keith sanderson - formulation · particulate analysis q surface area, morphology and surface...
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Keith Sanderson Sanderson Technology Ltd
Royal Society of Chemistry Burlington House, London
10th November 2017
www.sandersontech.com [email protected]
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Microtrac Image Analysis
Particle Size and Shape PartAn SI
Mageleka Proton NMR measurements of dispersions
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Size Range 5µm to 1500µm
Size Range 4µm to 3500µm Size Range 280µm to 127,000µm On Line
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Vibratory Feeder
Flow of Particles
Rotation of 1
Particle
Camera 3D Multiple images of SAME Particle. 3D - Tracking is the key. Location is tracked and images obtained for different orientations of particle giving 3D information 2D - No tracking – Only 1 photo of particle
Microtrac Innovation: Patented 3D measurement technique
1 1
1 2
1 3
1 4
1 5
1 6
1 7
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3D Image analysis
Particles analysed with 3D Image Technology Falling direction
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Measurement Principle The software counts the pixels covered by the particle
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Filter Function
Glass Beads
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Shape Factors Good and Bad particle sorted and counted by user defined shapes factors
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Results Analysis
Every Particle Measured And Recorded Available for Further Analysis at a Future Date
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All three dimensions measured, including Thickness
More accurate volume distributions
Much more accurate size measurements
More accurate shape (sphericity) measurements
Enables accurate reporting of more than 36 morphological parameters
The Advantages of 3D Image Analysis (patented by Microtrac)
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Private Company formed in 2014 and self funded Formed by 5 seasoned entrepreneurs with expertise
in electronics, software, nmr, finance and application
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• New analytical instrument for analysis of complex mixtures • Measures macroscopic physical characteristics using multi-nuclear nmr • Separate probe allows use in distant location • XRS focused on dispersed particle surface area
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Relaxation q particulate analysis q surface area, morphology and surface chemistry
q sedimentation and aggregation q molecular analysis q polymer complexation and surfactant adsorption
q competitive adsorption/desorption
q Diffusivity either continuous or dispersed phase q total aggregate size (complexation) q restrictions to motion (restricted diffusion)
q emulsion drop size
T1 AND T2 Pulse Sequences
Techniques
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N
N
Apply a pulse Nuclei will then relax Unbound relax slower
N Measure relaxation Calculate surface area
Bound and unbound water in solution
How does it Work?
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Application: Wetted Surface Area
Almost any particle of any size or shape
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Application: Sedimentation Relaxation time increases as settling particles pass out of the measuring zone
Sedimentation of a 10wt% aqueous suspension of 200nm Barium Titanate
Time mode allows monitoring of suspension stability
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NMR relaxation provides an easy in-situ measurement of adsorption onto a surface
Application: In situ Surfactant Adsorption
0.0 1.0 2.0 0.0
3.0 4.0
optimum coverage
Surfactant % w/w
0.4
0.8
Particles: 50nm Silica Surfactant: SDES
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[SDS] (mM)
0 10 20 30 40 50R
2sp
2.0
2.5
3.0
3.5
4.0
4.5
Bare silicaSilica + 1mg/m2 PVP
stable
unstable
PVP added per unit area of silica / mg m-2
0 2 4 6 8 10
R2s
p
0.0
0.2
0.4
0.6
0.8
1.0
Adsorption of PVP onto bare silica Desorption of PVP upon addition of SDS
optimum coverage
Application: Competitive Adsorption of a Surfactant and Polymer onto 15nm Silica
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QC application to control batch to batch reproducibility
• Pharmaceutical • Inks • Cosmetics • Sunscreens • Graphene/Graphite • Oil and Gas • Polymer application
APPLICATIONS
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Sanderson Technology Available Techniques
Wetted surface area measurements – Bench Top NMR
Particle Size Distribution - Acoustic Attenuation Spectroscopy
Laser Diffraction, Dynamic Light Scattierng
Single Particle Optical Sizing (SPOS)
Zeta Potential – Electrokinetic Sonic Amplitude
Image Analysis Materials Characterisation, Formulation Consultancy
www.sandersontech.com [email protected]