADMA, SDMA and nitric oxide in the paraventricular nucleus throughout the etiology of renal wrap hypertension. Am J Physiol Heart Circ Physiol. 302(11):H2276-2284. 2012. PMID: 22447945

155. PATEL, KP, and Schultz, HD. Angiotensin peptides and nitric oxide in cardiovascular disease. Antioxid Redox Signal. 19(10); 1121-32, 2012. PMID: 22462736

156. Zheng, H, Sharma, NM, Liu, X, and PATEL, KP. Exercise training normalizes enhanced sympathetic activation from the paraventricular nucleus in chronic heart failure: role of angiotensin II. Am J Physiol Reg & Integr Physiol. 303(4):R387-94. 2012. PMID: 22718804

157. Zucker, IH, PATEL, KP, and Schultz, HD. Highlighted Topic: Autonomic Regulation of Cardiovascular Function in Health and Disease: Be sympathetic to your nervous system. J Applied Physiol 113:1292-1293, 2012. PMID: 22858623

158. Haack, KK, Engler, CW, Papoutsi, E, Pipinos, II, PATEL, KP, and Zucker, IH. Parallel changes in neuronal AT1R and GRK5 expression following exercise training in heart failure. Hypertension. 60(2):354-61, 2012. PMID: 22753221

159. Leite, LHR, Sharma, NM, Bafna, S, Zheng, H, Coimbra, CC, and PATEL, KP. Construction and validation of lentiviral vector carrying rat neuronal nitric oxide synthase In vitro and In vivo. J Neurosci. Methods. 211(1):77-83. 2012. PMID:22921486

160. Zheng, MQ, Li, X, Tang, K, Sharma, NM, Wyatt, TA, PATEL, KP, Gao, L, Bidasee, KR and Rozanski, GJ. Pyruvate restores β-Adrenergic sensitivity of L-type Ca2+ channels in failing rat heart: role of protein phosphatase. Am J Physiol. Heart Circ Physiol 304(10):H1352-60, 2013. PMID: 23504177

161. Xu, B, Zheng, H and PATEL, KP. Relative contributions of the thalamus and the paraventricular nucleus of the hypothalamus in the cardiac sympathetic afferent reflex. Am J Physiol Heart Circ Physiol 305(1):R50-9, 2013. PMID:23616108

162. Wang, HJ, Wang, W, PATEL, KP, Rozanski, GJ and Zucker, IH. Spinal cord GABA receptors modulate the exercise pressor reflex in decerebrate rats. Am J Physiol Regul Integr Comp Physiol. 305(1):R42-9, 2013. PMID:23637133

163. PATEL, KP, Salgado, HC, Liu, X and Zheng, H. Exercise training normalizes blunted central component of baroreflex response in rats with heart failure: role of the PVN. Am J Physiol Heart Circ Physiol 305(2):H173-81, 2013. PMID:23686710

164. Zheng, H, Liu, X, and PATEL, KP. Centrally mediated erectile dysfunction in rats with type 1 diabetes: role of angiotensin II and superoxide. J Sexual Medicine10(9):2165-76 PMID:23841890, 2013.


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165. Son, SJ, Filosa, JA, Potapenko, ES, Biancardi, VC, Zheng, H, PATEL, KP, Tobin, VA, Ludwig, M, and Stern, JE. Dendritic peptide release mediates interpopulation crosstalk between neurosecretory and preautonomic networks. Neuron 19;78(6):1036-49. 2013. PMID: 23791197

166. Sharma, NM, Llewellyn, T, Zheng, H, and PATEL, KP. Angiotensin II - mediated post-translational modification of nNOS in the PVN of rats with CHF: Role for PIN. Am J Physiol Heart Circ Physiol 305(6):H843-55. 2013. PMID:23832698

167. Tu, H, Liu, J, Zhang, D, Zheng, H, PATEL, KP, Cornish, KG, Wang, WZ, Muelleman, RL, Li, YL. Heart failure-induced changes in voltage-gated Ca++ channels and cell excitability in rat cardiac postganglionic neurons. Am J Physiol Cell Physiol. 306(2):C132-42, 2014. PMID:24025863

168. Llewellyn, T, Sharma, NM, Zheng, H, and PATEL, KP. The effects of exercise training on SFO-mediated sympathoexcitation during chronic heart failure. Am J Physiol Heart Circ Physiol. 306(1):H121-31, 2014. PMID:24163080

169. Zheng, H, Liu, X, Li, YL, and PATEL, KP. Atenuated dopaminergic tone in the paraventricular nucleaus contributing to sympathoexcitation in rats with Type 2 diabetes. Am J Physiol. Regul Integr Comp Physiol. 306(2):R138-48, 2014. PMID:24305061

170. Han-Jun Wang HJ, Cahoon R, Edgar B. Cahoon EB, Zheng H, PATEL, KP, Zucker IH. Glutamatergic Receptor Dysfunction in Spinal Cord Contributes to the Exaggerated Exercise Pressor Reflex in Heart Failure. Am J Physiol Heart Circ Physiol. 308(5):H447-55 2015. PMID:25502111

171. Vaz G.C., Bahia APO, Müller-Ribeiro FC, Xavier CH, Patel KP, Santos RAS, Fabrício A. Moreira FA, Frézard F, Fontes MAP. Cardiovascular and behavioral effects produced by administration of liposome-entrapped GABA into the rat central nervous system. Neuroscience. 285:60-69, 2015.10.067. PMID:25446344

172. Xu B, Zheng, H, Liu, X, & PATEL KP. Activation of Afferent Renal Nerves Modulates RVLM Projecting PVN Neurons. Am J Physiol Heart Circ Physiol 308(9):H1103-11, 2015. PMID: 25637549

173. Zucker IH, Schultz, HD, PATEL KP, Wang HJ. Modulation of Angiotensin II signaling following exercise training in heart failure. Am J Physiol Heart Circ Physiol. 308(8):H781-91. 2015. PMID: 25681422

174. Katayama PL, Castania JA, Dias DP, PATEL KP, Fazan R Jr, Salgado HC. Role of Chemoreceptor Activation in Hemodynamic Responses to Electrical Stimulation of the Carotid Sinus in Conscious Rats. Hypertension. 66(3):598-603, 2015. PMID:26195479

175. Zheng, H, Liu, X, Sharma, NM, Pliquett,RU, & PATEL KP. Urinary proteolytic activation of renal epithelial Na+ channels in chronic heart failure. Hypertension 67:197-205, 2016. PMID:26628676

176. Sharma NM, Rabeler B, Zheng H, Raichlin E, and PATEL KP. (2016) Exercise Training Attenuates Upregulation of p47phox and p67phox in Hearts of Diabetic Rats. Oxid Med & Cell Longev. 2016:5868913.doi:10.1155/2016/5868913. Epub 2016 Feb 16. PMID: 26989452 [PubMed – in process]

177. Pinto TO, Lataro MR, Castania JA, Durand MT, Silva CAA, PATEL KP, Rubens Fazan R,

Helio C. Salgado HC. Electrical stimulation of the aortic depressor nerve in conscious rats overcomes the attenuation of the baroreflex in chronic heart failure. Am J Physiol Reg & Integrative 310(7):R612-8. 2016. PMID:26843582

178. PATEL KP, Xu B, Liu X, Sharma NM, Zheng, H. Renal denervation improves exaggerated symptho-excitation in rats with heart failure: Role for nNOS in the paraventricular nucleus. Hypertension 68(1):175-84. 2016. PMID:27185748

179. Mahata SK, Zheng H, Mahata S, Liu X and PATEL KP. Effect of Heart Failure on

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Catecholamine Granule Morphology and Storage in Chromaffin Cells. J. Endocrinology 230:1-15, 2016. PMID:27402067

180. Zheng, H, Liu X, Sharma, NM, & PATEL KP. Renal denervation improves cardiac function

in rats with heart failure: effects on expression of -adrenoceptors. Am J Physiol Heart Circ Physiol 311(2):H337-46. 2016. PMID:27288440

181. Nandi SS, Zheng, H, Sharma, NM, Shahshahan HR, PATEL KP and Mishra PK. Lack of miR-133a decreases contractility in diabetic hearts: a role for novel cross-talk between tyrosine aminotransferase and tyrosine hyrdroxylase. Diabetes 65(10):3075-90. 2016 PMID:27411382

182. Stern JE, Son SJ, Biancardi VC, Zheng H, Sharma NM and PATEL KP. Astrocytes contribute to Angiotensin II stimulatory actions on hypothalamic presympathetic neuronal activity and sympathetic activity. Hypertension 68(6):1483-1493. 2016 PMID:27698069

183. Sharma NM, Cunningham CJ, Zheng, H, Liu X and PATEL KP. HIF-1 alpha mediates increased sympthoexcitation via glutamatergic NMDA receptors in the PVN of rats with heart failure. Circulation: Heart Failure. Nov;9(11). 2016 PMID:27810863

184. Vas GC, Sharma NM, Zheng, H, Zimmerman MC, Santos RS, Frezard F, Fontes MAP and PATEL KP. Liposome-entrapped GABA modulates the expression of nNOS in NG108-15 cells. J Neuroscience Methods 273:55-63. 2016. PMID:27523033

185. Sharma NM, and PATEL KP. Post-translational Regulation of Neuronal Nitric Oxide Synthase: Implications for sympatho-excitatory states. Expert Opin. on Ther. Targets 21(1):11-22. 2017 PMID:27885874

186. Zheng, H, and PATEL KP. Integration of renal sensory afferents at the level of the paraventricular nucleus dictating sympathetic outflow. Autonomic Neuroscience: Basic and

Clinical S1566-0702(16)30131-X. (Invited Review) 2017. PMID:27527558 PMC 5293680

187. Sharma NM, Nandi SS, Zheng, H, Mishra PK, and PATEL KP. A novel role for miR-133a in centrally mediated activation of the Renin-angiotensin system in congestive heart failure. Am J Physiol Heart Circ Physiol. 312(5):H968-H979, 2017. PMID:28283551

188. Mishra PK, Ying W, Nandi SS, Bandyopadhyay, GK, PATEL KP & Mahata SK. Diabetic cardiomyopathy: an immunometabolic perspective. Frontiers in Endocrinology 8:72.doi:103389/fendo.2017. PMID:28439258

189. Zheng, H, Liu X, Li,Y, and PATEL KP. A hypothalamic Leptin-Glutamate interaction in the regulation of sympathetic nerve activity. Neural Plasticity Volume 2017, Article ID 2361675, https://doi.org/10.1155/2017/2361675, 2017. PMID:28845307

190. Articles In Press/In revision/In preparation – 1.


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Books, Book Chapters, Review Articles, Letter and Editorials – 1. Schmid, PG, & PATEL, KP. Cardiovascular effects of neurohypophysial peptides. The

Peptides 8:335-362. 1986. 2. PATEL, KP, & Schmid, PG. The role of central noradrenergic pathways in the actions of

vasopressin on baroreflex control of the circulation. In: Brain Peptides and Catecholamines in Cardiovascular Regulation in Normal and Disease States. Ed. J.P. Buckley and C.M. Ferrario. Raven Press, New York, pp. 53-64. 1987.

3. Schmid, PG, & PATEL, KP. Role of the forebrain in the influence of vasopressin on cardiovascular reflexes. In: Vasopressin. Ed. A. W. Cowley. Raven Press, New York. pp, 427-432, 1988.

4. Zucker, IH, Wang, W, Brandle, M, Schultz, HD, & PATEL, KP. Neural regulation of sympathetic nerve activity in heart failure. Prog. Card. Dis. 37: 397-414, 1995.

5. PATEL, KP. Volume reflex in diabetes. Cardiovascular Res.34:81-90, 1997. 6. PATEL, KP. Neural regulation in experimental heart failure. In: Neurocardiology. Ed. D.

Cechetto and V.Hachinski. W.B. Saunders, London, pp. 283-296. 1998. 7. PATEL, KP. Role of paraventricular nucleus in mediating sympathetic outflow in heart

failure. Heart Failure Reviews 5:73-86, 2000. 8. Zucker, IH, Wang, W, Pliquett, RU, Liu, JL, Irvine, S, & PATEL, KP. The regulation of

sympathetic outflow in heart failure: the role of Angiotensin II, nitric oxide and exercise training. Ann. New York Academy Sci. 940:431-443, 2001.

9. PATEL, KP, Li, Y-F, & Hirooka, Y. The role of nitric oxide on central sympathetic outflow. Proc Soc Exp Bio Med. 226(9):814-824, 2001. (Invited review).

10. Li, Y-F, Zhang, K, Mayhan, WG, & PATEL, KP. Blunted inhibition of renal sympathetic nerve activity discharge induced by clonidine in rats with heart failure. In: Advances in Heart Failure. Ed. A. Kimchi MEDIMOND Inc., Monduzzi Editore, Bologna, Italy, pp. 77-86, 2002.

11. Mueller, PJ, Cunningham, JTH, PATEL, KP, & Hasser, EM. Proposed role of paraventricular nucleus in cardiovascular deconditioning. Acta. Physiol. Scand. 177(1):27-35, 2003.

12. Li, Y-F, & PATEL, KP. Paraventricular nucleus of the hypothalamus and elevated sympathetic

activity in heart failure: the altered inhibitory mechanisms. Acta. Physiol. Scand. 177(1):17-26, 2003.

13. Weiss, ML, Kenney, MJ, Musch, TI, & PATEL, KP. Modifications to central neural circuitry during heart failure. Acta Physiol Scand. 177(1):57-67, 2003.

14. Zucker, IH, PATEL, KP, Schultz, HD, Li, YF, Wang, W, & Pliquett, RU. Exercise training and

sympathetic regulation in experimental heart failure. Exerc Sport Sci Rev.32:107-111, 2004. 15. Li, Y-F, Wang, Y, Channon KM, Schultz, HD, Zucker, IH, & PATEL, KP. Manipulation of

neuronal nitric oxide synthase within the paraventricular nucleus using adenovirus and antisense technology. Methods in Molecular Medicine 112:59-79, 2005.

16. Zucker, IH, PATEL, KP, & Schultz, HD. Neurohumoral Stimulation. Heart Fail Clin. 8(1):87-99. 2012.

17. Zucker, IH, PATEL, KP, and Schultz, HD. Highlighted Topic: Autonomic Regulation of Cardiovascular Function in Health and Disease: Be sympathetic to your nervous system. J Applied Physiol 113:1292-1293, 2012. PMID: 22858623

18. PATEL, KP, and Schultz, HD. Angiotensin peptides and nitric oxide in cardiovascular disease. Antioxid Redox Signal. 19(10); 1121-32, 2012. PMID: 22462736

19. Zucker IH, Lindsey ML, Delmar M, De Windt LJ, Des Rosiers C, Diz DI, Hester RL, Jones SP,

Kanagy NL, Kitakaze M, Liao R, Lopaschuk GD, Patel KP, Recchia FA, Sadoshima J, Shah AM,

Ungvari ZI, Benjamin IJ, Blaustein MP, Charkoudian N, Efimov IR, Gutterman DD, Kass DA, Liao Y, O'Leary DS, Ripplinger CM, Wolin MS. Why Publish in the American Journal of Physiology-Heart

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and Circulatory Physiology? Am J Physiol Heart Circ Physiol. 313(2):H221-H223, 2017.

PMID:28626081

Abstracts Published 1. PATEL, KP, Ciriello, J. & Kline, RL. Aortic depressor nerve (AND) transection increases

norepinephrine (NE) turnover in brain and peripheral organs in the rat. Fed. Proc. 64:962, 1980.

2. PATEL, KP, Kline, RL, & Mercer, PF. Norepinephrine concentration (NE) in kidney and intestine or normotensive and spontaneously hypertensive rats (SHR) at various ages. Proc Can. Fed. Biol. Soc. 23:102, 1980.

3. PATEL, KP, Kline, RL. & Mercer, PF. Turnover of norepinephrine (NE) in brain and peripheral organs of spontaneously hypertensive rats (SHR) and normotensive rats. The Physiologist 23:92, 1980.

4. PATEL, KP, Kline, RL. & Mercer, PF. Renal denervation prevents the noradrenergic response to aortic depressor nerve (AND) transection in rats. Proc. Can. Fed. Biol. Soc. 24:186, 1981.

5. PATEL, KP, & Kline, RL. Turnover of NE in brain and peripheral organs of conscious rats subject to hypotension. Pharmacologist 24:234, 1982.

6. PATEL, KP, & Kline, RL. Is the turnover of norepinephrine in the heart a useful index of general sympathetic activity to the cardiovascular system? Soc. Neuroscience 8: 722, 1982.

7. PATEL, KP, Kline, RL, & Mercer, PF. Interaction between baroreceptor and renal afferent information at the level of the hypothalamus as measured by changes in noradrenergic activity. Fed. Proc. 42:481, 1983.

8. Kline, RL, PATEL, KP, & Mercer, PF. Evidence that afferent renal nerves (ARN) are not involved in the effect of renal denervation in spontaneously hypertensive rats (SHR). Fed. Proc. 42:743, 1983.

9. Kline, RL, Ciriello, J. PATEL, KP, & Mercer, PF. Lesions of paraventricular nucleus (PVH) decreases norepinephrine (NE) turnover in the kidney of SHR. 29th Int. Congress Physiol. Sci., 1983.

10. PATEL, KP, & Kline, RL. Renal nerve-dependent dopaminergic activity in the hypothalamus in the rat. Soc. Neuroscience 9:105, 1983.

11. PATEL, KP, Kline, RL, and Mercer, PF. Selective activation of renal nerves in diabetes insipidus (DI) rats. Fed. Proc. 43:724, 1984.

12. Kline, RL, PATEL, KP, & Mercer, PF. Decrease in peripheral sympathetic activity of diabetes insipidus (DI) rats after vasopressin replacement. Fed. Proc. 43:724, 1984.

13. Mercer, PF, PATEL, KP, & Kline, RL. Selective activation of renal nerves during furosemide-induced natriuresis and diuresis. Fed. Proc. 43:1067, 1984.

14. Pardini, BJ, PATEL, KP, Schmid, PG, & Lund, DD. Location and distribution of parasympathetic ganglion cells in the rat heart. Soc. Neuroscience 10:607, 1984.

15. Pardini, BJ, PATEL, KP, Lund, DD, & Schmid, PG. Facilitation of reflex bradycardia by hypothalamic stimulation in rats. Fed. Proc. 44:1028, 1985.

16. Brown, DR, Peuler, JD, PATEL, KP, Thoren, P, & Mark, A. 24 hour mean arterial pressure profiles in aortic baroreflex denervated and control rats. Fed. Proc. 44:629,1985.

17. Peuler, JD, PATEL, KP, Lund, DD, Pardini, BJ, & Schmid, PG. Selective increase in renal and cardiac noradrenergic activity in Dahl salt-sensitive rats. Fed. Proc. 44:1278,1985.

18. PATEL, KP, Whiteis, CA, Lund, DD, & Schmid, PG. Contrasting effects of vasopressin (AVP) and angiotensin II (AII) infusions (IV) on regional norepinephrine (NE) turnover in conscious rabbits. Fed. Proc. 44:1347, 1985.

19. PATEL, KP, Whiteis, CA, Lund, DD, & Schmid, PG. Contrasting central noradrenergic responses to acute intravenous infusions of vasopressin and angiotensin in conscious

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rabbits. Sixth Sci. Sessions of Inter-American Soc. of Hypertension 1985.

20. Schmid, PG, PATEL, KP, Whiteis, CA, & Lund, DD. The effects of vasopressin on central and peripheral noradrenergic activity in conscious rabbits. Am. Soc. Clin. Invest. Res. 33:522A, 1985

21. PATEL, KP, Peuler, JD, Whiteis, CA, Pardini, BJ, Lund, DD. & Schmid, PG. Altered noradrenergic activity in specific hypothalamic areas of the Dahl salt-sensitive rats. Soc. Neurosci. 11:996,1985.

22. PATEL, KP, & Schmid, P.G. Role of paraventricular nucleus (PVN) in baroreflex mediated changes in lumbar sympathetic nerve activity and heart rate. Fed. Proc. 45: 391, 1986.

23. Peuler, JD, PATEL, KP, Morgan, DA, Pardini, BJ, Lund, DD, & Schmid, PG. Sinoaortic denervation selectively abolishes differences in norepinephrine (NE) turnover between Dahl salt-sensitive (S) and salt-resistant (R) rats in cardiac atria and spleen but not cardiac ventricles and renal cortex. Fed. Proc. 45: 876, 1986.

24. PATEL, KP, & Schmid, PG. The role of median preoptic nucleus (MPO) in vasopressin mediated bradycardia. Soc. Neurosci. 12: 1986.

25. Wilkin, LD, PATEL, KP, Schmid, PG, and Johnson, AK. Central changes in norepinephrine turnover in response to reduced extracellular fluid volume. Soc. Neurosci. 12: 1986.

26. PATEL, KP, & Schmid, PG. Vasopressin inhibits sympathetic ganglionic transmission but potentiates sympathetic neuroeffector responses in hindlimb vasculature of rabbits. Soc. Neurosci. 13: 1987.

27. Zeigler, DW, Adajar, RV, & PATEL, KP. Role of renal nerves in the diuresis and natriuresis produced by central administration of clonidine. FASEB Journal 2:A1319, 1988.

28. PATEL, KP, & Zeigler, DW. Atrial natriuretic factor attenuates sympathetic neuroeffector responses in hindlimb vasculature of rabbits. FASEB Journal 2: 1988.

29. PATEL, KP. Role of central alpha-2 adrenergic mechanisms in the renal nerve mediated natriuresis and diuresis produced by acute volume expansion. Soc. Neurosci. 14:973, 1988.

30. PATEL, KP. & Zhang, PL. Reduced diuresis and natriuresis in response to volume expansion in streptozotocin induced diabetic rats. FASEB Journal 3:A1000, 1989.

31. Zeigler, DW, & PATEL, KP. Effect of bilateral renal denervation on the renal actions of atrial natriuretic peptide. FASEB Journal 3: A246, 1989.

32. Krukoff, TL. & PATEL, KP. Metabolic alterations in rat brain associated with streptozotocin-induced diabetic mellitus. Soc. Neuro. 15:662, 1989.

33. PATEL, KP. Vagal mediation of diuresis and natriuresis by atrial natriuretic factor in rats. FASEB Journal 4:A430, 1990.

34. Zhang, PL. & PATEL, KP. Attenuated renal responses to atrial natriuretic factor in streptozotocin induced diabetic rats. FASEB Journal 4:A430, 1990.

35. Zeigler, DW. & PATEL, KP. Altered renal responses to acute volume expansion in hypertensive obese Zucker rats. FASEB Journal 4:A565, 1990.

36. Zhang, PL, & PATEL, KP. Decreased diuretic and natriuretic responses to volume expansion in diabetic rats. FASEB Journal 5:A911, 1991.

37. Hein, MS, Schlenker, EH, & PATEL, KP. Altered control of ventilation in streptozotocin-induced diabetic rats. FASEB Journal 5:A1477, 1991.

38. Zeigler, DW. & PATEL, K.P. Importance of renal nerves in the renal responses to ANP in DOCA-SALT hypertensive rats. FASEB Journal 5:A1483, 1991

39. PATEL, KP, & Zhang, PL. Renal responses to acute volume expansion (VE) in rats with coronary occlusion. FASEB Journal 5:A737, 1991.

40. Zhang, PL, & PATEL, KP. Role of renal sympathetic nerve activity in blunted volume reflex in streptozotocin-induced diabetic rats. Physiologist: 1991

41. PATEL, KP. A Mathematical model to assess changes in the neural component of the


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volume reflex in rats with myocardial infarct. FASEB Journal 6:A1777 1992.

42. PATEL, KP. and Jeffries, WB. Alpha-1B adrenoceptor blockade corrects the blunted diuresis and natriuresis in response to volume expansion (VE) in streptozotocin (STZ) induced diabetic rats. FASEB Journal 7:A6, 1993.

43. Zucker, IH, Wang, W, Brandle, M, & PATEL, KP. Hemodynamic and norepinephrine responses to pacing-induced heart failure in conscious intact and sino-aortic denervated dogs. FASEB Journal 7:A532, 1993.

44. Jeffries, WB. & PATEL, KP. Chloroethyleclonidine (CEC) enhances natriuresis and diuresis during acute volume expansion. FASEB Journal 7:A189, 1993.

45. Haselton, JR, Goering, JD, & PATEL, KP. Chronic kainic acid lesions in the paraventricular nucleus (PVN) of the hypothalamus attenuate the reflex renal sympatho-inhibition during acute volume expansion (VE) in rats. Soc. Neurosci. 19:319, 1993.

46. PATEL, KP. Renal interstitial hydrostatic pressure (RIHP) and sodium excretion during acute volume expansion (VE) in streptozotocin (STZ) induced diabetic rats. FASEB Journal 8: A587, 1994.

47. PATEL, KP. Origins of sympathetic nerve activity in heart failure. 3rd International Congress on Heart Failure - Mechanisms and Management: 1995.

48. Fitch, GK., PATEL, KP. & Weiss, ML. C-fos immunocytochemical labeling within the rat dorsal horn after renal afferent stimulation. Soc. Neurosci. 21: 1995.

49. Ikenaga, H, Fallet, RW, Cornish, KG, PATEL, KP. & Carmines, PK. Enhanced afferent arteriolar vasoconstrictor responses to angiotensin II after myocardial infarction reflects a diminished modulatory impact of nitric oxide. J. Am. Soc. Nephrol. 6:660, 1995.

50. Zhang, K, Mayhan WG, & PATEL, KP. Effect of nitric oxide in the paraventricular nucleus on renal nerve discharge. FASEB Journal 9:A595.1, 1996.

51. PATEL, KP. & Zhang, K. Blunted endogenous GABA-mediated inhibition in the paraventricular nucleus on renal nerve discharge in rats with heart failure. FASEB Journal 9:A595.2, 1996.

52. PATEL, KP, Zhang, K, & Zucker, IH. Role of forebrain in the increase in sympathetic nerve activity in heart failure. Journal of Heart Failure 3:78, 1996.

53. Xu, Z, PATEL, KP, & Rozanski, GJ. Enhancing glucose oxidation in vitro restores

depressed transient outward K+ current (Ito) in ventricular myocytes from diabetic rats.

FASEB Journal 10:A495, 1997. 54. Zucker, IH, Wang, W, Liu, J-L, PATEL, KP, & Schultz, HD. Multiple mechanisms for the

regulation of sympathetic outflow in chronic experimental heart failure. J. Mol. & Cellular Cardio. 29:A249, 1997.

55. Zhang, K, & PATEL, KP. Effect of heart failure on NADPH diaphorase positive neurons in the hypothalamus of rats. FASEB Journal 10:A49, 1997.

56. PATEL, KP. & Zhang, K, Role of paraventricular nucleus in the altered sympathetic nerve activity in heart failure. 5th International Congress on Heart Failure. 1997.

57. Zhang, K, & PATEL, KP. Effect of nitric oxide within the paraventricular nucleus on renal sympathetic nerve discharge: Role of GABA. Am. Physiol. Soc. Confer. 1998.

58. Kenney, MJ, PATEL, KP, & Weiss, ML. Role of PVN in the sympathetic response to increased body temperature in a rat heart failure model. Am. Physiol. Soc. Confer. 1998.

59. PATEL, KP, & Carmines, PK. Diminished renal interstitial hydrostatic pressure and medullary blood flow responses to acute volume expansion in diabetic rats. FASEB Journal 13:A375.1,1999.

60. Haywood, JR, Hinojosa-Laborde, C, Craig, T, & PATEL, KP. NADPH-diaphorase positive neurons are reduced in the paraventricular nucleus in renal wrap hypertension. FASEB Journal 13:A605.9,1999.


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61. PATEL, KP. & Zhang, Y-M. Role of nitric oxide within the paraventricular nucleus on renal sympatho-inhibition elicited by acute volume expansion. Soc. Neurosci. 25:1956, 1999.

62. Kenny, MJ, Weiss, ML, PATEL, KP, & Fels, RJ. Microinjection of bicuculline within the paraventricular nucleus (PVN) alters the frequency components of sympathetic nerve discharge bursts. Soc. Neurosci. 25:1955, 1999.

63. Li, Y-F, & PATEL, KP. Effect of NMDA within the paraventricular nucleus on renal sympathetic nerve discharge is moderated by an NO mechanism. FASEB Journal 14:A66, 2000.

64. Maier, J, Carmines, PK, & PATEL, KP. Exercise training improves urine flow and sodium excretory responses to acute volume expansion in diabetic rats. FASEB Journal 14:A671, 2000.

65. Zucker, IH, PATEL, KP, & Liu, J-L. Exercise training normalizes central nitric oxide synthase activity in rabbits with chronic heart failure: Relation to sympathetic tone. Am Heart Assoc. 2000.

66. Skorupa, JY, Li, Yi-Fan, Maier, J, Zucker, IH, Carmines, PK, & PATEL, K.P. Exercise training improves the volume reflex in rats with heart failure. Soc. Neurosci. 26:1947, 2000.

67. Li, Y-F, Vollmer, A, Maier, S, and PATEL, KP. Potentiated NMDA-mediated increases in RSND within the paraventricular nucleus of rats with heart failure (HF). Soc. Neurosci 26:1946, 2000.

68. Cornish, KG, Hughes, K, & PATEL, KP. The effect of volume maintenance on deconditioning effects of simulated microgravity in non-human primate. FASEB Journal 15:A1111, 2001.

69. Li, Y-F, & PATEL, KP. Effect of angiotensin II (AII) within the paraventricular nucleus on renal sympathetic nerve discharge is moderated by an NO mechanism. FASEB Journal 15:A806, 2001.

70. Huang, J, PATEL, KP, & Weiss, ML. Neural circuitry of the kidney: a pseudorabies virus tracing study following guanathidine chemical sympathectomy. FASEB Journal 15:A802, 2001.

71. Zhu, G, PATEL, KP, Zucker, IH, & Wang, W. Central effects of angiotensin II on cardiac sympathetic afferent reflex in chronic heart failure. FASEB Journal 15:A469, 2001.

72. PATEL, KP, Cornish, K, Li, & Y-F. Enhanced NMDA receptors within the paraventricular nucleus of rats with heart failure (HF). IUPS, 2001.

73. Li, Y-F, Cornish, K, & PATEL, KP. Enhanced NMDA receptor function within the paraventricular nucleus of rats with heart failure (HF). FASEB Journal 16:A504, 2002.

74. Zheng, H., Li, Y-F, & PATEL, KP. Exercise training improves endogenous nitric oxide mechanisms within the PVN involved in regulating renal sympathetic nerve activity in rats with heart failure (HF). FASEB Journal 16:A504, 2002.

75. Wang, Y, PATEL, KP, Cornish, K, & Zucker, IH. nNOS gene transfer in RVLM improves baroreflex function in rats with heart failure. FASEB Journal 16:A501, 2002.

76. Wang, W, Zhu, G, PATEL, KP, & Zucker, IH. AT1 receptor mRNA antisense normalizes enhanced cardiac sympathetic afferent reflex in rats with heart failure. FASEB Journal 16:A830, 2002.

77. Heesch, CM, Zheng, H, & PATEL, KP. Decreased NADPH-diaphorase (nNOS) positive neurons in the paraventricular nucleus of the hypothalamus in pregnant rats. FASEB Journal 16:A501, 2002.

78. Mueller, PJ, Cunningham, JT, Zheng, H, PATEL, KP, & Hasser, EM. NADPH-diaphorase positive neurons in the hypothalamus of hindlimb unweighted rats. FASEB Journal 16:A502, 2002.

79. DiCarlo, SE, Zheng, H, Collins, HL, Rodenbaugh, DW, & PATEL, KP. Daily exercise normalizes the number of diaphorase (NOS) positive neurons in the hypothalamus of hypertensive rats. Am. Col. Sport Med. 49:A50, 2002.


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80. PATEL, KP. Role of paraventricular nucleus in mediating sympathetic outflow in heart failure. FASEB Journal 17:A504, 2003.

81. Li, Y-F, Cornish, K, & PATEL, KP. The role of NO in enhanced AT1 receptor function within the paraventricular nucleus of rats with heart failure. FASEB Journal 17: 2003.

82. Zheng, H., Li, Y-F, & PATEL, KP. Exercise training improves endogenous nitric oxide mechanisms within the PVN involved in regulating renal sympathetic nerve activity in rats with diabetes. FASEB Journal 17: 2003.

83. Rabeler, B, Li, Y-F, & PATEL, KP. Paraventricular nucleus mediated sympathetic outflow: Role of glutamate and GABA systems. FASEB Journal 17:A504, 2003.

84. Zheng, H, Li, Y-F, Liu, X, & PATEL, KP. Reduced endogenous GABA-mediated inhibition in the paraventricular nucleus on renal sympathetic nerve acitivity in rats with diabetes. FASEB Journal 18: A668, 2004.

85. Guo, L, Schultz, HD, PATEL, KP, Zucker, IH. & Wang, W. Cardiac sympathetic afferent stimulation augments the arterial chemoreceptor reflex in normal rats. FASEB Journal 18:A669, 2004.

86. Li, Y-L, Li, Y-F, Wang, W, Cornish, KG, PATEL, KP, Zucker, IH, & Schultz, HD. Attenuation of chemoreceptor sensitivity by transfection of Ad,nNOS in carotid body of heart failhre rabbits. FASEB Journal 18:A1277, 2004.

87. Guo, L, Wang, W, Schultz, HD, PATEL, KP, & Zucker, IH. Oxidative stress mediates the effects of central angiotensin II on baroreflex function in conscious rats with heart failure. FASEB Journal 18:A1258, 2004.

88. Li, Y-F, Vollmer, A, Rebeller, B, & PATEL, KP. Inhibitory effect of NO on AT1 receptor expression in neuronal cells. FASEB Journal 18:A1264, 2004.

89. Li, Y-L, Li, Y, Wang, W, Cornish, KG, PATEL, KP, Zucker, IH, & Schultz, HD. Effect of AdnNOS tranfection on outward potassium currents in carotid body glomus cells form heart failure rabbits. FASEB Journal 18:A1277, 2004.

90. Zheng, H, Liu, X, & PATEL, KP. Potentiated angiotensin-mediated excitation of renal nerve activity within the paraventricular nucleus of rats with diabetes. FASEB Journal 19:A1290 2005.

91. Liu, Y-L. Zhang, H, Li, Y-F, PATEL, KP, & Schultz, HD. Involvement of superoxide production on angiotensin II blunted outward K+ current on NG 108-15 cells. FASEB Journal 19:A1292 2005.

92. Liu, Y-L, Zhang, H, Li, Y-F, PATEL, KP, & Schultz, HD. Angiotensin II-superoxide signaling pathway potentiates the sensitivity of outward K+ channels to hypoxia in carotid body and NG 108-15 cells. FASEB Journal 19:A1291 2005.

93. Zheng, H, Liu, X, Kleiber, A, Davisson RL, & PATEL, KP. Angiotensin II-mediated sympathoexcitation in diabetes: Role of superoxide. FASEB Journal 20:C456, 2006.

94. Kleiber A, Zheng, H, Liu, X, & PATEL, KP. Exercise training normalizes NMDA-mediated changes in renal sympathetic nerve activity and NR1 expression within the PVN in heart failure rats. FASEB Journal 20:C434, 2006.

95. Shao, CH, PATEL, KP, & Bidasee, KR. Exercise training blunt RyR2 dysfunction in hearts of streptozotocin-induced diabetic rats. Biophys. J. 90 (2), B317 (P2949), 2007.

96. Shao, CH, PATEL, KP, & Bidasee, KR. Carbonylation contributes to RyR2 dysregulation during Type 1 diabetes. Biophys. J. 90 (2), B313 (P2953), 2007.

97. Guggilam, A, Haque M, Ebenezer P, PATEL, KP, & Francis J. Chronic tumor necrosis Factor-alpha induces sympathoexcitation by modulating nitric oxide synthase in rats. FASEB Journal 21: 582.41, 2007.

98. Zheng, H, Liu, X, Kleiber, A, & PATEL, KP. Gene transfer of neuronal nitric oxide synthase to the paraventricular nucleus improves enhanced NMDA NR1 receptor function in rats with chronic heart failure. FASEB Journal 21:910.5, 2007.


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99. Kleiber A, Zheng, H, & PATEL, KP. Chronic AT1 receptor blockade normalizes NR1 expression within the paraventricular nucleus (PVN) in rats with heart failure (HF). FASEB Journal 21:910.6, 2007.

100. Zheng, H, Liu, X, & PATEL, KP. Exercise training improves central NMDA-induced erectile dysfunction in diabetes. FASEB Journal 21: XXX, 2008.

101. Kleiber A, Zheng, H, & PATEL, KP. Chronic AT1 receptor blockade normalizes NMDA-mediated changes in renal sympathetic nerve activity from the paraventricular nucleus (PVN) in heart failure (HF). FASEB Journal 22:952.12, 2008.

102. Zheng, H., Liu, X,Rao, US. & PATEL, KP. Contribution of renal epithelial sodium channel in sodium retention during chronic heart failure. FASEB Journal 22:1159.18, 2008.

103. Huang, BS, Zheng, H, PATEL, KP, & Leenen, HH. Central infusion of aldosterone induces a decreased nNOS and increased AT1R and components of NADPH oxidase within the PVN. High Blood Pressure Council: 2008.

104. Zheng H, Liu XF & PATEL, KP. Altered noradrenergic-mediated sympathetic activation in the paraventricular nucleus of rats with chronic heart failure. Abstract in Society for Neuroscience Meeting, Chicago, 2009

105. Zheng H, Liu XF, Moser JS, & PATEL, KP. Gene transfer of angiotensin converting enzyme 2 to the paraventricular nucleus improves attenuated nitric oxide mechanism in rats with chronic heart failure. FASEB Journal 2009 23:956.2

106. Leite LH, Zheng H, Coimbra CC, & PATEL, KP. Enhanced heat loss despite blunted renal sympathoexcitation in diabetic rats during heat stress. FASEB Journal 2009 23:788.3

107. Guimaraes JB, Rezende BA, Lima DC, Rodovalho GV, PATEL, KP, & Lemos VS, Coimbra CC. Exercise training improves heat balance during exercise depending on tail vasodilatation mediated by modification in vascular reactivity. FASEB Journal 2009 23: 955.34

108. Leite LHR, Zheng H, Coimbra CC, & PATEL, KP, Contribution of the paraventricular nucleus in the heat stress-induced cardiovascular adjustments. FASEB Journal 24: 992.3, 2010.

109. Zheng H, Liu X, & PATEL, KP. Enhanced activation of the median pre-optic nucleus contributes to the activation of the paraventricular nucleus in heart failure. FASEB Journal 24: 1019.14, 2010.

110. Shama N, Zheng H, Li Y-F, & PATEL, KP. Increased expression of CAPON (Carboxy-terminal PDZ ligand of nNOS) within the paraventricular nucleus (PVN) of rats with heart failure (HF). FASEB Journal 24: 1019.4, 2010.

111. Shama N, Zheng H, Llewellyn T, & PATEL, KP. Neuronal Nitric Oxide Synthase Expression in the PVN of Rats with CHF: Activation vs. Degradation FASEB J 25:843.9, 2011.

112. Llewellyn T, Zheng H, Liu X, Xu B, & PATEL, KP. Median preoptic nucleus and subfornical organ drive renal sympathetic nerve activity via a glutamatergic mechanism within the PVN FASEB J 25:651.12, 2011.

113. Xu B, Zheng H. & PATEL, KP. Altered Activation of RVLM Projecting PVN Neurons to Osmotic and Baroreceptor Challenges in Rats with Chronic Heart Failure FASEB J 25:845.3, 201.1

114. Zheng H, Liu X, & PATEL, KP. A Role for Dopamine in the Centrally Mediated Sympathetic Response in Rats with Type 2 Diabetes Induced by Streptozotocin and a High-fat Diet FASEB J 25:1028.11, 2011.

115. Zheng H, Liu XF & PATEL, KP. Central Leptin-glutamate signaling contributes to the exaggerated sympatho-excitation in rats with type 2 diabetes. FASEB J, 2012 26:705.2

116. Llewellyn TL, Sharma NM, Zheng H, & PATEL, KP. Activated subfornical organ contributes to enhanced sympathoexcitation during chronic heart failure. FASEB J, 2012 26:703.16


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117. Xu B, Zheng H & PATEL, KP. Blunted responses of renal sympathetic nerve Activity to C-type natriuretic peptide in the PVN of rats with heart failure. FASEB J, 2012 26:1091.64

118. Sharma NM, Llewellyn TL, Zheng H & PATEL, KP. Contribution of PIN in the regulation of neuronal nitric oxide synthase in the PVN of Rats with chronic heart failure. FASEB J, 2012 26:703.17

119. Son SJ, Filosa JA, Zheng H, PATEL, KP & Stern JE. Dendritic release of VP mediates crosstalk between neuroendocrine and presympathetic PVN neurons: Role in osmotically-driven homeostatic responses. FASEB, 2012 26:1091.30

120. Wang HJ, PATEL, KP, Zucker IH & Wang W. Spinal cord GABA receptors Inhibit the exercise pressor reflex in decerebrate Rats. FASEB J, 2012 26:1087.6

121. Zheng H, Liu XF, Li YL, Sharma NM and Patel KP. Enhanced levels of proteases in tubular fluid activate ENaC in chronic heart failure. FASEB J April 9, 2013 27:698.2

122. Xu B, Zheng, H and Patel KP. Afferent renal nerve stimulation excites RVLM projecting PVN neurons in rats. FASEB J April 9, 2013 27:697.3

123. Llewellyn TL, Zheng H, Sharma NM and Patel KP. Exercise training normalizes subfornical organ (SFO)-mediated sympathoexcitation in chronic heart failure (HF). FASEB J April 9, 2013 27:699.14

124. Sharma NM, Cunningham CJ, Liu XF and PATEL KP. HIF-1α Increases glutamatergic NMDA receptors in the PVN during chronic heart failure. FASEB J April 9, 2013 27:1135.14

125. Vaz GC, Sharma NM, Zheng H, Bahia APO, Zimmerman MC, Frezard F, Marco A.P. Fontes MAP & PATEL KP. Effect of Liposome Entrapped-GABA on the Expression of nNOS and GABAA Receptors in neurons. FASEB J, 28:1130.11, 2014

126. Zheng H, Liu X, Li Y, and PATEL KP. Enhanced leptin-TRPC signaling in the hypothalamus contributes to the exaggerated sympatho-excitation in type 2 diabetic rats. FASEB J 2014.

127. Nandi SS, Liu X, Zheng H, Sharma NM, PATEL KP and Mishra PK. MiR-133a Ameliorates Cardiac Dysfunction in Diabetes: Possibly by Restoring β-Adrenergic Receptor Function and Expression. FASEB J, 28:1078.06, 2014.

128. Sharma NM, Cunningham CJ, Liu X, Zheng H, & PATEL KP. HIF-1α Increases Sympathoexcitation via Upregulation of NMDA Receptors in the PVN during Heart Failure. FASEB J, 28:1130.16, 2014.

129. PATEL KP, Liu X, Llewellyn TL, and Zheng H. Renal Denervation Attenuates the Enhanced Activation of the Paraventricular Nucleus in Heart Failure: Restoring nNOS! FASEB J 2014

130. Sharma NM, Liu X, Zheng H, and PATEL KP. Altered ubiquitination and stability of protein inhibitor of neuronal nitric oxide synthase in the paraventricular nucleus of Chronic heart failure rats: Role of Angiotensin II. Circulation 130 (Suppl 2), A15532-15532, 2014.

131. Sharma NM, Liu X, Zheng H, and PATEL KP. Exercise Training restores dimeric nNOS by regulating PIN expression in the Paraventricular Nucleus of Chronic Heart Failure Rats. Circulation 132 (Suppl 3), A17215-17215, 2015.

132. Sharma NM, Nandi SS, Zheng H, Mishra PK and PATEL KP. Upregulation of Angiotensinogen (AGT) in the Paraventricular Nucleus (PVN) of the Hypothalamus during Chronic Heart Failure (CHF)-Role of miR-133a. Current Research: Cardiology, 2: 122., 2015.

133. Sharma NM, Zheng H, Liu X, and PATEL KP. Angiotensin II regulates CAPON expression via ERK-MAPK-CREB pathway In The Paraventricular Nucleus Of Chronic Heart Failure Rats. FASEB J, 29:987.7 , 2015.

134. Sharma NM, Nandi SS, Zheng H, Mishra PK, and PATEL KP. Reduced miR-133a results in Upregulation of Angiotensinogen (AGT) in the Paraventricular Nucleus (PVN) of rats with Chronic Heart Failure (CHF). FASEB J, 29:829.2, 2015.


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135. Zheng H, Liu X, Sharma NM and PATEL KP. Enhanced levels of Proteases in Tubular Fluid Activate ENaC in Chronic Heart Failure: Roles for Renal Nerves and Renal Injury. ). FASEB J, 29:829.1, 2015.

136. Zheng H, Fleecs J, Liu X, and Patel KP. Enhanced expression of renal AQP2 and ENaC in rats with chronic heart failure: a role for renal nerves FASEB J April 2016 30:1005.4

137. Haibara AS, Sharma NM, and Patel KP. Hypoxia-Inducible Factor (HIF)-1 Alpha Expression Induced by Proinflammatory Cytokines in NG108-15 Neuronal Cells FASEB J April 2016 30:1234.3

138. Sharma NM, Liu X, Zheng H, and Patel KP. Regulation of Protein Inhibitor of Neuronal Nitric Oxide Synthase in the Paraventricular Nucleus during Chronic Heart Failure: Role for Angiotensin II- AT1R FASEB J April 2016 30:1005.6

139. Sharma NM, Mishra PK and Patel KP (2016) Downregulation of Neuronal Nitric Oxide Synthase Within the Paraventricular Nucleus in Insulin Dependent Diabetic Akita Mice. Hypertension. 2016;68: AP153. 2016

140. Sharma NM, Liu X, Llewellyn T, and Patel KP. Exercise Training Augments Neuronal Nitric Oxide Synthase Dimerization in the Paraventricular Nucleus of Rats with Heart Failure FASEB J April 2017 31:687.12

141. Zheng H, Liu X, Knuepfer MM, and Patel KP. Specific Afferent Renal Denervation Improves Reduced nNOS in the Paraventricular Nucleus in Rats with Heart Failure FASEB J April 2017 31:844.4

142. Haibara AS, Sharma NM, Zheng H, Liu X, and Patel KP. Central Angiotensin II Modulation of Hypoxia-Inducible Factor (HIF)-1 Alpha in the PVN: Possible Mechanism for Sympathetic Activation FASEB J April 2017 31:854.4

143. Presentations Invited Symposium Presentations (Local, National and International Meetings)

Midwestern Hypertension Society, Omaha, March 1992 Title of talk: Sympathetic nerve activity in heart failure. Experimental Biology - SYMPOSIUM -Neural control of circulation in heart failure and coronary ischemia, Atlanta, April 1995 Title of talk: Renal sympathetic nerve activity in heart failure; role of the paraventricular nucleus. 3rd International Congress on Heart Failure - Mechanisms and Management: Geneva, Switzerland, May 1995. (Invited) Title of talk: Origins of sympathetic nerve activity in heart failure. 5th International Congress on Heart Failure - Washington, USA, May 1997. (Invited) Title of talk: Role of the paraventricular nucleus in the increased sympathetic nerve activity in heart failure. 6th International Congress on Heart Failure - Geneva, Switzerland, May 1998. (Invited) Title of talk: Neurohumoral activation in heart failure: Role of PVN The Joseph P. Gilmore Distinguished Basic Scientist Award, Honors Symposium,


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University of Nebraska Medical Center (October 1997) Title of talk: Neurohumoral activation in heart failure American Physiological Society sponsored conference about the Paraventricular Nucleus. - San Antonio, USA, December 1998. (Invited) Title of talk: Role of paraventricular nucleus in cardiovascular regulation. 2nd International Congress on Heart Disease - Washington, USA, July 2001. (Invited) Title of talk: Neurohumoral activation in heart failure: NO Brakes 8th International Congress on Heart Failure - Washington, DC, July 2002. (Invited) Title of talk: Neurohumoral activation in heart failure: Role of NMDA receptors Clinical Autonomic Research Symposium - Birmingham, UK December 2002. (Invited) Title of talk: Sympathetic activation during heart failure: NO Brakes. VP Chest Institute, University of Delhi, India. Golden Jubilee, January 2003. (Invited) Title of talk: Exercise training improves centrally mediated regulation of sympathetic outflow in rats with heart failure American Heart association - SYMPOSIUM –Autonomic Regulation of Cardiovascular Function in Heart Failure, Orlando, November 2003 Title of talk: The Central Origins of Sympathetic Outflow in Heart Failure.

Australian Heart Association Research Symposium – Sidney, Australia November 2004. (Invited) Title of talk: Sympathetic activation during heart failure: NO Brakes. American Physiological Soc.-Summer Research Conference: “Neural Mechanisms in Cardiovascular Regulation” – Sidney, Australia November 2007. (Invited) Title of talk: Centrally Mediated Regulation of Sympathetic Outflow in Heart Failure: Improving NO Brakes? Experimental Biology - SYMPOSIUM -“Neuronal Plasticity in Health and Disease”, San Diego, April 2008 Title of talk: Changes in central sites controlling sympathoexcitation during heart failure. 2012 American Physiological Society Conference: Autonomic Regulation of Cardiovascular Function in Health and Disease. Co-Chair for the Organization of the Conference (July 2012) 2012 American Physiological Society Conference: Chair for Session IV: Symptho-excitatory Mechanisms in Cardiovascular Disease. July 2012. 2013. 18th International Congress on Heart Failure - Vancouver, BC, July 2013. (Invited) Title of talk: Blunted responses of renal sympathetic nerve activity to c-Type natriuretic peptide in the PVN of rats with heart failure.

Invited to Chair Sessions (National and International Meetings)

Co-chair of the session on "Cardiovascular adrenergic effects" at the Federation of American Societies for Experimental Biology, Anaheim, CA. April 1985 Co-Chairman, Great Plains Regional Research Review Committee, American Heart Association, St. Louis, MO, March 1992 Chairman, Great Plains Regional Research Review Committee, American Heart Association, St. Louis, MO, March 1993 Chairman of the session on "Neurohumoral Aspects", 3rd International Congress on


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Heart Failure, Geneva, Switzerland, May 1995 Chairman of the session on "Neurohumoral Aspects", 5th International Congress on Heart Failure, Washington, USA, May 1997 Chairman of the session on "Role of forebrain in control of circulation", IUPS Satellite: Central mechanisms of cardiovascular control, Sidney, Australia, August 2001 Chairman of the session on "Neurohumoral Aspects", 8th International Congress on Heart Failure, Washington, USA, July 2002 Chairman of the session on “Nitric oxide signaling in brain in health and disease”, APS Summer Conference: Central mechanisms of cardiovascular control, Sidney, Australia, July, 2007 Co-chair of the session on “Neuronal Plasticity in Health and Disease” at the Federation of American Societies for Experimental Biology, San Diego, CA. April 2008 Chairman for the session on "Sympatho-Excitatory Mechanisms in Cardiovascular Disease", at the FASEB Conference of the American Physiological Society Conference. July 2012

Chairman of the session on "Basic Science"(Invited), 13th International Congress on Heart Failure, Vancouver, USA, July 2013

Invited Seminar Presentations: (National & International Academic Institutions in chronological order)

Department of Internal Medicine - Jan 1986 University of Alberta, Edmonton, Alberta, Canada Title of talk: "Central and peripheral noradrenergic mechanisms in the control of arterial pressure" Department of Physiology & Pharmacology - April 1986 University of South Dakota, Vermillion, SD Title of talk: "Vasopressin and central and peripheral noradrenergic mechanisms." Department of Physiology - June 1988 University of Saskatchewan, Saskatoon, Saskatchewan, Canada Title of talk: "Interaction between vasopressin and autonomic nervous system." Department of Physiology - June 1989 University of Zambia, Lusaka, Zambia, Africa. Title of talk: "Autonomic nervous system and hypertension" Department of Physiology & Biophysics - January 1991 University of Nebraska Medical Center, Omaha, NE Title of talk: "Altered volume reflex in STZ-induced diabetic rats" Department of Anatomy & Physiology - January 1994 Kansas State University, Manhattan, KS Title of talk: "Altered volume reflex in STZ-induced diabetic rats" Department of Pharmacology - February 1994 Creighton University, Omaha, NE Title of talk: "Altered fluid balance regulation in STZ-induced diabetic rats" Department of Physiology - June 1994 University of Western Ontario, London, Ont. Canada Title of talk: "Renal responses to volume expansion in STZ-induced diabetic rats" Department of Pharmacology - October 1994 University of Nebraska Medical Center, Omaha, NE Title of talk: "Altered volume reflex in STZ-induced diabetic rats" Department of Pharmacology - October 1994


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University of Saskatchewan, Saskatoon, Saskatchewan, Canada Title of talk: "Altered neural component of volume reflex in STZ-induced diabetic rats" Department of Biology - January 1995 University of Nebraska at Omaha, Omaha, NE Title of talk: "Altered fluid balance regulation in STZ-induced diabetic rats" Department of Physiology and Pharmacology - September 1995 University of South Dakota, Vermillion, SD Title of talk: "Neural control of altered fluid balance regulation in STZ-induced diabetic rats" Department of Physiology - July 1997 MidWestern University, Glendale Campus, Glendale, Arizona. Title of talk: "Volume regulation in diabetes” Department of Cell Biology & Anatomy - October 1998 University of Nebraska Medical Center, Omaha, NE Title of talk: "Neurohumoral activation during heart failure: NO Brakes” Department of Internal Medicine, Cardiovascular Center - December 1998 University of Iowa, Iowa City, IA. Title of talk: "Neurohumoral activation during heart failure: NO Brakes” Department of Physiology - July 1999 University of Witswaterand, Johannesburg, SA Title of talk: "Neurohumoral activation during heart failure: NO Brakes” Department of Physiology and Internal Medicine - July 1999 College of Medicine, University of Zimbabwe, Harare, Zimbabwe Title of talk: "Neurohumoral activation during heart failure: NO Brakes” Department of Immunology - September 1999 Kansas State University, Manhattan, KS Title of talk: "Neurohumoral activation during heart failure: NO Brakes” Department of Anatomy and Cell Biology - November 1999 University of Alberta, Edmonton, Alberta, Canada Title of talk: "Neurohumoral activation during heart failure: NO Brakes” Department of Physiology - November 1999 University of Calgary, Calgary, Alberta, Canada Title of talk: "Neurohumoral activation during heart failure: NO Brakes” Department of Pharmacology - December 1999 Creighton University, Omaha, NE Title of talk: "Neurohumoral activation during heart failure: NO Brakes” Department of Pathology - October 2000 LSU Health Sciences Center - Shreveport, LA. Title of talk: "Sympathetic activation during heart failure: NO Brakes”

Department of Physiology - March 2001 University of Western Ontario, London, Ont. Canada Title of talk: "Sympathetic activation during heart failure: NO Brakes” Department of Pharmacology and Toxicology - March 2001 Wright State University, Dayton, OH Title of talk: "Neurohumoral activation during heart failure: NO Brakes” Department of Physiology - August 2001 RMIT University, Bandoora, Melbourne, Australia


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Title of talk: "Neurohumoral activation during heart failure: NO Brakes” Department of Pharmacology - March 2002 University of Nebraska Medical Center, Omaha, NE Title of talk: "Neurohumoral activation during heart failure: NO & NMDA interaction within the PVN” Department of Physiology - September 2002 Case Western University, Cleveland, Ohio Title of talk: "Sympathetic activation during heart failure: NO Brakes” Department of Physiology - October 2002 University of San Antonio Medical Center, San Antonio, Texas Title of talk: "Neurohumoral activation during heart failure: NO Brakes” Department of Medicine - December 2002 University of London, London, UK Title of talk: "Sympathetic activation during heart failure: NO Brakes” Department of Physiology - December 2002 University of Bristol, Bristol, UK Title of talk: "Neurohumoral activation during heart failure: NO & NMDA interaction within the PVN” Department of Physiology - December 2002 Oxford University, Oxford, UK Title of talk: "Sympathetic activation during heart failure: NO Brakes” Department of Physiology - December 2002 University of Birmingham, Birmingham, UK Title of talk: "Sympathetic activation during heart failure: NO Brakes” Department of Physiology - January 2003 University of New Delhi, New Delhi, India Title of talk: "Neurohumoral activation during heart failure: NO Brakes” Department of Physiology - October 2004 Louisiana State University - Vet. School Baton Rouge, LA, USA Title of talk: "Sympathetic activation during heart failure: NMDA mechanisms” Department of Pharmacology - October 2004 Louisiana State University- Medical School, New Orleans, LA, USA Title of talk: "Sympathetic activation during heart failure: NO/NMDA mechanisms” Department of Physiology - November 2004 University of Sydney, Sydney, Australia Title of talk: "Sympathetic activation during heart failure: PVN mechanisms” Department of Pharmacology - October 2005 Temple University - Philadelphia, PA USA Title of talk: "Sympathetic activation during heart failure” Department of Pharmacology - September 2005 University of South Dakota – Vermillion, SD, USA Title of talk: "Sympathetic activation during heart failure: Effect of exercise training ”


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Department of Pharmacology - July 2006 St. Louis University - Medical School, St Louis, MO USA. Title of talk: "Sympathetic activation during heart failure: NO Brakes” Department of Physiology – February 2008 University of Sao Paulo, Sao Paulo, Brazil Title of talk: "Sympathetic activation during heart failure: NO Brakes” Department of Physiology – February 2008 Universidade Federal de Minas Gerais, Belo Horizonte, Brazil Title of talk: "Sympathetic activation during heart failure: NO Brakes” Department of Physiology – February 2008 Universidade de Sao Paulo, Ribeirao Preto, Brazil Title of talk: "Sympathetic activation during heart failure: NO Brakes” Department of Physiology – March 2008 Universidade Federal Fluminense, Niteroi, Rio de Janeiro, Brazil Title of talk: "Sympathetic activation during heart failure: NO Brakes” Department of Physiology – October 2008 University of Georgia – Agusta, GA. USA. Title of talk: "Sympathetic activation during heart failure: Effect of exercise training” Cardiovascular Center, Department of Physiology – June 2010 University of Iowa – Iowa City, IA. USA. Title of talk: "Sympathetic activation during heart failure: Effect of exercise training” Department of Pharmacology & Physiology – February 2011 Michigan State University – East Lansing, MI. USA. Title of talk: "Sympathetic activation during heart failure: Effect of exercise training” Invited speaker at the University Federal de Minas Gerais, Belo Horizonte, Brazil – 5-7 September 2011. Gave a talk and spent time with graduate student teaching and discussed possible collaborations. Invited speaker at Workshop in Autonomic Regulation at the University Federal de Minas Gerais, Oro Preto in Brazil – 8 September 2011 University of Sao Paulo, Riberao Preto, Brazil, (September 2011) – Gave a talk and spent time with graduate student teaching and discussed possible collaborations. Department of Physiology - March 2012 Louisiana State University - Vet. School Baton Rouge, LA, USA Title of talk: "Sympathetic activation during heart failure” Institute for Integrative Physiology & Center for Systems Biology of O2 sensing – September 2012 University of Chicago – Chicago, IL. USA Title of talk: "Sympathetic activation during heart failure: Effect of exercise training

Department of Nephrology – March 2014 University of California at San Diego – San Diego, CA. USA. Title of talk: "Sympathetic activation during heart failure: Improving NO Brakes”


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Invited speaker at a Symposium in São Paulo (Heart Institute) on next August 11-12 2014, whose title was: Autonomic neural regulation of the immune system: implications for hypertension and cardiovascular diseases. Invited speaker at Symposium at the Brazilian Society of Hypertension and Inter-American Society of Hypertension meeting in Salvador (Bahia) on August 14-16, 2015

Department of Anatomy & Physiology – October 2015 Louisiana State University Health Sciences Center – Shreveport, LA. USA. Title of talk: "Centrally Mediated Enhanced Sympathetic Outflow in Heart Failure: Effect of Renal Denervation”

Department of Anatomy & Physiology – October 2015 Louisiana State University Health Sciences Center – Shreveport, LA. USA. Title of talk: "Centrally Mediated Enhanced Sympathetic Outflow in Heart Failure: Effect of Renal Denervation”

Department of Biology – April 2016 Union College, Lincoln, NE. USA. Title of talk: "Centrally Mediated Enhanced Sympathetic Outflow in Heart Failure: Effect Exercise training”

Department of Biomedical Sciences - March 2017 University of South Dakota – Vermillion, SD, USA

Title of talk: " Centrally Mediated Enhanced Sympathetic Outflow in Heart Failure “Improving “NO” BRAKES”


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TEACHING ACTIVITIES University of Western Ontario Laboratory Instructor - 1978-1981 Physiology 306 (Special laboratory section) 1980-1983 Medical Physiology Tutorial Leader - 1982-1983 Allied Health Physiology Mentor - 1983 Honors Physiology thesis project Organized and ran a Journal Club for “Cardio-renal” Physiology University of South Dakota Participation in Team-taught Courses - 1987-1991 Medical Physiology Cardiovascular Physiology (24 lectures) Introductory Survey of the Circulation Hemodynamics - Study of Blood Flow Electrical Properties of the Heart Cardiac Cycle Mechanical Properties of the Heart Control of Vascular Resistance Microcirculation Veins, Venous Return and Cardiac Output Cardiovascular Reflexes Special Vascular beds - Coronary and Cerebral Integrated Response of the Circulation Hypertension Autonomic Nervous System (2 lectures) Nerve and Action Potential (4 lectures) Laboratory Supervision (16-20 hours annually) 1987-1991 Medical Physiology Small group sessions (2 hours weekly) 1990-1991 Co-course Director - Medical Physiology 1987-1991 Medical Pharmacology Laboratory Supervision (40 hours annually) 1987-1991 Physiology for the Nurses (Fall and Summers) Cardiovascular Section (9 lectures)


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Complete Course Taught by Dr. Patel - 1989-1990 Cardiovascular Physiology (20 hours; lecture/tutorial/journal club format; 3 credits) 1987, 1988 Seminar course Participation in Journal Club -1987-1991 Supervision of Graduate/Medical Student Research - Medical students - Romano Adajar - summer 1988 Ray Topple - summer 1989 Cindy Duimstra - summer 1989 Jeff Heier - summer 1990 Mike Heins - summers 1990 & 1991 Manoj Patel - summer 1991 Graduate students - Romano Adajar - research rotation - 1987 Kora Chen - research rotation - 1988 Graham Smith - research rotation - 1989 Ping Zhang - research rotation -1988,1989 Adriana S. Ribeiro - research rotation - 1990 Lulu Zhang - research rotation -1990 Mentor for graduate students: Ping Zhang -1987-1991- Supervisor-

Advisor for graduate students: Thesis Committee Ping Zhang -1987-1991- Supervisor- Graham Smith - Thesis committee Supervision of Post-doctoral Trainees - Georges Awah - 1988 Ping Zhang - 1991-92

University of North Dakota I was invited to present “Renal Physiology” lectures to Medical students at the Department of Physiology, UND - Participation in Team-taught Courses - 1989-1990 Medical Physiology - Renal Physiology section (12 lectures)


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University of Nebraska Medical Center Participation in Team-taught Courses - 1994- 2003 Medical Physiology (Renal Physiology) 1910- 2011 Medical Physiology (Renal Physiology) 1913- 2015 Medical Physiology (Renal Physiology) Renal Physiology section of Core 4 (12 lectures & 2-4 hours question/answer) Body Fluid Compartments Anatomy of the Kidney Circulation Glomerular Filtration Tubular Reabsorption and Secretion Measurement of Renal Function Renal regulation of Sodium, Chloride and Water Regulation of extracellular Fluid Volume Regulation of extracellular Fluid Osmolality Potassium Homeostasis Hydrogen (acid-base balance) 1999- 2006 Medical Physiology- Renal problem set - (2 sessions 2-4 h) 1994- 2015 Adrenal Medulla section of Core 4 (1 lectures) 1991,1992, 2004,2005, 2006, 2007 Physiology for Pharmacy, PA, PT Renal Physiology section (10 lectures- topics listed above)

Complete Course Taught by Dr. Patel - 1993-1996 Physiology Seminar course Courses organized by Dr. Kaushik P. Patel 1991 Graduate Renal Physiology (Historical and current concepts in renal physiology) (20 hours; lecture/tutorial/journal club format; 2 credits) 1996 Graduate Renal Physiology (Neural /Humoral regulation of salt & water balance) (20 hours; lecture/tutorial/journal club format; 2 credits) Courses Organized by Dr. Kaushik P. Patel 1997 Graduate Cardiovascular Physiology (Neural/Humoral regulation of circulation) (20 hours; lecture/tutorial/journal club format; 2 credits) 1999 Graduate Cardiovascular Physiology (Reflex regulation of circulation) (20 hours; lecture/tutorial/journal club format; 2 credits) 2000 Graduate Renal Physiology (Salt & water balance) (20 hours; lecture/tutorial/journal club format; 2 credits)


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Graduate Courses: 2007 Graduate Cardiovascular Physiology course (Fall) 2008 Graduate Renal Physiology course (Winter) 2009 Graduate Cardiovascular Physiology course (Fall) 2010 Graduate Renal Physiology course (Winter) 2011 Graduate Cardiovascular Physiology course (Fall) 2012 Graduate Renal Physiology course (Winter) 2013 Graduate Pulmonary & Cardiovascular Physiology course (Fall) 2014 Graduate “Renal Physiology” course (Winter) – three sessions, 2 hours each 2015 Graduate “Ions Channel” course (Winter) 2015 Graduate Cardiovascular Physiology course (Winter) 2016 Graduate Renal Physiology course (Winter) Published audiovisual educational material - Prepared a “question-answer” work handout for three sections of the Medical Physiology course. This handout is distributed to the students each year that I have taught these sections and I have had a very positive response from the students regarding the use of this handout for studying short-term as well as for the long-term (i.e. Board exams). Cardiovascular Physiology; Renal Physiology; Autonomic Nervous System Supervision of Graduate/Medical Student Research - Medical students - John Goering (Pre-Med) - summers 1992 John Goering (M1) - summers 1993 Patrick Fuller – (Pre-Med) -summers 1993 Andy Reynold (Pre-Med) -summer 1995 Andy Reynold (M1) -summer 1996 Andy Reynold (M3) -1999 - Masters Thesis (Supervisor) Michael Christman (M1) - summer 2000 Neil A. Aranha (M1) - summer 2001 Benjamin Acker (M1)- summer 2002 Brandon Rabiller (M1)– summer 2004 Nathan Murdoch(M1) - summer 2005 Nathan Murdoch (M3) - Fall 2007 – Honors MD Thesis Rishi Batra (M1)– summer 2010 Justin S Ritonya (M1) – summer 2010 Craig Cunningham – (MD- PhD candidate (summer 2011) Zake Wages – (MD- PhD candidate (summer 2013) Jake Fleecs (M1)– summer 2015 Mitchell Chlopek (M1) – summer 2015 Graduate students - Kay Rhynchon - research rotation - 1992-93 Sudeep Nair - research rotation - 1992-93 Corrie Karimji - research project - 1996


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Mentor for graduate students: Kun Zhang -1993- 1998 (Supervisor) Sean Didion - 1993-98 Xu Zhi - 1993-97 Vikram Arora - 1993 Bin Tang - 1996-97 Yu Wang - 2000-2004 (Co- Supervisor) Allison Keibler – 2004-2010 (Supervisor) Laura Leite – 2008-2009 – Brazilian PhD student Juliana Guimaraes - 2009 – Brazilian PhD student Tamra Llewellyn 2010 – 2013 (Supervisor) Gisele Vas 2013- 2014– Brazilian PhD student Advisor for graduate students: Thesis Committees:

Kun Zhang - 1993-1997, Ph.D. Thesis committee (Supervisor) Greg Fitz - 1994-1998, Ph.D. Thesis committee - (Kansas State) Sean Didion - 1993-1998, Ph.D. Thesis committee Xu Zhi - 1993-1997, Ph.D. Thesis committee Jun Li -1995-1999, Ph.D. Thesis committee Rong Ma -1995-1999, Ph.D. Thesis committee Yi-Ming Zhang -1999 -, Ph.D. Thesis committee Yu Wang -2000 -2004, Ph.D. Thesis committee (Co-Supervisor) Surya P. Ayalasomayajula -2000 -, Ph.D. Thesis committee Nermien E. Waly -2001 -, Ph.D. Thesis committee (Creighton University) Qin Fang -2001 - 2005, Ph.D. Thesis committee Razia Aziz-Seible -2006 -Ph.D. Comprehensive Exam committee (Department of Biochemistry and Molecular Biology) Sarah C. Clayton -2006 -2011, Ph.D. Thesis committee Ram Chettiar -2006-2010, MSc. Thesis committee Allison Keibler - 2004-2010, Ph.D. Thesis committee (Supervisor) Laura Leite – 2008 – Sandwich program from Brazil Juliana Guimaraes 2009- Sandwich Program from Brazil Tamra Llewellyn 2010 – 2013, Ph.D. Thesis Committee (Supervisor) Urmi Basu 2011 – 2015, Ph.D. Thesis Committee (Physiology) Lue Yang 2011 – 2015, Ph.D. Thesis Committee (Pharmacology) Ha Duy 2011 – Present, MD-Ph.D. Thesis Committee (Physiology) Suresh Anand -2012 - Ph.D. Comp. Exam Commit. (Biochemistry) Michael Price 2014 – Present, MD-Ph.D. Thesis Committee (Physiology) Gisele Vas 2013-2014 Sandwich Program from Brazil Shamma Rahman 2014-Present Ph.D. Thesis Committee (Physiology)


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Supervision of Post-doctoral Trainees - Georges Awah - 1988 – Professor of Pharmacology- Nigeria Ping L.Zhang - 1992 Director Renal Pathology, William Beaumont Hosp., Royal Oak, MI. Kun. Zhang – 1998 – Director of Neurophysiology Laboratories (UTSA, Texas) Yi fan Li - 1999-2005 – Associate Professor, University of South Dakota Hong Fung - 2000-2002 – Surgery Technician Hong Zheng - 2000-2007 – Assistant Professor, UNMC Xue-Fei Liu - 2001-2005 – Research Technologist, UNMC Neeru Sharma - 2009-2014 – Instructor, UNMC Bo Xu - 2010 – 2013 – Post-doctoral fellow Adam Case 2014- 2016 – Post-doctoral Fellow/Research Associate Kenichi Katsurada 2017- present – Post-doctoral Fellow/Research Associate Mentor for Junior Faculty - Hong Zheng – Assistant Professor - 2007 - present Matt Zimmerman – Associate Professor - 2007 - present Paras Mishra – Assistant Professor - 2013 - present Neeru Sharma - 2015-present – Assistant Professor, UNMC Andrea Haibara 2015-2016 – Associate Prefessor, Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

One year visiting scientist Program from Brazil Funding of Students/Postdocs in Dr. Patel’s Laboratory: Ping L. Zhang, Pre-doctoral Fellowship, American Heart Association, 1988-89 Total direct amount of award: $18,000 Ping L. Zhang, Pre-doctoral Fellowship, American Heart Association, 1989-90 Total direct amount of award: $18,000 Ping L. Zhang, Post-doctoral Fellowship, American Heart Association, 1992-3 Total direct amount of award: $38,000 John Goering, Medical Student Fellowship, UNMC, 1994 Total direct amount of award: $2,000 Corrie Cahow, Summer Student Fellow, American Heart Association, 1994 Total direct amount of award: $1,500 Andy Reynolds, Medical Student Fellowship, (Best application), UNMC, 1996 Total direct amount of award: $2,500 Kimberly Buske, Summer Student Fellowship, American Heart Association, 1997 Total direct amount of award: $1,500 Kimberly Buske, Summer Student Fellowship (MD-Ph.D.), Deans Office 2000 Total direct amount of award: $3,000 Neil A. Aranha, Medical Student Fellowship (MD), Deans Office 2001 Total direct amount of award: $3,000 Yi-Fan Li, Post-doctoral Fellowship, American Heart Association, 2001-03 Total direct amount of award: $75,000 Hong Zheng, Post-doctoral Fellowship, American Heart Association, 2002-04 Total direct amount of award: $75,000


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Benjamin Ackers, Medical Student Fellowship, UNMC, 2002 Total direct amount of award: $2,500 Nate Murdock, Medical Student Fellowship, UNMC, 2005 Total direct amount of award: $3,500 Kate Barry, BRIN fellowship, UNMC, 2005 Total direct amount of award: $3,500 Jenna Coalson, American Physiological Society Summer Fellowship, 2005 Total direct amount of award: $3,500 Alison Keibler, Pre-doctoral Fellowship, American Heart Association, 2005-07 Total direct amount of award: $50,000 Jake Johnson, BRIN fellowship, UNMC, 2005 Total direct amount of award: $3,500 Alison Keibler, Pre-doctoral Fellowship, UNMC, 2007-08 Total direct amount of award: $23,000 Justin S Ritonya, Medical Student Fellowship, UNMC, 2010 Total direct amount of award: $3,500 Craig Cunningham, Potential MD-PhD Student Fellowship, UNMC, 2011 Total direct amount of award: $3,500 Tamra Llewellyn, Pre-doctoral Fellowship, UNMC, 2011-14 Total direct amount of award: $75,000 Zack Wages, Potential MD-PhD Student Fellowship, UNMC, 2013 Total direct amount of award: $3,500 Jake Fleecs , Medical Student Fellowship, UNMC, 2015 Total direct amount of award: $3,500 Mitchell Chlopek , Medical Student Fellowship, UNMC, 2015 Total direct amount of award: $3,500 Mentor on Faculty grants: Yi-Fan Li, Scientist Development Grant, American Heart Association, 2004-08 Total direct amount of award: $240,000 Hong Zheng, Scientist Development Grant, American Heart Association, 2007-11 Total direct amount of award: $236,364 Neeru Sharma, Scientist Development Grant, American Heart Association, 2014-18 Total direct amount of award: $300,000 Funding of “School Teacher” in Dr. Patel’s Laboratory: Cindy Orso, “Summer Teacher” Fellowship, American Physiological Society 1996 Total direct amount of award: $5,000

kaushik p. p - university of nebraska medical center · 2020-04-03 · 2017 patel, kaushik p. 2...

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