Lung adenocarcinoma genomes of never smokers exhibit a greater extent of genomic instability than those of smokers

Kelsie Thu1, Daiana Becker1, Raj Chari2, Wei Zhang3, Calum MacAulay1, Adi Gazdar3, Stephen Lam1, Wan Lam1

1BC Cancer Research Centre, Vancouver, Canada, 2Harvard Medical School, Boston, USA,3University of Texas Southwestern, Dallas, USA

World Conference on Lung Cancer, Amsterdam 2011July 4th, 2011

Lung Cancer in Never Smokers (NS)

7th leading cause of cancer death in world

Sun S. et al. Nat Rev Cancer 7(10):778-90 (2007)

Chr 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19202122 X

Freq

uenc

yFr

eque

ncy

0

0.5

0.5

Smokers

Chr 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19202122 X

NeverSmokers

Gai

nLo

ssG

ain

Loss

0

0.5

0.5

Frequency of Alterations

Copy number profiles generated from Affymetrix SNP 6 arrays

NS Lung Tumors Exhibit Greater Genomic Instability

MSKCC dbGaP

p = 0.028

BCCRC

p = 0.004 p = 0.128

Differentially Altered Regions

IL12B, RNF145, UBLCP1MAT2B

C7orf10, INHBAABCA13

A2BP1, ABAT, C16orf68, CARHSP1, PMM2, TMEM186

6 minimal common regions of copy number gain specific to NS 5q 7p 16p